Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study
2016
Аутори
Todorović, Vladimir S.Vasović, Miroslav
Andrić, Miroslav
Todorović, Ljubomir
Koković, Vladimir
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background: Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery. Material and Methods: Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analgesic, after the second operation. Analgesia was evaluated during first 24 hours postoperatively according to patients' reports about time of first pain appearance and additional analgesic consumption. Pain severity was rated using a 10 cm long visual analogue scale (VAS). Results: Intensity of posto...perative pain and postoperative analgesic consumption were significantly lower after the Fentanyl Transdermal System (FTS) was applied (p lt 0.05). Duration of postoperative analgesia was significantly higher with FTS when compared to control treatment (p lt 0.05). Conclusions: Based on the results of this preliminary study, transdermal system with fentanyl significantly reduced postoperative pain after third molar surgery.
Кључне речи:
Analgesia / fentanyl / transdermal administration / third molar surgery / acute pain / postoperative careИзвор:
Medicina Oral Patologia Oral Y Cirugia Bucal, 2016, 21, 5, E621-E625Издавач:
- Medicina Oral S L, Valencia
Финансирање / пројекти:
- Интеракција етиопатогенетских механизама пародонтопатије и паериимплантитиса са системским болестима данашњице (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41008)
DOI: 10.4317/medoral.21161
ISSN: 1698-6946
PubMed: 27475691
WoS: 000391193600013
Scopus: 2-s2.0-84985914375
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Todorović, Vladimir S. AU - Vasović, Miroslav AU - Andrić, Miroslav AU - Todorović, Ljubomir AU - Koković, Vladimir PY - 2016 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2121 AB - Background: Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery. Material and Methods: Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analgesic, after the second operation. Analgesia was evaluated during first 24 hours postoperatively according to patients' reports about time of first pain appearance and additional analgesic consumption. Pain severity was rated using a 10 cm long visual analogue scale (VAS). Results: Intensity of postoperative pain and postoperative analgesic consumption were significantly lower after the Fentanyl Transdermal System (FTS) was applied (p lt 0.05). Duration of postoperative analgesia was significantly higher with FTS when compared to control treatment (p lt 0.05). Conclusions: Based on the results of this preliminary study, transdermal system with fentanyl significantly reduced postoperative pain after third molar surgery. PB - Medicina Oral S L, Valencia T2 - Medicina Oral Patologia Oral Y Cirugia Bucal T1 - Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study VL - 21 IS - 5 SP - E621 EP - E625 DO - 10.4317/medoral.21161 ER -
@article{ author = "Todorović, Vladimir S. and Vasović, Miroslav and Andrić, Miroslav and Todorović, Ljubomir and Koković, Vladimir", year = "2016", abstract = "Background: Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery. Material and Methods: Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analgesic, after the second operation. Analgesia was evaluated during first 24 hours postoperatively according to patients' reports about time of first pain appearance and additional analgesic consumption. Pain severity was rated using a 10 cm long visual analogue scale (VAS). Results: Intensity of postoperative pain and postoperative analgesic consumption were significantly lower after the Fentanyl Transdermal System (FTS) was applied (p lt 0.05). Duration of postoperative analgesia was significantly higher with FTS when compared to control treatment (p lt 0.05). Conclusions: Based on the results of this preliminary study, transdermal system with fentanyl significantly reduced postoperative pain after third molar surgery.", publisher = "Medicina Oral S L, Valencia", journal = "Medicina Oral Patologia Oral Y Cirugia Bucal", title = "Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study", volume = "21", number = "5", pages = "E621-E625", doi = "10.4317/medoral.21161" }
Todorović, V. S., Vasović, M., Andrić, M., Todorović, L.,& Koković, V.. (2016). Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study. in Medicina Oral Patologia Oral Y Cirugia Bucal Medicina Oral S L, Valencia., 21(5), E621-E625. https://doi.org/10.4317/medoral.21161
Todorović VS, Vasović M, Andrić M, Todorović L, Koković V. Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study. in Medicina Oral Patologia Oral Y Cirugia Bucal. 2016;21(5):E621-E625. doi:10.4317/medoral.21161 .
Todorović, Vladimir S., Vasović, Miroslav, Andrić, Miroslav, Todorović, Ljubomir, Koković, Vladimir, "Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study" in Medicina Oral Patologia Oral Y Cirugia Bucal, 21, no. 5 (2016):E621-E625, https://doi.org/10.4317/medoral.21161 . .