Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication
Само за регистроване кориснике
2008
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors... and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.
Кључне речи:
lead / magnesium / calcium / hard tissuesИзвор:
Magnesium Research, 2008, 21, 1, 43-50
DOI: 10.1684/mrh.2008.0122
ISSN: 0953-1424
PubMed: 18557133
WoS: 000255166500005
Scopus: 2-s2.0-42549142194
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Todorović, Tatjana AU - Vujanović, Dragana AU - Dožić, Ivan AU - Petković-Ćurčin, Aleksandra PY - 2008 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1441 AB - Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg. T2 - Magnesium Research T1 - Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication VL - 21 IS - 1 SP - 43 EP - 50 DO - 10.1684/mrh.2008.0122 ER -
@article{ author = "Todorović, Tatjana and Vujanović, Dragana and Dožić, Ivan and Petković-Ćurčin, Aleksandra", year = "2008", abstract = "Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.", journal = "Magnesium Research", title = "Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication", volume = "21", number = "1", pages = "43-50", doi = "10.1684/mrh.2008.0122" }
Todorović, T., Vujanović, D., Dožić, I.,& Petković-Ćurčin, A.. (2008). Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication. in Magnesium Research, 21(1), 43-50. https://doi.org/10.1684/mrh.2008.0122
Todorović T, Vujanović D, Dožić I, Petković-Ćurčin A. Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication. in Magnesium Research. 2008;21(1):43-50. doi:10.1684/mrh.2008.0122 .
Todorović, Tatjana, Vujanović, Dragana, Dožić, Ivan, Petković-Ćurčin, Aleksandra, "Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication" in Magnesium Research, 21, no. 1 (2008):43-50, https://doi.org/10.1684/mrh.2008.0122 . .