TY  - JOUR
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Ilic-Dimitrijević, Ivana
AU  - Eljabo, Najib
AU  - Radunović, Milena
AU  - Aničić, Boban
AU  - Tanić, Nasta
AU  - Falk, Markus
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2317
AB  - Objective. To investigate the prevalence of p16(INK4) (a), p14(ARF), tumor protein p53 (TP53), and human telomerase reverse transcriptase (hTERT) promoter hypermethylation in mucoepidermoid carcinomas (MECs) and search for a possible association between methylation status and clinicopathological parameters. Study design. DNA extracted from 35 formalin-fixed and paraffin-embedded MEC samples and 10 normal salivary gland (NSG) tissue samples was analyzed for the presence of promoter hypermethylation using methylation-specific polymerase chain reaction testing. Results. The percentages of gene hypermethylation in MECs versus NSGs were the following: p14: 100% versus 20% (P  lt  .001); p16: 60% versus 20% (P = .035); hTERT: 54.3% versus 20% (P = .078); and TP53: 31.4% versus 30% (P = .981). Multiple sites were found to be methylated in 86% of MECs compared with 10% in NSGs (P  lt  .001). TP53 and hTERT were more often methylated in lower clinical stages (P = .033 and P = .005, respectively). Conclusions. Hypermethylation of p14 appears to be an important event in the development of mucoepidermoid carcinoma. High frequency of gene hypermethylation and high incidence of methylation at multiple sites point to the importance of epigenetic phenomena in the pathogenesis of MECs, although with modest impact on clinical parameters.
PB  - Elsevier Science Inc, New York
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
T1  - P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population
VL  - 125
IS  - 1
SP  - 52
EP  - 58
DO  - 10.1016/j.oooo.2017.09.013
ER  - 

@article{
author = "Nikolić, Nadja and Čarkić, Jelena and Ilic-Dimitrijević, Ivana and Eljabo, Najib and Radunović, Milena and Aničić, Boban and Tanić, Nasta and Falk, Markus and Milašin, Jelena",
year = "2018",
abstract = "Objective. To investigate the prevalence of p16(INK4) (a), p14(ARF), tumor protein p53 (TP53), and human telomerase reverse transcriptase (hTERT) promoter hypermethylation in mucoepidermoid carcinomas (MECs) and search for a possible association between methylation status and clinicopathological parameters. Study design. DNA extracted from 35 formalin-fixed and paraffin-embedded MEC samples and 10 normal salivary gland (NSG) tissue samples was analyzed for the presence of promoter hypermethylation using methylation-specific polymerase chain reaction testing. Results. The percentages of gene hypermethylation in MECs versus NSGs were the following: p14: 100% versus 20% (P  lt  .001); p16: 60% versus 20% (P = .035); hTERT: 54.3% versus 20% (P = .078); and TP53: 31.4% versus 30% (P = .981). Multiple sites were found to be methylated in 86% of MECs compared with 10% in NSGs (P  lt  .001). TP53 and hTERT were more often methylated in lower clinical stages (P = .033 and P = .005, respectively). Conclusions. Hypermethylation of p14 appears to be an important event in the development of mucoepidermoid carcinoma. High frequency of gene hypermethylation and high incidence of methylation at multiple sites point to the importance of epigenetic phenomena in the pathogenesis of MECs, although with modest impact on clinical parameters.",
publisher = "Elsevier Science Inc, New York",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology",
title = "P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population",
volume = "125",
number = "1",
pages = "52-58",
doi = "10.1016/j.oooo.2017.09.013"
}

Nikolić, N., Čarkić, J., Ilic-Dimitrijević, I., Eljabo, N., Radunović, M., Aničić, B., Tanić, N., Falk, M.,& Milašin, J.. (2018). P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Elsevier Science Inc, New York., 125(1), 52-58.
https://doi.org/10.1016/j.oooo.2017.09.013

Nikolić N, Čarkić J, Ilic-Dimitrijević I, Eljabo N, Radunović M, Aničić B, Tanić N, Falk M, Milašin J. P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2018;125(1):52-58.
doi:10.1016/j.oooo.2017.09.013 .

Nikolić, Nadja, Čarkić, Jelena, Ilic-Dimitrijević, Ivana, Eljabo, Najib, Radunović, Milena, Aničić, Boban, Tanić, Nasta, Falk, Markus, Milašin, Jelena, "P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population" in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 125, no. 1 (2018):52-58,
https://doi.org/10.1016/j.oooo.2017.09.013 . .

TY  - JOUR
AU  - Pejčić, Nataša
AU  - Petrović, Vanja
AU  - Marković, Dejan
AU  - Miličić, Biljana
AU  - Ilic-Dimitrijević, Ivana
AU  - Perunović, Neda
AU  - Čakić, Saša
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2205
AB  - BACKGROUND: Dentists have a high prevalence of musculoskeletal (MS) pain, which is the most common symptom associated with work-related musculoskeletal disorders (WMSDs). To overcome this problem, identification of the risk factors and preventive measures for MS pain are of paramount importance to dentists in order to improve their quality of life and work. OBJECTIVES: The aims of this study were to recognize the risk factors for MS pain and their impact on dental work, as well as to identify preventive measures of MS pain among dentists. METHODS: Self-reporting questionnaire consisting of 78 questions was exclusively developed for the study and sent to 500 working active dentists in Serbia. RESULTS: Response rate was 71.2% (356 dentists). The prevalence of MS pain was 82.6% among dentists. The main risk factors for MS pain were advanced age, female dentists, presence of chronic diseases, long working hours, and high frequency of treated patients. The most effective preventive measures in preventing MS pain were massage treatments and physical activities. Followed by use of ergonomically designed equipment, correct and dynamic working positions, and an adequate workflow organization. CONCLUSION: The risk factors for MS pain and their impact on dental work should widely be disseminated among dentists. Importantly, proper implementation in everyday life of adequate preventive measures is essential for preventing MS pain and development of WMSDs.
PB  - Ios Press, Amsterdam
T2  - Work - A Journal of Prevention Assessment & Rehabilitation
T1  - Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists
VL  - 57
IS  - 4
SP  - 573
EP  - 593
DO  - 10.3233/WOR-172588
ER  - 

@article{
author = "Pejčić, Nataša and Petrović, Vanja and Marković, Dejan and Miličić, Biljana and Ilic-Dimitrijević, Ivana and Perunović, Neda and Čakić, Saša",
year = "2017",
abstract = "BACKGROUND: Dentists have a high prevalence of musculoskeletal (MS) pain, which is the most common symptom associated with work-related musculoskeletal disorders (WMSDs). To overcome this problem, identification of the risk factors and preventive measures for MS pain are of paramount importance to dentists in order to improve their quality of life and work. OBJECTIVES: The aims of this study were to recognize the risk factors for MS pain and their impact on dental work, as well as to identify preventive measures of MS pain among dentists. METHODS: Self-reporting questionnaire consisting of 78 questions was exclusively developed for the study and sent to 500 working active dentists in Serbia. RESULTS: Response rate was 71.2% (356 dentists). The prevalence of MS pain was 82.6% among dentists. The main risk factors for MS pain were advanced age, female dentists, presence of chronic diseases, long working hours, and high frequency of treated patients. The most effective preventive measures in preventing MS pain were massage treatments and physical activities. Followed by use of ergonomically designed equipment, correct and dynamic working positions, and an adequate workflow organization. CONCLUSION: The risk factors for MS pain and their impact on dental work should widely be disseminated among dentists. Importantly, proper implementation in everyday life of adequate preventive measures is essential for preventing MS pain and development of WMSDs.",
publisher = "Ios Press, Amsterdam",
journal = "Work - A Journal of Prevention Assessment & Rehabilitation",
title = "Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists",
volume = "57",
number = "4",
pages = "573-593",
doi = "10.3233/WOR-172588"
}

Pejčić, N., Petrović, V., Marković, D., Miličić, B., Ilic-Dimitrijević, I., Perunović, N.,& Čakić, S.. (2017). Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists. in Work - A Journal of Prevention Assessment & Rehabilitation
Ios Press, Amsterdam., 57(4), 573-593.
https://doi.org/10.3233/WOR-172588

Pejčić N, Petrović V, Marković D, Miličić B, Ilic-Dimitrijević I, Perunović N, Čakić S. Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists. in Work - A Journal of Prevention Assessment & Rehabilitation. 2017;57(4):573-593.
doi:10.3233/WOR-172588 .

Pejčić, Nataša, Petrović, Vanja, Marković, Dejan, Miličić, Biljana, Ilic-Dimitrijević, Ivana, Perunović, Neda, Čakić, Saša, "Assessment of risk factors and preventive measures and their relations to work-related musculoskeletal pain among dentists" in Work - A Journal of Prevention Assessment & Rehabilitation, 57, no. 4 (2017):573-593,
https://doi.org/10.3233/WOR-172588 . .

TY  - THES
AU  - Ilic-Dimitrijević, Ivana
PY  - 2016
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=3749
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:12613/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=48127759
UR  - http://nardus.mpn.gov.rs/123456789/6435
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1008
AB  - A significant number of salivary mucoepidermoid carcinoma (MEC) harbor a recurring t(11;19) translocation with an associated novel fusion oncogene (MECT1-MAML2). The MECT1-MAML2 oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of MECT1-MAML2 fusion in Serbian patients, to examine the correlation between MECT1-MAML2 status and clinico-pathological parameters of MECs, and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands and 23 cases of MEC mimics were tested for the presence of MECT1-MAML2 fusion using reverse transcriptase-polymerase chain reaction (RT-PCR). Histopatological as well as clinical parameters, disease free survival, and overall survival data were examined in relation to fusion status. MEC mimics (n=23) were defined as non-MECs and all these cases were negative for the MECT1-MAML2 fusion. In the group of confirmed MECs (n=20) the MECT1-MAML2 fusion was detected in 8 cases (40%). The presence of the MECT1-MAML2 fusion was associated with low-grade tumor histology (P = 0.02), with disease-free survival (P= 0.002) and with overall survival rate (P=0.046). The study has shown that the LG fusio-positive MECs represent unique clinico-histopatological entity, as well as that the presence of the MECT1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas.
AB  - Kod velikog broja salivarnih mukoepidermoidnih karcinoma (MEK) detektovana je rekurentna t(11;19) hromozoska translokacija čiji je proizvod novostvoreni fuzio onkogen (MECT1-MAML2). Prisustvo MECT1-MAML2 onkogena remeti normalan ćelijski ciklus i ćelijsku diferencijaciju, dovodeći do nastanka i razvoja tumora. Ciljevi ove studije bili su da se utvrdi incidenca MECT1-MAML2 fuzije kod srpskih pacijenata, zatim da se ispita odnos MECT1-MAML2 fuzije sa kliničkim i histopatološkim karakteristikama MEK-a, kao i da se utvrdi relevantnost ove fuzije kao molekularnog markera biološkog ponašanja MEK-a. U ovoj retrospektivnoj studiji, 20 slučajeva MEK-a i 23 slučajeva MEK-ovih imitacija je bilo testirano na prisustvo MECT1-MAML2 fuzije koristeći reverznu transkriptazu-polimeraznu lančanu reakciju (RT-PCR). Klinički i histopatološki parametri zajedno sa preživljavanjem bez znakova bolesti i ukupnim vremenom preživljavanja su ispitivani u odnosu na MECT1-MAML2 fuzioni status. MEK imitacije (n=23) su definisane kao ne-MEK grupa i svi slučajevi ovih karcinoma su bili negativni na MECT1-MAML2 fuziju. Kod MEK-a (n=20) fuzija je bila detektovana u 8 slučajeva (40%). Prisustvo MECT1-MAML2 fuzije je bilo povezano sa niskim histološkim gradusom tumora (P = 0.02), sa preživljavanjem bez znakova bolesti (P= 0.002) i ukupnim vremenom preživljavanja (P=0.046). Ova studija je pokazala da su LG fuzio-pozitivni MEK-i poseban kliničko-histopatološki entitet, zatim da MECT1-MAML2 fuzija može da se koristi kao pomoćni dijagnostički i prognostički marker za mukoepidermoidni karcinom.
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Analysis of chromosomal translocation T(11;19) in mucoepidermoid carcinoma of salivary glands - correlation with clinical and histopathological parameters
T1  - Analiza hromozomske translokacije T(11;19) kod mukoepidermoidnog karcinoma pljuvačnih žlezda - korelacija sa kliničkim i histopatološkim parametrima
UR  - https://hdl.handle.net/21.15107/rcub_nardus_6435
ER  - 

@phdthesis{
author = "Ilic-Dimitrijević, Ivana",
year = "2016",
abstract = "A significant number of salivary mucoepidermoid carcinoma (MEC) harbor a recurring t(11;19) translocation with an associated novel fusion oncogene (MECT1-MAML2). The MECT1-MAML2 oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of MECT1-MAML2 fusion in Serbian patients, to examine the correlation between MECT1-MAML2 status and clinico-pathological parameters of MECs, and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands and 23 cases of MEC mimics were tested for the presence of MECT1-MAML2 fusion using reverse transcriptase-polymerase chain reaction (RT-PCR). Histopatological as well as clinical parameters, disease free survival, and overall survival data were examined in relation to fusion status. MEC mimics (n=23) were defined as non-MECs and all these cases were negative for the MECT1-MAML2 fusion. In the group of confirmed MECs (n=20) the MECT1-MAML2 fusion was detected in 8 cases (40%). The presence of the MECT1-MAML2 fusion was associated with low-grade tumor histology (P = 0.02), with disease-free survival (P= 0.002) and with overall survival rate (P=0.046). The study has shown that the LG fusio-positive MECs represent unique clinico-histopatological entity, as well as that the presence of the MECT1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas., Kod velikog broja salivarnih mukoepidermoidnih karcinoma (MEK) detektovana je rekurentna t(11;19) hromozoska translokacija čiji je proizvod novostvoreni fuzio onkogen (MECT1-MAML2). Prisustvo MECT1-MAML2 onkogena remeti normalan ćelijski ciklus i ćelijsku diferencijaciju, dovodeći do nastanka i razvoja tumora. Ciljevi ove studije bili su da se utvrdi incidenca MECT1-MAML2 fuzije kod srpskih pacijenata, zatim da se ispita odnos MECT1-MAML2 fuzije sa kliničkim i histopatološkim karakteristikama MEK-a, kao i da se utvrdi relevantnost ove fuzije kao molekularnog markera biološkog ponašanja MEK-a. U ovoj retrospektivnoj studiji, 20 slučajeva MEK-a i 23 slučajeva MEK-ovih imitacija je bilo testirano na prisustvo MECT1-MAML2 fuzije koristeći reverznu transkriptazu-polimeraznu lančanu reakciju (RT-PCR). Klinički i histopatološki parametri zajedno sa preživljavanjem bez znakova bolesti i ukupnim vremenom preživljavanja su ispitivani u odnosu na MECT1-MAML2 fuzioni status. MEK imitacije (n=23) su definisane kao ne-MEK grupa i svi slučajevi ovih karcinoma su bili negativni na MECT1-MAML2 fuziju. Kod MEK-a (n=20) fuzija je bila detektovana u 8 slučajeva (40%). Prisustvo MECT1-MAML2 fuzije je bilo povezano sa niskim histološkim gradusom tumora (P = 0.02), sa preživljavanjem bez znakova bolesti (P= 0.002) i ukupnim vremenom preživljavanja (P=0.046). Ova studija je pokazala da su LG fuzio-pozitivni MEK-i poseban kliničko-histopatološki entitet, zatim da MECT1-MAML2 fuzija može da se koristi kao pomoćni dijagnostički i prognostički marker za mukoepidermoidni karcinom.",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Analysis of chromosomal translocation T(11;19) in mucoepidermoid carcinoma of salivary glands - correlation with clinical and histopathological parameters, Analiza hromozomske translokacije T(11;19) kod mukoepidermoidnog karcinoma pljuvačnih žlezda - korelacija sa kliničkim i histopatološkim parametrima",
url = "https://hdl.handle.net/21.15107/rcub_nardus_6435"
}

Ilic-Dimitrijević, I.. (2016). Analysis of chromosomal translocation T(11;19) in mucoepidermoid carcinoma of salivary glands - correlation with clinical and histopathological parameters. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_6435

Ilic-Dimitrijević I. Analysis of chromosomal translocation T(11;19) in mucoepidermoid carcinoma of salivary glands - correlation with clinical and histopathological parameters. 2016;.
https://hdl.handle.net/21.15107/rcub_nardus_6435 .

Ilic-Dimitrijević, Ivana, "Analysis of chromosomal translocation T(11;19) in mucoepidermoid carcinoma of salivary glands - correlation with clinical and histopathological parameters" (2016),
https://hdl.handle.net/21.15107/rcub_nardus_6435 .

TY  - JOUR
AU  - Ilic-Dimitrijević, Ivana
AU  - Loening, Thomas
AU  - Falk, Marcus
AU  - Konstantinović, Vitomir
AU  - Vukadinović, Miroslav
AU  - Tepavčević, Zvezdana
AU  - Tabaković, Saša Z.
AU  - Pejčić, Nataša
AU  - Miličić, Biljana
AU  - Milašin, Jelena
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1926
AB  - Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas.
PB  - Društvo genetičara Srbije, Beograd
T2  - Genetika - Belgrade
T1  - Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma
VL  - 46
IS  - 2
SP  - 601
EP  - 610
DO  - 10.2298/GENSR1402601D
ER  - 

@article{
author = "Ilic-Dimitrijević, Ivana and Loening, Thomas and Falk, Marcus and Konstantinović, Vitomir and Vukadinović, Miroslav and Tepavčević, Zvezdana and Tabaković, Saša Z. and Pejčić, Nataša and Miličić, Biljana and Milašin, Jelena",
year = "2014",
abstract = "Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas.",
publisher = "Društvo genetičara Srbije, Beograd",
journal = "Genetika - Belgrade",
title = "Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma",
volume = "46",
number = "2",
pages = "601-610",
doi = "10.2298/GENSR1402601D"
}

Ilic-Dimitrijević, I., Loening, T., Falk, M., Konstantinović, V., Vukadinović, M., Tepavčević, Z., Tabaković, S. Z., Pejčić, N., Miličić, B.,& Milašin, J.. (2014). Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma. in Genetika - Belgrade
Društvo genetičara Srbije, Beograd., 46(2), 601-610.
https://doi.org/10.2298/GENSR1402601D

Ilic-Dimitrijević I, Loening T, Falk M, Konstantinović V, Vukadinović M, Tepavčević Z, Tabaković SZ, Pejčić N, Miličić B, Milašin J. Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma. in Genetika - Belgrade. 2014;46(2):601-610.
doi:10.2298/GENSR1402601D .

Ilic-Dimitrijević, Ivana, Loening, Thomas, Falk, Marcus, Konstantinović, Vitomir, Vukadinović, Miroslav, Tepavčević, Zvezdana, Tabaković, Saša Z., Pejčić, Nataša, Miličić, Biljana, Milašin, Jelena, "Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma" in Genetika - Belgrade, 46, no. 2 (2014):601-610,
https://doi.org/10.2298/GENSR1402601D . .