TY  - JOUR
AU  - Milošević-Marković, Maja
AU  - Lazarević, Miloš
AU  - Toljić, Boško
AU  - Petrović, Milan
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Aničić, Boban
AU  - Jelovac, Drago
AU  - Jovanović, Svetlana
AU  - Milašin, Jelena
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3283
AB  - Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.
PB  - TECH SCIENCE PRESS
T2  - BIOCELL
T1  - Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential
VL  - 45
IS  - 6
SP  - 1543
EP  - 1550
DO  - 10.32604/biocell.2021.015060
ER  - 

@article{
author = "Milošević-Marković, Maja and Lazarević, Miloš and Toljić, Boško and Petrović, Milan and Vukadinović, Miroslav and Jezdić, Zoran and Aničić, Boban and Jelovac, Drago and Jovanović, Svetlana and Milašin, Jelena",
year = "2021",
abstract = "Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.",
publisher = "TECH SCIENCE PRESS",
journal = "BIOCELL",
title = "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential",
volume = "45",
number = "6",
pages = "1543-1550",
doi = "10.32604/biocell.2021.015060"
}

Milošević-Marković, M., Lazarević, M., Toljić, B., Petrović, M., Vukadinović, M., Jezdić, Z., Aničić, B., Jelovac, D., Jovanović, S.,& Milašin, J.. (2021). Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential. in BIOCELL
TECH SCIENCE PRESS., 45(6), 1543-1550.
https://doi.org/10.32604/biocell.2021.015060

Milošević-Marković M, Lazarević M, Toljić B, Petrović M, Vukadinović M, Jezdić Z, Aničić B, Jelovac D, Jovanović S, Milašin J. Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential. in BIOCELL. 2021;45(6):1543-1550.
doi:10.32604/biocell.2021.015060 .

Milošević-Marković, Maja, Lazarević, Miloš, Toljić, Boško, Petrović, Milan, Vukadinović, Miroslav, Jezdić, Zoran, Aničić, Boban, Jelovac, Drago, Jovanović, Svetlana, Milašin, Jelena, "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential" in BIOCELL, 45, no. 6 (2021):1543-1550,
https://doi.org/10.32604/biocell.2021.015060 . .

TY  - JOUR
AU  - Brucoli, Matteo
AU  - Boffano, Paolo
AU  - Romeo, Irene
AU  - Corio, Chiara
AU  - Benech, Arnaldo
AU  - Ruslin, Muhammad
AU  - Forouzanfar, Tymour
AU  - Starch-Jensen, Thomas
AU  - Rodriguez-Santamarta, Tania
AU  - de Vicente, Juan Carlos
AU  - Snall, Johanna
AU  - Thoren, Hanna
AU  - Tarle, Marko
AU  - Dediol, Emil
AU  - Pechalova, Petia
AU  - Pavlov, Nikolai
AU  - Daskalov, Hristo
AU  - Doykova, Iva
AU  - Kelemith, Kadri
AU  - Tamme, Tiia
AU  - Kopchak, Andrey
AU  - Shumynskyi, Ievgen
AU  - Corre, Pierre
AU  - Bertin, Helios
AU  - Goguet, Quentin
AU  - Anquetil, Marine
AU  - Louvrier, Aurelien
AU  - Meyer, Christophe
AU  - Dovšak, Tadej
AU  - Vozlić, David
AU  - Birk, Anze
AU  - Aničić, Boban
AU  - Konstantinović, Vitomir
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2528
AB  - Background/Aims Management of maxillofacial trauma in the geriatric population poses a great challenge due to anatomical variations and medical comorbidities. The aim of this study was to analyze the management variables, timing, and outcomes of facial fractures in elderly patients (aged 70 years or more) at several European departments of oral and maxillofacial surgery. Materials and Methods This study was based on a systematic computer-assisted database that allowed the recording of data from all geriatric patients with facial fractures from the involved maxillofacial surgical units across Europe between 2013 and 2017. Results A total of 1334 patients were included in the study: 665 patients underwent closed or open surgical treatment. A significant association (P  lt  .005) was found between the presence of concomitant injuries and a prolonged time between hospital admission and treatment. The absence of indications to treatment was associated with comorbidities and an older age (P  lt  .000005). Conclusions Elderly patients require specific attention and multidisciplinary collaboration in the diagnosis and sequencing of trauma treatment. A prudent attitude may be kept in selected cases, especially when severe comorbidities are associated and function is not impaired.
PB  - Wiley, Hoboken
T2  - Dental Traumatology
T1  - Management of maxillofacial trauma in the elderly: A European multicenter study
VL  - 36
IS  - 3
SP  - 241
EP  - 246
DO  - 10.1111/edt.12536
ER  - 

@article{
author = "Brucoli, Matteo and Boffano, Paolo and Romeo, Irene and Corio, Chiara and Benech, Arnaldo and Ruslin, Muhammad and Forouzanfar, Tymour and Starch-Jensen, Thomas and Rodriguez-Santamarta, Tania and de Vicente, Juan Carlos and Snall, Johanna and Thoren, Hanna and Tarle, Marko and Dediol, Emil and Pechalova, Petia and Pavlov, Nikolai and Daskalov, Hristo and Doykova, Iva and Kelemith, Kadri and Tamme, Tiia and Kopchak, Andrey and Shumynskyi, Ievgen and Corre, Pierre and Bertin, Helios and Goguet, Quentin and Anquetil, Marine and Louvrier, Aurelien and Meyer, Christophe and Dovšak, Tadej and Vozlić, David and Birk, Anze and Aničić, Boban and Konstantinović, Vitomir",
year = "2020",
abstract = "Background/Aims Management of maxillofacial trauma in the geriatric population poses a great challenge due to anatomical variations and medical comorbidities. The aim of this study was to analyze the management variables, timing, and outcomes of facial fractures in elderly patients (aged 70 years or more) at several European departments of oral and maxillofacial surgery. Materials and Methods This study was based on a systematic computer-assisted database that allowed the recording of data from all geriatric patients with facial fractures from the involved maxillofacial surgical units across Europe between 2013 and 2017. Results A total of 1334 patients were included in the study: 665 patients underwent closed or open surgical treatment. A significant association (P  lt  .005) was found between the presence of concomitant injuries and a prolonged time between hospital admission and treatment. The absence of indications to treatment was associated with comorbidities and an older age (P  lt  .000005). Conclusions Elderly patients require specific attention and multidisciplinary collaboration in the diagnosis and sequencing of trauma treatment. A prudent attitude may be kept in selected cases, especially when severe comorbidities are associated and function is not impaired.",
publisher = "Wiley, Hoboken",
journal = "Dental Traumatology",
title = "Management of maxillofacial trauma in the elderly: A European multicenter study",
volume = "36",
number = "3",
pages = "241-246",
doi = "10.1111/edt.12536"
}

Brucoli, M., Boffano, P., Romeo, I., Corio, C., Benech, A., Ruslin, M., Forouzanfar, T., Starch-Jensen, T., Rodriguez-Santamarta, T., de Vicente, J. C., Snall, J., Thoren, H., Tarle, M., Dediol, E., Pechalova, P., Pavlov, N., Daskalov, H., Doykova, I., Kelemith, K., Tamme, T., Kopchak, A., Shumynskyi, I., Corre, P., Bertin, H., Goguet, Q., Anquetil, M., Louvrier, A., Meyer, C., Dovšak, T., Vozlić, D., Birk, A., Aničić, B.,& Konstantinović, V.. (2020). Management of maxillofacial trauma in the elderly: A European multicenter study. in Dental Traumatology
Wiley, Hoboken., 36(3), 241-246.
https://doi.org/10.1111/edt.12536

Brucoli M, Boffano P, Romeo I, Corio C, Benech A, Ruslin M, Forouzanfar T, Starch-Jensen T, Rodriguez-Santamarta T, de Vicente JC, Snall J, Thoren H, Tarle M, Dediol E, Pechalova P, Pavlov N, Daskalov H, Doykova I, Kelemith K, Tamme T, Kopchak A, Shumynskyi I, Corre P, Bertin H, Goguet Q, Anquetil M, Louvrier A, Meyer C, Dovšak T, Vozlić D, Birk A, Aničić B, Konstantinović V. Management of maxillofacial trauma in the elderly: A European multicenter study. in Dental Traumatology. 2020;36(3):241-246.
doi:10.1111/edt.12536 .

Brucoli, Matteo, Boffano, Paolo, Romeo, Irene, Corio, Chiara, Benech, Arnaldo, Ruslin, Muhammad, Forouzanfar, Tymour, Starch-Jensen, Thomas, Rodriguez-Santamarta, Tania, de Vicente, Juan Carlos, Snall, Johanna, Thoren, Hanna, Tarle, Marko, Dediol, Emil, Pechalova, Petia, Pavlov, Nikolai, Daskalov, Hristo, Doykova, Iva, Kelemith, Kadri, Tamme, Tiia, Kopchak, Andrey, Shumynskyi, Ievgen, Corre, Pierre, Bertin, Helios, Goguet, Quentin, Anquetil, Marine, Louvrier, Aurelien, Meyer, Christophe, Dovšak, Tadej, Vozlić, David, Birk, Anze, Aničić, Boban, Konstantinović, Vitomir, "Management of maxillofacial trauma in the elderly: A European multicenter study" in Dental Traumatology, 36, no. 3 (2020):241-246,
https://doi.org/10.1111/edt.12536 . .

TY  - JOUR
AU  - Brucoli, Matteo
AU  - Boffano, Paolo
AU  - Romeo, Irene
AU  - Corio, Chiara
AU  - Benech, Arnaldo
AU  - Ruslin, Muhammad
AU  - Forouzanfar, Tymour
AU  - Rodriguez-Santamarta, Tania
AU  - Vicente, Juan Carlos de
AU  - Tarle, Marko
AU  - Dediol, Emil
AU  - Pechalova, Petia
AU  - Pavlov, Nikolai
AU  - Daskalov, Hristo
AU  - Doykova, Iva
AU  - Kelemith, Kadri
AU  - Tamme, Tiia
AU  - Kopchak, Andrey
AU  - Shumynskyi, Ievgen
AU  - Corre, Pierre
AU  - Bertin, Helios
AU  - Bourry, Maeva
AU  - Guyonvarc'h, Pierre
AU  - Dovšak, Tadej
AU  - Vozlić, David
AU  - Birk, Anze
AU  - Aničić, Boban
AU  - Konstantinović, Vitomir
AU  - Starch-Jensen, Thomas
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2515
AB  - Introduction Management of body fractures in patients with edentulous atrophic mandibles represents a challenging task due to patient's age, medical comorbidities, poor bone quality, and vascularity, as well as reduced contact area between the fracture ends. The aim of the study was to assess the demographic and clinical variables, the surgical technique, and outcomes of unilateral body fractures of the edentulous atrophic mandible managed at several European departments of oral and maxillofacial surgery. Methods This study is based on a systematic computer-assisted database that allowed the recording of data of all patients with fractures of the atrophic edentulous mandible from the involved maxillofacial surgical units across Europe between 2008 and 2017. The following data were recorded for each patient: gender, age, comorbidities, etiology, synchronous body injuries, degree of atrophy of the mandible according to Luhr classification, type of surgical approach and fixation, length of hospitalization, and presence and type of complications. Results A total of 43 patients were included in the study: 17 patients' mandibles were classified as class I according to Luhr, 15 as class II, and 11 as class III. All patients underwent open reduction and internal fixation by extraoral approach in 25 patients, intraoral in 15 patients, and mixed in 3 patients. A single 2.0 miniplate was used in 16 patients, followed by a single 2.4 reconstruction plate in 13 patients, by two 2.0 miniplates, and three 2.0 miniplates. Outcome was considered to be satisfying in 30 patients, with no complications. Complications were observed in 13 cases. Conclusions Treatment of unilateral body fractures of the edentulous mandible must still be based on the type of fracture, degree of atrophy, experience of the surgeon, and patients' preference. An adequate stability can be obtained by different plating techniques that have to be appropriately tailored to every single specific patient.
PB  - Springer Heidelberg, Heidelberg
T2  - Oral & Maxillofacial Surgery-Heidelberg
T1  - Surgical management of unilateral body fractures of the edentulous atrophic mandible
VL  - 24
IS  - 1
SP  - 65
EP  - 71
DO  - 10.1007/s10006-019-00824-8
ER  - 

@article{
author = "Brucoli, Matteo and Boffano, Paolo and Romeo, Irene and Corio, Chiara and Benech, Arnaldo and Ruslin, Muhammad and Forouzanfar, Tymour and Rodriguez-Santamarta, Tania and Vicente, Juan Carlos de and Tarle, Marko and Dediol, Emil and Pechalova, Petia and Pavlov, Nikolai and Daskalov, Hristo and Doykova, Iva and Kelemith, Kadri and Tamme, Tiia and Kopchak, Andrey and Shumynskyi, Ievgen and Corre, Pierre and Bertin, Helios and Bourry, Maeva and Guyonvarc'h, Pierre and Dovšak, Tadej and Vozlić, David and Birk, Anze and Aničić, Boban and Konstantinović, Vitomir and Starch-Jensen, Thomas",
year = "2020",
abstract = "Introduction Management of body fractures in patients with edentulous atrophic mandibles represents a challenging task due to patient's age, medical comorbidities, poor bone quality, and vascularity, as well as reduced contact area between the fracture ends. The aim of the study was to assess the demographic and clinical variables, the surgical technique, and outcomes of unilateral body fractures of the edentulous atrophic mandible managed at several European departments of oral and maxillofacial surgery. Methods This study is based on a systematic computer-assisted database that allowed the recording of data of all patients with fractures of the atrophic edentulous mandible from the involved maxillofacial surgical units across Europe between 2008 and 2017. The following data were recorded for each patient: gender, age, comorbidities, etiology, synchronous body injuries, degree of atrophy of the mandible according to Luhr classification, type of surgical approach and fixation, length of hospitalization, and presence and type of complications. Results A total of 43 patients were included in the study: 17 patients' mandibles were classified as class I according to Luhr, 15 as class II, and 11 as class III. All patients underwent open reduction and internal fixation by extraoral approach in 25 patients, intraoral in 15 patients, and mixed in 3 patients. A single 2.0 miniplate was used in 16 patients, followed by a single 2.4 reconstruction plate in 13 patients, by two 2.0 miniplates, and three 2.0 miniplates. Outcome was considered to be satisfying in 30 patients, with no complications. Complications were observed in 13 cases. Conclusions Treatment of unilateral body fractures of the edentulous mandible must still be based on the type of fracture, degree of atrophy, experience of the surgeon, and patients' preference. An adequate stability can be obtained by different plating techniques that have to be appropriately tailored to every single specific patient.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Oral & Maxillofacial Surgery-Heidelberg",
title = "Surgical management of unilateral body fractures of the edentulous atrophic mandible",
volume = "24",
number = "1",
pages = "65-71",
doi = "10.1007/s10006-019-00824-8"
}

Brucoli, M., Boffano, P., Romeo, I., Corio, C., Benech, A., Ruslin, M., Forouzanfar, T., Rodriguez-Santamarta, T., Vicente, J. C. d., Tarle, M., Dediol, E., Pechalova, P., Pavlov, N., Daskalov, H., Doykova, I., Kelemith, K., Tamme, T., Kopchak, A., Shumynskyi, I., Corre, P., Bertin, H., Bourry, M., Guyonvarc'h, P., Dovšak, T., Vozlić, D., Birk, A., Aničić, B., Konstantinović, V.,& Starch-Jensen, T.. (2020). Surgical management of unilateral body fractures of the edentulous atrophic mandible. in Oral & Maxillofacial Surgery-Heidelberg
Springer Heidelberg, Heidelberg., 24(1), 65-71.
https://doi.org/10.1007/s10006-019-00824-8

Brucoli M, Boffano P, Romeo I, Corio C, Benech A, Ruslin M, Forouzanfar T, Rodriguez-Santamarta T, Vicente JCD, Tarle M, Dediol E, Pechalova P, Pavlov N, Daskalov H, Doykova I, Kelemith K, Tamme T, Kopchak A, Shumynskyi I, Corre P, Bertin H, Bourry M, Guyonvarc'h P, Dovšak T, Vozlić D, Birk A, Aničić B, Konstantinović V, Starch-Jensen T. Surgical management of unilateral body fractures of the edentulous atrophic mandible. in Oral & Maxillofacial Surgery-Heidelberg. 2020;24(1):65-71.
doi:10.1007/s10006-019-00824-8 .

Brucoli, Matteo, Boffano, Paolo, Romeo, Irene, Corio, Chiara, Benech, Arnaldo, Ruslin, Muhammad, Forouzanfar, Tymour, Rodriguez-Santamarta, Tania, Vicente, Juan Carlos de, Tarle, Marko, Dediol, Emil, Pechalova, Petia, Pavlov, Nikolai, Daskalov, Hristo, Doykova, Iva, Kelemith, Kadri, Tamme, Tiia, Kopchak, Andrey, Shumynskyi, Ievgen, Corre, Pierre, Bertin, Helios, Bourry, Maeva, Guyonvarc'h, Pierre, Dovšak, Tadej, Vozlić, David, Birk, Anze, Aničić, Boban, Konstantinović, Vitomir, Starch-Jensen, Thomas, "Surgical management of unilateral body fractures of the edentulous atrophic mandible" in Oral & Maxillofacial Surgery-Heidelberg, 24, no. 1 (2020):65-71,
https://doi.org/10.1007/s10006-019-00824-8 . .

TY  - JOUR
AU  - Brucoli, Matteo
AU  - Boffano, Paolo
AU  - Romeo, Irene
AU  - Corio, Chiara
AU  - Benech, Arnaldo
AU  - Ruslin, Muhammad
AU  - Forouzanfar, Tymour
AU  - Starch-Jensen, Thomas
AU  - Rodriguez-Santamarta, Tania
AU  - de Vicente, Juan Carlos
AU  - Snall, Johanna
AU  - Thoren, Hanna
AU  - Tarle, Marko
AU  - Dediol, Emil
AU  - Pechalova, Petia
AU  - Pavlov, Nikolai
AU  - Daskalov, Hristo
AU  - Doykova, Iva
AU  - Kelemith, Kadri
AU  - Tamme, Tiia
AU  - Kopchak, Andrey
AU  - Shumynskyi, Ievgen
AU  - Corre, Pierre
AU  - Bertin, Helios
AU  - Goguet, Quentin
AU  - Anquetil, Marine
AU  - Louvrier, Aurelien
AU  - Meyer, Christophe
AU  - Dovšak, Tadej
AU  - Vozlić, David
AU  - Birk, Anze
AU  - Aničić, Boban
AU  - Konstantinović, Vitomir
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2500
AB  - Background/Aims Management of maxillofacial trauma in the geriatric population poses a great challenge due to anatomical variations and medical comorbidities. The aim of this study was to analyze the management variables, timing, and outcomes of facial fractures in elderly patients (aged 70 years or more) at several European departments of oral and maxillofacial surgery. Materials and Methods This study was based on a systematic computer-assisted database that allowed the recording of data from all geriatric patients with facial fractures from the involved maxillofacial surgical units across Europe between 2013 and 2017. Results A total of 1334 patients were included in the study: 665 patients underwent closed or open surgical treatment. A significant association (P  lt  .005) was found between the presence of concomitant injuries and a prolonged time between hospital admission and treatment. The absence of indications to treatment was associated with comorbidities and an older age (P  lt  .000005). Conclusions Elderly patients require specific attention and multidisciplinary collaboration in the diagnosis and sequencing of trauma treatment. A prudent attitude may be kept in selected cases, especially when severe comorbidities are associated and function is not impaired.
PB  - Wiley, Hoboken
T2  - Dental Traumatology
T1  - Management of maxillofacial trauma in the elderly: A European multicenter study
VL  - 36
IS  - 3
SP  - 241
EP  - 246
DO  - 10.1111/edt.12536
ER  - 

@article{
author = "Brucoli, Matteo and Boffano, Paolo and Romeo, Irene and Corio, Chiara and Benech, Arnaldo and Ruslin, Muhammad and Forouzanfar, Tymour and Starch-Jensen, Thomas and Rodriguez-Santamarta, Tania and de Vicente, Juan Carlos and Snall, Johanna and Thoren, Hanna and Tarle, Marko and Dediol, Emil and Pechalova, Petia and Pavlov, Nikolai and Daskalov, Hristo and Doykova, Iva and Kelemith, Kadri and Tamme, Tiia and Kopchak, Andrey and Shumynskyi, Ievgen and Corre, Pierre and Bertin, Helios and Goguet, Quentin and Anquetil, Marine and Louvrier, Aurelien and Meyer, Christophe and Dovšak, Tadej and Vozlić, David and Birk, Anze and Aničić, Boban and Konstantinović, Vitomir",
year = "2020",
abstract = "Background/Aims Management of maxillofacial trauma in the geriatric population poses a great challenge due to anatomical variations and medical comorbidities. The aim of this study was to analyze the management variables, timing, and outcomes of facial fractures in elderly patients (aged 70 years or more) at several European departments of oral and maxillofacial surgery. Materials and Methods This study was based on a systematic computer-assisted database that allowed the recording of data from all geriatric patients with facial fractures from the involved maxillofacial surgical units across Europe between 2013 and 2017. Results A total of 1334 patients were included in the study: 665 patients underwent closed or open surgical treatment. A significant association (P  lt  .005) was found between the presence of concomitant injuries and a prolonged time between hospital admission and treatment. The absence of indications to treatment was associated with comorbidities and an older age (P  lt  .000005). Conclusions Elderly patients require specific attention and multidisciplinary collaboration in the diagnosis and sequencing of trauma treatment. A prudent attitude may be kept in selected cases, especially when severe comorbidities are associated and function is not impaired.",
publisher = "Wiley, Hoboken",
journal = "Dental Traumatology",
title = "Management of maxillofacial trauma in the elderly: A European multicenter study",
volume = "36",
number = "3",
pages = "241-246",
doi = "10.1111/edt.12536"
}

Brucoli, M., Boffano, P., Romeo, I., Corio, C., Benech, A., Ruslin, M., Forouzanfar, T., Starch-Jensen, T., Rodriguez-Santamarta, T., de Vicente, J. C., Snall, J., Thoren, H., Tarle, M., Dediol, E., Pechalova, P., Pavlov, N., Daskalov, H., Doykova, I., Kelemith, K., Tamme, T., Kopchak, A., Shumynskyi, I., Corre, P., Bertin, H., Goguet, Q., Anquetil, M., Louvrier, A., Meyer, C., Dovšak, T., Vozlić, D., Birk, A., Aničić, B.,& Konstantinović, V.. (2020). Management of maxillofacial trauma in the elderly: A European multicenter study. in Dental Traumatology
Wiley, Hoboken., 36(3), 241-246.
https://doi.org/10.1111/edt.12536

Brucoli M, Boffano P, Romeo I, Corio C, Benech A, Ruslin M, Forouzanfar T, Starch-Jensen T, Rodriguez-Santamarta T, de Vicente JC, Snall J, Thoren H, Tarle M, Dediol E, Pechalova P, Pavlov N, Daskalov H, Doykova I, Kelemith K, Tamme T, Kopchak A, Shumynskyi I, Corre P, Bertin H, Goguet Q, Anquetil M, Louvrier A, Meyer C, Dovšak T, Vozlić D, Birk A, Aničić B, Konstantinović V. Management of maxillofacial trauma in the elderly: A European multicenter study. in Dental Traumatology. 2020;36(3):241-246.
doi:10.1111/edt.12536 .

Brucoli, Matteo, Boffano, Paolo, Romeo, Irene, Corio, Chiara, Benech, Arnaldo, Ruslin, Muhammad, Forouzanfar, Tymour, Starch-Jensen, Thomas, Rodriguez-Santamarta, Tania, de Vicente, Juan Carlos, Snall, Johanna, Thoren, Hanna, Tarle, Marko, Dediol, Emil, Pechalova, Petia, Pavlov, Nikolai, Daskalov, Hristo, Doykova, Iva, Kelemith, Kadri, Tamme, Tiia, Kopchak, Andrey, Shumynskyi, Ievgen, Corre, Pierre, Bertin, Helios, Goguet, Quentin, Anquetil, Marine, Louvrier, Aurelien, Meyer, Christophe, Dovšak, Tadej, Vozlić, David, Birk, Anze, Aničić, Boban, Konstantinović, Vitomir, "Management of maxillofacial trauma in the elderly: A European multicenter study" in Dental Traumatology, 36, no. 3 (2020):241-246,
https://doi.org/10.1111/edt.12536 . .

TY  - JOUR
AU  - Brucoli, Matteo
AU  - Boffano, Paolo
AU  - Romeo, Irene
AU  - Corio, Chiara
AU  - Benech, Arnaldo
AU  - Ruslin, Muhammad
AU  - Forouzanfar, Tymour
AU  - Rodriguez-Santamarta, Tania
AU  - de Vicente, Juan Carlos
AU  - Tarle, Marko
AU  - Dediol, Emil
AU  - Pechalova, Petia
AU  - Pavlov, Nikolai
AU  - Daskalov, Hristo
AU  - Doykova, Iva
AU  - Kelemith, Kadri
AU  - Tamme, Tiia
AU  - Kopchak, Andrey
AU  - Shumynskyi, Ievgen
AU  - Corre, Pierre
AU  - Bertin, Helios
AU  - Bourry, Maeva
AU  - Guyonvarc'h, Pierre
AU  - Dovšak, Tadej
AU  - Vozlić, David
AU  - Birk, Anze
AU  - Aničić, Boban
AU  - Konstantinović, Vitomir
AU  - Starch-Jensen, Thomas
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2477
AB  - Introduction: Treatment of condylar fractures in patients with atrophic edentulous mandibles is a peculiar field that has been little considered in the literature. The aim of the study was to assess the demographic and clinical variables as well as management and outcome of mandibular condylar fractures in edentulous patients with atrophic mandibles that were treated at several European departments of oral and maxillofacial surgery. Methods: The data of all patients with fractures of the atrophic edentulous mandible from the involved maxillofacial surgical units across Europe between January 1, 2008, and December 31, 2017. Only patients that were diagnosed with condylar fractures of the edentulous atrophic mandible were included. Results: A total of 52 patients met the inclusion criteria and were included in the study: 79% of patients reported one or more comorbidities. Thirty-four unilateral neck or subcondylar fractures, 9 bilateral neck or subcondylar condylar fractures, 7 unilateral head condylar fractures, and 2 bilateral head condylar fractures were diagnosed. No treatment was performed in 37 cases, whereas in 4 patients a closed treatment was decided, and 11 patients underwent open reduction and internal fixation. Outcome was considered to be satisfying in 48 patients, with no complications. Conclusions: The golden rule still remains that the diagnosis of a subcondylar or neck fracture in an edentulous patient should constitute an indication for open reduction and internal fixation. However, an appropriate choice of management options has to be individualized on a case by case basis, also depending on the patient consent.
PB  - Elsevier Masson SAS
T2  - Journal of Stomatology, Oral & Maxillofacial Surgery
T1  - Management of mandibular condylar fractures in patients with atrophic edentulous mandibles
VL  - 121
IS  - 3
SP  - 226
EP  - 232
DO  - 10.1016/j.jormas.2019.10.004
ER  - 

@article{
author = "Brucoli, Matteo and Boffano, Paolo and Romeo, Irene and Corio, Chiara and Benech, Arnaldo and Ruslin, Muhammad and Forouzanfar, Tymour and Rodriguez-Santamarta, Tania and de Vicente, Juan Carlos and Tarle, Marko and Dediol, Emil and Pechalova, Petia and Pavlov, Nikolai and Daskalov, Hristo and Doykova, Iva and Kelemith, Kadri and Tamme, Tiia and Kopchak, Andrey and Shumynskyi, Ievgen and Corre, Pierre and Bertin, Helios and Bourry, Maeva and Guyonvarc'h, Pierre and Dovšak, Tadej and Vozlić, David and Birk, Anze and Aničić, Boban and Konstantinović, Vitomir and Starch-Jensen, Thomas",
year = "2020",
abstract = "Introduction: Treatment of condylar fractures in patients with atrophic edentulous mandibles is a peculiar field that has been little considered in the literature. The aim of the study was to assess the demographic and clinical variables as well as management and outcome of mandibular condylar fractures in edentulous patients with atrophic mandibles that were treated at several European departments of oral and maxillofacial surgery. Methods: The data of all patients with fractures of the atrophic edentulous mandible from the involved maxillofacial surgical units across Europe between January 1, 2008, and December 31, 2017. Only patients that were diagnosed with condylar fractures of the edentulous atrophic mandible were included. Results: A total of 52 patients met the inclusion criteria and were included in the study: 79% of patients reported one or more comorbidities. Thirty-four unilateral neck or subcondylar fractures, 9 bilateral neck or subcondylar condylar fractures, 7 unilateral head condylar fractures, and 2 bilateral head condylar fractures were diagnosed. No treatment was performed in 37 cases, whereas in 4 patients a closed treatment was decided, and 11 patients underwent open reduction and internal fixation. Outcome was considered to be satisfying in 48 patients, with no complications. Conclusions: The golden rule still remains that the diagnosis of a subcondylar or neck fracture in an edentulous patient should constitute an indication for open reduction and internal fixation. However, an appropriate choice of management options has to be individualized on a case by case basis, also depending on the patient consent.",
publisher = "Elsevier Masson SAS",
journal = "Journal of Stomatology, Oral & Maxillofacial Surgery",
title = "Management of mandibular condylar fractures in patients with atrophic edentulous mandibles",
volume = "121",
number = "3",
pages = "226-232",
doi = "10.1016/j.jormas.2019.10.004"
}

Brucoli, M., Boffano, P., Romeo, I., Corio, C., Benech, A., Ruslin, M., Forouzanfar, T., Rodriguez-Santamarta, T., de Vicente, J. C., Tarle, M., Dediol, E., Pechalova, P., Pavlov, N., Daskalov, H., Doykova, I., Kelemith, K., Tamme, T., Kopchak, A., Shumynskyi, I., Corre, P., Bertin, H., Bourry, M., Guyonvarc'h, P., Dovšak, T., Vozlić, D., Birk, A., Aničić, B., Konstantinović, V.,& Starch-Jensen, T.. (2020). Management of mandibular condylar fractures in patients with atrophic edentulous mandibles. in Journal of Stomatology, Oral & Maxillofacial Surgery
Elsevier Masson SAS., 121(3), 226-232.
https://doi.org/10.1016/j.jormas.2019.10.004

Brucoli M, Boffano P, Romeo I, Corio C, Benech A, Ruslin M, Forouzanfar T, Rodriguez-Santamarta T, de Vicente JC, Tarle M, Dediol E, Pechalova P, Pavlov N, Daskalov H, Doykova I, Kelemith K, Tamme T, Kopchak A, Shumynskyi I, Corre P, Bertin H, Bourry M, Guyonvarc'h P, Dovšak T, Vozlić D, Birk A, Aničić B, Konstantinović V, Starch-Jensen T. Management of mandibular condylar fractures in patients with atrophic edentulous mandibles. in Journal of Stomatology, Oral & Maxillofacial Surgery. 2020;121(3):226-232.
doi:10.1016/j.jormas.2019.10.004 .

Brucoli, Matteo, Boffano, Paolo, Romeo, Irene, Corio, Chiara, Benech, Arnaldo, Ruslin, Muhammad, Forouzanfar, Tymour, Rodriguez-Santamarta, Tania, de Vicente, Juan Carlos, Tarle, Marko, Dediol, Emil, Pechalova, Petia, Pavlov, Nikolai, Daskalov, Hristo, Doykova, Iva, Kelemith, Kadri, Tamme, Tiia, Kopchak, Andrey, Shumynskyi, Ievgen, Corre, Pierre, Bertin, Helios, Bourry, Maeva, Guyonvarc'h, Pierre, Dovšak, Tadej, Vozlić, David, Birk, Anze, Aničić, Boban, Konstantinović, Vitomir, Starch-Jensen, Thomas, "Management of mandibular condylar fractures in patients with atrophic edentulous mandibles" in Journal of Stomatology, Oral & Maxillofacial Surgery, 121, no. 3 (2020):226-232,
https://doi.org/10.1016/j.jormas.2019.10.004 . .

TY  - JOUR
AU  - Brucoli, Matteo
AU  - Boffano, Paolo
AU  - Romeo, Irene
AU  - Corio, Chiara
AU  - Benech, Arnaldo
AU  - Ruslin, Muhammad
AU  - Forouzanfar, Tymour
AU  - Starch-Jensen, Thomas
AU  - Rodriguez-Santamarta, Tania
AU  - de Vicente, Juan Carlos
AU  - Snäll, J.
AU  - Thoren, Hanna
AU  - Aničić, Boban
AU  - Konstantinović, Vitomir
AU  - Pechalova, Petia
AU  - Pavlov, Nikolai
AU  - Daskalov, Hristo
AU  - Doykova, Iva
AU  - Kelemith, Kadri
AU  - Tamme, Tiia
AU  - Kopchak, Andrey
AU  - Shumynskyi, Ievgen
AU  - Corre, Pierre
AU  - Bertin, Helios
AU  - Goguet, Quentin
AU  - Anquetil, Marine
AU  - Louvrier, Aurelien
AU  - Meyer, Christophe
AU  - Dovšak, Tadej
AU  - Vozlić, David
AU  - Birk, Anze
AU  - Tarle, Marko
AU  - Dediol, Emil
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2425
AB  - Introduction: The progressive aging of European population seems to determine a change in the epidemiology, incidence and etiology of maxillofacial fractures with an increase in the frequency of old patients sustaining craniofacial trauma. The objective of the present study was to assess the demographic variables, causes, and patterns of facial fractures in elderly population (with 70 years or more). Materials and methods: The data from all geriatric patients (70 years or more) with facial fractures between January 1, 2013, and December 31, 2017, were collected. The following data were recorded for each patient: gender, age, voluptuary habits, comorbidities, etiology, site of facial fractures, synchronous body injuries, Facial Injury Severity Score (FISS). Results: A total of 1334 patients (599 male and 735 female patients) were included in the study. Mean age was 79.3 years, and 66% of patients reported one or more comorbidities. The most frequent cause of injury was fall and zygomatic fractures were the most frequently observed injuries. Falls were associated with a low FISS value (P  lt  .005). Concomitant injuries were observed in 27.3% of patients. Falls were associated with the absence of concomitant injuries. The ninth decade (P  lt  .05) and a high FISS score (P  lt  .005) were associated with concomitant body injuries too. Conclusions: This study confirms the role of falls in the epidemiology of facial trauma in the elderly, but also highlights the frequency of involvement of females, and the high frequency of zygomatic fractures.
PB  - Elsevier Masson SAS
T2  - Journal of Stomatology, Oral & Maxillofacial Surgery
T1  - Epidemiology of maxillofacial trauma in the elderly: A European multicenter study
DO  - 10.1016/j.jormas.2019.09.002
ER  - 

@article{
author = "Brucoli, Matteo and Boffano, Paolo and Romeo, Irene and Corio, Chiara and Benech, Arnaldo and Ruslin, Muhammad and Forouzanfar, Tymour and Starch-Jensen, Thomas and Rodriguez-Santamarta, Tania and de Vicente, Juan Carlos and Snäll, J. and Thoren, Hanna and Aničić, Boban and Konstantinović, Vitomir and Pechalova, Petia and Pavlov, Nikolai and Daskalov, Hristo and Doykova, Iva and Kelemith, Kadri and Tamme, Tiia and Kopchak, Andrey and Shumynskyi, Ievgen and Corre, Pierre and Bertin, Helios and Goguet, Quentin and Anquetil, Marine and Louvrier, Aurelien and Meyer, Christophe and Dovšak, Tadej and Vozlić, David and Birk, Anze and Tarle, Marko and Dediol, Emil",
year = "2019",
abstract = "Introduction: The progressive aging of European population seems to determine a change in the epidemiology, incidence and etiology of maxillofacial fractures with an increase in the frequency of old patients sustaining craniofacial trauma. The objective of the present study was to assess the demographic variables, causes, and patterns of facial fractures in elderly population (with 70 years or more). Materials and methods: The data from all geriatric patients (70 years or more) with facial fractures between January 1, 2013, and December 31, 2017, were collected. The following data were recorded for each patient: gender, age, voluptuary habits, comorbidities, etiology, site of facial fractures, synchronous body injuries, Facial Injury Severity Score (FISS). Results: A total of 1334 patients (599 male and 735 female patients) were included in the study. Mean age was 79.3 years, and 66% of patients reported one or more comorbidities. The most frequent cause of injury was fall and zygomatic fractures were the most frequently observed injuries. Falls were associated with a low FISS value (P  lt  .005). Concomitant injuries were observed in 27.3% of patients. Falls were associated with the absence of concomitant injuries. The ninth decade (P  lt  .05) and a high FISS score (P  lt  .005) were associated with concomitant body injuries too. Conclusions: This study confirms the role of falls in the epidemiology of facial trauma in the elderly, but also highlights the frequency of involvement of females, and the high frequency of zygomatic fractures.",
publisher = "Elsevier Masson SAS",
journal = "Journal of Stomatology, Oral & Maxillofacial Surgery",
title = "Epidemiology of maxillofacial trauma in the elderly: A European multicenter study",
doi = "10.1016/j.jormas.2019.09.002"
}

Brucoli, M., Boffano, P., Romeo, I., Corio, C., Benech, A., Ruslin, M., Forouzanfar, T., Starch-Jensen, T., Rodriguez-Santamarta, T., de Vicente, J. C., Snäll, J., Thoren, H., Aničić, B., Konstantinović, V., Pechalova, P., Pavlov, N., Daskalov, H., Doykova, I., Kelemith, K., Tamme, T., Kopchak, A., Shumynskyi, I., Corre, P., Bertin, H., Goguet, Q., Anquetil, M., Louvrier, A., Meyer, C., Dovšak, T., Vozlić, D., Birk, A., Tarle, M.,& Dediol, E.. (2019). Epidemiology of maxillofacial trauma in the elderly: A European multicenter study. in Journal of Stomatology, Oral & Maxillofacial Surgery
Elsevier Masson SAS..
https://doi.org/10.1016/j.jormas.2019.09.002

Brucoli M, Boffano P, Romeo I, Corio C, Benech A, Ruslin M, Forouzanfar T, Starch-Jensen T, Rodriguez-Santamarta T, de Vicente JC, Snäll J, Thoren H, Aničić B, Konstantinović V, Pechalova P, Pavlov N, Daskalov H, Doykova I, Kelemith K, Tamme T, Kopchak A, Shumynskyi I, Corre P, Bertin H, Goguet Q, Anquetil M, Louvrier A, Meyer C, Dovšak T, Vozlić D, Birk A, Tarle M, Dediol E. Epidemiology of maxillofacial trauma in the elderly: A European multicenter study. in Journal of Stomatology, Oral & Maxillofacial Surgery. 2019;.
doi:10.1016/j.jormas.2019.09.002 .

Brucoli, Matteo, Boffano, Paolo, Romeo, Irene, Corio, Chiara, Benech, Arnaldo, Ruslin, Muhammad, Forouzanfar, Tymour, Starch-Jensen, Thomas, Rodriguez-Santamarta, Tania, de Vicente, Juan Carlos, Snäll, J., Thoren, Hanna, Aničić, Boban, Konstantinović, Vitomir, Pechalova, Petia, Pavlov, Nikolai, Daskalov, Hristo, Doykova, Iva, Kelemith, Kadri, Tamme, Tiia, Kopchak, Andrey, Shumynskyi, Ievgen, Corre, Pierre, Bertin, Helios, Goguet, Quentin, Anquetil, Marine, Louvrier, Aurelien, Meyer, Christophe, Dovšak, Tadej, Vozlić, David, Birk, Anze, Tarle, Marko, Dediol, Emil, "Epidemiology of maxillofacial trauma in the elderly: A European multicenter study" in Journal of Stomatology, Oral & Maxillofacial Surgery (2019),
https://doi.org/10.1016/j.jormas.2019.09.002 . .

TY  - JOUR
AU  - Brucoli, Matteo
AU  - Boffano, Paolo
AU  - Romeo, Irene
AU  - Corio, Chiara
AU  - Benech, Arnaldo
AU  - Ruslin, Muhammad
AU  - Forouzanfar, Tymour
AU  - Rodriguez-Santamarta, Tania
AU  - de Vicente, Juan Carlos
AU  - Tarle, Marko
AU  - Dediol, Emil
AU  - Pechalova, Petia
AU  - Pavlov, Nikolai
AU  - Daskalov, Hristo
AU  - Doykova, Iva
AU  - Kelemith, Kadri
AU  - Tamme, Tiia
AU  - Kopchak, Andrey
AU  - Shumynskyi, Ievgen
AU  - Corre, Pierre
AU  - Bertin, Helios
AU  - Bourry, Maeva
AU  - Guyonvarc'h, Pierre
AU  - Dovšak, Tadej
AU  - Vozlić, David
AU  - Birk, Anze
AU  - Aničić, Boban
AU  - Konstantinović, Vitomir
AU  - Starch-Jensen, Thomas
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2417
AB  - Introduction: The objective of the present study was to assess the demographic variables, causes, and patterns of edentulous atrophic fractures of the mandible managed at several European departments of oral and maxillofacial surgery. The results of this multicenter collaboration over a 10-year period are presented. Methods: The data of all patients with fractures of the atrophic edentulous mandible from the involved maxillofacial surgical units across Europe between January 1, 2008, and December 31, 2017 were recorded: gender; age; voluptuary habits; comorbidities; etiology; fracture sites; synchronous body injuries; atrophy of the mandible according to Luhr classification; eventual type of treatment; timing of the eventual surgery; length of hospital stay. Results: A total of 197 patients (86 male and 111 female patients) with 285 mandibular fractures were included in the study. Mean age of the study populationwas 75 years. Statistically significant associations were found between Luhr classes I - II and condylar fractures on one hand (p  lt .0005), and between Luhr class III and body and parasymphyseal fractures on the other hand (p  lt .05). Finally, 135 patients underwent open reduction and internal fixation, 56 patients did not undergo any intervention, and 6 patients underwent closed reduction. No statistically significant association was observed between treatment, timing of treatment, comorbidities, and concomitant injuries. Conclusions: The management of edentulous atrophic mandibular fractures remains challenging. Treatment decisions should continue to be based on the clinician's previous experience and on the degree of bone resorption in edentulous mandible in relation to fracture subsites.
PB  - Churchill Livingstone, Edinburgh
T2  - Journal of Cranio-Maxillofacial Surgery
T1  - The epidemiology of edentulous atrophic mandibular fractures in Europe
VL  - 47
IS  - 12
SP  - 1929
EP  - 1934
DO  - 10.1016/j.jcms.2019.11.021
ER  - 

@article{
author = "Brucoli, Matteo and Boffano, Paolo and Romeo, Irene and Corio, Chiara and Benech, Arnaldo and Ruslin, Muhammad and Forouzanfar, Tymour and Rodriguez-Santamarta, Tania and de Vicente, Juan Carlos and Tarle, Marko and Dediol, Emil and Pechalova, Petia and Pavlov, Nikolai and Daskalov, Hristo and Doykova, Iva and Kelemith, Kadri and Tamme, Tiia and Kopchak, Andrey and Shumynskyi, Ievgen and Corre, Pierre and Bertin, Helios and Bourry, Maeva and Guyonvarc'h, Pierre and Dovšak, Tadej and Vozlić, David and Birk, Anze and Aničić, Boban and Konstantinović, Vitomir and Starch-Jensen, Thomas",
year = "2019",
abstract = "Introduction: The objective of the present study was to assess the demographic variables, causes, and patterns of edentulous atrophic fractures of the mandible managed at several European departments of oral and maxillofacial surgery. The results of this multicenter collaboration over a 10-year period are presented. Methods: The data of all patients with fractures of the atrophic edentulous mandible from the involved maxillofacial surgical units across Europe between January 1, 2008, and December 31, 2017 were recorded: gender; age; voluptuary habits; comorbidities; etiology; fracture sites; synchronous body injuries; atrophy of the mandible according to Luhr classification; eventual type of treatment; timing of the eventual surgery; length of hospital stay. Results: A total of 197 patients (86 male and 111 female patients) with 285 mandibular fractures were included in the study. Mean age of the study populationwas 75 years. Statistically significant associations were found between Luhr classes I - II and condylar fractures on one hand (p  lt .0005), and between Luhr class III and body and parasymphyseal fractures on the other hand (p  lt .05). Finally, 135 patients underwent open reduction and internal fixation, 56 patients did not undergo any intervention, and 6 patients underwent closed reduction. No statistically significant association was observed between treatment, timing of treatment, comorbidities, and concomitant injuries. Conclusions: The management of edentulous atrophic mandibular fractures remains challenging. Treatment decisions should continue to be based on the clinician's previous experience and on the degree of bone resorption in edentulous mandible in relation to fracture subsites.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Journal of Cranio-Maxillofacial Surgery",
title = "The epidemiology of edentulous atrophic mandibular fractures in Europe",
volume = "47",
number = "12",
pages = "1929-1934",
doi = "10.1016/j.jcms.2019.11.021"
}

Brucoli, M., Boffano, P., Romeo, I., Corio, C., Benech, A., Ruslin, M., Forouzanfar, T., Rodriguez-Santamarta, T., de Vicente, J. C., Tarle, M., Dediol, E., Pechalova, P., Pavlov, N., Daskalov, H., Doykova, I., Kelemith, K., Tamme, T., Kopchak, A., Shumynskyi, I., Corre, P., Bertin, H., Bourry, M., Guyonvarc'h, P., Dovšak, T., Vozlić, D., Birk, A., Aničić, B., Konstantinović, V.,& Starch-Jensen, T.. (2019). The epidemiology of edentulous atrophic mandibular fractures in Europe. in Journal of Cranio-Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 47(12), 1929-1934.
https://doi.org/10.1016/j.jcms.2019.11.021

Brucoli M, Boffano P, Romeo I, Corio C, Benech A, Ruslin M, Forouzanfar T, Rodriguez-Santamarta T, de Vicente JC, Tarle M, Dediol E, Pechalova P, Pavlov N, Daskalov H, Doykova I, Kelemith K, Tamme T, Kopchak A, Shumynskyi I, Corre P, Bertin H, Bourry M, Guyonvarc'h P, Dovšak T, Vozlić D, Birk A, Aničić B, Konstantinović V, Starch-Jensen T. The epidemiology of edentulous atrophic mandibular fractures in Europe. in Journal of Cranio-Maxillofacial Surgery. 2019;47(12):1929-1934.
doi:10.1016/j.jcms.2019.11.021 .

Brucoli, Matteo, Boffano, Paolo, Romeo, Irene, Corio, Chiara, Benech, Arnaldo, Ruslin, Muhammad, Forouzanfar, Tymour, Rodriguez-Santamarta, Tania, de Vicente, Juan Carlos, Tarle, Marko, Dediol, Emil, Pechalova, Petia, Pavlov, Nikolai, Daskalov, Hristo, Doykova, Iva, Kelemith, Kadri, Tamme, Tiia, Kopchak, Andrey, Shumynskyi, Ievgen, Corre, Pierre, Bertin, Helios, Bourry, Maeva, Guyonvarc'h, Pierre, Dovšak, Tadej, Vozlić, David, Birk, Anze, Aničić, Boban, Konstantinović, Vitomir, Starch-Jensen, Thomas, "The epidemiology of edentulous atrophic mandibular fractures in Europe" in Journal of Cranio-Maxillofacial Surgery, 47, no. 12 (2019):1929-1934,
https://doi.org/10.1016/j.jcms.2019.11.021 . .

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Ilic-Dimitrijević, Ivana
AU  - Eljabo, Najib
AU  - Radunović, Milena
AU  - Aničić, Boban
AU  - Tanić, Nasta
AU  - Falk, Markus
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2317
AB  - Objective. To investigate the prevalence of p16(INK4) (a), p14(ARF), tumor protein p53 (TP53), and human telomerase reverse transcriptase (hTERT) promoter hypermethylation in mucoepidermoid carcinomas (MECs) and search for a possible association between methylation status and clinicopathological parameters. Study design. DNA extracted from 35 formalin-fixed and paraffin-embedded MEC samples and 10 normal salivary gland (NSG) tissue samples was analyzed for the presence of promoter hypermethylation using methylation-specific polymerase chain reaction testing. Results. The percentages of gene hypermethylation in MECs versus NSGs were the following: p14: 100% versus 20% (P  lt  .001); p16: 60% versus 20% (P = .035); hTERT: 54.3% versus 20% (P = .078); and TP53: 31.4% versus 30% (P = .981). Multiple sites were found to be methylated in 86% of MECs compared with 10% in NSGs (P  lt  .001). TP53 and hTERT were more often methylated in lower clinical stages (P = .033 and P = .005, respectively). Conclusions. Hypermethylation of p14 appears to be an important event in the development of mucoepidermoid carcinoma. High frequency of gene hypermethylation and high incidence of methylation at multiple sites point to the importance of epigenetic phenomena in the pathogenesis of MECs, although with modest impact on clinical parameters.
PB  - Elsevier Science Inc, New York
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
T1  - P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population
VL  - 125
IS  - 1
SP  - 52
EP  - 58
DO  - 10.1016/j.oooo.2017.09.013
ER  - 

@article{
author = "Nikolić, Nadja and Čarkić, Jelena and Ilic-Dimitrijević, Ivana and Eljabo, Najib and Radunović, Milena and Aničić, Boban and Tanić, Nasta and Falk, Markus and Milašin, Jelena",
year = "2018",
abstract = "Objective. To investigate the prevalence of p16(INK4) (a), p14(ARF), tumor protein p53 (TP53), and human telomerase reverse transcriptase (hTERT) promoter hypermethylation in mucoepidermoid carcinomas (MECs) and search for a possible association between methylation status and clinicopathological parameters. Study design. DNA extracted from 35 formalin-fixed and paraffin-embedded MEC samples and 10 normal salivary gland (NSG) tissue samples was analyzed for the presence of promoter hypermethylation using methylation-specific polymerase chain reaction testing. Results. The percentages of gene hypermethylation in MECs versus NSGs were the following: p14: 100% versus 20% (P  lt  .001); p16: 60% versus 20% (P = .035); hTERT: 54.3% versus 20% (P = .078); and TP53: 31.4% versus 30% (P = .981). Multiple sites were found to be methylated in 86% of MECs compared with 10% in NSGs (P  lt  .001). TP53 and hTERT were more often methylated in lower clinical stages (P = .033 and P = .005, respectively). Conclusions. Hypermethylation of p14 appears to be an important event in the development of mucoepidermoid carcinoma. High frequency of gene hypermethylation and high incidence of methylation at multiple sites point to the importance of epigenetic phenomena in the pathogenesis of MECs, although with modest impact on clinical parameters.",
publisher = "Elsevier Science Inc, New York",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology",
title = "P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population",
volume = "125",
number = "1",
pages = "52-58",
doi = "10.1016/j.oooo.2017.09.013"
}

Nikolić, N., Čarkić, J., Ilic-Dimitrijević, I., Eljabo, N., Radunović, M., Aničić, B., Tanić, N., Falk, M.,& Milašin, J.. (2018). P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Elsevier Science Inc, New York., 125(1), 52-58.
https://doi.org/10.1016/j.oooo.2017.09.013

Nikolić N, Čarkić J, Ilic-Dimitrijević I, Eljabo N, Radunović M, Aničić B, Tanić N, Falk M, Milašin J. P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2018;125(1):52-58.
doi:10.1016/j.oooo.2017.09.013 .

Nikolić, Nadja, Čarkić, Jelena, Ilic-Dimitrijević, Ivana, Eljabo, Najib, Radunović, Milena, Aničić, Boban, Tanić, Nasta, Falk, Markus, Milašin, Jelena, "P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population" in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 125, no. 1 (2018):52-58,
https://doi.org/10.1016/j.oooo.2017.09.013 . .

TY  - JOUR
AU  - Dožić, Branko
AU  - Glumac, Sofija
AU  - Boricić, Novica
AU  - Dozić, Marko
AU  - Aničić, Boban
AU  - Boričić, Ivan
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2141
AB  - Purpose: Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. It is characterized by a high rate of recurrence, perineural invasion and development of distant metastases many years after removal of the primary tumor. Disorders of the induction of apoptosis and its cascade reactions where caspases are involved may be significant in the pathogenesis of this tumor. Methods: The immunohistochemical expression of caspase 9 and caspase 3 was analyzed by tissue microarray (TMA) in 50 cases of ACC in relation with different clinicopathological parameters (gender, age, localization, histological type and overall survival). Results: Caspase 9 was expressed in the cytoplasm and nuclei of ACC tumor cells with varying degrees of staining intensity (1+, 6%; 2+, 54%, 3+, 40%). Comparison of caspase 9 expression in tumor cells with clinicopathological parameters (gender, age, localization, histological type and overall survival) showed no statistically significant difference except that the expression was more pronounced in females. Caspase 3 was expressed in the cytoplasm of tumor cells with varying degrees of staining intensity (1+, 22%; 2+, 36%; 3+, 42%). No correlation between the expression of caspase 3 and clinicopathological parameters was noticed. Conclusions: The expression of caspases 9 and 3 in ACC of the salivary glands can contribute in the better characterization of molecules involved in apoptosis of tumor cells.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters
VL  - 21
IS  - 1
SP  - 152
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_smile_2141
ER  - 

@article{
author = "Dožić, Branko and Glumac, Sofija and Boricić, Novica and Dozić, Marko and Aničić, Boban and Boričić, Ivan",
year = "2016",
abstract = "Purpose: Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. It is characterized by a high rate of recurrence, perineural invasion and development of distant metastases many years after removal of the primary tumor. Disorders of the induction of apoptosis and its cascade reactions where caspases are involved may be significant in the pathogenesis of this tumor. Methods: The immunohistochemical expression of caspase 9 and caspase 3 was analyzed by tissue microarray (TMA) in 50 cases of ACC in relation with different clinicopathological parameters (gender, age, localization, histological type and overall survival). Results: Caspase 9 was expressed in the cytoplasm and nuclei of ACC tumor cells with varying degrees of staining intensity (1+, 6%; 2+, 54%, 3+, 40%). Comparison of caspase 9 expression in tumor cells with clinicopathological parameters (gender, age, localization, histological type and overall survival) showed no statistically significant difference except that the expression was more pronounced in females. Caspase 3 was expressed in the cytoplasm of tumor cells with varying degrees of staining intensity (1+, 22%; 2+, 36%; 3+, 42%). No correlation between the expression of caspase 3 and clinicopathological parameters was noticed. Conclusions: The expression of caspases 9 and 3 in ACC of the salivary glands can contribute in the better characterization of molecules involved in apoptosis of tumor cells.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters",
volume = "21",
number = "1",
pages = "152-160",
url = "https://hdl.handle.net/21.15107/rcub_smile_2141"
}

Dožić, B., Glumac, S., Boricić, N., Dozić, M., Aničić, B.,& Boričić, I.. (2016). Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(1), 152-160.
https://hdl.handle.net/21.15107/rcub_smile_2141

Dožić B, Glumac S, Boricić N, Dozić M, Aničić B, Boričić I. Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters. in Journal of BUON. 2016;21(1):152-160.
https://hdl.handle.net/21.15107/rcub_smile_2141 .

Dožić, Branko, Glumac, Sofija, Boricić, Novica, Dozić, Marko, Aničić, Boban, Boričić, Ivan, "Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters" in Journal of BUON, 21, no. 1 (2016):152-160,
https://hdl.handle.net/21.15107/rcub_smile_2141 .

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Aničić, Boban
AU  - Čarkić, Jelena
AU  - Simonović, Jelena
AU  - Toljić, Boško
AU  - Tanić, Nasta
AU  - Tepavčević, Zvezdana
AU  - Vukadinović, Miroslav
AU  - Konstantinović, Vitomir
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2019
AB  - Objectives: to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands. Materials and Methods: Genomic DNA from paraffin-embedded samples of 50 pleomorphic adenomas and 10 carcinomas ex pleomorphic adenoma was subjected to methylation specific polymerase chain reaction for hypermethylation analyses and real time polymerase chain reaction for the relative telomere length calculations. Results: Promoter hypermethylation of the two genes was a very frequent event in both neoplasms between 60% and 90% of samples were hypermethylated - but without significant difference between the groups. The mean relative telomere length in the pleomorphic adenoma group was significantly increased in comparison to the control group (P = 0.00), and significantly decreased in comparison to the carcinoma group (P = 0.05). Telomeres were also longer in myxoid and cellular histological subtypes of adenomas than in the classic type (P = 0.044 and P = 0.018, respectively). Longer telomeres were more frequent in tumors with hypermethylated p14(ARF) alleles (P = 0.013). Conclusion: Promoter hypermethylations seems to be an important mechanism of p16(INK4a) and Pl4(ARF) inactivation in parotid gland tumors. Telomeric lengthening appears to be involved in the pathogenesis of both benign and malignant tumors of the parotid glands.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Archives of Oral Biology
T1  - High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors
VL  - 60
IS  - 11
SP  - 1662
EP  - 1666
DO  - 10.1016/j.archoralbio.2015.08.011
ER  - 

@article{
author = "Nikolić, Nadja and Aničić, Boban and Čarkić, Jelena and Simonović, Jelena and Toljić, Boško and Tanić, Nasta and Tepavčević, Zvezdana and Vukadinović, Miroslav and Konstantinović, Vitomir and Milašin, Jelena",
year = "2015",
abstract = "Objectives: to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands. Materials and Methods: Genomic DNA from paraffin-embedded samples of 50 pleomorphic adenomas and 10 carcinomas ex pleomorphic adenoma was subjected to methylation specific polymerase chain reaction for hypermethylation analyses and real time polymerase chain reaction for the relative telomere length calculations. Results: Promoter hypermethylation of the two genes was a very frequent event in both neoplasms between 60% and 90% of samples were hypermethylated - but without significant difference between the groups. The mean relative telomere length in the pleomorphic adenoma group was significantly increased in comparison to the control group (P = 0.00), and significantly decreased in comparison to the carcinoma group (P = 0.05). Telomeres were also longer in myxoid and cellular histological subtypes of adenomas than in the classic type (P = 0.044 and P = 0.018, respectively). Longer telomeres were more frequent in tumors with hypermethylated p14(ARF) alleles (P = 0.013). Conclusion: Promoter hypermethylations seems to be an important mechanism of p16(INK4a) and Pl4(ARF) inactivation in parotid gland tumors. Telomeric lengthening appears to be involved in the pathogenesis of both benign and malignant tumors of the parotid glands.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Archives of Oral Biology",
title = "High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors",
volume = "60",
number = "11",
pages = "1662-1666",
doi = "10.1016/j.archoralbio.2015.08.011"
}

Nikolić, N., Aničić, B., Čarkić, J., Simonović, J., Toljić, B., Tanić, N., Tepavčević, Z., Vukadinović, M., Konstantinović, V.,& Milašin, J.. (2015). High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors. in Archives of Oral Biology
Pergamon-Elsevier Science Ltd, Oxford., 60(11), 1662-1666.
https://doi.org/10.1016/j.archoralbio.2015.08.011

Nikolić N, Aničić B, Čarkić J, Simonović J, Toljić B, Tanić N, Tepavčević Z, Vukadinović M, Konstantinović V, Milašin J. High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors. in Archives of Oral Biology. 2015;60(11):1662-1666.
doi:10.1016/j.archoralbio.2015.08.011 .

Nikolić, Nadja, Aničić, Boban, Čarkić, Jelena, Simonović, Jelena, Toljić, Boško, Tanić, Nasta, Tepavčević, Zvezdana, Vukadinović, Miroslav, Konstantinović, Vitomir, Milašin, Jelena, "High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors" in Archives of Oral Biology, 60, no. 11 (2015):1662-1666,
https://doi.org/10.1016/j.archoralbio.2015.08.011 . .

TY  - THES
AU  - Aničić, Boban
PY  - 2014
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=2851
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:11057/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024225166
UR  - http://nardus.mpn.gov.rs/123456789/5297
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/971
AB  - Background: Genetic studies of salivary gland neoplasms including pleomorphic adenomas (PA) were mainly focused on chromosomal changes and several specific patterns of chromosome translocations have been described. Molecular changes involved in tumour pathogenesis are less well characterized, and data regarding genetic polymorphisms as risk factors for PA development are almost inexistent. Aim: The aim of this thesis was to investigate the putative role of several polymorphisms in genes involved in apoptosis (survivin), cell cycle control and apoptosis (TP53), and extracellular matrix degradation and remodeling (matrix metalloproteinases - MMP-9) as potential susceptibility factors and prognostic factors in Serbian patients with PA. Materials and Methods: DNA was extracted from 74 formalin fixed, paraffin embedded samples of PA that were surgically removed at the Clinic of Maxillofacial Surgery, School of Dental Medicine, University of Belgrade. Control specimens of DNA were extracted from buccal swabs of healthy donors, sex and age matched with the patients group. Polymorphisms analysis of single nucleotide polymorphisms (SNPs) in the promoter region of the survivin gene, at positions -241 (a C/T substitution) and -31 (a G/C substitution), in the promoter region (-1562 C/T) of the MMP-9 gene, and Pro47Ser in the TP53 gene, was performed by PCR-RFLP followed by electrophoresis. The insertion polymorphism in the TP53 gene, PIN3 Ins 16bp was analyzed by PCR and gel electrophoresis. The association of genotypes and phenotypes with risk of PA development and clinical parameters of the tumor was determined using logistic regression analysis...
AB  - Uvod : Genetičke studije neoplazmi pljuvačnih žlezda, uključujući i pleomorfni adenom (PA) su uglavnom bile fokusirane na hromozomske aberacije, i nekoliko specifičnih obrazaca hromozomskih translokacija je do sada opisano kao ključni događaji u nastanku PA. Molekularne promene uključene u patogenezu ovih tumora znatno su manje izučavane i okarakterisane, a podaci o genetičkim polimorfizmima kao faktorima rizika za razvoj PA ili kao prognostičkim faktorima, gotovo da su nepostojeći . Cilj: Cilj ovog rada bio je da se ispita potencijalna ulogu nekoliko polimorfizama u genima koji su uključeni u apoptozu i kontrolu ćelijskog ciklusa (survivin, TP53) i degradaciju i remodeliranje ekstracelularnog matriksa (matriksna metaloproteinaza 9 - MMP-9), kao potencijalnih faktora susceptibilnosti za nastanak pleomorfnom adenoma i kao prognostičkih markera u populaciji Srbije. Materijal i metode: DNK je izolovana iz 74 parafinska uzorka pleomorfnih adenoma pacijenata operisanih na Klinici za Maksilofacijalnu hirurgiju Stomatološkog fakulteta, Univerziteta u Beogradu. Kontrolna DNK je dobijena iz limfocita periferne krvi zdravih dobrovoljnih davalaca krvi, koji su odgovarali pacijentima u pogledu polne i starosne strukture. Analiza polimorfizama pojedinačnih nukleotida („single nucleotide polymorphism“-SNP) u regionu promotora gena za survivin, na položajima -241 (C/T supstitucija) i -31 (G/C supstitucija), zatim u promotorskom regionu MMP-9 gena (-1562 C/T supstitucija), i konačno SNP Pro47Ser u TP53 genu, urađena je metodom lančane reakcije polimeraze (Polymerase Chain Reaction-PCR) i restrikcionom analizom (polimorfizmi dužine restrikcionih fragmenata odnsosno „Restriction Fragment Length Polymorphism-RFLP) zatim elektroforezom. Insercioni polimorfizam u TP53 gena, PIN3 Ins 16bp je analiziran pomoću PCR i gel elektroforeze. Asocijacija između genotipova i alela i rizika od razvoja PA, kao i kliničkih parametara tumora određena je korišćenjem logističke regresione analize...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Genetic variability and risk of development of salivary gland pleomorphic adenoma: analysis of survivin, TP53 and matrix metalloproteinase 9 genes
T1  - Varijabilnost nasledne osnove i rizik od nastanka pleomorfnog adenoma pljuvačnih žlezda - analiza gena za survivin, TP53 i matriksnu metaloproteinazu 9
UR  - https://hdl.handle.net/21.15107/rcub_nardus_5297
ER  - 

@phdthesis{
author = "Aničić, Boban",
year = "2014",
abstract = "Background: Genetic studies of salivary gland neoplasms including pleomorphic adenomas (PA) were mainly focused on chromosomal changes and several specific patterns of chromosome translocations have been described. Molecular changes involved in tumour pathogenesis are less well characterized, and data regarding genetic polymorphisms as risk factors for PA development are almost inexistent. Aim: The aim of this thesis was to investigate the putative role of several polymorphisms in genes involved in apoptosis (survivin), cell cycle control and apoptosis (TP53), and extracellular matrix degradation and remodeling (matrix metalloproteinases - MMP-9) as potential susceptibility factors and prognostic factors in Serbian patients with PA. Materials and Methods: DNA was extracted from 74 formalin fixed, paraffin embedded samples of PA that were surgically removed at the Clinic of Maxillofacial Surgery, School of Dental Medicine, University of Belgrade. Control specimens of DNA were extracted from buccal swabs of healthy donors, sex and age matched with the patients group. Polymorphisms analysis of single nucleotide polymorphisms (SNPs) in the promoter region of the survivin gene, at positions -241 (a C/T substitution) and -31 (a G/C substitution), in the promoter region (-1562 C/T) of the MMP-9 gene, and Pro47Ser in the TP53 gene, was performed by PCR-RFLP followed by electrophoresis. The insertion polymorphism in the TP53 gene, PIN3 Ins 16bp was analyzed by PCR and gel electrophoresis. The association of genotypes and phenotypes with risk of PA development and clinical parameters of the tumor was determined using logistic regression analysis..., Uvod : Genetičke studije neoplazmi pljuvačnih žlezda, uključujući i pleomorfni adenom (PA) su uglavnom bile fokusirane na hromozomske aberacije, i nekoliko specifičnih obrazaca hromozomskih translokacija je do sada opisano kao ključni događaji u nastanku PA. Molekularne promene uključene u patogenezu ovih tumora znatno su manje izučavane i okarakterisane, a podaci o genetičkim polimorfizmima kao faktorima rizika za razvoj PA ili kao prognostičkim faktorima, gotovo da su nepostojeći . Cilj: Cilj ovog rada bio je da se ispita potencijalna ulogu nekoliko polimorfizama u genima koji su uključeni u apoptozu i kontrolu ćelijskog ciklusa (survivin, TP53) i degradaciju i remodeliranje ekstracelularnog matriksa (matriksna metaloproteinaza 9 - MMP-9), kao potencijalnih faktora susceptibilnosti za nastanak pleomorfnom adenoma i kao prognostičkih markera u populaciji Srbije. Materijal i metode: DNK je izolovana iz 74 parafinska uzorka pleomorfnih adenoma pacijenata operisanih na Klinici za Maksilofacijalnu hirurgiju Stomatološkog fakulteta, Univerziteta u Beogradu. Kontrolna DNK je dobijena iz limfocita periferne krvi zdravih dobrovoljnih davalaca krvi, koji su odgovarali pacijentima u pogledu polne i starosne strukture. Analiza polimorfizama pojedinačnih nukleotida („single nucleotide polymorphism“-SNP) u regionu promotora gena za survivin, na položajima -241 (C/T supstitucija) i -31 (G/C supstitucija), zatim u promotorskom regionu MMP-9 gena (-1562 C/T supstitucija), i konačno SNP Pro47Ser u TP53 genu, urađena je metodom lančane reakcije polimeraze (Polymerase Chain Reaction-PCR) i restrikcionom analizom (polimorfizmi dužine restrikcionih fragmenata odnsosno „Restriction Fragment Length Polymorphism-RFLP) zatim elektroforezom. Insercioni polimorfizam u TP53 gena, PIN3 Ins 16bp je analiziran pomoću PCR i gel elektroforeze. Asocijacija između genotipova i alela i rizika od razvoja PA, kao i kliničkih parametara tumora određena je korišćenjem logističke regresione analize...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Genetic variability and risk of development of salivary gland pleomorphic adenoma: analysis of survivin, TP53 and matrix metalloproteinase 9 genes, Varijabilnost nasledne osnove i rizik od nastanka pleomorfnog adenoma pljuvačnih žlezda - analiza gena za survivin, TP53 i matriksnu metaloproteinazu 9",
url = "https://hdl.handle.net/21.15107/rcub_nardus_5297"
}

Aničić, B.. (2014). Genetic variability and risk of development of salivary gland pleomorphic adenoma: analysis of survivin, TP53 and matrix metalloproteinase 9 genes. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_5297

Aničić B. Genetic variability and risk of development of salivary gland pleomorphic adenoma: analysis of survivin, TP53 and matrix metalloproteinase 9 genes. 2014;.
https://hdl.handle.net/21.15107/rcub_nardus_5297 .

Aničić, Boban, "Genetic variability and risk of development of salivary gland pleomorphic adenoma: analysis of survivin, TP53 and matrix metalloproteinase 9 genes" (2014),
https://hdl.handle.net/21.15107/rcub_nardus_5297 .

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Aničić, Boban
AU  - Tepavčević, Zvezdana
AU  - Jezdić, Zoran
AU  - Čarkić, Jelena
AU  - Toljić, Boško
AU  - Dedović-Tanić, Nasta
AU  - Konstantinović, Vitomir
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1779
AB  - Background: Genetic studies of salivary gland neoplasms were mainly focused on chromosomal changes, and some specific patterns of chromosome translocations have been described. However, molecular alterations, in particular the role of HER-2/H-ras/c-myc signalling cascade in pleomorphic adenoma pathogenesis (PA), are less well characterized. In addition, data on single nucleotide polymorphisms (SNPs) as potential susceptibility factors for PA development are also quite scarce. Methods: Mutational analyses were performed by means of real-time PCR (HER-2 and c-myc amplification analysis), PCR-SSCP and sequencing (H-ras point mutation detection). Polymorphisms analysis was performed by PCR-RFLP (survivin and MMP-9 genes). Results: Amplification of HER-2 and c-myc has been found in 13% and 9% of PA cases respectively. Point mutations in H-ras codons 12/13 have been detected in 17% of PAs. No correlation could be established between these alterations and clinical characteristics of PAs, whereas they might play a role in a subset of malignant salivary gland tumours. As for survivin -31 G/C polymorphism, C allele carriers had a 4-fold decrease of the risk of developing PA (p=0.05). Carriers of the variant allele T of the -1562C/T SNP in MMP-9 gene had a 4-fold increase of the risk of developing PA (p lt 0.001). Conclusions: A longer follow-up of PA patients harbouring mutations could uncover a prognostic role of HER-2 and c-myc amplification as predictors of adenoma transformation into carcinoma. Both survivin and MMP-9 promoter polymorphisms represent susceptibility factors for the development of PAs in the Serbian population.
AB  - Uvod: U ispitivanjima mehanizama nastanka tumora pljuvačnih žlezda uglavnom dominiraju citogenetičke studije, pa su tako detektovane i opisane različite hromozomske translokacije sa specifičnim obrascem javljanja. Međutim, molekularne promene u ovim tumorima i dalje su relativno slabo poznate, a pogotovo je malo podataka o potencijalnom značaju signalnog puta HER-2/H-ras/c-myc u razvoju i progresiji pleomorfnih adenoma (PA). Takođe, retki su i podaci 0 polimorfizmima pojedinačnog nukleotida (SNP) kao faktora predispozicije za nastanak PA. Metode: Analize somatskih mutacija urađene su metodama real-time PCR (analiza amplifikacije HER-2 i c-myc), PCR-SSCP i sekvenciranja (detekcija tačkastih mutacija u H-ras). Ana I iza polimorfizama pojedinačnih nukleotida (SNP) vršena je prime- nom metode PCR-RFLP (u genima za survivin i MMP-9). Rezultati: Amplifikacija gena HER-2 detektovana je u 13%, c-myc u 9% a tačkaste mutacije u kodonima 12/13 H-ras gena u 17% uzoraka. Nije ustanovljena veza između ovih promena i kliničkih odlika adenoma. Na malom uzorku karcinoma, pokazano je da je amplifikacija HER-2 povezana sa recidivima tumora. Nosioci C alela u -31G/C SNP gena za survivin imaju četiri puta manji rizik od nastanka PA (p=0,05), dok nosioci varijantnog alela T kod -1562 C/T SNP u MMP-9 genu imaju četiri puta veći rizik da obole od PA u odnosu na kontrolu (p lt 0,001). Zaključak: Dužim praćenjem pacijenata sa PA mogla bi da se ustanovi prognostička uloga HER-2 i c-myc amplifikacija kao indikatora za transformaciju adenoma u karcinom. Polimorfizmi u promotorima gena za survivin i MMP-9 predstavljaju modulatore rizika za razvoj pleomorfnih adenoma u srpskoj populaciji.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands
T1  - Somatske mutacije i analiza polimorfizama u pleomorfnim adenomima pljuvačnih žlezda
VL  - 32
IS  - 4
SP  - 354
EP  - 360
DO  - 10.2478/jomb-2013-0048
ER  - 

@article{
author = "Nikolić, Nadja and Aničić, Boban and Tepavčević, Zvezdana and Jezdić, Zoran and Čarkić, Jelena and Toljić, Boško and Dedović-Tanić, Nasta and Konstantinović, Vitomir and Vukadinović, Miroslav and Milašin, Jelena",
year = "2013",
abstract = "Background: Genetic studies of salivary gland neoplasms were mainly focused on chromosomal changes, and some specific patterns of chromosome translocations have been described. However, molecular alterations, in particular the role of HER-2/H-ras/c-myc signalling cascade in pleomorphic adenoma pathogenesis (PA), are less well characterized. In addition, data on single nucleotide polymorphisms (SNPs) as potential susceptibility factors for PA development are also quite scarce. Methods: Mutational analyses were performed by means of real-time PCR (HER-2 and c-myc amplification analysis), PCR-SSCP and sequencing (H-ras point mutation detection). Polymorphisms analysis was performed by PCR-RFLP (survivin and MMP-9 genes). Results: Amplification of HER-2 and c-myc has been found in 13% and 9% of PA cases respectively. Point mutations in H-ras codons 12/13 have been detected in 17% of PAs. No correlation could be established between these alterations and clinical characteristics of PAs, whereas they might play a role in a subset of malignant salivary gland tumours. As for survivin -31 G/C polymorphism, C allele carriers had a 4-fold decrease of the risk of developing PA (p=0.05). Carriers of the variant allele T of the -1562C/T SNP in MMP-9 gene had a 4-fold increase of the risk of developing PA (p lt 0.001). Conclusions: A longer follow-up of PA patients harbouring mutations could uncover a prognostic role of HER-2 and c-myc amplification as predictors of adenoma transformation into carcinoma. Both survivin and MMP-9 promoter polymorphisms represent susceptibility factors for the development of PAs in the Serbian population., Uvod: U ispitivanjima mehanizama nastanka tumora pljuvačnih žlezda uglavnom dominiraju citogenetičke studije, pa su tako detektovane i opisane različite hromozomske translokacije sa specifičnim obrascem javljanja. Međutim, molekularne promene u ovim tumorima i dalje su relativno slabo poznate, a pogotovo je malo podataka o potencijalnom značaju signalnog puta HER-2/H-ras/c-myc u razvoju i progresiji pleomorfnih adenoma (PA). Takođe, retki su i podaci 0 polimorfizmima pojedinačnog nukleotida (SNP) kao faktora predispozicije za nastanak PA. Metode: Analize somatskih mutacija urađene su metodama real-time PCR (analiza amplifikacije HER-2 i c-myc), PCR-SSCP i sekvenciranja (detekcija tačkastih mutacija u H-ras). Ana I iza polimorfizama pojedinačnih nukleotida (SNP) vršena je prime- nom metode PCR-RFLP (u genima za survivin i MMP-9). Rezultati: Amplifikacija gena HER-2 detektovana je u 13%, c-myc u 9% a tačkaste mutacije u kodonima 12/13 H-ras gena u 17% uzoraka. Nije ustanovljena veza između ovih promena i kliničkih odlika adenoma. Na malom uzorku karcinoma, pokazano je da je amplifikacija HER-2 povezana sa recidivima tumora. Nosioci C alela u -31G/C SNP gena za survivin imaju četiri puta manji rizik od nastanka PA (p=0,05), dok nosioci varijantnog alela T kod -1562 C/T SNP u MMP-9 genu imaju četiri puta veći rizik da obole od PA u odnosu na kontrolu (p lt 0,001). Zaključak: Dužim praćenjem pacijenata sa PA mogla bi da se ustanovi prognostička uloga HER-2 i c-myc amplifikacija kao indikatora za transformaciju adenoma u karcinom. Polimorfizmi u promotorima gena za survivin i MMP-9 predstavljaju modulatore rizika za razvoj pleomorfnih adenoma u srpskoj populaciji.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands, Somatske mutacije i analiza polimorfizama u pleomorfnim adenomima pljuvačnih žlezda",
volume = "32",
number = "4",
pages = "354-360",
doi = "10.2478/jomb-2013-0048"
}

Nikolić, N., Aničić, B., Tepavčević, Z., Jezdić, Z., Čarkić, J., Toljić, B., Dedović-Tanić, N., Konstantinović, V., Vukadinović, M.,& Milašin, J.. (2013). Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 32(4), 354-360.
https://doi.org/10.2478/jomb-2013-0048

Nikolić N, Aničić B, Tepavčević Z, Jezdić Z, Čarkić J, Toljić B, Dedović-Tanić N, Konstantinović V, Vukadinović M, Milašin J. Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands. in Journal of Medical Biochemistry. 2013;32(4):354-360.
doi:10.2478/jomb-2013-0048 .

Nikolić, Nadja, Aničić, Boban, Tepavčević, Zvezdana, Jezdić, Zoran, Čarkić, Jelena, Toljić, Boško, Dedović-Tanić, Nasta, Konstantinović, Vitomir, Vukadinović, Miroslav, Milašin, Jelena, "Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands" in Journal of Medical Biochemistry, 32, no. 4 (2013):354-360,
https://doi.org/10.2478/jomb-2013-0048 . .

TY  - JOUR
AU  - Konstantinović, Vitomir
AU  - Puzović, Dragana
AU  - Aničić, Boban
AU  - Jelovac, Drago
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1557
AB  - The aim of this article was the epidemiological, clinical, and forensic evaluation of the chainsaw, circular saw, and grinding saw maxillofacial injuries. A retrospective analysis of the medical records at the Clinic of Maxillofacial Surgery, School of Dentistry, University of Belgrade, was performed. A total of 133 patients were treated during a period of 19 years (1989-2008). Grinding saw injuries were more frequent (62%) in comparison to chainsaw and circular saw injuries that were present in 23% and 15% of patients, respectively. All injured individuals were men, and most of them were aged 31 to 40 years. Accident by self injuring was the only mechanism of all the analyzed injuries. There were no suicide or homicide attempts. Isolated injuries of the facial soft tissues, which were mainly lacerations, were present in most patients. Less frequently, soft tissues injuries were compounded with bone fractures of the face and teeth injuries. Surgical debridement, revision, and suturing were performed in all patients where only soft tissues were injured. Patients with compound injuries of the soft tissues, facial bones, and teeth were treated according to the common surgical protocol for the type of the injuries. Most often, these injuries were accidental without fatalities. The number of these injuries increased in the recent years owing to the "do-it-yourselfers" for home hobbies. To avoid these types of injuries, users should be carefully instructed, and attention should be paid to the use of accurately guarded saws and appropriate safety equipment.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Craniofacial Surgery
T1  - Epidemiological, Clinical, and Forensic Aspects of Chainsaw, Circular Saw, and Grinding Saw Injuries in the Maxillofacial Region
VL  - 21
IS  - 4
SP  - 1029
EP  - 1032
DO  - 10.1097/SCS.0b013e3181e432bd
ER  - 

@article{
author = "Konstantinović, Vitomir and Puzović, Dragana and Aničić, Boban and Jelovac, Drago",
year = "2010",
abstract = "The aim of this article was the epidemiological, clinical, and forensic evaluation of the chainsaw, circular saw, and grinding saw maxillofacial injuries. A retrospective analysis of the medical records at the Clinic of Maxillofacial Surgery, School of Dentistry, University of Belgrade, was performed. A total of 133 patients were treated during a period of 19 years (1989-2008). Grinding saw injuries were more frequent (62%) in comparison to chainsaw and circular saw injuries that were present in 23% and 15% of patients, respectively. All injured individuals were men, and most of them were aged 31 to 40 years. Accident by self injuring was the only mechanism of all the analyzed injuries. There were no suicide or homicide attempts. Isolated injuries of the facial soft tissues, which were mainly lacerations, were present in most patients. Less frequently, soft tissues injuries were compounded with bone fractures of the face and teeth injuries. Surgical debridement, revision, and suturing were performed in all patients where only soft tissues were injured. Patients with compound injuries of the soft tissues, facial bones, and teeth were treated according to the common surgical protocol for the type of the injuries. Most often, these injuries were accidental without fatalities. The number of these injuries increased in the recent years owing to the "do-it-yourselfers" for home hobbies. To avoid these types of injuries, users should be carefully instructed, and attention should be paid to the use of accurately guarded saws and appropriate safety equipment.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Craniofacial Surgery",
title = "Epidemiological, Clinical, and Forensic Aspects of Chainsaw, Circular Saw, and Grinding Saw Injuries in the Maxillofacial Region",
volume = "21",
number = "4",
pages = "1029-1032",
doi = "10.1097/SCS.0b013e3181e432bd"
}

Konstantinović, V., Puzović, D., Aničić, B.,& Jelovac, D.. (2010). Epidemiological, Clinical, and Forensic Aspects of Chainsaw, Circular Saw, and Grinding Saw Injuries in the Maxillofacial Region. in Journal of Craniofacial Surgery
Lippincott Williams & Wilkins, Philadelphia., 21(4), 1029-1032.
https://doi.org/10.1097/SCS.0b013e3181e432bd

Konstantinović V, Puzović D, Aničić B, Jelovac D. Epidemiological, Clinical, and Forensic Aspects of Chainsaw, Circular Saw, and Grinding Saw Injuries in the Maxillofacial Region. in Journal of Craniofacial Surgery. 2010;21(4):1029-1032.
doi:10.1097/SCS.0b013e3181e432bd .

Konstantinović, Vitomir, Puzović, Dragana, Aničić, Boban, Jelovac, Drago, "Epidemiological, Clinical, and Forensic Aspects of Chainsaw, Circular Saw, and Grinding Saw Injuries in the Maxillofacial Region" in Journal of Craniofacial Surgery, 21, no. 4 (2010):1029-1032,
https://doi.org/10.1097/SCS.0b013e3181e432bd . .

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Aničić, Boban
AU  - Sinobad, Vladimir
AU  - Miković, Nikola
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1273
AB  - Background/Aim. To establish the influence of surgical corrections of mandibular prognathism upon the position of the lower and upper anterior teeth (incisors). Methods. The changes in position of the lower and upper anterior teeth (incisors) after the surgical correction of mandibular prognathism were analyzed by means of x-ray craniometry in 183 patients (female: n = 110, male: n = 73) in which the correction had been made in accordance with the principles of sagital osteotomy of the mandibular ramus. There were 4 angular and 2 linear parameters determined in the pre- and postoperative tele-xray-pictures. The changes of these parameters were tested by means of the parametric statistic tests. Results. The performed surgical procedures did not cause statistically significant changes in the angular parameters. The changes of both linear parameters were thought highly statistically significant. Conclusion. Under the influence of the performed surgical procedures no changes were found in the position of anterior teeth (incisors) in relation to SN and the mandibular plane. They were actually moved along with the medium fragment of the lower jaw and that fragment was moved linearly backwards along the occlusal plane with a practically insignificant rotation in the cranial direction.
AB  - Uvod/Cilj. Utvrditi uticaj hirurške korekcije mandibularnog prognatizma na položaj donjih i gornjih sekutića. Metode. Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma analizirane su rendgenkraniometrijski kod 183 osobe (ž = 110; m = 73) kod kojih je korekcija izvršena po principima sagitalnih osteotomija ramusa mandibule. Na preoperativnim i postoperativnim telerendgenogramima određivana su četiri angularna i dva linearna parametra. Promene tih parametara testirane su pomoću parametrijskih statističkih testova. Rezultati. Sprovedene hirurške procedure nisu izazvale statistički značajne promene angularnih parametara. Promene oba linearna parametra bile su visoko statistički značajne. Zaključak. Pod uticajem sprovedenih hirurških korektivnih procedura ne dolazi do promene položaja sekutića u odnosu na SN i mandibularnu ravan, već se oni pomeraju zajedno sa središnjim fragmentom donje vilice. Taj fragment se kreće translatorno unazad duž okluzalne ravni, sa praktično zanemarljivom rotacijom u kranijalnom pravcu.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism
T1  - Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma
VL  - 63
IS  - 5
SP  - 457
EP  - 460
DO  - 10.2298/VSP0605457V
ER  - 

@article{
author = "Vukadinović, Miroslav and Jezdić, Zoran and Aničić, Boban and Sinobad, Vladimir and Miković, Nikola",
year = "2006",
abstract = "Background/Aim. To establish the influence of surgical corrections of mandibular prognathism upon the position of the lower and upper anterior teeth (incisors). Methods. The changes in position of the lower and upper anterior teeth (incisors) after the surgical correction of mandibular prognathism were analyzed by means of x-ray craniometry in 183 patients (female: n = 110, male: n = 73) in which the correction had been made in accordance with the principles of sagital osteotomy of the mandibular ramus. There were 4 angular and 2 linear parameters determined in the pre- and postoperative tele-xray-pictures. The changes of these parameters were tested by means of the parametric statistic tests. Results. The performed surgical procedures did not cause statistically significant changes in the angular parameters. The changes of both linear parameters were thought highly statistically significant. Conclusion. Under the influence of the performed surgical procedures no changes were found in the position of anterior teeth (incisors) in relation to SN and the mandibular plane. They were actually moved along with the medium fragment of the lower jaw and that fragment was moved linearly backwards along the occlusal plane with a practically insignificant rotation in the cranial direction., Uvod/Cilj. Utvrditi uticaj hirurške korekcije mandibularnog prognatizma na položaj donjih i gornjih sekutića. Metode. Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma analizirane su rendgenkraniometrijski kod 183 osobe (ž = 110; m = 73) kod kojih je korekcija izvršena po principima sagitalnih osteotomija ramusa mandibule. Na preoperativnim i postoperativnim telerendgenogramima određivana su četiri angularna i dva linearna parametra. Promene tih parametara testirane su pomoću parametrijskih statističkih testova. Rezultati. Sprovedene hirurške procedure nisu izazvale statistički značajne promene angularnih parametara. Promene oba linearna parametra bile su visoko statistički značajne. Zaključak. Pod uticajem sprovedenih hirurških korektivnih procedura ne dolazi do promene položaja sekutića u odnosu na SN i mandibularnu ravan, već se oni pomeraju zajedno sa središnjim fragmentom donje vilice. Taj fragment se kreće translatorno unazad duž okluzalne ravni, sa praktično zanemarljivom rotacijom u kranijalnom pravcu.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism, Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma",
volume = "63",
number = "5",
pages = "457-460",
doi = "10.2298/VSP0605457V"
}

Vukadinović, M., Jezdić, Z., Aničić, B., Sinobad, V.,& Miković, N.. (2006). Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 63(5), 457-460.
https://doi.org/10.2298/VSP0605457V

Vukadinović M, Jezdić Z, Aničić B, Sinobad V, Miković N. Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism. in Vojnosanitetski pregled. 2006;63(5):457-460.
doi:10.2298/VSP0605457V .

Vukadinović, Miroslav, Jezdić, Zoran, Aničić, Boban, Sinobad, Vladimir, Miković, Nikola, "Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism" in Vojnosanitetski pregled, 63, no. 5 (2006):457-460,
https://doi.org/10.2298/VSP0605457V . .

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Aničić, Boban
AU  - Jezdić, Zoran
AU  - Miković, Nikola
AU  - Sinobad, Vladimir
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1259
AB  - The aim of this study was to establish and estimate the effects of surgical correction of mandibular prognathism on the height and position of the upper lip. The changes of the upper lip were analyzed on 115 patients between 16 and 30 year of age (71 females and 44 males) who were subject to surgical correction of mandibular prognathism using the sagittal split ramus osteotomy. The lateral cephalometric radiographs were taken of each patient before and six months after the surgical procedure. The soft tissue cephalometric analysis included the measurements of six linear and two angular parameters. The obtained data were statistically processed and evaluated. Statistical analysis revealed the significant changes in two linear cephalometric parameters after surgical procedure - the incisal step and the length of the upper lip. The changes in the length and position of the upper lip after surgical correction of mandibular prognathism by means of sagittal split ramus osteotomy seem to be minor and clinically insignificant. Only the length of the upper lip was significantly changed. It became longer. The upper lip advancement amounted approximately 15% of the complete mandibular set-back during operation.
AB  - Cilj istraživanja je bio da utvrdi i proceni efekte hirurške korekcije mandibularnog prognatizma na dužinu i položaj gornje usne. Promene gornje usne su kefalometrijski analizirane kod 115 osoba (f=71; m=44) kod kojih je mandibularni prognatizam korigovan metodom sagitalnih osteotomija grane donje vilice. Svakom pacijentu su načinjena po dva profilna telerendgenska snimka glave, jedan pre i jedan nakon hirurške intervencije. Kefalometrijska analiza mekog profila lica je obavljena merenjem i poređenjem šest linearnih i dva angularna parametra. Dobijene vrednosti su statistički obrađene i evoluirane. Primenjene hirurške korektivne procedure rezultirale su statistički značajnim promenama kod dva linearna parametra (incizalna stepenica i dužina gornje usne). Promene gornje usne posle hirurške korekcije mandibularnog prognatizma pomoću sagitalnih klizajućih osteotomija grane donje vilice su minimalne i gotovo neznačajne. Značajno se menja jedino dužina gornje usne - postaje duža. Gornja usna se pomera za 15% ukupnog pomeranja struktura donje vilice.
PB  - Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš
T2  - Acta stomatologica Naissi
T1  - Changes of the upper lip after surgical correction of mandibular prognathism
T1  - Promene gornje usne posle hirurške korekcije progenije
VL  - 21
IS  - 52
SP  - 527
EP  - 534
UR  - https://hdl.handle.net/21.15107/rcub_smile_1259
ER  - 

@article{
author = "Vukadinović, Miroslav and Aničić, Boban and Jezdić, Zoran and Miković, Nikola and Sinobad, Vladimir",
year = "2005",
abstract = "The aim of this study was to establish and estimate the effects of surgical correction of mandibular prognathism on the height and position of the upper lip. The changes of the upper lip were analyzed on 115 patients between 16 and 30 year of age (71 females and 44 males) who were subject to surgical correction of mandibular prognathism using the sagittal split ramus osteotomy. The lateral cephalometric radiographs were taken of each patient before and six months after the surgical procedure. The soft tissue cephalometric analysis included the measurements of six linear and two angular parameters. The obtained data were statistically processed and evaluated. Statistical analysis revealed the significant changes in two linear cephalometric parameters after surgical procedure - the incisal step and the length of the upper lip. The changes in the length and position of the upper lip after surgical correction of mandibular prognathism by means of sagittal split ramus osteotomy seem to be minor and clinically insignificant. Only the length of the upper lip was significantly changed. It became longer. The upper lip advancement amounted approximately 15% of the complete mandibular set-back during operation., Cilj istraživanja je bio da utvrdi i proceni efekte hirurške korekcije mandibularnog prognatizma na dužinu i položaj gornje usne. Promene gornje usne su kefalometrijski analizirane kod 115 osoba (f=71; m=44) kod kojih je mandibularni prognatizam korigovan metodom sagitalnih osteotomija grane donje vilice. Svakom pacijentu su načinjena po dva profilna telerendgenska snimka glave, jedan pre i jedan nakon hirurške intervencije. Kefalometrijska analiza mekog profila lica je obavljena merenjem i poređenjem šest linearnih i dva angularna parametra. Dobijene vrednosti su statistički obrađene i evoluirane. Primenjene hirurške korektivne procedure rezultirale su statistički značajnim promenama kod dva linearna parametra (incizalna stepenica i dužina gornje usne). Promene gornje usne posle hirurške korekcije mandibularnog prognatizma pomoću sagitalnih klizajućih osteotomija grane donje vilice su minimalne i gotovo neznačajne. Značajno se menja jedino dužina gornje usne - postaje duža. Gornja usna se pomera za 15% ukupnog pomeranja struktura donje vilice.",
publisher = "Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš",
journal = "Acta stomatologica Naissi",
title = "Changes of the upper lip after surgical correction of mandibular prognathism, Promene gornje usne posle hirurške korekcije progenije",
volume = "21",
number = "52",
pages = "527-534",
url = "https://hdl.handle.net/21.15107/rcub_smile_1259"
}

Vukadinović, M., Aničić, B., Jezdić, Z., Miković, N.,& Sinobad, V.. (2005). Changes of the upper lip after surgical correction of mandibular prognathism. in Acta stomatologica Naissi
Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš., 21(52), 527-534.
https://hdl.handle.net/21.15107/rcub_smile_1259

Vukadinović M, Aničić B, Jezdić Z, Miković N, Sinobad V. Changes of the upper lip after surgical correction of mandibular prognathism. in Acta stomatologica Naissi. 2005;21(52):527-534.
https://hdl.handle.net/21.15107/rcub_smile_1259 .

Vukadinović, Miroslav, Aničić, Boban, Jezdić, Zoran, Miković, Nikola, Sinobad, Vladimir, "Changes of the upper lip after surgical correction of mandibular prognathism" in Acta stomatologica Naissi, 21, no. 52 (2005):527-534,
https://hdl.handle.net/21.15107/rcub_smile_1259 .

TY  - THES
AU  - Aničić, Boban
PY  - 1997
UR  - https://plus.sr.cobiss.net/opac7/bib/1024081038
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/325
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Osnove modela za evaluaciju programa preventivne stomatološke zaštite
UR  - https://hdl.handle.net/21.15107/rcub_smile_325
ER  - 

@mastersthesis{
author = "Aničić, Boban",
year = "1997",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Osnove modela za evaluaciju programa preventivne stomatološke zaštite",
url = "https://hdl.handle.net/21.15107/rcub_smile_325"
}

Aničić, B.. (1997). Osnove modela za evaluaciju programa preventivne stomatološke zaštite. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_325

Aničić B. Osnove modela za evaluaciju programa preventivne stomatološke zaštite. 1997;.
https://hdl.handle.net/21.15107/rcub_smile_325 .

Aničić, Boban, "Osnove modela za evaluaciju programa preventivne stomatološke zaštite" (1997),
https://hdl.handle.net/21.15107/rcub_smile_325 .