Приказ основних података о документу
Gene-environment interaction between the MMP9 C-1562T promoter variant and cigarette smoke in the pathogenesis of chronic obstructive pulmonary disease
dc.creator | Stanković, Marija | |
dc.creator | Kojić, Snežana | |
dc.creator | Đorđević, Valentina | |
dc.creator | Tomović, Andrija | |
dc.creator | Nagorni-Obradović, Ljudmila | |
dc.creator | Petrović-Stanojević, Nataša | |
dc.creator | Mitic-Milikić, Marija | |
dc.creator | Radojković, Dragica | |
dc.date.accessioned | 2020-07-02T13:03:09Z | |
dc.date.available | 2020-07-02T13:03:09Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0893-6692 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2089 | |
dc.description.abstract | The aetiology of chronic obstructive pulmonary disease (COPD) is complex. While cigarette smoking is a well-established cause of COPD, a myriad of assessed genetic factors has given conflicting data. Since gene-environment interactions are thought to be implicated in aetiopathogenesis of COPD, we aimed to examine the matrix metalloproteinase (MMP) 9 C-1562T (rs3918242) functional variant and cigarette smoke in the pathogenesis of this disease. The distribution of the MMP9 C-1562T variant was analyzed in COPD patients and controls with normal pulmonary function from Serbia. Interaction between the C-1562T genetic variant and cigarette smoking was assessed using a case-control model. The response of the C-1562T promoter variant to cigarette smoke condensate (CSC) exposure was examined using a dual luciferase reporter assay. The frequency of T allele carriers was higher in the COPD group than in smoker controls (38.4% vs. 20%; OR=2.7, P=0.027). Interaction between the T allele and cigarette smoking was identified in COPD occurrence (OR=4.38, P=0.005) and severity (P=0.001). A functional analysis of the C-1562T variant demonstrated a dose-dependent and allele-specific response (P lt 0.01) to CSC. Significantly higher MMP9 promoter activity following CSC exposure was found for the promoter harboring the T allele compared to the promoter harboring the C allele (P lt 0.05). Our study is the first to reveal an interaction between the MMP9-1562T allele and cigarette smoke in COPD, emphasising gene-environment interactions as a possible cause of lung damage in the pathogenesis of COPD. Environ. Mol. Mutagen. 57:447-454, 2016. | en |
dc.publisher | Wiley, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS// | |
dc.rights | restrictedAccess | |
dc.source | Environmental & Molecular Mutagenesis | |
dc.subject | lung disease | en |
dc.subject | MMP9 | en |
dc.subject | cigarette smoke | en |
dc.subject | gene-environment interaction | en |
dc.title | Gene-environment interaction between the MMP9 C-1562T promoter variant and cigarette smoke in the pathogenesis of chronic obstructive pulmonary disease | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Станковић, Марија; Томовић, Aндрија; Којић, Снежана; Радојковић, Драгица; Ђорђевић, Валентина; Митиц-Миликић, Марија; Петровић-Станојевић, Наташа; Нагорни-Обрадовић, Људмила; | |
dc.citation.volume | 57 | |
dc.citation.issue | 6 | |
dc.citation.spage | 447 | |
dc.citation.epage | 454 | |
dc.citation.other | 57(6): 447-454 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000379953300003 | |
dc.identifier.doi | 10.1002/em.22025 | |
dc.identifier.pmid | 27270564 | |
dc.identifier.scopus | 2-s2.0-84978863694 | |
dc.type.version | publishedVersion |