TY  - JOUR
AU  - Ayoub, Giuma
AU  - Ležaja-Zebić, Maja
AU  - Miletić, Vesna
AU  - Petrović, Rada
AU  - Veljović, Đorđe
AU  - Janaćković, Đorđe
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1046
AB  - The application of sintered calcium phosphate dental inserts in the central part of tooth cavities can reduce amount of embedded dental composite and polymerization shrinkage of final dental fillings. The aim of this study was to analyze comparatively physico-chemical and mechanical properties of dental inserts and shear bond strength (SBS) between three dissimilar hydroxyapatite-based dental inserts and different restorative materials, after application of different clinical protocols. Starting from two different hydroxyapatite nano powders and nanostructured stabilized zirconia (YSZ), monophasic two-step sintered dense HAp inserts (TSSHAp), biphasic single-step sintered controlled porous inserts (HAp/TCp), and single-step sintered reinforced HAp/YSZ inserts were processed and characterized. Obvious differences in the microstructure of inserts surface were visualized after etching with 37% phosphoric acid. Fracture toughness of sintered inserts was ranged between 1.01 and 1.85 MPam(1/2) (maximum value in the case of HAp/YSZ), while hardness values were in the range of 3.71-5.22 GPa (maximum value in the case of TSSHAp). Acid etching before application improved SBS between inserts and Maxcem compared to direct cement application. TSSHAp and HAP/TCp inserts showed comparable and relatively high SBS values, certainly higher compared to HAp/YSZ inserts. Slightly higher SBS values were measured in the case of TSSHAp insert group, and the highest mean SBS value of 18.51 MPa was determined between TSSHAp inserts and Filtek Z250_SBU following the "self-etch" protocol.
PB  - Wiley, Hoboken
T2  - Journal of Biomedical Materials Research Part B: Applied Biomaterials
T1  - Dissimilar sintered calcium phosphate dental inserts as dentine substitutes: Shear bond strength to restorative materials
DO  - 10.1002/jbm.b.34578
ER  - 

@article{
author = "Ayoub, Giuma and Ležaja-Zebić, Maja and Miletić, Vesna and Petrović, Rada and Veljović, Đorđe and Janaćković, Đorđe",
year = "2020",
abstract = "The application of sintered calcium phosphate dental inserts in the central part of tooth cavities can reduce amount of embedded dental composite and polymerization shrinkage of final dental fillings. The aim of this study was to analyze comparatively physico-chemical and mechanical properties of dental inserts and shear bond strength (SBS) between three dissimilar hydroxyapatite-based dental inserts and different restorative materials, after application of different clinical protocols. Starting from two different hydroxyapatite nano powders and nanostructured stabilized zirconia (YSZ), monophasic two-step sintered dense HAp inserts (TSSHAp), biphasic single-step sintered controlled porous inserts (HAp/TCp), and single-step sintered reinforced HAp/YSZ inserts were processed and characterized. Obvious differences in the microstructure of inserts surface were visualized after etching with 37% phosphoric acid. Fracture toughness of sintered inserts was ranged between 1.01 and 1.85 MPam(1/2) (maximum value in the case of HAp/YSZ), while hardness values were in the range of 3.71-5.22 GPa (maximum value in the case of TSSHAp). Acid etching before application improved SBS between inserts and Maxcem compared to direct cement application. TSSHAp and HAP/TCp inserts showed comparable and relatively high SBS values, certainly higher compared to HAp/YSZ inserts. Slightly higher SBS values were measured in the case of TSSHAp insert group, and the highest mean SBS value of 18.51 MPa was determined between TSSHAp inserts and Filtek Z250_SBU following the "self-etch" protocol.",
publisher = "Wiley, Hoboken",
journal = "Journal of Biomedical Materials Research Part B: Applied Biomaterials",
title = "Dissimilar sintered calcium phosphate dental inserts as dentine substitutes: Shear bond strength to restorative materials",
doi = "10.1002/jbm.b.34578"
}

Ayoub, G., Ležaja-Zebić, M., Miletić, V., Petrović, R., Veljović, Đ.,& Janaćković, Đ.. (2020). Dissimilar sintered calcium phosphate dental inserts as dentine substitutes: Shear bond strength to restorative materials. in Journal of Biomedical Materials Research Part B: Applied Biomaterials
Wiley, Hoboken..
https://doi.org/10.1002/jbm.b.34578

Ayoub G, Ležaja-Zebić M, Miletić V, Petrović R, Veljović Đ, Janaćković Đ. Dissimilar sintered calcium phosphate dental inserts as dentine substitutes: Shear bond strength to restorative materials. in Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2020;.
doi:10.1002/jbm.b.34578 .

Ayoub, Giuma, Ležaja-Zebić, Maja, Miletić, Vesna, Petrović, Rada, Veljović, Đorđe, Janaćković, Đorđe, "Dissimilar sintered calcium phosphate dental inserts as dentine substitutes: Shear bond strength to restorative materials" in Journal of Biomedical Materials Research Part B: Applied Biomaterials (2020),
https://doi.org/10.1002/jbm.b.34578 . .

TY  - JOUR
AU  - Ayoub, Giuma
AU  - Veljović, Đorđe
AU  - Ležaja-Zebić, Maja
AU  - Miletić, Vesna
AU  - Palcevskis, Eriks
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2305
AB  - The objective of the study was to process nano-structured hydroxyapatite/yttrium-stabilized zirconia bioceramic and to investigate the possibilities of its application as dentin replacement in the form of dental inserts. The processing conditions were varied in order to optimize phase composition, microstructure, fracture toughness, hardness and shear bond strength (SBS) between the obtained composite inserts and restorative materials, following either the "total-etch" or "self-etch" clinical protocol. Composite nano-powder, obtained by mixing and homogenization of 80 wt% of stoichiometric hydroxyapatite (HAp) synthesized by modified precipitation method and 20wt% of yttrium-stabilized ZrO2 (YSZ) synthesized by plasma method, was isostatically pressed into cylinder-shaped green bodies. After dilatometric analysis, HAp/YSZ inserts were sintered in the temperature range from 1200 degrees C to 1300 degrees C. Hardness and fracture toughness of sintered inserts were ranged between 3.90 +/- 0.20 - 3.95 +/- 0.12 GPa and 1.82 +/- 0.04 - 1.88 +/- 0.03 MPam(1/2), respectively. Microstructural analysis of biphasic HAp/t-ZrO2 inserts indicated two potential fracture mechanisms for fracture toughness increasing. Sintering temperature and different clinical protocols affected SBS between processed inserts and commercial dental restorative materials. Maximum SBS values of 10.50 +/- 4.94 MPa (mean standard deviation) were reached in inserts sintered at 1300 degrees C, following the "self-etch" protocol of adhesive application. It could be concluded that resin-based composites could be strongly bonded to HAp/YSZ inserts, preferably with self-etch" adhesive application. In addition, the values of fracture toughness and hardness of the obtained inserts indicated the possibility of their usage as dentin substitutes, which could be a good prerequisite for satisfactory mechanics of restored teeth.
PB  - Elsevier Sci Ltd, Oxford
T2  - Ceramics International
T1  - Composite nanostructured hydroxyapatite/yttrium stabilized zirconia dental inserts - The processing and application as dentin substitutes
VL  - 44
IS  - 15
SP  - 18200
EP  - 18208
DO  - 10.1016/j.ceramint.2018.07.028
ER  - 

@article{
author = "Ayoub, Giuma and Veljović, Đorđe and Ležaja-Zebić, Maja and Miletić, Vesna and Palcevskis, Eriks and Petrović, Rada and Janaćković, Đorđe",
year = "2018",
abstract = "The objective of the study was to process nano-structured hydroxyapatite/yttrium-stabilized zirconia bioceramic and to investigate the possibilities of its application as dentin replacement in the form of dental inserts. The processing conditions were varied in order to optimize phase composition, microstructure, fracture toughness, hardness and shear bond strength (SBS) between the obtained composite inserts and restorative materials, following either the "total-etch" or "self-etch" clinical protocol. Composite nano-powder, obtained by mixing and homogenization of 80 wt% of stoichiometric hydroxyapatite (HAp) synthesized by modified precipitation method and 20wt% of yttrium-stabilized ZrO2 (YSZ) synthesized by plasma method, was isostatically pressed into cylinder-shaped green bodies. After dilatometric analysis, HAp/YSZ inserts were sintered in the temperature range from 1200 degrees C to 1300 degrees C. Hardness and fracture toughness of sintered inserts were ranged between 3.90 +/- 0.20 - 3.95 +/- 0.12 GPa and 1.82 +/- 0.04 - 1.88 +/- 0.03 MPam(1/2), respectively. Microstructural analysis of biphasic HAp/t-ZrO2 inserts indicated two potential fracture mechanisms for fracture toughness increasing. Sintering temperature and different clinical protocols affected SBS between processed inserts and commercial dental restorative materials. Maximum SBS values of 10.50 +/- 4.94 MPa (mean standard deviation) were reached in inserts sintered at 1300 degrees C, following the "self-etch" protocol of adhesive application. It could be concluded that resin-based composites could be strongly bonded to HAp/YSZ inserts, preferably with self-etch" adhesive application. In addition, the values of fracture toughness and hardness of the obtained inserts indicated the possibility of their usage as dentin substitutes, which could be a good prerequisite for satisfactory mechanics of restored teeth.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Ceramics International",
title = "Composite nanostructured hydroxyapatite/yttrium stabilized zirconia dental inserts - The processing and application as dentin substitutes",
volume = "44",
number = "15",
pages = "18200-18208",
doi = "10.1016/j.ceramint.2018.07.028"
}

Ayoub, G., Veljović, Đ., Ležaja-Zebić, M., Miletić, V., Palcevskis, E., Petrović, R.,& Janaćković, Đ.. (2018). Composite nanostructured hydroxyapatite/yttrium stabilized zirconia dental inserts - The processing and application as dentin substitutes. in Ceramics International
Elsevier Sci Ltd, Oxford., 44(15), 18200-18208.
https://doi.org/10.1016/j.ceramint.2018.07.028

Ayoub G, Veljović Đ, Ležaja-Zebić M, Miletić V, Palcevskis E, Petrović R, Janaćković Đ. Composite nanostructured hydroxyapatite/yttrium stabilized zirconia dental inserts - The processing and application as dentin substitutes. in Ceramics International. 2018;44(15):18200-18208.
doi:10.1016/j.ceramint.2018.07.028 .

Ayoub, Giuma, Veljović, Đorđe, Ležaja-Zebić, Maja, Miletić, Vesna, Palcevskis, Eriks, Petrović, Rada, Janaćković, Đorđe, "Composite nanostructured hydroxyapatite/yttrium stabilized zirconia dental inserts - The processing and application as dentin substitutes" in Ceramics International, 44, no. 15 (2018):18200-18208,
https://doi.org/10.1016/j.ceramint.2018.07.028 . .

TY  - JOUR
AU  - Matić, Tamara
AU  - Ležaja-Zebić, Maja
AU  - Cvijović-Alagić, Ivana
AU  - Miletić, Vesna
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
AU  - Veljović, Đorđe
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2281
AB  - This study aimed to investigate the possibility of modifying model BisGMA/TEGDMA dental composite by substituting 10 wt. % of conventional glass fillers with bioactive fillers based on calcinated nanosized hydroxyapatite (HAp) and Mg-doped hydroxyapatite (Mg-HAp). HAp and Mg-HAp powders were synthesized hydrothermally. Mechanical properties: hardness by Vickers (HV) and flexural strength (Fs) were tested initially and after being stored for 28 days in simulated body fluid (SBF). The experimental composites with HAp and Mg-HAp particles showed no statistically significant difference in HV compared to the control (p>0.05) either initially or after storage. Although mean Fs values of modified composites tested initially were lower (62 MPa) than those of the control (72 MPa), after 28 days of storage in SBF Fs values were greater for modified composites (42 MPa control sample, 48 MPa HAp, and Mg-HAp samples). In vitro bioactivity of BisGMA/TEGDMA composites with HAp and Mg-HAp particles after 28 days in SBF was not detected.
PB  - Savez inženjera metalurgije Srbije, Beograd
T2  - Metallurgical & Materials Engineering
T1  - The effect of calcinated hydroxyapatite and magnesium doped hydroxyapatite as fillers on the mechanical properties of a model bisgma/tegdma dental composite initially and after aging
VL  - 24
IS  - 4
SP  - 271
EP  - 281
DO  - 10.30544/403
ER  - 

@article{
author = "Matić, Tamara and Ležaja-Zebić, Maja and Cvijović-Alagić, Ivana and Miletić, Vesna and Petrović, Rada and Janaćković, Đorđe and Veljović, Đorđe",
year = "2018",
abstract = "This study aimed to investigate the possibility of modifying model BisGMA/TEGDMA dental composite by substituting 10 wt. % of conventional glass fillers with bioactive fillers based on calcinated nanosized hydroxyapatite (HAp) and Mg-doped hydroxyapatite (Mg-HAp). HAp and Mg-HAp powders were synthesized hydrothermally. Mechanical properties: hardness by Vickers (HV) and flexural strength (Fs) were tested initially and after being stored for 28 days in simulated body fluid (SBF). The experimental composites with HAp and Mg-HAp particles showed no statistically significant difference in HV compared to the control (p>0.05) either initially or after storage. Although mean Fs values of modified composites tested initially were lower (62 MPa) than those of the control (72 MPa), after 28 days of storage in SBF Fs values were greater for modified composites (42 MPa control sample, 48 MPa HAp, and Mg-HAp samples). In vitro bioactivity of BisGMA/TEGDMA composites with HAp and Mg-HAp particles after 28 days in SBF was not detected.",
publisher = "Savez inženjera metalurgije Srbije, Beograd",
journal = "Metallurgical & Materials Engineering",
title = "The effect of calcinated hydroxyapatite and magnesium doped hydroxyapatite as fillers on the mechanical properties of a model bisgma/tegdma dental composite initially and after aging",
volume = "24",
number = "4",
pages = "271-281",
doi = "10.30544/403"
}

Matić, T., Ležaja-Zebić, M., Cvijović-Alagić, I., Miletić, V., Petrović, R., Janaćković, Đ.,& Veljović, Đ.. (2018). The effect of calcinated hydroxyapatite and magnesium doped hydroxyapatite as fillers on the mechanical properties of a model bisgma/tegdma dental composite initially and after aging. in Metallurgical & Materials Engineering
Savez inženjera metalurgije Srbije, Beograd., 24(4), 271-281.
https://doi.org/10.30544/403

Matić T, Ležaja-Zebić M, Cvijović-Alagić I, Miletić V, Petrović R, Janaćković Đ, Veljović Đ. The effect of calcinated hydroxyapatite and magnesium doped hydroxyapatite as fillers on the mechanical properties of a model bisgma/tegdma dental composite initially and after aging. in Metallurgical & Materials Engineering. 2018;24(4):271-281.
doi:10.30544/403 .

Matić, Tamara, Ležaja-Zebić, Maja, Cvijović-Alagić, Ivana, Miletić, Vesna, Petrović, Rada, Janaćković, Đorđe, Veljović, Đorđe, "The effect of calcinated hydroxyapatite and magnesium doped hydroxyapatite as fillers on the mechanical properties of a model bisgma/tegdma dental composite initially and after aging" in Metallurgical & Materials Engineering, 24, no. 4 (2018):271-281,
https://doi.org/10.30544/403 . .

TY  - JOUR
AU  - Ležaja, Maja
AU  - Veljović, Đorđe
AU  - Manojlović, Dragica
AU  - Milošević, Miloš
AU  - Mitrović, Nenad
AU  - Janaćković, Đorđe
AU  - Miletić, Vesna
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1962
AB  - Objective. To determine the shear bond strength (SBS) between synthetic controlled porous hydroxyapatite (HAP) inserts and restorative materials and dimensional changes of insert-containing restorations during curing. Methods. Cylinder-shaped HAP inserts (4 mm in diameter, 1.6 mm thick) were cemented in dentin discs (5 mm x 1.6 mm), cut mid-coronally from human third molars, using one of the following materials: universal microhybrid composite Filtek Z250, flowable composite Filtek Ultimate or glass-ionomer Vitrebond (all 3M ESPE). SBS of the same materials to HAP inserts was tested in a universal testing machine. Three-dimensional digital image correlation system Aramis (GOM) was used to measure strains and displacements. Data were statistically analyzed using one-way ANOVA with Tukey's post-test (alpha = 0.05). Results. SBS of restorative materials to HAP inserts ranged between 12.2 +/- 2.1 MPa (Filtek Z250) and 0.7 +/- 0.4 MPa (Filtek Z250 without an adhesive). The 'total-etch' approach of adhesive application significantly increased SBS of both Filtek Z250 (12.2 +/- 2.1 MPa) and Filtek Ultimate flowable (9.5 +/- 2.5 MPa) compared to the 'self-etch' approach (8.2 +/- 1.6 MPa and 4.4 +/- 0.9 MPa, respectively) (p  lt  0.05). HAP inserts reduced polymerization shrinkage to below 0.5% as well as displacements in the central region of the restorations. Peripheral shrinkage of restorative materials was similar with and without HAP inserts as were displacements of Filtek Z250 and Vitrebond. Significance. Replacing major part of dentin clinically, especially in large cavities, HAP inserts may shorten clinical working time, improve dimensional stability of the restoration by reducing central shrinkage and displacements and provide adhesive bonding to universal composites following a 'total-etch' approach.
PB  - Elsevier Sci Ltd, Oxford
T2  - Dental Materials
T1  - Bond strength of restorative materials to hydroxyapatite inserts and dimensional changes of insert-containing restorations during polymerization
VL  - 31
IS  - 2
SP  - 171
EP  - 181
DO  - 10.1016/j.dental.2014.11.017
ER  - 

@article{
author = "Ležaja, Maja and Veljović, Đorđe and Manojlović, Dragica and Milošević, Miloš and Mitrović, Nenad and Janaćković, Đorđe and Miletić, Vesna",
year = "2015",
abstract = "Objective. To determine the shear bond strength (SBS) between synthetic controlled porous hydroxyapatite (HAP) inserts and restorative materials and dimensional changes of insert-containing restorations during curing. Methods. Cylinder-shaped HAP inserts (4 mm in diameter, 1.6 mm thick) were cemented in dentin discs (5 mm x 1.6 mm), cut mid-coronally from human third molars, using one of the following materials: universal microhybrid composite Filtek Z250, flowable composite Filtek Ultimate or glass-ionomer Vitrebond (all 3M ESPE). SBS of the same materials to HAP inserts was tested in a universal testing machine. Three-dimensional digital image correlation system Aramis (GOM) was used to measure strains and displacements. Data were statistically analyzed using one-way ANOVA with Tukey's post-test (alpha = 0.05). Results. SBS of restorative materials to HAP inserts ranged between 12.2 +/- 2.1 MPa (Filtek Z250) and 0.7 +/- 0.4 MPa (Filtek Z250 without an adhesive). The 'total-etch' approach of adhesive application significantly increased SBS of both Filtek Z250 (12.2 +/- 2.1 MPa) and Filtek Ultimate flowable (9.5 +/- 2.5 MPa) compared to the 'self-etch' approach (8.2 +/- 1.6 MPa and 4.4 +/- 0.9 MPa, respectively) (p  lt  0.05). HAP inserts reduced polymerization shrinkage to below 0.5% as well as displacements in the central region of the restorations. Peripheral shrinkage of restorative materials was similar with and without HAP inserts as were displacements of Filtek Z250 and Vitrebond. Significance. Replacing major part of dentin clinically, especially in large cavities, HAP inserts may shorten clinical working time, improve dimensional stability of the restoration by reducing central shrinkage and displacements and provide adhesive bonding to universal composites following a 'total-etch' approach.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Dental Materials",
title = "Bond strength of restorative materials to hydroxyapatite inserts and dimensional changes of insert-containing restorations during polymerization",
volume = "31",
number = "2",
pages = "171-181",
doi = "10.1016/j.dental.2014.11.017"
}

Ležaja, M., Veljović, Đ., Manojlović, D., Milošević, M., Mitrović, N., Janaćković, Đ.,& Miletić, V.. (2015). Bond strength of restorative materials to hydroxyapatite inserts and dimensional changes of insert-containing restorations during polymerization. in Dental Materials
Elsevier Sci Ltd, Oxford., 31(2), 171-181.
https://doi.org/10.1016/j.dental.2014.11.017

Ležaja M, Veljović Đ, Manojlović D, Milošević M, Mitrović N, Janaćković Đ, Miletić V. Bond strength of restorative materials to hydroxyapatite inserts and dimensional changes of insert-containing restorations during polymerization. in Dental Materials. 2015;31(2):171-181.
doi:10.1016/j.dental.2014.11.017 .

Ležaja, Maja, Veljović, Đorđe, Manojlović, Dragica, Milošević, Miloš, Mitrović, Nenad, Janaćković, Đorđe, Miletić, Vesna, "Bond strength of restorative materials to hydroxyapatite inserts and dimensional changes of insert-containing restorations during polymerization" in Dental Materials, 31, no. 2 (2015):171-181,
https://doi.org/10.1016/j.dental.2014.11.017 . .

TY  - JOUR
AU  - Jokić, Bojan
AU  - Stamenković, Ivan
AU  - Zrilić, Milorad
AU  - Obradović-Đuričić, Kosovka
AU  - Petrović, Rada
AU  - Janaćković, Đorđe
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1757
AB  - In this study, spherical particles of hydroxyapatite (HA) and alpha-tricalcium phosphate (alpha-Ca-3(PO4)(2): alpha-TCP) doped with different amounts of silicon were used for the preparation of scaffolds. The scaffolds were obtained by a replica foam method using particles of narrow size distribution pre-annealed at 1150 degrees C with different alpha-TCP and HA contents in order to investigate the effect of composition on their morphological and mechanical properties. Morphology, size, and distribution of the particles were characterized using scanning electron microscopy and particle size analyzer. The obtained alpha-TCP-HA scaffolds had compressive strengths up to 5.7 MPa with a uniform and interconnected porous structure. X-ray diffraction analysis used to determine the crystal structure of the scaffolds confirmed that the alpha-TCP-HA content could be controlled by the amount of silicon ions.
PB  - Elsevier Science Bv, Amsterdam
T2  - Materials Letters
T1  - Silicon-doped biphasic alpha-calcium-phosphate/hydroxyapatite scaffolds obtained by a replica foam method using uniform pre-annealed spherical particles
VL  - 74
SP  - 155
EP  - 158
DO  - 10.1016/j.matlet.2012.01.081
ER  - 

@article{
author = "Jokić, Bojan and Stamenković, Ivan and Zrilić, Milorad and Obradović-Đuričić, Kosovka and Petrović, Rada and Janaćković, Đorđe",
year = "2012",
abstract = "In this study, spherical particles of hydroxyapatite (HA) and alpha-tricalcium phosphate (alpha-Ca-3(PO4)(2): alpha-TCP) doped with different amounts of silicon were used for the preparation of scaffolds. The scaffolds were obtained by a replica foam method using particles of narrow size distribution pre-annealed at 1150 degrees C with different alpha-TCP and HA contents in order to investigate the effect of composition on their morphological and mechanical properties. Morphology, size, and distribution of the particles were characterized using scanning electron microscopy and particle size analyzer. The obtained alpha-TCP-HA scaffolds had compressive strengths up to 5.7 MPa with a uniform and interconnected porous structure. X-ray diffraction analysis used to determine the crystal structure of the scaffolds confirmed that the alpha-TCP-HA content could be controlled by the amount of silicon ions.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Materials Letters",
title = "Silicon-doped biphasic alpha-calcium-phosphate/hydroxyapatite scaffolds obtained by a replica foam method using uniform pre-annealed spherical particles",
volume = "74",
pages = "155-158",
doi = "10.1016/j.matlet.2012.01.081"
}

Jokić, B., Stamenković, I., Zrilić, M., Obradović-Đuričić, K., Petrović, R.,& Janaćković, Đ.. (2012). Silicon-doped biphasic alpha-calcium-phosphate/hydroxyapatite scaffolds obtained by a replica foam method using uniform pre-annealed spherical particles. in Materials Letters
Elsevier Science Bv, Amsterdam., 74, 155-158.
https://doi.org/10.1016/j.matlet.2012.01.081

Jokić B, Stamenković I, Zrilić M, Obradović-Đuričić K, Petrović R, Janaćković Đ. Silicon-doped biphasic alpha-calcium-phosphate/hydroxyapatite scaffolds obtained by a replica foam method using uniform pre-annealed spherical particles. in Materials Letters. 2012;74:155-158.
doi:10.1016/j.matlet.2012.01.081 .

Jokić, Bojan, Stamenković, Ivan, Zrilić, Milorad, Obradović-Đuričić, Kosovka, Petrović, Rada, Janaćković, Đorđe, "Silicon-doped biphasic alpha-calcium-phosphate/hydroxyapatite scaffolds obtained by a replica foam method using uniform pre-annealed spherical particles" in Materials Letters, 74 (2012):155-158,
https://doi.org/10.1016/j.matlet.2012.01.081 . .

TY  - JOUR
AU  - Marković, Danica
AU  - Kojić, Zvezdana
AU  - Marinković, D.
AU  - Danilović, Vesna
AU  - Radovanović, Anita
AU  - Janaćković, Đorđe
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1473
AB  - The purpose of this study was to evaluate the tissue response induced by bioceramical materials (BCM) implanted in rat subcutaneous tissue. Thirty two rats were assigned to 6 groups, as following: control group i.e. not treated; dental ceramic (DC) implants; alfa tricalcium phosphate synthetised at 22 MPa (αTCP22) and at 45 MPa (αTCP45); hydroxyapatite synthetised at 22 MPa (HAP22) and at 45 MPa (HAP45). Contra lateral sides of all test animals represented the blank control surgically incisied at the paravertebral sockets. The experimental groups received subcutaneous implants of the test BCM materials. Samples were collected after 14 days and processed histologically. Inflammatory reactions were noted microscopically. The inflammatory infiltrate consisted of lymphocytes, polimorphonuclears, macrophages and mastocytes. At same time there were signs of increased fibrosis around the graft places. In conclusion, the implant sides compared with surgical incision wounds induced a foreign body-type granuloma with subsequent fibrosis around the grafts. The presence of a capsule at the interface with BCM in rat subcutis did not elicit any remarkable immune responses, thus being considered biocompatible. By evaluating different responses according to BCM, the most intense tissue reaction was noticed at HAP45, graded as severe, and mild to moderate for DC, HAP22 and alfa tricaltium phosphate.
AB  - Svrha ove studije je bila procena tkivnog odgovora indukovanog biokeramič kim materijalima (BCM) inplantiranim u subkutano tkivo pacova. Trideset dva pacova je bilo podeljeno u sledećih 6 grupa: kontrolna grupa-neoperisana; inplantirane sa: dentalnom keramikom (DC); alfa trikalcijum fosfatima sintetisanim na 22 MPa (αTCP22) i na 45 MPa (αTCP45); hidroksiapatitom sintetisanim na 22 MPa (HAP22) i na 45 MPa (HAP45). Kontralateralne strane svih životinja bile su slepa kontrola i urađene su kao džepovi hirurške incizije u subkutanom tkivu. Eksperimentalne grupe su imale subkutano inplantirane biokeramičke materijale. Uzorci su sakupljeni posle 14 dana i sprovedeni u histološkoj proceduri, a inflamatorna reakcija je praćena mikroskopski. Inflamatorni infiltrat se sastojao od limfocita, polimorfonuklearnih leukocita, makrofaga i mastocita. Istovremeno su uočeni znaci rastuće fibroze oko mesta graftova. Inplantirana mesta u poređenju sa hirurškim ranama indukuju granulom karakterističnog tipa na strano telo sa posledičnom fibrozom oko graftova, kapsulom na dodirnoj površini sa BCM u subkutisu pacova, ne izazivajući uočljivu imunološ ku reakciju, tako da odgovor tkiva ukazuje na biokompatibilnost. Procenjivanjem odgovora sa različitim BCM, zabeležena je najintenzivnija (snažna) tkivna reakcija kod HAP45 inplanta, a blaga do umerena kod DC, HAP22 i alfa trikalcijumfosfata.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Histological and immunohistochemical evaluations of rat soft tissue response to bioceramical implants
T1  - Histološka i imunohistohemijska procena reakcije mekog tkiva pacova na biokeramičke implante
VL  - 59
IS  - 2-3
SP  - 243
EP  - 253
DO  - 10.2298/AVB0903243M
ER  - 

@article{
author = "Marković, Danica and Kojić, Zvezdana and Marinković, D. and Danilović, Vesna and Radovanović, Anita and Janaćković, Đorđe",
year = "2009",
abstract = "The purpose of this study was to evaluate the tissue response induced by bioceramical materials (BCM) implanted in rat subcutaneous tissue. Thirty two rats were assigned to 6 groups, as following: control group i.e. not treated; dental ceramic (DC) implants; alfa tricalcium phosphate synthetised at 22 MPa (αTCP22) and at 45 MPa (αTCP45); hydroxyapatite synthetised at 22 MPa (HAP22) and at 45 MPa (HAP45). Contra lateral sides of all test animals represented the blank control surgically incisied at the paravertebral sockets. The experimental groups received subcutaneous implants of the test BCM materials. Samples were collected after 14 days and processed histologically. Inflammatory reactions were noted microscopically. The inflammatory infiltrate consisted of lymphocytes, polimorphonuclears, macrophages and mastocytes. At same time there were signs of increased fibrosis around the graft places. In conclusion, the implant sides compared with surgical incision wounds induced a foreign body-type granuloma with subsequent fibrosis around the grafts. The presence of a capsule at the interface with BCM in rat subcutis did not elicit any remarkable immune responses, thus being considered biocompatible. By evaluating different responses according to BCM, the most intense tissue reaction was noticed at HAP45, graded as severe, and mild to moderate for DC, HAP22 and alfa tricaltium phosphate., Svrha ove studije je bila procena tkivnog odgovora indukovanog biokeramič kim materijalima (BCM) inplantiranim u subkutano tkivo pacova. Trideset dva pacova je bilo podeljeno u sledećih 6 grupa: kontrolna grupa-neoperisana; inplantirane sa: dentalnom keramikom (DC); alfa trikalcijum fosfatima sintetisanim na 22 MPa (αTCP22) i na 45 MPa (αTCP45); hidroksiapatitom sintetisanim na 22 MPa (HAP22) i na 45 MPa (HAP45). Kontralateralne strane svih životinja bile su slepa kontrola i urađene su kao džepovi hirurške incizije u subkutanom tkivu. Eksperimentalne grupe su imale subkutano inplantirane biokeramičke materijale. Uzorci su sakupljeni posle 14 dana i sprovedeni u histološkoj proceduri, a inflamatorna reakcija je praćena mikroskopski. Inflamatorni infiltrat se sastojao od limfocita, polimorfonuklearnih leukocita, makrofaga i mastocita. Istovremeno su uočeni znaci rastuće fibroze oko mesta graftova. Inplantirana mesta u poređenju sa hirurškim ranama indukuju granulom karakterističnog tipa na strano telo sa posledičnom fibrozom oko graftova, kapsulom na dodirnoj površini sa BCM u subkutisu pacova, ne izazivajući uočljivu imunološ ku reakciju, tako da odgovor tkiva ukazuje na biokompatibilnost. Procenjivanjem odgovora sa različitim BCM, zabeležena je najintenzivnija (snažna) tkivna reakcija kod HAP45 inplanta, a blaga do umerena kod DC, HAP22 i alfa trikalcijumfosfata.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Histological and immunohistochemical evaluations of rat soft tissue response to bioceramical implants, Histološka i imunohistohemijska procena reakcije mekog tkiva pacova na biokeramičke implante",
volume = "59",
number = "2-3",
pages = "243-253",
doi = "10.2298/AVB0903243M"
}

Marković, D., Kojić, Z., Marinković, D., Danilović, V., Radovanović, A.,& Janaćković, Đ.. (2009). Histological and immunohistochemical evaluations of rat soft tissue response to bioceramical implants. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 59(2-3), 243-253.
https://doi.org/10.2298/AVB0903243M

Marković D, Kojić Z, Marinković D, Danilović V, Radovanović A, Janaćković Đ. Histological and immunohistochemical evaluations of rat soft tissue response to bioceramical implants. in Acta veterinaria. 2009;59(2-3):243-253.
doi:10.2298/AVB0903243M .

Marković, Danica, Kojić, Zvezdana, Marinković, D., Danilović, Vesna, Radovanović, Anita, Janaćković, Đorđe, "Histological and immunohistochemical evaluations of rat soft tissue response to bioceramical implants" in Acta veterinaria, 59, no. 2-3 (2009):243-253,
https://doi.org/10.2298/AVB0903243M . .

TY  - CONF
AU  - Jokić, Bojan
AU  - Janković-Castvan, I.
AU  - Veljović, Đorđe
AU  - Bucevac, D.
AU  - Obradović-Đuričić, Kosovka
AU  - Petrović, R.
AU  - Janaćković, Đorđe
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1364
AB  - The aim of this work is the investigation of alpha-tricalcium-phosphate (alpha-TCP) formation from calcium-deficient hydroxyapatite (CDHAP), synthesized by hydrothermal method from CaCl2, EDTA, NaH2PO4 center dot 2H(2)O and urea as precursors at 160 degrees C. Further, the influence of Ca/P ratios in the starting solution on alpha-TCP formation and the settings of obtained cements in simulated body fluid (SBF) were investigated. According to the results of X-ray, FTIR and SEM analyses, it is shown that CDHAP is transformed to beta-TCP at 800 degrees C, and to alpha-TCP at 1200 degrees C. Almost complete transformation of CDHAP into alpha-TCP occur after heating at 1500 degrees C in the case when Ca/P ratio in starting solution was 1,42. Cement powder mixed with the cement liquid (2.5 wt.% solution of Na2HPO4) completely hydrolyzes after 7 days in SBF, forming only CDHAP phase.
C3  - Journal of Optoelectronics & Advanced Materials
T1  - Synthesis and settings behavior of alpha-TCP from calcium deficient hyroxyapatite obtained by hydrothermal method
VL  - 9
IS  - 6
SP  - 1904
EP  - 1910
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2574
ER  - 

@conference{
author = "Jokić, Bojan and Janković-Castvan, I. and Veljović, Đorđe and Bucevac, D. and Obradović-Đuričić, Kosovka and Petrović, R. and Janaćković, Đorđe",
year = "2007",
abstract = "The aim of this work is the investigation of alpha-tricalcium-phosphate (alpha-TCP) formation from calcium-deficient hydroxyapatite (CDHAP), synthesized by hydrothermal method from CaCl2, EDTA, NaH2PO4 center dot 2H(2)O and urea as precursors at 160 degrees C. Further, the influence of Ca/P ratios in the starting solution on alpha-TCP formation and the settings of obtained cements in simulated body fluid (SBF) were investigated. According to the results of X-ray, FTIR and SEM analyses, it is shown that CDHAP is transformed to beta-TCP at 800 degrees C, and to alpha-TCP at 1200 degrees C. Almost complete transformation of CDHAP into alpha-TCP occur after heating at 1500 degrees C in the case when Ca/P ratio in starting solution was 1,42. Cement powder mixed with the cement liquid (2.5 wt.% solution of Na2HPO4) completely hydrolyzes after 7 days in SBF, forming only CDHAP phase.",
journal = "Journal of Optoelectronics & Advanced Materials",
title = "Synthesis and settings behavior of alpha-TCP from calcium deficient hyroxyapatite obtained by hydrothermal method",
volume = "9",
number = "6",
pages = "1904-1910",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2574"
}

Jokić, B., Janković-Castvan, I., Veljović, Đ., Bucevac, D., Obradović-Đuričić, K., Petrović, R.,& Janaćković, Đ.. (2007). Synthesis and settings behavior of alpha-TCP from calcium deficient hyroxyapatite obtained by hydrothermal method. in Journal of Optoelectronics & Advanced Materials, 9(6), 1904-1910.
https://hdl.handle.net/21.15107/rcub_vinar_2574

Jokić B, Janković-Castvan I, Veljović Đ, Bucevac D, Obradović-Đuričić K, Petrović R, Janaćković Đ. Synthesis and settings behavior of alpha-TCP from calcium deficient hyroxyapatite obtained by hydrothermal method. in Journal of Optoelectronics & Advanced Materials. 2007;9(6):1904-1910.
https://hdl.handle.net/21.15107/rcub_vinar_2574 .

Jokić, Bojan, Janković-Castvan, I., Veljović, Đorđe, Bucevac, D., Obradović-Đuričić, Kosovka, Petrović, R., Janaćković, Đorđe, "Synthesis and settings behavior of alpha-TCP from calcium deficient hyroxyapatite obtained by hydrothermal method" in Journal of Optoelectronics & Advanced Materials, 9, no. 6 (2007):1904-1910,
https://hdl.handle.net/21.15107/rcub_vinar_2574 .