Responses of the human submandibular artery to ACh and VIP
Нема приказа
Аутори
Pešić, SrđanRadenković, Miroslav
Popović-Roganović, Jelena
Pešić, Zoran
Grbović, Leosava
Stojić, Dragica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Endothelial vasodilatory substances may play a central role in the local regulation of vascular tone. We hypothesized that these substances can mediate endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery. We evaluated the contributions of endothelial vasodilatory substances to vessel relaxation in response to ACh and VIP, using different inhibitors of endothelial vasodilation, the nitric oxide synthase inhibitor, the cyclo-oxygenase inhibitor, indomethacin, the potassium channel blocker, and 4-aminopyridine. ACh and VIP caused an endothelium- and concentration-dependent relaxation in this artery. ACh relaxation was completely blocked after the concomitant addition of N(G)-nitro-L-arginine and indomethacin. The vasorelaxant effect of ACh was not influenced by 4-aminopyridine. VIP relaxation was almost completely abolished by 4-aminopyridine, and was partly inhibited by N(G)-nitro-L-arginine, but wa...s not affected by indomethacin. Thus, in the human submandibular artery, ACh and VIP produced endothelium-dependent vasodilation with different underlying mechanisms: release of nitric oxide (NO) and cyclo-oxygenase products for ACh, and release of NO and endothelium-derived hyperpolarizing factor for VIP.
Кључне речи:
ACh / VIP / human submandibular arteryИзвор:
Journal of Dental Research, 2007, 86, 6, 565-570Издавач:
- Sage Publications Inc.
DOI: 10.1177/154405910708600615
ISSN: 0022-0345
PubMed: 17525359
WoS: 000246726600015
Scopus: 2-s2.0-34347239616
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Pešić, Srđan AU - Radenković, Miroslav AU - Popović-Roganović, Jelena AU - Pešić, Zoran AU - Grbović, Leosava AU - Stojić, Dragica PY - 2007 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2589 AB - Endothelial vasodilatory substances may play a central role in the local regulation of vascular tone. We hypothesized that these substances can mediate endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery. We evaluated the contributions of endothelial vasodilatory substances to vessel relaxation in response to ACh and VIP, using different inhibitors of endothelial vasodilation, the nitric oxide synthase inhibitor, the cyclo-oxygenase inhibitor, indomethacin, the potassium channel blocker, and 4-aminopyridine. ACh and VIP caused an endothelium- and concentration-dependent relaxation in this artery. ACh relaxation was completely blocked after the concomitant addition of N(G)-nitro-L-arginine and indomethacin. The vasorelaxant effect of ACh was not influenced by 4-aminopyridine. VIP relaxation was almost completely abolished by 4-aminopyridine, and was partly inhibited by N(G)-nitro-L-arginine, but was not affected by indomethacin. Thus, in the human submandibular artery, ACh and VIP produced endothelium-dependent vasodilation with different underlying mechanisms: release of nitric oxide (NO) and cyclo-oxygenase products for ACh, and release of NO and endothelium-derived hyperpolarizing factor for VIP. PB - Sage Publications Inc. T2 - Journal of Dental Research T1 - Responses of the human submandibular artery to ACh and VIP VL - 86 IS - 6 SP - 565 EP - 570 DO - 10.1177/154405910708600615 ER -
@article{ author = "Pešić, Srđan and Radenković, Miroslav and Popović-Roganović, Jelena and Pešić, Zoran and Grbović, Leosava and Stojić, Dragica", year = "2007", abstract = "Endothelial vasodilatory substances may play a central role in the local regulation of vascular tone. We hypothesized that these substances can mediate endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery. We evaluated the contributions of endothelial vasodilatory substances to vessel relaxation in response to ACh and VIP, using different inhibitors of endothelial vasodilation, the nitric oxide synthase inhibitor, the cyclo-oxygenase inhibitor, indomethacin, the potassium channel blocker, and 4-aminopyridine. ACh and VIP caused an endothelium- and concentration-dependent relaxation in this artery. ACh relaxation was completely blocked after the concomitant addition of N(G)-nitro-L-arginine and indomethacin. The vasorelaxant effect of ACh was not influenced by 4-aminopyridine. VIP relaxation was almost completely abolished by 4-aminopyridine, and was partly inhibited by N(G)-nitro-L-arginine, but was not affected by indomethacin. Thus, in the human submandibular artery, ACh and VIP produced endothelium-dependent vasodilation with different underlying mechanisms: release of nitric oxide (NO) and cyclo-oxygenase products for ACh, and release of NO and endothelium-derived hyperpolarizing factor for VIP.", publisher = "Sage Publications Inc.", journal = "Journal of Dental Research", title = "Responses of the human submandibular artery to ACh and VIP", volume = "86", number = "6", pages = "565-570", doi = "10.1177/154405910708600615" }
Pešić, S., Radenković, M., Popović-Roganović, J., Pešić, Z., Grbović, L.,& Stojić, D.. (2007). Responses of the human submandibular artery to ACh and VIP. in Journal of Dental Research Sage Publications Inc.., 86(6), 565-570. https://doi.org/10.1177/154405910708600615
Pešić S, Radenković M, Popović-Roganović J, Pešić Z, Grbović L, Stojić D. Responses of the human submandibular artery to ACh and VIP. in Journal of Dental Research. 2007;86(6):565-570. doi:10.1177/154405910708600615 .
Pešić, Srđan, Radenković, Miroslav, Popović-Roganović, Jelena, Pešić, Zoran, Grbović, Leosava, Stojić, Dragica, "Responses of the human submandibular artery to ACh and VIP" in Journal of Dental Research, 86, no. 6 (2007):565-570, https://doi.org/10.1177/154405910708600615 . .