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Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts
dc.creator | Velicković, Milena | |
dc.creator | Pejnović, Nada | |
dc.creator | Petrović, Renata | |
dc.creator | Mitrović, Slobodanka | |
dc.creator | Jeftić, Ilija | |
dc.creator | Kanjevac, Tatjana | |
dc.creator | Lukić, Aleksandra | |
dc.date.accessioned | 2020-07-02T13:06:00Z | |
dc.date.available | 2020-07-02T13:06:00Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0904-2512 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2135 | |
dc.description.abstract | BACKGROUND: Interleukin-33 (IL-33) is a recently identified cytokine belonging to the IL-1 family and ligand for the IL-1 receptor-related protein ST2. IL-33/ST2 signaling plays a critical role in allergy, autoimmunity, and chronic inflammatory disorders, but its role in the pathogenesis of periapical lesions is unknown. We aimed to investigate the expression patterns of IL-33 and ST2 in human periapical lesions. METHODS: Periapical lesions (n = 36) and healthy periapical tissues (n = 10) were evaluated by immunohistochemistry using antibodies specific for human IL-33 and ST2. Lesion samples were further analyzed by double immunofluorescence to assess IL-33/ST2 co-expression. RESULTS: The numbers of IL-33- and ST2-positive fibroblasts were significantly higher in periapical lesions compared to healthy periapical tissues (both P lt 0.05), while the numbers of IL-33-and ST2-positive endothelial cells were similar (both P > 0.05). There were no significant differences in the numbers of IL-33-and ST2-positive fibroblasts and endothelial cells between periapical granulomas and radicular cysts (all P > 0.05). Similarly, numbers of ST2-positive mononuclear cells did not differ between periapical granulomas and radicular cysts (P > 0.05). The majority of epithelial cells in radicular cysts were IL-33 positive, while the small proportion of epithelial cells was ST2 positive. Double immunofluorescence analysis revealed IL-33/ST2 co-expression in fibroblasts and endothelial cells. CONCLUSIONS: IL-33 and ST2 are expressed in periapical granulomas and radicular cysts. Increased numbers of IL-33-and ST2-positive fibroblasts in periapical lesions when compared to healthy periapical tissues suggest that IL-33/ST2 signaling may be involved in periapical inflammation and tissue fibrosis. | en |
dc.publisher | Wiley, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175071/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Oral Pathology & Medicine | |
dc.subject | inflammation | en |
dc.subject | interleukin-33 | en |
dc.subject | periapical granuloma | en |
dc.subject | radicular cyst | en |
dc.subject | ST2 | en |
dc.title | Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Петровић, Рената; Пејновић, Нада; Митровић, Слободанка; Јефтић, Илија; Кањевац, Татјана; Лукић, Aлександра; Велицковић, Милена; | |
dc.citation.volume | 45 | |
dc.citation.issue | 1 | |
dc.citation.spage | 70 | |
dc.citation.epage | 76 | |
dc.citation.other | 45(1): 70-76 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000369990100012 | |
dc.identifier.doi | 10.1111/jop.12312 | |
dc.identifier.pmid | 25677987 | |
dc.identifier.scopus | 2-s2.0-84955747679 | |
dc.type.version | publishedVersion |