Association of functional variants of phase i and ii genes with chronic obstructive pulmonary disease in a Serbian population
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2015
Authors
Stanković, MarijaNikolić, Aleksandra
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Tomović, Andrija
Mitic-Milikić, Marija
Nagorni-Obradović, Ljudmila
Petrović-Stanojević, Nataša
Radojković, Dragica
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Article (Published version)
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Background: Chronic obstructive pulmonary disease (COPD) is a complex disorder characterized by increased oxidative stress. Functional genetic variants of phase I and II genes are implicated in oxidants antioxidants imbalance and may be involved in COPD development. In this study, we aimed to investigate the role of cytochrome P450 (CYP), glutathione S-transferase (GST) and microsomal epoxide hydrolase (mEH) functional variants in the pathogenesis of COPD in a Serbian population. Methods: The genotypes of 122 COPD patients and 100 controls with normal lung function were determined for CYP1A1 *1A/*2A, CYP2E1 *1A/*5B, GSTM1 null, GSTT1 null GSTP1 11e105Val, mEH Tyr113His and mEH His139Arg gene variants. Results: Results obtained showed that GSTM1 null variant was significantly more represented in COPD patients than in controls (61.5% vs. 47.0%; OR=1.80; p=0.042). Also, a significant difference was observed for combinations of GSTM1 null and GSTP1 105Val/(Val) (38.5% vs. 24.0%; OR=1.98; p...=0.029), as well as for CYP1A1 *1A/*2A, GSTM1 null and mEH 113His/(His) genotypes (7.4% vs. 1.0%; OR=7.88; p=0.025). Conclusions: These are the first data concerning the analysis of the variants of phase I and II genes in the pathogenesis of COPD in a Serbian population. Results obtained in this study open up the possibility for thorough analyses of the role of genetic factors in COPD on larger cohorts. Also, they implicate the importance of previously described genetic associations with COPD in our population, as well as reveal a new one, not reported so far.
Keywords:
COPD / candidate gene association study / genetic variation / oxidative stressSource:
Journal of Medical Biochemistry, 2015, 34, 2, 207-214Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Funding / projects:
- Complex diseases as a model system for phenotype modulation- structural and functional analysis of molecular biomarkers (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.2478/jomb-2014-0024
ISSN: 1452-8258
PubMed: 28356833
WoS: 000348895300007
Scopus: 2-s2.0-84925619850
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Stomatološki fakultetTY - JOUR AU - Stanković, Marija AU - Nikolić, Aleksandra AU - Tomović, Andrija AU - Mitic-Milikić, Marija AU - Nagorni-Obradović, Ljudmila AU - Petrović-Stanojević, Nataša AU - Radojković, Dragica PY - 2015 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1960 AB - Background: Chronic obstructive pulmonary disease (COPD) is a complex disorder characterized by increased oxidative stress. Functional genetic variants of phase I and II genes are implicated in oxidants antioxidants imbalance and may be involved in COPD development. In this study, we aimed to investigate the role of cytochrome P450 (CYP), glutathione S-transferase (GST) and microsomal epoxide hydrolase (mEH) functional variants in the pathogenesis of COPD in a Serbian population. Methods: The genotypes of 122 COPD patients and 100 controls with normal lung function were determined for CYP1A1 *1A/*2A, CYP2E1 *1A/*5B, GSTM1 null, GSTT1 null GSTP1 11e105Val, mEH Tyr113His and mEH His139Arg gene variants. Results: Results obtained showed that GSTM1 null variant was significantly more represented in COPD patients than in controls (61.5% vs. 47.0%; OR=1.80; p=0.042). Also, a significant difference was observed for combinations of GSTM1 null and GSTP1 105Val/(Val) (38.5% vs. 24.0%; OR=1.98; p=0.029), as well as for CYP1A1 *1A/*2A, GSTM1 null and mEH 113His/(His) genotypes (7.4% vs. 1.0%; OR=7.88; p=0.025). Conclusions: These are the first data concerning the analysis of the variants of phase I and II genes in the pathogenesis of COPD in a Serbian population. Results obtained in this study open up the possibility for thorough analyses of the role of genetic factors in COPD on larger cohorts. Also, they implicate the importance of previously described genetic associations with COPD in our population, as well as reveal a new one, not reported so far. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Association of functional variants of phase i and ii genes with chronic obstructive pulmonary disease in a Serbian population VL - 34 IS - 2 SP - 207 EP - 214 DO - 10.2478/jomb-2014-0024 ER -
@article{ author = "Stanković, Marija and Nikolić, Aleksandra and Tomović, Andrija and Mitic-Milikić, Marija and Nagorni-Obradović, Ljudmila and Petrović-Stanojević, Nataša and Radojković, Dragica", year = "2015", abstract = "Background: Chronic obstructive pulmonary disease (COPD) is a complex disorder characterized by increased oxidative stress. Functional genetic variants of phase I and II genes are implicated in oxidants antioxidants imbalance and may be involved in COPD development. In this study, we aimed to investigate the role of cytochrome P450 (CYP), glutathione S-transferase (GST) and microsomal epoxide hydrolase (mEH) functional variants in the pathogenesis of COPD in a Serbian population. Methods: The genotypes of 122 COPD patients and 100 controls with normal lung function were determined for CYP1A1 *1A/*2A, CYP2E1 *1A/*5B, GSTM1 null, GSTT1 null GSTP1 11e105Val, mEH Tyr113His and mEH His139Arg gene variants. Results: Results obtained showed that GSTM1 null variant was significantly more represented in COPD patients than in controls (61.5% vs. 47.0%; OR=1.80; p=0.042). Also, a significant difference was observed for combinations of GSTM1 null and GSTP1 105Val/(Val) (38.5% vs. 24.0%; OR=1.98; p=0.029), as well as for CYP1A1 *1A/*2A, GSTM1 null and mEH 113His/(His) genotypes (7.4% vs. 1.0%; OR=7.88; p=0.025). Conclusions: These are the first data concerning the analysis of the variants of phase I and II genes in the pathogenesis of COPD in a Serbian population. Results obtained in this study open up the possibility for thorough analyses of the role of genetic factors in COPD on larger cohorts. Also, they implicate the importance of previously described genetic associations with COPD in our population, as well as reveal a new one, not reported so far.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Association of functional variants of phase i and ii genes with chronic obstructive pulmonary disease in a Serbian population", volume = "34", number = "2", pages = "207-214", doi = "10.2478/jomb-2014-0024" }
Stanković, M., Nikolić, A., Tomović, A., Mitic-Milikić, M., Nagorni-Obradović, L., Petrović-Stanojević, N.,& Radojković, D.. (2015). Association of functional variants of phase i and ii genes with chronic obstructive pulmonary disease in a Serbian population. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(2), 207-214. https://doi.org/10.2478/jomb-2014-0024
Stanković M, Nikolić A, Tomović A, Mitic-Milikić M, Nagorni-Obradović L, Petrović-Stanojević N, Radojković D. Association of functional variants of phase i and ii genes with chronic obstructive pulmonary disease in a Serbian population. in Journal of Medical Biochemistry. 2015;34(2):207-214. doi:10.2478/jomb-2014-0024 .
Stanković, Marija, Nikolić, Aleksandra, Tomović, Andrija, Mitic-Milikić, Marija, Nagorni-Obradović, Ljudmila, Petrović-Stanojević, Nataša, Radojković, Dragica, "Association of functional variants of phase i and ii genes with chronic obstructive pulmonary disease in a Serbian population" in Journal of Medical Biochemistry, 34, no. 2 (2015):207-214, https://doi.org/10.2478/jomb-2014-0024 . .