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Immunoreactivity to food protein in pathogenesis of recurrent oral ulceration
Imunoreaktivnost na proteine hrane u etiopatogenezi rekurentnih oralnih ulceracija
dc.contributor.advisor | Janković, Ljiljana | |
dc.contributor.other | Juranić, Zorica | |
dc.creator | Besu Žižak, Irina | |
dc.date.accessioned | 2020-07-02T11:15:40Z | |
dc.date.available | 2020-07-02T11:15:40Z | |
dc.date.issued | 2010 | |
dc.identifier.uri | http://eteze.bg.ac.rs/application/showtheses?thesesId=621 | |
dc.identifier.uri | https://fedorabg.bg.ac.rs/fedora/get/o:6807/bdef:Content/download | |
dc.identifier.uri | http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=37196047 | |
dc.identifier.uri | http://nardus.mpn.gov.rs/123456789/2690 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/948 | |
dc.description.abstract | Based on a complete analysis of the results , we came to the following conclusions: 1. Characteristics of ROU: • The experimental group consisted of 38% men and 62% women. • The average age of the experimental group was 40.32 years. • The most common localization (53%) of ROU is the buccal and labial mucosa , then the tong (14%) and the whole mouth in 13% of patients. • In 86% of cases, the characteristics of ROU corresponded to clinical picture of aphthae minor, while in 14% of cases corresponded to aphthae major. • Over half of the patients (58%) at the time of the physical examination had 1-5 ulcerations in the oral cavity, 32% had from 5-10, while 10% had more than 10 ulcerations in the oral cavity. • In 52% of patients, ROU first emerged several years ago, in 40% of them for more than a year, while in 6% change first occurred in the period of 1-6 months ago, only one respondent (2%) stated that the ulcers first appeared over a period of 6-12 months before. • ROU relapse appeared from one month in 40% of patients, 30% of them stated incidence of recurrence of 2-5 times in 6 months, while in 18% of patients these changes occurred several times per month, the lowest number of patients (12%) stated that the recurrence comes from 1-3 times per year. • In the 86% of patients ROU heal over a period of 7-14 days , while in 14% of cases, heal more than one month . 2. Sensitization to food proteins: • In 14 % of patients with ROU elevated humoral immunoreactivity to gliadin is registered. • Elevated humoral immunoreactivity to the total cow milk protein was detected in more than half (72 %) patients with ROU. • Serum antibodies in the elevated concentration was present against: -α - casein in 72%, -β- casein in 62%, -κ- casein in 52%, -α - lactalbumin in 18%, - lactoferrin in 20%, -β - lactoglobulin A and 24% in -β - lactoglobulin B in 30% of patients. 3. Based on these results we conclude that cow's milk protein may be one of the etiological factors in the development of ROU . | en |
dc.description.abstract | Na osnovu kompletne analize dobijenih rezultata, došli smo do sledećih zaključaka: 1. Karakteristike ROU: • Eksperimentalnu grupu je činilo 38% muškaraca i 62% žena. • Prosečna starost eksperimentalne grupe je iznosila 40.32 godine. • Najzastupljenija lokalizacija (53%) ROU su bukalna i labijalna sluzokoža, zatim jezik sa 14% i cela usta u 13% pacijenata. • U 86% slučajeva karakteristike ROU su odgovarale kliničkoj slici afta minor, dok su u 14% slučajeva odgovarale aftama major. • Više od polovine pacijenata (58%) je u momentu kliničkog pregleda imalo od 1-5 ulceracija u usnoj duplji, 32% je imalo od 5-10 promena, dok je 10% imalo više od 10 ulceracija u ustima. • Kod 52% pacijenata, ROU su se prvi put pojavile pre više godina, kod 40% njih pre više od godinu dana, dok su se u 6% slučajeva promene prvi put javile u periodu od pre 1-6 meseci; samo jedan ispitanik (2%) je izjavio da su se ulceracije prvi put pojavile u periodu od pre 6-12 meseci. • Recidiv ROU se javljao jednom mesečno u 40% pacijenata, 30% njih je navelo da je učestalost recidiva od 2-5 puta u toku 6 meseci, dok su se u 18% njih promene javljale više puta mesečno; najmanji broj pacijenata (12%) je izjavio da do recidiva dolazi od 1-3 puta u toku jedne godine. • U 86% pacijenata ROU zarastaju u periodu od 7-14 dana, dok u 14% slučajeva zarastaju duže od mesec dana. 2. Preosetljivost na proteine hrane: • Kod 14% ispitanih pacijenata sa ROU registrovana je povišena humoralna imunoreaktivnost na gliadin. • Povišena humoralna imunoreaktivnost na ukupne proteine kravljeg mleka je detektovana kod više od polovine (72%) pacijenata sa ROU. • Serumska antitela su u povišenoj koncentraciji bila prisutna na: - α-kazein u 72%, - β-kazein u 62%, - κ-kazein u 52%, - α-laktalbumin u 18%, - laktoferin u 20%, - β-laktoglobulin A u 24% i - β-laktoglobulin B u 30%. 3. Na osnovu dobijenih rezultata konstatujemo da proteini kravljeg mleka mogu biti jedan od etioloških faktora u nastanku ROU. | sr |
dc.language | sr | |
dc.publisher | Univerzitet u Beogradu, Stomatološki fakultet | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | immunoreactivity | en |
dc.subject | food antigens | en |
dc.subject | milk | en |
dc.subject | gliadin | en |
dc.subject | recurrent aphthous ulcers | en |
dc.subject | imunoreaktivnost | sr |
dc.subject | antigeni hrane | sr |
dc.subject | mleko | sr |
dc.subject | gliadin | sr |
dc.subject | rekurentne aftozne ulceracije | sr |
dc.title | Immunoreactivity to food protein in pathogenesis of recurrent oral ulceration | en |
dc.title | Imunoreaktivnost na proteine hrane u etiopatogenezi rekurentnih oralnih ulceracija | sr |
dc.type | doctoralThesis | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Јанковић, Љиљана; Јуранић, Зорица; Бесу Жижак, Ирина; Имунореактивност на протеине хране у етиопатогенези рекурентних оралних улцерација; Имунореактивност на протеине хране у етиопатогенези рекурентних оралних улцерација; | |
dc.identifier.fulltext | https://smile.stomf.bg.ac.rs/bitstream/id/1031/943.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_2690 | |
dc.type.version | publishedVersion |