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Analysis of the anti-apoptotic protein bcl-2 in oral squamous cell carcinoma
Analiza antiapoptotskog proteina bcl-2 u skvamocelularnom karcinomu usne regije
dc.creator | Popović, Branka | |
dc.creator | Jekić, Biljana | |
dc.creator | Novaković, Ivana | |
dc.creator | Milašin, Jelena | |
dc.date.accessioned | 2020-07-02T12:16:18Z | |
dc.date.available | 2020-07-02T12:16:18Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0039-1743 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1371 | |
dc.description.abstract | Aim: The aim of this study was to analyze the presence of the anti-apoptotic protein bcl-2 in oral squamous cell carcinoma and determine its potential role in the development and progression of this type of tumor. Materials and methods: The expression of bcl-2 was determined in 28 paraffin blocks of oral squamous cell carcinoma using the immunohistochemical method. The percentage of the immuno-reactive cells in positively stained tumor regions was determined using the microscopic analysis and Ozaria software. Results: Positive immunohistochemical test was observed in 19 out of 28 samples (68%) as follows: in 11 samples there was a low (+), in four a moderate (++) and in the last four a high percentage (+++) of stained cells. In the group of patients at the low stage of the disease (T2), 50% of tumor samples showed bcl-2 protein expression whereas in the higher stages (T3 and T4) of positively stained samples, this percentage was 67%. There was a trend of an increasing number of cells with positive bcl-2 staining in the tumors of higher clinical stages but not the level of bcl-2 protein expression. Conclusion: Both parameters, the presence of bcl-2 staining and the percentage of cells with bcl-2 immunoexpression, may act as additional prognostic parameters that indicate an increased proliferative tumor potential. | en |
dc.description.abstract | Cilj ove studije bio je analiza prisustva antiapoptotskog proteina bcl-2 u skvamocelularnom karcinomu usne regije i procena njegove eventualne uloge u razvoju i progresiji ove vrste tumora. Materijal i metode: Na uzorku od 28 parafinskih blokova skvamocelularnog karcinoma usne regije, imunohistohemijskom metodom ispitan je ekspresioni status bcl-2 proteina. Mikroskopskom analizom i primenom softvera- Ozaria određen je procenat imunoreaktivnih ćelija u pozitivno obojenim tumorskim regijama. Rezultat: Pozitivnu imunohistohemijsku obojenost pokazalo je 19 od 28 uzoraka (68%) i to: 11 je bilo sa niskim (+), 4 sa srednjim (++) i 4 sa visokim procentom (+++) obojenih ćelija. U grupi pacijenata niskog stadijuma (T2) 50 % uzoraka tumora je pokazivalo ekspresiju bcl-2 proteina dok je u višim stadijumima (T3 i T4) pozitivnih uzoraka bilo 67%. Postojao je trend porasta broja ćelija sa pozitivnom bcl-2 obojenošću kod tumora u višim kliničkim stadijumima, ali ne i povećan nivo ekspresije bcl-2 proteina. Zaključak: Oba parametra, prisustvo bcl-2 obojenosti i procenat ćelija sa bcl-2 imunoekspresijom, mogu predstavljati dopunske prognostičke parametre koji ukazuju na povećan proliferativni potencijal tumora. | sr |
dc.publisher | Srpsko lekarsko društvo - Stomatološka sekcija, Beograd | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-sa/4.0/ | |
dc.source | Stomatološki glasnik Srbije | |
dc.subject | bcl-2 protein | en |
dc.subject | apoptosis | en |
dc.subject | oral squamous cell carcinoma | en |
dc.subject | bcl-2 protein | sr |
dc.subject | apoptoza | sr |
dc.subject | skvamocelularni karcinomusne regije | sr |
dc.title | Analysis of the anti-apoptotic protein bcl-2 in oral squamous cell carcinoma | en |
dc.title | Analiza antiapoptotskog proteina bcl-2 u skvamocelularnom karcinomu usne regije | sr |
dc.type | article | |
dc.rights.license | BY-SA | |
dcterms.abstract | Поповић, Бранка; Новаковић, Ивана; Јекић, Биљана; Милашин, Јелена; Aнализа антиапоптотског протеина бцл-2 у сквамоцелуларном карциному усне регије; Aнализа антиапоптотског протеина бцл-2 у сквамоцелуларном карциному усне регије; | |
dc.citation.volume | 54 | |
dc.citation.issue | 3 | |
dc.citation.spage | 153 | |
dc.citation.epage | 159 | |
dc.citation.other | 54(3): 153-159 | |
dc.identifier.doi | 10.2298/SGS0703153P | |
dc.identifier.fulltext | https://smile.stomf.bg.ac.rs/bitstream/id/207/1366.pdf | |
dc.type.version | publishedVersion |