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Evidence for involvement of central vasopressin V1b and V2 receptors in stress-induced baroreflex desensitization
dc.creator | Milutinović-Smiljanić, Sanja | |
dc.creator | Sarenac, Olivera | |
dc.creator | Lozic-Đurić, Maja | |
dc.creator | Murphy, David | |
dc.creator | Japundžić-Žigon, Nina | |
dc.date.accessioned | 2020-07-02T12:46:47Z | |
dc.date.available | 2020-07-02T12:46:47Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0007-1188 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1834 | |
dc.description.abstract | Background and Purpose It is well recognized that vasopressin modulates the neurogenic control of the circulation. Here, we report the central mechanisms by which vasopressin modulates cardiovascular response to stress induced by immobilization. Experimental Approach Experiments were performed in conscious male Wistar rats equipped with radiotelemetric device for continuous measurement of haemodynamic parameters: systolic and diastolic BP and heart rate (HR). The functioning of the spontaneous baro-receptor reflex (BRR) was evaluated using the sequence method and the following parameters were evaluated: BRR sensitivity (BRS) and BRR effectiveness index (BEI). Key Results Under baseline physiological conditions intracerebroventricular injection of 100 and 500ng of selective non-peptide V1a or V1b or V2 receptor antagonist did not modify BP, HR and BRR. Rats exposed to 15min long stress by immobilization exhibited increase of BP, HR, reduction of BRS and no change in BEI. Pretreatment of rats with V1a receptor antagonist did not modulate the BP, HR, BRS and BEI response to stress. Pretreatment of rats with V1b receptor and V2 receptor antagonist, at both doses, prevented BRR desensitization and tachycardia, but failed to modulate stress-induced hypertension. Conclusions and Implications Vasopressin by the stimulation of central V1b- and V2-like receptors mediates stress-induced tachycardia and BRR desensitization. If these mechanisms are involved, BRR desensitization in heart failure and hypertension associated with poor outcome, they could be considered as novel targets for cardiovascular drug development. | en |
dc.publisher | Wiley-Blackwell, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41013/RS// | |
dc.relation | Physiological Society (UK) | |
dc.rights | openAccess | |
dc.source | British Journal of Pharmacology | |
dc.subject | V1a receptor antagonist | en |
dc.subject | V1b receptor antagonist | en |
dc.subject | V2 receptor antagonist | en |
dc.subject | stress | en |
dc.subject | baro-receptor reflex | en |
dc.title | Evidence for involvement of central vasopressin V1b and V2 receptors in stress-induced baroreflex desensitization | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Милутиновић-Смиљанић, Сања; Јапунджић-Жигон, Нина; Мурпхy, Давид; Саренац, Оливера; Лозиц-Ђурић, Маја; | |
dc.citation.volume | 169 | |
dc.citation.issue | 4 | |
dc.citation.spage | 900 | |
dc.citation.epage | 908 | |
dc.citation.other | 169(4): 900-908 | |
dc.citation.rank | aM21 | |
dc.identifier.wos | 000319477200016 | |
dc.identifier.doi | 10.1111/bph.12161 | |
dc.identifier.pmid | 23488898 | |
dc.identifier.scopus | 2-s2.0-84878292703 | |
dc.identifier.fulltext | https://smile.stomf.bg.ac.rs/bitstream/id/3339/1829.pdf | |
dc.type.version | publishedVersion |