TY  - JOUR
AU  - Ćetković, Dejan
AU  - Milić, Marija
AU  - Biočanin, Vladimir
AU  - Brajić, Ivana
AU  - Ćalasan, Dejan
AU  - Radović, Katarina
AU  - Živković, Rade
AU  - Brković, Božidar
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2448
AB  - Bacground/Aim. The efficient dental anesthesia, which is related to the clinically adequate depth, duration and the width of anesthetic field, is an important prerequisite for successful dental treatment. The aim of this study was to investigate and compare the pulpal anesthesia and cardiovascular parameters after the anterior middle superior alveolar (AMSA) nerve block with 4% articaine with epinephrine administered by conventional cartridge-syringe and computer-controlled local anesthetic delivery system (CCLADS). Methods. This controlled double-blind cross-over randomized clinical study included 38 healthy volunteers. Efficacy of pulpal anesthesia after the AMSA nerve block was evaluated by measuring a success rate, onset and duration of pulpal anesthesia, using an electrical pulp tester. The parameters of cardiovascular function (systolic and diastolic blood pressure, heart rate) were monitored noninvasively. Results. Successful pulpal anesthesia of all tested teeth was obtained in 57.9% participants with CCLADS and in 44.7% participants with conventional syringe. The onset time was not significantly different between two investigated groups. The pulpal anesthesia duration was not significantly different neither within nor between investigated groups. The systolic and diastolic blood pressures were significantly decreased in both investigated groups, in comparison with the baseline values. Heart rate significantly decreased within CCLADS from 10th to 30th minute when compared to baseline. Conclusion. The efficacy of pulpal anesthesia and safety of cardiovascular profile of 0.6 mL of articaine with epinephrine (1:100.000) delivered with CCLADS were improved in comparison to the conventional syringe delivery. Significant changes of cardiovascular function were not observed.
AB  - Uvod/Cilj. Efikasna zubna anestezija u pogledu klinički adekvatne dubine, trajanja i širine anestetičkog polja je važan preduslov za uspešno zubno lečenje. Cilj rada bio je ispitivanje i upoređivanje parametra anestezije zubne pulpe i kardiovaskularnih parametra posle gornje prednje i srednje alveolarne (AMSA) sprovodne anestezije postignute 4% artikainom sa epinefrinom, primenom standardne karpulbrizgalice i kompjuterski kontrolisanog sistema za primenu anestetičkog rastvora (CCLADS). Metode. U ovom randomizovanom, prospektivnom, kontrolisanom, dvostruko slepom ukrštenom kliničkom istraživanju učestvovalo je 38 ispitanika. Kvalitet anestezije zubne pulpe posle AMSA anestezije praćen je na osnovu uspešnosti, latentnog perioda i trajanja anestezije zubne pulpe, primenom električnog pulp-testera. Parametri kardiovaskularne funkcije (sistolni i dijastolni krvni pritisak, srčana frekvencija) praćeni su neinvazivno, primenom aparata za monitoring. Rezultati. Uspešna anestezija zubne pulpe svih ispitivanih zuba bila je prisutna kod 57,9% ispitanika posle kod CCLADS i kod 44,7% ispitanika posle primene standardne karpul-brizgalice. Latentni period i trajanje anestezije zubne pulpe nisu se značajno razlikovali između ispitivanih grupa. Sistolni i dijastolni pritisak bili su značajno sniženi u praćenim vremenskim intervalima u odnosu na početne vrednosti. Srčana frekvencija je bila značajno snižena kod CCLADS grupe od 10 do 30 minuta u odnosu na početne vrednosti. Zaključak. Kontrolisanom kompjuterizovanom primenom (CCLADS) 0,6 mL 4% artikaina sa epinefrinom (1:100,000) za AMSA sprovodnu anesteziju, postignut je bolji kvalitet anestezije zubne pulpe u odnosu na primenu artikaina sa epinefrinom standardnom karpul brizgalicom. Nisu uočene bitne promene funkcija kardiovaskularnog sistema.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study
T1  - Efikasnost i sigurnost 4% artikaina sa epinefrinom za gornji prednji i srednji alveolarni nervni blok primenom kompjuterski kontrolisanog sistema i standardnog pristupa za primenu anestetičkog rastvora - prospektivna, randomizovana, kontrolisana, dvosturko slepa, ukrštena klinička studija
VL  - 76
IS  - 10
SP  - 1045
EP  - 1053
DO  - 10.2298/VSP170511013C
ER  - 

@article{
author = "Ćetković, Dejan and Milić, Marija and Biočanin, Vladimir and Brajić, Ivana and Ćalasan, Dejan and Radović, Katarina and Živković, Rade and Brković, Božidar",
year = "2019",
abstract = "Bacground/Aim. The efficient dental anesthesia, which is related to the clinically adequate depth, duration and the width of anesthetic field, is an important prerequisite for successful dental treatment. The aim of this study was to investigate and compare the pulpal anesthesia and cardiovascular parameters after the anterior middle superior alveolar (AMSA) nerve block with 4% articaine with epinephrine administered by conventional cartridge-syringe and computer-controlled local anesthetic delivery system (CCLADS). Methods. This controlled double-blind cross-over randomized clinical study included 38 healthy volunteers. Efficacy of pulpal anesthesia after the AMSA nerve block was evaluated by measuring a success rate, onset and duration of pulpal anesthesia, using an electrical pulp tester. The parameters of cardiovascular function (systolic and diastolic blood pressure, heart rate) were monitored noninvasively. Results. Successful pulpal anesthesia of all tested teeth was obtained in 57.9% participants with CCLADS and in 44.7% participants with conventional syringe. The onset time was not significantly different between two investigated groups. The pulpal anesthesia duration was not significantly different neither within nor between investigated groups. The systolic and diastolic blood pressures were significantly decreased in both investigated groups, in comparison with the baseline values. Heart rate significantly decreased within CCLADS from 10th to 30th minute when compared to baseline. Conclusion. The efficacy of pulpal anesthesia and safety of cardiovascular profile of 0.6 mL of articaine with epinephrine (1:100.000) delivered with CCLADS were improved in comparison to the conventional syringe delivery. Significant changes of cardiovascular function were not observed., Uvod/Cilj. Efikasna zubna anestezija u pogledu klinički adekvatne dubine, trajanja i širine anestetičkog polja je važan preduslov za uspešno zubno lečenje. Cilj rada bio je ispitivanje i upoređivanje parametra anestezije zubne pulpe i kardiovaskularnih parametra posle gornje prednje i srednje alveolarne (AMSA) sprovodne anestezije postignute 4% artikainom sa epinefrinom, primenom standardne karpulbrizgalice i kompjuterski kontrolisanog sistema za primenu anestetičkog rastvora (CCLADS). Metode. U ovom randomizovanom, prospektivnom, kontrolisanom, dvostruko slepom ukrštenom kliničkom istraživanju učestvovalo je 38 ispitanika. Kvalitet anestezije zubne pulpe posle AMSA anestezije praćen je na osnovu uspešnosti, latentnog perioda i trajanja anestezije zubne pulpe, primenom električnog pulp-testera. Parametri kardiovaskularne funkcije (sistolni i dijastolni krvni pritisak, srčana frekvencija) praćeni su neinvazivno, primenom aparata za monitoring. Rezultati. Uspešna anestezija zubne pulpe svih ispitivanih zuba bila je prisutna kod 57,9% ispitanika posle kod CCLADS i kod 44,7% ispitanika posle primene standardne karpul-brizgalice. Latentni period i trajanje anestezije zubne pulpe nisu se značajno razlikovali između ispitivanih grupa. Sistolni i dijastolni pritisak bili su značajno sniženi u praćenim vremenskim intervalima u odnosu na početne vrednosti. Srčana frekvencija je bila značajno snižena kod CCLADS grupe od 10 do 30 minuta u odnosu na početne vrednosti. Zaključak. Kontrolisanom kompjuterizovanom primenom (CCLADS) 0,6 mL 4% artikaina sa epinefrinom (1:100,000) za AMSA sprovodnu anesteziju, postignut je bolji kvalitet anestezije zubne pulpe u odnosu na primenu artikaina sa epinefrinom standardnom karpul brizgalicom. Nisu uočene bitne promene funkcija kardiovaskularnog sistema.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study, Efikasnost i sigurnost 4% artikaina sa epinefrinom za gornji prednji i srednji alveolarni nervni blok primenom kompjuterski kontrolisanog sistema i standardnog pristupa za primenu anestetičkog rastvora - prospektivna, randomizovana, kontrolisana, dvosturko slepa, ukrštena klinička studija",
volume = "76",
number = "10",
pages = "1045-1053",
doi = "10.2298/VSP170511013C"
}

Ćetković, D., Milić, M., Biočanin, V., Brajić, I., Ćalasan, D., Radović, K., Živković, R.,& Brković, B.. (2019). Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(10), 1045-1053.
https://doi.org/10.2298/VSP170511013C

Ćetković D, Milić M, Biočanin V, Brajić I, Ćalasan D, Radović K, Živković R, Brković B. Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study. in Vojnosanitetski pregled. 2019;76(10):1045-1053.
doi:10.2298/VSP170511013C .

Ćetković, Dejan, Milić, Marija, Biočanin, Vladimir, Brajić, Ivana, Ćalasan, Dejan, Radović, Katarina, Živković, Rade, Brković, Božidar, "Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study" in Vojnosanitetski pregled, 76, no. 10 (2019):1045-1053,
https://doi.org/10.2298/VSP170511013C . .

TY  - JOUR
AU  - Ilić, Dragan
AU  - Antonijević, Đorđe
AU  - Biočanin, Vladimir
AU  - Čolović, Božana
AU  - Danilović, Vesna
AU  - Komlev, Vladimir S.
AU  - Teterina, Anastasia
AU  - Jokanović, Vukoman
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2411
AB  - Dental cement materials have been developed with the aim to replace hard dental tissues. The first material used for pulp capping, root canal obturation, bifurcation perforation and apexification is calcium hydroxide (in 1920). A half century later, glass-ionomer cements began to suppress it as dentine substitutes. Finally, in the 1990s, calcium silicate (CS) material appeared in the dental research community as the most promising dentine substitute capable to adequately meet all clinical requirements. The aim of this paper is to present an overview of literature related to studies about CS materials taking into account their physical, chemical and biological properties and clinical applications. This review aims to discuss beneficial and adverse characteristics of CSs concerning interactions to the hard dentine and soft pulp/periodontal tissues. This review article deals with the literature data about currently commercially available CS concerning laboratory and clinical findings. 109 scientific articles were analyzed of which 62 references reported in vitro and 26 in vivo investigations while 21 references comprised reports, reviews and books dealing with both, in vitro and in vivo investigations. Although further data collection is necessary, CSs are promising materials that represent a gold standard for numerous dental clinical procedures.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska Industrija
T1  - Physico-chemical and biological properties of dental calcium silicate cements - literature review
VL  - 73
IS  - 5
SP  - 281
EP  - 294
DO  - 10.2298/HEMIND190614027I
ER  - 

@article{
author = "Ilić, Dragan and Antonijević, Đorđe and Biočanin, Vladimir and Čolović, Božana and Danilović, Vesna and Komlev, Vladimir S. and Teterina, Anastasia and Jokanović, Vukoman",
year = "2019",
abstract = "Dental cement materials have been developed with the aim to replace hard dental tissues. The first material used for pulp capping, root canal obturation, bifurcation perforation and apexification is calcium hydroxide (in 1920). A half century later, glass-ionomer cements began to suppress it as dentine substitutes. Finally, in the 1990s, calcium silicate (CS) material appeared in the dental research community as the most promising dentine substitute capable to adequately meet all clinical requirements. The aim of this paper is to present an overview of literature related to studies about CS materials taking into account their physical, chemical and biological properties and clinical applications. This review aims to discuss beneficial and adverse characteristics of CSs concerning interactions to the hard dentine and soft pulp/periodontal tissues. This review article deals with the literature data about currently commercially available CS concerning laboratory and clinical findings. 109 scientific articles were analyzed of which 62 references reported in vitro and 26 in vivo investigations while 21 references comprised reports, reviews and books dealing with both, in vitro and in vivo investigations. Although further data collection is necessary, CSs are promising materials that represent a gold standard for numerous dental clinical procedures.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska Industrija",
title = "Physico-chemical and biological properties of dental calcium silicate cements - literature review",
volume = "73",
number = "5",
pages = "281-294",
doi = "10.2298/HEMIND190614027I"
}

Ilić, D., Antonijević, Đ., Biočanin, V., Čolović, B., Danilović, V., Komlev, V. S., Teterina, A.,& Jokanović, V.. (2019). Physico-chemical and biological properties of dental calcium silicate cements - literature review. in Hemijska Industrija
Savez hemijskih inženjera, Beograd., 73(5), 281-294.
https://doi.org/10.2298/HEMIND190614027I

Ilić D, Antonijević Đ, Biočanin V, Čolović B, Danilović V, Komlev VS, Teterina A, Jokanović V. Physico-chemical and biological properties of dental calcium silicate cements - literature review. in Hemijska Industrija. 2019;73(5):281-294.
doi:10.2298/HEMIND190614027I .

Ilić, Dragan, Antonijević, Đorđe, Biočanin, Vladimir, Čolović, Božana, Danilović, Vesna, Komlev, Vladimir S., Teterina, Anastasia, Jokanović, Vukoman, "Physico-chemical and biological properties of dental calcium silicate cements - literature review" in Hemijska Industrija, 73, no. 5 (2019):281-294,
https://doi.org/10.2298/HEMIND190614027I . .

TY  - JOUR
AU  - Biočanin, Vladimir
AU  - Antonijević, Đorđe
AU  - Poštić, Srđan
AU  - Ilić, Dragan
AU  - Vuković, Zorica
AU  - Milić, Marija
AU  - Fan, Yifang
AU  - Li, Zhiyu
AU  - Brković, Božidar
AU  - Durić, Marija
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2289
AB  - Introduction: The outcome of periapical surgery has been directly improved with the introduction of novel material formulations. The aim of the study was to compare the retrograde obturation quality of the following materials: calcium silicate (Biodentine; Septodont, Saint-Maur-des-Fosses, France), mineral trioxide aggregate (MTA+; Cerkamed Company, Stalowa Wola, Poland), and glass ionomer cement (Fuji IX; GC Corporation, Tokyo, Japan). Methods: Materials' wettability was calculated concerning the contact angles of the cements measured using a glycerol drop. Cements' porosity was determined using mercury intrusion porosimetry and micro computed tomographic (mu CT) imaging. Extracted upper human incisors were retrofilled, and mu CT analysis was applied to calculate the volume of the gap between the retrograde filling material and root canal dentin. Experiments were performed before and after soaking the materials in simulated body fluid (SBF). Results: No statistically significant differences were found among the contact angles of the studied materials after being soaked in SBF. The material with the lowest nanoporosity (Fuji IX: 2.99% and 4.17% before and after SBF, respectively) showed the highest values of microporosity (4.2% and 3.1% before and after SBF, respectively). Biodentine had the lowest value of microporosity (1.2% and 0.8% before and after SBF, respectively) and the lowest value of microgap to the root canal wall ([10 +/- 30] x 10(-3) mm(3)). Conclusions: Biodentine and MTA possess certain advantages over Fuji IX for hermetic obturation of retrograde root canals. Biodentine shows a tendency toward the lowest marginal gap at the cement-to-dentin interface.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - Marginal Gaps between 2 Calcium Silicate and Glass lonomer Cements and Apical Root Dentin
VL  - 44
IS  - 5
SP  - 816
EP  - 821
DO  - 10.1016/j.joen.2017.09.022
ER  - 

@article{
author = "Biočanin, Vladimir and Antonijević, Đorđe and Poštić, Srđan and Ilić, Dragan and Vuković, Zorica and Milić, Marija and Fan, Yifang and Li, Zhiyu and Brković, Božidar and Durić, Marija",
year = "2018",
abstract = "Introduction: The outcome of periapical surgery has been directly improved with the introduction of novel material formulations. The aim of the study was to compare the retrograde obturation quality of the following materials: calcium silicate (Biodentine; Septodont, Saint-Maur-des-Fosses, France), mineral trioxide aggregate (MTA+; Cerkamed Company, Stalowa Wola, Poland), and glass ionomer cement (Fuji IX; GC Corporation, Tokyo, Japan). Methods: Materials' wettability was calculated concerning the contact angles of the cements measured using a glycerol drop. Cements' porosity was determined using mercury intrusion porosimetry and micro computed tomographic (mu CT) imaging. Extracted upper human incisors were retrofilled, and mu CT analysis was applied to calculate the volume of the gap between the retrograde filling material and root canal dentin. Experiments were performed before and after soaking the materials in simulated body fluid (SBF). Results: No statistically significant differences were found among the contact angles of the studied materials after being soaked in SBF. The material with the lowest nanoporosity (Fuji IX: 2.99% and 4.17% before and after SBF, respectively) showed the highest values of microporosity (4.2% and 3.1% before and after SBF, respectively). Biodentine had the lowest value of microporosity (1.2% and 0.8% before and after SBF, respectively) and the lowest value of microgap to the root canal wall ([10 +/- 30] x 10(-3) mm(3)). Conclusions: Biodentine and MTA possess certain advantages over Fuji IX for hermetic obturation of retrograde root canals. Biodentine shows a tendency toward the lowest marginal gap at the cement-to-dentin interface.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "Marginal Gaps between 2 Calcium Silicate and Glass lonomer Cements and Apical Root Dentin",
volume = "44",
number = "5",
pages = "816-821",
doi = "10.1016/j.joen.2017.09.022"
}

Biočanin, V., Antonijević, Đ., Poštić, S., Ilić, D., Vuković, Z., Milić, M., Fan, Y., Li, Z., Brković, B.,& Durić, M.. (2018). Marginal Gaps between 2 Calcium Silicate and Glass lonomer Cements and Apical Root Dentin. in Journal of Endodontics
Elsevier Science Inc, New York., 44(5), 816-821.
https://doi.org/10.1016/j.joen.2017.09.022

Biočanin V, Antonijević Đ, Poštić S, Ilić D, Vuković Z, Milić M, Fan Y, Li Z, Brković B, Durić M. Marginal Gaps between 2 Calcium Silicate and Glass lonomer Cements and Apical Root Dentin. in Journal of Endodontics. 2018;44(5):816-821.
doi:10.1016/j.joen.2017.09.022 .

Biočanin, Vladimir, Antonijević, Đorđe, Poštić, Srđan, Ilić, Dragan, Vuković, Zorica, Milić, Marija, Fan, Yifang, Li, Zhiyu, Brković, Božidar, Durić, Marija, "Marginal Gaps between 2 Calcium Silicate and Glass lonomer Cements and Apical Root Dentin" in Journal of Endodontics, 44, no. 5 (2018):816-821,
https://doi.org/10.1016/j.joen.2017.09.022 . .

TY  - JOUR
AU  - Biočanin, Vladimir
AU  - Milić, Marija
AU  - Vučetić, Milan
AU  - Baćević, Miljana
AU  - Vasović, Dina
AU  - Živadinović, Milka
AU  - Ćetković, Dejan
AU  - Ćalasan, Dejan
AU  - Brković, Božidar
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2073
AB  - Introduction. The material used for root-end filling has to be biocompatible with adjacent periapical tissue and to stimulate its regenerative processes. Tricalcium silicate cement (TSC), as a new dental material, shows good sealing properties with dentin, high compression strengths and better marginal adaptation than commonly used root-end filling materials. Although optimal postoperative healing of periapical tissues is mainly influenced by characteristics of end-root material used, it could sometimes be affected by the influence of systemic diseases, such as diabetes mellitus (DM). Case report. We presented apical healing of the upper central incisor, retrofilled with TSC, in a diabetic patient (type 2 DM) with peripheral neuropathy. Standard root-end resection of upper central incisor was accompanied by retropreparation using ultrasonic retrotips to the depth of 3 mm and retrofilling with TSC. Postoperatively, the surgical wound healed uneventfully. However, the patient reported undefined dull pain in the operated area that could possibly be attributed to undiagnosed intraoral diabetic peripheral neuropathy, what was evaluated clinically. Conclusion. Although TSC presents a suitable material for apical root-end filling in the treatment of chronic periradicular lesions a possible presence of systemic diseases, like type 2 DM, has to be considered in the treatment outcome estimation.
AB  - Uvod. Materijal koji se koristi za retrogradnu opturaciju kanala korena trebalo bi da bude biokompatibilan sa okolnim periapeksnim tkivom i da stimuliše procese njegove regeneracije. Trikalcijum silikatni cement (TSC), kao novi dentalni materijal, pokazuje dobro zaptivanje, visoku kompresivnu snagu i bolju ivičnu adaptaciju u odnosu na standardno korišćene materijale za retroopturaciju. Iako postoperativno zarastanje periapikalnog tkiva najviše zavisi od karakteristika materijala za retroopturaciju, ponekad na uspeh zarastanja može uticati i prisustvo neke sistemske bolesti kao što je dijabetes melitus (DM). Prikaz bolesnika. Prikazali smo apikalno zarastanje u predelu gornjeg centralnog sekutića, nakon retroopturacije sa TSC, kod bolesnika sa DM tipa 2 i prisutnom perifernom neuropatijom. Standardna resekcija korena gornjeg centralnog sekutića bila je urađena retropreparacijom ultrazvučnim nastavcima do dubine od 3 mm i retrogradnom opturacijom sa TSC. Zarastanje postoperativne regije bilo je u fiziološkim granicama. Bolesnik se, međutim, žalio na nedefinisan, tup bol u predelu operisane regije koji je verovatno bio povezan sa nedijagnostikovanom intraoralnom dijabetičnom perifernom neuropatijom, što je potvrđeno kliničkim nalazom. Zaključak. Iako TSC predstavlja pogodan materijal za retrogradnu opturaciju kanala korena zuba u lečenju hroničnih periradikularnih lezija, u proceni ishoda lečenja treba imati u vidu i moguće prisustvo perifernih manfestacija sistemskih bolesti kao što je DM tipa 2.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report
T1  - Punjenje kanala korena cementom na bazi trikalcijum-silikata kod bolesnika sa dijabetesom melitusom
VL  - 73
IS  - 12
SP  - 1173
EP  - 1177
DO  - 10.2298/VSP150606137B
ER  - 

@article{
author = "Biočanin, Vladimir and Milić, Marija and Vučetić, Milan and Baćević, Miljana and Vasović, Dina and Živadinović, Milka and Ćetković, Dejan and Ćalasan, Dejan and Brković, Božidar",
year = "2016",
abstract = "Introduction. The material used for root-end filling has to be biocompatible with adjacent periapical tissue and to stimulate its regenerative processes. Tricalcium silicate cement (TSC), as a new dental material, shows good sealing properties with dentin, high compression strengths and better marginal adaptation than commonly used root-end filling materials. Although optimal postoperative healing of periapical tissues is mainly influenced by characteristics of end-root material used, it could sometimes be affected by the influence of systemic diseases, such as diabetes mellitus (DM). Case report. We presented apical healing of the upper central incisor, retrofilled with TSC, in a diabetic patient (type 2 DM) with peripheral neuropathy. Standard root-end resection of upper central incisor was accompanied by retropreparation using ultrasonic retrotips to the depth of 3 mm and retrofilling with TSC. Postoperatively, the surgical wound healed uneventfully. However, the patient reported undefined dull pain in the operated area that could possibly be attributed to undiagnosed intraoral diabetic peripheral neuropathy, what was evaluated clinically. Conclusion. Although TSC presents a suitable material for apical root-end filling in the treatment of chronic periradicular lesions a possible presence of systemic diseases, like type 2 DM, has to be considered in the treatment outcome estimation., Uvod. Materijal koji se koristi za retrogradnu opturaciju kanala korena trebalo bi da bude biokompatibilan sa okolnim periapeksnim tkivom i da stimuliše procese njegove regeneracije. Trikalcijum silikatni cement (TSC), kao novi dentalni materijal, pokazuje dobro zaptivanje, visoku kompresivnu snagu i bolju ivičnu adaptaciju u odnosu na standardno korišćene materijale za retroopturaciju. Iako postoperativno zarastanje periapikalnog tkiva najviše zavisi od karakteristika materijala za retroopturaciju, ponekad na uspeh zarastanja može uticati i prisustvo neke sistemske bolesti kao što je dijabetes melitus (DM). Prikaz bolesnika. Prikazali smo apikalno zarastanje u predelu gornjeg centralnog sekutića, nakon retroopturacije sa TSC, kod bolesnika sa DM tipa 2 i prisutnom perifernom neuropatijom. Standardna resekcija korena gornjeg centralnog sekutića bila je urađena retropreparacijom ultrazvučnim nastavcima do dubine od 3 mm i retrogradnom opturacijom sa TSC. Zarastanje postoperativne regije bilo je u fiziološkim granicama. Bolesnik se, međutim, žalio na nedefinisan, tup bol u predelu operisane regije koji je verovatno bio povezan sa nedijagnostikovanom intraoralnom dijabetičnom perifernom neuropatijom, što je potvrđeno kliničkim nalazom. Zaključak. Iako TSC predstavlja pogodan materijal za retrogradnu opturaciju kanala korena zuba u lečenju hroničnih periradikularnih lezija, u proceni ishoda lečenja treba imati u vidu i moguće prisustvo perifernih manfestacija sistemskih bolesti kao što je DM tipa 2.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report, Punjenje kanala korena cementom na bazi trikalcijum-silikata kod bolesnika sa dijabetesom melitusom",
volume = "73",
number = "12",
pages = "1173-1177",
doi = "10.2298/VSP150606137B"
}

Biočanin, V., Milić, M., Vučetić, M., Baćević, M., Vasović, D., Živadinović, M., Ćetković, D., Ćalasan, D.,& Brković, B.. (2016). Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(12), 1173-1177.
https://doi.org/10.2298/VSP150606137B

Biočanin V, Milić M, Vučetić M, Baćević M, Vasović D, Živadinović M, Ćetković D, Ćalasan D, Brković B. Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report. in Vojnosanitetski pregled. 2016;73(12):1173-1177.
doi:10.2298/VSP150606137B .

Biočanin, Vladimir, Milić, Marija, Vučetić, Milan, Baćević, Miljana, Vasović, Dina, Živadinović, Milka, Ćetković, Dejan, Ćalasan, Dejan, Brković, Božidar, "Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report" in Vojnosanitetski pregled, 73, no. 12 (2016):1173-1177,
https://doi.org/10.2298/VSP150606137B . .

TY  - JOUR
AU  - Biočanin, Vladimir
AU  - Brajković, Denis
AU  - Stevanović, Momir
AU  - Tatić, Zoran
AU  - Andrić, Miroslav
AU  - Brković, Božidar
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2029
AB  - Introduction. Therapeutic approach to jaw cysts may depend on their dimensions and localization. Enucleation of cystic lesion is not always preferable in the first act, especially if large cysts are in close proximity to important anatomical structures. The aim of this paper was to present the outcome of the treatment protocol comprising preoperative decompression and subsequent enucleation of a large maxillary cyst. Case re-port. A 21-year-old male patient with large asymptomatic radicular cyst in the right maxillary sinus was presented to our clinic. Conebeam computed tomography (CBCT) showed a large cyst, which perforated the right anterior maxillary wall by 1.5 cm, and was in the intimate contact with the orbital floor. Surgical treatment of the cystic lesion comprised: preoperative decompression with biopsy in the first act and enucleation, performed under general anesthesia, 6 months after the observation period. Conclusion. Decompression with subsequent enucleation proved to be effective treatment of large radicular cyst in maxillary sinus with low-morbidity.
AB  - Uvod. Terapijski pristup cistama vilice može zavisiti od njihovih dimenzija i lokalizacije. Enukleacija cistične lezije često nije pogodna u prvom aktu ako se velika cista nalazi u blizini važnih anatomskih struktura. Cilj ovog rada bio je da se prikaže ishod lečenja velike ciste u maksilarnom sinusu koji je podrazumevao preoperativnu dekompresiju i odloženu enukleaciju. Prikaz bolesnika. Prikazan je bolesnik, star 21 godinu, sa velikom, asimptomatskom, radikularnom cistom u maksilarnom sinusu. Radiografska dijagnostika pomoću cone-beam kompjuterizovane tomografije (CBCT), pokazala je prisustvo velike cistične lezije koja je probila prednji maksilarni zid (1,5 cm) i bila u bliskom kontaktu sa podom orbite. Hirurški tretman cistične lezije uključio je preoperativnu dekompresiju i biopsiju u prvom aktu i enukleaciju u opštoj anesteziji nakon 6 meseci. Zaključak. De-kompresija i odložena enukleacija pokazale su se efikasnim terapijskim pristupom kod lečenje velike radikularne ciste maksilarnog sinusa uz mali morbiditet.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Decompression as an effective primary approach to large radicular cyst in the maxillary sinus: A case report
T1  - Dekompresija kao delotvorni primarni pristup radikularnoj cisti u maksilarnom sinusu
VL  - 72
IS  - 7
SP  - 634
EP  - 638
DO  - 10.2298/vsp140317043B
ER  - 

@article{
author = "Biočanin, Vladimir and Brajković, Denis and Stevanović, Momir and Tatić, Zoran and Andrić, Miroslav and Brković, Božidar",
year = "2015",
abstract = "Introduction. Therapeutic approach to jaw cysts may depend on their dimensions and localization. Enucleation of cystic lesion is not always preferable in the first act, especially if large cysts are in close proximity to important anatomical structures. The aim of this paper was to present the outcome of the treatment protocol comprising preoperative decompression and subsequent enucleation of a large maxillary cyst. Case re-port. A 21-year-old male patient with large asymptomatic radicular cyst in the right maxillary sinus was presented to our clinic. Conebeam computed tomography (CBCT) showed a large cyst, which perforated the right anterior maxillary wall by 1.5 cm, and was in the intimate contact with the orbital floor. Surgical treatment of the cystic lesion comprised: preoperative decompression with biopsy in the first act and enucleation, performed under general anesthesia, 6 months after the observation period. Conclusion. Decompression with subsequent enucleation proved to be effective treatment of large radicular cyst in maxillary sinus with low-morbidity., Uvod. Terapijski pristup cistama vilice može zavisiti od njihovih dimenzija i lokalizacije. Enukleacija cistične lezije često nije pogodna u prvom aktu ako se velika cista nalazi u blizini važnih anatomskih struktura. Cilj ovog rada bio je da se prikaže ishod lečenja velike ciste u maksilarnom sinusu koji je podrazumevao preoperativnu dekompresiju i odloženu enukleaciju. Prikaz bolesnika. Prikazan je bolesnik, star 21 godinu, sa velikom, asimptomatskom, radikularnom cistom u maksilarnom sinusu. Radiografska dijagnostika pomoću cone-beam kompjuterizovane tomografije (CBCT), pokazala je prisustvo velike cistične lezije koja je probila prednji maksilarni zid (1,5 cm) i bila u bliskom kontaktu sa podom orbite. Hirurški tretman cistične lezije uključio je preoperativnu dekompresiju i biopsiju u prvom aktu i enukleaciju u opštoj anesteziji nakon 6 meseci. Zaključak. De-kompresija i odložena enukleacija pokazale su se efikasnim terapijskim pristupom kod lečenje velike radikularne ciste maksilarnog sinusa uz mali morbiditet.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Decompression as an effective primary approach to large radicular cyst in the maxillary sinus: A case report, Dekompresija kao delotvorni primarni pristup radikularnoj cisti u maksilarnom sinusu",
volume = "72",
number = "7",
pages = "634-638",
doi = "10.2298/vsp140317043B"
}

Biočanin, V., Brajković, D., Stevanović, M., Tatić, Z., Andrić, M.,& Brković, B.. (2015). Decompression as an effective primary approach to large radicular cyst in the maxillary sinus: A case report. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(7), 634-638.
https://doi.org/10.2298/vsp140317043B

Biočanin V, Brajković D, Stevanović M, Tatić Z, Andrić M, Brković B. Decompression as an effective primary approach to large radicular cyst in the maxillary sinus: A case report. in Vojnosanitetski pregled. 2015;72(7):634-638.
doi:10.2298/vsp140317043B .

Biočanin, Vladimir, Brajković, Denis, Stevanović, Momir, Tatić, Zoran, Andrić, Miroslav, Brković, Božidar, "Decompression as an effective primary approach to large radicular cyst in the maxillary sinus: A case report" in Vojnosanitetski pregled, 72, no. 7 (2015):634-638,
https://doi.org/10.2298/vsp140317043B . .

TY  - JOUR
AU  - Brajković, Denis
AU  - Brković, Božidar
AU  - Milić, Marija
AU  - Biočanin, Vladimir
AU  - Kršljak, Elena
AU  - Stojić, Dragica
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1857
AB  - The main purpose of this prospective, double-blind, randomized study was to evaluate anaesthetic parameters, postoperative analgesia and vasoactive properties of levobupivacaine and bupivacaine for lower third molar surgery. Sixty patients (ASA I) were scheduled for lower third molar surgery under inferior alveolar nerve block, lingual nerve block and buccal nerve block (mandibular nerve blocks) obtained with 3 ml of 0.5 % levobupivacaine and 3 ml of 0.5 % bupivacaine. Success rate, onset and duration of three nerve bocks were evaluated by electrical pulp testing, pinprick testing and signs of soft tissue anaesthesia (patient-reported numbness). Intensity of intraoperative anaesthesia and postoperative analgesia were measured with visual analogue scale (VAS) and numeric rating scale (NRS). The time of first postoperative pain reported and analgesic consumption were also recorded. The laser Doppler flowmetry was used for the measurement of the first premolar pulpal blood flow. There were no differences between levobupivacaine and bupivacaine regarding the success rate, onset and duration of mandibular nerve blocks as well as intensity of postoperative analgesia and analgesic consumption. Intensity of intraoperative anaesthesia and duration of postoperative analgesia were significantly higher in the levobupivacaine than in the bupivacaine group. Both anaesthetics showed similar biphasic vasoactive effect. Levobupivacaine 0.5 % achieved superiority over bupivacaine 0.5 % in the intensity of intraoperative anaesthesia and duration of postoperative analgesia for lower third molar surgery under the mandibular nerve blocks. It seems that the plain levobupivacaine (0.5 %) could be an effective alternative to plain bupivacaine (0.5 %) in those dental procedures which require profound bone and soft tissue anaesthesia.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects
VL  - 18
IS  - 5
SP  - 1481
EP  - 1488
DO  - 10.1007/s00784-013-1114-0
ER  - 

@article{
author = "Brajković, Denis and Brković, Božidar and Milić, Marija and Biočanin, Vladimir and Kršljak, Elena and Stojić, Dragica",
year = "2014",
abstract = "The main purpose of this prospective, double-blind, randomized study was to evaluate anaesthetic parameters, postoperative analgesia and vasoactive properties of levobupivacaine and bupivacaine for lower third molar surgery. Sixty patients (ASA I) were scheduled for lower third molar surgery under inferior alveolar nerve block, lingual nerve block and buccal nerve block (mandibular nerve blocks) obtained with 3 ml of 0.5 % levobupivacaine and 3 ml of 0.5 % bupivacaine. Success rate, onset and duration of three nerve bocks were evaluated by electrical pulp testing, pinprick testing and signs of soft tissue anaesthesia (patient-reported numbness). Intensity of intraoperative anaesthesia and postoperative analgesia were measured with visual analogue scale (VAS) and numeric rating scale (NRS). The time of first postoperative pain reported and analgesic consumption were also recorded. The laser Doppler flowmetry was used for the measurement of the first premolar pulpal blood flow. There were no differences between levobupivacaine and bupivacaine regarding the success rate, onset and duration of mandibular nerve blocks as well as intensity of postoperative analgesia and analgesic consumption. Intensity of intraoperative anaesthesia and duration of postoperative analgesia were significantly higher in the levobupivacaine than in the bupivacaine group. Both anaesthetics showed similar biphasic vasoactive effect. Levobupivacaine 0.5 % achieved superiority over bupivacaine 0.5 % in the intensity of intraoperative anaesthesia and duration of postoperative analgesia for lower third molar surgery under the mandibular nerve blocks. It seems that the plain levobupivacaine (0.5 %) could be an effective alternative to plain bupivacaine (0.5 %) in those dental procedures which require profound bone and soft tissue anaesthesia.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects",
volume = "18",
number = "5",
pages = "1481-1488",
doi = "10.1007/s00784-013-1114-0"
}

Brajković, D., Brković, B., Milić, M., Biočanin, V., Kršljak, E.,& Stojić, D.. (2014). Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 18(5), 1481-1488.
https://doi.org/10.1007/s00784-013-1114-0

Brajković D, Brković B, Milić M, Biočanin V, Kršljak E, Stojić D. Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects. in Clinical Oral Investigations. 2014;18(5):1481-1488.
doi:10.1007/s00784-013-1114-0 .

Brajković, Denis, Brković, Božidar, Milić, Marija, Biočanin, Vladimir, Kršljak, Elena, Stojić, Dragica, "Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects" in Clinical Oral Investigations, 18, no. 5 (2014):1481-1488,
https://doi.org/10.1007/s00784-013-1114-0 . .

TY  - JOUR
AU  - Biočanin, Vladimir
AU  - Brković, Božidar
AU  - Miličić, Biljana
AU  - Stojić, Dragica
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1841
AB  - The main purpose of this study was to evaluate the dose-dependent anesthetic efficacy of the intraseptal anesthesia (ISA) and periodontal ligament anesthesia (PLA) obtained with different volumes of 4 % articaine and 1:100,000 epinephrine (Ar + Ep) in human mandibular premolars, using a computer-controlled local anesthetic delivery system (CCLADS). The safety profile of Ar + Ep was also studied by investigating the stability of cardiovascular parameters. One hundred and eighty randomly selected healthy volunteers (ASA I) entered the single-blinded study to receive 16 mg + 4 mu g, 24 mg + 6 mu g, and 32 mg + 8 mu g of Ar + Ep, obtained with different volumes (0.4, 0.6, and 0.8 ml, respectively), for the ISA and PLA. Success rate, onset, and duration of profound pulpal anesthesia were evaluated by the electrical pulp tester, while the width of the anesthetic field and duration of soft tissue anesthesia were recorded using the pinprick testing. A monitor was used for the measurement of cardiovascular parameters. A dose-dependent duration of pulpal and soft tissue anesthesia was obtained only by the ISA. Success rate, duration of both pulpal and soft tissue anesthesia, and its width were significantly better in the ISA compared with the PLA. No significant cardiovascular changes were seen in both groups. It can be suggested that 0.6 and 0.8 ml of 4 % Ar + 1:100,000 Ep, delivered by CCLADS, offer high success rate and effective clinical parameters of ISA as a primary anesthesia. It seems that dental procedures requiring profound pulpal, bone, and soft tissue anesthesia could be effectively and safely obtained by mentioned anesthetic protocol.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine plus epinephrine delivery: a dose-finding study
VL  - 17
IS  - 2
SP  - 525
EP  - 533
DO  - 10.1007/s00784-012-0724-2
ER  - 

@article{
author = "Biočanin, Vladimir and Brković, Božidar and Miličić, Biljana and Stojić, Dragica",
year = "2013",
abstract = "The main purpose of this study was to evaluate the dose-dependent anesthetic efficacy of the intraseptal anesthesia (ISA) and periodontal ligament anesthesia (PLA) obtained with different volumes of 4 % articaine and 1:100,000 epinephrine (Ar + Ep) in human mandibular premolars, using a computer-controlled local anesthetic delivery system (CCLADS). The safety profile of Ar + Ep was also studied by investigating the stability of cardiovascular parameters. One hundred and eighty randomly selected healthy volunteers (ASA I) entered the single-blinded study to receive 16 mg + 4 mu g, 24 mg + 6 mu g, and 32 mg + 8 mu g of Ar + Ep, obtained with different volumes (0.4, 0.6, and 0.8 ml, respectively), for the ISA and PLA. Success rate, onset, and duration of profound pulpal anesthesia were evaluated by the electrical pulp tester, while the width of the anesthetic field and duration of soft tissue anesthesia were recorded using the pinprick testing. A monitor was used for the measurement of cardiovascular parameters. A dose-dependent duration of pulpal and soft tissue anesthesia was obtained only by the ISA. Success rate, duration of both pulpal and soft tissue anesthesia, and its width were significantly better in the ISA compared with the PLA. No significant cardiovascular changes were seen in both groups. It can be suggested that 0.6 and 0.8 ml of 4 % Ar + 1:100,000 Ep, delivered by CCLADS, offer high success rate and effective clinical parameters of ISA as a primary anesthesia. It seems that dental procedures requiring profound pulpal, bone, and soft tissue anesthesia could be effectively and safely obtained by mentioned anesthetic protocol.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine plus epinephrine delivery: a dose-finding study",
volume = "17",
number = "2",
pages = "525-533",
doi = "10.1007/s00784-012-0724-2"
}

Biočanin, V., Brković, B., Miličić, B.,& Stojić, D.. (2013). Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine plus epinephrine delivery: a dose-finding study. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 17(2), 525-533.
https://doi.org/10.1007/s00784-012-0724-2

Biočanin V, Brković B, Miličić B, Stojić D. Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine plus epinephrine delivery: a dose-finding study. in Clinical Oral Investigations. 2013;17(2):525-533.
doi:10.1007/s00784-012-0724-2 .

Biočanin, Vladimir, Brković, Božidar, Miličić, Biljana, Stojić, Dragica, "Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine plus epinephrine delivery: a dose-finding study" in Clinical Oral Investigations, 17, no. 2 (2013):525-533,
https://doi.org/10.1007/s00784-012-0724-2 . .

TY  - THES
AU  - Biočanin, Vladimir
PY  - 2012
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=599
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:6762/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024184206
UR  - http://nardus.mpn.gov.rs/123456789/2687
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/964
AB  - In dentistry, local anesthesia is usually obtained by standard, local intraoral anesthesia, such as block and infiltration. In some cases, complete painless procedure could not be obtained with previously mentioned anesthesia. Therefore, using additional anaesthesia, such as intraseptal (ISA) and periodontal ligament (IPA), adequate pain control is achieved. It has been shown that these two additional anesthesia, which belong to intraosseal anesthesia, could be used as primary anesthesia. Special problem for intraoral anesthesia, and also for other types of anesthesia, are patients with diabetes mellitus type 2 (DM type 2), because they have microvascular damage of blood vessels which feed nerves and diminish nerve impulse conduction. Aim: The aim of this doctoral dissertation was evaluation of dose dependency among 0,4, 0,6 and 0,8 ml of 4% articaine with 1:100,000 epinephrine (Ar + Ep) for ISA and IPA, achieved by computer - contolled local anesthetic delivery system (CCLADS), and finding effective and safe dose in healthy individuals and patients with DM type 2. Material and method: This clinical study included 204 healthy individuals (ASA I) and 80 patients with DM type 2 (ASA II and ASA III). Healthy individuals were divided in two big groups: ISA (104 individuals) and IPA (100 individuals). These two groups were devided into three subgroups of 30 anesthetized teeth, depending on the used dose of Ar + Ep, in upper and lower jaw. Selected teeth, upper lateral incisor and lower first premolar, were indicated for extraction. Used with Computer – controlled local anesthetic delivery system (CCLADS, Anaeject®, Septodont , France), in healthy individuals, doses of Ar + Ep were: 0,4 ml (16 mg + 4 μg), 0,6 ml (24 mg + 6 μg) i 0,8 ml (32 mg + 8 μg). Patients with DM type 2 were also devided in two groups: ISA (38 patients with 60 tested teeth in both jaws – 30 teeth each jaw), IPA (42 patients with 60 tested teeth – 30 teeth each jaw). Within these groups (DM type 2 patients), the dose of Ar + Ep which had been shown clinically effective and safe in healthy individuals, was used. Success rate, onset and duration of pulpal anesthesia were recorded with the electric pulp tester (pulp test) (Vitality Scanner Model 2006®, Sybron Endo, USA). The width of anesthetic field and soft tissue anesthesia duration were recorded with pinprick test. Cardiovascular (KV) parameters: systolic, diastolic, mean arterial pressure and heart rate, were measured by digital monitor (Wrist Blood Pressure Monitor, Model R3 Intellisense, Prizma, Kragujevac) and monitoring aparatus (Datex-Engstrom AS/3, Helsinki, Finland), before anesthesia, during anesthesia, such as 5, 10 15, and 30 minutes after anesthesia
AB  - Lokalna anestezija u stomatologiji se najčešće postiže standardnim, lokalnim intraoralnim anestezijama kao što su sprovodna i infiltrativna. U izvesnom broju slučajeva, pomenutim anestezijama se ne može obezbediti potpuna bezbolnost. Iz tog razloga, primenom dopunske anestezije, kao što je intraseptalna anestezija (ISA) i intraperiodontalna anestezija (IPA), postiže se adekvatna bezbolnost. Pokazano je da se ove vrste dopunskih anestezija, koje pripadaju intraosealnim anestezijama, mogu koristiti i kao samostalne anestezije. Poseban problem za primenu intraoralnih anestezija, kao i drugih vrsta anestezija, predstavljaju pacijenti sa dijabetes melitusom (DM), zbog postojanja mikrovaskularnih oštećenja krvnih sudova koji ishranjuju nerve i poremećaja u sprovođenju nervnih impulsa. Cilj: Cilj ove doktorske disertacije bio je da se ispitivanjem dozne zavisnosti 0,4, 0,6 i 0,8 ml 4% artikaina sa epinefrinom (1:100,000) (Ar +Ep) odredi efikasna i bezbedna doza ovog anestetika za ISA i IPA primenom kompjuterski kontrolisanog oslobađanja lokalnog anestetika (CCLADS), kako kod zdravih pacijenata, tako i kod pacijenata DM tip 2. Materijal i metod: U ovoj kliničkoj studiji učestvovalo je 204 zdrava ispitanika (ASA I) i 80 pacijenata sa DM tip 2 (ASA II i III). Zdravi ispitanici su bili podeljeni u 2 velike grupe: ISA (104 ispitanika) i IPA (100 ispitanika). Svaka od ove dve grupe bila je podeljena na po tri podgrupe po 30 anesteziranih zuba, u zavisnosti od primenjene količine Ar + Ep, kako u gornjoj, tako i u donjoj vilici. Ispitivani zubi su bili gornji lateralni sekutić i donji prvi premolar, koji su bili indikovani za ekstrakciju. Primenjene pomoću sistema za kompjuterski kontrolisano oslobađanje lokalnog anestetika (Computer-Controlled Local Anaesthetic Delivery System - CCLADS, Anaeject®, Septodont, Francuska), kod zdravih ispitanika, doze Ar + Ep su iznosile: 0,4 ml (16 mg + 4 μg), 0,6 ml (24 mg + 6 μg) i 0,8 ml (32 mg + 8 μg). Pacijenti sa DM tip 2 su bili podeljeni takođe u 2 grupe: ISA (38 pacijenata sa ukupno 60 ispitivanih zuba u obe vilice - 30 ispitivanih zuba u svakoj vilici), i IPA (42 pacijenta sa ukupno 60 ispitivanih zuba u obe vilice - po 30 ispitivanih zuba u svakoj vilici). U okviru ovih grupa primenjena je doza Ar + Ep koja se pokazala klinički efikasnom i bezbednom kod zdravih ispitanika. Uspešnost, latentni period i trajanje anestezije pulpe praćeni su električnim testom stimulacije zubne pulpe (pulp test) (Vitality Scanner Model 2006®, Sybron Endo, SAD)...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Comparative analysis of intraperiodontal and intraseptal anaesthesia quality in healthy individuals and patients with diabetes mellitus type 2
T1  - Komparativna analiza kvaliteta intraperiodontalne i intraseptalne anestezije izazvane artikainom sa epinefrinom kod zdravih i pacijenata sa dijabetes melitusom tip 2
UR  - https://hdl.handle.net/21.15107/rcub_nardus_2687
ER  - 

@phdthesis{
author = "Biočanin, Vladimir",
year = "2012",
abstract = "In dentistry, local anesthesia is usually obtained by standard, local intraoral anesthesia, such as block and infiltration. In some cases, complete painless procedure could not be obtained with previously mentioned anesthesia. Therefore, using additional anaesthesia, such as intraseptal (ISA) and periodontal ligament (IPA), adequate pain control is achieved. It has been shown that these two additional anesthesia, which belong to intraosseal anesthesia, could be used as primary anesthesia. Special problem for intraoral anesthesia, and also for other types of anesthesia, are patients with diabetes mellitus type 2 (DM type 2), because they have microvascular damage of blood vessels which feed nerves and diminish nerve impulse conduction. Aim: The aim of this doctoral dissertation was evaluation of dose dependency among 0,4, 0,6 and 0,8 ml of 4% articaine with 1:100,000 epinephrine (Ar + Ep) for ISA and IPA, achieved by computer - contolled local anesthetic delivery system (CCLADS), and finding effective and safe dose in healthy individuals and patients with DM type 2. Material and method: This clinical study included 204 healthy individuals (ASA I) and 80 patients with DM type 2 (ASA II and ASA III). Healthy individuals were divided in two big groups: ISA (104 individuals) and IPA (100 individuals). These two groups were devided into three subgroups of 30 anesthetized teeth, depending on the used dose of Ar + Ep, in upper and lower jaw. Selected teeth, upper lateral incisor and lower first premolar, were indicated for extraction. Used with Computer – controlled local anesthetic delivery system (CCLADS, Anaeject®, Septodont , France), in healthy individuals, doses of Ar + Ep were: 0,4 ml (16 mg + 4 μg), 0,6 ml (24 mg + 6 μg) i 0,8 ml (32 mg + 8 μg). Patients with DM type 2 were also devided in two groups: ISA (38 patients with 60 tested teeth in both jaws – 30 teeth each jaw), IPA (42 patients with 60 tested teeth – 30 teeth each jaw). Within these groups (DM type 2 patients), the dose of Ar + Ep which had been shown clinically effective and safe in healthy individuals, was used. Success rate, onset and duration of pulpal anesthesia were recorded with the electric pulp tester (pulp test) (Vitality Scanner Model 2006®, Sybron Endo, USA). The width of anesthetic field and soft tissue anesthesia duration were recorded with pinprick test. Cardiovascular (KV) parameters: systolic, diastolic, mean arterial pressure and heart rate, were measured by digital monitor (Wrist Blood Pressure Monitor, Model R3 Intellisense, Prizma, Kragujevac) and monitoring aparatus (Datex-Engstrom AS/3, Helsinki, Finland), before anesthesia, during anesthesia, such as 5, 10 15, and 30 minutes after anesthesia, Lokalna anestezija u stomatologiji se najčešće postiže standardnim, lokalnim intraoralnim anestezijama kao što su sprovodna i infiltrativna. U izvesnom broju slučajeva, pomenutim anestezijama se ne može obezbediti potpuna bezbolnost. Iz tog razloga, primenom dopunske anestezije, kao što je intraseptalna anestezija (ISA) i intraperiodontalna anestezija (IPA), postiže se adekvatna bezbolnost. Pokazano je da se ove vrste dopunskih anestezija, koje pripadaju intraosealnim anestezijama, mogu koristiti i kao samostalne anestezije. Poseban problem za primenu intraoralnih anestezija, kao i drugih vrsta anestezija, predstavljaju pacijenti sa dijabetes melitusom (DM), zbog postojanja mikrovaskularnih oštećenja krvnih sudova koji ishranjuju nerve i poremećaja u sprovođenju nervnih impulsa. Cilj: Cilj ove doktorske disertacije bio je da se ispitivanjem dozne zavisnosti 0,4, 0,6 i 0,8 ml 4% artikaina sa epinefrinom (1:100,000) (Ar +Ep) odredi efikasna i bezbedna doza ovog anestetika za ISA i IPA primenom kompjuterski kontrolisanog oslobađanja lokalnog anestetika (CCLADS), kako kod zdravih pacijenata, tako i kod pacijenata DM tip 2. Materijal i metod: U ovoj kliničkoj studiji učestvovalo je 204 zdrava ispitanika (ASA I) i 80 pacijenata sa DM tip 2 (ASA II i III). Zdravi ispitanici su bili podeljeni u 2 velike grupe: ISA (104 ispitanika) i IPA (100 ispitanika). Svaka od ove dve grupe bila je podeljena na po tri podgrupe po 30 anesteziranih zuba, u zavisnosti od primenjene količine Ar + Ep, kako u gornjoj, tako i u donjoj vilici. Ispitivani zubi su bili gornji lateralni sekutić i donji prvi premolar, koji su bili indikovani za ekstrakciju. Primenjene pomoću sistema za kompjuterski kontrolisano oslobađanje lokalnog anestetika (Computer-Controlled Local Anaesthetic Delivery System - CCLADS, Anaeject®, Septodont, Francuska), kod zdravih ispitanika, doze Ar + Ep su iznosile: 0,4 ml (16 mg + 4 μg), 0,6 ml (24 mg + 6 μg) i 0,8 ml (32 mg + 8 μg). Pacijenti sa DM tip 2 su bili podeljeni takođe u 2 grupe: ISA (38 pacijenata sa ukupno 60 ispitivanih zuba u obe vilice - 30 ispitivanih zuba u svakoj vilici), i IPA (42 pacijenta sa ukupno 60 ispitivanih zuba u obe vilice - po 30 ispitivanih zuba u svakoj vilici). U okviru ovih grupa primenjena je doza Ar + Ep koja se pokazala klinički efikasnom i bezbednom kod zdravih ispitanika. Uspešnost, latentni period i trajanje anestezije pulpe praćeni su električnim testom stimulacije zubne pulpe (pulp test) (Vitality Scanner Model 2006®, Sybron Endo, SAD)...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Comparative analysis of intraperiodontal and intraseptal anaesthesia quality in healthy individuals and patients with diabetes mellitus type 2, Komparativna analiza kvaliteta intraperiodontalne i intraseptalne anestezije izazvane artikainom sa epinefrinom kod zdravih i pacijenata sa dijabetes melitusom tip 2",
url = "https://hdl.handle.net/21.15107/rcub_nardus_2687"
}

Biočanin, V.. (2012). Comparative analysis of intraperiodontal and intraseptal anaesthesia quality in healthy individuals and patients with diabetes mellitus type 2. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_2687

Biočanin V. Comparative analysis of intraperiodontal and intraseptal anaesthesia quality in healthy individuals and patients with diabetes mellitus type 2. 2012;.
https://hdl.handle.net/21.15107/rcub_nardus_2687 .

Biočanin, Vladimir, "Comparative analysis of intraperiodontal and intraseptal anaesthesia quality in healthy individuals and patients with diabetes mellitus type 2" (2012),
https://hdl.handle.net/21.15107/rcub_nardus_2687 .

TY  - JOUR
AU  - Biočanin, Vladimir
AU  - Milić, Marija
AU  - Brajković, Denis
AU  - Brković, Božidar
AU  - Stojić, Dragica
AU  - Todorović, Ljubomir
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1660
AB  - Objective. The aim of this study was to investigate quality and safety of supplemental intraoral anesthesia - periodontal ligament anaesthesia (PDL) and intraseptal anaesthesia (ISA) after computer-controlled articaine delivery. Method. 54 ASA I volunteers randomly divided into 2 groups participated in this study. 0.4 ml of 4% articaine with 1:100.000 epinephrine were randomly administered with computer-controlled local anaesthetic delivery system on the mesial and distal side of maxillary lateral incisor for ISA or PDL. An electric pulp tester was used to test the pulpal anaesthesia, in 2-minute cycles for 60 minutes. Anaesthesia was considered successful when 2 or more consecutive no-response at 80 readings were obtained. Soft-tissue anaesthesia was measured by pin-prick test. Results. Success rates for ISA and PDL were 77.8% and 55.6% respectively, but difference was not statistically significant (p>0.05). Duration of complete pulpal anaesthesia was significantly longer (p lt 0.05) with the ISA in comparison to the PDL. The width of anesthetizied field was significantly greater (p lt 0.05) with the ISA than with the PDL, both for attached gingiva and oral mucosa. No side effects were recorded during the study. Conclusion. The results of this study indicate that the ISA technique is successful in obtaining complete pulpal anaesthesia of upper lateral incisors and soft-tissue anaesthesia in this area.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Stomatology
T1  - Efficacy of computer-controlled articaine delivery for supplemental intraoral anaesthesia
VL  - 15
IS  - 1
SP  - 11
EP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_smile_1660
ER  - 

@article{
author = "Biočanin, Vladimir and Milić, Marija and Brajković, Denis and Brković, Božidar and Stojić, Dragica and Todorović, Ljubomir",
year = "2011",
abstract = "Objective. The aim of this study was to investigate quality and safety of supplemental intraoral anesthesia - periodontal ligament anaesthesia (PDL) and intraseptal anaesthesia (ISA) after computer-controlled articaine delivery. Method. 54 ASA I volunteers randomly divided into 2 groups participated in this study. 0.4 ml of 4% articaine with 1:100.000 epinephrine were randomly administered with computer-controlled local anaesthetic delivery system on the mesial and distal side of maxillary lateral incisor for ISA or PDL. An electric pulp tester was used to test the pulpal anaesthesia, in 2-minute cycles for 60 minutes. Anaesthesia was considered successful when 2 or more consecutive no-response at 80 readings were obtained. Soft-tissue anaesthesia was measured by pin-prick test. Results. Success rates for ISA and PDL were 77.8% and 55.6% respectively, but difference was not statistically significant (p>0.05). Duration of complete pulpal anaesthesia was significantly longer (p lt 0.05) with the ISA in comparison to the PDL. The width of anesthetizied field was significantly greater (p lt 0.05) with the ISA than with the PDL, both for attached gingiva and oral mucosa. No side effects were recorded during the study. Conclusion. The results of this study indicate that the ISA technique is successful in obtaining complete pulpal anaesthesia of upper lateral incisors and soft-tissue anaesthesia in this area.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Stomatology",
title = "Efficacy of computer-controlled articaine delivery for supplemental intraoral anaesthesia",
volume = "15",
number = "1",
pages = "11-14",
url = "https://hdl.handle.net/21.15107/rcub_smile_1660"
}

Biočanin, V., Milić, M., Brajković, D., Brković, B., Stojić, D.,& Todorović, L.. (2011). Efficacy of computer-controlled articaine delivery for supplemental intraoral anaesthesia. in Balkan Journal of Stomatology
Udruženje stomatologa Balkana., 15(1), 11-14.
https://hdl.handle.net/21.15107/rcub_smile_1660

Biočanin V, Milić M, Brajković D, Brković B, Stojić D, Todorović L. Efficacy of computer-controlled articaine delivery for supplemental intraoral anaesthesia. in Balkan Journal of Stomatology. 2011;15(1):11-14.
https://hdl.handle.net/21.15107/rcub_smile_1660 .

Biočanin, Vladimir, Milić, Marija, Brajković, Denis, Brković, Božidar, Stojić, Dragica, Todorović, Ljubomir, "Efficacy of computer-controlled articaine delivery for supplemental intraoral anaesthesia" in Balkan Journal of Stomatology, 15, no. 1 (2011):11-14,
https://hdl.handle.net/21.15107/rcub_smile_1660 .