TY  - JOUR
AU  - Đinić Krasavčević, Ana
AU  - Nikolić, Nadja
AU  - Mijailović, Iva
AU  - Čarkić, Jelena
AU  - Milinković, Iva
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Milašin, Jelena
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2568
AB  - Background and objective
Notch signalling cascade has recently been connected to alveolar bone resorption in periodontitis. Hence, the present cross‐sectional study aimed to analyze the expression of Notch signalling pathway (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1) and periodontitis‐related (tumor necrosis factor alpha‐ TNF‐α, interleukin 17‐IL‐17, receptor activator of nuclear factor‐kappa B ligand—RANKL, osteoprotegerin—OPG) molecules and correlate it with clinical parameters in aggressive (AP) and chronic (CP) periodontitis. Additionally, the aforementioned markers' expression was evaluated in periodontitis patients with different RANKL/OPG ratios.

Material and methods
Eighty patients were enrolled either in AP or CP group. Clinical attachment level (CAL), bleeding on probing (BOP), periodontal probing depth (PPD) and plaque index (PI) were recorded for each patient. Total RNA was extracted from gingival crevicular fluid samples. Relative gene expression of investigated markers was determined by reverse transcriptase‐real‐time polymerase chain reaction.

Results
Significantly higher values of PPD were observed in AP compared to CP (P = .010). Negative correlations between OPG and CAL, and OPG and PI, were found in AP (P = .045, P = .006, respectively), while Hey 1 and PI had a positive correlation (P = .049). In multivariate linear regression analysis, OPG and Notch 2 were predictors of CAL in AP group. TNF‐α and IL‐17 were higher in RANKL predominant than in OPG predominant cases (P = .007, P = .001, respectively). In RANKL predominant lesions Notch 1 and Jagged 1 were down‐regulated in AP compared to CP patients (P = .010, P = .025, respectively).

Conclusion
The present study demonstrated that changes in Notch 2 expression affected CAL in AP cases hence this molecule could be considered as a contributor to alveolar bone loss. In RANKL‐activated settings, the down‐regulation of Notch 1 might participate in more severe bone resorption in AP.
PB  - Wiley
T2  - Journal of Periodontal Research
T1  - Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis
VL  - 56
IS  - 1
SP  - 131
EP  - 138
DO  - 10.1111/jre.12801
ER  - 

@article{
author = "Đinić Krasavčević, Ana and Nikolić, Nadja and Mijailović, Iva and Čarkić, Jelena and Milinković, Iva and Janković, Saša and Aleksić, Zoran and Milašin, Jelena",
year = "2021",
abstract = "Background and objective
Notch signalling cascade has recently been connected to alveolar bone resorption in periodontitis. Hence, the present cross‐sectional study aimed to analyze the expression of Notch signalling pathway (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1) and periodontitis‐related (tumor necrosis factor alpha‐ TNF‐α, interleukin 17‐IL‐17, receptor activator of nuclear factor‐kappa B ligand—RANKL, osteoprotegerin—OPG) molecules and correlate it with clinical parameters in aggressive (AP) and chronic (CP) periodontitis. Additionally, the aforementioned markers' expression was evaluated in periodontitis patients with different RANKL/OPG ratios.

Material and methods
Eighty patients were enrolled either in AP or CP group. Clinical attachment level (CAL), bleeding on probing (BOP), periodontal probing depth (PPD) and plaque index (PI) were recorded for each patient. Total RNA was extracted from gingival crevicular fluid samples. Relative gene expression of investigated markers was determined by reverse transcriptase‐real‐time polymerase chain reaction.

Results
Significantly higher values of PPD were observed in AP compared to CP (P = .010). Negative correlations between OPG and CAL, and OPG and PI, were found in AP (P = .045, P = .006, respectively), while Hey 1 and PI had a positive correlation (P = .049). In multivariate linear regression analysis, OPG and Notch 2 were predictors of CAL in AP group. TNF‐α and IL‐17 were higher in RANKL predominant than in OPG predominant cases (P = .007, P = .001, respectively). In RANKL predominant lesions Notch 1 and Jagged 1 were down‐regulated in AP compared to CP patients (P = .010, P = .025, respectively).

Conclusion
The present study demonstrated that changes in Notch 2 expression affected CAL in AP cases hence this molecule could be considered as a contributor to alveolar bone loss. In RANKL‐activated settings, the down‐regulation of Notch 1 might participate in more severe bone resorption in AP.",
publisher = "Wiley",
journal = "Journal of Periodontal Research",
title = "Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis",
volume = "56",
number = "1",
pages = "131-138",
doi = "10.1111/jre.12801"
}

Đinić Krasavčević, A., Nikolić, N., Mijailović, I., Čarkić, J., Milinković, I., Janković, S., Aleksić, Z.,& Milašin, J.. (2021). Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis. in Journal of Periodontal Research
Wiley., 56(1), 131-138.
https://doi.org/10.1111/jre.12801

Đinić Krasavčević A, Nikolić N, Mijailović I, Čarkić J, Milinković I, Janković S, Aleksić Z, Milašin J. Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis. in Journal of Periodontal Research. 2021;56(1):131-138.
doi:10.1111/jre.12801 .

Đinić Krasavčević, Ana, Nikolić, Nadja, Mijailović, Iva, Čarkić, Jelena, Milinković, Iva, Janković, Saša, Aleksić, Zoran, Milašin, Jelena, "Impact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitis" in Journal of Periodontal Research, 56, no. 1 (2021):131-138,
https://doi.org/10.1111/jre.12801 . .

TY  - JOUR
AU  - Vučković, Mila
AU  - Nikolić, Nadja
AU  - Milašin, Jelena
AU  - Đorđević, Vladan
AU  - Milinković, Iva
AU  - Asotić, Jasminka
AU  - Jezdić, Zoran
AU  - Janković, Saša
AU  - Aleksić, Zoran
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2525
AB  - Introduction/Objective. The objective of the study was to investigate whether there are differences in therapeutic effect between initial treatments of chronic periodontitis [scaling and root planning (SRP)] alone and SRP in conjunction with injectable platelet-rich fibrin (I-PRF) application, comparing clinical parameters after three months. Methods. Twenty-four patients with chronic periodontitis who had at least two sites with probing pocket depth (PPD) ≥ 5 mm on contralateral side participated in the study. Using a split-mouth design, the patients were treated with SRP + I-PRF (study group) or SRP only (control group). The clinical parameters, clinical attachment level (CAL), gingival margin level (GML), PPD, bleeding on probing, and plaque index, were recorded on both sides. Results. Compared to baseline, both treatment modalities demonstrated an improvement in investigated clinical parameters. The mean value of CAL was reduced from 1.97 ± 0.75 (0.25–3.31) to 1.07 ± 0.44 (0.12–1.78) in the study group, whereas it decreased from 1.81 ± 0.66 (0.42–2.96) to 1.48 ± 0.55 (0.22–2.30) in the control group. Similarly, the corresponding values for GML and PPD showed statistically significant difference between the groups (p = 0.040 and p = 0.006, respectively). Conclusion. Regardless the limited number of patients in the study, initial periodontal therapy in conjunction with injectable platelet-rich fibrin proved to display significant improvement in all clinical parameters compared to initial periodontal therapy alone.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis
VL  - 148
IS  - 5-6
SP  - 280
EP  - 285
DO  - 10.2298/SARH190925022V
ER  - 

@article{
author = "Vučković, Mila and Nikolić, Nadja and Milašin, Jelena and Đorđević, Vladan and Milinković, Iva and Asotić, Jasminka and Jezdić, Zoran and Janković, Saša and Aleksić, Zoran",
year = "2020",
abstract = "Introduction/Objective. The objective of the study was to investigate whether there are differences in therapeutic effect between initial treatments of chronic periodontitis [scaling and root planning (SRP)] alone and SRP in conjunction with injectable platelet-rich fibrin (I-PRF) application, comparing clinical parameters after three months. Methods. Twenty-four patients with chronic periodontitis who had at least two sites with probing pocket depth (PPD) ≥ 5 mm on contralateral side participated in the study. Using a split-mouth design, the patients were treated with SRP + I-PRF (study group) or SRP only (control group). The clinical parameters, clinical attachment level (CAL), gingival margin level (GML), PPD, bleeding on probing, and plaque index, were recorded on both sides. Results. Compared to baseline, both treatment modalities demonstrated an improvement in investigated clinical parameters. The mean value of CAL was reduced from 1.97 ± 0.75 (0.25–3.31) to 1.07 ± 0.44 (0.12–1.78) in the study group, whereas it decreased from 1.81 ± 0.66 (0.42–2.96) to 1.48 ± 0.55 (0.22–2.30) in the control group. Similarly, the corresponding values for GML and PPD showed statistically significant difference between the groups (p = 0.040 and p = 0.006, respectively). Conclusion. Regardless the limited number of patients in the study, initial periodontal therapy in conjunction with injectable platelet-rich fibrin proved to display significant improvement in all clinical parameters compared to initial periodontal therapy alone.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis",
volume = "148",
number = "5-6",
pages = "280-285",
doi = "10.2298/SARH190925022V"
}

Vučković, M., Nikolić, N., Milašin, J., Đorđević, V., Milinković, I., Asotić, J., Jezdić, Z., Janković, S.,& Aleksić, Z.. (2020). The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 148(5-6), 280-285.
https://doi.org/10.2298/SARH190925022V

Vučković M, Nikolić N, Milašin J, Đorđević V, Milinković I, Asotić J, Jezdić Z, Janković S, Aleksić Z. The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis. in Srpski arhiv za celokupno lekarstvo. 2020;148(5-6):280-285.
doi:10.2298/SARH190925022V .

Vučković, Mila, Nikolić, Nadja, Milašin, Jelena, Đorđević, Vladan, Milinković, Iva, Asotić, Jasminka, Jezdić, Zoran, Janković, Saša, Aleksić, Zoran, "The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis" in Srpski arhiv za celokupno lekarstvo, 148, no. 5-6 (2020):280-285,
https://doi.org/10.2298/SARH190925022V . .

TY  - JOUR
AU  - Mijailović, Iva
AU  - Nikolić, Nadja
AU  - Đinić, Ana
AU  - Čarkić, Jelena
AU  - Milinković, Iva
AU  - Perić, Mina
AU  - Janković, Saša
AU  - Milašin, Jelena
AU  - Aleksić, Zoran
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2492
AB  - Background The exact mechanisms of bone resorption in periodontitis have not been fully elucidated. The aims of this study were to analyze the expression of Notch signaling molecules, bone remodeling mediators, and pro-inflammatory cytokines in periodontitis patients and to determine their potential correlations. Methods The study included 130 individuals: 40 with aggressive periodontitis (AP group), 40 with chronic periodontitis (CP group), and 50 periodontally healthy controls. Total RNA was extracted from gingival crevicular fluid samples and relative gene expression of investigated molecules (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1, TNF-alpha, IL-17, RANKL, and OPG) was determined by reverse transcriptase - real-time polymerase chain reaction (RT-qPCR). Results In AP group, a significant increase of Notch 2, TNF-alpha, IL-17 and RANKL and a significant decrease of Notch 1 and Jagged 1 expression were observed compared to control group (P = 0.023, P = 0.005, P = 0.030, and P = 0.001 P = 0.031 and P = 0.029, respectively). Notch 2 and RANKL were also overexpressed in CP group compared to controls (P = 0.001 and P = 0.011). Significant correlations were observed in AP group between expression levels of the analyzed genes. Conclusion The present findings implicate Notch 2 overexpression in the ethiopathogenesis of bone resorption in aggressive and chronic periodontitis. The down-regulation of Notch 1 and Jagged 1 and loss of their osteoprotective function might cause a more excessive osteoclast formation and contribute to greater osteolysis in aggressive periodontitis.
PB  - Wiley, Hoboken
T2  - Journal of Periodontology
T1  - The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis
VL  - 91
IS  - 4
SP  - 554
EP  - 561
DO  - 10.1002/JPER.18-0755
ER  - 

@article{
author = "Mijailović, Iva and Nikolić, Nadja and Đinić, Ana and Čarkić, Jelena and Milinković, Iva and Perić, Mina and Janković, Saša and Milašin, Jelena and Aleksić, Zoran",
year = "2020",
abstract = "Background The exact mechanisms of bone resorption in periodontitis have not been fully elucidated. The aims of this study were to analyze the expression of Notch signaling molecules, bone remodeling mediators, and pro-inflammatory cytokines in periodontitis patients and to determine their potential correlations. Methods The study included 130 individuals: 40 with aggressive periodontitis (AP group), 40 with chronic periodontitis (CP group), and 50 periodontally healthy controls. Total RNA was extracted from gingival crevicular fluid samples and relative gene expression of investigated molecules (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1, TNF-alpha, IL-17, RANKL, and OPG) was determined by reverse transcriptase - real-time polymerase chain reaction (RT-qPCR). Results In AP group, a significant increase of Notch 2, TNF-alpha, IL-17 and RANKL and a significant decrease of Notch 1 and Jagged 1 expression were observed compared to control group (P = 0.023, P = 0.005, P = 0.030, and P = 0.001 P = 0.031 and P = 0.029, respectively). Notch 2 and RANKL were also overexpressed in CP group compared to controls (P = 0.001 and P = 0.011). Significant correlations were observed in AP group between expression levels of the analyzed genes. Conclusion The present findings implicate Notch 2 overexpression in the ethiopathogenesis of bone resorption in aggressive and chronic periodontitis. The down-regulation of Notch 1 and Jagged 1 and loss of their osteoprotective function might cause a more excessive osteoclast formation and contribute to greater osteolysis in aggressive periodontitis.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontology",
title = "The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis",
volume = "91",
number = "4",
pages = "554-561",
doi = "10.1002/JPER.18-0755"
}

Mijailović, I., Nikolić, N., Đinić, A., Čarkić, J., Milinković, I., Perić, M., Janković, S., Milašin, J.,& Aleksić, Z.. (2020). The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis. in Journal of Periodontology
Wiley, Hoboken., 91(4), 554-561.
https://doi.org/10.1002/JPER.18-0755

Mijailović I, Nikolić N, Đinić A, Čarkić J, Milinković I, Perić M, Janković S, Milašin J, Aleksić Z. The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis. in Journal of Periodontology. 2020;91(4):554-561.
doi:10.1002/JPER.18-0755 .

Mijailović, Iva, Nikolić, Nadja, Đinić, Ana, Čarkić, Jelena, Milinković, Iva, Perić, Mina, Janković, Saša, Milašin, Jelena, Aleksić, Zoran, "The down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitis" in Journal of Periodontology, 91, no. 4 (2020):554-561,
https://doi.org/10.1002/JPER.18-0755 . .

TY  - JOUR
AU  - Rakašević, Dragana
AU  - Lazić, Zoran
AU  - Rakonjac, Bojan
AU  - Soldatović, Ivan
AU  - Janković, Saša
AU  - Magić, Marko
AU  - Aleksić, Zoran
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2174
AB  - Introduction Peri-implantitis is an inflammatory lesion of peri-implant tissues. Eradication of the causative bacteria and decontamination of the implant surface is essential in achieving predictable and stabile clinical results. Photodynamic therapy (PDT) is non-invasive adjuvant therapeutic method to surgery in the treatment of bacterial infection. Objective The aim of this study was to evaluate early clinical and microbiological outcomes of periimplantitis after surgical therapy with adjuvant PDT. Methods Fifty-two diagnosed peri-implantitis sites were divided into two groups. PDT was used for decontamination of implant surface in the study group; in the control group, chlorhexidine gel (CHX) followed by saline irrigation was applied. Several clinical parameters were recorded before the treatment (baseline values) and three months after surgical treatment. Samples for microbiological identification were collected before therapy, during the surgical therapy (before and after decontamination of implant surface), and three months thereafter, and analyzed with identification systems using biochemical analysis. Results The use of PDT resulted in significant decrease of bleeding on probing in comparison to CHX (p  lt  0.001). It showed significant decontamination of implant surfaces with complete elimination of anaerobic bacteria immediately after surgical procedure and three months later. Conclusion The results indicate that PDT can be used as an adjuvant therapy to surgery for decontamination of implant surface and surrounding peri-implant tissues within the treatment of peri-implantitis.
AB  - Uvod Periimplantitis je inflamatorni proces koji zahvata meka tkiva i potpornu kost oko oseointegrisanog implantata. Eliminacija patogenih mikroorganizama i dekontaminacija implantne površine predstavlju najbitniji korak u postizanju stabilnih kliničkih rezultata. Fotodinamska terapija (FDT) predstavlja dodatni neinvazivni metod u terapiji bakterijskih infekcija. Cilj rada Cilj rada bila je procena kliničkih i mikrobioloških parametara nakon hirurške terapije periimplantitisa uz dodatnu primenu FDT. Metode rada Sva dijagnostikovana mesta periimplantitisa (n = 52) bila su podeljena u dve grupe: u studijskoj grupi, za dekontaminaciju implantne površine tokom hirurške procedure korišćena je FDT; u kontrolnoj grupi, za dekontaminaciju implantne površine korišćen je hlorheksidin u gelu (CHX). Klinički parametri praćeni su pre terapijske procedure i tri meseca posle terapije. Uzorci za mikrobiološku analizu uzimani su pre i tri meseca posle terapije, kao i tokom hirurške procedure, pre i posle dekontaminacije implantne površine. Za identifikaciju izolovanih anaeroba korišćen je sistem koji radi po principu biohemijske analize izolovanih mikrobioloških sojeva. Rezultati studije su pokazali da primenom FDT dolazi do znatne redukcije krvarenja na provokaciju u poređenju sa primenom CHX (p  lt  0,001). Primena FDT, kao pomoćnog terapijskog sredstva, omogućava potpunu eliminaciju anaerobnih bakterija sa implantne površine. Zaključak Rezultati pokazuju da FDT može da se koristi kao pomoćno terapijsko sredstvo za dekontaminaciju implantne površine i periimplantnog tkiva u okviru terapije periimplantitisa.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial
T1  - Procena efikasnosti fotodinamske terapije u terapiji periimplantitisa posle tri meseca - randomizirana kontrolisana klinička studija
VL  - 144
IS  - 9-10
SP  - 478
EP  - 484
DO  - 10.2298/sarh1610478r
ER  - 

@article{
author = "Rakašević, Dragana and Lazić, Zoran and Rakonjac, Bojan and Soldatović, Ivan and Janković, Saša and Magić, Marko and Aleksić, Zoran",
year = "2016",
abstract = "Introduction Peri-implantitis is an inflammatory lesion of peri-implant tissues. Eradication of the causative bacteria and decontamination of the implant surface is essential in achieving predictable and stabile clinical results. Photodynamic therapy (PDT) is non-invasive adjuvant therapeutic method to surgery in the treatment of bacterial infection. Objective The aim of this study was to evaluate early clinical and microbiological outcomes of periimplantitis after surgical therapy with adjuvant PDT. Methods Fifty-two diagnosed peri-implantitis sites were divided into two groups. PDT was used for decontamination of implant surface in the study group; in the control group, chlorhexidine gel (CHX) followed by saline irrigation was applied. Several clinical parameters were recorded before the treatment (baseline values) and three months after surgical treatment. Samples for microbiological identification were collected before therapy, during the surgical therapy (before and after decontamination of implant surface), and three months thereafter, and analyzed with identification systems using biochemical analysis. Results The use of PDT resulted in significant decrease of bleeding on probing in comparison to CHX (p  lt  0.001). It showed significant decontamination of implant surfaces with complete elimination of anaerobic bacteria immediately after surgical procedure and three months later. Conclusion The results indicate that PDT can be used as an adjuvant therapy to surgery for decontamination of implant surface and surrounding peri-implant tissues within the treatment of peri-implantitis., Uvod Periimplantitis je inflamatorni proces koji zahvata meka tkiva i potpornu kost oko oseointegrisanog implantata. Eliminacija patogenih mikroorganizama i dekontaminacija implantne površine predstavlju najbitniji korak u postizanju stabilnih kliničkih rezultata. Fotodinamska terapija (FDT) predstavlja dodatni neinvazivni metod u terapiji bakterijskih infekcija. Cilj rada Cilj rada bila je procena kliničkih i mikrobioloških parametara nakon hirurške terapije periimplantitisa uz dodatnu primenu FDT. Metode rada Sva dijagnostikovana mesta periimplantitisa (n = 52) bila su podeljena u dve grupe: u studijskoj grupi, za dekontaminaciju implantne površine tokom hirurške procedure korišćena je FDT; u kontrolnoj grupi, za dekontaminaciju implantne površine korišćen je hlorheksidin u gelu (CHX). Klinički parametri praćeni su pre terapijske procedure i tri meseca posle terapije. Uzorci za mikrobiološku analizu uzimani su pre i tri meseca posle terapije, kao i tokom hirurške procedure, pre i posle dekontaminacije implantne površine. Za identifikaciju izolovanih anaeroba korišćen je sistem koji radi po principu biohemijske analize izolovanih mikrobioloških sojeva. Rezultati studije su pokazali da primenom FDT dolazi do znatne redukcije krvarenja na provokaciju u poređenju sa primenom CHX (p  lt  0,001). Primena FDT, kao pomoćnog terapijskog sredstva, omogućava potpunu eliminaciju anaerobnih bakterija sa implantne površine. Zaključak Rezultati pokazuju da FDT može da se koristi kao pomoćno terapijsko sredstvo za dekontaminaciju implantne površine i periimplantnog tkiva u okviru terapije periimplantitisa.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial, Procena efikasnosti fotodinamske terapije u terapiji periimplantitisa posle tri meseca - randomizirana kontrolisana klinička studija",
volume = "144",
number = "9-10",
pages = "478-484",
doi = "10.2298/sarh1610478r"
}

Rakašević, D., Lazić, Z., Rakonjac, B., Soldatović, I., Janković, S., Magić, M.,& Aleksić, Z.. (2016). Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 144(9-10), 478-484.
https://doi.org/10.2298/sarh1610478r

Rakašević D, Lazić Z, Rakonjac B, Soldatović I, Janković S, Magić M, Aleksić Z. Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial. in Srpski arhiv za celokupno lekarstvo. 2016;144(9-10):478-484.
doi:10.2298/sarh1610478r .

Rakašević, Dragana, Lazić, Zoran, Rakonjac, Bojan, Soldatović, Ivan, Janković, Saša, Magić, Marko, Aleksić, Zoran, "Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial" in Srpski arhiv za celokupno lekarstvo, 144, no. 9-10 (2016):478-484,
https://doi.org/10.2298/sarh1610478r . .

TY  - JOUR
AU  - Perunović, Neda
AU  - Rakić, Mia
AU  - Nikolić, Ljubinka
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Plećaš, Darko
AU  - Madianos, Phoebus N.
AU  - Čakić, Saša
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2137
AB  - Background: Periodontitis is considered to be a risk factor for preterm birth. Mechanisms have been proposed for this pathologic relation, but the exact pathologic pattern remains unclear. Therefore, the objective of the present study is to evaluate levels of four major labor triggers, prostaglandin E-2 (PGE(2)), interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha, in gingival crevicular fluid (GCF) and serum samples between women with preterm birth (PTB) and full-term birth (FTB) and correlate them with periodontal parameters. Methods: PGE(2), IL-1 beta, IL-6, and TNF-alpha levels were estimated using enzyme-linked immunosorbent assays in GCF and serum samples collected 24 to 48 hours after labor from 120 women (60 FTB, 60 PTB). Results: Women with PTB exhibited significantly more periodontitis, worse periodontal parameters, and increased GCF levels of IL-6 and PGE(2) compared with the FTB group; there were no significant differences in serum levels of measured markers. GCF levels of IL-1 beta, IL-6, and PGE(2) and serum levels of TNF-alpha and PGE(2) were significantly higher in women with periodontitis compared with periodontally healthy women. Serum levels of PGE(2) were positively correlated with probing depth (PD) and clinical attachment level (CAL) as well as with GCF levels of TNF-alpha in women with PTB. Conclusions: Women with PTB demonstrated worse periodontal parameters and significantly increased GCF levels of IL-6 and PGE(2) compared with those with FTB. Based on significant correlations among serum PGE(2) and PD, CAL, and GCF TNF-alpha in PTB, periodontitis may cause an overall increase of labor triggers and hence contribute to preterm labor onset.
PB  - Wiley, Hoboken
T2  - Journal of Periodontology
T1  - The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study
VL  - 87
IS  - 3
SP  - 248
EP  - 256
DO  - 10.1902/jop.2015.150364
ER  - 

@article{
author = "Perunović, Neda and Rakić, Mia and Nikolić, Ljubinka and Janković, Saša and Aleksić, Zoran and Plećaš, Darko and Madianos, Phoebus N. and Čakić, Saša",
year = "2016",
abstract = "Background: Periodontitis is considered to be a risk factor for preterm birth. Mechanisms have been proposed for this pathologic relation, but the exact pathologic pattern remains unclear. Therefore, the objective of the present study is to evaluate levels of four major labor triggers, prostaglandin E-2 (PGE(2)), interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha, in gingival crevicular fluid (GCF) and serum samples between women with preterm birth (PTB) and full-term birth (FTB) and correlate them with periodontal parameters. Methods: PGE(2), IL-1 beta, IL-6, and TNF-alpha levels were estimated using enzyme-linked immunosorbent assays in GCF and serum samples collected 24 to 48 hours after labor from 120 women (60 FTB, 60 PTB). Results: Women with PTB exhibited significantly more periodontitis, worse periodontal parameters, and increased GCF levels of IL-6 and PGE(2) compared with the FTB group; there were no significant differences in serum levels of measured markers. GCF levels of IL-1 beta, IL-6, and PGE(2) and serum levels of TNF-alpha and PGE(2) were significantly higher in women with periodontitis compared with periodontally healthy women. Serum levels of PGE(2) were positively correlated with probing depth (PD) and clinical attachment level (CAL) as well as with GCF levels of TNF-alpha in women with PTB. Conclusions: Women with PTB demonstrated worse periodontal parameters and significantly increased GCF levels of IL-6 and PGE(2) compared with those with FTB. Based on significant correlations among serum PGE(2) and PD, CAL, and GCF TNF-alpha in PTB, periodontitis may cause an overall increase of labor triggers and hence contribute to preterm labor onset.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontology",
title = "The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study",
volume = "87",
number = "3",
pages = "248-256",
doi = "10.1902/jop.2015.150364"
}

Perunović, N., Rakić, M., Nikolić, L., Janković, S., Aleksić, Z., Plećaš, D., Madianos, P. N.,& Čakić, S.. (2016). The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study. in Journal of Periodontology
Wiley, Hoboken., 87(3), 248-256.
https://doi.org/10.1902/jop.2015.150364

Perunović N, Rakić M, Nikolić L, Janković S, Aleksić Z, Plećaš D, Madianos PN, Čakić S. The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study. in Journal of Periodontology. 2016;87(3):248-256.
doi:10.1902/jop.2015.150364 .

Perunović, Neda, Rakić, Mia, Nikolić, Ljubinka, Janković, Saša, Aleksić, Zoran, Plećaš, Darko, Madianos, Phoebus N., Čakić, Saša, "The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study" in Journal of Periodontology, 87, no. 3 (2016):248-256,
https://doi.org/10.1902/jop.2015.150364 . .

TY  - JOUR
AU  - Cimbaljević, Milena
AU  - Spin-Neto, Rubens
AU  - Miletić, Vesna
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Nikolić-Jakoba, Nataša
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2002
AB  - Objective: The aim of this study was to compare the use of periodontal probing and cone beam computed tomography (CBCT) images in the diagnosis of furcation involvement (FI) in patients with chronic generalized severe periodontitis. Method and Materials: Fifteen patients with chronic generalized severe periodontitis were included in this study. In total, 174 furcation sites (all in molar teeth) were analyzed. FI was assessed at three sites (buccal, mesiopalatal, and distopalatal) of maxillary molars, and at two sites (buccal and oral) of mandibular molars. FI was assessed both clinically (periodontal probing) and on CBCT images, using a dichotomous scale (present/absent). The agreement between clinical and CBCT-based findings was calculated. Results: FI were more often detected by means of CBCT than by means of clinical examination. Agreement between the evaluation methods was present in 46.9% of cases (63.3% in maxilla, 45.0% in mandible). FI detected clinically was confirmed by means of CBCT in 24% of the evaluated sites. The largest agreement (73.7%) in FI detection was found in the distopalatal maxillary sites between CBCT and clinical probing. The smallest agreement (36.6%) was found in the buccal sites of the mandibular molars, in which 63.3% of FI were detected using CBCT only, but not clinically. Conclusion: The number of FI detected by means of CBCT was larger than by means of periodontal probing. In those cases in which chronic generalized severe periodontitis is clinically diagnosed, and surgical treatment is necessary, CBCT may be suggested as an adjunct tool for FI assessment.
PB  - Quintessence Publishing Co Inc, Hanover Park
T2  - Quintessence International
T1  - Clinical and CBCT-based diagnosis of furcation involvement in patients with severe periodontitis
VL  - 46
IS  - 10
SP  - 863
EP  - 870
DO  - 10.3290/j.qi.a34702
ER  - 

@article{
author = "Cimbaljević, Milena and Spin-Neto, Rubens and Miletić, Vesna and Janković, Saša and Aleksić, Zoran and Nikolić-Jakoba, Nataša",
year = "2015",
abstract = "Objective: The aim of this study was to compare the use of periodontal probing and cone beam computed tomography (CBCT) images in the diagnosis of furcation involvement (FI) in patients with chronic generalized severe periodontitis. Method and Materials: Fifteen patients with chronic generalized severe periodontitis were included in this study. In total, 174 furcation sites (all in molar teeth) were analyzed. FI was assessed at three sites (buccal, mesiopalatal, and distopalatal) of maxillary molars, and at two sites (buccal and oral) of mandibular molars. FI was assessed both clinically (periodontal probing) and on CBCT images, using a dichotomous scale (present/absent). The agreement between clinical and CBCT-based findings was calculated. Results: FI were more often detected by means of CBCT than by means of clinical examination. Agreement between the evaluation methods was present in 46.9% of cases (63.3% in maxilla, 45.0% in mandible). FI detected clinically was confirmed by means of CBCT in 24% of the evaluated sites. The largest agreement (73.7%) in FI detection was found in the distopalatal maxillary sites between CBCT and clinical probing. The smallest agreement (36.6%) was found in the buccal sites of the mandibular molars, in which 63.3% of FI were detected using CBCT only, but not clinically. Conclusion: The number of FI detected by means of CBCT was larger than by means of periodontal probing. In those cases in which chronic generalized severe periodontitis is clinically diagnosed, and surgical treatment is necessary, CBCT may be suggested as an adjunct tool for FI assessment.",
publisher = "Quintessence Publishing Co Inc, Hanover Park",
journal = "Quintessence International",
title = "Clinical and CBCT-based diagnosis of furcation involvement in patients with severe periodontitis",
volume = "46",
number = "10",
pages = "863-870",
doi = "10.3290/j.qi.a34702"
}

Cimbaljević, M., Spin-Neto, R., Miletić, V., Janković, S., Aleksić, Z.,& Nikolić-Jakoba, N.. (2015). Clinical and CBCT-based diagnosis of furcation involvement in patients with severe periodontitis. in Quintessence International
Quintessence Publishing Co Inc, Hanover Park., 46(10), 863-870.
https://doi.org/10.3290/j.qi.a34702

Cimbaljević M, Spin-Neto R, Miletić V, Janković S, Aleksić Z, Nikolić-Jakoba N. Clinical and CBCT-based diagnosis of furcation involvement in patients with severe periodontitis. in Quintessence International. 2015;46(10):863-870.
doi:10.3290/j.qi.a34702 .

Cimbaljević, Milena, Spin-Neto, Rubens, Miletić, Vesna, Janković, Saša, Aleksić, Zoran, Nikolić-Jakoba, Nataša, "Clinical and CBCT-based diagnosis of furcation involvement in patients with severe periodontitis" in Quintessence International, 46, no. 10 (2015):863-870,
https://doi.org/10.3290/j.qi.a34702 . .

TY  - JOUR
AU  - Rudolf, Rebeka
AU  - Stamenković, Dragoslav
AU  - Aleksić, Zoran
AU  - Jenko, Monika
AU  - Đorđević, Igor
AU  - Todorović, Aleksandar
AU  - Jokanović, Vukoman
AU  - Raić, Karlo T.
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1982
AB  - Thin hydroxyapatite coatings were produced on Cp-Titanium Grade-2 samples, with new high-voltage pulse-power equipment PJ-100 (Plasma Jet, Serbia) in order to get a more stable implant structure appropriate for further clinical applications. A comparative analysis of differently prepared surfaces of the Cp-Titanium Grade-2 samples was done before the hydroxyapatite was applied. Microstructural observation of the modified hydroxyapatite/implant surface was done using scanning-electron-microscopy imaging and Auger electron spectroscopy, with the aim of detecting the morphology and the elements contained in the new surfaces of the samples. The results confirmed that the surface of Cp-Titanium Grade-2 modified with hydroxyapatite is very similar to the bone structure.
PB  - Inst Za Kovinske Materiale I In Tehnologie, Ljubjana
T2  - Materiali in Tehnologije
T1  - Hydroxyapatite coatings on cp-titanium grade-2 surfaces prepared with plasma spraying
VL  - 49
IS  - 1
SP  - 81
EP  - 86
UR  - https://hdl.handle.net/21.15107/rcub_vinar_427
ER  - 

@article{
author = "Rudolf, Rebeka and Stamenković, Dragoslav and Aleksić, Zoran and Jenko, Monika and Đorđević, Igor and Todorović, Aleksandar and Jokanović, Vukoman and Raić, Karlo T.",
year = "2015",
abstract = "Thin hydroxyapatite coatings were produced on Cp-Titanium Grade-2 samples, with new high-voltage pulse-power equipment PJ-100 (Plasma Jet, Serbia) in order to get a more stable implant structure appropriate for further clinical applications. A comparative analysis of differently prepared surfaces of the Cp-Titanium Grade-2 samples was done before the hydroxyapatite was applied. Microstructural observation of the modified hydroxyapatite/implant surface was done using scanning-electron-microscopy imaging and Auger electron spectroscopy, with the aim of detecting the morphology and the elements contained in the new surfaces of the samples. The results confirmed that the surface of Cp-Titanium Grade-2 modified with hydroxyapatite is very similar to the bone structure.",
publisher = "Inst Za Kovinske Materiale I In Tehnologie, Ljubjana",
journal = "Materiali in Tehnologije",
title = "Hydroxyapatite coatings on cp-titanium grade-2 surfaces prepared with plasma spraying",
volume = "49",
number = "1",
pages = "81-86",
url = "https://hdl.handle.net/21.15107/rcub_vinar_427"
}

Rudolf, R., Stamenković, D., Aleksić, Z., Jenko, M., Đorđević, I., Todorović, A., Jokanović, V.,& Raić, K. T.. (2015). Hydroxyapatite coatings on cp-titanium grade-2 surfaces prepared with plasma spraying. in Materiali in Tehnologije
Inst Za Kovinske Materiale I In Tehnologie, Ljubjana., 49(1), 81-86.
https://hdl.handle.net/21.15107/rcub_vinar_427

Rudolf R, Stamenković D, Aleksić Z, Jenko M, Đorđević I, Todorović A, Jokanović V, Raić KT. Hydroxyapatite coatings on cp-titanium grade-2 surfaces prepared with plasma spraying. in Materiali in Tehnologije. 2015;49(1):81-86.
https://hdl.handle.net/21.15107/rcub_vinar_427 .

Rudolf, Rebeka, Stamenković, Dragoslav, Aleksić, Zoran, Jenko, Monika, Đorđević, Igor, Todorović, Aleksandar, Jokanović, Vukoman, Raić, Karlo T., "Hydroxyapatite coatings on cp-titanium grade-2 surfaces prepared with plasma spraying" in Materiali in Tehnologije, 49, no. 1 (2015):81-86,
https://hdl.handle.net/21.15107/rcub_vinar_427 .

TY  - JOUR
AU  - Milinković, Iva
AU  - Aleksić, Zoran
AU  - Janković, Saša
AU  - Popović, O.
AU  - Bajić, Miljan
AU  - Čakić, Saša
AU  - Leković, Vojislav
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1977
AB  - Background and ObjectiveGingival recession is defined as soft and hard tissue displacement resulting in root surface exposure. The optimal outcome of gingival recession treatment is complete, predictable and long-lasting root coverage with a significant level of tissue regeneration. Tissue engineering, which applies active regeneration principles, presents the contemporary treatment approach in the restitution and regeneration of lost tissues. The objective of the present study was to evaluate and compare the clinical results of application of an autologous fibroblast cell culture (AFCC) on a collagen matrix and a connective tissue graft (CTG) placed under a coronally advanced flap (CAF), in the treatment of single and multiple gingival recessions. Material and MethodsEighteen patients from the Department of Periodontology, School of Dentistry, University of Belgrade, were randomly enrolled in this study. Inclusion criteria were the bilateral presence of Miller Class I or II single or multiple maxillary gingival recessions. A split-mouth design was used in the study. The experimental group was treated with AFCC on a collagen scaffold, which was placed under a CAF. The control group received a combination of CTG and CAF. Clinical parameters such as gingival recession coverage, keratinized tissue width, clinical attachment level and gingival index were recorded at baseline and at 12mo postoperatively. The oral hygiene level was assessed by plaque index evaluation. Postoperative healing was evaluated through the healing index, recorded 1, 2 and 3wk postoperatively. The final esthetic outcome was assessed using the mean root coverage esthetic score (RES). ResultsStatistically significant improvement of all parameters assessed was found compared with baseline. A statistically significant difference between groups was observed only in keratinized tissue width. Greater keratinized tissue width is still obtained with the use of CTG. Regarding the tissue-healing results, no statistically significant difference was achieved. The RES results were similar for both groups. ConclusionsWithin the limitations of the present study, both procedures proved to be efficient in gingival recession treatment. AFCC, as a novel tissue-engineering concept and living cell-based therapy, proved to be a reliable and successful treatment concept.
PB  - Wiley, Hoboken
T2  - Journal of Periodontal Research
T1  - Clinical application of autologous fibroblast cell culture in gingival recession treatment
VL  - 50
IS  - 3
SP  - 363
EP  - 370
DO  - 10.1111/jre.12215
ER  - 

@article{
author = "Milinković, Iva and Aleksić, Zoran and Janković, Saša and Popović, O. and Bajić, Miljan and Čakić, Saša and Leković, Vojislav",
year = "2015",
abstract = "Background and ObjectiveGingival recession is defined as soft and hard tissue displacement resulting in root surface exposure. The optimal outcome of gingival recession treatment is complete, predictable and long-lasting root coverage with a significant level of tissue regeneration. Tissue engineering, which applies active regeneration principles, presents the contemporary treatment approach in the restitution and regeneration of lost tissues. The objective of the present study was to evaluate and compare the clinical results of application of an autologous fibroblast cell culture (AFCC) on a collagen matrix and a connective tissue graft (CTG) placed under a coronally advanced flap (CAF), in the treatment of single and multiple gingival recessions. Material and MethodsEighteen patients from the Department of Periodontology, School of Dentistry, University of Belgrade, were randomly enrolled in this study. Inclusion criteria were the bilateral presence of Miller Class I or II single or multiple maxillary gingival recessions. A split-mouth design was used in the study. The experimental group was treated with AFCC on a collagen scaffold, which was placed under a CAF. The control group received a combination of CTG and CAF. Clinical parameters such as gingival recession coverage, keratinized tissue width, clinical attachment level and gingival index were recorded at baseline and at 12mo postoperatively. The oral hygiene level was assessed by plaque index evaluation. Postoperative healing was evaluated through the healing index, recorded 1, 2 and 3wk postoperatively. The final esthetic outcome was assessed using the mean root coverage esthetic score (RES). ResultsStatistically significant improvement of all parameters assessed was found compared with baseline. A statistically significant difference between groups was observed only in keratinized tissue width. Greater keratinized tissue width is still obtained with the use of CTG. Regarding the tissue-healing results, no statistically significant difference was achieved. The RES results were similar for both groups. ConclusionsWithin the limitations of the present study, both procedures proved to be efficient in gingival recession treatment. AFCC, as a novel tissue-engineering concept and living cell-based therapy, proved to be a reliable and successful treatment concept.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontal Research",
title = "Clinical application of autologous fibroblast cell culture in gingival recession treatment",
volume = "50",
number = "3",
pages = "363-370",
doi = "10.1111/jre.12215"
}

Milinković, I., Aleksić, Z., Janković, S., Popović, O., Bajić, M., Čakić, S.,& Leković, V.. (2015). Clinical application of autologous fibroblast cell culture in gingival recession treatment. in Journal of Periodontal Research
Wiley, Hoboken., 50(3), 363-370.
https://doi.org/10.1111/jre.12215

Milinković I, Aleksić Z, Janković S, Popović O, Bajić M, Čakić S, Leković V. Clinical application of autologous fibroblast cell culture in gingival recession treatment. in Journal of Periodontal Research. 2015;50(3):363-370.
doi:10.1111/jre.12215 .

Milinković, Iva, Aleksić, Zoran, Janković, Saša, Popović, O., Bajić, Miljan, Čakić, Saša, Leković, Vojislav, "Clinical application of autologous fibroblast cell culture in gingival recession treatment" in Journal of Periodontal Research, 50, no. 3 (2015):363-370,
https://doi.org/10.1111/jre.12215 . .

TY  - JOUR
AU  - Perunović, Neda
AU  - Rakić, Mia
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Struillou, Xavier
AU  - Čakić, Saša
AU  - Puletić, Miljan
AU  - Leković, Vojislav
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2058
AB  - The objective of this pilot study was to investigate the potential role of-1562 C>T single nucleotide polymorphism (SNP) in the promoter region of the matrix metalloproteinase-9 (MMP-9) gene as a risk modulator in the development of multiple gingival recessions (MGRs) in young adults in the Serbian population. The study sample comprised 161 systemically healthy people: 60 with MGRs and 101 controls with healthy periodontal tissues. Genotyping was done using polymerase chain reaction/restriction fragment length polymorphism approach on DNA obtained from buccal swabs. Clinical measurements included vertical recession depth (VRD), clinical attachment level (CAL), keratinized gingival width (KGW), visible plaque index (PI), and bleeding on probing (BOP). Heterozygotes (CT) were significantly more frequent in the MGRs group than in the control group (P = .005) and carriers of the T allele had an approximately threefold increase of MGRs risk. Patients with the CT genotype exhibited significantly higher values of VRD and CAL and significantly lower values of KGW than patients with the wildtype genotype. Associations among different genotypes and periodontal biotypes in the MGRs group remained insignificant because all participants exhibited thin biotype. The 1562 C>T SNP in the promoter region of MMP-9 appears to be a risk factor for MGR development and a potential predictor of more severe clinical phenotype.
PB  - Quintessence Publishing Co. Inc.
T2  - International Journal of Periodontics & Restorative Dentistry
T1  - MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions
VL  - 35
IS  - 2
SP  - 263
EP  - 269
DO  - 10.11607/prd.2087
ER  - 

@article{
author = "Perunović, Neda and Rakić, Mia and Janković, Saša and Aleksić, Zoran and Struillou, Xavier and Čakić, Saša and Puletić, Miljan and Leković, Vojislav and Milašin, Jelena",
year = "2015",
abstract = "The objective of this pilot study was to investigate the potential role of-1562 C>T single nucleotide polymorphism (SNP) in the promoter region of the matrix metalloproteinase-9 (MMP-9) gene as a risk modulator in the development of multiple gingival recessions (MGRs) in young adults in the Serbian population. The study sample comprised 161 systemically healthy people: 60 with MGRs and 101 controls with healthy periodontal tissues. Genotyping was done using polymerase chain reaction/restriction fragment length polymorphism approach on DNA obtained from buccal swabs. Clinical measurements included vertical recession depth (VRD), clinical attachment level (CAL), keratinized gingival width (KGW), visible plaque index (PI), and bleeding on probing (BOP). Heterozygotes (CT) were significantly more frequent in the MGRs group than in the control group (P = .005) and carriers of the T allele had an approximately threefold increase of MGRs risk. Patients with the CT genotype exhibited significantly higher values of VRD and CAL and significantly lower values of KGW than patients with the wildtype genotype. Associations among different genotypes and periodontal biotypes in the MGRs group remained insignificant because all participants exhibited thin biotype. The 1562 C>T SNP in the promoter region of MMP-9 appears to be a risk factor for MGR development and a potential predictor of more severe clinical phenotype.",
publisher = "Quintessence Publishing Co. Inc.",
journal = "International Journal of Periodontics & Restorative Dentistry",
title = "MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions",
volume = "35",
number = "2",
pages = "263-269",
doi = "10.11607/prd.2087"
}

Perunović, N., Rakić, M., Janković, S., Aleksić, Z., Struillou, X., Čakić, S., Puletić, M., Leković, V.,& Milašin, J.. (2015). MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions. in International Journal of Periodontics & Restorative Dentistry
Quintessence Publishing Co. Inc.., 35(2), 263-269.
https://doi.org/10.11607/prd.2087

Perunović N, Rakić M, Janković S, Aleksić Z, Struillou X, Čakić S, Puletić M, Leković V, Milašin J. MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions. in International Journal of Periodontics & Restorative Dentistry. 2015;35(2):263-269.
doi:10.11607/prd.2087 .

Perunović, Neda, Rakić, Mia, Janković, Saša, Aleksić, Zoran, Struillou, Xavier, Čakić, Saša, Puletić, Miljan, Leković, Vojislav, Milašin, Jelena, "MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions" in International Journal of Periodontics & Restorative Dentistry, 35, no. 2 (2015):263-269,
https://doi.org/10.11607/prd.2087 . .

TY  - JOUR
AU  - Bajić, Miljan
AU  - Janković, Saša
AU  - Milinković, Iva
AU  - Čakić, Saša
AU  - Perunović, Neda
AU  - Novaković, Nada
AU  - Puletić, Miljan
AU  - Aleksić, Zoran
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1918
AB  - Introduction Gingival recession is a displacement of gingival margin apically to cement-enamel junction. Objective The aim of this study was to compare the results achieved with two different surgical procedures used in gingival recession treatment. Methods Ten patients with bilateral buccal recession on maxillary canines or premolars were included in the study. Professional teeth cleaning was performed before surgery. Recession on the experimental side was treated with connective tissue graft in combination with coronally advanced, split thickness flap (tunnel technique). Control side recession was treated with connective tissue graft in combination with trapezoidal coronally advanced, full thickness flap. Coin toss was used for side decision. The following parameters were evaluated before surgery and 6 months post-op: Vertical Recession Dimension, Clinical Attachment Level, Apico-coronal width of the keratinized tissue, Healing index (Laundry), RES index, and Patient evaluation of esthetic results. Student's t-test was used for statistical analysis. Results Six months after surgery, mean root coverage was 91.5±14.1% and 90.1±14.6% on the experimental and on the control side, respectively. RES index, Healing index (Laundry) and Patient Subjective evaluation of esthetic results showed significantly better results (p≤0.05). Conclusion Both surgical procedures produce highly successful clinical results based on evaluated parameters, but this tunnel technique provides significantly better esthetic results.
AB  - Uvod Gingivalna recesija, koja nastaje kao posledica morfoloških nepravilnosti u mukogingivalnom kompleksu, loše utiče na nastanak i prognozu parodontopatije i odlikuje se nezadovoljavajućom estetikom. Cilj rada Cilj ove studije bio je da se uporede rezultati dobijeni primenom dveju različitih hirurških tehnika u lečenju gingivalnih recesija. Metode rada U studiju je uključeno 10 pacijenata Klinike za parodontologiju i oralnu medicinu Stomatološkog fakulteta Univerziteta u Beogradu. Osnovni kriterijum za uključivanje u studiju bilo je postojanje obostranih gingivalnih recesija I ili II klase prema klasifikaciji Milera (Miller) na gornjim očnjacima ili premolarima. Izvođenje studije odobrio je Etički odbor Stomatološkog fakulteta. Ispitanici su podvrgnuti hirurškom lečenju, obostrano, primenom metoda podeljenih usta. Jedna strana tretirana je primenom transplantata vezivnog tkiva tunel- tehnikom (eksperimentalna tehnika), a druga konvencionalnom tehnikom (kontrolna tehnika). Posmatrani klinički parametri - vertikalna dimenzija gingivalne recesije, nivo pripojnog epitela i širina keratinizovane gingive - zabeleženi su pre operacije i šest meseci nakon hirurškog lečenja. Zarastanje u ranoj postoperacionoj fazi procenjivano je na osnovu vrednosti indeksa tkivnog zarastanja. Objektivna procena estetskog ishoda terapije vršena je pomoću indeksa prekrivenosti korena zuba. Rezultati Šest meseci nakon intervencije primenom eksperimentalne tehnike ostvarena je prekrivenost korena od 91,5±14,1%, dok je primenom kontrolne tehnike ostvarena pokrivenost korena od 90,1±14,6%. Parametri za objektivnu procenu postignutih estetskih rezultata i indeksa zarastanja rane pokazali su statistički značajno bolje rezultate ostvarene primenom eksperimentalne tehnike. Zaključak Obe procedure uspešne su u lečenju gingivalne recesije i daju predvidljive rezultate, ali se primenom tunel- tehnike mogu očekivati bolji estetski rezultati.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Utilization of two different surgical techniques in gingival recession treatment: A comparative study
T1  - Komparativna analiza primene dveju tehnika transplantata vezivnog tkiva u lečenju recesija gingive
VL  - 142
IS  - 3-4
SP  - 155
EP  - 163
DO  - 10.2298/SARH1404155B
ER  - 

@article{
author = "Bajić, Miljan and Janković, Saša and Milinković, Iva and Čakić, Saša and Perunović, Neda and Novaković, Nada and Puletić, Miljan and Aleksić, Zoran",
year = "2014",
abstract = "Introduction Gingival recession is a displacement of gingival margin apically to cement-enamel junction. Objective The aim of this study was to compare the results achieved with two different surgical procedures used in gingival recession treatment. Methods Ten patients with bilateral buccal recession on maxillary canines or premolars were included in the study. Professional teeth cleaning was performed before surgery. Recession on the experimental side was treated with connective tissue graft in combination with coronally advanced, split thickness flap (tunnel technique). Control side recession was treated with connective tissue graft in combination with trapezoidal coronally advanced, full thickness flap. Coin toss was used for side decision. The following parameters were evaluated before surgery and 6 months post-op: Vertical Recession Dimension, Clinical Attachment Level, Apico-coronal width of the keratinized tissue, Healing index (Laundry), RES index, and Patient evaluation of esthetic results. Student's t-test was used for statistical analysis. Results Six months after surgery, mean root coverage was 91.5±14.1% and 90.1±14.6% on the experimental and on the control side, respectively. RES index, Healing index (Laundry) and Patient Subjective evaluation of esthetic results showed significantly better results (p≤0.05). Conclusion Both surgical procedures produce highly successful clinical results based on evaluated parameters, but this tunnel technique provides significantly better esthetic results., Uvod Gingivalna recesija, koja nastaje kao posledica morfoloških nepravilnosti u mukogingivalnom kompleksu, loše utiče na nastanak i prognozu parodontopatije i odlikuje se nezadovoljavajućom estetikom. Cilj rada Cilj ove studije bio je da se uporede rezultati dobijeni primenom dveju različitih hirurških tehnika u lečenju gingivalnih recesija. Metode rada U studiju je uključeno 10 pacijenata Klinike za parodontologiju i oralnu medicinu Stomatološkog fakulteta Univerziteta u Beogradu. Osnovni kriterijum za uključivanje u studiju bilo je postojanje obostranih gingivalnih recesija I ili II klase prema klasifikaciji Milera (Miller) na gornjim očnjacima ili premolarima. Izvođenje studije odobrio je Etički odbor Stomatološkog fakulteta. Ispitanici su podvrgnuti hirurškom lečenju, obostrano, primenom metoda podeljenih usta. Jedna strana tretirana je primenom transplantata vezivnog tkiva tunel- tehnikom (eksperimentalna tehnika), a druga konvencionalnom tehnikom (kontrolna tehnika). Posmatrani klinički parametri - vertikalna dimenzija gingivalne recesije, nivo pripojnog epitela i širina keratinizovane gingive - zabeleženi su pre operacije i šest meseci nakon hirurškog lečenja. Zarastanje u ranoj postoperacionoj fazi procenjivano je na osnovu vrednosti indeksa tkivnog zarastanja. Objektivna procena estetskog ishoda terapije vršena je pomoću indeksa prekrivenosti korena zuba. Rezultati Šest meseci nakon intervencije primenom eksperimentalne tehnike ostvarena je prekrivenost korena od 91,5±14,1%, dok je primenom kontrolne tehnike ostvarena pokrivenost korena od 90,1±14,6%. Parametri za objektivnu procenu postignutih estetskih rezultata i indeksa zarastanja rane pokazali su statistički značajno bolje rezultate ostvarene primenom eksperimentalne tehnike. Zaključak Obe procedure uspešne su u lečenju gingivalne recesije i daju predvidljive rezultate, ali se primenom tunel- tehnike mogu očekivati bolji estetski rezultati.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Utilization of two different surgical techniques in gingival recession treatment: A comparative study, Komparativna analiza primene dveju tehnika transplantata vezivnog tkiva u lečenju recesija gingive",
volume = "142",
number = "3-4",
pages = "155-163",
doi = "10.2298/SARH1404155B"
}

Bajić, M., Janković, S., Milinković, I., Čakić, S., Perunović, N., Novaković, N., Puletić, M.,& Aleksić, Z.. (2014). Utilization of two different surgical techniques in gingival recession treatment: A comparative study. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(3-4), 155-163.
https://doi.org/10.2298/SARH1404155B

Bajić M, Janković S, Milinković I, Čakić S, Perunović N, Novaković N, Puletić M, Aleksić Z. Utilization of two different surgical techniques in gingival recession treatment: A comparative study. in Srpski arhiv za celokupno lekarstvo. 2014;142(3-4):155-163.
doi:10.2298/SARH1404155B .

Bajić, Miljan, Janković, Saša, Milinković, Iva, Čakić, Saša, Perunović, Neda, Novaković, Nada, Puletić, Miljan, Aleksić, Zoran, "Utilization of two different surgical techniques in gingival recession treatment: A comparative study" in Srpski arhiv za celokupno lekarstvo, 142, no. 3-4 (2014):155-163,
https://doi.org/10.2298/SARH1404155B . .

TY  - JOUR
AU  - Novaković, N.
AU  - Todorović, Tatjana
AU  - Rakić, Mia
AU  - Milinković, Iva
AU  - Dožić, Ivan
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Čakić, Saša
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1880
AB  - Background and objective: One of the major pathologic patterns in periodontitis represents an imbalance among the production of free radicals and local antioxidants resulting in periodontal tissue destruction. The objective of the study was to investigate the influence of non-surgical periodontal treatment on salivary antioxidants and to evaluate their capacity as biomarkers reflecting periodontal tissue condition and therapy outcome. Material and Methods: Sixty-three systemically healthy non-smokers, including 21 periodontally healthy subjects (HC) and 42 patients with current chronic periodontitis fulfilled the inclusion criteria. Half of the patients received scaling and root planing (SRP) and the other half received only oral hygiene instructions. Full mouth clinical measurements, including gingival index (GI), plaque index (PI), periodontal pocket depth, clinical attachment level and saliva sampling were performed at baseline visit and 2 mo after treatment/baseline visit. Total antioxidant capacity (TAOC), albumins (ALB), uric acid (UA), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were evaluated in saliva samples using commercial kits. Results: All measured antioxidants were affected by treatment resulting in significant increase in TAOC (p  lt  0.005), ALB (p  lt  0.001), UA (p  lt  0.001) and GPX (p  lt  0.001) and decrease of SOD (p  lt  0.005) in response to SRP, where no differences were observed for any of parameters in the oral hygiene instructions group. Comparison of antioxidant levels between the HC and SRP group showed that before treatment ALB were significantly higher in HC when compared to the SRP group (p = 0.039), and GXP (p = 0.000) and SOD (p = 0.021) levels were significantly higher in the SRP group. Comparison of values after treatment showed that TAOC was significantly higher in the HC than in the SRP group (p = 0.001), but UA was, inversely, significantly higher in the SRP group (p = 0.034). All clinical parameters except clinical attachment level were significantly decreased after SRP and significant correlations were observed between SOD and GI (p = 0.017), SOD and PI (p = 0.011), GPX and GI (p = 0.003) and GPX and PI (p = 0.008). Conclusion: Non-surgical periodontal treatment affected salivary TAOC, ALB, UA, SOD and GPX; moreover, these biochemical parameters convincingly reflected periodontal status and tissue response on treatment.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Periodontal Research
T1  - Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome
VL  - 49
IS  - 1
SP  - 129
EP  - 136
DO  - 10.1111/jre.12088
ER  - 

@article{
author = "Novaković, N. and Todorović, Tatjana and Rakić, Mia and Milinković, Iva and Dožić, Ivan and Janković, Saša and Aleksić, Zoran and Čakić, Saša",
year = "2014",
abstract = "Background and objective: One of the major pathologic patterns in periodontitis represents an imbalance among the production of free radicals and local antioxidants resulting in periodontal tissue destruction. The objective of the study was to investigate the influence of non-surgical periodontal treatment on salivary antioxidants and to evaluate their capacity as biomarkers reflecting periodontal tissue condition and therapy outcome. Material and Methods: Sixty-three systemically healthy non-smokers, including 21 periodontally healthy subjects (HC) and 42 patients with current chronic periodontitis fulfilled the inclusion criteria. Half of the patients received scaling and root planing (SRP) and the other half received only oral hygiene instructions. Full mouth clinical measurements, including gingival index (GI), plaque index (PI), periodontal pocket depth, clinical attachment level and saliva sampling were performed at baseline visit and 2 mo after treatment/baseline visit. Total antioxidant capacity (TAOC), albumins (ALB), uric acid (UA), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were evaluated in saliva samples using commercial kits. Results: All measured antioxidants were affected by treatment resulting in significant increase in TAOC (p  lt  0.005), ALB (p  lt  0.001), UA (p  lt  0.001) and GPX (p  lt  0.001) and decrease of SOD (p  lt  0.005) in response to SRP, where no differences were observed for any of parameters in the oral hygiene instructions group. Comparison of antioxidant levels between the HC and SRP group showed that before treatment ALB were significantly higher in HC when compared to the SRP group (p = 0.039), and GXP (p = 0.000) and SOD (p = 0.021) levels were significantly higher in the SRP group. Comparison of values after treatment showed that TAOC was significantly higher in the HC than in the SRP group (p = 0.001), but UA was, inversely, significantly higher in the SRP group (p = 0.034). All clinical parameters except clinical attachment level were significantly decreased after SRP and significant correlations were observed between SOD and GI (p = 0.017), SOD and PI (p = 0.011), GPX and GI (p = 0.003) and GPX and PI (p = 0.008). Conclusion: Non-surgical periodontal treatment affected salivary TAOC, ALB, UA, SOD and GPX; moreover, these biochemical parameters convincingly reflected periodontal status and tissue response on treatment.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Periodontal Research",
title = "Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome",
volume = "49",
number = "1",
pages = "129-136",
doi = "10.1111/jre.12088"
}

Novaković, N., Todorović, T., Rakić, M., Milinković, I., Dožić, I., Janković, S., Aleksić, Z.,& Čakić, S.. (2014). Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome. in Journal of Periodontal Research
Wiley-Blackwell, Hoboken., 49(1), 129-136.
https://doi.org/10.1111/jre.12088

Novaković N, Todorović T, Rakić M, Milinković I, Dožić I, Janković S, Aleksić Z, Čakić S. Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome. in Journal of Periodontal Research. 2014;49(1):129-136.
doi:10.1111/jre.12088 .

Novaković, N., Todorović, Tatjana, Rakić, Mia, Milinković, Iva, Dožić, Ivan, Janković, Saša, Aleksić, Zoran, Čakić, Saša, "Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome" in Journal of Periodontal Research, 49, no. 1 (2014):129-136,
https://doi.org/10.1111/jre.12088 . .

TY  - JOUR
AU  - Rakić, Mia
AU  - Nikolić-Jakoba, Nataša
AU  - Struillou, Xavier
AU  - Petković-Ćurčin, Aleksandra
AU  - Stamatović, Novak
AU  - Matić, Smiljka
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Vasilić, Đurđa
AU  - Leković, Vojislav
AU  - Vojvodić, Danilo
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1778
AB  - Background/Aim. Peri-implantitis presents inflammatory process that affects soft and hard supporting tissues of osseointegrated implant based on inflammatory osteoclastogenesis. The aim of this study was to investigate whether receptor activator of nuclear factor kappa B (RANK) concentrations in peri-implant crevicular fluid could be associated with clinical parameters that reflect inflammatory nature of peri-implantitis. Methods. The study included 67 patients, 22 with diagnosed peri-implantitis, 22 persons with healthy peri-implant tissues and 23 patients with periodontitis. Clinical parameters from each patient were recorded and samples of peri-implant/gingival crevicular fluid were collected for the enzyme-linked immunosorbent assay (ELISA) analysis. Results. RANK concentration was significantly increased in samples from the patients with periimplantitis when compared to healthy implants (p  lt  0.0001), where the average levels were 9 times higher. At the same time RANK concentration was significantly higher in periimplantitis than in periodontitis sites (p  lt  0.0001). In implant patients pocket depths and bleeding on probing values were positively associated with high RANK concentrations (p  lt  0.0001). Conclusion. These results revealed association of increased RANK concentration in samples of periimplant/ gingival crevicular fluid with peri-implant inflammation and suggests that RANK could be a pathologic determinant of peri-implantitis, thereby a potential parameter in assessment of peri-implant tissue inflammation and a potential target in designing treatment strategies.
AB  - Uvod/Cilj. Periimplantitis predstavlja inflamatorni proces koji zahvata meko i tvrdo potporno tkivo osteointegrisanog implantata, i zasnovan je na inflamatornoj osteoklastogenezi. Cilj studije bio je da se utvrdi povezanost koncentracije receptora aktivatora nuklearnog faktora kapa-B (RANK), kao glavnog receptora osteoklastnog metabolizma, sa kliničkim parametrima periimplantitisa. Metode. Studija je uključila 67 sistemski zdravih pacijenata (22 sa periimplantitisom, 22 sa zdravim implantatima i 23 sa periodontopatijom). Pacijentima su mereni klinički parametri i uziman je uzorak periimplantne/gingivalne tečnosti za određivanje koncentracije RANK-a ELISA metodom. Rezultati. Koncentracija RANK-a bila je značajno povišena kod periimplantitisa u odnosu na zdrave implantate (p  lt  0,0001), gde je srednja vrednost koncentracije bila 9 puta veća. Istovremeno, RANK je bio značajno viši kod periimplantitisa nego kod parodontopatije (p  lt  0,0001). U grupi sa implantatima dubina periodontalnog džepa i krvarenje na probu bili su pozitivno udruženi sa visokim vrednostima RANK-a (p  lt  0,0001). Zaključak. Rezultati istraživanja pokazuju udruženost povišenosti koncentracije RANK-a sa periimplantnom inflamacijom i navodi na zaključak da bi RANK mogao da bude patološka determinanta periimplantitisa, a time i potencijalni parametar za praćenje inflamacije periimplantnog tkiva i potencijalni cilj za pravljenje terapijskih strategija.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis
T1  - Receptor aktivatora nuklearnog faktora kapa B kao činilac periimplantitisa
VL  - 70
IS  - 4
SP  - 346
EP  - 351
DO  - 10.2298/VSP1304346R
ER  - 

@article{
author = "Rakić, Mia and Nikolić-Jakoba, Nataša and Struillou, Xavier and Petković-Ćurčin, Aleksandra and Stamatović, Novak and Matić, Smiljka and Janković, Saša and Aleksić, Zoran and Vasilić, Đurđa and Leković, Vojislav and Vojvodić, Danilo",
year = "2013",
abstract = "Background/Aim. Peri-implantitis presents inflammatory process that affects soft and hard supporting tissues of osseointegrated implant based on inflammatory osteoclastogenesis. The aim of this study was to investigate whether receptor activator of nuclear factor kappa B (RANK) concentrations in peri-implant crevicular fluid could be associated with clinical parameters that reflect inflammatory nature of peri-implantitis. Methods. The study included 67 patients, 22 with diagnosed peri-implantitis, 22 persons with healthy peri-implant tissues and 23 patients with periodontitis. Clinical parameters from each patient were recorded and samples of peri-implant/gingival crevicular fluid were collected for the enzyme-linked immunosorbent assay (ELISA) analysis. Results. RANK concentration was significantly increased in samples from the patients with periimplantitis when compared to healthy implants (p  lt  0.0001), where the average levels were 9 times higher. At the same time RANK concentration was significantly higher in periimplantitis than in periodontitis sites (p  lt  0.0001). In implant patients pocket depths and bleeding on probing values were positively associated with high RANK concentrations (p  lt  0.0001). Conclusion. These results revealed association of increased RANK concentration in samples of periimplant/ gingival crevicular fluid with peri-implant inflammation and suggests that RANK could be a pathologic determinant of peri-implantitis, thereby a potential parameter in assessment of peri-implant tissue inflammation and a potential target in designing treatment strategies., Uvod/Cilj. Periimplantitis predstavlja inflamatorni proces koji zahvata meko i tvrdo potporno tkivo osteointegrisanog implantata, i zasnovan je na inflamatornoj osteoklastogenezi. Cilj studije bio je da se utvrdi povezanost koncentracije receptora aktivatora nuklearnog faktora kapa-B (RANK), kao glavnog receptora osteoklastnog metabolizma, sa kliničkim parametrima periimplantitisa. Metode. Studija je uključila 67 sistemski zdravih pacijenata (22 sa periimplantitisom, 22 sa zdravim implantatima i 23 sa periodontopatijom). Pacijentima su mereni klinički parametri i uziman je uzorak periimplantne/gingivalne tečnosti za određivanje koncentracije RANK-a ELISA metodom. Rezultati. Koncentracija RANK-a bila je značajno povišena kod periimplantitisa u odnosu na zdrave implantate (p  lt  0,0001), gde je srednja vrednost koncentracije bila 9 puta veća. Istovremeno, RANK je bio značajno viši kod periimplantitisa nego kod parodontopatije (p  lt  0,0001). U grupi sa implantatima dubina periodontalnog džepa i krvarenje na probu bili su pozitivno udruženi sa visokim vrednostima RANK-a (p  lt  0,0001). Zaključak. Rezultati istraživanja pokazuju udruženost povišenosti koncentracije RANK-a sa periimplantnom inflamacijom i navodi na zaključak da bi RANK mogao da bude patološka determinanta periimplantitisa, a time i potencijalni parametar za praćenje inflamacije periimplantnog tkiva i potencijalni cilj za pravljenje terapijskih strategija.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis, Receptor aktivatora nuklearnog faktora kapa B kao činilac periimplantitisa",
volume = "70",
number = "4",
pages = "346-351",
doi = "10.2298/VSP1304346R"
}

Rakić, M., Nikolić-Jakoba, N., Struillou, X., Petković-Ćurčin, A., Stamatović, N., Matić, S., Janković, S., Aleksić, Z., Vasilić, Đ., Leković, V.,& Vojvodić, D.. (2013). Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 70(4), 346-351.
https://doi.org/10.2298/VSP1304346R

Rakić M, Nikolić-Jakoba N, Struillou X, Petković-Ćurčin A, Stamatović N, Matić S, Janković S, Aleksić Z, Vasilić Đ, Leković V, Vojvodić D. Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis. in Vojnosanitetski pregled. 2013;70(4):346-351.
doi:10.2298/VSP1304346R .

Rakić, Mia, Nikolić-Jakoba, Nataša, Struillou, Xavier, Petković-Ćurčin, Aleksandra, Stamatović, Novak, Matić, Smiljka, Janković, Saša, Aleksić, Zoran, Vasilić, Đurđa, Leković, Vojislav, Vojvodić, Danilo, "Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis" in Vojnosanitetski pregled, 70, no. 4 (2013):346-351,
https://doi.org/10.2298/VSP1304346R . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Mišić, Tijana
AU  - Miličić, Biljana
AU  - Calvo Guirado, Jose Luis
AU  - Aleksić, Zoran
AU  - Đinić, Ana
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1830
AB  - Objectives The study aimed to investigate the effect of surgical technique, implant macrodesign and insertion torque on bone temperature changes during implant placement. Material and methods In the in vitro study, 144 self-tapping (blueSKY (R) 4x10mm; Bredent) and 144 non-self-tapping (Standard implant (R) 4.1x10mm; Straumann) were placed in osteotomies prepared in pig ribs by lateral bone condensing or bone drilling techniques. The maximum insertion torque values of 30, 35 and 40Ncm were used. Real-time bone temperature measurement during implant placement was performed by three thermocouples positioned vertically, in tripod configuration around every osteotomy, at a distance of 5mm from it and at depths of 1, 5 and 10mm. Data were analysed using Kruskal-Wallis, Mann-Whitney U-tests and Regression analysis. Results Significant predictor of bone temperature at the osteotomy depth of 1mm was insertion torque (P=0.003) and at the depth of 10-mm implant macrodesign (P=0.029), while no significant predictor at depth of 5mm was identified (0.05). Higher insertion torque values as well as non-self-tapping implant macrodesign were related to higher temperatures. Implant placement in sites prepared by bone drilling induced significantly higher temperature increase (P=0.021) compared with bone condensing sites at the depth of 5mm, while no significant difference was recorded at other depths. Compared with 30Ncm, insertion torque values of 35 and 40Ncm produced significantly higher temperature increase (P=0.005; P=0.003, respectively) at the depth of 1mm. There was no significant difference in temperature change induced by 35 and 40Ncm, neither by implant macrodesign at all investigated depths (0.05). Conclusions Placement of self-tapping implants with low insertion torque into sites prepared by lateral bone condensing technique might be advantageous in terms of thermal effect on bone.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical Oral Implants Research
T1  - Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design
VL  - 24
IS  - 7
SP  - 798
EP  - 805
DO  - 10.1111/j.1600-0501.2012.02460.x
ER  - 

@article{
author = "Marković, Aleksa and Mišić, Tijana and Miličić, Biljana and Calvo Guirado, Jose Luis and Aleksić, Zoran and Đinić, Ana",
year = "2013",
abstract = "Objectives The study aimed to investigate the effect of surgical technique, implant macrodesign and insertion torque on bone temperature changes during implant placement. Material and methods In the in vitro study, 144 self-tapping (blueSKY (R) 4x10mm; Bredent) and 144 non-self-tapping (Standard implant (R) 4.1x10mm; Straumann) were placed in osteotomies prepared in pig ribs by lateral bone condensing or bone drilling techniques. The maximum insertion torque values of 30, 35 and 40Ncm were used. Real-time bone temperature measurement during implant placement was performed by three thermocouples positioned vertically, in tripod configuration around every osteotomy, at a distance of 5mm from it and at depths of 1, 5 and 10mm. Data were analysed using Kruskal-Wallis, Mann-Whitney U-tests and Regression analysis. Results Significant predictor of bone temperature at the osteotomy depth of 1mm was insertion torque (P=0.003) and at the depth of 10-mm implant macrodesign (P=0.029), while no significant predictor at depth of 5mm was identified (0.05). Higher insertion torque values as well as non-self-tapping implant macrodesign were related to higher temperatures. Implant placement in sites prepared by bone drilling induced significantly higher temperature increase (P=0.021) compared with bone condensing sites at the depth of 5mm, while no significant difference was recorded at other depths. Compared with 30Ncm, insertion torque values of 35 and 40Ncm produced significantly higher temperature increase (P=0.005; P=0.003, respectively) at the depth of 1mm. There was no significant difference in temperature change induced by 35 and 40Ncm, neither by implant macrodesign at all investigated depths (0.05). Conclusions Placement of self-tapping implants with low insertion torque into sites prepared by lateral bone condensing technique might be advantageous in terms of thermal effect on bone.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design",
volume = "24",
number = "7",
pages = "798-805",
doi = "10.1111/j.1600-0501.2012.02460.x"
}

Marković, A., Mišić, T., Miličić, B., Calvo Guirado, J. L., Aleksić, Z.,& Đinić, A.. (2013). Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design. in Clinical Oral Implants Research
Wiley-Blackwell, Hoboken., 24(7), 798-805.
https://doi.org/10.1111/j.1600-0501.2012.02460.x

Marković A, Mišić T, Miličić B, Calvo Guirado JL, Aleksić Z, Đinić A. Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design. in Clinical Oral Implants Research. 2013;24(7):798-805.
doi:10.1111/j.1600-0501.2012.02460.x .

Marković, Aleksa, Mišić, Tijana, Miličić, Biljana, Calvo Guirado, Jose Luis, Aleksić, Zoran, Đinić, Ana, "Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design" in Clinical Oral Implants Research, 24, no. 7 (2013):798-805,
https://doi.org/10.1111/j.1600-0501.2012.02460.x . .

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Dimitrijević, Božidar
AU  - Camargo, Paulo
AU  - Kenney, Barrie
AU  - Leković, Vojislav
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1844
AB  - Risk factors such as smoking, genetic factors, and tissue biotype play an important role in the etiology, predictability, and long-term stability of gingival recession treatment. This study was designed to evaluate the influence of interleukin 1 (IL-1) polymorphism and smoking on the stability of gingival recession treatment after 1 and 3 years. All patients (n = 55) were treated for type I and II recession defects using a connective tissue graft. Clinical evaluations were performed, which included assessment of vertical recession depth, gingival inflammation, and clinical attachment level. A fingerstick blood sample was collected using specially provided DNA filter paper and mailed for processing in a laboratory using polymerase chain reaction-based methodology. The results indicated that 19 subjects were genotype positive (34.5%). Treatment of the localized recessions was effective and provided a similar amount of coverage in genotype-positive and genotype-negative subjects within smoking and nonsmoking groups after 1 year. In a 3-year period, nonsmoking patients with positive IL-1 genotype lost approximately 20% of the root coverage gained at 1 year and were almost four times more inferior compared with genotype-negative patients. Patients who smoked and had a positive IL-1 genotype lost approximately 35% of the gained root coverage. IL-1 polymorphism and smoking habit did not affect gingival recession treatment at 1 year but had a great impact on long-term stability.
PB  - Quintessence Publishing Co Inc, Hanover Park
T2  - International Journal of Periodontics & Restorative Dentistry
T1  - Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment
VL  - 33
IS  - 1
SP  - E16
EP  - E23
DO  - 10.11607/prd.0823
ER  - 

@article{
author = "Janković, Saša and Aleksić, Zoran and Dimitrijević, Božidar and Camargo, Paulo and Kenney, Barrie and Leković, Vojislav",
year = "2013",
abstract = "Risk factors such as smoking, genetic factors, and tissue biotype play an important role in the etiology, predictability, and long-term stability of gingival recession treatment. This study was designed to evaluate the influence of interleukin 1 (IL-1) polymorphism and smoking on the stability of gingival recession treatment after 1 and 3 years. All patients (n = 55) were treated for type I and II recession defects using a connective tissue graft. Clinical evaluations were performed, which included assessment of vertical recession depth, gingival inflammation, and clinical attachment level. A fingerstick blood sample was collected using specially provided DNA filter paper and mailed for processing in a laboratory using polymerase chain reaction-based methodology. The results indicated that 19 subjects were genotype positive (34.5%). Treatment of the localized recessions was effective and provided a similar amount of coverage in genotype-positive and genotype-negative subjects within smoking and nonsmoking groups after 1 year. In a 3-year period, nonsmoking patients with positive IL-1 genotype lost approximately 20% of the root coverage gained at 1 year and were almost four times more inferior compared with genotype-negative patients. Patients who smoked and had a positive IL-1 genotype lost approximately 35% of the gained root coverage. IL-1 polymorphism and smoking habit did not affect gingival recession treatment at 1 year but had a great impact on long-term stability.",
publisher = "Quintessence Publishing Co Inc, Hanover Park",
journal = "International Journal of Periodontics & Restorative Dentistry",
title = "Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment",
volume = "33",
number = "1",
pages = "E16-E23",
doi = "10.11607/prd.0823"
}

Janković, S., Aleksić, Z., Dimitrijević, B., Camargo, P., Kenney, B.,& Leković, V.. (2013). Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment. in International Journal of Periodontics & Restorative Dentistry
Quintessence Publishing Co Inc, Hanover Park., 33(1), E16-E23.
https://doi.org/10.11607/prd.0823

Janković S, Aleksić Z, Dimitrijević B, Camargo P, Kenney B, Leković V. Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment. in International Journal of Periodontics & Restorative Dentistry. 2013;33(1):E16-E23.
doi:10.11607/prd.0823 .

Janković, Saša, Aleksić, Zoran, Dimitrijević, Božidar, Camargo, Paulo, Kenney, Barrie, Leković, Vojislav, "Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment" in International Journal of Periodontics & Restorative Dentistry, 33, no. 1 (2013):E16-E23,
https://doi.org/10.11607/prd.0823 . .

TY  - JOUR
AU  - Leković, Vojislav
AU  - Milinković, Iva
AU  - Aleksić, Zoran
AU  - Janković, Saša
AU  - Stanković, P.
AU  - Kenney, Barrie
AU  - Camargo, Paulo
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1762
AB  - Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, Camargo PM. Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodont Res 2012; 47: 409417. (c) 2011 John Wiley & Sons A/S Background and Objective: Bovine porous bone mineral (BPBM) is a xenograft that has been successfully utilized in periodontal regeneration. Platelet-rich fibrin (PRF) is a leukocyte and platelet preparation that concentrates various polypeptide growth factors and therefore has the potential to be used as regenerative treatment for periodontal defects. The purpose of this study was to examine the suitability of autologous PRF as regenerative treatment for periodontal intrabony defects in humans and to examine the ability of BPBM to augment the regenerative effects exerted by PRF. Material and Methods: Using a split-mouth design, 17 paired intrabony defects were randomly treated either with PRF or with PRFBPBM combination. Re-entry surgeries were performed at 6 mo. Primary study outcomes were changes in pocket depth, attachment level and defect fill. Results: Preoperative pocket depths, attachment levels and transoperative bone measurements were similar for the PRF and PRFBPBM groups. Postsurgical measurements revealed a significantly greater reduction in pocket depth in the PRFBPBM group (4.47 +/- 0.78 mm on buccal and 4.29 +/- 0.82 mm on lingual sites) when compared with the PRF group (3.35 +/- 0.68 mm on buccal and 3.24 +/- 0.73 mm on lingual sites). The PRFBPBM group presented with significantly greater attachment gain (3.82 +/- 0.78 mm on buccal and 3.71 +/- 0.75 mm on lingual sites) than the PRF group (2.24 +/- 0.73 mm on buccal and 2.12 +/- 0.68 mm on lingual sites). Defect fill was also greater in the PRFBPBM group (4.06 +/- 0.87 mm on buccal and 3.94 +/- 0.73 mm on lingual sites) than in the PRF group (2.21 +/- 0.68 mm on buccal and 2.06 +/- 0.64 mm on lingual sites). Conclusion: The results of this study indicate that PRF can improve clinical parameters associated with human intrabony periodontal defects, and BPBM has the ability to augment the effects of PRF in reducing pocket depth, improving clinical attachment levels and promoting defect fill.
PB  - Wiley, Hoboken
T2  - Journal of Periodontal Research
T1  - Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects
VL  - 47
IS  - 4
SP  - 409
EP  - 417
DO  - 10.1111/j.1600-0765.2011.01446.x
ER  - 

@article{
author = "Leković, Vojislav and Milinković, Iva and Aleksić, Zoran and Janković, Saša and Stanković, P. and Kenney, Barrie and Camargo, Paulo",
year = "2012",
abstract = "Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, Camargo PM. Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodont Res 2012; 47: 409417. (c) 2011 John Wiley & Sons A/S Background and Objective: Bovine porous bone mineral (BPBM) is a xenograft that has been successfully utilized in periodontal regeneration. Platelet-rich fibrin (PRF) is a leukocyte and platelet preparation that concentrates various polypeptide growth factors and therefore has the potential to be used as regenerative treatment for periodontal defects. The purpose of this study was to examine the suitability of autologous PRF as regenerative treatment for periodontal intrabony defects in humans and to examine the ability of BPBM to augment the regenerative effects exerted by PRF. Material and Methods: Using a split-mouth design, 17 paired intrabony defects were randomly treated either with PRF or with PRFBPBM combination. Re-entry surgeries were performed at 6 mo. Primary study outcomes were changes in pocket depth, attachment level and defect fill. Results: Preoperative pocket depths, attachment levels and transoperative bone measurements were similar for the PRF and PRFBPBM groups. Postsurgical measurements revealed a significantly greater reduction in pocket depth in the PRFBPBM group (4.47 +/- 0.78 mm on buccal and 4.29 +/- 0.82 mm on lingual sites) when compared with the PRF group (3.35 +/- 0.68 mm on buccal and 3.24 +/- 0.73 mm on lingual sites). The PRFBPBM group presented with significantly greater attachment gain (3.82 +/- 0.78 mm on buccal and 3.71 +/- 0.75 mm on lingual sites) than the PRF group (2.24 +/- 0.73 mm on buccal and 2.12 +/- 0.68 mm on lingual sites). Defect fill was also greater in the PRFBPBM group (4.06 +/- 0.87 mm on buccal and 3.94 +/- 0.73 mm on lingual sites) than in the PRF group (2.21 +/- 0.68 mm on buccal and 2.06 +/- 0.64 mm on lingual sites). Conclusion: The results of this study indicate that PRF can improve clinical parameters associated with human intrabony periodontal defects, and BPBM has the ability to augment the effects of PRF in reducing pocket depth, improving clinical attachment levels and promoting defect fill.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontal Research",
title = "Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects",
volume = "47",
number = "4",
pages = "409-417",
doi = "10.1111/j.1600-0765.2011.01446.x"
}

Leković, V., Milinković, I., Aleksić, Z., Janković, S., Stanković, P., Kenney, B.,& Camargo, P.. (2012). Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. in Journal of Periodontal Research
Wiley, Hoboken., 47(4), 409-417.
https://doi.org/10.1111/j.1600-0765.2011.01446.x

Leković V, Milinković I, Aleksić Z, Janković S, Stanković P, Kenney B, Camargo P. Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. in Journal of Periodontal Research. 2012;47(4):409-417.
doi:10.1111/j.1600-0765.2011.01446.x .

Leković, Vojislav, Milinković, Iva, Aleksić, Zoran, Janković, Saša, Stanković, P., Kenney, Barrie, Camargo, Paulo, "Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects" in Journal of Periodontal Research, 47, no. 4 (2012):409-417,
https://doi.org/10.1111/j.1600-0765.2011.01446.x . .

TY  - JOUR
AU  - Milinković, Iva
AU  - Rudolf, Rebeka
AU  - Raić, Karlo T.
AU  - Aleksić, Zoran
AU  - Lazić, Vojkan
AU  - Todorović, Aleksandar
AU  - Stamenković, Dragoslav
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1680
AB  - The shape and chemical composition, as well as the macro- and microtopography, of an implant surface have been studied widely as the major factors that positively influence implant osseointegration. Titanium and titanium alloys have been used extensively over the past 20 years as biomedical materials in orthopedic and dental surgery because of their good mechanical properties, corrosion resistance, no cell toxicity, and very poor inflammatory response in pen-implant tissue, which confirms their high biocompatibility. Their favorable biological performance is attributed to a thin native oxide film that forms spontaneously on the titanium surface. It is well established that surface roughness plays an important role in implant fixation. Accordingly, some authors have indicated the existence of an optimal range of surface roughness. The titanium surface can be either chemically or physically modified, or both, in order to improve biomaterial tissue integration. Different treatments are used to modify the titanium surface. Hydroxyapatite coatings, preceded or not by acid etching, are used to create a rough, potentially bioactive surface. Oxide blasting treatments, either with or without chemical etching, are used to develop rough surfaces. Thick oxide films obtained by anodic or thermal oxidation have been used to accelerate the osseointegration process. The ideal microtopography of the surface is still unknown, however, because it is very difficult to associate surface properties with clinical results. As more accurate knowledge is required, several Ti surfaces have been analyzed and the endosseous implant surface modified on the micro level has been thoroughly studied. Additionally, the production of gold (Au) nanoparticles to be added to the micron-scale modified surface has been performed. In this respect, an appropriate overview of our results is given.
PB  - Institute of Metals and Technology
T2  - Materiali in Tehnologije
T1  - Aspects of titanium-implant surface modification at the micro and nano levels
VL  - 46
IS  - 3
SP  - 251
EP  - 256
UR  - https://hdl.handle.net/21.15107/rcub_smile_1680
ER  - 

@article{
author = "Milinković, Iva and Rudolf, Rebeka and Raić, Karlo T. and Aleksić, Zoran and Lazić, Vojkan and Todorović, Aleksandar and Stamenković, Dragoslav",
year = "2012",
abstract = "The shape and chemical composition, as well as the macro- and microtopography, of an implant surface have been studied widely as the major factors that positively influence implant osseointegration. Titanium and titanium alloys have been used extensively over the past 20 years as biomedical materials in orthopedic and dental surgery because of their good mechanical properties, corrosion resistance, no cell toxicity, and very poor inflammatory response in pen-implant tissue, which confirms their high biocompatibility. Their favorable biological performance is attributed to a thin native oxide film that forms spontaneously on the titanium surface. It is well established that surface roughness plays an important role in implant fixation. Accordingly, some authors have indicated the existence of an optimal range of surface roughness. The titanium surface can be either chemically or physically modified, or both, in order to improve biomaterial tissue integration. Different treatments are used to modify the titanium surface. Hydroxyapatite coatings, preceded or not by acid etching, are used to create a rough, potentially bioactive surface. Oxide blasting treatments, either with or without chemical etching, are used to develop rough surfaces. Thick oxide films obtained by anodic or thermal oxidation have been used to accelerate the osseointegration process. The ideal microtopography of the surface is still unknown, however, because it is very difficult to associate surface properties with clinical results. As more accurate knowledge is required, several Ti surfaces have been analyzed and the endosseous implant surface modified on the micro level has been thoroughly studied. Additionally, the production of gold (Au) nanoparticles to be added to the micron-scale modified surface has been performed. In this respect, an appropriate overview of our results is given.",
publisher = "Institute of Metals and Technology",
journal = "Materiali in Tehnologije",
title = "Aspects of titanium-implant surface modification at the micro and nano levels",
volume = "46",
number = "3",
pages = "251-256",
url = "https://hdl.handle.net/21.15107/rcub_smile_1680"
}

Milinković, I., Rudolf, R., Raić, K. T., Aleksić, Z., Lazić, V., Todorović, A.,& Stamenković, D.. (2012). Aspects of titanium-implant surface modification at the micro and nano levels. in Materiali in Tehnologije
Institute of Metals and Technology., 46(3), 251-256.
https://hdl.handle.net/21.15107/rcub_smile_1680

Milinković I, Rudolf R, Raić KT, Aleksić Z, Lazić V, Todorović A, Stamenković D. Aspects of titanium-implant surface modification at the micro and nano levels. in Materiali in Tehnologije. 2012;46(3):251-256.
https://hdl.handle.net/21.15107/rcub_smile_1680 .

Milinković, Iva, Rudolf, Rebeka, Raić, Karlo T., Aleksić, Zoran, Lazić, Vojkan, Todorović, Aleksandar, Stamenković, Dragoslav, "Aspects of titanium-implant surface modification at the micro and nano levels" in Materiali in Tehnologije, 46, no. 3 (2012):251-256,
https://hdl.handle.net/21.15107/rcub_smile_1680 .

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Klokkevold, Perry
AU  - Leković, Vojislav
AU  - Dimitrijević, Božidar
AU  - Kenney, Barrie
AU  - Camargo, Paulo
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1690
AB  - This 6-month randomized controlled clinical study primarily aimed to compare the results achieved by the use of a platelet-rich fibrin (PRF) membrane or connective tissue graft (CTG) in the treatment of gingival recession and to evaluate the clinical impact of PRF on early wound healing and subjective patient discomfort. Use of a PRF membrane in gingival recession treatment provided acceptable clinical results, followed by enhanced wound healing and decreased subjective patient discomfort compared to CTG-treated gingival recessions. No difference could be found between PRF and CTG procedures in gingival recession therapy, except for a greater gain in keratinized tissue width obtained in the CTG group and enhanced wound healing associated with the PRF group. (Int J Periodontics Restorative Dent 2012;32:e41-e50.)
T2  - International Journal of Periodontics & Restorative Dentistry
T1  - Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial
VL  - 32
IS  - 2
SP  - e41
EP  - e50
UR  - https://hdl.handle.net/21.15107/rcub_smile_1690
ER  - 

@article{
author = "Janković, Saša and Aleksić, Zoran and Klokkevold, Perry and Leković, Vojislav and Dimitrijević, Božidar and Kenney, Barrie and Camargo, Paulo",
year = "2012",
abstract = "This 6-month randomized controlled clinical study primarily aimed to compare the results achieved by the use of a platelet-rich fibrin (PRF) membrane or connective tissue graft (CTG) in the treatment of gingival recession and to evaluate the clinical impact of PRF on early wound healing and subjective patient discomfort. Use of a PRF membrane in gingival recession treatment provided acceptable clinical results, followed by enhanced wound healing and decreased subjective patient discomfort compared to CTG-treated gingival recessions. No difference could be found between PRF and CTG procedures in gingival recession therapy, except for a greater gain in keratinized tissue width obtained in the CTG group and enhanced wound healing associated with the PRF group. (Int J Periodontics Restorative Dent 2012;32:e41-e50.)",
journal = "International Journal of Periodontics & Restorative Dentistry",
title = "Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial",
volume = "32",
number = "2",
pages = "e41-e50",
url = "https://hdl.handle.net/21.15107/rcub_smile_1690"
}

Janković, S., Aleksić, Z., Klokkevold, P., Leković, V., Dimitrijević, B., Kenney, B.,& Camargo, P.. (2012). Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial. in International Journal of Periodontics & Restorative Dentistry, 32(2), e41-e50.
https://hdl.handle.net/21.15107/rcub_smile_1690

Janković S, Aleksić Z, Klokkevold P, Leković V, Dimitrijević B, Kenney B, Camargo P. Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial. in International Journal of Periodontics & Restorative Dentistry. 2012;32(2):e41-e50.
https://hdl.handle.net/21.15107/rcub_smile_1690 .

Janković, Saša, Aleksić, Zoran, Klokkevold, Perry, Leković, Vojislav, Dimitrijević, Božidar, Kenney, Barrie, Camargo, Paulo, "Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial" in International Journal of Periodontics & Restorative Dentistry, 32, no. 2 (2012):e41-e50,
https://hdl.handle.net/21.15107/rcub_smile_1690 .

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Dimitrijević, B.
AU  - Leković, Vojislav
AU  - Milinković, Iva
AU  - Kenney, Barrie
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1615
AB  - Background: The purpose of this study was to estimate the prevalence of different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites, and to evaluate the correlation between herpesvirus presence and clinical parameters. Methods: A total of 80 dental implants ( mean time of loading, 4.16 +/- 1.8 years) were evaluated during the course of the study (30 peri-implantitis, 25 mucositis and 25 healthy peri-implant sites). The following clinical parameters were assessed: visible plaque index, bleeding on probing, suppuration and probing depth. A polymerase chain reaction (PCR) assay was used to identify the presence of different HCMV and EBV genotypes in peri-implant tissue plaque samples. Results: HCMV-2 was detected in 53.3% and EBV-1 in 46.6% of the 30 peri-implantitis sites evaluated. By contrast, HCMV-2 was not detected in healthy periodontal sites and EBV-1 was detected in one healthy site. A statistically significant correlation was found between the presence of HCMV-2 and EBV-1 genotypes and clinical parameters of peri-implantitis. Conclusions: The results from the present study confirmed the high prevalence of HCMV-2 and EBV-1 in the peri-implant tissue plaque of peri-implantitis sites and suggests a possible active pathogenic role of the viruses in peri-implantitis.
PB  - Wiley, Hoboken
T2  - Australian Dental Journal
T1  - Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status
VL  - 56
IS  - 4
SP  - 382
EP  - 388
DO  - 10.1111/j.1834-7819.2011.01360.x
ER  - 

@article{
author = "Janković, Saša and Aleksić, Zoran and Dimitrijević, B. and Leković, Vojislav and Milinković, Iva and Kenney, Barrie",
year = "2011",
abstract = "Background: The purpose of this study was to estimate the prevalence of different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites, and to evaluate the correlation between herpesvirus presence and clinical parameters. Methods: A total of 80 dental implants ( mean time of loading, 4.16 +/- 1.8 years) were evaluated during the course of the study (30 peri-implantitis, 25 mucositis and 25 healthy peri-implant sites). The following clinical parameters were assessed: visible plaque index, bleeding on probing, suppuration and probing depth. A polymerase chain reaction (PCR) assay was used to identify the presence of different HCMV and EBV genotypes in peri-implant tissue plaque samples. Results: HCMV-2 was detected in 53.3% and EBV-1 in 46.6% of the 30 peri-implantitis sites evaluated. By contrast, HCMV-2 was not detected in healthy periodontal sites and EBV-1 was detected in one healthy site. A statistically significant correlation was found between the presence of HCMV-2 and EBV-1 genotypes and clinical parameters of peri-implantitis. Conclusions: The results from the present study confirmed the high prevalence of HCMV-2 and EBV-1 in the peri-implant tissue plaque of peri-implantitis sites and suggests a possible active pathogenic role of the viruses in peri-implantitis.",
publisher = "Wiley, Hoboken",
journal = "Australian Dental Journal",
title = "Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status",
volume = "56",
number = "4",
pages = "382-388",
doi = "10.1111/j.1834-7819.2011.01360.x"
}

Janković, S., Aleksić, Z., Dimitrijević, B., Leković, V., Milinković, I.,& Kenney, B.. (2011). Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status. in Australian Dental Journal
Wiley, Hoboken., 56(4), 382-388.
https://doi.org/10.1111/j.1834-7819.2011.01360.x

Janković S, Aleksić Z, Dimitrijević B, Leković V, Milinković I, Kenney B. Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status. in Australian Dental Journal. 2011;56(4):382-388.
doi:10.1111/j.1834-7819.2011.01360.x .

Janković, Saša, Aleksić, Zoran, Dimitrijević, B., Leković, Vojislav, Milinković, Iva, Kenney, Barrie, "Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status" in Australian Dental Journal, 56, no. 4 (2011):382-388,
https://doi.org/10.1111/j.1834-7819.2011.01360.x . .

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Dimitrijević, B.
AU  - Leković, Vojislav
AU  - Camargo, Paulo
AU  - Kenney, Barrie
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1623
AB  - This study evaluated the prevalence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites and the correlation between herpesvirus and clinical parameters. Fifty-six dental implants (mean time of loading, 4.27 +/- 1.6 years) were evaluated (20 peri-implantitis, 18 mucositis, 18 healthy pen-implant sites.) The clinical parameters assessed were: visible plaque index (PI), bleeding on probing (BOP), suppuration (SUP), probing depth (PD). A polymerase chain reaction assay identified HCMV and EBV in subgingival plaque samples. The percent of sites with plaque and BOP was significantly higher around mucositis and peri-implantitis compared with healthy implants (p  lt  0.05). The mean PD around the implants was significantly higher in peri-implantitis, followed by mucositis and healthy implants (p  lt  0.05). HCMV was detected in 13 (65%) and EBV in 9 (45%) of the 20 peri-implantitis sites. HCMV was found in 1 of the 18 (6%) healthy periodontal sites and EBV in 2 (11 %). A statistically significant correlation was found between presence of HCMV and EBV subgingivally and clinical parameters of peri-implantitis and healthy sites. These results confirm the high prevalence of HCMV and EBV in subgingival plaque of peri-implantitis sites and suggest the viruses have a possible active pathogenic role in peri-implantitis.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study
VL  - 40
IS  - 3
SP  - 271
EP  - 276
DO  - 10.1016/j.ijom.2010.11.004
ER  - 

@article{
author = "Janković, Saša and Aleksić, Zoran and Dimitrijević, B. and Leković, Vojislav and Camargo, Paulo and Kenney, Barrie",
year = "2011",
abstract = "This study evaluated the prevalence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites and the correlation between herpesvirus and clinical parameters. Fifty-six dental implants (mean time of loading, 4.27 +/- 1.6 years) were evaluated (20 peri-implantitis, 18 mucositis, 18 healthy pen-implant sites.) The clinical parameters assessed were: visible plaque index (PI), bleeding on probing (BOP), suppuration (SUP), probing depth (PD). A polymerase chain reaction assay identified HCMV and EBV in subgingival plaque samples. The percent of sites with plaque and BOP was significantly higher around mucositis and peri-implantitis compared with healthy implants (p  lt  0.05). The mean PD around the implants was significantly higher in peri-implantitis, followed by mucositis and healthy implants (p  lt  0.05). HCMV was detected in 13 (65%) and EBV in 9 (45%) of the 20 peri-implantitis sites. HCMV was found in 1 of the 18 (6%) healthy periodontal sites and EBV in 2 (11 %). A statistically significant correlation was found between presence of HCMV and EBV subgingivally and clinical parameters of peri-implantitis and healthy sites. These results confirm the high prevalence of HCMV and EBV in subgingival plaque of peri-implantitis sites and suggest the viruses have a possible active pathogenic role in peri-implantitis.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study",
volume = "40",
number = "3",
pages = "271-276",
doi = "10.1016/j.ijom.2010.11.004"
}

Janković, S., Aleksić, Z., Dimitrijević, B., Leković, V., Camargo, P.,& Kenney, B.. (2011). Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 40(3), 271-276.
https://doi.org/10.1016/j.ijom.2010.11.004

Janković S, Aleksić Z, Dimitrijević B, Leković V, Camargo P, Kenney B. Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study. in International Journal of Oral & Maxillofacial Surgery. 2011;40(3):271-276.
doi:10.1016/j.ijom.2010.11.004 .

Janković, Saša, Aleksić, Zoran, Dimitrijević, B., Leković, Vojislav, Camargo, Paulo, Kenney, Barrie, "Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study" in International Journal of Oral & Maxillofacial Surgery, 40, no. 3 (2011):271-276,
https://doi.org/10.1016/j.ijom.2010.11.004 . .

TY  - JOUR
AU  - Rakić, Mia
AU  - Zelić, Ksenija
AU  - Pavlica, Dušan
AU  - Hadži-Mihailović, Miloš
AU  - Milašin, Jelena
AU  - Miličić, Biljana
AU  - Nikolić, Nebojša
AU  - Stamatović, Novak
AU  - Matić, Smiljana
AU  - Aleksić, Zoran
AU  - Janković, Saša
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1543
AB  - Background/Aim. Periodontitis is a chronic inflammatory disease of periodontal tissues with consequential is bone loss as a result of host immunological reactions caused by periopathogens. The aim of the study was to investigate if there is a correlation between clinical parameters and the presence of two most aggressive periopathogens (Aggregatibacter actinomycetemcomitans - Aa and Porphyromonas gingivalis - Pg) in patients with progressive periodontal lesions. Methods. A total of 34 systemic healthy people, 23 to 70 years old, were included in the study. The patients were clinically and radiologically examined, and after that, the representative pocket with greatest pocket depth was chosen and the sample was collected from that place. The measured clinic parameters were: gingival index, index of gingival bleeding, pocket depth and plaque indices. The multiplex Polymerase Chain Reaction (PCR) method was used for detection of periopathogens. After obtaining results, appropriate statistical tests were used to correlate the clinical and microbiological results. Results. Aa and Pg were detected in the same percentage of samples. Aa and Pg were detected in 35.29% samples alone, and in 29.41% both were detected. The values of measured clinical parameters did not show a statistical significance between the groups. In analysis of correlations among clinical parameters inside the groups, a statistical significance was found only between gingival and plaque index in the group with Aa. Conclusion. Clinical course of periodontitis in the developed stage does not differ in relation to the presence of different periopathogens as the major inductors of immunologically guided destructive processes.
AB  - Uvod/Cilj. Parodontopatija je hronično inflamatorno oboljenje parodontalnih tkiva koje za krajnji ishod ima gubitak potpornog koštanog tkiva zuba usled imunoloških reakcija izazvanih parodontopatogenim bakterijama. Cilj studije bio je korelisanje kliničkih parametara i prisustva dve najagresivnije parodontopatogene bakterije (Aggregatibacter actinomycetemcomitans - A.a. i Porphyromonas gingivalis - P.g.) kod bolesnika sa progresivnim parodontalnim lezijama. Metode. U studiju su bila uključena 34 sistemski zdrava ispitanika, starost 23-70 godina. Ispitanici su klinički i radiološki pregledani i uzorak je uziman iz reprezentativnog parodontalnog džepa sa najvećom dubinom sondiranja. Od kliničkih parametara mereni su gingivalni indeks, indeks krvarenja gingive, dubina parodontalnog džepa i indeks plaka. Prisustvo parodontopatogena dokazivano je multipleks metodom PCR (Polymerase Chain Reaction), a rezultati su korelisani sa kliničkim parametrima primenom odgovarajućih statističkih testova. Rezultati. Ista procentualna zastupljenost oba mikroorganizma dokazana je u uzorcima, naime i A.a. i P.g. bili su prisutni u po 35,39% uzoraka, a u 29,41% dokazana su oba mikroorganizma. Rezultati su korelisani po grupama formiranim u odnosu na prisustvo bakterija. Vrednosti merenih kliničkih parametara nisu se statistički značajno razlikovale u zavisnosti od prisustva parodontopatogena. Međusobne korelacije kliničkih parametara unutar grupe nisu pokazale statističku značajnost, osim korelacije gingivalnog i plak indeksa u grupi sa A.a. Zaključak. Klinički tok uznapredovale faze parodontopatije ne razlikuje se u odnosu na vrstu parodontalnih bakterija kao induktora imunološki posredovanih destruktivnih procesa.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions
T1  - Povezanost kliničkih parametara i prisustva Aggregatibacter actinomycetemcomitans i Porphyromonas gingivalis kod pacijenata sa progresivnim parodontalnim lezijama
VL  - 67
IS  - 11
SP  - 898
EP  - 902
DO  - 10.2298/VSP1011898R
ER  - 

@article{
author = "Rakić, Mia and Zelić, Ksenija and Pavlica, Dušan and Hadži-Mihailović, Miloš and Milašin, Jelena and Miličić, Biljana and Nikolić, Nebojša and Stamatović, Novak and Matić, Smiljana and Aleksić, Zoran and Janković, Saša",
year = "2010",
abstract = "Background/Aim. Periodontitis is a chronic inflammatory disease of periodontal tissues with consequential is bone loss as a result of host immunological reactions caused by periopathogens. The aim of the study was to investigate if there is a correlation between clinical parameters and the presence of two most aggressive periopathogens (Aggregatibacter actinomycetemcomitans - Aa and Porphyromonas gingivalis - Pg) in patients with progressive periodontal lesions. Methods. A total of 34 systemic healthy people, 23 to 70 years old, were included in the study. The patients were clinically and radiologically examined, and after that, the representative pocket with greatest pocket depth was chosen and the sample was collected from that place. The measured clinic parameters were: gingival index, index of gingival bleeding, pocket depth and plaque indices. The multiplex Polymerase Chain Reaction (PCR) method was used for detection of periopathogens. After obtaining results, appropriate statistical tests were used to correlate the clinical and microbiological results. Results. Aa and Pg were detected in the same percentage of samples. Aa and Pg were detected in 35.29% samples alone, and in 29.41% both were detected. The values of measured clinical parameters did not show a statistical significance between the groups. In analysis of correlations among clinical parameters inside the groups, a statistical significance was found only between gingival and plaque index in the group with Aa. Conclusion. Clinical course of periodontitis in the developed stage does not differ in relation to the presence of different periopathogens as the major inductors of immunologically guided destructive processes., Uvod/Cilj. Parodontopatija je hronično inflamatorno oboljenje parodontalnih tkiva koje za krajnji ishod ima gubitak potpornog koštanog tkiva zuba usled imunoloških reakcija izazvanih parodontopatogenim bakterijama. Cilj studije bio je korelisanje kliničkih parametara i prisustva dve najagresivnije parodontopatogene bakterije (Aggregatibacter actinomycetemcomitans - A.a. i Porphyromonas gingivalis - P.g.) kod bolesnika sa progresivnim parodontalnim lezijama. Metode. U studiju su bila uključena 34 sistemski zdrava ispitanika, starost 23-70 godina. Ispitanici su klinički i radiološki pregledani i uzorak je uziman iz reprezentativnog parodontalnog džepa sa najvećom dubinom sondiranja. Od kliničkih parametara mereni su gingivalni indeks, indeks krvarenja gingive, dubina parodontalnog džepa i indeks plaka. Prisustvo parodontopatogena dokazivano je multipleks metodom PCR (Polymerase Chain Reaction), a rezultati su korelisani sa kliničkim parametrima primenom odgovarajućih statističkih testova. Rezultati. Ista procentualna zastupljenost oba mikroorganizma dokazana je u uzorcima, naime i A.a. i P.g. bili su prisutni u po 35,39% uzoraka, a u 29,41% dokazana su oba mikroorganizma. Rezultati su korelisani po grupama formiranim u odnosu na prisustvo bakterija. Vrednosti merenih kliničkih parametara nisu se statistički značajno razlikovale u zavisnosti od prisustva parodontopatogena. Međusobne korelacije kliničkih parametara unutar grupe nisu pokazale statističku značajnost, osim korelacije gingivalnog i plak indeksa u grupi sa A.a. Zaključak. Klinički tok uznapredovale faze parodontopatije ne razlikuje se u odnosu na vrstu parodontalnih bakterija kao induktora imunološki posredovanih destruktivnih procesa.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions, Povezanost kliničkih parametara i prisustva Aggregatibacter actinomycetemcomitans i Porphyromonas gingivalis kod pacijenata sa progresivnim parodontalnim lezijama",
volume = "67",
number = "11",
pages = "898-902",
doi = "10.2298/VSP1011898R"
}

Rakić, M., Zelić, K., Pavlica, D., Hadži-Mihailović, M., Milašin, J., Miličić, B., Nikolić, N., Stamatović, N., Matić, S., Aleksić, Z.,& Janković, S.. (2010). Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 67(11), 898-902.
https://doi.org/10.2298/VSP1011898R

Rakić M, Zelić K, Pavlica D, Hadži-Mihailović M, Milašin J, Miličić B, Nikolić N, Stamatović N, Matić S, Aleksić Z, Janković S. Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions. in Vojnosanitetski pregled. 2010;67(11):898-902.
doi:10.2298/VSP1011898R .

Rakić, Mia, Zelić, Ksenija, Pavlica, Dušan, Hadži-Mihailović, Miloš, Milašin, Jelena, Miličić, Biljana, Nikolić, Nebojša, Stamatović, Novak, Matić, Smiljana, Aleksić, Zoran, Janković, Saša, "Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions" in Vojnosanitetski pregled, 67, no. 11 (2010):898-902,
https://doi.org/10.2298/VSP1011898R . .

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Nikolić-Jakoba, Nataša
AU  - Stanimirović, Dragan
AU  - Stojić, Ž.
AU  - Pucar, Ana
AU  - Hadži-Mihailović, Miloš
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1585
AB  - Periodontal disease is a chronic, multi-factorial disease of the tissues supporting the teeth. Periodontitis in companion animals is an almost identical disease to that in humans in terms of disease course and clinical presentation. Receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) are bioactive molecules that control bone resorption. This study aims to evaluate the effect of Chlorhexidine (CXD) on the RANKL and OPG expressions in gingival crevicular fluid (GCF) collected from subjects with chronic periodontitis. GCF was obtained from subjects with chronic periodontitis.10 subjects (CXD1) rinsed the mouth with 0.12% CXD, 10 subjects (CXD2) utilized 0.20% CXD and the last 10 (PL) used Placebo solution for 7 days. RANKL and OPG concentrations in GCF were measured by enzyme-linked immunosorbent assays ELISA at baseline and after 7 days. Periodontal clinical variables: clinical attachment loss (CAL), probing pocket depth (PPD), papilla-bleeding index (PBI) were evaluated in all groups. After 7 days in CXD1 and CXD2 group RANKL/OPG ratio exhibited a significant decrease (p lt 0.05) in contrast to the PL group where results showed similar values of RANKL/OPG ratio at baseline and after the observation period. RANKL/OPG ratio was positively correlated with PPD, CAL and PBI before and after the observation period in both Chlorhexidine (CXD1, CXD2) groups. In an existing inflammatory response, chlorhexidine reduced the level of periodontal inflammation, which leads to reduction of RANKL/OPG relative ratio. Decrease of RANKL/OPG ratio will apparently induce maintenance of alveolar bone and slow down periodontal tissue breakdown.
AB  - Parodontopatije su hronična, multikauzalna oboljenja potpornog aparata zuba. Parodontalna oboljenja koja srećemo kod kućnih ljubimaca su prema toku i kliničkoj slici skoro identična onima koje se javljaju kod ljudi. RANKL i osteoprotegerin (OPG) su bioaktivni molekuli koji kontrolišu koštanu resorpciju. Cilj ove studije je evaluacija efekata hlorheksidina na ekspresiju RANKL-a i OPG-a u gingivalnoj tečnosti (GT) uzetoj od pacijenata sa hroničnom parodontopatijom. 10 pacijenata (CXD1) su ispirali usta sa 0.12% CXD, 10 pacijenata (CXD2) su koristili 0.20% CXD i poslednjih 10 pacijenata (PL) su koristili placebo rastvor 7 dana. RANKL i OPG koncentracije u GT su merene ELISA testom na početku i posle sedam dana. Parodontalni klinički parametri CAL, PPD i PBI su evaluirani u svim grupama. Posle 7 dana u CXD1 i CXD2 grupi RANKL/OPG odnos je pokazao signifikantno smanjenje (p lt 0.05) u poređenju sa PL grupom gde su zabaleženi slični rezultati na početku i nakon opservacionog perioda. RANKL/OPG odnos je pokazao pozitivnu korelaciju sa vrednostima PPD-a, CAL-a i PBI-a pre i nakon observacionog perioda u obe eksperimentalne grupe (CXD1, CXD2). U prisutnom inflamatornom odgovoru hlorheksidin je redukovao nivo inflamacije, što je uslovilo redukciju RANKL/OPG odnosa. Rezultati istraživanja dokazuju da koncentracija hlorheksidina ne utiče statistički značajno na smanjenje RANKL/OPG odnosa.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals
T1  - Efekat hlorheksidina na ekspresiju receptor aktivatora NF-kb liganda (RANKL) i osteoprotežerina (OPG) kod ljudi i kućnih ljubimaca
VL  - 60
IS  - 5-6
SP  - 641
EP  - 652
DO  - 10.2298/AVB1006641J
ER  - 

@article{
author = "Janković, Saša and Aleksić, Zoran and Nikolić-Jakoba, Nataša and Stanimirović, Dragan and Stojić, Ž. and Pucar, Ana and Hadži-Mihailović, Miloš",
year = "2010",
abstract = "Periodontal disease is a chronic, multi-factorial disease of the tissues supporting the teeth. Periodontitis in companion animals is an almost identical disease to that in humans in terms of disease course and clinical presentation. Receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) are bioactive molecules that control bone resorption. This study aims to evaluate the effect of Chlorhexidine (CXD) on the RANKL and OPG expressions in gingival crevicular fluid (GCF) collected from subjects with chronic periodontitis. GCF was obtained from subjects with chronic periodontitis.10 subjects (CXD1) rinsed the mouth with 0.12% CXD, 10 subjects (CXD2) utilized 0.20% CXD and the last 10 (PL) used Placebo solution for 7 days. RANKL and OPG concentrations in GCF were measured by enzyme-linked immunosorbent assays ELISA at baseline and after 7 days. Periodontal clinical variables: clinical attachment loss (CAL), probing pocket depth (PPD), papilla-bleeding index (PBI) were evaluated in all groups. After 7 days in CXD1 and CXD2 group RANKL/OPG ratio exhibited a significant decrease (p lt 0.05) in contrast to the PL group where results showed similar values of RANKL/OPG ratio at baseline and after the observation period. RANKL/OPG ratio was positively correlated with PPD, CAL and PBI before and after the observation period in both Chlorhexidine (CXD1, CXD2) groups. In an existing inflammatory response, chlorhexidine reduced the level of periodontal inflammation, which leads to reduction of RANKL/OPG relative ratio. Decrease of RANKL/OPG ratio will apparently induce maintenance of alveolar bone and slow down periodontal tissue breakdown., Parodontopatije su hronična, multikauzalna oboljenja potpornog aparata zuba. Parodontalna oboljenja koja srećemo kod kućnih ljubimaca su prema toku i kliničkoj slici skoro identična onima koje se javljaju kod ljudi. RANKL i osteoprotegerin (OPG) su bioaktivni molekuli koji kontrolišu koštanu resorpciju. Cilj ove studije je evaluacija efekata hlorheksidina na ekspresiju RANKL-a i OPG-a u gingivalnoj tečnosti (GT) uzetoj od pacijenata sa hroničnom parodontopatijom. 10 pacijenata (CXD1) su ispirali usta sa 0.12% CXD, 10 pacijenata (CXD2) su koristili 0.20% CXD i poslednjih 10 pacijenata (PL) su koristili placebo rastvor 7 dana. RANKL i OPG koncentracije u GT su merene ELISA testom na početku i posle sedam dana. Parodontalni klinički parametri CAL, PPD i PBI su evaluirani u svim grupama. Posle 7 dana u CXD1 i CXD2 grupi RANKL/OPG odnos je pokazao signifikantno smanjenje (p lt 0.05) u poređenju sa PL grupom gde su zabaleženi slični rezultati na početku i nakon opservacionog perioda. RANKL/OPG odnos je pokazao pozitivnu korelaciju sa vrednostima PPD-a, CAL-a i PBI-a pre i nakon observacionog perioda u obe eksperimentalne grupe (CXD1, CXD2). U prisutnom inflamatornom odgovoru hlorheksidin je redukovao nivo inflamacije, što je uslovilo redukciju RANKL/OPG odnosa. Rezultati istraživanja dokazuju da koncentracija hlorheksidina ne utiče statistički značajno na smanjenje RANKL/OPG odnosa.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals, Efekat hlorheksidina na ekspresiju receptor aktivatora NF-kb liganda (RANKL) i osteoprotežerina (OPG) kod ljudi i kućnih ljubimaca",
volume = "60",
number = "5-6",
pages = "641-652",
doi = "10.2298/AVB1006641J"
}

Janković, S., Aleksić, Z., Nikolić-Jakoba, N., Stanimirović, D., Stojić, Ž., Pucar, A.,& Hadži-Mihailović, M.. (2010). The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 60(5-6), 641-652.
https://doi.org/10.2298/AVB1006641J

Janković S, Aleksić Z, Nikolić-Jakoba N, Stanimirović D, Stojić Ž, Pucar A, Hadži-Mihailović M. The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals. in Acta veterinaria. 2010;60(5-6):641-652.
doi:10.2298/AVB1006641J .

Janković, Saša, Aleksić, Zoran, Nikolić-Jakoba, Nataša, Stanimirović, Dragan, Stojić, Ž., Pucar, Ana, Hadži-Mihailović, Miloš, "The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals" in Acta veterinaria, 60, no. 5-6 (2010):641-652,
https://doi.org/10.2298/AVB1006641J . .

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Milinković, Iva
AU  - Dimitrijević, B.
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1595
AB  - The main objective of this study was to evaluate the clinical effectiveness of platelet-rich fibrin membrane used in combination with a coronally advanced flap (CAF) and to compare it with the use of an enamel matrix derivative (EMD) in combination with a coronally advanced flap in gingival recession treatment. 20 split-mouth cases of maxillary anterior teeth or bicuspids presenting with Miller Class I or II gingival recession were treated with a CAF combined with a platelet-rich fibrin membrane (PRF group) or with EMD (EMD group) placed under a CAF. The following parameters were measured at baseline and at 12 months post treatment: gingival recession (GR), apicocoronal width of the keratinized tissue (WKT), and probing depth (PD). Complete rot coverage in the PRF group was 65% (13 out of 20 recessions) and 60% in the EMD group (12 out of 20 recessions). GR was 4.10 ± 1.05 mm in the PRF group and 3.90 ± 1.00 mm in the EMD group at baseline, and 1.05 ± 0.45 mm in the PRF group and 1.15 ± 0.65 mm in the EMD group at 12 months. The difference observed between the tow groups at 12 months was statistically significant. Average root coverage was 70.5% in the EMD group and 72.1% in the PRF group. WKT was 1.30 ± 0.56 mm in the EMD group and 1.45 ± 0.86 mm in the PRF group at baseline, and 1.90 ± 0.81 mm in the EMD group and 1.62 ± 0.28 mm in the PRF group at 12 months. The difference observed between the two groups at 12 months was not statistically significant. Twelve-month changes in PD were not significantly different between the two groups. The pain intensity was statistically different between the two groups. The pain intensity was statistically different between groups for the first 5 days, favoring the PRF group. The present study did not succeed in demonstrating any clinical advantage of the use of PRF compared to EMD in the coverage of gingival recession with the CAF procedure. The EMD group showed a higher success rate in increasing WKT than did the PRF group.
T2  - The European Journal of Esthetic Dentistry
T1  - The coronally advanced flap in combination with platelet-rich fibrin (PRF) and enamel matrix derivative in the treatment of gingival recession: a comparative study.
VL  - 5
IS  - 3
SP  - 260
EP  - 273
UR  - https://hdl.handle.net/21.15107/rcub_smile_1595
ER  - 

@article{
author = "Janković, Saša and Aleksić, Zoran and Milinković, Iva and Dimitrijević, B.",
year = "2010",
abstract = "The main objective of this study was to evaluate the clinical effectiveness of platelet-rich fibrin membrane used in combination with a coronally advanced flap (CAF) and to compare it with the use of an enamel matrix derivative (EMD) in combination with a coronally advanced flap in gingival recession treatment. 20 split-mouth cases of maxillary anterior teeth or bicuspids presenting with Miller Class I or II gingival recession were treated with a CAF combined with a platelet-rich fibrin membrane (PRF group) or with EMD (EMD group) placed under a CAF. The following parameters were measured at baseline and at 12 months post treatment: gingival recession (GR), apicocoronal width of the keratinized tissue (WKT), and probing depth (PD). Complete rot coverage in the PRF group was 65% (13 out of 20 recessions) and 60% in the EMD group (12 out of 20 recessions). GR was 4.10 ± 1.05 mm in the PRF group and 3.90 ± 1.00 mm in the EMD group at baseline, and 1.05 ± 0.45 mm in the PRF group and 1.15 ± 0.65 mm in the EMD group at 12 months. The difference observed between the tow groups at 12 months was statistically significant. Average root coverage was 70.5% in the EMD group and 72.1% in the PRF group. WKT was 1.30 ± 0.56 mm in the EMD group and 1.45 ± 0.86 mm in the PRF group at baseline, and 1.90 ± 0.81 mm in the EMD group and 1.62 ± 0.28 mm in the PRF group at 12 months. The difference observed between the two groups at 12 months was not statistically significant. Twelve-month changes in PD were not significantly different between the two groups. The pain intensity was statistically different between the two groups. The pain intensity was statistically different between groups for the first 5 days, favoring the PRF group. The present study did not succeed in demonstrating any clinical advantage of the use of PRF compared to EMD in the coverage of gingival recession with the CAF procedure. The EMD group showed a higher success rate in increasing WKT than did the PRF group.",
journal = "The European Journal of Esthetic Dentistry",
title = "The coronally advanced flap in combination with platelet-rich fibrin (PRF) and enamel matrix derivative in the treatment of gingival recession: a comparative study.",
volume = "5",
number = "3",
pages = "260-273",
url = "https://hdl.handle.net/21.15107/rcub_smile_1595"
}

Janković, S., Aleksić, Z., Milinković, I.,& Dimitrijević, B.. (2010). The coronally advanced flap in combination with platelet-rich fibrin (PRF) and enamel matrix derivative in the treatment of gingival recession: a comparative study.. in The European Journal of Esthetic Dentistry, 5(3), 260-273.
https://hdl.handle.net/21.15107/rcub_smile_1595

Janković S, Aleksić Z, Milinković I, Dimitrijević B. The coronally advanced flap in combination with platelet-rich fibrin (PRF) and enamel matrix derivative in the treatment of gingival recession: a comparative study.. in The European Journal of Esthetic Dentistry. 2010;5(3):260-273.
https://hdl.handle.net/21.15107/rcub_smile_1595 .

Janković, Saša, Aleksić, Zoran, Milinković, Iva, Dimitrijević, B., "The coronally advanced flap in combination with platelet-rich fibrin (PRF) and enamel matrix derivative in the treatment of gingival recession: a comparative study." in The European Journal of Esthetic Dentistry, 5, no. 3 (2010):260-273,
https://hdl.handle.net/21.15107/rcub_smile_1595 .

TY  - JOUR
AU  - Aleksić, Zoran
AU  - Janković, Saša
AU  - Dimitrijević, Božidar
AU  - Divnić-Resnik, Tihana
AU  - Milinković, Iva
AU  - Leković, Vojislav
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1558
AB  - Introduction. Fibrin, fibronectin, platelet derived growth factor, and transforming growth factors from platelet concetrate are crucial for tissue reparation and regeneration. Objective. This study was designed to evaluate clinical effectiveness of activated platelet-rich fibrin (PRF) membrane in treatment of gingival recession. Methods. 19 gingival recessions Miller class I or II were treated with a coronally advanced flap and the PRF membrane (PRF group). Following the elevation of the flap, bone and root surfaces were covered with the PRF membrane. After suturing, the PRF membrane was covered with a coronally advanced flap. In the same patients, 19 other gingival recessions were treated with CTG in combination with the coronally advanced flap (the CTG group). Clinical recordings were made of vertical recession depth (VRD), probing depth (PD), clinical attachment level (CAL) and keratinized tissue width (KTW) before and 12 months after mucogingival surgical treatment. Clinical evaluation of healing events was estimated with recordings of the healing index (HI). Recordings of HI were performed in the 1st, 2nd and 3rd week post-surgically. Results. Mean root coverage was significant in both groups (the PRF group 79.94% and the CTG group 88.56% %; p lt 0.01). The difference between the two tested groups was not statistically significant. Results of the keratinized tissue width showed significant increase (p lt 0.05) 12 months after the surgery in both, the PRF and CTG groups. Results of KTW showed statistical significance of recorded differences obtained in the two evaluated groups (p lt 0.05). There was no statistical significance in reduction of PD and CAL recorded in the PRF and CTG groups. The values of HI recorded in the 1st and 2nd week postoperatively were significantly enhanced in the PRF group (p lt 0.05). Conclusion. Results of this study confirm both procedures as effective with equivalence of clinical results in solving gingival recession problems. The utilization of the PRF resulted in a decreased postoperative discomfort and advanced tissue healing.
AB  - Uvod. Fibrin, fibronektin, faktor rasta poreklom iz trombocita i transformišući faktor rasta imaju presudnu ulogu u regeneraciji i reparaciji tkiva. Cilj rada. Ispitati i utvrditi značaj primene membrane od fibrina bogatog trombocitima (engl. plateletrich fibrin - PRF) u lečenju recesija gingive. Metode rada. Devetnaest obostranih gingivalnih recesija klase I ili II po Mileru lečeno je sa dva različita terapijska modaliteta. U eksperimentalnoj grupi recesija je, nakon odizanja mukoperiostnog režnja, preko izložene alveolarne kosti i korena zuba postavljena PRF membrana kao augmentacioni materijal, koja je zatim pokrivena koronarno pomerenim režnjem. U kontrolnoj grupi su izložena alveolarna kost i koren zuba prekriveni transplantatom vezivnog tkiva (TVT) uz koronarno pomereni režanj. Kod obe grupe recesija posmatrani su sledeći parametri: veličina recesije gingive, širina keratinizovane gingive, nivo pripojnog epitela i dubina sondiranja. Parametri su mereni neposredno pre hirurškog zahvata i 12 meseci kasnije. Zabeležen je i indeks zarastanja rane tokom prve tri nedelje posle operacije. Rezultati. Kod obe grupe recesija postignuto je značajno prekrivanje ogoljenog korena zuba (PRF membrana 79,94% i TVT 88,56%; p lt 0,01), dok između dve ispitivane grupe nije uočena statistički značajna razlika. Rezultati ispitivanja širine keratinizovane gingive su pokazali značajno povećanje u obe ispitivane grupe dvanaest meseci nakon hirurškog lečenja (p lt 0,05). Takođe je uočena statistički značajna razlika između posmatranih grupa (p lt 0,05) kod parametra širina keratinizovane gingive. Statističke značajnosti kada je reč o smanjenju nivoa pripojnog epitela i dubine sondiranja, kako u okviru grupa, tako i između obe ispitivane grupe (p>0,05), nije bilo. Merenjem indeksa zarastanja rane uočeni su značajno bolji rezultati u eksperimentalnoj grupi nakon prve i druge nedelje nego u kontrolnoj (p lt 0,05). Zaključak. Oba postupka pokazala su se adekvatnim u lečenju gingivalnih recesija. U kontrolnoj grupi bili su bolji rezultati u dobitku keratinizovanog tkiva, dok se eksperimentalna procedura pokazala jednostavnijom i komfornijom za samog bolesnika, uz značajno bolji postoperacioni tok.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The use of platelet-rich fibrin membrane in gingival recession treatment
T1  - Klinička primena fibrinske membrane u lečenju recesija gingive
VL  - 138
IS  - 1-2
SP  - 11
EP  - 18
DO  - 10.2298/SARH1002011A
ER  - 

@article{
author = "Aleksić, Zoran and Janković, Saša and Dimitrijević, Božidar and Divnić-Resnik, Tihana and Milinković, Iva and Leković, Vojislav",
year = "2010",
abstract = "Introduction. Fibrin, fibronectin, platelet derived growth factor, and transforming growth factors from platelet concetrate are crucial for tissue reparation and regeneration. Objective. This study was designed to evaluate clinical effectiveness of activated platelet-rich fibrin (PRF) membrane in treatment of gingival recession. Methods. 19 gingival recessions Miller class I or II were treated with a coronally advanced flap and the PRF membrane (PRF group). Following the elevation of the flap, bone and root surfaces were covered with the PRF membrane. After suturing, the PRF membrane was covered with a coronally advanced flap. In the same patients, 19 other gingival recessions were treated with CTG in combination with the coronally advanced flap (the CTG group). Clinical recordings were made of vertical recession depth (VRD), probing depth (PD), clinical attachment level (CAL) and keratinized tissue width (KTW) before and 12 months after mucogingival surgical treatment. Clinical evaluation of healing events was estimated with recordings of the healing index (HI). Recordings of HI were performed in the 1st, 2nd and 3rd week post-surgically. Results. Mean root coverage was significant in both groups (the PRF group 79.94% and the CTG group 88.56% %; p lt 0.01). The difference between the two tested groups was not statistically significant. Results of the keratinized tissue width showed significant increase (p lt 0.05) 12 months after the surgery in both, the PRF and CTG groups. Results of KTW showed statistical significance of recorded differences obtained in the two evaluated groups (p lt 0.05). There was no statistical significance in reduction of PD and CAL recorded in the PRF and CTG groups. The values of HI recorded in the 1st and 2nd week postoperatively were significantly enhanced in the PRF group (p lt 0.05). Conclusion. Results of this study confirm both procedures as effective with equivalence of clinical results in solving gingival recession problems. The utilization of the PRF resulted in a decreased postoperative discomfort and advanced tissue healing., Uvod. Fibrin, fibronektin, faktor rasta poreklom iz trombocita i transformišući faktor rasta imaju presudnu ulogu u regeneraciji i reparaciji tkiva. Cilj rada. Ispitati i utvrditi značaj primene membrane od fibrina bogatog trombocitima (engl. plateletrich fibrin - PRF) u lečenju recesija gingive. Metode rada. Devetnaest obostranih gingivalnih recesija klase I ili II po Mileru lečeno je sa dva različita terapijska modaliteta. U eksperimentalnoj grupi recesija je, nakon odizanja mukoperiostnog režnja, preko izložene alveolarne kosti i korena zuba postavljena PRF membrana kao augmentacioni materijal, koja je zatim pokrivena koronarno pomerenim režnjem. U kontrolnoj grupi su izložena alveolarna kost i koren zuba prekriveni transplantatom vezivnog tkiva (TVT) uz koronarno pomereni režanj. Kod obe grupe recesija posmatrani su sledeći parametri: veličina recesije gingive, širina keratinizovane gingive, nivo pripojnog epitela i dubina sondiranja. Parametri su mereni neposredno pre hirurškog zahvata i 12 meseci kasnije. Zabeležen je i indeks zarastanja rane tokom prve tri nedelje posle operacije. Rezultati. Kod obe grupe recesija postignuto je značajno prekrivanje ogoljenog korena zuba (PRF membrana 79,94% i TVT 88,56%; p lt 0,01), dok između dve ispitivane grupe nije uočena statistički značajna razlika. Rezultati ispitivanja širine keratinizovane gingive su pokazali značajno povećanje u obe ispitivane grupe dvanaest meseci nakon hirurškog lečenja (p lt 0,05). Takođe je uočena statistički značajna razlika između posmatranih grupa (p lt 0,05) kod parametra širina keratinizovane gingive. Statističke značajnosti kada je reč o smanjenju nivoa pripojnog epitela i dubine sondiranja, kako u okviru grupa, tako i između obe ispitivane grupe (p>0,05), nije bilo. Merenjem indeksa zarastanja rane uočeni su značajno bolji rezultati u eksperimentalnoj grupi nakon prve i druge nedelje nego u kontrolnoj (p lt 0,05). Zaključak. Oba postupka pokazala su se adekvatnim u lečenju gingivalnih recesija. U kontrolnoj grupi bili su bolji rezultati u dobitku keratinizovanog tkiva, dok se eksperimentalna procedura pokazala jednostavnijom i komfornijom za samog bolesnika, uz značajno bolji postoperacioni tok.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The use of platelet-rich fibrin membrane in gingival recession treatment, Klinička primena fibrinske membrane u lečenju recesija gingive",
volume = "138",
number = "1-2",
pages = "11-18",
doi = "10.2298/SARH1002011A"
}

Aleksić, Z., Janković, S., Dimitrijević, B., Divnić-Resnik, T., Milinković, I.,& Leković, V.. (2010). The use of platelet-rich fibrin membrane in gingival recession treatment. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 138(1-2), 11-18.
https://doi.org/10.2298/SARH1002011A

Aleksić Z, Janković S, Dimitrijević B, Divnić-Resnik T, Milinković I, Leković V. The use of platelet-rich fibrin membrane in gingival recession treatment. in Srpski arhiv za celokupno lekarstvo. 2010;138(1-2):11-18.
doi:10.2298/SARH1002011A .

Aleksić, Zoran, Janković, Saša, Dimitrijević, Božidar, Divnić-Resnik, Tihana, Milinković, Iva, Leković, Vojislav, "The use of platelet-rich fibrin membrane in gingival recession treatment" in Srpski arhiv za celokupno lekarstvo, 138, no. 1-2 (2010):11-18,
https://doi.org/10.2298/SARH1002011A . .

TY  - JOUR
AU  - Danilović, Vesna
AU  - Petrović, Vanja
AU  - Marković, Dejan
AU  - Aleksić, Zoran
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1451
AB  - Background/Aim. There are very few data about the effects of endogenous growth factors in vital pulp therapy, and still they are often controversial. The aim of the study was to evaluate the effects of platelet rich plasma (PRP) in conjugation with hydroxyapatite (HAP), as pulp capping materials, to root and periodontium formation. Methods. Eight young monkeys (Cercopithecus Aethiops) with permanent dentition and incomplete root formation were involved in this study. After pulpotomy, the pulp lesion was capped with calcium hydroxide (control), hydroxyapatite (experimental group I) or hydroxyapatite in conjugation with PRP (experimental group II). Six months later, the animals were sacrificed, the tissue was removed en block, and prepared for the histological analysis in a routine way. Results. The results of the histological analysis revealed that healing process was characterised by dentin bridge formation, maintained morphological and functional integrity of dental pulp and complete formation of dental root and surrounding periodontium. The inflammatory reaction was scored as mild to moderate, in almost all the samples in all groups, suggesting the biocompatibility of the used materials. Conclusion. Materials used in this study are convenient as capping agents, contributing maintaining the integrity of the pulp tissue and facilitating root and periodontium formation. According to histological data it could be suggested that hydroxyapatite in conjugation with endogenous growth factors, represents superior alternative to other materials used in this study.
AB  - Uvod/Cilj. Podaci o primeni endogenih faktora rasta u terapiji vitalne pulpe zuba sa nezavršenim rastom korena su veoma oskudni i često kontraverzni. Cilj ovog rada bio je da se ispita uticaj plazme bogate trombocitima (PRP) u kombinaciji sa hidroksiapatitom (HAP), kao materijala za direktno prekrivanje pulpe, na završetak rasta korena i formiranje okolnog parodoncijuma. Metode. Istraživanje je obavljeno na osam mladih majmuna Cercopithecus Aethiops. Sve životinje imale su zube stalne denticije, sa nezavršenim rastom korena. Nakon trepanacije pulpnog prostora, pulpa je uklonjena do nivoa gleđnocementnog spoja, a lezija u pulpi prekrivena je kalcijum hidroksidom (kontrolna grupa), hidroksiapatitom (eksperimentna grupa I) i hidroksiapatitom u kombinaciji sa autogenim PRP faktorom (eksperimentna grupa II). Šest meseci nakon amputacije pulpe, životinje su žrtvovane, a tkivo za histološku analizu uzeto je u obliku blok sekcije i pripremljeno za mikroskopsku analizu. Rezultati. Zarastanje rane u pulpno-dentinskom kompleksu u obe eksperimentne i u kontrolnoj grupi bilo je karakterisano stvaranjem dentinskog mostića procesom reparativne dentinogeneze, očuvanjem morfološkog i funkcijskog integriteta pulpe, kao i završetkom rasta korena i stvaranjem okolnog parodoncijuma. U većini uzoraka obe grupe, zapaljenska reakcija ocenjena je kao blaga do umerena, što govori u prilog biokompatibilnosti primenjenih materijala. Zaključak. Svi primenjeni materijali pogodni su za direktno prekrivanje pulpe, doprinose očuvanju njenog morfološkog i funkcionalnog integriteta i omogućavaju završetak rasta korena i formiranje okolnog parodoncijuma. Ipak, povoljniji rezultati dobijeni su u grupi koja je tretirana HAP/PRP, pa se može reći da HAP obogaćen endogenim faktorima rasta predstavlja superiorniju alternativu u odnosu na ostale materijale primenjene u ovoj studiji.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals
T1  - Histološka evaluacija efekata plazme bogate trombocitima i hidroksiapatita u procesu apeksogeneze - studija na eksperimentnim životinjama
VL  - 65
IS  - 2
SP  - 128
EP  - 134
DO  - 10.2298/VSP0802128D
ER  - 

@article{
author = "Danilović, Vesna and Petrović, Vanja and Marković, Dejan and Aleksić, Zoran",
year = "2008",
abstract = "Background/Aim. There are very few data about the effects of endogenous growth factors in vital pulp therapy, and still they are often controversial. The aim of the study was to evaluate the effects of platelet rich plasma (PRP) in conjugation with hydroxyapatite (HAP), as pulp capping materials, to root and periodontium formation. Methods. Eight young monkeys (Cercopithecus Aethiops) with permanent dentition and incomplete root formation were involved in this study. After pulpotomy, the pulp lesion was capped with calcium hydroxide (control), hydroxyapatite (experimental group I) or hydroxyapatite in conjugation with PRP (experimental group II). Six months later, the animals were sacrificed, the tissue was removed en block, and prepared for the histological analysis in a routine way. Results. The results of the histological analysis revealed that healing process was characterised by dentin bridge formation, maintained morphological and functional integrity of dental pulp and complete formation of dental root and surrounding periodontium. The inflammatory reaction was scored as mild to moderate, in almost all the samples in all groups, suggesting the biocompatibility of the used materials. Conclusion. Materials used in this study are convenient as capping agents, contributing maintaining the integrity of the pulp tissue and facilitating root and periodontium formation. According to histological data it could be suggested that hydroxyapatite in conjugation with endogenous growth factors, represents superior alternative to other materials used in this study., Uvod/Cilj. Podaci o primeni endogenih faktora rasta u terapiji vitalne pulpe zuba sa nezavršenim rastom korena su veoma oskudni i često kontraverzni. Cilj ovog rada bio je da se ispita uticaj plazme bogate trombocitima (PRP) u kombinaciji sa hidroksiapatitom (HAP), kao materijala za direktno prekrivanje pulpe, na završetak rasta korena i formiranje okolnog parodoncijuma. Metode. Istraživanje je obavljeno na osam mladih majmuna Cercopithecus Aethiops. Sve životinje imale su zube stalne denticije, sa nezavršenim rastom korena. Nakon trepanacije pulpnog prostora, pulpa je uklonjena do nivoa gleđnocementnog spoja, a lezija u pulpi prekrivena je kalcijum hidroksidom (kontrolna grupa), hidroksiapatitom (eksperimentna grupa I) i hidroksiapatitom u kombinaciji sa autogenim PRP faktorom (eksperimentna grupa II). Šest meseci nakon amputacije pulpe, životinje su žrtvovane, a tkivo za histološku analizu uzeto je u obliku blok sekcije i pripremljeno za mikroskopsku analizu. Rezultati. Zarastanje rane u pulpno-dentinskom kompleksu u obe eksperimentne i u kontrolnoj grupi bilo je karakterisano stvaranjem dentinskog mostića procesom reparativne dentinogeneze, očuvanjem morfološkog i funkcijskog integriteta pulpe, kao i završetkom rasta korena i stvaranjem okolnog parodoncijuma. U većini uzoraka obe grupe, zapaljenska reakcija ocenjena je kao blaga do umerena, što govori u prilog biokompatibilnosti primenjenih materijala. Zaključak. Svi primenjeni materijali pogodni su za direktno prekrivanje pulpe, doprinose očuvanju njenog morfološkog i funkcionalnog integriteta i omogućavaju završetak rasta korena i formiranje okolnog parodoncijuma. Ipak, povoljniji rezultati dobijeni su u grupi koja je tretirana HAP/PRP, pa se može reći da HAP obogaćen endogenim faktorima rasta predstavlja superiorniju alternativu u odnosu na ostale materijale primenjene u ovoj studiji.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals, Histološka evaluacija efekata plazme bogate trombocitima i hidroksiapatita u procesu apeksogeneze - studija na eksperimentnim životinjama",
volume = "65",
number = "2",
pages = "128-134",
doi = "10.2298/VSP0802128D"
}

Danilović, V., Petrović, V., Marković, D.,& Aleksić, Z.. (2008). Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 65(2), 128-134.
https://doi.org/10.2298/VSP0802128D

Danilović V, Petrović V, Marković D, Aleksić Z. Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals. in Vojnosanitetski pregled. 2008;65(2):128-134.
doi:10.2298/VSP0802128D .

Danilović, Vesna, Petrović, Vanja, Marković, Dejan, Aleksić, Zoran, "Histological evaluation of platelet rich plasma and hydroxiapatite in apexogenesis: Study on experimental animals" in Vojnosanitetski pregled, 65, no. 2 (2008):128-134,
https://doi.org/10.2298/VSP0802128D . .

TY  - JOUR
AU  - Aleksić, Zoran
AU  - Janković, Saša
AU  - Dimitrijević, Božidar
AU  - Pucar, Ana
AU  - Lazić, Vojkan
AU  - Leković, Vojislav
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1437
AB  - Introduction Root coverage supported with complete regeneration of lost periodontal tissues represents the ultimate goal of gingival recession treatment. Objective This study was designed to evaluate clinical effectiveness of platelet rich plasma gel (PRP) with connective tissue graft (CTG) in the treatment of gingival recession. METHOD 15 gingival recessions Miller class I or II were treated with CTG and PRP (group PRP). Connective tissue graft was harvested from the premolar region using trap door technique. After elevation of the flap, the regional bone and root surface were smeared with activated PRP gel. CTG was also irrigated with PRP gel before placement over the exposed root surface and local bone. Fixed CTG was covered with a coronally advanced flap. The same number of gingival recessions were treated with CTG in combination with the coronally advanced flap with no PRP gel (group TVT). Clinical recordings included recession depth (RD), probing depth (PD), clinical attachment level (CAL) and keratinized tissue width (KT) before and 1 year after mucogingival surgical treatment. Results Mean value of RD was significantly decreased from 4.93±0.86 mm to 0.60±0.37 (p lt 0.01) with CTG and PRP and from 4.76±0.74 mm to 0.63±0.29 mm (p lt 0.01) in CTG group. This difference was not statistically significant. Results of the keratinized tissue width showed significant increase from 0.88± 0.30 mm presurgery to 3.78±0.49 mm (p lt 0.01) six months after treatment in PRP group and from 0.90±0.34 mm to 3.15±0.41 in TVT group (p lt 0.01). This difference was statistically significant (p>0.05). No statistically significant differences were observed between treatment groups in CAL and PD. Conclusion Clinical results validate both procedures as effective and highly predictable surgical techniques in solving gingival recession problem. Histological evaluation may confirm advantage of PRP use related to regeneration of periodontal tissues.
AB  - Uvod. Recesija gingive je jedan od najsloženijih problema savremene stomatologije. Iznalaženje novih terapijskih metoda za rešavanje ovog problema je značajan segment istraživanja u parodontologiji. Cilj rada. Cilj rada je bio da se procene klinički efekti primene plazme bogate trombocitima (PBT) u kombinaciji sa transplantatom vezivnog tkiva (TVT) u lečenju recesije gingive. Metod rada. Istraživanje je obuhvatilo 15 bolesnika s obostranim recesijama gingive klase II i III po Mileru (Miller). Metodološki koncept se zasnivao na metodu podeljenih usta. U lečenju 15 recesija primenjen je TVT u kombinaciji sa koronarno pozicioniranim režnjem uz primenu aktiviranog koncentrata trombocita (PBT grupa). Isti broj recesija na suprotnoj strani vilice zbrinjavan je autotransplantatom vezivnog tkiva i periosta u kombinaciji sa koronarno pozicioniranim režnjem (TVT grupa). Za procenu stanja parodoncijuma i efikasnosti primenjenih hirurških postupaka korišćeni su sledeći klinički parametri: vertikalna dubina recesije (VDR), nivo pripojnog epitela i širina keratinizovane gingive. Nivo oralne higijene je utvrđivan plak-indeksom po Silnes- Lou (Silness-Löu), a stanje gingive gingivnim indeksom po Lou-Silnesu (Löu-Silness). Rezultati. Na osnovu analize srednje vrednost za dubinu recesije (VDR), ustanovljeno je statistički značajno smanjenje vrednosti ovog parametra šest meseci posle tretmana u PBT grupi (sa 4,93±0,86 mm na 0,60±0,37 mm; p lt 0,01). U TVT grupi, u kojoj je vrednost VDR pre lečenja bila 4,76±0,74 mm, posle šest meseci dobijena je vrednost od 0,63±0,29 mm (p lt 0,01). U PBT grupi je posle opservacionog perioda zabeleženo proširenje zone keratinizovanog tkiva za 2,90 mm, dok je u istom periodu vrednost ovog parametra u TVT grupi bila 2,25 mm. Poređenjem prosečne promene vrednosti kliničkih parametara u okviru obe eksperimentalne grupe, samo je kod promene širine keratinizovanog tkiva zabeležena statistička značajnost (p lt 0,05). Zaključak. Rezultati ove kliničke studije ukazuju na izuzetnu efikasnost oba primenjena postupka u lečenju recesije gingive.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Clinical impact of platelet rich plasma in treatment of gingival recessions
T1  - Primena plazme bogate trombocitima u rekonstruktivnoj mukogingivnoj hirurgiji
VL  - 136
IS  - 3-4
SP  - 95
EP  - 103
DO  - 10.2298/SARH0804095A
ER  - 

@article{
author = "Aleksić, Zoran and Janković, Saša and Dimitrijević, Božidar and Pucar, Ana and Lazić, Vojkan and Leković, Vojislav",
year = "2008",
abstract = "Introduction Root coverage supported with complete regeneration of lost periodontal tissues represents the ultimate goal of gingival recession treatment. Objective This study was designed to evaluate clinical effectiveness of platelet rich plasma gel (PRP) with connective tissue graft (CTG) in the treatment of gingival recession. METHOD 15 gingival recessions Miller class I or II were treated with CTG and PRP (group PRP). Connective tissue graft was harvested from the premolar region using trap door technique. After elevation of the flap, the regional bone and root surface were smeared with activated PRP gel. CTG was also irrigated with PRP gel before placement over the exposed root surface and local bone. Fixed CTG was covered with a coronally advanced flap. The same number of gingival recessions were treated with CTG in combination with the coronally advanced flap with no PRP gel (group TVT). Clinical recordings included recession depth (RD), probing depth (PD), clinical attachment level (CAL) and keratinized tissue width (KT) before and 1 year after mucogingival surgical treatment. Results Mean value of RD was significantly decreased from 4.93±0.86 mm to 0.60±0.37 (p lt 0.01) with CTG and PRP and from 4.76±0.74 mm to 0.63±0.29 mm (p lt 0.01) in CTG group. This difference was not statistically significant. Results of the keratinized tissue width showed significant increase from 0.88± 0.30 mm presurgery to 3.78±0.49 mm (p lt 0.01) six months after treatment in PRP group and from 0.90±0.34 mm to 3.15±0.41 in TVT group (p lt 0.01). This difference was statistically significant (p>0.05). No statistically significant differences were observed between treatment groups in CAL and PD. Conclusion Clinical results validate both procedures as effective and highly predictable surgical techniques in solving gingival recession problem. Histological evaluation may confirm advantage of PRP use related to regeneration of periodontal tissues., Uvod. Recesija gingive je jedan od najsloženijih problema savremene stomatologije. Iznalaženje novih terapijskih metoda za rešavanje ovog problema je značajan segment istraživanja u parodontologiji. Cilj rada. Cilj rada je bio da se procene klinički efekti primene plazme bogate trombocitima (PBT) u kombinaciji sa transplantatom vezivnog tkiva (TVT) u lečenju recesije gingive. Metod rada. Istraživanje je obuhvatilo 15 bolesnika s obostranim recesijama gingive klase II i III po Mileru (Miller). Metodološki koncept se zasnivao na metodu podeljenih usta. U lečenju 15 recesija primenjen je TVT u kombinaciji sa koronarno pozicioniranim režnjem uz primenu aktiviranog koncentrata trombocita (PBT grupa). Isti broj recesija na suprotnoj strani vilice zbrinjavan je autotransplantatom vezivnog tkiva i periosta u kombinaciji sa koronarno pozicioniranim režnjem (TVT grupa). Za procenu stanja parodoncijuma i efikasnosti primenjenih hirurških postupaka korišćeni su sledeći klinički parametri: vertikalna dubina recesije (VDR), nivo pripojnog epitela i širina keratinizovane gingive. Nivo oralne higijene je utvrđivan plak-indeksom po Silnes- Lou (Silness-Löu), a stanje gingive gingivnim indeksom po Lou-Silnesu (Löu-Silness). Rezultati. Na osnovu analize srednje vrednost za dubinu recesije (VDR), ustanovljeno je statistički značajno smanjenje vrednosti ovog parametra šest meseci posle tretmana u PBT grupi (sa 4,93±0,86 mm na 0,60±0,37 mm; p lt 0,01). U TVT grupi, u kojoj je vrednost VDR pre lečenja bila 4,76±0,74 mm, posle šest meseci dobijena je vrednost od 0,63±0,29 mm (p lt 0,01). U PBT grupi je posle opservacionog perioda zabeleženo proširenje zone keratinizovanog tkiva za 2,90 mm, dok je u istom periodu vrednost ovog parametra u TVT grupi bila 2,25 mm. Poređenjem prosečne promene vrednosti kliničkih parametara u okviru obe eksperimentalne grupe, samo je kod promene širine keratinizovanog tkiva zabeležena statistička značajnost (p lt 0,05). Zaključak. Rezultati ove kliničke studije ukazuju na izuzetnu efikasnost oba primenjena postupka u lečenju recesije gingive.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Clinical impact of platelet rich plasma in treatment of gingival recessions, Primena plazme bogate trombocitima u rekonstruktivnoj mukogingivnoj hirurgiji",
volume = "136",
number = "3-4",
pages = "95-103",
doi = "10.2298/SARH0804095A"
}

Aleksić, Z., Janković, S., Dimitrijević, B., Pucar, A., Lazić, V.,& Leković, V.. (2008). Clinical impact of platelet rich plasma in treatment of gingival recessions. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 136(3-4), 95-103.
https://doi.org/10.2298/SARH0804095A

Aleksić Z, Janković S, Dimitrijević B, Pucar A, Lazić V, Leković V. Clinical impact of platelet rich plasma in treatment of gingival recessions. in Srpski arhiv za celokupno lekarstvo. 2008;136(3-4):95-103.
doi:10.2298/SARH0804095A .

Aleksić, Zoran, Janković, Saša, Dimitrijević, Božidar, Pucar, Ana, Lazić, Vojkan, Leković, Vojislav, "Clinical impact of platelet rich plasma in treatment of gingival recessions" in Srpski arhiv za celokupno lekarstvo, 136, no. 3-4 (2008):95-103,
https://doi.org/10.2298/SARH0804095A . .