Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection
Само за регистроване кориснике
2010
Аутори
Andrić, Miroslav![](/themes/MirageSMILE/images/orcid.png)
Dožić, Branko
![](/themes/MirageSMILE/images/orcid.png)
Popović, Branka
![](/themes/MirageSMILE/images/orcid.png)
Stefanović, D.
Basta-Jovanović, Gordana
![](/themes/MirageSMILE/images/orcid.png)
Đogo, N.
Andjus, P.
Milašin, Jelena
![](/themes/MirageSMILE/images/orcid.png)
Чланак у часопису (Објављена верзија)
![](/themes/MirageSMILE//images/creativecommons/arr.png)
Метаподаци
Приказ свих података о документуАпстракт
Objectives: The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts - periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus presence within these cysts. Materials and methods: Samples of 10 odontogenic keratocysts (five positive and five negative for the presence of cytomegalovirus, as determined by polymerase chain reaction) and 10 periapical cysts (five positive and five negative for the cytomegalovirus presence) were analysed. The expression of survivin was assessed by immunohistochemical methods, using monoclonal antibody that selectively recognizes the cytoplasmic form of survivin. Results: All 10 odontogenic keratocysts showed immunostaining for survivin, while all 10 periapical cysts were negative for its presence. There was no correlation between cytomegalovirus presence and expression ...of survivin within odontogenic keratocysts. Conclusion: Survivin may contribute to the aggressive behavior of odontogenic keratocysts, and thus support the emerging opinion of their neoplastic nature.
Кључне речи:
survivin expression / odontogenic keratocyst / keratocystic odontogenic tumor / cytomegalovirus / periapical cystИзвор:
Oral Diseases, 2010, 16, 2, 156-159Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- School of Dentistry, University of Belgrade
- Биофизичко неуропрофилирање на експерименталним моделима оштећења и опоравка централног нервног система (RS-MESTD-MPN2006-2010-143054)
DOI: 10.1111/j.1601-0825.2009.01612.x
ISSN: 1354-523X
PubMed: 19659890
WoS: 000274713400006
Scopus: 2-s2.0-77249173888
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Andrić, Miroslav AU - Dožić, Branko AU - Popović, Branka AU - Stefanović, D. AU - Basta-Jovanović, Gordana AU - Đogo, N. AU - Andjus, P. AU - Milašin, Jelena PY - 2010 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1531 AB - Objectives: The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts - periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus presence within these cysts. Materials and methods: Samples of 10 odontogenic keratocysts (five positive and five negative for the presence of cytomegalovirus, as determined by polymerase chain reaction) and 10 periapical cysts (five positive and five negative for the cytomegalovirus presence) were analysed. The expression of survivin was assessed by immunohistochemical methods, using monoclonal antibody that selectively recognizes the cytoplasmic form of survivin. Results: All 10 odontogenic keratocysts showed immunostaining for survivin, while all 10 periapical cysts were negative for its presence. There was no correlation between cytomegalovirus presence and expression of survivin within odontogenic keratocysts. Conclusion: Survivin may contribute to the aggressive behavior of odontogenic keratocysts, and thus support the emerging opinion of their neoplastic nature. PB - Wiley, Hoboken T2 - Oral Diseases T1 - Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection VL - 16 IS - 2 SP - 156 EP - 159 DO - 10.1111/j.1601-0825.2009.01612.x ER -
@article{ author = "Andrić, Miroslav and Dožić, Branko and Popović, Branka and Stefanović, D. and Basta-Jovanović, Gordana and Đogo, N. and Andjus, P. and Milašin, Jelena", year = "2010", abstract = "Objectives: The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts - periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus presence within these cysts. Materials and methods: Samples of 10 odontogenic keratocysts (five positive and five negative for the presence of cytomegalovirus, as determined by polymerase chain reaction) and 10 periapical cysts (five positive and five negative for the cytomegalovirus presence) were analysed. The expression of survivin was assessed by immunohistochemical methods, using monoclonal antibody that selectively recognizes the cytoplasmic form of survivin. Results: All 10 odontogenic keratocysts showed immunostaining for survivin, while all 10 periapical cysts were negative for its presence. There was no correlation between cytomegalovirus presence and expression of survivin within odontogenic keratocysts. Conclusion: Survivin may contribute to the aggressive behavior of odontogenic keratocysts, and thus support the emerging opinion of their neoplastic nature.", publisher = "Wiley, Hoboken", journal = "Oral Diseases", title = "Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection", volume = "16", number = "2", pages = "156-159", doi = "10.1111/j.1601-0825.2009.01612.x" }
Andrić, M., Dožić, B., Popović, B., Stefanović, D., Basta-Jovanović, G., Đogo, N., Andjus, P.,& Milašin, J.. (2010). Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection. in Oral Diseases Wiley, Hoboken., 16(2), 156-159. https://doi.org/10.1111/j.1601-0825.2009.01612.x
Andrić M, Dožić B, Popović B, Stefanović D, Basta-Jovanović G, Đogo N, Andjus P, Milašin J. Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection. in Oral Diseases. 2010;16(2):156-159. doi:10.1111/j.1601-0825.2009.01612.x .
Andrić, Miroslav, Dožić, Branko, Popović, Branka, Stefanović, D., Basta-Jovanović, Gordana, Đogo, N., Andjus, P., Milašin, Jelena, "Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection" in Oral Diseases, 16, no. 2 (2010):156-159, https://doi.org/10.1111/j.1601-0825.2009.01612.x . .