T4 Glottic carcinoma: oncological results and survival rate
Нема приказа
Аутори
Jancić, SlavisaZivić, Miško
Radovanović, Zoran
Miličić, Biljana
Đinđić, Nataša
Đinđić, Boris
Jančić, Snežana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objectives/Background: The best course of action in the case of T4 glottic carcinoma is chosen for each individual case. The aim of this study was to evaluate the potential prognostic factors and influence of postoperative and radical radiotherapy on the survival rate of patients suffering from T4 glottic carcinoma and to analyze the most appropriate conservative treatment for these patients. Methods: Study Design: A retrospective study (1995-2000) enrolled 63 patients with squamo-cellular glottic cancer in T4N1M0 stage, monitored for 5 years, divided into two groups: 30 postoperatively irradiated patients and 33 radically irradiated patients. Analysed variables were: age, sex, total therapeutical dose, number of fractions, dose per fraction and type of radiotherapeutical treatment. Standard therapeutical fractionation regimens were used, with daily sessions of 2-3 Gy, five times a week. Radiotherapy consisted of mega-voltage 10 MEV X-ray therapy. Log Rank test, Kaplan-Meier survival s...tudy, t-test, Pearson X2 - test and Cox regression were used in order to select the factors with independent effect. Results: Multivariate analysis demonstrated that none of the predictors, not even the type of radiation therapy, were statistically significant, with independent influence on survival. Conclusion: There is no significant difference in survival of patients with T4 glottic carcinoma among postoperatively and radically irradiated patients. Our results imply that the optimal radiotherapeutic modality for these patients is a total therapeutical dose no less than 65 Gy and daily fractionation with dose no less than 2,51Gy.
Кључне речи:
T4 glottic cancer / prognostic factors / radical radiotherapy / postoperative radiotherapy / survivalИзвор:
HealthMED, 2011, 5, 6, 1737-1743Издавач:
- Drunpp-Sarajevo, Sarajevo
Финансирање / пројекти:
- Мониторинг електромагнетних зрачења мобилних телекомуникационих система у животној средини, анализа молекуларних механизама и биомаркера оштећења код хроничне изложености са развојем модела за процену ризика и метода за заштиту (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43012)
- Превентивни, терапијски и етички приступ преклиничким и клиничким истраживањима гена и модулатора редокс ћелијске сигнализације у имунском, инфламаторном и пролиферативном одговору ћелије (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41018)
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Jancić, Slavisa AU - Zivić, Miško AU - Radovanović, Zoran AU - Miličić, Biljana AU - Đinđić, Nataša AU - Đinđić, Boris AU - Jančić, Snežana PY - 2011 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1611 AB - Objectives/Background: The best course of action in the case of T4 glottic carcinoma is chosen for each individual case. The aim of this study was to evaluate the potential prognostic factors and influence of postoperative and radical radiotherapy on the survival rate of patients suffering from T4 glottic carcinoma and to analyze the most appropriate conservative treatment for these patients. Methods: Study Design: A retrospective study (1995-2000) enrolled 63 patients with squamo-cellular glottic cancer in T4N1M0 stage, monitored for 5 years, divided into two groups: 30 postoperatively irradiated patients and 33 radically irradiated patients. Analysed variables were: age, sex, total therapeutical dose, number of fractions, dose per fraction and type of radiotherapeutical treatment. Standard therapeutical fractionation regimens were used, with daily sessions of 2-3 Gy, five times a week. Radiotherapy consisted of mega-voltage 10 MEV X-ray therapy. Log Rank test, Kaplan-Meier survival study, t-test, Pearson X2 - test and Cox regression were used in order to select the factors with independent effect. Results: Multivariate analysis demonstrated that none of the predictors, not even the type of radiation therapy, were statistically significant, with independent influence on survival. Conclusion: There is no significant difference in survival of patients with T4 glottic carcinoma among postoperatively and radically irradiated patients. Our results imply that the optimal radiotherapeutic modality for these patients is a total therapeutical dose no less than 65 Gy and daily fractionation with dose no less than 2,51Gy. PB - Drunpp-Sarajevo, Sarajevo T2 - HealthMED T1 - T4 Glottic carcinoma: oncological results and survival rate VL - 5 IS - 6 SP - 1737 EP - 1743 UR - https://hdl.handle.net/21.15107/rcub_smile_1611 ER -
@article{ author = "Jancić, Slavisa and Zivić, Miško and Radovanović, Zoran and Miličić, Biljana and Đinđić, Nataša and Đinđić, Boris and Jančić, Snežana", year = "2011", abstract = "Objectives/Background: The best course of action in the case of T4 glottic carcinoma is chosen for each individual case. The aim of this study was to evaluate the potential prognostic factors and influence of postoperative and radical radiotherapy on the survival rate of patients suffering from T4 glottic carcinoma and to analyze the most appropriate conservative treatment for these patients. Methods: Study Design: A retrospective study (1995-2000) enrolled 63 patients with squamo-cellular glottic cancer in T4N1M0 stage, monitored for 5 years, divided into two groups: 30 postoperatively irradiated patients and 33 radically irradiated patients. Analysed variables were: age, sex, total therapeutical dose, number of fractions, dose per fraction and type of radiotherapeutical treatment. Standard therapeutical fractionation regimens were used, with daily sessions of 2-3 Gy, five times a week. Radiotherapy consisted of mega-voltage 10 MEV X-ray therapy. Log Rank test, Kaplan-Meier survival study, t-test, Pearson X2 - test and Cox regression were used in order to select the factors with independent effect. Results: Multivariate analysis demonstrated that none of the predictors, not even the type of radiation therapy, were statistically significant, with independent influence on survival. Conclusion: There is no significant difference in survival of patients with T4 glottic carcinoma among postoperatively and radically irradiated patients. Our results imply that the optimal radiotherapeutic modality for these patients is a total therapeutical dose no less than 65 Gy and daily fractionation with dose no less than 2,51Gy.", publisher = "Drunpp-Sarajevo, Sarajevo", journal = "HealthMED", title = "T4 Glottic carcinoma: oncological results and survival rate", volume = "5", number = "6", pages = "1737-1743", url = "https://hdl.handle.net/21.15107/rcub_smile_1611" }
Jancić, S., Zivić, M., Radovanović, Z., Miličić, B., Đinđić, N., Đinđić, B.,& Jančić, S.. (2011). T4 Glottic carcinoma: oncological results and survival rate. in HealthMED Drunpp-Sarajevo, Sarajevo., 5(6), 1737-1743. https://hdl.handle.net/21.15107/rcub_smile_1611
Jancić S, Zivić M, Radovanović Z, Miličić B, Đinđić N, Đinđić B, Jančić S. T4 Glottic carcinoma: oncological results and survival rate. in HealthMED. 2011;5(6):1737-1743. https://hdl.handle.net/21.15107/rcub_smile_1611 .
Jancić, Slavisa, Zivić, Miško, Radovanović, Zoran, Miličić, Biljana, Đinđić, Nataša, Đinđić, Boris, Jančić, Snežana, "T4 Glottic carcinoma: oncological results and survival rate" in HealthMED, 5, no. 6 (2011):1737-1743, https://hdl.handle.net/21.15107/rcub_smile_1611 .