@article{
author = "Ilic-Dimitrijević, Ivana and Loening, Thomas and Falk, Marcus and Konstantinović, Vitomir and Vukadinović, Miroslav and Tepavčević, Zvezdana and Tabaković, Saša Z. and Pejčić, Nataša and Miličić, Biljana and Milašin, Jelena",
year = "2014",
abstract = "Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas.",
publisher = "Društvo genetičara Srbije, Beograd",
journal = "Genetika - Belgrade",
title = "Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma",
volume = "46",
number = "2",
pages = "601-610",
doi = "10.2298/GENSR1402601D"
}