TY  - JOUR
AU  - Nikolić, Ljubinka
AU  - Čakić, Saša
AU  - Perunović, Neda
AU  - Čolak, Emina
AU  - Kotur-Stevuljević, Jelena
AU  - Janković, Saša
AU  - Đurić, Milanko
AU  - Plećaš, Darko
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2496
AB  - Background/Aim. Preterm birth is defined as a delivery prior to the completed 37th week of gestation. Literature data suggested that periodontal processes may influence to the feto-placental unit and induce preterm delivery. The degree of the periodontal disease is influenced by secretor status. Pro-inflammatory cytokines are involved in periodontitis as well as in delivery. The combined influence of these factors on the risk of preterm birth has not been explored. The aim of our study was to investigate the associations between periodontal diseases, secretor status, and interleukin1-b (IL1-ß) and prostaglandine E2 (PGE2) levels in women delivered preterm. Methods. The study included 56 preterm delivery women and 56 women delivered at term as a control group, aged between 17 and 41 years. Periodontal examination, blood and saliva sampling were performed within 48 hours following delivery. Secretor phenotype was determined by hemagglutination inhibition method. The concentrations of IL1-ß and PGE2 were measured by high sensitivity Enzyme-linked Immunosorbent Assay (ELISA). Results. In the pre-term birth group there were 66.1% of women with periodontitis, while in the control one there were 12.5% (p  lt  0.01). Concentrations of IL1-ß and PGE2 in plasma were significantly higher in the non-secretor group of women who gave birth pre-term and had periodontitis comparing to other groups. There was a significant correlation between salivary and plasma levels of PGE2 and IL1-ß in the preterm birth group (R = 0.416, p = 0.017 and R = -0.592, p  lt  0.001, respectively). There were no such correlations in women who delivered at term. Conclusion. Our results support the hypothesis that non-secretor phenotype and periodontitis are at least in part responsible for pathogenesis of preterm birth. This probability of negative impact of non-secretor status cannot be ignored. These findings support the need for additional research into the biology of human parturition.
AB  - Uvod/Cilj. Prevremeni porođaj se definiše kao porođaj pre navršene 37 nedelje gestacije. Podaci iz literature govore u prilog tome da periodontalni procesi mogu uticati na fetoplacentalnu jedinicu i indukovati preterminski porođaj. Sekretorni status može uticati na stepen periodontalne bolesti. Proinflamatorni citokini imaju uticaj na periodontitis kao i na porođaj. Kombinovani uticaj ovih faktora rizika za prevremeni porođaj nije dovoljno istražen. Cilj ove studije je bio da istraži povezanost između periodontalne bolesti, sekretornog statusa, nivoa interleukina 1-b (IL1-b) i prostaglandina E2 (PGE2) kod žena koje su imale prevremeni porođaj. Metode. Studijom je bilo obuhvaćeno 56 žena, koje su imale prevremen porođaj i 56 žena u kontrolnoj grupi koje su se porodile u terminu, starosti između 17 i 41 godine. Periodontalni pregled, uzorkovanje krvi i salive je izvršeno u prvih 48 sati po porođaju. Sekretorni status je određen metodom inhibicije hemaglutinacije. Koncentracije IL1-b i PGE2 su merene visoko senzitivnim Enzyme-linked Immunosorbent Assay (ELISA) testom. Rezultati. U grupi prevremenih porođaja bilo je 66,1% žena sa periodontitisom, a u kontrolnoj grupi 12,5% (p  lt  0.01). Prevremeno porođene žena, nesekretori sa periodontitisom imale su u plazmi značajno više vrednosti IL 1-b i PGE 2 u odnosu na ostale grupe (p  lt  0,01). U grupi prevremeno porođenih žena postojala je značajna korelacija između salivarnih i plazmatskih koncentracija PGE2 i IL1-b (R = 0.416, p = 0.017 i R = -0,592, p  lt  0,001, redom). Ove korelacije nisu postojale kod žena koje su imale terminski porođaj. Zaključak. Naši rezultati podržavaju hipotezu da su sekretorni status i periodontitis, bar delimično, odgovorni za patogenezu preterminskog porođaja. Verovatnoća negativnog uticaja nesekretornog statusa se ne sme ignorisati. Ovi zaključci ukazuju na potrebu za dodatnim istraživanjima porođaja.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Salivary and plasma inflammatory mediators and secretory status in preterm delivery women with periodontitis: A cross sectional study
T1  - Salivarni i inflamatorni medijatori plazme i sekretorni status prevremeno porođenih žena sa periodontitisom - studija preseka
VL  - 77
IS  - 3
SP  - 247
EP  - 255
DO  - 10.2298/VSP171106066N
ER  - 

@article{
author = "Nikolić, Ljubinka and Čakić, Saša and Perunović, Neda and Čolak, Emina and Kotur-Stevuljević, Jelena and Janković, Saša and Đurić, Milanko and Plećaš, Darko",
year = "2020",
abstract = "Background/Aim. Preterm birth is defined as a delivery prior to the completed 37th week of gestation. Literature data suggested that periodontal processes may influence to the feto-placental unit and induce preterm delivery. The degree of the periodontal disease is influenced by secretor status. Pro-inflammatory cytokines are involved in periodontitis as well as in delivery. The combined influence of these factors on the risk of preterm birth has not been explored. The aim of our study was to investigate the associations between periodontal diseases, secretor status, and interleukin1-b (IL1-ß) and prostaglandine E2 (PGE2) levels in women delivered preterm. Methods. The study included 56 preterm delivery women and 56 women delivered at term as a control group, aged between 17 and 41 years. Periodontal examination, blood and saliva sampling were performed within 48 hours following delivery. Secretor phenotype was determined by hemagglutination inhibition method. The concentrations of IL1-ß and PGE2 were measured by high sensitivity Enzyme-linked Immunosorbent Assay (ELISA). Results. In the pre-term birth group there were 66.1% of women with periodontitis, while in the control one there were 12.5% (p  lt  0.01). Concentrations of IL1-ß and PGE2 in plasma were significantly higher in the non-secretor group of women who gave birth pre-term and had periodontitis comparing to other groups. There was a significant correlation between salivary and plasma levels of PGE2 and IL1-ß in the preterm birth group (R = 0.416, p = 0.017 and R = -0.592, p  lt  0.001, respectively). There were no such correlations in women who delivered at term. Conclusion. Our results support the hypothesis that non-secretor phenotype and periodontitis are at least in part responsible for pathogenesis of preterm birth. This probability of negative impact of non-secretor status cannot be ignored. These findings support the need for additional research into the biology of human parturition., Uvod/Cilj. Prevremeni porođaj se definiše kao porođaj pre navršene 37 nedelje gestacije. Podaci iz literature govore u prilog tome da periodontalni procesi mogu uticati na fetoplacentalnu jedinicu i indukovati preterminski porođaj. Sekretorni status može uticati na stepen periodontalne bolesti. Proinflamatorni citokini imaju uticaj na periodontitis kao i na porođaj. Kombinovani uticaj ovih faktora rizika za prevremeni porođaj nije dovoljno istražen. Cilj ove studije je bio da istraži povezanost između periodontalne bolesti, sekretornog statusa, nivoa interleukina 1-b (IL1-b) i prostaglandina E2 (PGE2) kod žena koje su imale prevremeni porođaj. Metode. Studijom je bilo obuhvaćeno 56 žena, koje su imale prevremen porođaj i 56 žena u kontrolnoj grupi koje su se porodile u terminu, starosti između 17 i 41 godine. Periodontalni pregled, uzorkovanje krvi i salive je izvršeno u prvih 48 sati po porođaju. Sekretorni status je određen metodom inhibicije hemaglutinacije. Koncentracije IL1-b i PGE2 su merene visoko senzitivnim Enzyme-linked Immunosorbent Assay (ELISA) testom. Rezultati. U grupi prevremenih porođaja bilo je 66,1% žena sa periodontitisom, a u kontrolnoj grupi 12,5% (p  lt  0.01). Prevremeno porođene žena, nesekretori sa periodontitisom imale su u plazmi značajno više vrednosti IL 1-b i PGE 2 u odnosu na ostale grupe (p  lt  0,01). U grupi prevremeno porođenih žena postojala je značajna korelacija između salivarnih i plazmatskih koncentracija PGE2 i IL1-b (R = 0.416, p = 0.017 i R = -0,592, p  lt  0,001, redom). Ove korelacije nisu postojale kod žena koje su imale terminski porođaj. Zaključak. Naši rezultati podržavaju hipotezu da su sekretorni status i periodontitis, bar delimično, odgovorni za patogenezu preterminskog porođaja. Verovatnoća negativnog uticaja nesekretornog statusa se ne sme ignorisati. Ovi zaključci ukazuju na potrebu za dodatnim istraživanjima porođaja.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Salivary and plasma inflammatory mediators and secretory status in preterm delivery women with periodontitis: A cross sectional study, Salivarni i inflamatorni medijatori plazme i sekretorni status prevremeno porođenih žena sa periodontitisom - studija preseka",
volume = "77",
number = "3",
pages = "247-255",
doi = "10.2298/VSP171106066N"
}

Nikolić, L., Čakić, S., Perunović, N., Čolak, E., Kotur-Stevuljević, J., Janković, S., Đurić, M.,& Plećaš, D.. (2020). Salivary and plasma inflammatory mediators and secretory status in preterm delivery women with periodontitis: A cross sectional study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 77(3), 247-255.
https://doi.org/10.2298/VSP171106066N

Nikolić L, Čakić S, Perunović N, Čolak E, Kotur-Stevuljević J, Janković S, Đurić M, Plećaš D. Salivary and plasma inflammatory mediators and secretory status in preterm delivery women with periodontitis: A cross sectional study. in Vojnosanitetski pregled. 2020;77(3):247-255.
doi:10.2298/VSP171106066N .

Nikolić, Ljubinka, Čakić, Saša, Perunović, Neda, Čolak, Emina, Kotur-Stevuljević, Jelena, Janković, Saša, Đurić, Milanko, Plećaš, Darko, "Salivary and plasma inflammatory mediators and secretory status in preterm delivery women with periodontitis: A cross sectional study" in Vojnosanitetski pregled, 77, no. 3 (2020):247-255,
https://doi.org/10.2298/VSP171106066N . .

TY  - JOUR
AU  - Kadović, Jana
AU  - Novaković, Nada
AU  - Vučković, Mila
AU  - Đorđević, Vladan
AU  - Petrović, Vanja
AU  - Stojčev-Stajčić, Ljiljana
AU  - Čakić, Saša
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2447
AB  - Background/Aim. Knowledge of numerous variations in anatomical features of furcation area is a prerequisite for the achievement of more predictable results in the therapy of multi-rooted teeth with furcation involvement (FI). The aim of the study was to evaluate the morphological characteristics of extracted molars of adult population in Belgrade, Serbia. Methods. In total, 468 extracted first and second molars, both mandibular and maxillary, were measured. The values of root trunk lengths and root lengths, diameter of furcation entrances (FE), distance between the roots and depth of root concavity were analysed. Results. The maxillary first molars had significantly higher root trunk lengths values than the second molars. As for the mandibular molars, FE was smaller than 1 mm. The distance between the roots was more than 2 mm at the third level of measurement. Conclusion. The buccal FE of maxillary molars was the lowest. The root concavity of the second mandibular molars was higher from the lingual aspect.
AB  - Uvod/Cilj. Poznavanje mnogobrojnih varijacija anatomskih karakteristika furkacija (furkacionih regija) je preduslov za postizanje predvidivih rezultata terapije furkacionih defekata višekorenih zuba. Cilj ovog istraživanja je bio procena morfološke karakteristike izvađenih zuba adultne populacije u Beogradu. Metode. Merenja su vršena na ukupno 468 izvađenih prvih i drugih molara i gornje i donje vilice. Analizirane su izmerene vrednosti dužine korenskog stabla i dužine korenova, prečnik ulaza u furkaciju, odstojanje između korenova i dubina korenskog konkaviteta. Rezultati. Prvi gornji molari su imali signifikantno veće vrednosti dužine korenskog stabla od drugih gornjih molara. Kod donjih molara, prečnik ulaska u furkaciju bio je manji od 1 mm. Na trećem nivou merenja, odstojanje između korenova imalo je vrednost veću od 2 mm. Zaključak. Prečnik ulaska u furkaciju sa bukalne strane gornjih molara bio je najmanji. Dubina korenskog konkaviteta drugih donjih molara bila je veća sa lingvalne strane.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Anatomical characteristics of the furcation area and root surfaces of multi-rooted teeth: Epidemiological study
T1  - Anatomske karakteristike furkacija i korenova višekorenih zuba - epidemiološka studija
VL  - 76
IS  - 8
SP  - 761
EP  - 771
DO  - 10.2298/VSP170308149K
ER  - 

@article{
author = "Kadović, Jana and Novaković, Nada and Vučković, Mila and Đorđević, Vladan and Petrović, Vanja and Stojčev-Stajčić, Ljiljana and Čakić, Saša",
year = "2019",
abstract = "Background/Aim. Knowledge of numerous variations in anatomical features of furcation area is a prerequisite for the achievement of more predictable results in the therapy of multi-rooted teeth with furcation involvement (FI). The aim of the study was to evaluate the morphological characteristics of extracted molars of adult population in Belgrade, Serbia. Methods. In total, 468 extracted first and second molars, both mandibular and maxillary, were measured. The values of root trunk lengths and root lengths, diameter of furcation entrances (FE), distance between the roots and depth of root concavity were analysed. Results. The maxillary first molars had significantly higher root trunk lengths values than the second molars. As for the mandibular molars, FE was smaller than 1 mm. The distance between the roots was more than 2 mm at the third level of measurement. Conclusion. The buccal FE of maxillary molars was the lowest. The root concavity of the second mandibular molars was higher from the lingual aspect., Uvod/Cilj. Poznavanje mnogobrojnih varijacija anatomskih karakteristika furkacija (furkacionih regija) je preduslov za postizanje predvidivih rezultata terapije furkacionih defekata višekorenih zuba. Cilj ovog istraživanja je bio procena morfološke karakteristike izvađenih zuba adultne populacije u Beogradu. Metode. Merenja su vršena na ukupno 468 izvađenih prvih i drugih molara i gornje i donje vilice. Analizirane su izmerene vrednosti dužine korenskog stabla i dužine korenova, prečnik ulaza u furkaciju, odstojanje između korenova i dubina korenskog konkaviteta. Rezultati. Prvi gornji molari su imali signifikantno veće vrednosti dužine korenskog stabla od drugih gornjih molara. Kod donjih molara, prečnik ulaska u furkaciju bio je manji od 1 mm. Na trećem nivou merenja, odstojanje između korenova imalo je vrednost veću od 2 mm. Zaključak. Prečnik ulaska u furkaciju sa bukalne strane gornjih molara bio je najmanji. Dubina korenskog konkaviteta drugih donjih molara bila je veća sa lingvalne strane.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Anatomical characteristics of the furcation area and root surfaces of multi-rooted teeth: Epidemiological study, Anatomske karakteristike furkacija i korenova višekorenih zuba - epidemiološka studija",
volume = "76",
number = "8",
pages = "761-771",
doi = "10.2298/VSP170308149K"
}

Kadović, J., Novaković, N., Vučković, M., Đorđević, V., Petrović, V., Stojčev-Stajčić, L.,& Čakić, S.. (2019). Anatomical characteristics of the furcation area and root surfaces of multi-rooted teeth: Epidemiological study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(8), 761-771.
https://doi.org/10.2298/VSP170308149K

Kadović J, Novaković N, Vučković M, Đorđević V, Petrović V, Stojčev-Stajčić L, Čakić S. Anatomical characteristics of the furcation area and root surfaces of multi-rooted teeth: Epidemiological study. in Vojnosanitetski pregled. 2019;76(8):761-771.
doi:10.2298/VSP170308149K .

Kadović, Jana, Novaković, Nada, Vučković, Mila, Đorđević, Vladan, Petrović, Vanja, Stojčev-Stajčić, Ljiljana, Čakić, Saša, "Anatomical characteristics of the furcation area and root surfaces of multi-rooted teeth: Epidemiological study" in Vojnosanitetski pregled, 76, no. 8 (2019):761-771,
https://doi.org/10.2298/VSP170308149K . .

TY  - JOUR
AU  - Pejčić, Nataša
AU  - Petrović, Vanja
AU  - Marković, Dejan
AU  - Miličić, Biljana
AU  - Ilic-Dimitrijević, Ivana
AU  - Perunović, Neda
AU  - Čakić, Saša
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2205
AB  - BACKGROUND: Dentists have a high prevalence of musculoskeletal (MS) pain, which is the most common symptom associated with work-related musculoskeletal disorders (WMSDs). To overcome this problem, identification of the risk factors and preventive measures for MS pain are of paramount importance to dentists in order to improve their quality of life and work. OBJECTIVES: The aims of this study were to recognize the risk factors for MS pain and their impact on dental work, as well as to identify preventive measures of MS pain among dentists. METHODS: Self-reporting questionnaire consisting of 78 questions was exclusively developed for the study and sent to 500 working active dentists in Serbia. RESULTS: Response rate was 71.2% (356 dentists). The prevalence of MS pain was 82.6% among dentists. The main risk factors for MS pain were advanced age, female dentists, presence of chronic diseases, long working hours, and high frequency of treated patients. The most effective preventive measures in preventing MS pain were massage treatments and physical activities. Followed by use of ergonomically designed equipment, correct and dynamic working positions, and an adequate workflow organization. CONCLUSION: The risk factors for MS pain and their impact on dental work should widely be disseminated among dentists. Importantly, proper implementation in everyday life of adequate preventive measures is essential for preventing MS pain and development of WMSDs.
PB  - Ios Press, Amsterdam
T2  - Work - A Journal of Prevention Assessment & Rehabilitation
T1  - Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists
VL  - 57
IS  - 4
SP  - 573
EP  - 593
DO  - 10.3233/WOR-172588
ER  - 

@article{
author = "Pejčić, Nataša and Petrović, Vanja and Marković, Dejan and Miličić, Biljana and Ilic-Dimitrijević, Ivana and Perunović, Neda and Čakić, Saša",
year = "2017",
abstract = "BACKGROUND: Dentists have a high prevalence of musculoskeletal (MS) pain, which is the most common symptom associated with work-related musculoskeletal disorders (WMSDs). To overcome this problem, identification of the risk factors and preventive measures for MS pain are of paramount importance to dentists in order to improve their quality of life and work. OBJECTIVES: The aims of this study were to recognize the risk factors for MS pain and their impact on dental work, as well as to identify preventive measures of MS pain among dentists. METHODS: Self-reporting questionnaire consisting of 78 questions was exclusively developed for the study and sent to 500 working active dentists in Serbia. RESULTS: Response rate was 71.2% (356 dentists). The prevalence of MS pain was 82.6% among dentists. The main risk factors for MS pain were advanced age, female dentists, presence of chronic diseases, long working hours, and high frequency of treated patients. The most effective preventive measures in preventing MS pain were massage treatments and physical activities. Followed by use of ergonomically designed equipment, correct and dynamic working positions, and an adequate workflow organization. CONCLUSION: The risk factors for MS pain and their impact on dental work should widely be disseminated among dentists. Importantly, proper implementation in everyday life of adequate preventive measures is essential for preventing MS pain and development of WMSDs.",
publisher = "Ios Press, Amsterdam",
journal = "Work - A Journal of Prevention Assessment & Rehabilitation",
title = "Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists",
volume = "57",
number = "4",
pages = "573-593",
doi = "10.3233/WOR-172588"
}

Pejčić, N., Petrović, V., Marković, D., Miličić, B., Ilic-Dimitrijević, I., Perunović, N.,& Čakić, S.. (2017). Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists. in Work - A Journal of Prevention Assessment & Rehabilitation
Ios Press, Amsterdam., 57(4), 573-593.
https://doi.org/10.3233/WOR-172588

Pejčić N, Petrović V, Marković D, Miličić B, Ilic-Dimitrijević I, Perunović N, Čakić S. Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists. in Work - A Journal of Prevention Assessment & Rehabilitation. 2017;57(4):573-593.
doi:10.3233/WOR-172588 .

Pejčić, Nataša, Petrović, Vanja, Marković, Dejan, Miličić, Biljana, Ilic-Dimitrijević, Ivana, Perunović, Neda, Čakić, Saša, "Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists" in Work - A Journal of Prevention Assessment & Rehabilitation, 57, no. 4 (2017):573-593,
https://doi.org/10.3233/WOR-172588 . .

TY  - JOUR
AU  - Cicmil, Ana
AU  - Govedarica, Olivera
AU  - Lečić, Jelena
AU  - Mališ, Snežana
AU  - Cicmil, Smiljka
AU  - Čakić, Saša
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2245
AB  - Background: Good glycoregulation at patients with diabetes mellitus is essential for prevention of many complications, including those in oral cavity. Results of numerous studies indicate that xerostomia and neurosensory oral disorders are present in type 2 diabetics. A review of the literature shows contradictory results about prevalence of oral mucosal lesions in diabetics. The aim of this study was to evaluate the presence of xerostomia, neurosensory disorders and mucosal lesions in oral cavity of type 2 diabetics. Material and Methods: This study involved 90 adults, 60 with type 2 diabetes and 30 healthy subjects, aged 45-65 years. With regard to value of HbA1c level diabetics were divided into two groups: 30 subjects with satisfactory glycoregulation (HbA1c lt 9%) and 30 subjects with poor glycoregulation (HbA1c≥9%). All patients recruited into the study completed a questionnaire that included their demographic, medical and oral health data. Clinical examination of the oral mucosa was performed by a single examiner. Results: In relation to the presence of xerostomia and dysgeusia between satisfactory controlled diabetics and healthy subjects a significant difference was observed (p lt 0.05). Compared with healthy subjects, poor controlled diabetics had significantly higher presence of xerostomia (p lt 0.001) and neurosensory disorders (p lt 0.05). A higher prevalence of oral mucosal lesions was found in poor controlled diabetics, but significant difference between groups was not observed (p>0.05). A significant positive correlation was revealed between smoking and glossodynia as well as smoking and glossopyrosis (p>0.05). Conclusion: Glycemic control level seems to influence the susceptibility of type 2 diabetics to xerostomia and neurosensory disorders. Less clear is whether diabetes are correlated to oral mucosal lesions.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Dental Medicine
T1  - Oral symptoms and mucosal lesions in patients with diabetes mellitus type 2
VL  - 21
IS  - 1
SP  - 50
EP  - 54
DO  - 10.1515/bjdm-2017-0007
ER  - 

@article{
author = "Cicmil, Ana and Govedarica, Olivera and Lečić, Jelena and Mališ, Snežana and Cicmil, Smiljka and Čakić, Saša",
year = "2017",
abstract = "Background: Good glycoregulation at patients with diabetes mellitus is essential for prevention of many complications, including those in oral cavity. Results of numerous studies indicate that xerostomia and neurosensory oral disorders are present in type 2 diabetics. A review of the literature shows contradictory results about prevalence of oral mucosal lesions in diabetics. The aim of this study was to evaluate the presence of xerostomia, neurosensory disorders and mucosal lesions in oral cavity of type 2 diabetics. Material and Methods: This study involved 90 adults, 60 with type 2 diabetes and 30 healthy subjects, aged 45-65 years. With regard to value of HbA1c level diabetics were divided into two groups: 30 subjects with satisfactory glycoregulation (HbA1c lt 9%) and 30 subjects with poor glycoregulation (HbA1c≥9%). All patients recruited into the study completed a questionnaire that included their demographic, medical and oral health data. Clinical examination of the oral mucosa was performed by a single examiner. Results: In relation to the presence of xerostomia and dysgeusia between satisfactory controlled diabetics and healthy subjects a significant difference was observed (p lt 0.05). Compared with healthy subjects, poor controlled diabetics had significantly higher presence of xerostomia (p lt 0.001) and neurosensory disorders (p lt 0.05). A higher prevalence of oral mucosal lesions was found in poor controlled diabetics, but significant difference between groups was not observed (p>0.05). A significant positive correlation was revealed between smoking and glossodynia as well as smoking and glossopyrosis (p>0.05). Conclusion: Glycemic control level seems to influence the susceptibility of type 2 diabetics to xerostomia and neurosensory disorders. Less clear is whether diabetes are correlated to oral mucosal lesions.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Dental Medicine",
title = "Oral symptoms and mucosal lesions in patients with diabetes mellitus type 2",
volume = "21",
number = "1",
pages = "50-54",
doi = "10.1515/bjdm-2017-0007"
}

Cicmil, A., Govedarica, O., Lečić, J., Mališ, S., Cicmil, S.,& Čakić, S.. (2017). Oral symptoms and mucosal lesions in patients with diabetes mellitus type 2. in Balkan Journal of Dental Medicine
Udruženje stomatologa Balkana., 21(1), 50-54.
https://doi.org/10.1515/bjdm-2017-0007

Cicmil A, Govedarica O, Lečić J, Mališ S, Cicmil S, Čakić S. Oral symptoms and mucosal lesions in patients with diabetes mellitus type 2. in Balkan Journal of Dental Medicine. 2017;21(1):50-54.
doi:10.1515/bjdm-2017-0007 .

Cicmil, Ana, Govedarica, Olivera, Lečić, Jelena, Mališ, Snežana, Cicmil, Smiljka, Čakić, Saša, "Oral symptoms and mucosal lesions in patients with diabetes mellitus type 2" in Balkan Journal of Dental Medicine, 21, no. 1 (2017):50-54,
https://doi.org/10.1515/bjdm-2017-0007 . .

TY  - JOUR
AU  - Lečić, Jelena
AU  - Čakić, Saša
AU  - Janjic-Pavlović, Ognjenka
AU  - Cicmil, Ana
AU  - Vukotić, Olivera
AU  - Petrović, Vanja
AU  - Cicmil, Smiljka
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2087
AB  - Objective: The aim of this study was to evaluate clinical efficacy of different chlorhexidine gluconate (CHX) preparations applied subgingivally as an adjunct to scaling and root planing (SRP).Material and methods: A total of 120 periodontal pockets was included in this randomized, controlled, split mouth designed study. According to protocols used in treatment, periodontal pockets were assigned to experimental and control groups as follows: CHX solution as an addition to SRP versus control SRP group; CHX gel as an addition to SRP versus control SRP; CHX chip as an addition to SRP versus control SRP group. Following clinical parameters were recorded at baseline, one and three months after the baseline: plaque index (PI), probing pocket depth (PPD), bleeding index (BI) and clinical attachment level (CAL).Results: The most significant improvements were found concerning PI in CHX solution with SRP and CHX gel with SRP groups over controls at one month recall, as well as concerning BI and PPD in CHX chip with SRP group over SRP alone at three-month recall.Conclusion: Results of this study favour combination therapy using CHX chip as an adjunct to SRP due to greater improvements in BI and PPD compared to those obtained by SRP alone in the treatment of chronic periodontitis.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Acta Odontologica Scandinavica
T1  - Different methods for subgingival application of chlorhexidine in the treatment of patients with chronic periodontitis
VL  - 74
IS  - 6
SP  - 502
EP  - 507
DO  - 10.1080/00016357.2016.1206964
ER  - 

@article{
author = "Lečić, Jelena and Čakić, Saša and Janjic-Pavlović, Ognjenka and Cicmil, Ana and Vukotić, Olivera and Petrović, Vanja and Cicmil, Smiljka",
year = "2016",
abstract = "Objective: The aim of this study was to evaluate clinical efficacy of different chlorhexidine gluconate (CHX) preparations applied subgingivally as an adjunct to scaling and root planing (SRP).Material and methods: A total of 120 periodontal pockets was included in this randomized, controlled, split mouth designed study. According to protocols used in treatment, periodontal pockets were assigned to experimental and control groups as follows: CHX solution as an addition to SRP versus control SRP group; CHX gel as an addition to SRP versus control SRP; CHX chip as an addition to SRP versus control SRP group. Following clinical parameters were recorded at baseline, one and three months after the baseline: plaque index (PI), probing pocket depth (PPD), bleeding index (BI) and clinical attachment level (CAL).Results: The most significant improvements were found concerning PI in CHX solution with SRP and CHX gel with SRP groups over controls at one month recall, as well as concerning BI and PPD in CHX chip with SRP group over SRP alone at three-month recall.Conclusion: Results of this study favour combination therapy using CHX chip as an adjunct to SRP due to greater improvements in BI and PPD compared to those obtained by SRP alone in the treatment of chronic periodontitis.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Acta Odontologica Scandinavica",
title = "Different methods for subgingival application of chlorhexidine in the treatment of patients with chronic periodontitis",
volume = "74",
number = "6",
pages = "502-507",
doi = "10.1080/00016357.2016.1206964"
}

Lečić, J., Čakić, S., Janjic-Pavlović, O., Cicmil, A., Vukotić, O., Petrović, V.,& Cicmil, S.. (2016). Different methods for subgingival application of chlorhexidine in the treatment of patients with chronic periodontitis. in Acta Odontologica Scandinavica
Taylor & Francis Ltd, Abingdon., 74(6), 502-507.
https://doi.org/10.1080/00016357.2016.1206964

Lečić J, Čakić S, Janjic-Pavlović O, Cicmil A, Vukotić O, Petrović V, Cicmil S. Different methods for subgingival application of chlorhexidine in the treatment of patients with chronic periodontitis. in Acta Odontologica Scandinavica. 2016;74(6):502-507.
doi:10.1080/00016357.2016.1206964 .

Lečić, Jelena, Čakić, Saša, Janjic-Pavlović, Ognjenka, Cicmil, Ana, Vukotić, Olivera, Petrović, Vanja, Cicmil, Smiljka, "Different methods for subgingival application of chlorhexidine in the treatment of patients with chronic periodontitis" in Acta Odontologica Scandinavica, 74, no. 6 (2016):502-507,
https://doi.org/10.1080/00016357.2016.1206964 . .

TY  - JOUR
AU  - Perunović, Neda
AU  - Rakić, Mia
AU  - Nikolić, Ljubinka
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Plećaš, Darko
AU  - Madianos, Phoebus N.
AU  - Čakić, Saša
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2137
AB  - Background: Periodontitis is considered to be a risk factor for preterm birth. Mechanisms have been proposed for this pathologic relation, but the exact pathologic pattern remains unclear. Therefore, the objective of the present study is to evaluate levels of four major labor triggers, prostaglandin E-2 (PGE(2)), interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha, in gingival crevicular fluid (GCF) and serum samples between women with preterm birth (PTB) and full-term birth (FTB) and correlate them with periodontal parameters. Methods: PGE(2), IL-1 beta, IL-6, and TNF-alpha levels were estimated using enzyme-linked immunosorbent assays in GCF and serum samples collected 24 to 48 hours after labor from 120 women (60 FTB, 60 PTB). Results: Women with PTB exhibited significantly more periodontitis, worse periodontal parameters, and increased GCF levels of IL-6 and PGE(2) compared with the FTB group; there were no significant differences in serum levels of measured markers. GCF levels of IL-1 beta, IL-6, and PGE(2) and serum levels of TNF-alpha and PGE(2) were significantly higher in women with periodontitis compared with periodontally healthy women. Serum levels of PGE(2) were positively correlated with probing depth (PD) and clinical attachment level (CAL) as well as with GCF levels of TNF-alpha in women with PTB. Conclusions: Women with PTB demonstrated worse periodontal parameters and significantly increased GCF levels of IL-6 and PGE(2) compared with those with FTB. Based on significant correlations among serum PGE(2) and PD, CAL, and GCF TNF-alpha in PTB, periodontitis may cause an overall increase of labor triggers and hence contribute to preterm labor onset.
PB  - Wiley, Hoboken
T2  - Journal of Periodontology
T1  - The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study
VL  - 87
IS  - 3
SP  - 248
EP  - 256
DO  - 10.1902/jop.2015.150364
ER  - 

@article{
author = "Perunović, Neda and Rakić, Mia and Nikolić, Ljubinka and Janković, Saša and Aleksić, Zoran and Plećaš, Darko and Madianos, Phoebus N. and Čakić, Saša",
year = "2016",
abstract = "Background: Periodontitis is considered to be a risk factor for preterm birth. Mechanisms have been proposed for this pathologic relation, but the exact pathologic pattern remains unclear. Therefore, the objective of the present study is to evaluate levels of four major labor triggers, prostaglandin E-2 (PGE(2)), interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha, in gingival crevicular fluid (GCF) and serum samples between women with preterm birth (PTB) and full-term birth (FTB) and correlate them with periodontal parameters. Methods: PGE(2), IL-1 beta, IL-6, and TNF-alpha levels were estimated using enzyme-linked immunosorbent assays in GCF and serum samples collected 24 to 48 hours after labor from 120 women (60 FTB, 60 PTB). Results: Women with PTB exhibited significantly more periodontitis, worse periodontal parameters, and increased GCF levels of IL-6 and PGE(2) compared with the FTB group; there were no significant differences in serum levels of measured markers. GCF levels of IL-1 beta, IL-6, and PGE(2) and serum levels of TNF-alpha and PGE(2) were significantly higher in women with periodontitis compared with periodontally healthy women. Serum levels of PGE(2) were positively correlated with probing depth (PD) and clinical attachment level (CAL) as well as with GCF levels of TNF-alpha in women with PTB. Conclusions: Women with PTB demonstrated worse periodontal parameters and significantly increased GCF levels of IL-6 and PGE(2) compared with those with FTB. Based on significant correlations among serum PGE(2) and PD, CAL, and GCF TNF-alpha in PTB, periodontitis may cause an overall increase of labor triggers and hence contribute to preterm labor onset.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontology",
title = "The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study",
volume = "87",
number = "3",
pages = "248-256",
doi = "10.1902/jop.2015.150364"
}

Perunović, N., Rakić, M., Nikolić, L., Janković, S., Aleksić, Z., Plećaš, D., Madianos, P. N.,& Čakić, S.. (2016). The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study. in Journal of Periodontology
Wiley, Hoboken., 87(3), 248-256.
https://doi.org/10.1902/jop.2015.150364

Perunović N, Rakić M, Nikolić L, Janković S, Aleksić Z, Plećaš D, Madianos PN, Čakić S. The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study. in Journal of Periodontology. 2016;87(3):248-256.
doi:10.1902/jop.2015.150364 .

Perunović, Neda, Rakić, Mia, Nikolić, Ljubinka, Janković, Saša, Aleksić, Zoran, Plećaš, Darko, Madianos, Phoebus N., Čakić, Saša, "The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study" in Journal of Periodontology, 87, no. 3 (2016):248-256,
https://doi.org/10.1902/jop.2015.150364 . .

TY  - JOUR
AU  - Milinković, Iva
AU  - Aleksić, Zoran
AU  - Janković, Saša
AU  - Popović, O.
AU  - Bajić, Miljan
AU  - Čakić, Saša
AU  - Leković, Vojislav
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1977
AB  - Background and ObjectiveGingival recession is defined as soft and hard tissue displacement resulting in root surface exposure. The optimal outcome of gingival recession treatment is complete, predictable and long-lasting root coverage with a significant level of tissue regeneration. Tissue engineering, which applies active regeneration principles, presents the contemporary treatment approach in the restitution and regeneration of lost tissues. The objective of the present study was to evaluate and compare the clinical results of application of an autologous fibroblast cell culture (AFCC) on a collagen matrix and a connective tissue graft (CTG) placed under a coronally advanced flap (CAF), in the treatment of single and multiple gingival recessions. Material and MethodsEighteen patients from the Department of Periodontology, School of Dentistry, University of Belgrade, were randomly enrolled in this study. Inclusion criteria were the bilateral presence of Miller Class I or II single or multiple maxillary gingival recessions. A split-mouth design was used in the study. The experimental group was treated with AFCC on a collagen scaffold, which was placed under a CAF. The control group received a combination of CTG and CAF. Clinical parameters such as gingival recession coverage, keratinized tissue width, clinical attachment level and gingival index were recorded at baseline and at 12mo postoperatively. The oral hygiene level was assessed by plaque index evaluation. Postoperative healing was evaluated through the healing index, recorded 1, 2 and 3wk postoperatively. The final esthetic outcome was assessed using the mean root coverage esthetic score (RES). ResultsStatistically significant improvement of all parameters assessed was found compared with baseline. A statistically significant difference between groups was observed only in keratinized tissue width. Greater keratinized tissue width is still obtained with the use of CTG. Regarding the tissue-healing results, no statistically significant difference was achieved. The RES results were similar for both groups. ConclusionsWithin the limitations of the present study, both procedures proved to be efficient in gingival recession treatment. AFCC, as a novel tissue-engineering concept and living cell-based therapy, proved to be a reliable and successful treatment concept.
PB  - Wiley, Hoboken
T2  - Journal of Periodontal Research
T1  - Clinical application of autologous fibroblast cell culture in gingival recession treatment
VL  - 50
IS  - 3
SP  - 363
EP  - 370
DO  - 10.1111/jre.12215
ER  - 

@article{
author = "Milinković, Iva and Aleksić, Zoran and Janković, Saša and Popović, O. and Bajić, Miljan and Čakić, Saša and Leković, Vojislav",
year = "2015",
abstract = "Background and ObjectiveGingival recession is defined as soft and hard tissue displacement resulting in root surface exposure. The optimal outcome of gingival recession treatment is complete, predictable and long-lasting root coverage with a significant level of tissue regeneration. Tissue engineering, which applies active regeneration principles, presents the contemporary treatment approach in the restitution and regeneration of lost tissues. The objective of the present study was to evaluate and compare the clinical results of application of an autologous fibroblast cell culture (AFCC) on a collagen matrix and a connective tissue graft (CTG) placed under a coronally advanced flap (CAF), in the treatment of single and multiple gingival recessions. Material and MethodsEighteen patients from the Department of Periodontology, School of Dentistry, University of Belgrade, were randomly enrolled in this study. Inclusion criteria were the bilateral presence of Miller Class I or II single or multiple maxillary gingival recessions. A split-mouth design was used in the study. The experimental group was treated with AFCC on a collagen scaffold, which was placed under a CAF. The control group received a combination of CTG and CAF. Clinical parameters such as gingival recession coverage, keratinized tissue width, clinical attachment level and gingival index were recorded at baseline and at 12mo postoperatively. The oral hygiene level was assessed by plaque index evaluation. Postoperative healing was evaluated through the healing index, recorded 1, 2 and 3wk postoperatively. The final esthetic outcome was assessed using the mean root coverage esthetic score (RES). ResultsStatistically significant improvement of all parameters assessed was found compared with baseline. A statistically significant difference between groups was observed only in keratinized tissue width. Greater keratinized tissue width is still obtained with the use of CTG. Regarding the tissue-healing results, no statistically significant difference was achieved. The RES results were similar for both groups. ConclusionsWithin the limitations of the present study, both procedures proved to be efficient in gingival recession treatment. AFCC, as a novel tissue-engineering concept and living cell-based therapy, proved to be a reliable and successful treatment concept.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontal Research",
title = "Clinical application of autologous fibroblast cell culture in gingival recession treatment",
volume = "50",
number = "3",
pages = "363-370",
doi = "10.1111/jre.12215"
}

Milinković, I., Aleksić, Z., Janković, S., Popović, O., Bajić, M., Čakić, S.,& Leković, V.. (2015). Clinical application of autologous fibroblast cell culture in gingival recession treatment. in Journal of Periodontal Research
Wiley, Hoboken., 50(3), 363-370.
https://doi.org/10.1111/jre.12215

Milinković I, Aleksić Z, Janković S, Popović O, Bajić M, Čakić S, Leković V. Clinical application of autologous fibroblast cell culture in gingival recession treatment. in Journal of Periodontal Research. 2015;50(3):363-370.
doi:10.1111/jre.12215 .

Milinković, Iva, Aleksić, Zoran, Janković, Saša, Popović, O., Bajić, Miljan, Čakić, Saša, Leković, Vojislav, "Clinical application of autologous fibroblast cell culture in gingival recession treatment" in Journal of Periodontal Research, 50, no. 3 (2015):363-370,
https://doi.org/10.1111/jre.12215 . .

TY  - JOUR
AU  - Perunović, Neda
AU  - Rakić, Mia
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Struillou, Xavier
AU  - Čakić, Saša
AU  - Puletić, Miljan
AU  - Leković, Vojislav
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2058
AB  - The objective of this pilot study was to investigate the potential role of-1562 C>T single nucleotide polymorphism (SNP) in the promoter region of the matrix metalloproteinase-9 (MMP-9) gene as a risk modulator in the development of multiple gingival recessions (MGRs) in young adults in the Serbian population. The study sample comprised 161 systemically healthy people: 60 with MGRs and 101 controls with healthy periodontal tissues. Genotyping was done using polymerase chain reaction/restriction fragment length polymorphism approach on DNA obtained from buccal swabs. Clinical measurements included vertical recession depth (VRD), clinical attachment level (CAL), keratinized gingival width (KGW), visible plaque index (PI), and bleeding on probing (BOP). Heterozygotes (CT) were significantly more frequent in the MGRs group than in the control group (P = .005) and carriers of the T allele had an approximately threefold increase of MGRs risk. Patients with the CT genotype exhibited significantly higher values of VRD and CAL and significantly lower values of KGW than patients with the wildtype genotype. Associations among different genotypes and periodontal biotypes in the MGRs group remained insignificant because all participants exhibited thin biotype. The 1562 C>T SNP in the promoter region of MMP-9 appears to be a risk factor for MGR development and a potential predictor of more severe clinical phenotype.
PB  - Quintessence Publishing Co. Inc.
T2  - International Journal of Periodontics & Restorative Dentistry
T1  - MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions
VL  - 35
IS  - 2
SP  - 263
EP  - 269
DO  - 10.11607/prd.2087
ER  - 

@article{
author = "Perunović, Neda and Rakić, Mia and Janković, Saša and Aleksić, Zoran and Struillou, Xavier and Čakić, Saša and Puletić, Miljan and Leković, Vojislav and Milašin, Jelena",
year = "2015",
abstract = "The objective of this pilot study was to investigate the potential role of-1562 C>T single nucleotide polymorphism (SNP) in the promoter region of the matrix metalloproteinase-9 (MMP-9) gene as a risk modulator in the development of multiple gingival recessions (MGRs) in young adults in the Serbian population. The study sample comprised 161 systemically healthy people: 60 with MGRs and 101 controls with healthy periodontal tissues. Genotyping was done using polymerase chain reaction/restriction fragment length polymorphism approach on DNA obtained from buccal swabs. Clinical measurements included vertical recession depth (VRD), clinical attachment level (CAL), keratinized gingival width (KGW), visible plaque index (PI), and bleeding on probing (BOP). Heterozygotes (CT) were significantly more frequent in the MGRs group than in the control group (P = .005) and carriers of the T allele had an approximately threefold increase of MGRs risk. Patients with the CT genotype exhibited significantly higher values of VRD and CAL and significantly lower values of KGW than patients with the wildtype genotype. Associations among different genotypes and periodontal biotypes in the MGRs group remained insignificant because all participants exhibited thin biotype. The 1562 C>T SNP in the promoter region of MMP-9 appears to be a risk factor for MGR development and a potential predictor of more severe clinical phenotype.",
publisher = "Quintessence Publishing Co. Inc.",
journal = "International Journal of Periodontics & Restorative Dentistry",
title = "MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions",
volume = "35",
number = "2",
pages = "263-269",
doi = "10.11607/prd.2087"
}

Perunović, N., Rakić, M., Janković, S., Aleksić, Z., Struillou, X., Čakić, S., Puletić, M., Leković, V.,& Milašin, J.. (2015). MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions. in International Journal of Periodontics & Restorative Dentistry
Quintessence Publishing Co. Inc.., 35(2), 263-269.
https://doi.org/10.11607/prd.2087

Perunović N, Rakić M, Janković S, Aleksić Z, Struillou X, Čakić S, Puletić M, Leković V, Milašin J. MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions. in International Journal of Periodontics & Restorative Dentistry. 2015;35(2):263-269.
doi:10.11607/prd.2087 .

Perunović, Neda, Rakić, Mia, Janković, Saša, Aleksić, Zoran, Struillou, Xavier, Čakić, Saša, Puletić, Miljan, Leković, Vojislav, Milašin, Jelena, "MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions" in International Journal of Periodontics & Restorative Dentistry, 35, no. 2 (2015):263-269,
https://doi.org/10.11607/prd.2087 . .

TY  - JOUR
AU  - Daković, Dragana
AU  - Mileusnić, Ivan
AU  - Hajduković, Zoran
AU  - Čakić, Saša
AU  - Hadži-Mihajlović, Miloš
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2025
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Gingivitis and periodontitis in children and adolescents suffering from type 1 diabetes mellitus
T1  - Gingivitis i parodontopatija kod dece i adolescenata obolelih od dijabetesa melitusa tipa 1
VL  - 72
IS  - 3
SP  - 265
EP  - 273
DO  - 10.2298/vsp131212050d
ER  - 

@article{
author = "Daković, Dragana and Mileusnić, Ivan and Hajduković, Zoran and Čakić, Saša and Hadži-Mihajlović, Miloš",
year = "2015",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Gingivitis and periodontitis in children and adolescents suffering from type 1 diabetes mellitus, Gingivitis i parodontopatija kod dece i adolescenata obolelih od dijabetesa melitusa tipa 1",
volume = "72",
number = "3",
pages = "265-273",
doi = "10.2298/vsp131212050d"
}

Daković, D., Mileusnić, I., Hajduković, Z., Čakić, S.,& Hadži-Mihajlović, M.. (2015). Gingivitis and periodontitis in children and adolescents suffering from type 1 diabetes mellitus. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(3), 265-273.
https://doi.org/10.2298/vsp131212050d

Daković D, Mileusnić I, Hajduković Z, Čakić S, Hadži-Mihajlović M. Gingivitis and periodontitis in children and adolescents suffering from type 1 diabetes mellitus. in Vojnosanitetski pregled. 2015;72(3):265-273.
doi:10.2298/vsp131212050d .

Daković, Dragana, Mileusnić, Ivan, Hajduković, Zoran, Čakić, Saša, Hadži-Mihajlović, Miloš, "Gingivitis and periodontitis in children and adolescents suffering from type 1 diabetes mellitus" in Vojnosanitetski pregled, 72, no. 3 (2015):265-273,
https://doi.org/10.2298/vsp131212050d . .

TY  - JOUR
AU  - Bajić, Miljan
AU  - Janković, Saša
AU  - Milinković, Iva
AU  - Čakić, Saša
AU  - Perunović, Neda
AU  - Novaković, Nada
AU  - Puletić, Miljan
AU  - Aleksić, Zoran
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1918
AB  - Introduction Gingival recession is a displacement of gingival margin apically to cement-enamel junction. Objective The aim of this study was to compare the results achieved with two different surgical procedures used in gingival recession treatment. Methods Ten patients with bilateral buccal recession on maxillary canines or premolars were included in the study. Professional teeth cleaning was performed before surgery. Recession on the experimental side was treated with connective tissue graft in combination with coronally advanced, split thickness flap (tunnel technique). Control side recession was treated with connective tissue graft in combination with trapezoidal coronally advanced, full thickness flap. Coin toss was used for side decision. The following parameters were evaluated before surgery and 6 months post-op: Vertical Recession Dimension, Clinical Attachment Level, Apico-coronal width of the keratinized tissue, Healing index (Laundry), RES index, and Patient evaluation of esthetic results. Student's t-test was used for statistical analysis. Results Six months after surgery, mean root coverage was 91.5±14.1% and 90.1±14.6% on the experimental and on the control side, respectively. RES index, Healing index (Laundry) and Patient Subjective evaluation of esthetic results showed significantly better results (p≤0.05). Conclusion Both surgical procedures produce highly successful clinical results based on evaluated parameters, but this tunnel technique provides significantly better esthetic results.
AB  - Uvod Gingivalna recesija, koja nastaje kao posledica morfoloških nepravilnosti u mukogingivalnom kompleksu, loše utiče na nastanak i prognozu parodontopatije i odlikuje se nezadovoljavajućom estetikom. Cilj rada Cilj ove studije bio je da se uporede rezultati dobijeni primenom dveju različitih hirurških tehnika u lečenju gingivalnih recesija. Metode rada U studiju je uključeno 10 pacijenata Klinike za parodontologiju i oralnu medicinu Stomatološkog fakulteta Univerziteta u Beogradu. Osnovni kriterijum za uključivanje u studiju bilo je postojanje obostranih gingivalnih recesija I ili II klase prema klasifikaciji Milera (Miller) na gornjim očnjacima ili premolarima. Izvođenje studije odobrio je Etički odbor Stomatološkog fakulteta. Ispitanici su podvrgnuti hirurškom lečenju, obostrano, primenom metoda podeljenih usta. Jedna strana tretirana je primenom transplantata vezivnog tkiva tunel- tehnikom (eksperimentalna tehnika), a druga konvencionalnom tehnikom (kontrolna tehnika). Posmatrani klinički parametri - vertikalna dimenzija gingivalne recesije, nivo pripojnog epitela i širina keratinizovane gingive - zabeleženi su pre operacije i šest meseci nakon hirurškog lečenja. Zarastanje u ranoj postoperacionoj fazi procenjivano je na osnovu vrednosti indeksa tkivnog zarastanja. Objektivna procena estetskog ishoda terapije vršena je pomoću indeksa prekrivenosti korena zuba. Rezultati Šest meseci nakon intervencije primenom eksperimentalne tehnike ostvarena je prekrivenost korena od 91,5±14,1%, dok je primenom kontrolne tehnike ostvarena pokrivenost korena od 90,1±14,6%. Parametri za objektivnu procenu postignutih estetskih rezultata i indeksa zarastanja rane pokazali su statistički značajno bolje rezultate ostvarene primenom eksperimentalne tehnike. Zaključak Obe procedure uspešne su u lečenju gingivalne recesije i daju predvidljive rezultate, ali se primenom tunel- tehnike mogu očekivati bolji estetski rezultati.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Utilization of two different surgical techniques in gingival recession treatment: A comparative study
T1  - Komparativna analiza primene dveju tehnika transplantata vezivnog tkiva u lečenju recesija gingive
VL  - 142
IS  - 3-4
SP  - 155
EP  - 163
DO  - 10.2298/SARH1404155B
ER  - 

@article{
author = "Bajić, Miljan and Janković, Saša and Milinković, Iva and Čakić, Saša and Perunović, Neda and Novaković, Nada and Puletić, Miljan and Aleksić, Zoran",
year = "2014",
abstract = "Introduction Gingival recession is a displacement of gingival margin apically to cement-enamel junction. Objective The aim of this study was to compare the results achieved with two different surgical procedures used in gingival recession treatment. Methods Ten patients with bilateral buccal recession on maxillary canines or premolars were included in the study. Professional teeth cleaning was performed before surgery. Recession on the experimental side was treated with connective tissue graft in combination with coronally advanced, split thickness flap (tunnel technique). Control side recession was treated with connective tissue graft in combination with trapezoidal coronally advanced, full thickness flap. Coin toss was used for side decision. The following parameters were evaluated before surgery and 6 months post-op: Vertical Recession Dimension, Clinical Attachment Level, Apico-coronal width of the keratinized tissue, Healing index (Laundry), RES index, and Patient evaluation of esthetic results. Student's t-test was used for statistical analysis. Results Six months after surgery, mean root coverage was 91.5±14.1% and 90.1±14.6% on the experimental and on the control side, respectively. RES index, Healing index (Laundry) and Patient Subjective evaluation of esthetic results showed significantly better results (p≤0.05). Conclusion Both surgical procedures produce highly successful clinical results based on evaluated parameters, but this tunnel technique provides significantly better esthetic results., Uvod Gingivalna recesija, koja nastaje kao posledica morfoloških nepravilnosti u mukogingivalnom kompleksu, loše utiče na nastanak i prognozu parodontopatije i odlikuje se nezadovoljavajućom estetikom. Cilj rada Cilj ove studije bio je da se uporede rezultati dobijeni primenom dveju različitih hirurških tehnika u lečenju gingivalnih recesija. Metode rada U studiju je uključeno 10 pacijenata Klinike za parodontologiju i oralnu medicinu Stomatološkog fakulteta Univerziteta u Beogradu. Osnovni kriterijum za uključivanje u studiju bilo je postojanje obostranih gingivalnih recesija I ili II klase prema klasifikaciji Milera (Miller) na gornjim očnjacima ili premolarima. Izvođenje studije odobrio je Etički odbor Stomatološkog fakulteta. Ispitanici su podvrgnuti hirurškom lečenju, obostrano, primenom metoda podeljenih usta. Jedna strana tretirana je primenom transplantata vezivnog tkiva tunel- tehnikom (eksperimentalna tehnika), a druga konvencionalnom tehnikom (kontrolna tehnika). Posmatrani klinički parametri - vertikalna dimenzija gingivalne recesije, nivo pripojnog epitela i širina keratinizovane gingive - zabeleženi su pre operacije i šest meseci nakon hirurškog lečenja. Zarastanje u ranoj postoperacionoj fazi procenjivano je na osnovu vrednosti indeksa tkivnog zarastanja. Objektivna procena estetskog ishoda terapije vršena je pomoću indeksa prekrivenosti korena zuba. Rezultati Šest meseci nakon intervencije primenom eksperimentalne tehnike ostvarena je prekrivenost korena od 91,5±14,1%, dok je primenom kontrolne tehnike ostvarena pokrivenost korena od 90,1±14,6%. Parametri za objektivnu procenu postignutih estetskih rezultata i indeksa zarastanja rane pokazali su statistički značajno bolje rezultate ostvarene primenom eksperimentalne tehnike. Zaključak Obe procedure uspešne su u lečenju gingivalne recesije i daju predvidljive rezultate, ali se primenom tunel- tehnike mogu očekivati bolji estetski rezultati.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Utilization of two different surgical techniques in gingival recession treatment: A comparative study, Komparativna analiza primene dveju tehnika transplantata vezivnog tkiva u lečenju recesija gingive",
volume = "142",
number = "3-4",
pages = "155-163",
doi = "10.2298/SARH1404155B"
}

Bajić, M., Janković, S., Milinković, I., Čakić, S., Perunović, N., Novaković, N., Puletić, M.,& Aleksić, Z.. (2014). Utilization of two different surgical techniques in gingival recession treatment: A comparative study. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(3-4), 155-163.
https://doi.org/10.2298/SARH1404155B

Bajić M, Janković S, Milinković I, Čakić S, Perunović N, Novaković N, Puletić M, Aleksić Z. Utilization of two different surgical techniques in gingival recession treatment: A comparative study. in Srpski arhiv za celokupno lekarstvo. 2014;142(3-4):155-163.
doi:10.2298/SARH1404155B .

Bajić, Miljan, Janković, Saša, Milinković, Iva, Čakić, Saša, Perunović, Neda, Novaković, Nada, Puletić, Miljan, Aleksić, Zoran, "Utilization of two different surgical techniques in gingival recession treatment: A comparative study" in Srpski arhiv za celokupno lekarstvo, 142, no. 3-4 (2014):155-163,
https://doi.org/10.2298/SARH1404155B . .

TY  - JOUR
AU  - Novaković, N.
AU  - Todorović, Tatjana
AU  - Rakić, Mia
AU  - Milinković, Iva
AU  - Dožić, Ivan
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Čakić, Saša
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1880
AB  - Background and objective: One of the major pathologic patterns in periodontitis represents an imbalance among the production of free radicals and local antioxidants resulting in periodontal tissue destruction. The objective of the study was to investigate the influence of non-surgical periodontal treatment on salivary antioxidants and to evaluate their capacity as biomarkers reflecting periodontal tissue condition and therapy outcome. Material and Methods: Sixty-three systemically healthy non-smokers, including 21 periodontally healthy subjects (HC) and 42 patients with current chronic periodontitis fulfilled the inclusion criteria. Half of the patients received scaling and root planing (SRP) and the other half received only oral hygiene instructions. Full mouth clinical measurements, including gingival index (GI), plaque index (PI), periodontal pocket depth, clinical attachment level and saliva sampling were performed at baseline visit and 2 mo after treatment/baseline visit. Total antioxidant capacity (TAOC), albumins (ALB), uric acid (UA), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were evaluated in saliva samples using commercial kits. Results: All measured antioxidants were affected by treatment resulting in significant increase in TAOC (p  lt  0.005), ALB (p  lt  0.001), UA (p  lt  0.001) and GPX (p  lt  0.001) and decrease of SOD (p  lt  0.005) in response to SRP, where no differences were observed for any of parameters in the oral hygiene instructions group. Comparison of antioxidant levels between the HC and SRP group showed that before treatment ALB were significantly higher in HC when compared to the SRP group (p = 0.039), and GXP (p = 0.000) and SOD (p = 0.021) levels were significantly higher in the SRP group. Comparison of values after treatment showed that TAOC was significantly higher in the HC than in the SRP group (p = 0.001), but UA was, inversely, significantly higher in the SRP group (p = 0.034). All clinical parameters except clinical attachment level were significantly decreased after SRP and significant correlations were observed between SOD and GI (p = 0.017), SOD and PI (p = 0.011), GPX and GI (p = 0.003) and GPX and PI (p = 0.008). Conclusion: Non-surgical periodontal treatment affected salivary TAOC, ALB, UA, SOD and GPX; moreover, these biochemical parameters convincingly reflected periodontal status and tissue response on treatment.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Periodontal Research
T1  - Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome
VL  - 49
IS  - 1
SP  - 129
EP  - 136
DO  - 10.1111/jre.12088
ER  - 

@article{
author = "Novaković, N. and Todorović, Tatjana and Rakić, Mia and Milinković, Iva and Dožić, Ivan and Janković, Saša and Aleksić, Zoran and Čakić, Saša",
year = "2014",
abstract = "Background and objective: One of the major pathologic patterns in periodontitis represents an imbalance among the production of free radicals and local antioxidants resulting in periodontal tissue destruction. The objective of the study was to investigate the influence of non-surgical periodontal treatment on salivary antioxidants and to evaluate their capacity as biomarkers reflecting periodontal tissue condition and therapy outcome. Material and Methods: Sixty-three systemically healthy non-smokers, including 21 periodontally healthy subjects (HC) and 42 patients with current chronic periodontitis fulfilled the inclusion criteria. Half of the patients received scaling and root planing (SRP) and the other half received only oral hygiene instructions. Full mouth clinical measurements, including gingival index (GI), plaque index (PI), periodontal pocket depth, clinical attachment level and saliva sampling were performed at baseline visit and 2 mo after treatment/baseline visit. Total antioxidant capacity (TAOC), albumins (ALB), uric acid (UA), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were evaluated in saliva samples using commercial kits. Results: All measured antioxidants were affected by treatment resulting in significant increase in TAOC (p  lt  0.005), ALB (p  lt  0.001), UA (p  lt  0.001) and GPX (p  lt  0.001) and decrease of SOD (p  lt  0.005) in response to SRP, where no differences were observed for any of parameters in the oral hygiene instructions group. Comparison of antioxidant levels between the HC and SRP group showed that before treatment ALB were significantly higher in HC when compared to the SRP group (p = 0.039), and GXP (p = 0.000) and SOD (p = 0.021) levels were significantly higher in the SRP group. Comparison of values after treatment showed that TAOC was significantly higher in the HC than in the SRP group (p = 0.001), but UA was, inversely, significantly higher in the SRP group (p = 0.034). All clinical parameters except clinical attachment level were significantly decreased after SRP and significant correlations were observed between SOD and GI (p = 0.017), SOD and PI (p = 0.011), GPX and GI (p = 0.003) and GPX and PI (p = 0.008). Conclusion: Non-surgical periodontal treatment affected salivary TAOC, ALB, UA, SOD and GPX; moreover, these biochemical parameters convincingly reflected periodontal status and tissue response on treatment.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Periodontal Research",
title = "Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome",
volume = "49",
number = "1",
pages = "129-136",
doi = "10.1111/jre.12088"
}

Novaković, N., Todorović, T., Rakić, M., Milinković, I., Dožić, I., Janković, S., Aleksić, Z.,& Čakić, S.. (2014). Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome. in Journal of Periodontal Research
Wiley-Blackwell, Hoboken., 49(1), 129-136.
https://doi.org/10.1111/jre.12088

Novaković N, Todorović T, Rakić M, Milinković I, Dožić I, Janković S, Aleksić Z, Čakić S. Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome. in Journal of Periodontal Research. 2014;49(1):129-136.
doi:10.1111/jre.12088 .

Novaković, N., Todorović, Tatjana, Rakić, Mia, Milinković, Iva, Dožić, Ivan, Janković, Saša, Aleksić, Zoran, Čakić, Saša, "Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome" in Journal of Periodontal Research, 49, no. 1 (2014):129-136,
https://doi.org/10.1111/jre.12088 . .

TY  - JOUR
AU  - Petrović, Vanja
AU  - Pejčić, Nataša
AU  - Čakić, Saša
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1823
AB  - Background. Traumatic injuries of permanent teeth with incomplete root formation are frequent during childhood. Adequate therapy is important for the further destiny of teeth with damaged pulp. Objectives. To evaluate the effect of pulpotomy and high pulpotomy on the pulp and on root development, and the effect of platelet rich plasma (PRP) with hydroxyapatite (HAP) as a carrier and hydroxyapatite alone on apexogenesis. Material and Methods. The study included eight monkeys (Cercopithecus aethiops) in which high pulpotomies were performed on the mandibular lateral incisors and canines, and pulpotomies were performed on the mandibular central incisors and premolars. The materials used in the study were commercial HAP (Apatec (R), Stomygen) and PR? (prepared at the Torlak Institute of Immunology and Virology, Belgrade, Serbia). Histological and radiological evaluations were done six months after the treatment. Results. Considering the differences between HAP+PRP treated teeth in the pulpotomy group and teeth in the high pulpotomy group, two times more root growth retardation was observed in the high pulpotomy group. In the high pulpotomy group, root growth retardation was less common in HAP+PRP treated teeth (42.9%) than in HAP treated teeth (50%). In the pulpotomy group, retardation of root development was also less common in HAP+PRP treated teeth (25%) compared to HAP treated teeth (50%). There were differences between the pulpotomy and high pulpotomy groups, but without statistical significance. Conclusions. The application of endogenous growth factors in conjunction with the preservation of dental pulp vitality can result in a good outcome for pulp therapy of injured teeth, which means successfully completed apexogenesis
T2  - Advances in Clinical & Experimental Medicine
T1  - The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys
VL  - 22
IS  - 4
SP  - 469
EP  - 479
UR  - https://hdl.handle.net/21.15107/rcub_smile_1823
ER  - 

@article{
author = "Petrović, Vanja and Pejčić, Nataša and Čakić, Saša",
year = "2013",
abstract = "Background. Traumatic injuries of permanent teeth with incomplete root formation are frequent during childhood. Adequate therapy is important for the further destiny of teeth with damaged pulp. Objectives. To evaluate the effect of pulpotomy and high pulpotomy on the pulp and on root development, and the effect of platelet rich plasma (PRP) with hydroxyapatite (HAP) as a carrier and hydroxyapatite alone on apexogenesis. Material and Methods. The study included eight monkeys (Cercopithecus aethiops) in which high pulpotomies were performed on the mandibular lateral incisors and canines, and pulpotomies were performed on the mandibular central incisors and premolars. The materials used in the study were commercial HAP (Apatec (R), Stomygen) and PR? (prepared at the Torlak Institute of Immunology and Virology, Belgrade, Serbia). Histological and radiological evaluations were done six months after the treatment. Results. Considering the differences between HAP+PRP treated teeth in the pulpotomy group and teeth in the high pulpotomy group, two times more root growth retardation was observed in the high pulpotomy group. In the high pulpotomy group, root growth retardation was less common in HAP+PRP treated teeth (42.9%) than in HAP treated teeth (50%). In the pulpotomy group, retardation of root development was also less common in HAP+PRP treated teeth (25%) compared to HAP treated teeth (50%). There were differences between the pulpotomy and high pulpotomy groups, but without statistical significance. Conclusions. The application of endogenous growth factors in conjunction with the preservation of dental pulp vitality can result in a good outcome for pulp therapy of injured teeth, which means successfully completed apexogenesis",
journal = "Advances in Clinical & Experimental Medicine",
title = "The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys",
volume = "22",
number = "4",
pages = "469-479",
url = "https://hdl.handle.net/21.15107/rcub_smile_1823"
}

Petrović, V., Pejčić, N.,& Čakić, S.. (2013). The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys. in Advances in Clinical & Experimental Medicine, 22(4), 469-479.
https://hdl.handle.net/21.15107/rcub_smile_1823

Petrović V, Pejčić N, Čakić S. The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys. in Advances in Clinical & Experimental Medicine. 2013;22(4):469-479.
https://hdl.handle.net/21.15107/rcub_smile_1823 .

Petrović, Vanja, Pejčić, Nataša, Čakić, Saša, "The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys" in Advances in Clinical & Experimental Medicine, 22, no. 4 (2013):469-479,
https://hdl.handle.net/21.15107/rcub_smile_1823 .

TY  - JOUR
AU  - Novaković, Nada
AU  - Čakić, Saša
AU  - Todorović, Tatjana
AU  - Anđelski-Radičević, Biljana
AU  - Dožić, Ivan
AU  - Petrović, Vanja
AU  - Perunović, Neda
AU  - Špadijer-Gostović, Aleksandra
AU  - Kadović-Sretenović, Jana
AU  - Čolak, Emina
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1796
AB  - Introduction. Oxidative stress and antioxidants play an important role in the pathogenesis of inflammatory disease, including chronic periodontitis (CP). Saliva contains enzymatic (glutathione peroxidase - GPx, superoxide dismutase - SOD, etc.) and non-enzymatic (albumin - ALB, uric acid - UA, glutathione, etc.) antioxidants. Objective. The aims of this study were to investigate: a) level of SOD, GPx, UA, ALB and total antioxidative status (TAS) of saliva in CP patients before and after non-surgical treatment, and b) correlations between clinical periodontal parameters and levels of salivary antioxidants. Methods. Saliva was collected from 21 CP patients before and after non-surgical treatment. The condition of periodontium was assessed by plaque index, gingival index, bleeding on probing, probing depth and clinical attachment loss. Level of investigated antioxidants (except GPx) and TAS was determined using colorimetric method and commercial kits. GPx activity was determined using UV method and commercial kits. Results. After the treatment significant increase of UA, ALB, Gpx, TAS was detected (p lt 0.01) and decrease of SOD activity (p>0.05). A significant correlation was observed between GPx and PI (r=0.575, p=0.008), SOD and GI (r=0.525, p=0.017) before therapy, and SOD and bleeding on probing (BP) (r=0.59, p=0.006), TAS and BP (r=0.453, p=0.045) after therapy. Conclusion. These data suggest that levels of salivary antioxidants generally increase after non-surgical periodontal treatment. Correlation between some clinical periodontal parameters and level of salivary antioxidants was found.
AB  - Uvod. Oksidativni stres i antioksidansi igraju važnu ulogu u patogenezi zapaljenjskih oboljenja, uključujući i hroničnu parodontopatiju. Pljuvačka sadrži enzimske antioksidanse, kao što su glutation-peroksidaza (GPx) i superoksid-dismutaza (SOD), i neenzimske antioksidanse, poput albumina (ALB), mokraćne kiseline (UA), glutationa itd. Cilj rada. Cilj istraživanja bio je da se ispitaju nivoi SOD, GPx, UA i ALB i utvrdi ukupan antioksidantni status pljuvačke (TAS) kod osoba s hroničnom parodontopatijom pre i posle kauzalne terapije, te ustanove korelacije između kliničkih pokazatelja stanja parodoncijuma i nivoa antioksidansa u pljuvački. Metode rada. Pljuvačka je sakupljena od 21 pacijenta s hroničnom parodontopatijom pre i posle kauzalne terapije. Stanje parodoncijuma je procenjivano pomoću: plak-indeksa (PI), gingivalnog indeksa (GI), indeksa krvarenja gingive (BP), dubine parodontalnog džepa i nivoa pripojnog epitela. Nivo ispitivanih antioksidansa (osim GPx) i TAS određivan je pomoću kolorimetrijske metode i komercijalnih reagensa. GPx je određivan primenom UV metode i komercijalnih reagensa. Rezultati. Nakon terapije ustanovljeni su značajno povećanje koncentracije UA, GPx i TAS (p lt 0,01) i smanjenje aktivnosti SOD (p>0,05). Primećena je i značajna korelacija između GPx i PI (r=0,575; p=0,008), te SOD i GI (r=0,525; p=0,017) pre terapije, odnosno SOD i BP (r=0,59; p=0,006), kao i TAS i BP (r=0,453; p=0,045) posle nje. Zaključak. Dobijeni nalazi pokazuju da se nivoi antioksidansa u pljuvački povećavaju nakon kauzalne terapije parodontopatije. Uočene su pozitivne korelacije između kliničkih pokazatelja stanja parodoncijuma i ispitivanih koncentracija antioksidansa u pljuvački.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Antioxidative status of saliva before and after non-surgical periodontal treatment
T1  - Antioksidantni status pljuvačke pre i posle kauzalne terapije parodontopatije
VL  - 141
IS  - 3-4
SP  - 163
EP  - 168
DO  - 10.2298/SARH1304163N
ER  - 

@article{
author = "Novaković, Nada and Čakić, Saša and Todorović, Tatjana and Anđelski-Radičević, Biljana and Dožić, Ivan and Petrović, Vanja and Perunović, Neda and Špadijer-Gostović, Aleksandra and Kadović-Sretenović, Jana and Čolak, Emina",
year = "2013",
abstract = "Introduction. Oxidative stress and antioxidants play an important role in the pathogenesis of inflammatory disease, including chronic periodontitis (CP). Saliva contains enzymatic (glutathione peroxidase - GPx, superoxide dismutase - SOD, etc.) and non-enzymatic (albumin - ALB, uric acid - UA, glutathione, etc.) antioxidants. Objective. The aims of this study were to investigate: a) level of SOD, GPx, UA, ALB and total antioxidative status (TAS) of saliva in CP patients before and after non-surgical treatment, and b) correlations between clinical periodontal parameters and levels of salivary antioxidants. Methods. Saliva was collected from 21 CP patients before and after non-surgical treatment. The condition of periodontium was assessed by plaque index, gingival index, bleeding on probing, probing depth and clinical attachment loss. Level of investigated antioxidants (except GPx) and TAS was determined using colorimetric method and commercial kits. GPx activity was determined using UV method and commercial kits. Results. After the treatment significant increase of UA, ALB, Gpx, TAS was detected (p lt 0.01) and decrease of SOD activity (p>0.05). A significant correlation was observed between GPx and PI (r=0.575, p=0.008), SOD and GI (r=0.525, p=0.017) before therapy, and SOD and bleeding on probing (BP) (r=0.59, p=0.006), TAS and BP (r=0.453, p=0.045) after therapy. Conclusion. These data suggest that levels of salivary antioxidants generally increase after non-surgical periodontal treatment. Correlation between some clinical periodontal parameters and level of salivary antioxidants was found., Uvod. Oksidativni stres i antioksidansi igraju važnu ulogu u patogenezi zapaljenjskih oboljenja, uključujući i hroničnu parodontopatiju. Pljuvačka sadrži enzimske antioksidanse, kao što su glutation-peroksidaza (GPx) i superoksid-dismutaza (SOD), i neenzimske antioksidanse, poput albumina (ALB), mokraćne kiseline (UA), glutationa itd. Cilj rada. Cilj istraživanja bio je da se ispitaju nivoi SOD, GPx, UA i ALB i utvrdi ukupan antioksidantni status pljuvačke (TAS) kod osoba s hroničnom parodontopatijom pre i posle kauzalne terapije, te ustanove korelacije između kliničkih pokazatelja stanja parodoncijuma i nivoa antioksidansa u pljuvački. Metode rada. Pljuvačka je sakupljena od 21 pacijenta s hroničnom parodontopatijom pre i posle kauzalne terapije. Stanje parodoncijuma je procenjivano pomoću: plak-indeksa (PI), gingivalnog indeksa (GI), indeksa krvarenja gingive (BP), dubine parodontalnog džepa i nivoa pripojnog epitela. Nivo ispitivanih antioksidansa (osim GPx) i TAS određivan je pomoću kolorimetrijske metode i komercijalnih reagensa. GPx je određivan primenom UV metode i komercijalnih reagensa. Rezultati. Nakon terapije ustanovljeni su značajno povećanje koncentracije UA, GPx i TAS (p lt 0,01) i smanjenje aktivnosti SOD (p>0,05). Primećena je i značajna korelacija između GPx i PI (r=0,575; p=0,008), te SOD i GI (r=0,525; p=0,017) pre terapije, odnosno SOD i BP (r=0,59; p=0,006), kao i TAS i BP (r=0,453; p=0,045) posle nje. Zaključak. Dobijeni nalazi pokazuju da se nivoi antioksidansa u pljuvački povećavaju nakon kauzalne terapije parodontopatije. Uočene su pozitivne korelacije između kliničkih pokazatelja stanja parodoncijuma i ispitivanih koncentracija antioksidansa u pljuvački.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Antioxidative status of saliva before and after non-surgical periodontal treatment, Antioksidantni status pljuvačke pre i posle kauzalne terapije parodontopatije",
volume = "141",
number = "3-4",
pages = "163-168",
doi = "10.2298/SARH1304163N"
}

Novaković, N., Čakić, S., Todorović, T., Anđelski-Radičević, B., Dožić, I., Petrović, V., Perunović, N., Špadijer-Gostović, A., Kadović-Sretenović, J.,& Čolak, E.. (2013). Antioxidative status of saliva before and after non-surgical periodontal treatment. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 141(3-4), 163-168.
https://doi.org/10.2298/SARH1304163N

Novaković N, Čakić S, Todorović T, Anđelski-Radičević B, Dožić I, Petrović V, Perunović N, Špadijer-Gostović A, Kadović-Sretenović J, Čolak E. Antioxidative status of saliva before and after non-surgical periodontal treatment. in Srpski arhiv za celokupno lekarstvo. 2013;141(3-4):163-168.
doi:10.2298/SARH1304163N .

Novaković, Nada, Čakić, Saša, Todorović, Tatjana, Anđelski-Radičević, Biljana, Dožić, Ivan, Petrović, Vanja, Perunović, Neda, Špadijer-Gostović, Aleksandra, Kadović-Sretenović, Jana, Čolak, Emina, "Antioxidative status of saliva before and after non-surgical periodontal treatment" in Srpski arhiv za celokupno lekarstvo, 141, no. 3-4 (2013):163-168,
https://doi.org/10.2298/SARH1304163N . .

TY  - JOUR
AU  - Daković, Dragana
AU  - Čolić, Miodrag
AU  - Čakić, Saša
AU  - Mileusnić, Ivan
AU  - Hajduković, Zoran
AU  - Stamatović, Novak
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1852
AB  - Objective: The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type I diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established Methods: Twenty children and adolescents with Type I DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. Results: The Salivary IL-8 level was statistically significantly (p lt 0.005) elevated in subjects with Type 1 DM (474.47 +/- 716.76) compared to non-diabetic control group (101.99 +/- 68.32). There was no difference (p>0.05) in the salivary IL-8 level when subjects with Type I DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type I DM was correlated with the clinical parameters, no statistical significance was found Conclusion: An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.
PB  - Journal Pedodontics Inc, Birmingham
T2  - Journal of Clinical Pediatric Dentistry
T1  - Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus
VL  - 37
IS  - 4
SP  - 377
EP  - 380
DO  - 10.17796/jcpd.37.4.l135531h4542gj66
ER  - 

@article{
author = "Daković, Dragana and Čolić, Miodrag and Čakić, Saša and Mileusnić, Ivan and Hajduković, Zoran and Stamatović, Novak",
year = "2013",
abstract = "Objective: The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type I diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established Methods: Twenty children and adolescents with Type I DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. Results: The Salivary IL-8 level was statistically significantly (p lt 0.005) elevated in subjects with Type 1 DM (474.47 +/- 716.76) compared to non-diabetic control group (101.99 +/- 68.32). There was no difference (p>0.05) in the salivary IL-8 level when subjects with Type I DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type I DM was correlated with the clinical parameters, no statistical significance was found Conclusion: An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.",
publisher = "Journal Pedodontics Inc, Birmingham",
journal = "Journal of Clinical Pediatric Dentistry",
title = "Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus",
volume = "37",
number = "4",
pages = "377-380",
doi = "10.17796/jcpd.37.4.l135531h4542gj66"
}

Daković, D., Čolić, M., Čakić, S., Mileusnić, I., Hajduković, Z.,& Stamatović, N.. (2013). Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus. in Journal of Clinical Pediatric Dentistry
Journal Pedodontics Inc, Birmingham., 37(4), 377-380.
https://doi.org/10.17796/jcpd.37.4.l135531h4542gj66

Daković D, Čolić M, Čakić S, Mileusnić I, Hajduković Z, Stamatović N. Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus. in Journal of Clinical Pediatric Dentistry. 2013;37(4):377-380.
doi:10.17796/jcpd.37.4.l135531h4542gj66 .

Daković, Dragana, Čolić, Miodrag, Čakić, Saša, Mileusnić, Ivan, Hajduković, Zoran, Stamatović, Novak, "Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus" in Journal of Clinical Pediatric Dentistry, 37, no. 4 (2013):377-380,
https://doi.org/10.17796/jcpd.37.4.l135531h4542gj66 . .

TY  - JOUR
AU  - Besu, Irina
AU  - Janković, Ljiljana
AU  - Konić-Ristić, Aleksandra
AU  - Rasković, Sanvila
AU  - Besu, Valeri
AU  - Đurić, Milanko
AU  - Čakić, Saša
AU  - Magdu, Ileana Ursu
AU  - Juranić, Zorica
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1817
AB  - Background Recurrent aphthous ulcerations (RAU), or recurrent aphthous stomatitis, is recognized as one of the most common oral mucosal diseases worldwide. It was noted some connection between immunity to cow's milk proteins (CMP) and oral diseases. The goal of this study was to determine the prevalence of the increased levels of serum antibodies to specific cow's milk proteins (SCMP), constituents of cheese or of whey, by enzyme-linked immunosorbent assay (ELISA) test, in subjects who have RAU. Methods Fifty subjects with RAU and 50 healthy people, as controls (C), were included in this research. Levels of serum IgA, IgG, and IgE antibodies to SCMP were determined by ELISA. The statistical analysis of data was performed by Wilcoxon rank sum test with continuity correction. Results The levels of serum anti-SCMP IgA, IgG, and IgE antibodies were significantly higher in subjects with RAU in comparison with controls (P  lt  0.005). Conclusions These results indicate the strong association between high levels of serum anti-SCMP IgA, IgG, and IgE antibodies, especially to caseins: a-, beta-, and ?-casein from cow's milk and clinical manifestations of RAU. Serum immunity to the whey proteins in subjects with RAU was not in so high percentage expressed.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Oral Pathology & Medicine
T1  - The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers
VL  - 42
IS  - 1
SP  - 82
EP  - 88
DO  - 10.1111/j.1600-0714.2012.01204.x
ER  - 

@article{
author = "Besu, Irina and Janković, Ljiljana and Konić-Ristić, Aleksandra and Rasković, Sanvila and Besu, Valeri and Đurić, Milanko and Čakić, Saša and Magdu, Ileana Ursu and Juranić, Zorica",
year = "2013",
abstract = "Background Recurrent aphthous ulcerations (RAU), or recurrent aphthous stomatitis, is recognized as one of the most common oral mucosal diseases worldwide. It was noted some connection between immunity to cow's milk proteins (CMP) and oral diseases. The goal of this study was to determine the prevalence of the increased levels of serum antibodies to specific cow's milk proteins (SCMP), constituents of cheese or of whey, by enzyme-linked immunosorbent assay (ELISA) test, in subjects who have RAU. Methods Fifty subjects with RAU and 50 healthy people, as controls (C), were included in this research. Levels of serum IgA, IgG, and IgE antibodies to SCMP were determined by ELISA. The statistical analysis of data was performed by Wilcoxon rank sum test with continuity correction. Results The levels of serum anti-SCMP IgA, IgG, and IgE antibodies were significantly higher in subjects with RAU in comparison with controls (P  lt  0.005). Conclusions These results indicate the strong association between high levels of serum anti-SCMP IgA, IgG, and IgE antibodies, especially to caseins: a-, beta-, and ?-casein from cow's milk and clinical manifestations of RAU. Serum immunity to the whey proteins in subjects with RAU was not in so high percentage expressed.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Oral Pathology & Medicine",
title = "The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers",
volume = "42",
number = "1",
pages = "82-88",
doi = "10.1111/j.1600-0714.2012.01204.x"
}

Besu, I., Janković, L., Konić-Ristić, A., Rasković, S., Besu, V., Đurić, M., Čakić, S., Magdu, I. U.,& Juranić, Z.. (2013). The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers. in Journal of Oral Pathology & Medicine
Wiley-Blackwell, Hoboken., 42(1), 82-88.
https://doi.org/10.1111/j.1600-0714.2012.01204.x

Besu I, Janković L, Konić-Ristić A, Rasković S, Besu V, Đurić M, Čakić S, Magdu IU, Juranić Z. The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers. in Journal of Oral Pathology & Medicine. 2013;42(1):82-88.
doi:10.1111/j.1600-0714.2012.01204.x .

Besu, Irina, Janković, Ljiljana, Konić-Ristić, Aleksandra, Rasković, Sanvila, Besu, Valeri, Đurić, Milanko, Čakić, Saša, Magdu, Ileana Ursu, Juranić, Zorica, "The role of specific cow's milk proteins in the etiology of recurrent aphthous ulcers" in Journal of Oral Pathology & Medicine, 42, no. 1 (2013):82-88,
https://doi.org/10.1111/j.1600-0714.2012.01204.x . .

TY  - JOUR
AU  - Hadži-Mihailović, Miloš
AU  - Čakić, Saša
AU  - Janković, Saša
AU  - Raybaud, Helene
AU  - Nedeljković, Nenad
AU  - Janković, Ljiljana
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1748
AB  - Purpose: The monoclonal antibody Ki-67 detects a nuclear antigen that is present only in proliferating cells. This is of particular interest for the analysis of the proliferation rates of malignant tumors. The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of expression of Ki-67 in healthy individuals (HI), patients with OLP and patients with squamous cell carcinoma (SCC), and to see for any potential interdependence between Ki-67 expression and different clinical and histopathological parameters in OLP. Methods: Immunohistochemistry for Ki-67 was carried out using an avidin-biotin peroxidase complex method. Results: Ki-67 was more expressed in keratinocytes and lymphocytes of OLP patients compared with HI, but less compared with patients with SCC. Keratinocytes and lymphocytes stained with Ki-67 in OLP patients were significantly higher in males, and in OLP specimens showed less developed civatte bodies (CB) and thickening of the basal membrane (TBM). Conclusion: Ki-67 may not serve as prognostic biomarker in oral cancer development from the initially diagnosed OLP, but it could help selecting patients with higher need of follow up for prevention of malignancy.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Ki-67 expression in oral lichen planus
VL  - 17
IS  - 1
SP  - 132
EP  - 137
UR  - https://hdl.handle.net/21.15107/rcub_smile_1748
ER  - 

@article{
author = "Hadži-Mihailović, Miloš and Čakić, Saša and Janković, Saša and Raybaud, Helene and Nedeljković, Nenad and Janković, Ljiljana",
year = "2012",
abstract = "Purpose: The monoclonal antibody Ki-67 detects a nuclear antigen that is present only in proliferating cells. This is of particular interest for the analysis of the proliferation rates of malignant tumors. The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of expression of Ki-67 in healthy individuals (HI), patients with OLP and patients with squamous cell carcinoma (SCC), and to see for any potential interdependence between Ki-67 expression and different clinical and histopathological parameters in OLP. Methods: Immunohistochemistry for Ki-67 was carried out using an avidin-biotin peroxidase complex method. Results: Ki-67 was more expressed in keratinocytes and lymphocytes of OLP patients compared with HI, but less compared with patients with SCC. Keratinocytes and lymphocytes stained with Ki-67 in OLP patients were significantly higher in males, and in OLP specimens showed less developed civatte bodies (CB) and thickening of the basal membrane (TBM). Conclusion: Ki-67 may not serve as prognostic biomarker in oral cancer development from the initially diagnosed OLP, but it could help selecting patients with higher need of follow up for prevention of malignancy.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Ki-67 expression in oral lichen planus",
volume = "17",
number = "1",
pages = "132-137",
url = "https://hdl.handle.net/21.15107/rcub_smile_1748"
}

Hadži-Mihailović, M., Čakić, S., Janković, S., Raybaud, H., Nedeljković, N.,& Janković, L.. (2012). Ki-67 expression in oral lichen planus. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 17(1), 132-137.
https://hdl.handle.net/21.15107/rcub_smile_1748

Hadži-Mihailović M, Čakić S, Janković S, Raybaud H, Nedeljković N, Janković L. Ki-67 expression in oral lichen planus. in Journal of BUON. 2012;17(1):132-137.
https://hdl.handle.net/21.15107/rcub_smile_1748 .

Hadži-Mihailović, Miloš, Čakić, Saša, Janković, Saša, Raybaud, Helene, Nedeljković, Nenad, Janković, Ljiljana, "Ki-67 expression in oral lichen planus" in Journal of BUON, 17, no. 1 (2012):132-137,
https://hdl.handle.net/21.15107/rcub_smile_1748 .

TY  - JOUR
AU  - Cicmil, Smiljka
AU  - Stojanović, Nikola
AU  - Krunić, Jelena
AU  - Vukotić, Olivera
AU  - Čakić, Saša
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1548
AB  - Introduction. It has been known that periodontitis is one of the most common oral diseases in patients having diabetes mellitus (DM). The aim of this study was to examine the influence of glycosylated hemoglobin (HbA1c) level and the level of oral hygiene on periodontal status of patients suffering from DM. Material and Methods. The research included 50 people with type 2 DM randomly selected. Based on values of HbA1c, patients were divided into two groups: well controlled DM (HbA1c≤8.5%) and poorly controlled DM (HbA1c>8.5%). Patients with poorly and well controlled DM were further grouped into subgroups depending on the level of oral hygiene. For each patient, during the clinical examination, periodontal parameters were determined: plaque index (PI), sulcus bleeding index (SBI), the level of junctional epithelium (LJE) and periodontal pocket depth (PPD). Results. The results showed that patients with well controlled disease and good oral hygiene had lower values of the examined periodontal parameters (SBI and PPD) then patients with poorly controlled DM and worse oral hygiene (p lt 0.01 for SBI, p lt 0.05 for PPD). Conclusion. The results of this study indicate the important role of oral hygiene for periodontal status of patients with DM.
AB  - Uvod. Parodontopatija je jedno od najčešćih oboljenja oralne regije kod osoba obolelih od dijabetes melitusa (DM). Cilj ovog istraživanja je bio da se ispita uticaj nivoa glikoziliranog hemoglobina (HbA1c) i stepena oralne higijene na stanje parodoncijuma bolesnika sa DM. Materijal i metode rada. Ispitano je 50 osoba sa DM tip 2 koje su odabrane metodom slučajnog uzorka. Na osnovu vrednosti HbA1c, ispitanici su svrstani u dve grupe: prvu grupu su činili bolesnici koji su dobro kontrolisali DM (HbA1c≤8,5%), a drugu bolesnici s loše kontrolisanim DM (HbA1c>8,5%). Ispitanici dve grupe su dalje podeljeni u podgrupe u zavisnosti od stepena oralne higijene. Svakom bolesniku su prilikom kliničkog pregleda određene vrednosti parodontalnih parametara: plak-indeksa (PI), indeksa krvarenja gingive (IKG), nivoa pripojnog epitela (NPE) i dubine parodontalnog džepa (DPDŽ). Rezultati. Dobijeni rezultati su pokazali da su kod bolesnika sa dobro kontrolisanim oboljenjem i dobrom oralnom higijenom vrednosti ispitivanih parodontalnih parametara (IKG i NPE) niže nego kod bolesnika s loše kontrolisanim DM i lošijom oralnom higijenom (p lt 0,01 za IKG; p lt 0,05 za NPE). Zaključak. Rezultati ovog istraživanja ukazuju na značajnu ulogu oralne higijene na stanje parodoncijuma osoba sa DM.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Periodontal status in patients suffering from diabetes mellitus in relations to glycosylated hemoglobin level and the level of oral hygiene
T1  - Stanje parodoncijuma osoba obolelih od dijabetes melitusa u odnosu na nivo glikoziliranog hemoglobina i oralnu higijenu
VL  - 57
IS  - 3
SP  - 129
EP  - 133
DO  - 10.2298/SGS1003129C
ER  - 

@article{
author = "Cicmil, Smiljka and Stojanović, Nikola and Krunić, Jelena and Vukotić, Olivera and Čakić, Saša",
year = "2010",
abstract = "Introduction. It has been known that periodontitis is one of the most common oral diseases in patients having diabetes mellitus (DM). The aim of this study was to examine the influence of glycosylated hemoglobin (HbA1c) level and the level of oral hygiene on periodontal status of patients suffering from DM. Material and Methods. The research included 50 people with type 2 DM randomly selected. Based on values of HbA1c, patients were divided into two groups: well controlled DM (HbA1c≤8.5%) and poorly controlled DM (HbA1c>8.5%). Patients with poorly and well controlled DM were further grouped into subgroups depending on the level of oral hygiene. For each patient, during the clinical examination, periodontal parameters were determined: plaque index (PI), sulcus bleeding index (SBI), the level of junctional epithelium (LJE) and periodontal pocket depth (PPD). Results. The results showed that patients with well controlled disease and good oral hygiene had lower values of the examined periodontal parameters (SBI and PPD) then patients with poorly controlled DM and worse oral hygiene (p lt 0.01 for SBI, p lt 0.05 for PPD). Conclusion. The results of this study indicate the important role of oral hygiene for periodontal status of patients with DM., Uvod. Parodontopatija je jedno od najčešćih oboljenja oralne regije kod osoba obolelih od dijabetes melitusa (DM). Cilj ovog istraživanja je bio da se ispita uticaj nivoa glikoziliranog hemoglobina (HbA1c) i stepena oralne higijene na stanje parodoncijuma bolesnika sa DM. Materijal i metode rada. Ispitano je 50 osoba sa DM tip 2 koje su odabrane metodom slučajnog uzorka. Na osnovu vrednosti HbA1c, ispitanici su svrstani u dve grupe: prvu grupu su činili bolesnici koji su dobro kontrolisali DM (HbA1c≤8,5%), a drugu bolesnici s loše kontrolisanim DM (HbA1c>8,5%). Ispitanici dve grupe su dalje podeljeni u podgrupe u zavisnosti od stepena oralne higijene. Svakom bolesniku su prilikom kliničkog pregleda određene vrednosti parodontalnih parametara: plak-indeksa (PI), indeksa krvarenja gingive (IKG), nivoa pripojnog epitela (NPE) i dubine parodontalnog džepa (DPDŽ). Rezultati. Dobijeni rezultati su pokazali da su kod bolesnika sa dobro kontrolisanim oboljenjem i dobrom oralnom higijenom vrednosti ispitivanih parodontalnih parametara (IKG i NPE) niže nego kod bolesnika s loše kontrolisanim DM i lošijom oralnom higijenom (p lt 0,01 za IKG; p lt 0,05 za NPE). Zaključak. Rezultati ovog istraživanja ukazuju na značajnu ulogu oralne higijene na stanje parodoncijuma osoba sa DM.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Periodontal status in patients suffering from diabetes mellitus in relations to glycosylated hemoglobin level and the level of oral hygiene, Stanje parodoncijuma osoba obolelih od dijabetes melitusa u odnosu na nivo glikoziliranog hemoglobina i oralnu higijenu",
volume = "57",
number = "3",
pages = "129-133",
doi = "10.2298/SGS1003129C"
}

Cicmil, S., Stojanović, N., Krunić, J., Vukotić, O.,& Čakić, S.. (2010). Periodontal status in patients suffering from diabetes mellitus in relations to glycosylated hemoglobin level and the level of oral hygiene. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 57(3), 129-133.
https://doi.org/10.2298/SGS1003129C

Cicmil S, Stojanović N, Krunić J, Vukotić O, Čakić S. Periodontal status in patients suffering from diabetes mellitus in relations to glycosylated hemoglobin level and the level of oral hygiene. in Stomatološki glasnik Srbije. 2010;57(3):129-133.
doi:10.2298/SGS1003129C .

Cicmil, Smiljka, Stojanović, Nikola, Krunić, Jelena, Vukotić, Olivera, Čakić, Saša, "Periodontal status in patients suffering from diabetes mellitus in relations to glycosylated hemoglobin level and the level of oral hygiene" in Stomatološki glasnik Srbije, 57, no. 3 (2010):129-133,
https://doi.org/10.2298/SGS1003129C . .

TY  - JOUR
AU  - Hadži-Mihailović, Miloš
AU  - Raybaud, Helene
AU  - Montei, R.
AU  - Čakić, Saša
AU  - Đurić, M.
AU  - Janković, Ljiljana
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1591
AB  - Purpose: The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of the expression of the Bcl-2 marker in healthy individuals (H), patients with OLP and patients with squamous cell carcinoma (SCC), and to establish potential interdependence between expression of Bcl-2 and the different clinical and histopathological parameters in H, OLP, and SCC. Methods: Immunohistochemistry for Bcl-2 was carried out using an avidin-biotin peroxidase complex method. Tissue sections were treated with mouse monoclonal antibody against Bcl-2 (124, DAKO A/S, Denmark; dilution 1/100). Immunohistochemical parameters measured included total tissue area, total stained area and intensity of stain. Results: Keratinocytes were not Bcl-2 positive in H and were sparsely positive in OLP. The number of lymphocytes stained with Bcl-2 was significantly lower in Has compared to patients with SCC and OLP. Bcl-2 staining was weak to moderate in OLP, and moderate to intense in SCC. Bcl-2-positive lymphocytes were more expressed in older OLP patients (>55 years), and in OLP specimens with orthokeratinized epithelium, less developed acanthosis and highest grade of lymphocyte expression. Conclusion: Bcl-2 may not serve as a prognostic biomarker in oral cancer development from OLP, but it could help in selecting patients with higher need of follow up to prevent malignancy.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus
VL  - 15
IS  - 2
SP  - 362
EP  - 368
UR  - https://hdl.handle.net/21.15107/rcub_smile_1591
ER  - 

@article{
author = "Hadži-Mihailović, Miloš and Raybaud, Helene and Montei, R. and Čakić, Saša and Đurić, M. and Janković, Ljiljana",
year = "2010",
abstract = "Purpose: The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of the expression of the Bcl-2 marker in healthy individuals (H), patients with OLP and patients with squamous cell carcinoma (SCC), and to establish potential interdependence between expression of Bcl-2 and the different clinical and histopathological parameters in H, OLP, and SCC. Methods: Immunohistochemistry for Bcl-2 was carried out using an avidin-biotin peroxidase complex method. Tissue sections were treated with mouse monoclonal antibody against Bcl-2 (124, DAKO A/S, Denmark; dilution 1/100). Immunohistochemical parameters measured included total tissue area, total stained area and intensity of stain. Results: Keratinocytes were not Bcl-2 positive in H and were sparsely positive in OLP. The number of lymphocytes stained with Bcl-2 was significantly lower in Has compared to patients with SCC and OLP. Bcl-2 staining was weak to moderate in OLP, and moderate to intense in SCC. Bcl-2-positive lymphocytes were more expressed in older OLP patients (>55 years), and in OLP specimens with orthokeratinized epithelium, less developed acanthosis and highest grade of lymphocyte expression. Conclusion: Bcl-2 may not serve as a prognostic biomarker in oral cancer development from OLP, but it could help in selecting patients with higher need of follow up to prevent malignancy.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus",
volume = "15",
number = "2",
pages = "362-368",
url = "https://hdl.handle.net/21.15107/rcub_smile_1591"
}

Hadži-Mihailović, M., Raybaud, H., Montei, R., Čakić, S., Đurić, M.,& Janković, L.. (2010). Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 15(2), 362-368.
https://hdl.handle.net/21.15107/rcub_smile_1591

Hadži-Mihailović M, Raybaud H, Montei R, Čakić S, Đurić M, Janković L. Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus. in Journal of BUON. 2010;15(2):362-368.
https://hdl.handle.net/21.15107/rcub_smile_1591 .

Hadži-Mihailović, Miloš, Raybaud, Helene, Montei, R., Čakić, Saša, Đurić, M., Janković, Ljiljana, "Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus" in Journal of BUON, 15, no. 2 (2010):362-368,
https://hdl.handle.net/21.15107/rcub_smile_1591 .

TY  - JOUR
AU  - Đurić, M.
AU  - Čakić, Saša
AU  - Hadži-Mihailović, Miloš
AU  - Petrović, D.
AU  - Janković, Ljiljana
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1562
AB  - Purpose: Oral complications are frequent and troublesome symptoms for those undergoing chemotherapy for cancer Several antineoplastic agents are proved to have stomatotoxic potential, among them 5-fluorouracil (5-FU). The aim of the present study was to evaluate the oral status and patient experiences during chemotherapy with 5-FU for colorectal cancer Methods: Twenty-eight patients treated with 5-day 5-FU plus leucovorin entered this study. Positive data about oral symptoms were taken by anamnesis. Mucositis severity index, gingival index, plaque index, probing pocket depth and bleeding on probing have been used to assess oral mucosa and periodontal status of the patients. Patients were examined prior to chemotherapy and 14 days after the start of the chemotherapy cycle. Results: Mild to moderate subjective complaints concerning oral cavity were reported by 17.9% of patients before and 39.2% of patients after chemotherapy. Clinical examination revealed oral mucosa damage in 10.7% and 35.7% of patients, with mean mucositis score of 0.14 and 0.54 before and after chemotherapy, respectively. Although mean values of all periodontal indices were elevated after chemotherapy, only increase in gingival index was statistically significant (p=0.035). Mucositis was significantly correlated with oral pain (p=0.00), xerostomia (p=0.00), and plaque index (p=0.077), while the correlation between mucositis and the rest of the examined parameters was not significant. Conclusion: Oral complications were not highly expressed in this study Although 5-FU is considered to exert significant stomatotoxic effect, severe mucositis was far less common in this study compared to studies reported elsewhere.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Oral status in patients receiving 5-fluorouracil for colorectal cancer
VL  - 15
IS  - 3
SP  - 475
EP  - 479
UR  - https://hdl.handle.net/21.15107/rcub_smile_1562
ER  - 

@article{
author = "Đurić, M. and Čakić, Saša and Hadži-Mihailović, Miloš and Petrović, D. and Janković, Ljiljana",
year = "2010",
abstract = "Purpose: Oral complications are frequent and troublesome symptoms for those undergoing chemotherapy for cancer Several antineoplastic agents are proved to have stomatotoxic potential, among them 5-fluorouracil (5-FU). The aim of the present study was to evaluate the oral status and patient experiences during chemotherapy with 5-FU for colorectal cancer Methods: Twenty-eight patients treated with 5-day 5-FU plus leucovorin entered this study. Positive data about oral symptoms were taken by anamnesis. Mucositis severity index, gingival index, plaque index, probing pocket depth and bleeding on probing have been used to assess oral mucosa and periodontal status of the patients. Patients were examined prior to chemotherapy and 14 days after the start of the chemotherapy cycle. Results: Mild to moderate subjective complaints concerning oral cavity were reported by 17.9% of patients before and 39.2% of patients after chemotherapy. Clinical examination revealed oral mucosa damage in 10.7% and 35.7% of patients, with mean mucositis score of 0.14 and 0.54 before and after chemotherapy, respectively. Although mean values of all periodontal indices were elevated after chemotherapy, only increase in gingival index was statistically significant (p=0.035). Mucositis was significantly correlated with oral pain (p=0.00), xerostomia (p=0.00), and plaque index (p=0.077), while the correlation between mucositis and the rest of the examined parameters was not significant. Conclusion: Oral complications were not highly expressed in this study Although 5-FU is considered to exert significant stomatotoxic effect, severe mucositis was far less common in this study compared to studies reported elsewhere.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Oral status in patients receiving 5-fluorouracil for colorectal cancer",
volume = "15",
number = "3",
pages = "475-479",
url = "https://hdl.handle.net/21.15107/rcub_smile_1562"
}

Đurić, M., Čakić, S., Hadži-Mihailović, M., Petrović, D.,& Janković, L.. (2010). Oral status in patients receiving 5-fluorouracil for colorectal cancer. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 15(3), 475-479.
https://hdl.handle.net/21.15107/rcub_smile_1562

Đurić M, Čakić S, Hadži-Mihailović M, Petrović D, Janković L. Oral status in patients receiving 5-fluorouracil for colorectal cancer. in Journal of BUON. 2010;15(3):475-479.
https://hdl.handle.net/21.15107/rcub_smile_1562 .

Đurić, M., Čakić, Saša, Hadži-Mihailović, Miloš, Petrović, D., Janković, Ljiljana, "Oral status in patients receiving 5-fluorouracil for colorectal cancer" in Journal of BUON, 15, no. 3 (2010):475-479,
https://hdl.handle.net/21.15107/rcub_smile_1562 .

TY  - JOUR
AU  - Petrović, Vanja
AU  - Danilović, Vesna
AU  - Marković, Dejan
AU  - Čakić, Saša
AU  - Krstić, N.
AU  - Marković, Danica
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1479
AB  - There are very few data about the effects of endogenous growth factors in vital pulp therapy, and still they are often controversial. This study was undertaken with the aim to evaluate the effects of platelet rich plasma (PRP) in conjugation with hydroxyapatite (HAP), as pulp capping materials, on root and periodontium formation. Eight young monkeys (Cercopithecus Aethiops) with permanent dentition and incomplete root formation were involved in this study. After pulpotomy, the pulp lesion was capped with calcium hydroxide (control), HAP (experimental) or HAP in conjugation with PRP (experimental). Six moths later, the animals were sacrificed, the tissue was removed en block, and prepared for histological analysis in a routine way. The results of histological analysis revealed that the healing process, characterized by dentin bridge formation, maintained morphological and functional integrity of dental pulp and complete formation of dental root and surrounding periodontium. The inflammatory reaction was scored as mild to moderate, in almost all samples in all groups, suggesting the biocompatibility of the used materials. Materials used in this study are convenient as capping agents, contributing in maintaining the integrity of the pulp tissue and facilitating root and periodontium formation. According to histological data it could be suggested that hydroxyapatite in conjugation with endogenous growth factors, represent a superior alternative to other materials used in this study.
AB  - Podaci iz literature o primeni faktora rasta u vitalnoj terapiji pulpe su oskudni i često kontraverzni. Cilj našeg rada je bio da se ispita uticaj plazme bogate trombocitima u kombinaciji sa hidroksiapatitom, kao materijala za direktno prekrivanje pulpe, na završetak rasta korena i formiranje okolnog parodoncijuma. Istraživanje je sprovedeno na osam mladih majmuna (Cercopithecus aethiops), sa stalnom denticijom i nezavršenim rastom korena. Nakon pulpotomije, pulpna lezija je prekrivena kalcijum hidroksidom (kontolna grupa), hidroksiapatitom (eksperimentalna grupa I) ili hidroksiapatitom u kombinaciji sa plazmom bogatom trombocitima (eksperimentalna grupa II). Šest meseci kasnije životinje su žrtvovane, a uzeto tkivo pripremljeno je za histološku analizu. Rezultati histološke analize ukazali su da je zarastanje bilo karakterisano stvaranjem mineralizovanog dentinskog mostića, uz očuvanje morfološkog i funkcionalnog integriteta pulpe i završetak rasta korena i okolnog parodoncijuma u uzorcima svih ispitivanih grupa. Zapaljenska reakcija je gotovo u svim ispitivnim uzorcima bila ocenjena kao blaga ili umerena, što govori u prilog biokompatibilnosti primenjenih materijala. Na osnovu dobijenih rezultata može se reći da su svi primenjeni materijali pogodni za direktno prekrivanje pulpe, da doprinose očuvanju integriteta pulpe i ubrzavaju završetak rasta korena i formiranje apikalnog parodoncijuma, s tim što hidroksipatit u kombinaciji sa endogenim faktorima rasta predstavlja superiorniju alternativu u odnosu na druge materijale korišćene u ovoj studiji.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - The effects of hydroxyapatite and platelet rich plasma on apexogenesis in monkeys
T1  - Uticaj hidroksiapatita i plazme bogate trombocitima na proces apeksogeneze kod majmuna
VL  - 59
IS  - 2-3
SP  - 277
EP  - 289
DO  - 10.2298/AVB0903277P
ER  - 

@article{
author = "Petrović, Vanja and Danilović, Vesna and Marković, Dejan and Čakić, Saša and Krstić, N. and Marković, Danica",
year = "2009",
abstract = "There are very few data about the effects of endogenous growth factors in vital pulp therapy, and still they are often controversial. This study was undertaken with the aim to evaluate the effects of platelet rich plasma (PRP) in conjugation with hydroxyapatite (HAP), as pulp capping materials, on root and periodontium formation. Eight young monkeys (Cercopithecus Aethiops) with permanent dentition and incomplete root formation were involved in this study. After pulpotomy, the pulp lesion was capped with calcium hydroxide (control), HAP (experimental) or HAP in conjugation with PRP (experimental). Six moths later, the animals were sacrificed, the tissue was removed en block, and prepared for histological analysis in a routine way. The results of histological analysis revealed that the healing process, characterized by dentin bridge formation, maintained morphological and functional integrity of dental pulp and complete formation of dental root and surrounding periodontium. The inflammatory reaction was scored as mild to moderate, in almost all samples in all groups, suggesting the biocompatibility of the used materials. Materials used in this study are convenient as capping agents, contributing in maintaining the integrity of the pulp tissue and facilitating root and periodontium formation. According to histological data it could be suggested that hydroxyapatite in conjugation with endogenous growth factors, represent a superior alternative to other materials used in this study., Podaci iz literature o primeni faktora rasta u vitalnoj terapiji pulpe su oskudni i često kontraverzni. Cilj našeg rada je bio da se ispita uticaj plazme bogate trombocitima u kombinaciji sa hidroksiapatitom, kao materijala za direktno prekrivanje pulpe, na završetak rasta korena i formiranje okolnog parodoncijuma. Istraživanje je sprovedeno na osam mladih majmuna (Cercopithecus aethiops), sa stalnom denticijom i nezavršenim rastom korena. Nakon pulpotomije, pulpna lezija je prekrivena kalcijum hidroksidom (kontolna grupa), hidroksiapatitom (eksperimentalna grupa I) ili hidroksiapatitom u kombinaciji sa plazmom bogatom trombocitima (eksperimentalna grupa II). Šest meseci kasnije životinje su žrtvovane, a uzeto tkivo pripremljeno je za histološku analizu. Rezultati histološke analize ukazali su da je zarastanje bilo karakterisano stvaranjem mineralizovanog dentinskog mostića, uz očuvanje morfološkog i funkcionalnog integriteta pulpe i završetak rasta korena i okolnog parodoncijuma u uzorcima svih ispitivanih grupa. Zapaljenska reakcija je gotovo u svim ispitivnim uzorcima bila ocenjena kao blaga ili umerena, što govori u prilog biokompatibilnosti primenjenih materijala. Na osnovu dobijenih rezultata može se reći da su svi primenjeni materijali pogodni za direktno prekrivanje pulpe, da doprinose očuvanju integriteta pulpe i ubrzavaju završetak rasta korena i formiranje apikalnog parodoncijuma, s tim što hidroksipatit u kombinaciji sa endogenim faktorima rasta predstavlja superiorniju alternativu u odnosu na druge materijale korišćene u ovoj studiji.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "The effects of hydroxyapatite and platelet rich plasma on apexogenesis in monkeys, Uticaj hidroksiapatita i plazme bogate trombocitima na proces apeksogeneze kod majmuna",
volume = "59",
number = "2-3",
pages = "277-289",
doi = "10.2298/AVB0903277P"
}

Petrović, V., Danilović, V., Marković, D., Čakić, S., Krstić, N.,& Marković, D.. (2009). The effects of hydroxyapatite and platelet rich plasma on apexogenesis in monkeys. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 59(2-3), 277-289.
https://doi.org/10.2298/AVB0903277P

Petrović V, Danilović V, Marković D, Čakić S, Krstić N, Marković D. The effects of hydroxyapatite and platelet rich plasma on apexogenesis in monkeys. in Acta veterinaria. 2009;59(2-3):277-289.
doi:10.2298/AVB0903277P .

Petrović, Vanja, Danilović, Vesna, Marković, Dejan, Čakić, Saša, Krstić, N., Marković, Danica, "The effects of hydroxyapatite and platelet rich plasma on apexogenesis in monkeys" in Acta veterinaria, 59, no. 2-3 (2009):277-289,
https://doi.org/10.2298/AVB0903277P . .

TY  - JOUR
AU  - Luković, Natalija
AU  - Zelić, Obrad
AU  - Čakić, Saša
AU  - Petrović, Vanja
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1461
AB  - Introduction. The primary goal of bone regeneration procedures with application of various regenerative biologic agents and biomaterials is to facilitate the formation of periodontal tissues lost as a result of periodontitis. Objective. The aim of the study was to compare clinical outcome of the guided tissue regeneration (GTR) treatment with the use of β-tricalcium phosphate and with bovine bone matrix in human deep intra-osseous defects. Methods. Twenty-one systemically healthy subjects with moderate to advanced periodontitis, between 30 and 56 years of age, 11 females and 10 males, were selected. Patients having two similar inter-proximal defects with pocket probing depths following initial therapy greater than 5 mm were recruited for the study. Experimental sites were grafted with pure β-tricalcium phosphate biomaterial (Cerasorb®) and a biomembrane, while control sites were treated with bovine-bone hydroxiapatite xenograft (Bio-oss®) and a biomembrane. Immediately before surgery and 12 months after surgery, pocket probing depth (PPD), epithelial attachment level (EAL) and gingival recession (GR) were evaluated. Results. In the experimental group PPD amounted to 6.76±0.83 mm before surgery, and decreased significantly to 2.67±0.48 mm 12 months following surgery, while in the control group PPD significantly decreased from 7.14±0.65 mm presurgically to 2.85±0.57 mm postsurgically. After one year, EAL gain was 2.76±0.99 mm in the experimental group, and 3.24±0.16 mm in the control group. After twelve months postoperatively GR amounted to 1.33±0.79 mm in the experimental group and to 1.05±0.80 mm in the control group. No statistically significant differences for PPD reduction, EAL gain and GR increase were detected between the groups. Conclusion. Results from the present study indicate that GTR treatment of deep intra-osseous defects with Bio-oss® and Cerasorb® resulted in clinically and statistically significant improvement of EAL gain and PPD reduction. A GR was slightly increased, with no statistical significance.
AB  - Uvod. Za regeneraciju tkiva koje je izgubljeno tokom parodontopatije koriste se razni biološki i sintetski materijali s različitim uspehom. Oni se najčešće primenjuju za obnavljanje pripojnog epitela i gubljenje alveolarne kosti u dubokim infrakoštanim oštećenjima. Cilj rada. Cilj rada je bio da se ispita značaj primene beta trikalcijum-fosfata i hidroksiapatita u lečenju dubokih infrakoštanih oštećenja. Metode rada. U istraživanje je uključena dvadeset i jedna zdrava osoba (11 žena i 10 muškaraca) starosti 30-45 godina kod koje je dijagnostikovana parodontopatija. Kod svih ispitanika ustanovljena su dva slična oštećenja sa dubinom sondiranja džepa od preko 5 mm. Tzv. eksperimentalna strana je tretirana čistim beta trikalcijum-fosfatnim biomaterijalom (Cerasorb®) i biomembranom, dok je tzv. kontrolna strana tretirana hidroksiapatitnim goveđim koštanim ksenograftom (Bio-oss®) i biomembranom. Dubina sondiranja džepa, nivo pripojenog epitela i recesija gingive su zabeleženi neposredno pre intervencije i 12 meseci kasnije. Rezultati. U eksperimentalnoj grupi dubina sondiranja džepa je bila 6,76±0,83 mm pre intervencije, a značajno manja nakon 12 meseci (2,76±0,48 mm). U kontrolnoj grupi ona je bila 7,14±0,65 mm pre intervencije, a značajno manja na kontrolnom pregledu (2,85±0,57 mm). Posle godinu dana nivo pripojenog epitela se povećao 2,76±0,99 mm u eksperimentalnoj grupi, odnosno 3,24±0,16 mm u kontrolnoj. Dvanaest meseci nakon intervencije recesija gingive bila je 1,33±0,79 mm u eksperimentalnoj, odnosno 1,05±0,80 mm u kontrolnoj grupi. Nisu zabeležene statistički značajne razlike u vrednosti dubine sondiranja džepa, nivou pripojenog epitela i recesiji gingive između kontrolne i eksperimentalne grupe. Zaključak. Tretman dubokih infrakoštanih oštećenja beta trikalcijum-fosfatom i hidroksiapatitom dao je dobre kliničke rezultate, budući da se značajno smanjila dubina oštećenja, a nivo pripojenog epitela podigao. Recesija gingive se umanjila, ali bez statistički značajne razlike.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects
T1  - Primena beta trikalcijum-fosfata i goveđeg koštanog matriksa u vođenoj regeneraciji dubokih infrakoštanih parodontalnih oštećenja
VL  - 137
IS  - 11-12
SP  - 607
EP  - 612
DO  - 10.2298/SARH0912607L
ER  - 

@article{
author = "Luković, Natalija and Zelić, Obrad and Čakić, Saša and Petrović, Vanja",
year = "2009",
abstract = "Introduction. The primary goal of bone regeneration procedures with application of various regenerative biologic agents and biomaterials is to facilitate the formation of periodontal tissues lost as a result of periodontitis. Objective. The aim of the study was to compare clinical outcome of the guided tissue regeneration (GTR) treatment with the use of β-tricalcium phosphate and with bovine bone matrix in human deep intra-osseous defects. Methods. Twenty-one systemically healthy subjects with moderate to advanced periodontitis, between 30 and 56 years of age, 11 females and 10 males, were selected. Patients having two similar inter-proximal defects with pocket probing depths following initial therapy greater than 5 mm were recruited for the study. Experimental sites were grafted with pure β-tricalcium phosphate biomaterial (Cerasorb®) and a biomembrane, while control sites were treated with bovine-bone hydroxiapatite xenograft (Bio-oss®) and a biomembrane. Immediately before surgery and 12 months after surgery, pocket probing depth (PPD), epithelial attachment level (EAL) and gingival recession (GR) were evaluated. Results. In the experimental group PPD amounted to 6.76±0.83 mm before surgery, and decreased significantly to 2.67±0.48 mm 12 months following surgery, while in the control group PPD significantly decreased from 7.14±0.65 mm presurgically to 2.85±0.57 mm postsurgically. After one year, EAL gain was 2.76±0.99 mm in the experimental group, and 3.24±0.16 mm in the control group. After twelve months postoperatively GR amounted to 1.33±0.79 mm in the experimental group and to 1.05±0.80 mm in the control group. No statistically significant differences for PPD reduction, EAL gain and GR increase were detected between the groups. Conclusion. Results from the present study indicate that GTR treatment of deep intra-osseous defects with Bio-oss® and Cerasorb® resulted in clinically and statistically significant improvement of EAL gain and PPD reduction. A GR was slightly increased, with no statistical significance., Uvod. Za regeneraciju tkiva koje je izgubljeno tokom parodontopatije koriste se razni biološki i sintetski materijali s različitim uspehom. Oni se najčešće primenjuju za obnavljanje pripojnog epitela i gubljenje alveolarne kosti u dubokim infrakoštanim oštećenjima. Cilj rada. Cilj rada je bio da se ispita značaj primene beta trikalcijum-fosfata i hidroksiapatita u lečenju dubokih infrakoštanih oštećenja. Metode rada. U istraživanje je uključena dvadeset i jedna zdrava osoba (11 žena i 10 muškaraca) starosti 30-45 godina kod koje je dijagnostikovana parodontopatija. Kod svih ispitanika ustanovljena su dva slična oštećenja sa dubinom sondiranja džepa od preko 5 mm. Tzv. eksperimentalna strana je tretirana čistim beta trikalcijum-fosfatnim biomaterijalom (Cerasorb®) i biomembranom, dok je tzv. kontrolna strana tretirana hidroksiapatitnim goveđim koštanim ksenograftom (Bio-oss®) i biomembranom. Dubina sondiranja džepa, nivo pripojenog epitela i recesija gingive su zabeleženi neposredno pre intervencije i 12 meseci kasnije. Rezultati. U eksperimentalnoj grupi dubina sondiranja džepa je bila 6,76±0,83 mm pre intervencije, a značajno manja nakon 12 meseci (2,76±0,48 mm). U kontrolnoj grupi ona je bila 7,14±0,65 mm pre intervencije, a značajno manja na kontrolnom pregledu (2,85±0,57 mm). Posle godinu dana nivo pripojenog epitela se povećao 2,76±0,99 mm u eksperimentalnoj grupi, odnosno 3,24±0,16 mm u kontrolnoj. Dvanaest meseci nakon intervencije recesija gingive bila je 1,33±0,79 mm u eksperimentalnoj, odnosno 1,05±0,80 mm u kontrolnoj grupi. Nisu zabeležene statistički značajne razlike u vrednosti dubine sondiranja džepa, nivou pripojenog epitela i recesiji gingive između kontrolne i eksperimentalne grupe. Zaključak. Tretman dubokih infrakoštanih oštećenja beta trikalcijum-fosfatom i hidroksiapatitom dao je dobre kliničke rezultate, budući da se značajno smanjila dubina oštećenja, a nivo pripojenog epitela podigao. Recesija gingive se umanjila, ali bez statistički značajne razlike.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects, Primena beta trikalcijum-fosfata i goveđeg koštanog matriksa u vođenoj regeneraciji dubokih infrakoštanih parodontalnih oštećenja",
volume = "137",
number = "11-12",
pages = "607-612",
doi = "10.2298/SARH0912607L"
}

Luković, N., Zelić, O., Čakić, S.,& Petrović, V.. (2009). The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 137(11-12), 607-612.
https://doi.org/10.2298/SARH0912607L

Luković N, Zelić O, Čakić S, Petrović V. The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects. in Srpski arhiv za celokupno lekarstvo. 2009;137(11-12):607-612.
doi:10.2298/SARH0912607L .

Luković, Natalija, Zelić, Obrad, Čakić, Saša, Petrović, Vanja, "The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects" in Srpski arhiv za celokupno lekarstvo, 137, no. 11-12 (2009):607-612,
https://doi.org/10.2298/SARH0912607L . .

TY  - JOUR
AU  - Zarić, S.
AU  - Bojić, B.
AU  - Janković, Ljiljana
AU  - Dapčević, B.
AU  - Popović, Branka
AU  - Čakić, Saša
AU  - Milašin, Jelena
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1501
AB  - The oral cavity has been proposed as a reservoir for H. pylori that could be responsible for the refractoriness of gastric infection to triple therapy (antibiotics, antimicrobials, and proton pump inhibitors). The aim of this study was to evaluate the efficiency of combined periodontal and triple therapy vs. triple therapy alone, in gastric H. pylori eradication in persons with H. pylori in the subgingival biofilm. Individuals positive for H. pylori in their gastric and oral samples, as determined by nested PCR, were treated either with periodontal and triple therapy or with triple therapy alone. Our results indicate that 77.3% of those treated with the combined therapy exhibited successful eradication of gastric H. pylori, compared with 47.6% who underwent only triple therapy. Analysis of these data suggests that periodontal treatment in combination with systemic therapy could be a promising approach to increasing the therapy's efficacy and decreasing the risk of infection recurrence.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Journal of Dental Research
T1  - Periodontal Therapy Improves Gastric Helicobacter pylori Eradication
VL  - 88
IS  - 10
SP  - 946
EP  - 950
DO  - 10.1177/0022034509344559
ER  - 

@article{
author = "Zarić, S. and Bojić, B. and Janković, Ljiljana and Dapčević, B. and Popović, Branka and Čakić, Saša and Milašin, Jelena",
year = "2009",
abstract = "The oral cavity has been proposed as a reservoir for H. pylori that could be responsible for the refractoriness of gastric infection to triple therapy (antibiotics, antimicrobials, and proton pump inhibitors). The aim of this study was to evaluate the efficiency of combined periodontal and triple therapy vs. triple therapy alone, in gastric H. pylori eradication in persons with H. pylori in the subgingival biofilm. Individuals positive for H. pylori in their gastric and oral samples, as determined by nested PCR, were treated either with periodontal and triple therapy or with triple therapy alone. Our results indicate that 77.3% of those treated with the combined therapy exhibited successful eradication of gastric H. pylori, compared with 47.6% who underwent only triple therapy. Analysis of these data suggests that periodontal treatment in combination with systemic therapy could be a promising approach to increasing the therapy's efficacy and decreasing the risk of infection recurrence.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Journal of Dental Research",
title = "Periodontal Therapy Improves Gastric Helicobacter pylori Eradication",
volume = "88",
number = "10",
pages = "946-950",
doi = "10.1177/0022034509344559"
}

Zarić, S., Bojić, B., Janković, L., Dapčević, B., Popović, B., Čakić, S.,& Milašin, J.. (2009). Periodontal Therapy Improves Gastric Helicobacter pylori Eradication. in Journal of Dental Research
Sage Publications Inc, Thousand Oaks., 88(10), 946-950.
https://doi.org/10.1177/0022034509344559

Zarić S, Bojić B, Janković L, Dapčević B, Popović B, Čakić S, Milašin J. Periodontal Therapy Improves Gastric Helicobacter pylori Eradication. in Journal of Dental Research. 2009;88(10):946-950.
doi:10.1177/0022034509344559 .

Zarić, S., Bojić, B., Janković, Ljiljana, Dapčević, B., Popović, Branka, Čakić, Saša, Milašin, Jelena, "Periodontal Therapy Improves Gastric Helicobacter pylori Eradication" in Journal of Dental Research, 88, no. 10 (2009):946-950,
https://doi.org/10.1177/0022034509344559 . .

TY  - JOUR
AU  - Zelić, Obrad
AU  - Čakić, Saša
AU  - Luković, Natalija
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1506
AB  - Introduction. Since the discovery that periodontal diseases are caused by microbial plaque the interest of many scientists has been focused on oral antiseptics. There are very few mouthrinses with oral antiseptic effect originally designed in our country. One of these is Ozosept® solution. Objective. This study evaluated the effect of Ozosept® solution (phenol compound) on the oral hygiene and gingival inflammation, in comparison with Hibidex DAP® solution (chlorhexidine digluconate). Methods. Two groups, each of 21 persons, which did not significantly differ concerning Silness-Löe plaque index (PI) and Löe-Sillnes gingival index (GI), used one of the studied oral antiseptic for a 15-day period. Oral hygiene was maintained by subjects' habitual home methods, and no technique of professionally advised brushing was performed during the experimental period. Results. At the end of the study, PI and GI scores were lowered to a statistically high significance in both groups of participants in comparison to the indexes at the beginning of the study. At the end of the study, PI and GI scores did not significantly differ between the two analyzed groups. No side effects, which were recorded in the Hibidex DAP® group (tooth and filling staining 9.5% and 4.74% respectively, transitory tongue numbness 28.6% and reduced taste sensation 14.3%), were registered in the group of subjects using Ozosept® solution. Conclusion. It is concluded that Ozosept® solution is effective in the control of dental plaque - biofilm accumulation and gingival inflammation, and produces no side effects related to chlorhexidine digluconate usage.
AB  - Uvod. Oralni antiseptici su predmet mnogih istraživanja veoma dugo - od trenutka kada je otkriveno da su oboljenja potpornog aparata zuba bakterijskog porekla. Malo je, međutim, originalnih domaćih preparata s antiseptičkim dejstvom za ispiranje usne duplje. Cilj rada. Cilj rada je bio da se ispita efekat rastvora Ozosept® (fenolna jedinjenja) na oralnu higijenu i zapaljenje gingive, te uporedi s učinkom rastvora Hibidex DAP® (hlorheksidin-diglukonat). Metode rada. U istraživanje su uključene dve grupe od po 21 ispitanika koje su u pogledu Silnes-Loevog (Silness-Löe) plak-indeksa (PI) i Loe-Silnesovog (Löe-Silness) gingivnog indeksa (GI) predstavljale statistički homogenu grupu, odnosno koje su na početku eksperimentalnog perioda koristile jedan od navedenih oralnih antiseptika tokom 15 dana. Tokom eksperimentalnog perioda ispitanici su održavali oralnu higijenu na dotada uobičajeni način i nije primenjivana nijedna metoda profesionalnog čišćenja zuba. Rezultati. U obe grupe ispitanika vrednosti PI i GI su na kraju eksperimenta bile smanjene sa statistički visokom značajnošću u odnosu na vrednosti na početku ispitivanja. Vrednosti PI i GI na kraju eksperimenta se nisu značajno razlikovale između posmatranih grupa. Takođe, kod ispitanika koji su primenjivali rastvor Ozosept® nije uočen nijedan neželjeni efekat, dok je u grupi koja je primenjivala rastvor Hibidex DAP® prebojenost zuba uočena kod 9,5% ispitanika, prebojenost plombi kod 4,75%, prolazna utrnulost jezika kod 28,6%, a smanjenje percepcije ukusa kod 14,3% ispitanika. Zaključak. Rastvor Ozosept® je efikasno sredstvo u kontroli akumulacije dentalnog plaka (biofilma) i zapaljenja gingive i ne stvara neželjene efekte.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation
T1  - Uticaj dva različita oralna antiseptika na akumulaciju dentalnog plaka (biofilma) i zapaljenje gingive
VL  - 137
IS  - 1-2
SP  - 6
EP  - 9
DO  - 10.2298/SARH0902006Z
ER  - 

@article{
author = "Zelić, Obrad and Čakić, Saša and Luković, Natalija",
year = "2009",
abstract = "Introduction. Since the discovery that periodontal diseases are caused by microbial plaque the interest of many scientists has been focused on oral antiseptics. There are very few mouthrinses with oral antiseptic effect originally designed in our country. One of these is Ozosept® solution. Objective. This study evaluated the effect of Ozosept® solution (phenol compound) on the oral hygiene and gingival inflammation, in comparison with Hibidex DAP® solution (chlorhexidine digluconate). Methods. Two groups, each of 21 persons, which did not significantly differ concerning Silness-Löe plaque index (PI) and Löe-Sillnes gingival index (GI), used one of the studied oral antiseptic for a 15-day period. Oral hygiene was maintained by subjects' habitual home methods, and no technique of professionally advised brushing was performed during the experimental period. Results. At the end of the study, PI and GI scores were lowered to a statistically high significance in both groups of participants in comparison to the indexes at the beginning of the study. At the end of the study, PI and GI scores did not significantly differ between the two analyzed groups. No side effects, which were recorded in the Hibidex DAP® group (tooth and filling staining 9.5% and 4.74% respectively, transitory tongue numbness 28.6% and reduced taste sensation 14.3%), were registered in the group of subjects using Ozosept® solution. Conclusion. It is concluded that Ozosept® solution is effective in the control of dental plaque - biofilm accumulation and gingival inflammation, and produces no side effects related to chlorhexidine digluconate usage., Uvod. Oralni antiseptici su predmet mnogih istraživanja veoma dugo - od trenutka kada je otkriveno da su oboljenja potpornog aparata zuba bakterijskog porekla. Malo je, međutim, originalnih domaćih preparata s antiseptičkim dejstvom za ispiranje usne duplje. Cilj rada. Cilj rada je bio da se ispita efekat rastvora Ozosept® (fenolna jedinjenja) na oralnu higijenu i zapaljenje gingive, te uporedi s učinkom rastvora Hibidex DAP® (hlorheksidin-diglukonat). Metode rada. U istraživanje su uključene dve grupe od po 21 ispitanika koje su u pogledu Silnes-Loevog (Silness-Löe) plak-indeksa (PI) i Loe-Silnesovog (Löe-Silness) gingivnog indeksa (GI) predstavljale statistički homogenu grupu, odnosno koje su na početku eksperimentalnog perioda koristile jedan od navedenih oralnih antiseptika tokom 15 dana. Tokom eksperimentalnog perioda ispitanici su održavali oralnu higijenu na dotada uobičajeni način i nije primenjivana nijedna metoda profesionalnog čišćenja zuba. Rezultati. U obe grupe ispitanika vrednosti PI i GI su na kraju eksperimenta bile smanjene sa statistički visokom značajnošću u odnosu na vrednosti na početku ispitivanja. Vrednosti PI i GI na kraju eksperimenta se nisu značajno razlikovale između posmatranih grupa. Takođe, kod ispitanika koji su primenjivali rastvor Ozosept® nije uočen nijedan neželjeni efekat, dok je u grupi koja je primenjivala rastvor Hibidex DAP® prebojenost zuba uočena kod 9,5% ispitanika, prebojenost plombi kod 4,75%, prolazna utrnulost jezika kod 28,6%, a smanjenje percepcije ukusa kod 14,3% ispitanika. Zaključak. Rastvor Ozosept® je efikasno sredstvo u kontroli akumulacije dentalnog plaka (biofilma) i zapaljenja gingive i ne stvara neželjene efekte.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation, Uticaj dva različita oralna antiseptika na akumulaciju dentalnog plaka (biofilma) i zapaljenje gingive",
volume = "137",
number = "1-2",
pages = "6-9",
doi = "10.2298/SARH0902006Z"
}

Zelić, O., Čakić, S.,& Luković, N.. (2009). The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 137(1-2), 6-9.
https://doi.org/10.2298/SARH0902006Z

Zelić O, Čakić S, Luković N. The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation. in Srpski arhiv za celokupno lekarstvo. 2009;137(1-2):6-9.
doi:10.2298/SARH0902006Z .

Zelić, Obrad, Čakić, Saša, Luković, Natalija, "The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation" in Srpski arhiv za celokupno lekarstvo, 137, no. 1-2 (2009):6-9,
https://doi.org/10.2298/SARH0902006Z . .

TY  - JOUR
AU  - Hadži-Mihailović, Miloš
AU  - Janković, Ljiljana
AU  - Čakić, Saša
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1466
AB  - Introduction. Sjögren's syndrome (SS) is a chronic autoimmune disorder, with its major clinical manifestations resulting from changes in exocrine glands. Objective The aim of this study was to evaluate serum concentrations of circulating immune complexes (CIC) and immunoglobulin G (IgG), and salivary proteins (SP) and salivary immunoglobulin A (sIgA) in 40 patients with SS, and to correlate these values among themselves, as well as with the unstimulated salivary flow rate (USFR) and the duration of disease. Methods. The total of 40 patients were included in this research. CIC was determined using the solution of polyethylene glycol and IgG with the standard procedure of radial immunodiffusion. SP was investigated by the method of Lowry and sIgA was separated from the whole saliva using the method of immune chromatography. Results. The values of most of the studied parameters exceeded the normal range in a high degree: CIC 72.5%, IgG 70%, SP 80%. The concentrations of CIC were significantly higher in the patients with the duration of disease less than 10 years. With the decrease of USFR, the concentration of sIgA and IgG were increased with statistical significance. Conclusion The increased prevalence of abnormal values of CIC, IgG and SP indicate that the patients with SS have developed a higher level of immune reactivity. These results could be useful in diagnosis and disease activity monitoring.
AB  - Uvod. Sjegrenov (Sjögren) sindrom (SS) je hronična autoimuna bolest koja nastaje usled patoloških promena u egzokrinim žlezdama. Cilj rada Cilj rada je bio da se koncentracije cirkulatornih imunih kompleksa (CIC) i imunoglobulina G (IgG) u serumu, kao i salivarnih proteina (SP) i salivarnog IgA (sIgA) u pljuvački uporede međusobno i u odnosu na stepen protoka nestimulisane pljuvačke (USFR) i trajanja bolesti. Metode rada. Istraživanje je obuhvatilo 40 bolesnika sa SS. CIC je bio određen korišćenjem rastvora polietilenglikola, a IgG standardnim postupkom radijalne imunodifuzije. SP su izolovani metodom po Loriju (Lowry), dok je sIgA izdvojen iz ukupne pljuvačke korišćenjem metode imune hromatografije. Rezultati. Koncentracije većine ispitanih parametara su u velikoj meri odstupale od njihovih normalnih vrednosti: CIC 72,5%, IgG 70%, SP 80%. Koncentracije CIC su bile statistički značajno veće kod bolesnika čija je bolest trajala manje od 10 godina. Sa smanjenjem USFR koncentracije sIgA i IgG su se povećavale sa statističkom značajnošću. Zaključak. Povećane koncentracije CIC, IgG i SP kod bolesnika sa SS upućuju na povišen nivo imunološke reaktivnosti. Podaci dobijeni u ovom istraživanju mogu biti korisni prilikom posmatranja aktivnosti i dinamike promena kod SS.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Circulating immune complexes, immunoglobulin G, salivary proteins and salivary immunoglobulin A in patients with Sjögren's syndrome
T1  - Cirkulatorni imuni kompleksi, imunoglobulin G, salivarni proteini i salivarni imunoglobulin A kod bolesnika sa Sjegrenovim sindromom
VL  - 137
IS  - 3-4
SP  - 134
EP  - 139
DO  - 10.2298/SARH0904134H
ER  - 

@article{
author = "Hadži-Mihailović, Miloš and Janković, Ljiljana and Čakić, Saša",
year = "2009",
abstract = "Introduction. Sjögren's syndrome (SS) is a chronic autoimmune disorder, with its major clinical manifestations resulting from changes in exocrine glands. Objective The aim of this study was to evaluate serum concentrations of circulating immune complexes (CIC) and immunoglobulin G (IgG), and salivary proteins (SP) and salivary immunoglobulin A (sIgA) in 40 patients with SS, and to correlate these values among themselves, as well as with the unstimulated salivary flow rate (USFR) and the duration of disease. Methods. The total of 40 patients were included in this research. CIC was determined using the solution of polyethylene glycol and IgG with the standard procedure of radial immunodiffusion. SP was investigated by the method of Lowry and sIgA was separated from the whole saliva using the method of immune chromatography. Results. The values of most of the studied parameters exceeded the normal range in a high degree: CIC 72.5%, IgG 70%, SP 80%. The concentrations of CIC were significantly higher in the patients with the duration of disease less than 10 years. With the decrease of USFR, the concentration of sIgA and IgG were increased with statistical significance. Conclusion The increased prevalence of abnormal values of CIC, IgG and SP indicate that the patients with SS have developed a higher level of immune reactivity. These results could be useful in diagnosis and disease activity monitoring., Uvod. Sjegrenov (Sjögren) sindrom (SS) je hronična autoimuna bolest koja nastaje usled patoloških promena u egzokrinim žlezdama. Cilj rada Cilj rada je bio da se koncentracije cirkulatornih imunih kompleksa (CIC) i imunoglobulina G (IgG) u serumu, kao i salivarnih proteina (SP) i salivarnog IgA (sIgA) u pljuvački uporede međusobno i u odnosu na stepen protoka nestimulisane pljuvačke (USFR) i trajanja bolesti. Metode rada. Istraživanje je obuhvatilo 40 bolesnika sa SS. CIC je bio određen korišćenjem rastvora polietilenglikola, a IgG standardnim postupkom radijalne imunodifuzije. SP su izolovani metodom po Loriju (Lowry), dok je sIgA izdvojen iz ukupne pljuvačke korišćenjem metode imune hromatografije. Rezultati. Koncentracije većine ispitanih parametara su u velikoj meri odstupale od njihovih normalnih vrednosti: CIC 72,5%, IgG 70%, SP 80%. Koncentracije CIC su bile statistički značajno veće kod bolesnika čija je bolest trajala manje od 10 godina. Sa smanjenjem USFR koncentracije sIgA i IgG su se povećavale sa statističkom značajnošću. Zaključak. Povećane koncentracije CIC, IgG i SP kod bolesnika sa SS upućuju na povišen nivo imunološke reaktivnosti. Podaci dobijeni u ovom istraživanju mogu biti korisni prilikom posmatranja aktivnosti i dinamike promena kod SS.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Circulating immune complexes, immunoglobulin G, salivary proteins and salivary immunoglobulin A in patients with Sjögren's syndrome, Cirkulatorni imuni kompleksi, imunoglobulin G, salivarni proteini i salivarni imunoglobulin A kod bolesnika sa Sjegrenovim sindromom",
volume = "137",
number = "3-4",
pages = "134-139",
doi = "10.2298/SARH0904134H"
}

Hadži-Mihailović, M., Janković, L.,& Čakić, S.. (2009). Circulating immune complexes, immunoglobulin G, salivary proteins and salivary immunoglobulin A in patients with Sjögren's syndrome. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 137(3-4), 134-139.
https://doi.org/10.2298/SARH0904134H

Hadži-Mihailović M, Janković L, Čakić S. Circulating immune complexes, immunoglobulin G, salivary proteins and salivary immunoglobulin A in patients with Sjögren's syndrome. in Srpski arhiv za celokupno lekarstvo. 2009;137(3-4):134-139.
doi:10.2298/SARH0904134H .

Hadži-Mihailović, Miloš, Janković, Ljiljana, Čakić, Saša, "Circulating immune complexes, immunoglobulin G, salivary proteins and salivary immunoglobulin A in patients with Sjögren's syndrome" in Srpski arhiv za celokupno lekarstvo, 137, no. 3-4 (2009):134-139,
https://doi.org/10.2298/SARH0904134H . .

TY  - JOUR
AU  - Čakić, Saša
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1460
AB  - Gingival crevicular fluid (GCF) can be found in the physiologic space (gingival sulcus), as well as in the pathological space (gingival pocket or periodontal pocket) between the gums and teeth. In the first case it is a transudate, in the second an exudate. The constituents of GCF originate from serum, gingival tissues, and from both bacterial and host response cells present in the aforementioned spaces and the surrounding tissues. The collection and analysis of GCF are the noninvasive methods for the evaluation of host response in periodontal disease. These analyses mainly focus on inflammatory markers, such as prostaglandin E2, neutrophil elastase and β-glucuronidase, and on the marker of cellular necrosis - aspartat aminotransferase. Further, the analysis of inflammatory markers in the GCF may assist in defining how certain systemic diseases (e.g., diabetes mellitus) can modify periodontal disease, and how peridontal disease can influence certain systemic disorders (atherosclerosis, preterm delivery, diabetes mellitus and some chronic respiratory diseases). Major factors which influence the results obtained from the analyses of GCF are not only the methods of these analyses, but the method of GCF collection as well. As saliva collection is less technique-sensitive than GCF collection, some constituents of saliva which originate from the GCF can be analyzed as more amenable to chairside utilization.
AB  - Gingivalna tečnost (GT) je tečnost koja se nalazi u fiziološkom (gingivalni sulkus) ili u patološkom prostoru između desni i zuba (gingivalni xep ili parodontalni xep). Ona može da bude transudat seruma ili inflamatorni eksudat. Elementi GT potiču iz seruma, epitela i vezivnog tkiva gingive, kao i iz inflamatornih ćelija i bakterija koje se nalaze u tom prostoru i okolnim tkivima. Prikupljanje i analiza GT je neinvazivna metoda procene odgovora osobe obolele od parodontopatije. Ove analize se uglavnom odnose na pokazatelje zapaljenja, kao što su prostaglandin E2, elastaza neutrofila i beta-glukuronidaza, ili na pokazatelj nekroze ćelija, aspartat- aminotransferazu. Osim toga, analiza pokazatelja zapaljenja u GT mogla bi da pomogne u razjašnjenju načina na koji neke sistemske bolesti (npr. diabetes mellitus) menjaju kliničku sliku parodontopatije s jedne strane, i kako zapaljenje parodoncijuma, tj. parodontopatija, može da utiče na razvoj nekih sistemskih bolesti (kardiovaskularnih, cerebrovaskularnih) sa druge. Važni činioci koji utiču na rezultate analiza GT su ne samo metode tih analiza, već i metode prikupljanja GT. Praktični razlozi upućuju i na analizu nekih sastojaka u pljuvački koji potiču od GT zbog njenog jednostavnijeg sakupljanja.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases
T1  - Gingivalna tečnost u dijagnostikovanju parodontopatije i sistemskih bolesti
VL  - 137
IS  - 5-6
SP  - 298
EP  - 303
DO  - 10.2298/SARH0906298C
ER  - 

@article{
author = "Čakić, Saša",
year = "2009",
abstract = "Gingival crevicular fluid (GCF) can be found in the physiologic space (gingival sulcus), as well as in the pathological space (gingival pocket or periodontal pocket) between the gums and teeth. In the first case it is a transudate, in the second an exudate. The constituents of GCF originate from serum, gingival tissues, and from both bacterial and host response cells present in the aforementioned spaces and the surrounding tissues. The collection and analysis of GCF are the noninvasive methods for the evaluation of host response in periodontal disease. These analyses mainly focus on inflammatory markers, such as prostaglandin E2, neutrophil elastase and β-glucuronidase, and on the marker of cellular necrosis - aspartat aminotransferase. Further, the analysis of inflammatory markers in the GCF may assist in defining how certain systemic diseases (e.g., diabetes mellitus) can modify periodontal disease, and how peridontal disease can influence certain systemic disorders (atherosclerosis, preterm delivery, diabetes mellitus and some chronic respiratory diseases). Major factors which influence the results obtained from the analyses of GCF are not only the methods of these analyses, but the method of GCF collection as well. As saliva collection is less technique-sensitive than GCF collection, some constituents of saliva which originate from the GCF can be analyzed as more amenable to chairside utilization., Gingivalna tečnost (GT) je tečnost koja se nalazi u fiziološkom (gingivalni sulkus) ili u patološkom prostoru između desni i zuba (gingivalni xep ili parodontalni xep). Ona može da bude transudat seruma ili inflamatorni eksudat. Elementi GT potiču iz seruma, epitela i vezivnog tkiva gingive, kao i iz inflamatornih ćelija i bakterija koje se nalaze u tom prostoru i okolnim tkivima. Prikupljanje i analiza GT je neinvazivna metoda procene odgovora osobe obolele od parodontopatije. Ove analize se uglavnom odnose na pokazatelje zapaljenja, kao što su prostaglandin E2, elastaza neutrofila i beta-glukuronidaza, ili na pokazatelj nekroze ćelija, aspartat- aminotransferazu. Osim toga, analiza pokazatelja zapaljenja u GT mogla bi da pomogne u razjašnjenju načina na koji neke sistemske bolesti (npr. diabetes mellitus) menjaju kliničku sliku parodontopatije s jedne strane, i kako zapaljenje parodoncijuma, tj. parodontopatija, može da utiče na razvoj nekih sistemskih bolesti (kardiovaskularnih, cerebrovaskularnih) sa druge. Važni činioci koji utiču na rezultate analiza GT su ne samo metode tih analiza, već i metode prikupljanja GT. Praktični razlozi upućuju i na analizu nekih sastojaka u pljuvački koji potiču od GT zbog njenog jednostavnijeg sakupljanja.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases, Gingivalna tečnost u dijagnostikovanju parodontopatije i sistemskih bolesti",
volume = "137",
number = "5-6",
pages = "298-303",
doi = "10.2298/SARH0906298C"
}

Čakić, S.. (2009). Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 137(5-6), 298-303.
https://doi.org/10.2298/SARH0906298C

Čakić S. Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases. in Srpski arhiv za celokupno lekarstvo. 2009;137(5-6):298-303.
doi:10.2298/SARH0906298C .

Čakić, Saša, "Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases" in Srpski arhiv za celokupno lekarstvo, 137, no. 5-6 (2009):298-303,
https://doi.org/10.2298/SARH0906298C . .