Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus
Само за регистроване кориснике
2013
Аутори
Daković, DraganaČolić, Miodrag
Čakić, Saša
Mileusnić, Ivan
Hajduković, Zoran
Stamatović, Novak
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objective: The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type I diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established Methods: Twenty children and adolescents with Type I DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. Results: The Salivary IL-8 level was statistically significantly (p lt 0.005) elevated in subjects with Type 1 DM (474.47 +/- 716.76) compared to non-diabetic control group (101.99 +/- 68.32). There was no difference (p>0.05) in the salivary IL-8 level when subjects with Type I DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with T...ype I DM was correlated with the clinical parameters, no statistical significance was found Conclusion: An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.
Кључне речи:
Type 1 diabetes mellitus / periodontitis / children / cytokines / interleukin-8Извор:
Journal of Clinical Pediatric Dentistry, 2013, 37, 4, 377-380Издавач:
- Journal Pedodontics Inc, Birmingham
Финансирање / пројекти:
- Генетичка контрола и молекуларни механизми у малигним, инфламаторним и развојним патологијама орофацијалне регије (RS-MESTD-Basic Research (BR or ON)-175075)
- Интеракција етиопатогенетских механизама пародонтопатије и паериимплантитиса са системским болестима данашњице (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41008)
DOI: 10.17796/jcpd.37.4.l135531h4542gj66
ISSN: 1053-4628
PubMed: 24046985
WoS: 000335092800008
Scopus: 2-s2.0-84885932613
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Daković, Dragana AU - Čolić, Miodrag AU - Čakić, Saša AU - Mileusnić, Ivan AU - Hajduković, Zoran AU - Stamatović, Novak PY - 2013 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1852 AB - Objective: The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type I diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established Methods: Twenty children and adolescents with Type I DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. Results: The Salivary IL-8 level was statistically significantly (p lt 0.005) elevated in subjects with Type 1 DM (474.47 +/- 716.76) compared to non-diabetic control group (101.99 +/- 68.32). There was no difference (p>0.05) in the salivary IL-8 level when subjects with Type I DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type I DM was correlated with the clinical parameters, no statistical significance was found Conclusion: An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications. PB - Journal Pedodontics Inc, Birmingham T2 - Journal of Clinical Pediatric Dentistry T1 - Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus VL - 37 IS - 4 SP - 377 EP - 380 DO - 10.17796/jcpd.37.4.l135531h4542gj66 ER -
@article{ author = "Daković, Dragana and Čolić, Miodrag and Čakić, Saša and Mileusnić, Ivan and Hajduković, Zoran and Stamatović, Novak", year = "2013", abstract = "Objective: The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type I diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established Methods: Twenty children and adolescents with Type I DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. Results: The Salivary IL-8 level was statistically significantly (p lt 0.005) elevated in subjects with Type 1 DM (474.47 +/- 716.76) compared to non-diabetic control group (101.99 +/- 68.32). There was no difference (p>0.05) in the salivary IL-8 level when subjects with Type I DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type I DM was correlated with the clinical parameters, no statistical significance was found Conclusion: An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.", publisher = "Journal Pedodontics Inc, Birmingham", journal = "Journal of Clinical Pediatric Dentistry", title = "Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus", volume = "37", number = "4", pages = "377-380", doi = "10.17796/jcpd.37.4.l135531h4542gj66" }
Daković, D., Čolić, M., Čakić, S., Mileusnić, I., Hajduković, Z.,& Stamatović, N.. (2013). Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus. in Journal of Clinical Pediatric Dentistry Journal Pedodontics Inc, Birmingham., 37(4), 377-380. https://doi.org/10.17796/jcpd.37.4.l135531h4542gj66
Daković D, Čolić M, Čakić S, Mileusnić I, Hajduković Z, Stamatović N. Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus. in Journal of Clinical Pediatric Dentistry. 2013;37(4):377-380. doi:10.17796/jcpd.37.4.l135531h4542gj66 .
Daković, Dragana, Čolić, Miodrag, Čakić, Saša, Mileusnić, Ivan, Hajduković, Zoran, Stamatović, Novak, "Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus" in Journal of Clinical Pediatric Dentistry, 37, no. 4 (2013):377-380, https://doi.org/10.17796/jcpd.37.4.l135531h4542gj66 . .