TY  - JOUR
AU  - Bracanović, Đurđa
AU  - Đurić, Marija
AU  - Sopta, Jelena
AU  - Bracanović, Miloš
AU  - Đonić, Danijela
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2505
AB  - Hyperostosis frontalis interna (HFI) presents irregular thickening of the frontal bone. Even though HFI is frequently seen during routine radiological imaging, it usually remains unrecorded owing to a common belief that it just represents an incidental finding or anatomical variant. Recent studies implied that HFI may be clinically relevant. Etiology of HFI is still debated, while presumptions are mainly based on altered sex steroids impact on skull bone growth. Some authors implied that frontal bone might be particularly affected by this condition due to specificity of its underlying dura. In this paper we present a 27-years old female patient with a treatment resistant headache. Head CT showed massive, irregular bony mass, with lobulated contours arising from the right frontal bone, but did not cross the fronto-parietal suture, spearing the superior sagittal sinus and skull midline. After surgery, histopathological analysis of the frontal bone sample in our patient showed thickening pattern similar to those described in micro-CT studies of HFI. Furthermore, in an attempt to test speculation of the possible role of estrogen in pathogenesis of HFI, we investigated the expression of a-estrogen receptors on dura of the frontal region. These analyses confirmed nuclear expression of estrogen on frontal region dural tissue, supporting previous speculation of the development mechanisms of HFI and contributing to a better understanding of this common condition of the frontal bone. Additionally, the presence of HFI may result in severe symptomatology, which could be misinterpreted and related to other disorders if HFI is not radiologicaly recognized and reported.
PB  - Elsevier Gmbh, Munich
T2  - Homo - Journal of Comparative Human Biology
T1  - Radiological evaluation of Hyperostosis frontalis interna: is it of clinical importance?
VL  - 71
IS  - 2
SP  - 155
EP  - 160
DO  - 10.1127/homo/2020/1134
ER  - 

@article{
author = "Bracanović, Đurđa and Đurić, Marija and Sopta, Jelena and Bracanović, Miloš and Đonić, Danijela",
year = "2020",
abstract = "Hyperostosis frontalis interna (HFI) presents irregular thickening of the frontal bone. Even though HFI is frequently seen during routine radiological imaging, it usually remains unrecorded owing to a common belief that it just represents an incidental finding or anatomical variant. Recent studies implied that HFI may be clinically relevant. Etiology of HFI is still debated, while presumptions are mainly based on altered sex steroids impact on skull bone growth. Some authors implied that frontal bone might be particularly affected by this condition due to specificity of its underlying dura. In this paper we present a 27-years old female patient with a treatment resistant headache. Head CT showed massive, irregular bony mass, with lobulated contours arising from the right frontal bone, but did not cross the fronto-parietal suture, spearing the superior sagittal sinus and skull midline. After surgery, histopathological analysis of the frontal bone sample in our patient showed thickening pattern similar to those described in micro-CT studies of HFI. Furthermore, in an attempt to test speculation of the possible role of estrogen in pathogenesis of HFI, we investigated the expression of a-estrogen receptors on dura of the frontal region. These analyses confirmed nuclear expression of estrogen on frontal region dural tissue, supporting previous speculation of the development mechanisms of HFI and contributing to a better understanding of this common condition of the frontal bone. Additionally, the presence of HFI may result in severe symptomatology, which could be misinterpreted and related to other disorders if HFI is not radiologicaly recognized and reported.",
publisher = "Elsevier Gmbh, Munich",
journal = "Homo - Journal of Comparative Human Biology",
title = "Radiological evaluation of Hyperostosis frontalis interna: is it of clinical importance?",
volume = "71",
number = "2",
pages = "155-160",
doi = "10.1127/homo/2020/1134"
}

Bracanović, Đ., Đurić, M., Sopta, J., Bracanović, M.,& Đonić, D.. (2020). Radiological evaluation of Hyperostosis frontalis interna: is it of clinical importance?. in Homo - Journal of Comparative Human Biology
Elsevier Gmbh, Munich., 71(2), 155-160.
https://doi.org/10.1127/homo/2020/1134

Bracanović Đ, Đurić M, Sopta J, Bracanović M, Đonić D. Radiological evaluation of Hyperostosis frontalis interna: is it of clinical importance?. in Homo - Journal of Comparative Human Biology. 2020;71(2):155-160.
doi:10.1127/homo/2020/1134 .

Bracanović, Đurđa, Đurić, Marija, Sopta, Jelena, Bracanović, Miloš, Đonić, Danijela, "Radiological evaluation of Hyperostosis frontalis interna: is it of clinical importance?" in Homo - Journal of Comparative Human Biology, 71, no. 2 (2020):155-160,
https://doi.org/10.1127/homo/2020/1134 . .

TY  - JOUR
AU  - Đonić, Danijela
AU  - Bracanović, Đurđa
AU  - Rakočević, Zoran
AU  - Ivović, Miomira
AU  - Nikolić, Slobodan
AU  - Živković, Vladimir
AU  - Đurić, Marija
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2119
AB  - To improve our understanding of hyperostosis frontalis interna (HFI), we investigated whether HFI was accompanied by changes in the postcranial skeleton. Based on head CT scan analyses, 103 postmenopausal women were divided into controls without HFI and those with HFI, in whom we measured the thickness of frontal, occipital, and parietal bones. Women in the study underwent dual energy x-ray absorptiometry to analyze the bone density of the hip and vertebral region and external geometry of the proximal femora. Additionally, all of the women completed a questionnaire about symptoms and conditions that could be related to HFI. Women with HFI had a significantly higher prevalence of headaches, neurological and psychiatric disorders, and a significantly lower prevalence of having given birth. Increased bone thickness and altered bone structure in women with HFI was localized only on the skull, particularly on the frontal bone, probably due to specific properties of its underlying dura. Bone loss in the postcranial skeleton showed the same pattern in postmenopausal women with HFI as in those without HFI. Recording of HFI in medical records can be helpful in distinguishing whether reported disorders occur as a consequence of HFI or are related to other diseases, but does not appear helpful in identifying women at risk of bone loss.
PB  - Routledge Journals, Taylor & Francis Ltd, Abingdon
T2  - Women & Health
T1  - Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis
VL  - 56
IS  - 8
SP  - 994
EP  - 1007
DO  - 10.1080/03630242.2016.1178685
ER  - 

@article{
author = "Đonić, Danijela and Bracanović, Đurđa and Rakočević, Zoran and Ivović, Miomira and Nikolić, Slobodan and Živković, Vladimir and Đurić, Marija",
year = "2016",
abstract = "To improve our understanding of hyperostosis frontalis interna (HFI), we investigated whether HFI was accompanied by changes in the postcranial skeleton. Based on head CT scan analyses, 103 postmenopausal women were divided into controls without HFI and those with HFI, in whom we measured the thickness of frontal, occipital, and parietal bones. Women in the study underwent dual energy x-ray absorptiometry to analyze the bone density of the hip and vertebral region and external geometry of the proximal femora. Additionally, all of the women completed a questionnaire about symptoms and conditions that could be related to HFI. Women with HFI had a significantly higher prevalence of headaches, neurological and psychiatric disorders, and a significantly lower prevalence of having given birth. Increased bone thickness and altered bone structure in women with HFI was localized only on the skull, particularly on the frontal bone, probably due to specific properties of its underlying dura. Bone loss in the postcranial skeleton showed the same pattern in postmenopausal women with HFI as in those without HFI. Recording of HFI in medical records can be helpful in distinguishing whether reported disorders occur as a consequence of HFI or are related to other diseases, but does not appear helpful in identifying women at risk of bone loss.",
publisher = "Routledge Journals, Taylor & Francis Ltd, Abingdon",
journal = "Women & Health",
title = "Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis",
volume = "56",
number = "8",
pages = "994-1007",
doi = "10.1080/03630242.2016.1178685"
}

Đonić, D., Bracanović, Đ., Rakočević, Z., Ivović, M., Nikolić, S., Živković, V.,& Đurić, M.. (2016). Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis. in Women & Health
Routledge Journals, Taylor & Francis Ltd, Abingdon., 56(8), 994-1007.
https://doi.org/10.1080/03630242.2016.1178685

Đonić D, Bracanović Đ, Rakočević Z, Ivović M, Nikolić S, Živković V, Đurić M. Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis. in Women & Health. 2016;56(8):994-1007.
doi:10.1080/03630242.2016.1178685 .

Đonić, Danijela, Bracanović, Đurđa, Rakočević, Zoran, Ivović, Miomira, Nikolić, Slobodan, Živković, Vladimir, Đurić, Marija, "Hyperostosis frontalis interna in postmenopausal womenPossible relation to osteoporosis" in Women & Health, 56, no. 8 (2016):994-1007,
https://doi.org/10.1080/03630242.2016.1178685 . .

TY  - JOUR
AU  - Bracanović, Đurđa
AU  - Đonić, Danijela
AU  - Nikolić, Slobodan
AU  - Milovanović, Petar
AU  - Rakočević, Zoran
AU  - Živković, Vladimir
AU  - Đurić, Marija
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2105
AB  - Although seen frequently during dissections and autopsies, Hyperostosis frontalis interna (HFI) - a morphological pattern of the frontal bone thickening - is often ignored and its nature and development are not yet understood sufficiently. Current macroscopic classification defines four grades/stages of HFI based on the morphological appearance and size of the affected area; however, it is unclear if these stages also depict the successive phases in the HFI development. Here we assessed 3D-microarchitecture of the frontal bone in women with various degrees of HFI expression and in an age- and sex-matched control group, hypothesizing that the bone microarchitecture bears imprints of the pathogenesis of HFI and may clarify the phases of its development. Frontal bone samples were collected during routine autopsies from 20 women with HFI (age: 69.9 +/- 11.1years) and 14 women without HFI (age: 74.1 +/- 9.7years). We classified the HFI samples into four groups, each group demonstrating different macroscopic type or stage of HFI. All samples were scanned by micro-computed tomography to evaluate 3D bone microarchitecture in the following regions of interest: total sample, outer table, diploe and inner table. Our results revealed that, compared to the control group, the women with HFI showed a significantly increased bone volume fraction in the region of diploe, along with significantly thicker and more plate-like shaped trabeculae and reduced trabecular separation and connectivity density. Moreover, the inner table of the frontal bone in women with HFI displayed significantly increased total porosity and mean pore diameter compared to controls. Microstructural reorganization of the frontal bone in women with HFI was also reflected in significantly higher porosity and lower bone volume fraction in the inner vs. outer table due to an increased number of pores larger than 100m. The individual comparisons between the control group and different macroscopic stages of HFI revealed significant differences only between the control group and the morphologically most pronounced type of HFI. Our microarchitectural findings demonstrated clear differences between the HFI and the control group in the region of diploe and the inner table. Macroscopic grades of HFI could not be distinguished at the level of bone microarchitecture and their consecutive nature cannot be supported. Rather, our study suggests that only two different types of HFI (moderate and severe HFI) have microstructural justification and should be considered further. It is essential to record HFI systematically in human postmortem subjects to provide more data on the mechanisms of its development.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Anatomy
T1  - 3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women
VL  - 229
IS  - 5
SP  - 673
EP  - 680
DO  - 10.1111/joa.12506
ER  - 

@article{
author = "Bracanović, Đurđa and Đonić, Danijela and Nikolić, Slobodan and Milovanović, Petar and Rakočević, Zoran and Živković, Vladimir and Đurić, Marija",
year = "2016",
abstract = "Although seen frequently during dissections and autopsies, Hyperostosis frontalis interna (HFI) - a morphological pattern of the frontal bone thickening - is often ignored and its nature and development are not yet understood sufficiently. Current macroscopic classification defines four grades/stages of HFI based on the morphological appearance and size of the affected area; however, it is unclear if these stages also depict the successive phases in the HFI development. Here we assessed 3D-microarchitecture of the frontal bone in women with various degrees of HFI expression and in an age- and sex-matched control group, hypothesizing that the bone microarchitecture bears imprints of the pathogenesis of HFI and may clarify the phases of its development. Frontal bone samples were collected during routine autopsies from 20 women with HFI (age: 69.9 +/- 11.1years) and 14 women without HFI (age: 74.1 +/- 9.7years). We classified the HFI samples into four groups, each group demonstrating different macroscopic type or stage of HFI. All samples were scanned by micro-computed tomography to evaluate 3D bone microarchitecture in the following regions of interest: total sample, outer table, diploe and inner table. Our results revealed that, compared to the control group, the women with HFI showed a significantly increased bone volume fraction in the region of diploe, along with significantly thicker and more plate-like shaped trabeculae and reduced trabecular separation and connectivity density. Moreover, the inner table of the frontal bone in women with HFI displayed significantly increased total porosity and mean pore diameter compared to controls. Microstructural reorganization of the frontal bone in women with HFI was also reflected in significantly higher porosity and lower bone volume fraction in the inner vs. outer table due to an increased number of pores larger than 100m. The individual comparisons between the control group and different macroscopic stages of HFI revealed significant differences only between the control group and the morphologically most pronounced type of HFI. Our microarchitectural findings demonstrated clear differences between the HFI and the control group in the region of diploe and the inner table. Macroscopic grades of HFI could not be distinguished at the level of bone microarchitecture and their consecutive nature cannot be supported. Rather, our study suggests that only two different types of HFI (moderate and severe HFI) have microstructural justification and should be considered further. It is essential to record HFI systematically in human postmortem subjects to provide more data on the mechanisms of its development.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Anatomy",
title = "3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women",
volume = "229",
number = "5",
pages = "673-680",
doi = "10.1111/joa.12506"
}

Bracanović, Đ., Đonić, D., Nikolić, S., Milovanović, P., Rakočević, Z., Živković, V.,& Đurić, M.. (2016). 3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women. in Journal of Anatomy
Wiley-Blackwell, Hoboken., 229(5), 673-680.
https://doi.org/10.1111/joa.12506

Bracanović Đ, Đonić D, Nikolić S, Milovanović P, Rakočević Z, Živković V, Đurić M. 3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women. in Journal of Anatomy. 2016;229(5):673-680.
doi:10.1111/joa.12506 .

Bracanović, Đurđa, Đonić, Danijela, Nikolić, Slobodan, Milovanović, Petar, Rakočević, Zoran, Živković, Vladimir, Đurić, Marija, "3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged women" in Journal of Anatomy, 229, no. 5 (2016):673-680,
https://doi.org/10.1111/joa.12506 . .

TY  - JOUR
AU  - Bracanović, Đurđa
AU  - Đurić, Marija
AU  - Sopta, Jelena
AU  - Đonić, Danijela
AU  - Lujić, Nenad
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1831
AB  - Although Serbia is recognized as an endemic country for echinococcosis, no information about precise incidence in humans has been available. The aim of this study was to investigate the skeletal manifestations of hydatid disease in Serbia. This retrospective study was conducted by reviewing the medical database of Institute for Pathology (Faculty of Medicine in Belgrade), a reference institution for bone pathology in Serbia. We reported a total of 41 patients with bone cystic echinococcosis (CE) during the study period. The mean age of 41 patients was 40.9 +/- 18.8 years. In 39% of patients, the fracture line was the only visible radiological sign, followed by cyst and tumefaction. The spine was the most commonly involved skeletal site (55.8%), followed by the femur (18.6%), pelvis (13.9%), humerus (7.0%), rib (2.3%), and tibia (2.3%). Pain was the symptom in 41.5% of patients, while some patients demonstrated complications such as paraplegia (22.0%), pathologic fracture (48.8%), and scoliosis (9.8%). The pathological fracture most frequently affected the spine (75.0%) followed by the femur (20.0%) and tibia (5.0%). However, 19.5% of patients didn't develop any complication or symptom. In this study, we showed that bone CE is not uncommon in Serbian population. As reported in the literature, therapy of bone CE is controversial and its results are poor. In order to improve the therapy outcome, early diagnosis, before symptoms and complications occur, can be contributive.
PB  - Korean Soc Parasitology, Seoul Natl Univ Coll Medi, Seoul
T2  - Korean Journal of Parasitology
T1  - Skeletal Manifestations of Hydatid Disease in Serbia: Demographic Distribution, Site Involvement, Radiological Findings, and Complications
VL  - 51
IS  - 4
SP  - 453
EP  - 459
DO  - 10.3347/kjp.2013.51.4.453
ER  - 

@article{
author = "Bracanović, Đurđa and Đurić, Marija and Sopta, Jelena and Đonić, Danijela and Lujić, Nenad",
year = "2013",
abstract = "Although Serbia is recognized as an endemic country for echinococcosis, no information about precise incidence in humans has been available. The aim of this study was to investigate the skeletal manifestations of hydatid disease in Serbia. This retrospective study was conducted by reviewing the medical database of Institute for Pathology (Faculty of Medicine in Belgrade), a reference institution for bone pathology in Serbia. We reported a total of 41 patients with bone cystic echinococcosis (CE) during the study period. The mean age of 41 patients was 40.9 +/- 18.8 years. In 39% of patients, the fracture line was the only visible radiological sign, followed by cyst and tumefaction. The spine was the most commonly involved skeletal site (55.8%), followed by the femur (18.6%), pelvis (13.9%), humerus (7.0%), rib (2.3%), and tibia (2.3%). Pain was the symptom in 41.5% of patients, while some patients demonstrated complications such as paraplegia (22.0%), pathologic fracture (48.8%), and scoliosis (9.8%). The pathological fracture most frequently affected the spine (75.0%) followed by the femur (20.0%) and tibia (5.0%). However, 19.5% of patients didn't develop any complication or symptom. In this study, we showed that bone CE is not uncommon in Serbian population. As reported in the literature, therapy of bone CE is controversial and its results are poor. In order to improve the therapy outcome, early diagnosis, before symptoms and complications occur, can be contributive.",
publisher = "Korean Soc Parasitology, Seoul Natl Univ Coll Medi, Seoul",
journal = "Korean Journal of Parasitology",
title = "Skeletal Manifestations of Hydatid Disease in Serbia: Demographic Distribution, Site Involvement, Radiological Findings, and Complications",
volume = "51",
number = "4",
pages = "453-459",
doi = "10.3347/kjp.2013.51.4.453"
}

Bracanović, Đ., Đurić, M., Sopta, J., Đonić, D.,& Lujić, N.. (2013). Skeletal Manifestations of Hydatid Disease in Serbia: Demographic Distribution, Site Involvement, Radiological Findings, and Complications. in Korean Journal of Parasitology
Korean Soc Parasitology, Seoul Natl Univ Coll Medi, Seoul., 51(4), 453-459.
https://doi.org/10.3347/kjp.2013.51.4.453

Bracanović Đ, Đurić M, Sopta J, Đonić D, Lujić N. Skeletal Manifestations of Hydatid Disease in Serbia: Demographic Distribution, Site Involvement, Radiological Findings, and Complications. in Korean Journal of Parasitology. 2013;51(4):453-459.
doi:10.3347/kjp.2013.51.4.453 .

Bracanović, Đurđa, Đurić, Marija, Sopta, Jelena, Đonić, Danijela, Lujić, Nenad, "Skeletal Manifestations of Hydatid Disease in Serbia: Demographic Distribution, Site Involvement, Radiological Findings, and Complications" in Korean Journal of Parasitology, 51, no. 4 (2013):453-459,
https://doi.org/10.3347/kjp.2013.51.4.453 . .