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Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment
dc.creator | Janković, Saša | |
dc.creator | Aleksić, Zoran | |
dc.creator | Dimitrijević, Božidar | |
dc.creator | Camargo, Paulo | |
dc.creator | Kenney, Barrie | |
dc.creator | Leković, Vojislav | |
dc.date.accessioned | 2020-07-02T12:47:28Z | |
dc.date.available | 2020-07-02T12:47:28Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0198-7569 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1844 | |
dc.description.abstract | Risk factors such as smoking, genetic factors, and tissue biotype play an important role in the etiology, predictability, and long-term stability of gingival recession treatment. This study was designed to evaluate the influence of interleukin 1 (IL-1) polymorphism and smoking on the stability of gingival recession treatment after 1 and 3 years. All patients (n = 55) were treated for type I and II recession defects using a connective tissue graft. Clinical evaluations were performed, which included assessment of vertical recession depth, gingival inflammation, and clinical attachment level. A fingerstick blood sample was collected using specially provided DNA filter paper and mailed for processing in a laboratory using polymerase chain reaction-based methodology. The results indicated that 19 subjects were genotype positive (34.5%). Treatment of the localized recessions was effective and provided a similar amount of coverage in genotype-positive and genotype-negative subjects within smoking and nonsmoking groups after 1 year. In a 3-year period, nonsmoking patients with positive IL-1 genotype lost approximately 20% of the root coverage gained at 1 year and were almost four times more inferior compared with genotype-negative patients. Patients who smoked and had a positive IL-1 genotype lost approximately 35% of the gained root coverage. IL-1 polymorphism and smoking habit did not affect gingival recession treatment at 1 year but had a great impact on long-term stability. | en |
dc.publisher | Quintessence Publishing Co Inc, Hanover Park | |
dc.rights | restrictedAccess | |
dc.source | International Journal of Periodontics & Restorative Dentistry | |
dc.title | Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aлексић, Зоран; Лековић, Војислав; Јанковић, Саша; Кеннеy, Баррие; Цамарго, Пауло; Димитријевић, Божидар; | |
dc.citation.volume | 33 | |
dc.citation.issue | 1 | |
dc.citation.spage | E16 | |
dc.citation.epage | E23 | |
dc.citation.other | 33(1): E16-E23 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000320113400003 | |
dc.identifier.doi | 10.11607/prd.0823 | |
dc.identifier.pmid | 23342354 | |
dc.identifier.scopus | 2-s2.0-84891885921 | |
dc.type.version | publishedVersion |