Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species
Само за регистроване кориснике
2016
Аутори
Jakovljević, AleksandarAndrić, Miroslav
Miletić, Maja
Beljić-Ivanović, Katarina
Knežević, Aleksandra
Mojsilović, Slavko
Milašin, Jelena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and... antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.
Извор:
Medical Hypotheses, 2016, 94, 40-42Издавач:
- Churchill Livingstone, Edinburgh
Финансирање / пројекти:
- Генетичка контрола и молекуларни механизми у малигним, инфламаторним и развојним патологијама орофацијалне регије (RS-MESTD-Basic Research (BR or ON)-175075)
DOI: 10.1016/j.mehy.2016.06.020
ISSN: 0306-9877
PubMed: 27515196
WoS: 000382341300010
Scopus: 2-s2.0-84975879198
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Jakovljević, Aleksandar AU - Andrić, Miroslav AU - Miletić, Maja AU - Beljić-Ivanović, Katarina AU - Knežević, Aleksandra AU - Mojsilović, Slavko AU - Milašin, Jelena PY - 2016 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2147 AB - Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed. PB - Churchill Livingstone, Edinburgh T2 - Medical Hypotheses T1 - Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species VL - 94 SP - 40 EP - 42 DO - 10.1016/j.mehy.2016.06.020 ER -
@article{ author = "Jakovljević, Aleksandar and Andrić, Miroslav and Miletić, Maja and Beljić-Ivanović, Katarina and Knežević, Aleksandra and Mojsilović, Slavko and Milašin, Jelena", year = "2016", abstract = "Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.", publisher = "Churchill Livingstone, Edinburgh", journal = "Medical Hypotheses", title = "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species", volume = "94", pages = "40-42", doi = "10.1016/j.mehy.2016.06.020" }
Jakovljević, A., Andrić, M., Miletić, M., Beljić-Ivanović, K., Knežević, A., Mojsilović, S.,& Milašin, J.. (2016). Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses Churchill Livingstone, Edinburgh., 94, 40-42. https://doi.org/10.1016/j.mehy.2016.06.020
Jakovljević A, Andrić M, Miletić M, Beljić-Ivanović K, Knežević A, Mojsilović S, Milašin J. Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses. 2016;94:40-42. doi:10.1016/j.mehy.2016.06.020 .
Jakovljević, Aleksandar, Andrić, Miroslav, Miletić, Maja, Beljić-Ivanović, Katarina, Knežević, Aleksandra, Mojsilović, Slavko, Milašin, Jelena, "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species" in Medical Hypotheses, 94 (2016):40-42, https://doi.org/10.1016/j.mehy.2016.06.020 . .