Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma
Povezanost histopatoloških karakteristika karcinoma usne sa progresijom bolesti
Апстракт
The most common malignancy of the lip is squamous cell carcinoma (SCC). In our population, according to epidemiological data, almost a half of all (45%) SCC of oral mucous tissue spreads over the lower and upper lip. The aim of this study was to estimate prognostic importance of histopathologic characteristics - histologic grade, nuclear grade and tumor size in relation to the appearance of lymph node metastases and relapse in SCC of the lip. Methods. In the retrospective- prospective study 70 cases of lower and upper lip SCC were analyzed. They were diagnosed from 2002 to 2006 in the Clinic of Maxillofacial Surgery, Clinical Center of Montenegro. The data about localization of the carcinomas, histopathologic characteristics and lymph node status were taken from medical files of the patients. The patients were followed up in a 3-year period and the disease relapse or/and metastatic disease appearance were registereds. Results. There was statistically significant difference in tumor siz...e among the patients with and without disease relapse (p = 0.027). Logistic regression analysis showed that the tumor size is a statistically significant factor (R = 0.186; p = 0.011) for the appearance of regional lymph node metastases. Relative risk [exp (B)] for the appearance of regional lymph node metastases in relation to tumor size was 2.807. Conclusion. Histologic and nuclear grade of lip SCC are not prognostic factors for the appearance of the disease relapse and regional lymph node metastases. Tumor size is a predictive factor of the relapse appearance, as well as for lymph node metastases appearance. In clinical practice, tumor size is a factor that classifies patients with lip SCC into the groups of higher and smaller risk of relapse appearance and for lymph node metastases appearance. Our results suggest that, risk for lymph node metastases appearance increases 2.8 times with increasing of the tumor size over 2 cm in diameter.
Uvod/Cilj. Planocelularni karcinom (PCC) je najčešće maligno oboljenje usne. Prema epidemiološkim podacima, u našoj populaciji skoro polovina (45%) PCC sluzokože usne duplje zahvata i donju i gornju usnu. Cilj ovog rada bio je utvrđivanje prognostičkog značaja histopatoloških karakteristika PCC usne: histološkog gradusa, nuklearnog gradusa i veličine tumora za pojavu recidiva bolesti i metastaza u regionalnim limfnim čvorovima. Metode. U retrospektivno-prospektivnoj studiji analizirano je 70 bolesnika sa PCC donje i gornje usne, dijagnostikovanim u periodu od 2002. do 2006. godine u Klinici za maksilofacijalnu hirurgiju Kliničkog centra Crne Gore. Podaci o lokalizaciji neoplazmi, životnom dobu i polu bolesnika, kao i o histopatološkim karakteristikama neoplazmi uzeti su iz uputnika za histopatološki pregled. Tokom tri godine, na redovnim postoperativnim kliničkim kontrolama, registrovana je eventualna pojava recidiva i/ili metastatske bolesti. Rezultati. Veličina tumora se statistički ...značajno razlikovala između ispitanika sa i bez recidiva bolesti (p = 0,027). Logističkom regresionom analizom utvrđeno je da je veličina tumora bila statistički značajan faktor (p = 0,011, R = 0,186) za pojavu metastaza u regionalnim limfnim čvorovima. Relativni rizik [exp (B)] od pojave metastaze u regionalnim limfnim čvorovima u odnosu na veličinu tumora iznosio je 2,807. Zaključak. Histološki i nuklearni gradusi tumora nisu prognostički faktori pojave recidiva i metastatske bolesti PCC usne. Veličina tumora predstavlja prognostički faktor za pojavu recidiva i regionalnih metastaza PCC usne, tj. faktor koji omogućava podelu bolesnika sa karcinomom usne u grupu sa većim, odnosno manjim rizikom od pojave recidiva i/ili metastatske bolesti. Prema našim rezultatima, sa povećanjem veličine PCC usne iznad 2 cm rizik od pojave regionalnih metastaza povećava se 2,8 puta.
Кључне речи:
lip neoplasms / neoplasms squamous cell / neoplasm staging / disease progression / neoplasm metastasis / risk factors / histological techniques / usna, neoplazme / karcinom skvamoznih ćelija / neoplazme, određivanje stadijuma / bolest, progresija / neoplazme, metastaze / faktori rizika / histološke tehnikeИзвор:
Vojnosanitetski pregled, 2010, 67, 1, 19-24Издавач:
- Vojnomedicinska akademija - Institut za naučne informacije, Beograd
DOI: 10.2298/VSP1001019G
ISSN: 0042-8450
WoS: 000274426200004
Scopus: 2-s2.0-75749152083
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Golubović, Mileta AU - Ašanin, Bogdan AU - Jelovac, Drago AU - Petrović, Milan AU - Antunović, Marija PY - 2010 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1536 AB - The most common malignancy of the lip is squamous cell carcinoma (SCC). In our population, according to epidemiological data, almost a half of all (45%) SCC of oral mucous tissue spreads over the lower and upper lip. The aim of this study was to estimate prognostic importance of histopathologic characteristics - histologic grade, nuclear grade and tumor size in relation to the appearance of lymph node metastases and relapse in SCC of the lip. Methods. In the retrospective- prospective study 70 cases of lower and upper lip SCC were analyzed. They were diagnosed from 2002 to 2006 in the Clinic of Maxillofacial Surgery, Clinical Center of Montenegro. The data about localization of the carcinomas, histopathologic characteristics and lymph node status were taken from medical files of the patients. The patients were followed up in a 3-year period and the disease relapse or/and metastatic disease appearance were registereds. Results. There was statistically significant difference in tumor size among the patients with and without disease relapse (p = 0.027). Logistic regression analysis showed that the tumor size is a statistically significant factor (R = 0.186; p = 0.011) for the appearance of regional lymph node metastases. Relative risk [exp (B)] for the appearance of regional lymph node metastases in relation to tumor size was 2.807. Conclusion. Histologic and nuclear grade of lip SCC are not prognostic factors for the appearance of the disease relapse and regional lymph node metastases. Tumor size is a predictive factor of the relapse appearance, as well as for lymph node metastases appearance. In clinical practice, tumor size is a factor that classifies patients with lip SCC into the groups of higher and smaller risk of relapse appearance and for lymph node metastases appearance. Our results suggest that, risk for lymph node metastases appearance increases 2.8 times with increasing of the tumor size over 2 cm in diameter. AB - Uvod/Cilj. Planocelularni karcinom (PCC) je najčešće maligno oboljenje usne. Prema epidemiološkim podacima, u našoj populaciji skoro polovina (45%) PCC sluzokože usne duplje zahvata i donju i gornju usnu. Cilj ovog rada bio je utvrđivanje prognostičkog značaja histopatoloških karakteristika PCC usne: histološkog gradusa, nuklearnog gradusa i veličine tumora za pojavu recidiva bolesti i metastaza u regionalnim limfnim čvorovima. Metode. U retrospektivno-prospektivnoj studiji analizirano je 70 bolesnika sa PCC donje i gornje usne, dijagnostikovanim u periodu od 2002. do 2006. godine u Klinici za maksilofacijalnu hirurgiju Kliničkog centra Crne Gore. Podaci o lokalizaciji neoplazmi, životnom dobu i polu bolesnika, kao i o histopatološkim karakteristikama neoplazmi uzeti su iz uputnika za histopatološki pregled. Tokom tri godine, na redovnim postoperativnim kliničkim kontrolama, registrovana je eventualna pojava recidiva i/ili metastatske bolesti. Rezultati. Veličina tumora se statistički značajno razlikovala između ispitanika sa i bez recidiva bolesti (p = 0,027). Logističkom regresionom analizom utvrđeno je da je veličina tumora bila statistički značajan faktor (p = 0,011, R = 0,186) za pojavu metastaza u regionalnim limfnim čvorovima. Relativni rizik [exp (B)] od pojave metastaze u regionalnim limfnim čvorovima u odnosu na veličinu tumora iznosio je 2,807. Zaključak. Histološki i nuklearni gradusi tumora nisu prognostički faktori pojave recidiva i metastatske bolesti PCC usne. Veličina tumora predstavlja prognostički faktor za pojavu recidiva i regionalnih metastaza PCC usne, tj. faktor koji omogućava podelu bolesnika sa karcinomom usne u grupu sa većim, odnosno manjim rizikom od pojave recidiva i/ili metastatske bolesti. Prema našim rezultatima, sa povećanjem veličine PCC usne iznad 2 cm rizik od pojave regionalnih metastaza povećava se 2,8 puta. PB - Vojnomedicinska akademija - Institut za naučne informacije, Beograd T2 - Vojnosanitetski pregled T1 - Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma T1 - Povezanost histopatoloških karakteristika karcinoma usne sa progresijom bolesti VL - 67 IS - 1 SP - 19 EP - 24 DO - 10.2298/VSP1001019G ER -
@article{ author = "Golubović, Mileta and Ašanin, Bogdan and Jelovac, Drago and Petrović, Milan and Antunović, Marija", year = "2010", abstract = "The most common malignancy of the lip is squamous cell carcinoma (SCC). In our population, according to epidemiological data, almost a half of all (45%) SCC of oral mucous tissue spreads over the lower and upper lip. The aim of this study was to estimate prognostic importance of histopathologic characteristics - histologic grade, nuclear grade and tumor size in relation to the appearance of lymph node metastases and relapse in SCC of the lip. Methods. In the retrospective- prospective study 70 cases of lower and upper lip SCC were analyzed. They were diagnosed from 2002 to 2006 in the Clinic of Maxillofacial Surgery, Clinical Center of Montenegro. The data about localization of the carcinomas, histopathologic characteristics and lymph node status were taken from medical files of the patients. The patients were followed up in a 3-year period and the disease relapse or/and metastatic disease appearance were registereds. Results. There was statistically significant difference in tumor size among the patients with and without disease relapse (p = 0.027). Logistic regression analysis showed that the tumor size is a statistically significant factor (R = 0.186; p = 0.011) for the appearance of regional lymph node metastases. Relative risk [exp (B)] for the appearance of regional lymph node metastases in relation to tumor size was 2.807. Conclusion. Histologic and nuclear grade of lip SCC are not prognostic factors for the appearance of the disease relapse and regional lymph node metastases. Tumor size is a predictive factor of the relapse appearance, as well as for lymph node metastases appearance. In clinical practice, tumor size is a factor that classifies patients with lip SCC into the groups of higher and smaller risk of relapse appearance and for lymph node metastases appearance. Our results suggest that, risk for lymph node metastases appearance increases 2.8 times with increasing of the tumor size over 2 cm in diameter., Uvod/Cilj. Planocelularni karcinom (PCC) je najčešće maligno oboljenje usne. Prema epidemiološkim podacima, u našoj populaciji skoro polovina (45%) PCC sluzokože usne duplje zahvata i donju i gornju usnu. Cilj ovog rada bio je utvrđivanje prognostičkog značaja histopatoloških karakteristika PCC usne: histološkog gradusa, nuklearnog gradusa i veličine tumora za pojavu recidiva bolesti i metastaza u regionalnim limfnim čvorovima. Metode. U retrospektivno-prospektivnoj studiji analizirano je 70 bolesnika sa PCC donje i gornje usne, dijagnostikovanim u periodu od 2002. do 2006. godine u Klinici za maksilofacijalnu hirurgiju Kliničkog centra Crne Gore. Podaci o lokalizaciji neoplazmi, životnom dobu i polu bolesnika, kao i o histopatološkim karakteristikama neoplazmi uzeti su iz uputnika za histopatološki pregled. Tokom tri godine, na redovnim postoperativnim kliničkim kontrolama, registrovana je eventualna pojava recidiva i/ili metastatske bolesti. Rezultati. Veličina tumora se statistički značajno razlikovala između ispitanika sa i bez recidiva bolesti (p = 0,027). Logističkom regresionom analizom utvrđeno je da je veličina tumora bila statistički značajan faktor (p = 0,011, R = 0,186) za pojavu metastaza u regionalnim limfnim čvorovima. Relativni rizik [exp (B)] od pojave metastaze u regionalnim limfnim čvorovima u odnosu na veličinu tumora iznosio je 2,807. Zaključak. Histološki i nuklearni gradusi tumora nisu prognostički faktori pojave recidiva i metastatske bolesti PCC usne. Veličina tumora predstavlja prognostički faktor za pojavu recidiva i regionalnih metastaza PCC usne, tj. faktor koji omogućava podelu bolesnika sa karcinomom usne u grupu sa većim, odnosno manjim rizikom od pojave recidiva i/ili metastatske bolesti. Prema našim rezultatima, sa povećanjem veličine PCC usne iznad 2 cm rizik od pojave regionalnih metastaza povećava se 2,8 puta.", publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd", journal = "Vojnosanitetski pregled", title = "Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma, Povezanost histopatoloških karakteristika karcinoma usne sa progresijom bolesti", volume = "67", number = "1", pages = "19-24", doi = "10.2298/VSP1001019G" }
Golubović, M., Ašanin, B., Jelovac, D., Petrović, M.,& Antunović, M.. (2010). Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma. in Vojnosanitetski pregled Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 67(1), 19-24. https://doi.org/10.2298/VSP1001019G
Golubović M, Ašanin B, Jelovac D, Petrović M, Antunović M. Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma. in Vojnosanitetski pregled. 2010;67(1):19-24. doi:10.2298/VSP1001019G .
Golubović, Mileta, Ašanin, Bogdan, Jelovac, Drago, Petrović, Milan, Antunović, Marija, "Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma" in Vojnosanitetski pregled, 67, no. 1 (2010):19-24, https://doi.org/10.2298/VSP1001019G . .