Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies
2019
Аутори
Petrović, MilanJelovac, Drago
Antić, Svetlana
Antunović, Marija
Lukić, Nikola
Sabani, Melvil
Mudrak, Joerg
Jezdić, Zoran
Pucar, Ana
Stefanović, Aleksandar
Kuzmanović, Čedomir
Nikolić, Danilo
Konstantinović, Vitomir
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality. MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively. MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously. Stages I..., II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively. Mandible was affected in 23 (72%) patients. MRONJ was treated in our department by conservative and surgical modality. In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group. The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome. Comprehensive treatment protocol and further randomized studies are necessary for further improvements.
Извор:
Biomed Research International, 2019, 2019Издавач:
- Hindawi Ltd, London
Финансирање / пројекти:
- Генетичка контрола и молекуларни механизми у малигним, инфламаторним и развојним патологијама орофацијалне регије (RS-MESTD-Basic Research (BR or ON)-175075)
- Функционални, функционализовани и усавршени нано материјали (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45005)
DOI: 10.1155/2019/8345309
ISSN: 2314-6133
PubMed: 31011580
WoS: 000463067100001
Scopus: 2-s2.0-85064087470
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Petrović, Milan AU - Jelovac, Drago AU - Antić, Svetlana AU - Antunović, Marija AU - Lukić, Nikola AU - Sabani, Melvil AU - Mudrak, Joerg AU - Jezdić, Zoran AU - Pucar, Ana AU - Stefanović, Aleksandar AU - Kuzmanović, Čedomir AU - Nikolić, Danilo AU - Konstantinović, Vitomir PY - 2019 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2443 AB - This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality. MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively. MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously. Stages I, II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively. Mandible was affected in 23 (72%) patients. MRONJ was treated in our department by conservative and surgical modality. In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group. The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome. Comprehensive treatment protocol and further randomized studies are necessary for further improvements. PB - Hindawi Ltd, London T2 - Biomed Research International T1 - Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies VL - 2019 DO - 10.1155/2019/8345309 ER -
@article{ author = "Petrović, Milan and Jelovac, Drago and Antić, Svetlana and Antunović, Marija and Lukić, Nikola and Sabani, Melvil and Mudrak, Joerg and Jezdić, Zoran and Pucar, Ana and Stefanović, Aleksandar and Kuzmanović, Čedomir and Nikolić, Danilo and Konstantinović, Vitomir", year = "2019", abstract = "This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality. MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively. MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously. Stages I, II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively. Mandible was affected in 23 (72%) patients. MRONJ was treated in our department by conservative and surgical modality. In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group. The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome. Comprehensive treatment protocol and further randomized studies are necessary for further improvements.", publisher = "Hindawi Ltd, London", journal = "Biomed Research International", title = "Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies", volume = "2019", doi = "10.1155/2019/8345309" }
Petrović, M., Jelovac, D., Antić, S., Antunović, M., Lukić, N., Sabani, M., Mudrak, J., Jezdić, Z., Pucar, A., Stefanović, A., Kuzmanović, Č., Nikolić, D.,& Konstantinović, V.. (2019). Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. in Biomed Research International Hindawi Ltd, London., 2019. https://doi.org/10.1155/2019/8345309
Petrović M, Jelovac D, Antić S, Antunović M, Lukić N, Sabani M, Mudrak J, Jezdić Z, Pucar A, Stefanović A, Kuzmanović Č, Nikolić D, Konstantinović V. Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. in Biomed Research International. 2019;2019. doi:10.1155/2019/8345309 .
Petrović, Milan, Jelovac, Drago, Antić, Svetlana, Antunović, Marija, Lukić, Nikola, Sabani, Melvil, Mudrak, Joerg, Jezdić, Zoran, Pucar, Ana, Stefanović, Aleksandar, Kuzmanović, Čedomir, Nikolić, Danilo, Konstantinović, Vitomir, "Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies" in Biomed Research International, 2019 (2019), https://doi.org/10.1155/2019/8345309 . .