TY  - JOUR
AU  - Ristić, Ljubisa
AU  - Daković, Dragana
AU  - Poštić, Srđan
AU  - Lazić, Zoran
AU  - Baćević, Miljana
AU  - Vucević, Dragana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2467
AB  - Purpose The grey-bluish discoloration of gingiva (known as "amalgam tattoo") does not appear only in the presence of amalgam restorations. It may also be seen in cases of teeth restored with cast dowels and porcelain-fused-to-metal (PFM) restorations. The aim of this article was to determine the clinical characteristics of abutment teeth with gingival discoloration. Materials and Methods This research was conducted on 25 patients referred for cast dowel and PFM restorations. These restorations were manufactured from Ni-Cr alloys. Ninety days after cementing the fixed prosthodontic restorations, the abutment teeth (n = 61) were divided into a group with gingival discoloration (GD) (n = 25) and without gingival discoloration (NGD) (n = 36). The control group (CG) comprised the contralateral teeth (n = 61). Plaque index, gingival index, clinical attachment level, and probing depth were assessed before fabrication and also 90 days after cementation of the PFM restorations. Results The gingival index, clinical attachment level, and probing depths of the abutment teeth that had GD were statistically higher before restoration, in comparison with the abutment teeth in the NGD and control groups. Ninety days after cementation, the abutment teeth with GD had significantly lower gingival indexes and probing depths, compared to the abutment teeth in the NGD group. Both abutment teeth groups (GD and NGD) had significantly higher values of clinical attachment levels when compared to the control group. There were no statistically significant differences in plaque index values between the study groups. Conclusions The results of this study indicated that impairment of periodontal status of abutment teeth seemed to be related to the presence of gingival discolorations. Therefore, fabrication of fixed prosthodontic restorations requires careful planning and abutment teeth preparation to minimize the occurrence of gingival discolorations. Clinical relevance: With careful preparation of abutment teeth for cast dowels and crown restorations it may be possible to decrease the frequency of gingival discolorations adjacent to abutment teeth.
PB  - Wiley, Hoboken
T2  - Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry
T1  - Clinical Characteristics of Abutment Teeth with Gingival Discoloration
VL  - 28
IS  - 1
SP  - E45
EP  - E50
DO  - 10.1111/jopr.12612
ER  - 

@article{
author = "Ristić, Ljubisa and Daković, Dragana and Poštić, Srđan and Lazić, Zoran and Baćević, Miljana and Vucević, Dragana",
year = "2019",
abstract = "Purpose The grey-bluish discoloration of gingiva (known as "amalgam tattoo") does not appear only in the presence of amalgam restorations. It may also be seen in cases of teeth restored with cast dowels and porcelain-fused-to-metal (PFM) restorations. The aim of this article was to determine the clinical characteristics of abutment teeth with gingival discoloration. Materials and Methods This research was conducted on 25 patients referred for cast dowel and PFM restorations. These restorations were manufactured from Ni-Cr alloys. Ninety days after cementing the fixed prosthodontic restorations, the abutment teeth (n = 61) were divided into a group with gingival discoloration (GD) (n = 25) and without gingival discoloration (NGD) (n = 36). The control group (CG) comprised the contralateral teeth (n = 61). Plaque index, gingival index, clinical attachment level, and probing depth were assessed before fabrication and also 90 days after cementation of the PFM restorations. Results The gingival index, clinical attachment level, and probing depths of the abutment teeth that had GD were statistically higher before restoration, in comparison with the abutment teeth in the NGD and control groups. Ninety days after cementation, the abutment teeth with GD had significantly lower gingival indexes and probing depths, compared to the abutment teeth in the NGD group. Both abutment teeth groups (GD and NGD) had significantly higher values of clinical attachment levels when compared to the control group. There were no statistically significant differences in plaque index values between the study groups. Conclusions The results of this study indicated that impairment of periodontal status of abutment teeth seemed to be related to the presence of gingival discolorations. Therefore, fabrication of fixed prosthodontic restorations requires careful planning and abutment teeth preparation to minimize the occurrence of gingival discolorations. Clinical relevance: With careful preparation of abutment teeth for cast dowels and crown restorations it may be possible to decrease the frequency of gingival discolorations adjacent to abutment teeth.",
publisher = "Wiley, Hoboken",
journal = "Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry",
title = "Clinical Characteristics of Abutment Teeth with Gingival Discoloration",
volume = "28",
number = "1",
pages = "E45-E50",
doi = "10.1111/jopr.12612"
}

Ristić, L., Daković, D., Poštić, S., Lazić, Z., Baćević, M.,& Vucević, D.. (2019). Clinical Characteristics of Abutment Teeth with Gingival Discoloration. in Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry
Wiley, Hoboken., 28(1), E45-E50.
https://doi.org/10.1111/jopr.12612

Ristić L, Daković D, Poštić S, Lazić Z, Baćević M, Vucević D. Clinical Characteristics of Abutment Teeth with Gingival Discoloration. in Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry. 2019;28(1):E45-E50.
doi:10.1111/jopr.12612 .

Ristić, Ljubisa, Daković, Dragana, Poštić, Srđan, Lazić, Zoran, Baćević, Miljana, Vucević, Dragana, "Clinical Characteristics of Abutment Teeth with Gingival Discoloration" in Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry, 28, no. 1 (2019):E45-E50,
https://doi.org/10.1111/jopr.12612 . .

TY  - JOUR
AU  - Miletić, Ana
AU  - Lazić, Zoran
AU  - Todorović, Ana
AU  - Đorđević, Igor
AU  - Popović, Danica
AU  - Lazić, Vojkan
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2332
AB  - Background/Aim. Many studies investigated association between stress, anxiety or personality traits and sleep bruxism (SB), but results are still contradictory. We aimed to investigate whether there is a relation between clinically diagnosed sleep bruxism and salivary cortisol levels as one of the major stress biomarkers and to examine psychological factors and personality traits specific to sleep bruxism. Methods. A total of 23 sleep bruxism patients and 42 healthy non-sleep bruxism adults participated in this study. Diagnose of sleep-bruxism was assessed by self-report and clinical examination and also confirmed by bed-partner. Morning saliva was collected from all participants for analyses of the cortisol level. Sleep bruxism patients underwent a psychodiagnostic personality interpretation using the Minnesota Multiphasic Personality Inventory - MMPI-202 test. Results. Statistically significant difference between levels of morning salivary cortisol in the group of SB patients and the control group was recorded (t = 2.943, p  lt  0.01). Analysis of the personality profiles indicated that the sleep bruxism patients avoid contact with unpleasant feelings, especially depression, suppress the aggression and censor the expression of anger and rage. Conclusion. This study showed that patients with sleep bruxism have higher levels of salivary cortisol. Personality traits such as depression, hypomania and suppressed aggression were found to be common characteristics in patients with sleep bruxism. Present findings might support the hypothesis that sleep bruxism and psychological states such as stress may be related, but the cross-sectional nature of this study does not allow us to draw conclusions about the causal relationship between stress, personality traits and sleep bruxism.
AB  - Uvod/Cilj. Mnoge studije ispitivale su povezanost između stresa, anksioznosti, crta ličnosti i bruksizma, ali su rezultati i dalje kontradiktorni. Cilj ove studije bio je da se ispita da li postoji povezanost između klinički dijagnostikovanog bruksizma koji se javlja tokom spavanja i koncentracije kortizola u salivi koja se smatra jednim od glavnih biomarkera stresa, kao i da se ispitaju psihološki faktori i crte ličnosti osoba sa bruksizmom. Metode. Studija je obuhvatila 23 bolesnika sa bruksizmom i 42 zdrava ispitanika bez znakova bruksizma. Dijagnoza bruksizma uspostavljena je na osnovu spostvene izjave i kliničkog pregleda kao i potvrde partnera. Uzorci jutarnje pljuvačke prikupljani su radi analize kortizola. Bolesnici sa bruksizmom podvrgnuti su psihodijagnostičkom ispitivanju pomoću Minesota multifaznog testa ličnosti - MMPI-202. Rezultati. U grupi bolesnika sa bruksizmom registrovana je značajno veća koncentracija kortizola u pljuvačci u poređenju sa pacijentima bez znakova bruksizma (t = 2.943, p  lt  0.01). Psihodijagnostička interpretacija profila ličnosti pokazala je da ispitanike sa bruksizmom karakteriše izbegavanje kontakta sa neprijatnim osećanjima, posebno depresijom i potiskivanje agresivnosti, odnosno izražena autocenzura na otvoreno ispoljavanje ljutnje i besa. Zaključak. Kod bolesnika sa bruksizmom registrovane su povećane koncentracije kortizola u salivi. Psihodijagnostička analiza ukazuje da su depresija, hipomanija i supresija agresije izražene kod bolesnika sa bruksizmom. Nalazi bi mogli da podrže hipotezu povezanosti bruksizma u toku spavanja i stresa, ali priroda ove studije ne dozvoljava izvođenje zaključaka o uzročnoj povezanosti stresa, crta ličnosti i bruksizma u toku spavanja.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Stress assessment in patients with clinically diagnosed sleep bruxism
T1  - Procena stresa kod bolesnika sa klinički dijagnostikovanim bruksizmom
VL  - 75
IS  - 10
SP  - 1014
EP  - 1019
DO  - 10.2298/VSP160902029M
ER  - 

@article{
author = "Miletić, Ana and Lazić, Zoran and Todorović, Ana and Đorđević, Igor and Popović, Danica and Lazić, Vojkan",
year = "2018",
abstract = "Background/Aim. Many studies investigated association between stress, anxiety or personality traits and sleep bruxism (SB), but results are still contradictory. We aimed to investigate whether there is a relation between clinically diagnosed sleep bruxism and salivary cortisol levels as one of the major stress biomarkers and to examine psychological factors and personality traits specific to sleep bruxism. Methods. A total of 23 sleep bruxism patients and 42 healthy non-sleep bruxism adults participated in this study. Diagnose of sleep-bruxism was assessed by self-report and clinical examination and also confirmed by bed-partner. Morning saliva was collected from all participants for analyses of the cortisol level. Sleep bruxism patients underwent a psychodiagnostic personality interpretation using the Minnesota Multiphasic Personality Inventory - MMPI-202 test. Results. Statistically significant difference between levels of morning salivary cortisol in the group of SB patients and the control group was recorded (t = 2.943, p  lt  0.01). Analysis of the personality profiles indicated that the sleep bruxism patients avoid contact with unpleasant feelings, especially depression, suppress the aggression and censor the expression of anger and rage. Conclusion. This study showed that patients with sleep bruxism have higher levels of salivary cortisol. Personality traits such as depression, hypomania and suppressed aggression were found to be common characteristics in patients with sleep bruxism. Present findings might support the hypothesis that sleep bruxism and psychological states such as stress may be related, but the cross-sectional nature of this study does not allow us to draw conclusions about the causal relationship between stress, personality traits and sleep bruxism., Uvod/Cilj. Mnoge studije ispitivale su povezanost između stresa, anksioznosti, crta ličnosti i bruksizma, ali su rezultati i dalje kontradiktorni. Cilj ove studije bio je da se ispita da li postoji povezanost između klinički dijagnostikovanog bruksizma koji se javlja tokom spavanja i koncentracije kortizola u salivi koja se smatra jednim od glavnih biomarkera stresa, kao i da se ispitaju psihološki faktori i crte ličnosti osoba sa bruksizmom. Metode. Studija je obuhvatila 23 bolesnika sa bruksizmom i 42 zdrava ispitanika bez znakova bruksizma. Dijagnoza bruksizma uspostavljena je na osnovu spostvene izjave i kliničkog pregleda kao i potvrde partnera. Uzorci jutarnje pljuvačke prikupljani su radi analize kortizola. Bolesnici sa bruksizmom podvrgnuti su psihodijagnostičkom ispitivanju pomoću Minesota multifaznog testa ličnosti - MMPI-202. Rezultati. U grupi bolesnika sa bruksizmom registrovana je značajno veća koncentracija kortizola u pljuvačci u poređenju sa pacijentima bez znakova bruksizma (t = 2.943, p  lt  0.01). Psihodijagnostička interpretacija profila ličnosti pokazala je da ispitanike sa bruksizmom karakteriše izbegavanje kontakta sa neprijatnim osećanjima, posebno depresijom i potiskivanje agresivnosti, odnosno izražena autocenzura na otvoreno ispoljavanje ljutnje i besa. Zaključak. Kod bolesnika sa bruksizmom registrovane su povećane koncentracije kortizola u salivi. Psihodijagnostička analiza ukazuje da su depresija, hipomanija i supresija agresije izražene kod bolesnika sa bruksizmom. Nalazi bi mogli da podrže hipotezu povezanosti bruksizma u toku spavanja i stresa, ali priroda ove studije ne dozvoljava izvođenje zaključaka o uzročnoj povezanosti stresa, crta ličnosti i bruksizma u toku spavanja.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Stress assessment in patients with clinically diagnosed sleep bruxism, Procena stresa kod bolesnika sa klinički dijagnostikovanim bruksizmom",
volume = "75",
number = "10",
pages = "1014-1019",
doi = "10.2298/VSP160902029M"
}

Miletić, A., Lazić, Z., Todorović, A., Đorđević, I., Popović, D.,& Lazić, V.. (2018). Stress assessment in patients with clinically diagnosed sleep bruxism. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(10), 1014-1019.
https://doi.org/10.2298/VSP160902029M

Miletić A, Lazić Z, Todorović A, Đorđević I, Popović D, Lazić V. Stress assessment in patients with clinically diagnosed sleep bruxism. in Vojnosanitetski pregled. 2018;75(10):1014-1019.
doi:10.2298/VSP160902029M .

Miletić, Ana, Lazić, Zoran, Todorović, Ana, Đorđević, Igor, Popović, Danica, Lazić, Vojkan, "Stress assessment in patients with clinically diagnosed sleep bruxism" in Vojnosanitetski pregled, 75, no. 10 (2018):1014-1019,
https://doi.org/10.2298/VSP160902029M . .

TY  - JOUR
AU  - Vlahović, Zoran
AU  - Marković, Aleksa
AU  - Lazić, Zoran
AU  - Šćepanović, Miodrag
AU  - Đinić, Ana
AU  - Kalanović, Milena
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2219
AB  - AimTo evaluate by histopathological analysis the peri-implant bone inflammation degree, in certain time intervals (7, 14, 21 and 28days), following mini-incision flapless and flap implant placement. Material and methodsThe experiment was conducted on four domestic pigs. Nine weeks prior to implant insertion, second and third mandibular premolars were extracted. Each animal received six implants in lower jaw. On one randomly chosen side of jaw flapless technique using mini-incision was performed, while on the other side implants were inserted after flap raising. After 7, 14, 21, and 28days, the experimental animals were sacrificed. Following mandibular resection and decalcification, the samples for histopathological analysis of the peri-implant bone were obtained in the empty implant bed area, from the buccal side of the mandible, adjacent to implant neck region and parallel to crestal edge of implant bed. The degree of inflammatory response of the peri-implant bone was estimated through ordinal scores from 0 to 2. ResultsSeven days after the surgery all samples in the flap group had score 2 indicating high inflammation degree, in contrast to lower inflammatory reaction in flapless group. On the 14th and 21st postoperative day decreasing of inflammation degree was noted in all samples of the flapless group (score 1), while in flap group samples presented scores 1 and 2. Twenty-eight days after the implant placement, further reduction of inflammation in the flapless group (33% of samples had score 0) was observed. ConclusionFlapless technique in comparison to conventional flap procedure minimizes postoperative bone inflammatory reactions.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs
VL  - 28
IS  - 9
SP  - 1067
EP  - 1073
DO  - 10.1111/clr.12919
ER  - 

@article{
author = "Vlahović, Zoran and Marković, Aleksa and Lazić, Zoran and Šćepanović, Miodrag and Đinić, Ana and Kalanović, Milena",
year = "2017",
abstract = "AimTo evaluate by histopathological analysis the peri-implant bone inflammation degree, in certain time intervals (7, 14, 21 and 28days), following mini-incision flapless and flap implant placement. Material and methodsThe experiment was conducted on four domestic pigs. Nine weeks prior to implant insertion, second and third mandibular premolars were extracted. Each animal received six implants in lower jaw. On one randomly chosen side of jaw flapless technique using mini-incision was performed, while on the other side implants were inserted after flap raising. After 7, 14, 21, and 28days, the experimental animals were sacrificed. Following mandibular resection and decalcification, the samples for histopathological analysis of the peri-implant bone were obtained in the empty implant bed area, from the buccal side of the mandible, adjacent to implant neck region and parallel to crestal edge of implant bed. The degree of inflammatory response of the peri-implant bone was estimated through ordinal scores from 0 to 2. ResultsSeven days after the surgery all samples in the flap group had score 2 indicating high inflammation degree, in contrast to lower inflammatory reaction in flapless group. On the 14th and 21st postoperative day decreasing of inflammation degree was noted in all samples of the flapless group (score 1), while in flap group samples presented scores 1 and 2. Twenty-eight days after the implant placement, further reduction of inflammation in the flapless group (33% of samples had score 0) was observed. ConclusionFlapless technique in comparison to conventional flap procedure minimizes postoperative bone inflammatory reactions.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs",
volume = "28",
number = "9",
pages = "1067-1073",
doi = "10.1111/clr.12919"
}

Vlahović, Z., Marković, A., Lazić, Z., Šćepanović, M., Đinić, A.,& Kalanović, M.. (2017). Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs. in Clinical Oral Implants Research
Wiley, Hoboken., 28(9), 1067-1073.
https://doi.org/10.1111/clr.12919

Vlahović Z, Marković A, Lazić Z, Šćepanović M, Đinić A, Kalanović M. Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs. in Clinical Oral Implants Research. 2017;28(9):1067-1073.
doi:10.1111/clr.12919 .

Vlahović, Zoran, Marković, Aleksa, Lazić, Zoran, Šćepanović, Miodrag, Đinić, Ana, Kalanović, Milena, "Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs" in Clinical Oral Implants Research, 28, no. 9 (2017):1067-1073,
https://doi.org/10.1111/clr.12919 . .

TY  - JOUR
AU  - Rakašević, Dragana
AU  - Lazić, Zoran
AU  - Rakonjac, Bojan
AU  - Soldatović, Ivan
AU  - Janković, Saša
AU  - Magić, Marko
AU  - Aleksić, Zoran
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2174
AB  - Introduction Peri-implantitis is an inflammatory lesion of peri-implant tissues. Eradication of the causative bacteria and decontamination of the implant surface is essential in achieving predictable and stabile clinical results. Photodynamic therapy (PDT) is non-invasive adjuvant therapeutic method to surgery in the treatment of bacterial infection. Objective The aim of this study was to evaluate early clinical and microbiological outcomes of periimplantitis after surgical therapy with adjuvant PDT. Methods Fifty-two diagnosed peri-implantitis sites were divided into two groups. PDT was used for decontamination of implant surface in the study group; in the control group, chlorhexidine gel (CHX) followed by saline irrigation was applied. Several clinical parameters were recorded before the treatment (baseline values) and three months after surgical treatment. Samples for microbiological identification were collected before therapy, during the surgical therapy (before and after decontamination of implant surface), and three months thereafter, and analyzed with identification systems using biochemical analysis. Results The use of PDT resulted in significant decrease of bleeding on probing in comparison to CHX (p  lt  0.001). It showed significant decontamination of implant surfaces with complete elimination of anaerobic bacteria immediately after surgical procedure and three months later. Conclusion The results indicate that PDT can be used as an adjuvant therapy to surgery for decontamination of implant surface and surrounding peri-implant tissues within the treatment of peri-implantitis.
AB  - Uvod Periimplantitis je inflamatorni proces koji zahvata meka tkiva i potpornu kost oko oseointegrisanog implantata. Eliminacija patogenih mikroorganizama i dekontaminacija implantne površine predstavlju najbitniji korak u postizanju stabilnih kliničkih rezultata. Fotodinamska terapija (FDT) predstavlja dodatni neinvazivni metod u terapiji bakterijskih infekcija. Cilj rada Cilj rada bila je procena kliničkih i mikrobioloških parametara nakon hirurške terapije periimplantitisa uz dodatnu primenu FDT. Metode rada Sva dijagnostikovana mesta periimplantitisa (n = 52) bila su podeljena u dve grupe: u studijskoj grupi, za dekontaminaciju implantne površine tokom hirurške procedure korišćena je FDT; u kontrolnoj grupi, za dekontaminaciju implantne površine korišćen je hlorheksidin u gelu (CHX). Klinički parametri praćeni su pre terapijske procedure i tri meseca posle terapije. Uzorci za mikrobiološku analizu uzimani su pre i tri meseca posle terapije, kao i tokom hirurške procedure, pre i posle dekontaminacije implantne površine. Za identifikaciju izolovanih anaeroba korišćen je sistem koji radi po principu biohemijske analize izolovanih mikrobioloških sojeva. Rezultati studije su pokazali da primenom FDT dolazi do znatne redukcije krvarenja na provokaciju u poređenju sa primenom CHX (p  lt  0,001). Primena FDT, kao pomoćnog terapijskog sredstva, omogućava potpunu eliminaciju anaerobnih bakterija sa implantne površine. Zaključak Rezultati pokazuju da FDT može da se koristi kao pomoćno terapijsko sredstvo za dekontaminaciju implantne površine i periimplantnog tkiva u okviru terapije periimplantitisa.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial
T1  - Procena efikasnosti fotodinamske terapije u terapiji periimplantitisa posle tri meseca - randomizirana kontrolisana klinička studija
VL  - 144
IS  - 9-10
SP  - 478
EP  - 484
DO  - 10.2298/sarh1610478r
ER  - 

@article{
author = "Rakašević, Dragana and Lazić, Zoran and Rakonjac, Bojan and Soldatović, Ivan and Janković, Saša and Magić, Marko and Aleksić, Zoran",
year = "2016",
abstract = "Introduction Peri-implantitis is an inflammatory lesion of peri-implant tissues. Eradication of the causative bacteria and decontamination of the implant surface is essential in achieving predictable and stabile clinical results. Photodynamic therapy (PDT) is non-invasive adjuvant therapeutic method to surgery in the treatment of bacterial infection. Objective The aim of this study was to evaluate early clinical and microbiological outcomes of periimplantitis after surgical therapy with adjuvant PDT. Methods Fifty-two diagnosed peri-implantitis sites were divided into two groups. PDT was used for decontamination of implant surface in the study group; in the control group, chlorhexidine gel (CHX) followed by saline irrigation was applied. Several clinical parameters were recorded before the treatment (baseline values) and three months after surgical treatment. Samples for microbiological identification were collected before therapy, during the surgical therapy (before and after decontamination of implant surface), and three months thereafter, and analyzed with identification systems using biochemical analysis. Results The use of PDT resulted in significant decrease of bleeding on probing in comparison to CHX (p  lt  0.001). It showed significant decontamination of implant surfaces with complete elimination of anaerobic bacteria immediately after surgical procedure and three months later. Conclusion The results indicate that PDT can be used as an adjuvant therapy to surgery for decontamination of implant surface and surrounding peri-implant tissues within the treatment of peri-implantitis., Uvod Periimplantitis je inflamatorni proces koji zahvata meka tkiva i potpornu kost oko oseointegrisanog implantata. Eliminacija patogenih mikroorganizama i dekontaminacija implantne površine predstavlju najbitniji korak u postizanju stabilnih kliničkih rezultata. Fotodinamska terapija (FDT) predstavlja dodatni neinvazivni metod u terapiji bakterijskih infekcija. Cilj rada Cilj rada bila je procena kliničkih i mikrobioloških parametara nakon hirurške terapije periimplantitisa uz dodatnu primenu FDT. Metode rada Sva dijagnostikovana mesta periimplantitisa (n = 52) bila su podeljena u dve grupe: u studijskoj grupi, za dekontaminaciju implantne površine tokom hirurške procedure korišćena je FDT; u kontrolnoj grupi, za dekontaminaciju implantne površine korišćen je hlorheksidin u gelu (CHX). Klinički parametri praćeni su pre terapijske procedure i tri meseca posle terapije. Uzorci za mikrobiološku analizu uzimani su pre i tri meseca posle terapije, kao i tokom hirurške procedure, pre i posle dekontaminacije implantne površine. Za identifikaciju izolovanih anaeroba korišćen je sistem koji radi po principu biohemijske analize izolovanih mikrobioloških sojeva. Rezultati studije su pokazali da primenom FDT dolazi do znatne redukcije krvarenja na provokaciju u poređenju sa primenom CHX (p  lt  0,001). Primena FDT, kao pomoćnog terapijskog sredstva, omogućava potpunu eliminaciju anaerobnih bakterija sa implantne površine. Zaključak Rezultati pokazuju da FDT može da se koristi kao pomoćno terapijsko sredstvo za dekontaminaciju implantne površine i periimplantnog tkiva u okviru terapije periimplantitisa.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial, Procena efikasnosti fotodinamske terapije u terapiji periimplantitisa posle tri meseca - randomizirana kontrolisana klinička studija",
volume = "144",
number = "9-10",
pages = "478-484",
doi = "10.2298/sarh1610478r"
}

Rakašević, D., Lazić, Z., Rakonjac, B., Soldatović, I., Janković, S., Magić, M.,& Aleksić, Z.. (2016). Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 144(9-10), 478-484.
https://doi.org/10.2298/sarh1610478r

Rakašević D, Lazić Z, Rakonjac B, Soldatović I, Janković S, Magić M, Aleksić Z. Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial. in Srpski arhiv za celokupno lekarstvo. 2016;144(9-10):478-484.
doi:10.2298/sarh1610478r .

Rakašević, Dragana, Lazić, Zoran, Rakonjac, Bojan, Soldatović, Ivan, Janković, Saša, Magić, Marko, Aleksić, Zoran, "Efficiency of photodynamic therapy in the treatment of peri-implantitis: A three-month randomized controlled clinical trial" in Srpski arhiv za celokupno lekarstvo, 144, no. 9-10 (2016):478-484,
https://doi.org/10.2298/sarh1610478r . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Lazić, Zoran
AU  - Mišić, Tijana
AU  - Šćepanović, Miodrag
AU  - Todorović, Aleksandar
AU  - Thakare, Kaustubh
AU  - Janjić, Bojan
AU  - Vlahović, Zoran
AU  - Glišić, Mirko
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2081
AB  - Background/Aim. During drilling implant sites, mechanical energy is converted into thermal one resulting in transient rise in temperature of surrounding bone. The temperature of 47°C exeeding one minute impairs osseointegration, compromises mechanical properties of the local bone and could cause early implant failure. This in vitro study aimed to assess the effect of surgical drill guide and temperature of irrigans on thermal changes of the local bone during drilling implant sites, and to test the influence of irrigans temperature on the temperature of surgical drill guide. Methods. A total of 48 specimens obtained from bovine ribs were randomly allocated to four experimental conditions according to the 2 x 2 factorial design: drill guide (with or without) and saline (at 25°C or 5°C). Real-time infrared thermography was used as a method for temperature measurement. The primary outcome was bone temperature change during drilling implant sites measured at 3 osteotomy depths, whereas the second one was change in the temperature of the drill guide. Data were analyzed by Brunner and Langer nonparametric analysis and Wilcoxon test. Results. The effect of drill guide on the changes of bone temperature was significant at the entrance of osteotomy, whereas the effect of saline temperature was significant at all osteotomy levels (p  lt  0.001). No significant interaction was found (p > 0.05). Guided surgery and irrigation with saline at 25°C were associated with the highest bone temperature increase. Increase in drill guide temperature was significantly higher when saline at 25°C was used (p  lt  0.001). Conclusion. Guided implant site preparation generates higher temperature of the local bone than conventional drilling, not exceeding the threshold for thermal bone necrosis. Although saline at room temperature provides sufficient heat control during drilling, cooled saline is more effective regardless the use of surgical drill guide.
AB  - Uvod/Cilj. Tokom preparacije ležišta za implantat mehanička energija pretvara se u toplotnu, što dovodi do prolaznog povišenja temperature okolne kosti. Temperatura od 47°C tokom više od jednog minuta narušava oseointegraciju, mehaničke osobine lokalne kosti i može dovesti do ranog neuspeha implantata. Cilj ove in vitro studije bio je da se ispita uticaj hirurškog stenta i temperature irigansa na termičke promene u kosti tokom preparacije ležišta za implantat, kao i uticaj temperature irigansa na temperaturu hirurškog stenta. Metode. Ukupno 48 uzoraka dobijenih od goveđih rebara bilo je podeljeno metodom slučajnog izbora u četiri grupe prema 2 x 2 faktorskom dizajnu: prisustvo hirurškog stenta (da/ne) i temperatura fiziološkog rastvora (25°C/5°C). Temperatura je merena infracrvenom termografijom u realnom vremenu. Primarni ishod bio je promena temperature kosti tokom preparacije ležišta implantata merena na tri dubine ležišta, a sekundarni ishod promena temperature hirurškog stenta. Podaci su analizirani Bruner-Langer neparametrijskom analizom i Vilkoksonovim testom. Rezultati. Uticaj hirurškog stenta na promenutemperature kosti bio je značajan na ulazu u ležište za implantat, dok je uticaj temperature irigansa bio značajan na svim dubinama ležišta (p  lt  0,001). Međusobni uticaj ispitivanih faktora nije bio značajan (p > 0,05). Upotreba hirurškog stenta i ispiranje fiziološkim rastvorom temperature 25°C bili su praćeni najvišim porastom temperature kosti. Porast temperature hirurškog stenta bio je značajno viši kada je korišćeno ispiranje na temperaturi od 25°C (p  lt  0,001). Zaključak. Tokom kontrolisane preparacije ležišta za implantat došlo je do većeg zagrevanja kosti u poređenju sa standardnom preparacijom, ne premašujući temperaturu kritičnu za termičku nekrozu kosti. Iako ispiranje na sobnoj temperaturi obezbeđuje dovoljno hlađenja kosti tokom preparacije ležišta za implantat, ohlađeni rastvor za ispiranje je efikasniji bez obzira na primenu hirurškog stenta.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites: Thermographic analysis on bovine ribs
T1  - Uticaj hirurškog stenta i temperature irigansa na termičke promene u kosti tokom preparacije ležišta implantata - termografska analiza na goveđim rebrima
VL  - 73
IS  - 8
SP  - 744
EP  - 750
DO  - 10.2298/VSP141208041M
ER  - 

@article{
author = "Marković, Aleksa and Lazić, Zoran and Mišić, Tijana and Šćepanović, Miodrag and Todorović, Aleksandar and Thakare, Kaustubh and Janjić, Bojan and Vlahović, Zoran and Glišić, Mirko",
year = "2016",
abstract = "Background/Aim. During drilling implant sites, mechanical energy is converted into thermal one resulting in transient rise in temperature of surrounding bone. The temperature of 47°C exeeding one minute impairs osseointegration, compromises mechanical properties of the local bone and could cause early implant failure. This in vitro study aimed to assess the effect of surgical drill guide and temperature of irrigans on thermal changes of the local bone during drilling implant sites, and to test the influence of irrigans temperature on the temperature of surgical drill guide. Methods. A total of 48 specimens obtained from bovine ribs were randomly allocated to four experimental conditions according to the 2 x 2 factorial design: drill guide (with or without) and saline (at 25°C or 5°C). Real-time infrared thermography was used as a method for temperature measurement. The primary outcome was bone temperature change during drilling implant sites measured at 3 osteotomy depths, whereas the second one was change in the temperature of the drill guide. Data were analyzed by Brunner and Langer nonparametric analysis and Wilcoxon test. Results. The effect of drill guide on the changes of bone temperature was significant at the entrance of osteotomy, whereas the effect of saline temperature was significant at all osteotomy levels (p  lt  0.001). No significant interaction was found (p > 0.05). Guided surgery and irrigation with saline at 25°C were associated with the highest bone temperature increase. Increase in drill guide temperature was significantly higher when saline at 25°C was used (p  lt  0.001). Conclusion. Guided implant site preparation generates higher temperature of the local bone than conventional drilling, not exceeding the threshold for thermal bone necrosis. Although saline at room temperature provides sufficient heat control during drilling, cooled saline is more effective regardless the use of surgical drill guide., Uvod/Cilj. Tokom preparacije ležišta za implantat mehanička energija pretvara se u toplotnu, što dovodi do prolaznog povišenja temperature okolne kosti. Temperatura od 47°C tokom više od jednog minuta narušava oseointegraciju, mehaničke osobine lokalne kosti i može dovesti do ranog neuspeha implantata. Cilj ove in vitro studije bio je da se ispita uticaj hirurškog stenta i temperature irigansa na termičke promene u kosti tokom preparacije ležišta za implantat, kao i uticaj temperature irigansa na temperaturu hirurškog stenta. Metode. Ukupno 48 uzoraka dobijenih od goveđih rebara bilo je podeljeno metodom slučajnog izbora u četiri grupe prema 2 x 2 faktorskom dizajnu: prisustvo hirurškog stenta (da/ne) i temperatura fiziološkog rastvora (25°C/5°C). Temperatura je merena infracrvenom termografijom u realnom vremenu. Primarni ishod bio je promena temperature kosti tokom preparacije ležišta implantata merena na tri dubine ležišta, a sekundarni ishod promena temperature hirurškog stenta. Podaci su analizirani Bruner-Langer neparametrijskom analizom i Vilkoksonovim testom. Rezultati. Uticaj hirurškog stenta na promenutemperature kosti bio je značajan na ulazu u ležište za implantat, dok je uticaj temperature irigansa bio značajan na svim dubinama ležišta (p  lt  0,001). Međusobni uticaj ispitivanih faktora nije bio značajan (p > 0,05). Upotreba hirurškog stenta i ispiranje fiziološkim rastvorom temperature 25°C bili su praćeni najvišim porastom temperature kosti. Porast temperature hirurškog stenta bio je značajno viši kada je korišćeno ispiranje na temperaturi od 25°C (p  lt  0,001). Zaključak. Tokom kontrolisane preparacije ležišta za implantat došlo je do većeg zagrevanja kosti u poređenju sa standardnom preparacijom, ne premašujući temperaturu kritičnu za termičku nekrozu kosti. Iako ispiranje na sobnoj temperaturi obezbeđuje dovoljno hlađenja kosti tokom preparacije ležišta za implantat, ohlađeni rastvor za ispiranje je efikasniji bez obzira na primenu hirurškog stenta.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites: Thermographic analysis on bovine ribs, Uticaj hirurškog stenta i temperature irigansa na termičke promene u kosti tokom preparacije ležišta implantata - termografska analiza na goveđim rebrima",
volume = "73",
number = "8",
pages = "744-750",
doi = "10.2298/VSP141208041M"
}

Marković, A., Lazić, Z., Mišić, T., Šćepanović, M., Todorović, A., Thakare, K., Janjić, B., Vlahović, Z.,& Glišić, M.. (2016). Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites: Thermographic analysis on bovine ribs. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(8), 744-750.
https://doi.org/10.2298/VSP141208041M

Marković A, Lazić Z, Mišić T, Šćepanović M, Todorović A, Thakare K, Janjić B, Vlahović Z, Glišić M. Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites: Thermographic analysis on bovine ribs. in Vojnosanitetski pregled. 2016;73(8):744-750.
doi:10.2298/VSP141208041M .

Marković, Aleksa, Lazić, Zoran, Mišić, Tijana, Šćepanović, Miodrag, Todorović, Aleksandar, Thakare, Kaustubh, Janjić, Bojan, Vlahović, Zoran, Glišić, Mirko, "Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites: Thermographic analysis on bovine ribs" in Vojnosanitetski pregled, 73, no. 8 (2016):744-750,
https://doi.org/10.2298/VSP141208041M . .

TY  - JOUR
AU  - Dubovina, Dejan
AU  - Mihailović, Branko
AU  - Bukumirić, Zoran
AU  - Vlahović, Zoran
AU  - Miladinović, Milan
AU  - Miković, Nikola
AU  - Lazić, Zoran
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2076
AB  - Background/Aim. Alveolar osteitis (AO), also known as "dry socket", is relatively common post-extraction complication. It probably occurs due to excessive fibrinolytic activity in the coagulum and is characterized by intense pain sensations. The aim of this clinical study was to examine the role of hyaluronic acid and aminocaproic acid in the treatment of AO. Methods. The study included 60 patients with the clinical diagnosis of AO. All the patients were divided into two groups of 30 patients each according to the applied non-pharmacological measure: irrigation - irrigation of dry socket with sterile saline; curettage - careful curettage. Both of these groups were further divided into three subgroups regarding the applied treatment (hyaluronic acid; hyaluronic acid + aminocaproic acid; Alvogyl®, an anesthetic and antiseptic paste), each with 10 patients, according to the following protocol: 0.2 mL of hyaluronic acid in the form of a 0.8% gel; 2 mL of aminocaproic acid and hyaluronic acid; Alvogyl®. During each visit, scheduled for every two days until complete absence of painful sensations, the patients had the therapeutic method repeated as at the first examination. At each control visit the number of present symptoms and signs of AO was recorded, as well as the level of pain (measured with a visual analogue scale). Results. With the use of hyaluronic acid, with or without aminocaproic one, a statistically significantly faster reduction in pain sensations was achieved, along with the reduction in the number of symptoms and signs of AO compared to the use of Alvogyl®. Conclusion. Hyaluronic acid, applied alone or in combination with aminocaproic acid significantly reduces pain sensation, thus it can be successfully used in the treatment of AO.
AB  - Uvod/Cilj. Alveolitis je relativno česta postekstrakciona komplikacija. Nastaje, najverovatnije, usled izrazite fibrinolitičke aktivnosti u koagulumu, a karakteriše se pojavom intezivnog bola. Cilj ove kliničke studije bio je da se ispita mogućnost primene hijaluronske i aminokapronske kiseline u terapiji alveolitisa. Metode. Studija je uključila 60 pacijenata sa kliničkom dijagnozom alveolitisa. U odnosu na primenjenu nefarmakološku meru svi pacijenti su bili podeljeni u dve grupe sa po 30 pacijenata: ispiranje - ispiranje obolele alveole sterilnim fiziološkim rastvorom; kiretaža - pažljiva kiretaža. Obe ove grupe, u odnosu na primenjeni tretman [(hijaluronska kiselina, hijaluronska kiselina + aminokapronska kiselina, Alvogyl® (kombinacija anestetika i antiseptika u obliku paste)], bile su podeljene u tri podgrupe sa po 10 pacijenata po sledećem protokolu: 0,2 mL hijaluronske kiseline u obliku 0.8% gela; 2 mL aminokapronske kiseline i hijaluronske kiseline; Alvogyl®. Na kontrolnim pregledima, zakazanim na svaka dva dana do potpunog prestanka bolnih senzacija, pacijentima je ponavljana terapijska opcija sa prvog pregleda. Evidentiran je broj prisutnih simptoma i znakova alveolitisa kod pacijenata, kao i nivo bola (meren pomoću vizuelno-analogne skale). Rezultati. Primenom hijaluronske kiseline, sa ili bez aminokapronske kiseline, postignuto je statistički značajno brže sniženje bolnih senzacija kao i smanjenje broja prisutnih simptoma i znakova alveolitisa u odnosu na upotrebu Alvogyl®-a. Zaključak. Hijaluroska kiselina, samostalno ili u kombinaciji sa aminokapronskom kiselinom, značajno snižava bol, te se može uspešno primenjivati u terapiji alveolitisa.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis
T1  - Primena hijaluronske i aminokapronske kiseline u terapiji alveolitisa
VL  - 73
IS  - 11
SP  - 1010
EP  - 1015
DO  - 10.2298/VSP150304125D
ER  - 

@article{
author = "Dubovina, Dejan and Mihailović, Branko and Bukumirić, Zoran and Vlahović, Zoran and Miladinović, Milan and Miković, Nikola and Lazić, Zoran",
year = "2016",
abstract = "Background/Aim. Alveolar osteitis (AO), also known as "dry socket", is relatively common post-extraction complication. It probably occurs due to excessive fibrinolytic activity in the coagulum and is characterized by intense pain sensations. The aim of this clinical study was to examine the role of hyaluronic acid and aminocaproic acid in the treatment of AO. Methods. The study included 60 patients with the clinical diagnosis of AO. All the patients were divided into two groups of 30 patients each according to the applied non-pharmacological measure: irrigation - irrigation of dry socket with sterile saline; curettage - careful curettage. Both of these groups were further divided into three subgroups regarding the applied treatment (hyaluronic acid; hyaluronic acid + aminocaproic acid; Alvogyl®, an anesthetic and antiseptic paste), each with 10 patients, according to the following protocol: 0.2 mL of hyaluronic acid in the form of a 0.8% gel; 2 mL of aminocaproic acid and hyaluronic acid; Alvogyl®. During each visit, scheduled for every two days until complete absence of painful sensations, the patients had the therapeutic method repeated as at the first examination. At each control visit the number of present symptoms and signs of AO was recorded, as well as the level of pain (measured with a visual analogue scale). Results. With the use of hyaluronic acid, with or without aminocaproic one, a statistically significantly faster reduction in pain sensations was achieved, along with the reduction in the number of symptoms and signs of AO compared to the use of Alvogyl®. Conclusion. Hyaluronic acid, applied alone or in combination with aminocaproic acid significantly reduces pain sensation, thus it can be successfully used in the treatment of AO., Uvod/Cilj. Alveolitis je relativno česta postekstrakciona komplikacija. Nastaje, najverovatnije, usled izrazite fibrinolitičke aktivnosti u koagulumu, a karakteriše se pojavom intezivnog bola. Cilj ove kliničke studije bio je da se ispita mogućnost primene hijaluronske i aminokapronske kiseline u terapiji alveolitisa. Metode. Studija je uključila 60 pacijenata sa kliničkom dijagnozom alveolitisa. U odnosu na primenjenu nefarmakološku meru svi pacijenti su bili podeljeni u dve grupe sa po 30 pacijenata: ispiranje - ispiranje obolele alveole sterilnim fiziološkim rastvorom; kiretaža - pažljiva kiretaža. Obe ove grupe, u odnosu na primenjeni tretman [(hijaluronska kiselina, hijaluronska kiselina + aminokapronska kiselina, Alvogyl® (kombinacija anestetika i antiseptika u obliku paste)], bile su podeljene u tri podgrupe sa po 10 pacijenata po sledećem protokolu: 0,2 mL hijaluronske kiseline u obliku 0.8% gela; 2 mL aminokapronske kiseline i hijaluronske kiseline; Alvogyl®. Na kontrolnim pregledima, zakazanim na svaka dva dana do potpunog prestanka bolnih senzacija, pacijentima je ponavljana terapijska opcija sa prvog pregleda. Evidentiran je broj prisutnih simptoma i znakova alveolitisa kod pacijenata, kao i nivo bola (meren pomoću vizuelno-analogne skale). Rezultati. Primenom hijaluronske kiseline, sa ili bez aminokapronske kiseline, postignuto je statistički značajno brže sniženje bolnih senzacija kao i smanjenje broja prisutnih simptoma i znakova alveolitisa u odnosu na upotrebu Alvogyl®-a. Zaključak. Hijaluroska kiselina, samostalno ili u kombinaciji sa aminokapronskom kiselinom, značajno snižava bol, te se može uspešno primenjivati u terapiji alveolitisa.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis, Primena hijaluronske i aminokapronske kiseline u terapiji alveolitisa",
volume = "73",
number = "11",
pages = "1010-1015",
doi = "10.2298/VSP150304125D"
}

Dubovina, D., Mihailović, B., Bukumirić, Z., Vlahović, Z., Miladinović, M., Miković, N.,& Lazić, Z.. (2016). The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(11), 1010-1015.
https://doi.org/10.2298/VSP150304125D

Dubovina D, Mihailović B, Bukumirić Z, Vlahović Z, Miladinović M, Miković N, Lazić Z. The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis. in Vojnosanitetski pregled. 2016;73(11):1010-1015.
doi:10.2298/VSP150304125D .

Dubovina, Dejan, Mihailović, Branko, Bukumirić, Zoran, Vlahović, Zoran, Miladinović, Milan, Miković, Nikola, Lazić, Zoran, "The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis" in Vojnosanitetski pregled, 73, no. 11 (2016):1010-1015,
https://doi.org/10.2298/VSP150304125D . .

TY  - JOUR
AU  - Mandić, Borka
AU  - Lazić, Zoran
AU  - Marković, Aleksa
AU  - Mandić, Bojan
AU  - Mandić, Miška
AU  - Đinić, Ana
AU  - Miličić, Biljana
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2020
AB  - Background/Aim. Low-level laser therapy (LLLT) has been proven to stimulate bone repair, affecting cellular proliferation, differentiation and adhesion, and has shown a potential to reduce the healing time following implant placement. The aim of this clinical study was to investigate the influence of postoperative LLLT osseointegration and early success of self-tapping implants placed into low-density bone. Methods. Following the split-mouth design, self-tapping implants (n = 44) were inserted in the posterior maxilla of 12 patients. One jaw side randomly received LLLT (test group), while the other side was placebo (control group). For LLLT, a 637 nm gallium-aluminum-arsenide (GaAlAs) laser (Medicolaser 637, Technoline, Belgrade, Serbia) with an output power of 40 mW and continuous wave was used. Low-level laser treatment was performed immediately after the surgery and then repeated every day in the following 7 days. The total irradiation dose per treatment was 6.26 J/cm² per implant. The study outcomes were: implant stability, alkaline-phosphatase (ALP) activity and early implant success rate. The follow-up took 6 weeks. Results. Irradiated implants achieved a higher stability compared with controls during the entire follow-up and the difference reached significance in the 5th postoperative week (paired t-test, p = 0.030). The difference in ALP activ- ity between the groups was insignificant in any observation point (paired t-test, p > 0.05). The early implant success rate was 100%, regardless of LLLT usage. Conclusion. LLLT applied daily during the first postoperative week expressed no significant influence on the osseointegration of self- tapping implants placed into low density bone of the posterior maxilla. Placement of self-tapping macro-designed implants into low density bone could be a predictable therapeutic procedure with a high early success rate regardless of LLLT usage.
AB  - Uvod/Cilj. Terapija laserom male snage (TLMS) stimuliše reparatorne sposobnosti kosti utičući na ćelijsku proliferaciju, diferencijaciju i adheziju, i ima potencijal da skrati vreme zarastanja kosti nakon ugradnje implantata. Cilj ove kliničke studije bio je da se ispita uticaj postoperativne primene TLMS na oseointegraciju i rani uspeh ugradnje samourezujućih implantata u kost male gustine. Metode. Prateći split- mouth dizajn, samourezujući implantati (n = 44) ugrađeni su u posteriorne regije gornje vilice 12 pacijenata. Slučajnim izborom, jednoj od strana vilice je dodeljena TLMS (test grupa), dok je druga strana bila placebo (kontrolna grupa). Za TLMS korišćen je galijum-aluminijum-arsenid (GaAlAs) laser (Medicolaser 637, Technoline, Beograd, Srbija) talasne dužine 637 nm, snage 40 mW, neprekidnog režima rada. Tretman laserom male snage sprovodio se neposredno po ugradnji, a zatim svakodnevno, tokom narednih sedam dana. Ukupna zračna doza po tretmanu bila je 6,26 J/cm² po implantatu. Praćeni su stabilnost implantata, aktivnost alkalne fosfataze (ALP) i procenat rane uspešnosti implantatne terapije. Period praćenja bio je šest nedelja. Rezultati. Zračeni implantati imali su veću stabilnost u odnosu na kontrolne tokom celog perioda praćenja, a statistički značajno veća stabilnost bila je u petoj postoperativnoj nedelji (t-test za vezane uzorke, p = 0.030). Razlika u aktivnosti ALP između grupa nije bila statistički značajna ni u jednoj tački posmatranja (t-test za vezane uzorke, p > 0.05). Procenat rane uspešnosti terapije implantatima bio je 100%, bez obzira na primenjenu TLMS. Zaključak. Svakodnevna primena TLMS u prvoj postoperativnoj nedelji nije pokazala značajan uticaj na oseointegraciju samourezujućih implantata u kost male gustine bočne regije gornje vilice. Primena implantata samourezujućeg makrodizajna u kosti male gustine mogla bi predstavljati predvidljivu terapijsku proceduru sa visokim procentom rane uspešnosti, bez obzira na primenjenu TLMS.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Influence of postoperative low-level laser therapy on the osseointegration of self-tapping implants in the posterior maxilla: A 6-week split-mouth clinical study
T1  - Uticaj postoperativne terapije laserom male snage na oseointegraciju samourezujućih implantata u bočnoj regiji gornje vilice - šestonedeljna split-mouth klinička studija
VL  - 72
IS  - 3
SP  - 233
EP  - 240
DO  - 10.2298/vsp131202075m
ER  - 

@article{
author = "Mandić, Borka and Lazić, Zoran and Marković, Aleksa and Mandić, Bojan and Mandić, Miška and Đinić, Ana and Miličić, Biljana",
year = "2015",
abstract = "Background/Aim. Low-level laser therapy (LLLT) has been proven to stimulate bone repair, affecting cellular proliferation, differentiation and adhesion, and has shown a potential to reduce the healing time following implant placement. The aim of this clinical study was to investigate the influence of postoperative LLLT osseointegration and early success of self-tapping implants placed into low-density bone. Methods. Following the split-mouth design, self-tapping implants (n = 44) were inserted in the posterior maxilla of 12 patients. One jaw side randomly received LLLT (test group), while the other side was placebo (control group). For LLLT, a 637 nm gallium-aluminum-arsenide (GaAlAs) laser (Medicolaser 637, Technoline, Belgrade, Serbia) with an output power of 40 mW and continuous wave was used. Low-level laser treatment was performed immediately after the surgery and then repeated every day in the following 7 days. The total irradiation dose per treatment was 6.26 J/cm² per implant. The study outcomes were: implant stability, alkaline-phosphatase (ALP) activity and early implant success rate. The follow-up took 6 weeks. Results. Irradiated implants achieved a higher stability compared with controls during the entire follow-up and the difference reached significance in the 5th postoperative week (paired t-test, p = 0.030). The difference in ALP activ- ity between the groups was insignificant in any observation point (paired t-test, p > 0.05). The early implant success rate was 100%, regardless of LLLT usage. Conclusion. LLLT applied daily during the first postoperative week expressed no significant influence on the osseointegration of self- tapping implants placed into low density bone of the posterior maxilla. Placement of self-tapping macro-designed implants into low density bone could be a predictable therapeutic procedure with a high early success rate regardless of LLLT usage., Uvod/Cilj. Terapija laserom male snage (TLMS) stimuliše reparatorne sposobnosti kosti utičući na ćelijsku proliferaciju, diferencijaciju i adheziju, i ima potencijal da skrati vreme zarastanja kosti nakon ugradnje implantata. Cilj ove kliničke studije bio je da se ispita uticaj postoperativne primene TLMS na oseointegraciju i rani uspeh ugradnje samourezujućih implantata u kost male gustine. Metode. Prateći split- mouth dizajn, samourezujući implantati (n = 44) ugrađeni su u posteriorne regije gornje vilice 12 pacijenata. Slučajnim izborom, jednoj od strana vilice je dodeljena TLMS (test grupa), dok je druga strana bila placebo (kontrolna grupa). Za TLMS korišćen je galijum-aluminijum-arsenid (GaAlAs) laser (Medicolaser 637, Technoline, Beograd, Srbija) talasne dužine 637 nm, snage 40 mW, neprekidnog režima rada. Tretman laserom male snage sprovodio se neposredno po ugradnji, a zatim svakodnevno, tokom narednih sedam dana. Ukupna zračna doza po tretmanu bila je 6,26 J/cm² po implantatu. Praćeni su stabilnost implantata, aktivnost alkalne fosfataze (ALP) i procenat rane uspešnosti implantatne terapije. Period praćenja bio je šest nedelja. Rezultati. Zračeni implantati imali su veću stabilnost u odnosu na kontrolne tokom celog perioda praćenja, a statistički značajno veća stabilnost bila je u petoj postoperativnoj nedelji (t-test za vezane uzorke, p = 0.030). Razlika u aktivnosti ALP između grupa nije bila statistički značajna ni u jednoj tački posmatranja (t-test za vezane uzorke, p > 0.05). Procenat rane uspešnosti terapije implantatima bio je 100%, bez obzira na primenjenu TLMS. Zaključak. Svakodnevna primena TLMS u prvoj postoperativnoj nedelji nije pokazala značajan uticaj na oseointegraciju samourezujućih implantata u kost male gustine bočne regije gornje vilice. Primena implantata samourezujućeg makrodizajna u kosti male gustine mogla bi predstavljati predvidljivu terapijsku proceduru sa visokim procentom rane uspešnosti, bez obzira na primenjenu TLMS.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Influence of postoperative low-level laser therapy on the osseointegration of self-tapping implants in the posterior maxilla: A 6-week split-mouth clinical study, Uticaj postoperativne terapije laserom male snage na oseointegraciju samourezujućih implantata u bočnoj regiji gornje vilice - šestonedeljna split-mouth klinička studija",
volume = "72",
number = "3",
pages = "233-240",
doi = "10.2298/vsp131202075m"
}

Mandić, B., Lazić, Z., Marković, A., Mandić, B., Mandić, M., Đinić, A.,& Miličić, B.. (2015). Influence of postoperative low-level laser therapy on the osseointegration of self-tapping implants in the posterior maxilla: A 6-week split-mouth clinical study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(3), 233-240.
https://doi.org/10.2298/vsp131202075m

Mandić B, Lazić Z, Marković A, Mandić B, Mandić M, Đinić A, Miličić B. Influence of postoperative low-level laser therapy on the osseointegration of self-tapping implants in the posterior maxilla: A 6-week split-mouth clinical study. in Vojnosanitetski pregled. 2015;72(3):233-240.
doi:10.2298/vsp131202075m .

Mandić, Borka, Lazić, Zoran, Marković, Aleksa, Mandić, Bojan, Mandić, Miška, Đinić, Ana, Miličić, Biljana, "Influence of postoperative low-level laser therapy on the osseointegration of self-tapping implants in the posterior maxilla: A 6-week split-mouth clinical study" in Vojnosanitetski pregled, 72, no. 3 (2015):233-240,
https://doi.org/10.2298/vsp131202075m . .

TY  - JOUR
AU  - Lazić, Zoran
AU  - Golubović, Mileta
AU  - Marković, Aleksa
AU  - Šćepanović, Miodrag
AU  - Mišić, Tijana
AU  - Vlahović, Zoran
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1964
AB  - AimThe aim of this experimental study is to compare the effect of mini-incision flapless versus flap technique of implant placement on the amount of vascular structures and blood vessel elements in peri-implant soft tissue, using immunohistochemical analysis. MethodThe experiment was conducted on five domestic pigs. Each animal received six implants in mandible according to the split-mouth design. On one randomly chosen jaw side, mini-incision flapless surgery was performed, whereas on the opposite jaw side, flap was raised. After 3months of implant healing through submerged approach, the experimental animals were sacrificed and samples for immunohistochemical analyses were taken from the buccal side of peri-implant mucosa next to the neck of implants, from three levels. The study outcome was the presence of vascular structures and elements of the blood vessels in the peri-implant mucosa per microscopic field, estimated through ordinal scores from 0 to 2. Effects of surgical approach, site of implantation, and their interaction on vascular scores of peri-implant mucosa were assessed by Brunner and Langer nonparametric analysis of longitudinal data. ResultsStatistically significant effect of surgical approach on vascularity of peri-implant mucosa has been revealed in the second mucosal layer, where flapless approach provided higher vascularity compared with flap approach (P=0.002). In the remaining two layers, surgical approach did not affect mucosal vascularity significantly (layer 1: P=0.071; layer 3: P=0.433). ConclusionThe flapless surgical implant placement approach using mini-incision provides better vascularization of peri-implant mucosa after 3months of healing compared with flap surgery.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical Oral Implants Research
T1  - Immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs
VL  - 26
IS  - 7
SP  - 775
EP  - 779
DO  - 10.1111/clr.12337
ER  - 

@article{
author = "Lazić, Zoran and Golubović, Mileta and Marković, Aleksa and Šćepanović, Miodrag and Mišić, Tijana and Vlahović, Zoran",
year = "2015",
abstract = "AimThe aim of this experimental study is to compare the effect of mini-incision flapless versus flap technique of implant placement on the amount of vascular structures and blood vessel elements in peri-implant soft tissue, using immunohistochemical analysis. MethodThe experiment was conducted on five domestic pigs. Each animal received six implants in mandible according to the split-mouth design. On one randomly chosen jaw side, mini-incision flapless surgery was performed, whereas on the opposite jaw side, flap was raised. After 3months of implant healing through submerged approach, the experimental animals were sacrificed and samples for immunohistochemical analyses were taken from the buccal side of peri-implant mucosa next to the neck of implants, from three levels. The study outcome was the presence of vascular structures and elements of the blood vessels in the peri-implant mucosa per microscopic field, estimated through ordinal scores from 0 to 2. Effects of surgical approach, site of implantation, and their interaction on vascular scores of peri-implant mucosa were assessed by Brunner and Langer nonparametric analysis of longitudinal data. ResultsStatistically significant effect of surgical approach on vascularity of peri-implant mucosa has been revealed in the second mucosal layer, where flapless approach provided higher vascularity compared with flap approach (P=0.002). In the remaining two layers, surgical approach did not affect mucosal vascularity significantly (layer 1: P=0.071; layer 3: P=0.433). ConclusionThe flapless surgical implant placement approach using mini-incision provides better vascularization of peri-implant mucosa after 3months of healing compared with flap surgery.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs",
volume = "26",
number = "7",
pages = "775-779",
doi = "10.1111/clr.12337"
}

Lazić, Z., Golubović, M., Marković, A., Šćepanović, M., Mišić, T.,& Vlahović, Z.. (2015). Immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs. in Clinical Oral Implants Research
Wiley-Blackwell, Hoboken., 26(7), 775-779.
https://doi.org/10.1111/clr.12337

Lazić Z, Golubović M, Marković A, Šćepanović M, Mišić T, Vlahović Z. Immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs. in Clinical Oral Implants Research. 2015;26(7):775-779.
doi:10.1111/clr.12337 .

Lazić, Zoran, Golubović, Mileta, Marković, Aleksa, Šćepanović, Miodrag, Mišić, Tijana, Vlahović, Zoran, "Immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs" in Clinical Oral Implants Research, 26, no. 7 (2015):775-779,
https://doi.org/10.1111/clr.12337 . .

TY  - JOUR
AU  - Lazić, Zoran
AU  - Bubalo, Marija
AU  - Milović, Radomir
AU  - Matijević, Stevo
AU  - Magić, Marko
AU  - Đorđević, Igor
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1923
AB  - The properties of membranes for guided bone regeneration have been described by a number of authors. These involve biocompatibility, appropriate barrier features (mechanical prevention of soft tissue proliferation), tissue integration, immunologic neutrality, preservation of the space for new alveolar bone, and simplicity of application. Such membrane must hold out against the masticatory forces and tissue tension of the flap, and prevent the collapse of soft tissues and wound space reduction. The property of integration into the tissue guarantees wound stabilization and inhibits epithelial migration. The aim of this study was to compare and evaluate the influence of human resorbable demineralized membrane (RHDM) and bovine resorbable demineralized membrane (RBDM) on bone regeneration. The experiment, approved by the Ethical Committee, was performed on six dogs and conducted into three phases. Bone defects were created in all six dogs on the left side of the mandible, 8 weeks after extraction of the second, third and fourth premolar. One defect was covered with 200 μm thick RHDM, one with 200 μm thick RBDM, and the third defect was left empty (control defect). The pathohistological analysis was done two, four and six months after the surgery. In the third phase samples of bone tissue were taken and subjected to patohistological analysis. In all six dogs the defects treated with RHDM 200μm thick showed a higher level of bone regeneration in comparison with the defect treated with RBDM 200 μm thick and especially with the control defect. Our results demonstrated that the human membrane showed the least soft tissue ingrowth and promoted better bone formation at 6 months compared with a bovine one.
AB  - Svojstva membrane za vođenu koštanu regeneraciju opisali su brojni autori. Ona uključuju biokompatibilnost, odgovarajuću barijernu moć (mehaničko sprečavanje proliferacije mekog tkiva), tkivnu integraciju, imunološku inertnost, očuvanje prostora za novu alveolarnu kost i jednostavnost primene. Membrana mora da izdrži sile žvakanja i tkivne tenzije režnja, da spreči kolaps mekih tkiva i smanjenje prostora rane. Svojstvo tkivne integracije omogućava stabilizaciju rane i inhibiciju epitelne migracije. Cilj studije je bio da ispita uticaj humane resorptivne demineralizovane membrane (RHDM) i bovine resorptivne demineralizovane membrane (RBDM) na koštanu regeneraciju i da ih međusobno uporedi. Eksperimentalna studija rađena na 6 pasa rase nemački ovčar, sprovedena je u tri faze. U prvoj fazi izvršena je ekstrakcija drugog, trećeg i četvrtog premolara sa leve strane. Osam nedelja nakon ekstrakcije, formirana su tri defekta na levoj strani mandibule i prekrivena humanom membranom debljine 200μm, bovinom membranom debljine 200 μm a treći defekt je ostavljen prazan (kontrolni defekt). Patohistološka analiza rađena je nakon dva, četiri i šest meseci posle hirurške intervencije. U trećoj fazi uzorci koštanog tkiva podvrgnuti su patohistološkoj analizi. Kod svih 6 pasa, defekti prekriveni humanom membranom debljine 200 μm, pokazali su patohistološkom analizom znatno veći stepen koštane regeneracije u poređenju sa defektima prekrivenim sa bovinom membranom i naročito sa kontrolnim defektom. Naši rezultati su pokazali da je humana membrana pokazala najmanje prorastanje mekim tkivom i bolju koštanu regeneraciju nakon 6 meseci u poređenju sa bovinom.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Comparison of resorbable membranes for guided bone regeneration of human and bovine origin
T1  - Poređenje resorptivnih membrana u vođenoj koštanoj regeneraciji humanog i bovinog porekla
VL  - 64
IS  - 4
SP  - 477
EP  - 492
DO  - 10.2478/acve-2014-0045
ER  - 

@article{
author = "Lazić, Zoran and Bubalo, Marija and Milović, Radomir and Matijević, Stevo and Magić, Marko and Đorđević, Igor",
year = "2014",
abstract = "The properties of membranes for guided bone regeneration have been described by a number of authors. These involve biocompatibility, appropriate barrier features (mechanical prevention of soft tissue proliferation), tissue integration, immunologic neutrality, preservation of the space for new alveolar bone, and simplicity of application. Such membrane must hold out against the masticatory forces and tissue tension of the flap, and prevent the collapse of soft tissues and wound space reduction. The property of integration into the tissue guarantees wound stabilization and inhibits epithelial migration. The aim of this study was to compare and evaluate the influence of human resorbable demineralized membrane (RHDM) and bovine resorbable demineralized membrane (RBDM) on bone regeneration. The experiment, approved by the Ethical Committee, was performed on six dogs and conducted into three phases. Bone defects were created in all six dogs on the left side of the mandible, 8 weeks after extraction of the second, third and fourth premolar. One defect was covered with 200 μm thick RHDM, one with 200 μm thick RBDM, and the third defect was left empty (control defect). The pathohistological analysis was done two, four and six months after the surgery. In the third phase samples of bone tissue were taken and subjected to patohistological analysis. In all six dogs the defects treated with RHDM 200μm thick showed a higher level of bone regeneration in comparison with the defect treated with RBDM 200 μm thick and especially with the control defect. Our results demonstrated that the human membrane showed the least soft tissue ingrowth and promoted better bone formation at 6 months compared with a bovine one., Svojstva membrane za vođenu koštanu regeneraciju opisali su brojni autori. Ona uključuju biokompatibilnost, odgovarajuću barijernu moć (mehaničko sprečavanje proliferacije mekog tkiva), tkivnu integraciju, imunološku inertnost, očuvanje prostora za novu alveolarnu kost i jednostavnost primene. Membrana mora da izdrži sile žvakanja i tkivne tenzije režnja, da spreči kolaps mekih tkiva i smanjenje prostora rane. Svojstvo tkivne integracije omogućava stabilizaciju rane i inhibiciju epitelne migracije. Cilj studije je bio da ispita uticaj humane resorptivne demineralizovane membrane (RHDM) i bovine resorptivne demineralizovane membrane (RBDM) na koštanu regeneraciju i da ih međusobno uporedi. Eksperimentalna studija rađena na 6 pasa rase nemački ovčar, sprovedena je u tri faze. U prvoj fazi izvršena je ekstrakcija drugog, trećeg i četvrtog premolara sa leve strane. Osam nedelja nakon ekstrakcije, formirana su tri defekta na levoj strani mandibule i prekrivena humanom membranom debljine 200μm, bovinom membranom debljine 200 μm a treći defekt je ostavljen prazan (kontrolni defekt). Patohistološka analiza rađena je nakon dva, četiri i šest meseci posle hirurške intervencije. U trećoj fazi uzorci koštanog tkiva podvrgnuti su patohistološkoj analizi. Kod svih 6 pasa, defekti prekriveni humanom membranom debljine 200 μm, pokazali su patohistološkom analizom znatno veći stepen koštane regeneracije u poređenju sa defektima prekrivenim sa bovinom membranom i naročito sa kontrolnim defektom. Naši rezultati su pokazali da je humana membrana pokazala najmanje prorastanje mekim tkivom i bolju koštanu regeneraciju nakon 6 meseci u poređenju sa bovinom.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Comparison of resorbable membranes for guided bone regeneration of human and bovine origin, Poređenje resorptivnih membrana u vođenoj koštanoj regeneraciji humanog i bovinog porekla",
volume = "64",
number = "4",
pages = "477-492",
doi = "10.2478/acve-2014-0045"
}

Lazić, Z., Bubalo, M., Milović, R., Matijević, S., Magić, M.,& Đorđević, I.. (2014). Comparison of resorbable membranes for guided bone regeneration of human and bovine origin. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 64(4), 477-492.
https://doi.org/10.2478/acve-2014-0045

Lazić Z, Bubalo M, Milović R, Matijević S, Magić M, Đorđević I. Comparison of resorbable membranes for guided bone regeneration of human and bovine origin. in Acta veterinaria. 2014;64(4):477-492.
doi:10.2478/acve-2014-0045 .

Lazić, Zoran, Bubalo, Marija, Milović, Radomir, Matijević, Stevo, Magić, Marko, Đorđević, Igor, "Comparison of resorbable membranes for guided bone regeneration of human and bovine origin" in Acta veterinaria, 64, no. 4 (2014):477-492,
https://doi.org/10.2478/acve-2014-0045 . .

TY  - JOUR
AU  - Delgado-Ruiz, Rafael
AU  - Marković, Aleksa
AU  - Calvo Guirado, Jose Luis
AU  - Lazić, Zoran
AU  - Piattelli, Adriano
AU  - Boticelli, Daniele
AU  - Maté-Sánchez, José Eduardo
AU  - Negri, Bruno
AU  - Ramírez-Fernández, María Piedad
AU  - Mišić, Tijana
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1900
AB  - Background/Aim. The modification of implant surfaces could affect mechanical implant stability as well as dynamics and quality of peri-implant bone healing. The aim of this 3-month experimental study in dogs was to investigate implant stability, marginal bone levels and bone tissue response to zirconia dental implants with two laser-micro-grooved intraosseous surfaces in comparison with nongrooved sandblasted zirconia and sandblasted, high-temperature etched titanium implants. Methods. Implant surface characterization was performed using optical interferometric profilometry and energy dispersive X-ray spectroscopy. A total of 96 implants (4 mm in diameter and 10 mm in length) were inserted randomly in both sides of the lower jaw of 12 Fox Hound dogs divided into groups of 24 each: the control (titanium), the group A (sandblasted zirconia), the group B (sandblasted zirconia plus microgrooved neck) and the group C (sandblasted zirconia plus all microgrooved). All the implants were immediately loaded. Insertion torque, periotest values, radiographic crestal bone level and removal torque were recorded during the 3-month follow-up. Qualitative scanning electon microscope (SEM) analysis of the bone-implant interfaces of each group was performed. Results. Insertion torque values were higher in the group C and control implants (p  lt  0.05). Periotest values increased in all the periods in proportion to the extent of microgrooving as follows: the group C > the control > the group B > the group A (p  lt  0.05). Radiographic measurements showed minimal crestal bone loss at 3 months for microgrooved zirconia implants (groups C and B) and control implants compared with the group A implants (p  lt  0.05). The removal torque values increased with time for all the groups as follows: the group C > the control > the group B > the group A (p  lt  0.05). SEM showed that implant surfaces of the groups B and C had an extra bone growth inside the microgrooves that corresponded to the shape and direction of the microgrooves. Conclusion. The addition of microgrooves to the entire intraosseous surface of zirconia dental implants enhances primary and secondary implant stability, promotes bone tissue in growth and preserves crestal bone levels.
AB  - Uvod/Cilj. Modifikacija površine implantata može uticati na njegovu mehaničku stabilnost kao i na dinamiku i kvalitet periimplantatnog koštanog zarastanja. Cilj ove tromesečne eksperimentalne studije na psima bio je da se ispita stabilnost implantata, nivo marginalne kosti i odgovor koštanog tkiva na cirkonijum endoosealne implantate sa dve intraosealne površine mikrostrukturirane laserom u poređenju sa peskiranim cirkonijum implantatima čija površina nije mikrostrukturirana kao i sa titanijum implantatima čije su površine peskirane i nagrižene visokom temperaturom. Metode. Karakterizacija površine implantata učinjena je optičkom interferometrijskom profilometrijom i analizom energetskog spektra pri difrakciji X-zračenja. Ukupno 96 implantata (prečnika 4 mm i dužine 10 mm) ugrađeno je nasumično i obostrano u donju vilicu kod 12 pasa (lisičara) i podeljeno u četiri grupe po 24: kontrolna (titanijum implantati); grupa A (peskirani cirkonijum implantati); grupa B (peskirani cirkonijum implantati sa mikrokanalima u koronarnoj trećini); grupa C (peskirani cirkonijum implantati sa mikrokanalima duž cele površine). Svi implantati su odmah opterećeni. Meren je obrtni momenat pri ugradnji implantata, vrednosti periotesta, radiografski nivo marginalne kosti i obrtni moment za uklanjanje implantata tokom tromesečnog perioda praćenja. Međuspoj kosti i implantata iz svake grupe ispitivan je kvalitativnom skenirajućom elektronskom mikroskopijom (SEM). Rezultati. Veći obrtni momenat zabeležen je pri ugradnji implantata kod grupe C i kontrolne grupe (p  lt  0,05). U ispitivanom vremenskom periodu, vrednosti periotesta uvećavale su se srazmerno obimu mikrostrukturiranja površine i to: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Radiografskom analizom utvrđen je minimalni gubitak marginalne kosti u trećem mesecu praćenja oko cirkonijum implantata sa mikrokanalima (grupa B i C) i kontrola u poređenju sa implantatima grupe A (p  lt  0,05). Vrednosti obrtnog momenta za uklanjanje implantata vremenom su se uvećavale u svim grupama na sledeći način: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Kod implantatnih površina grupa B i C, SEM je pokazala dodatni rast koštanog tkiva unutar mikrokanala koji odgovara njihovom obliku i pravcu. Zaključak. Formiranje mikrokanala duž cele intraosealne površine cirkonijum endoosealnih implantata povećava primarnu i sekundarnu implantatnu stabilnost, podstiče urastanje koštanog tkiva i održava nivo marginalne kosti.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs
T1  - Implantatna stabilnost i nivo marginalne kosti kod cirkonijum endoosealnih implantata sa mikrostrukturiranom površinom - tromesečna eksperimentalna studija na psima
VL  - 71
IS  - 5
SP  - 451
EP  - 461
DO  - 10.2298/VSP121003034D
ER  - 

@article{
author = "Delgado-Ruiz, Rafael and Marković, Aleksa and Calvo Guirado, Jose Luis and Lazić, Zoran and Piattelli, Adriano and Boticelli, Daniele and Maté-Sánchez, José Eduardo and Negri, Bruno and Ramírez-Fernández, María Piedad and Mišić, Tijana",
year = "2014",
abstract = "Background/Aim. The modification of implant surfaces could affect mechanical implant stability as well as dynamics and quality of peri-implant bone healing. The aim of this 3-month experimental study in dogs was to investigate implant stability, marginal bone levels and bone tissue response to zirconia dental implants with two laser-micro-grooved intraosseous surfaces in comparison with nongrooved sandblasted zirconia and sandblasted, high-temperature etched titanium implants. Methods. Implant surface characterization was performed using optical interferometric profilometry and energy dispersive X-ray spectroscopy. A total of 96 implants (4 mm in diameter and 10 mm in length) were inserted randomly in both sides of the lower jaw of 12 Fox Hound dogs divided into groups of 24 each: the control (titanium), the group A (sandblasted zirconia), the group B (sandblasted zirconia plus microgrooved neck) and the group C (sandblasted zirconia plus all microgrooved). All the implants were immediately loaded. Insertion torque, periotest values, radiographic crestal bone level and removal torque were recorded during the 3-month follow-up. Qualitative scanning electon microscope (SEM) analysis of the bone-implant interfaces of each group was performed. Results. Insertion torque values were higher in the group C and control implants (p  lt  0.05). Periotest values increased in all the periods in proportion to the extent of microgrooving as follows: the group C > the control > the group B > the group A (p  lt  0.05). Radiographic measurements showed minimal crestal bone loss at 3 months for microgrooved zirconia implants (groups C and B) and control implants compared with the group A implants (p  lt  0.05). The removal torque values increased with time for all the groups as follows: the group C > the control > the group B > the group A (p  lt  0.05). SEM showed that implant surfaces of the groups B and C had an extra bone growth inside the microgrooves that corresponded to the shape and direction of the microgrooves. Conclusion. The addition of microgrooves to the entire intraosseous surface of zirconia dental implants enhances primary and secondary implant stability, promotes bone tissue in growth and preserves crestal bone levels., Uvod/Cilj. Modifikacija površine implantata može uticati na njegovu mehaničku stabilnost kao i na dinamiku i kvalitet periimplantatnog koštanog zarastanja. Cilj ove tromesečne eksperimentalne studije na psima bio je da se ispita stabilnost implantata, nivo marginalne kosti i odgovor koštanog tkiva na cirkonijum endoosealne implantate sa dve intraosealne površine mikrostrukturirane laserom u poređenju sa peskiranim cirkonijum implantatima čija površina nije mikrostrukturirana kao i sa titanijum implantatima čije su površine peskirane i nagrižene visokom temperaturom. Metode. Karakterizacija površine implantata učinjena je optičkom interferometrijskom profilometrijom i analizom energetskog spektra pri difrakciji X-zračenja. Ukupno 96 implantata (prečnika 4 mm i dužine 10 mm) ugrađeno je nasumično i obostrano u donju vilicu kod 12 pasa (lisičara) i podeljeno u četiri grupe po 24: kontrolna (titanijum implantati); grupa A (peskirani cirkonijum implantati); grupa B (peskirani cirkonijum implantati sa mikrokanalima u koronarnoj trećini); grupa C (peskirani cirkonijum implantati sa mikrokanalima duž cele površine). Svi implantati su odmah opterećeni. Meren je obrtni momenat pri ugradnji implantata, vrednosti periotesta, radiografski nivo marginalne kosti i obrtni moment za uklanjanje implantata tokom tromesečnog perioda praćenja. Međuspoj kosti i implantata iz svake grupe ispitivan je kvalitativnom skenirajućom elektronskom mikroskopijom (SEM). Rezultati. Veći obrtni momenat zabeležen je pri ugradnji implantata kod grupe C i kontrolne grupe (p  lt  0,05). U ispitivanom vremenskom periodu, vrednosti periotesta uvećavale su se srazmerno obimu mikrostrukturiranja površine i to: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Radiografskom analizom utvrđen je minimalni gubitak marginalne kosti u trećem mesecu praćenja oko cirkonijum implantata sa mikrokanalima (grupa B i C) i kontrola u poređenju sa implantatima grupe A (p  lt  0,05). Vrednosti obrtnog momenta za uklanjanje implantata vremenom su se uvećavale u svim grupama na sledeći način: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Kod implantatnih površina grupa B i C, SEM je pokazala dodatni rast koštanog tkiva unutar mikrokanala koji odgovara njihovom obliku i pravcu. Zaključak. Formiranje mikrokanala duž cele intraosealne površine cirkonijum endoosealnih implantata povećava primarnu i sekundarnu implantatnu stabilnost, podstiče urastanje koštanog tkiva i održava nivo marginalne kosti.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs, Implantatna stabilnost i nivo marginalne kosti kod cirkonijum endoosealnih implantata sa mikrostrukturiranom površinom - tromesečna eksperimentalna studija na psima",
volume = "71",
number = "5",
pages = "451-461",
doi = "10.2298/VSP121003034D"
}

Delgado-Ruiz, R., Marković, A., Calvo Guirado, J. L., Lazić, Z., Piattelli, A., Boticelli, D., Maté-Sánchez, J. E., Negri, B., Ramírez-Fernández, M. P.,& Mišić, T.. (2014). Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(5), 451-461.
https://doi.org/10.2298/VSP121003034D

Delgado-Ruiz R, Marković A, Calvo Guirado JL, Lazić Z, Piattelli A, Boticelli D, Maté-Sánchez JE, Negri B, Ramírez-Fernández MP, Mišić T. Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs. in Vojnosanitetski pregled. 2014;71(5):451-461.
doi:10.2298/VSP121003034D .

Delgado-Ruiz, Rafael, Marković, Aleksa, Calvo Guirado, Jose Luis, Lazić, Zoran, Piattelli, Adriano, Boticelli, Daniele, Maté-Sánchez, José Eduardo, Negri, Bruno, Ramírez-Fernández, María Piedad, Mišić, Tijana, "Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs" in Vojnosanitetski pregled, 71, no. 5 (2014):451-461,
https://doi.org/10.2298/VSP121003034D . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Luis Calvo-Guirado, Jose
AU  - Lazić, Zoran
AU  - Gomez-Moreno, Gerardo
AU  - Ćalasan, Dejan
AU  - Guardia, Javier
AU  - Čolić, Snježana
AU  - Aguilar-Salvatierra, Antonio
AU  - Gačić, Bojan
AU  - Delgado-Ruiz, Rafael
AU  - Janjić, Bojan
AU  - Mišić, Tijana
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1816
AB  - Purpose: The aim of this study was to investigate the relationship between surgical techniques and implant macro-design (self-tapping/non-self-tapping) for the optimization of implant stability in the low-density bone present in the posterior maxilla using resonance frequency analysis (RFA). Materials and Methods: A total of 102 implants were studied. Fifty-six self-tapping BlueSkyBredent (R) (Bredent GmbH &, Senden, Germany) and 56 non-self-tapping Standard Plus Straumann (R) (Institut Straumann AG (R), Waldenburg, Switzerland) were placed in the posterior segment of the maxilla. Implants of both types were placed in sites prepared with either lateral bone-condensing or with bone-drilling techniques. Implant stability measurements were performed using RFA immediately after implant placement and weekly during a 12-week follow-up period. Results: Both types of implants placed after bone condensing achieved significantly higher stability immediately after surgery, as well as during the entire 12-week observation period compared with those placed following bone drilling. After bone condensation, there were no significant differences in primary stability or in implant stability after the first week between both implant types. From 2 to 12 postoperative weeks, significantly higher stability was shown by self-tapping implants. After bone drilling, self-tapping implants achieved significantly higher stability than non-self-tapping implants during the entire follow-up period. Conclusions: The outcomes of the present study indicate that bone drilling is not an effective technique for improving implant stability and, following this technique, the use of self-tapping implants is highly recommended. Implant stability optimization in the soft bone can be achieved by lateral bone-condensing technique, regardless of implant macro-design.
PB  - Wiley, Hoboken
T2  - Clinical Implant Dentistry & Related Research
T1  - Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study
VL  - 15
IS  - 3
SP  - 341
EP  - 349
DO  - 10.1111/j.1708-8208.2011.00415.x
ER  - 

@article{
author = "Marković, Aleksa and Luis Calvo-Guirado, Jose and Lazić, Zoran and Gomez-Moreno, Gerardo and Ćalasan, Dejan and Guardia, Javier and Čolić, Snježana and Aguilar-Salvatierra, Antonio and Gačić, Bojan and Delgado-Ruiz, Rafael and Janjić, Bojan and Mišić, Tijana",
year = "2013",
abstract = "Purpose: The aim of this study was to investigate the relationship between surgical techniques and implant macro-design (self-tapping/non-self-tapping) for the optimization of implant stability in the low-density bone present in the posterior maxilla using resonance frequency analysis (RFA). Materials and Methods: A total of 102 implants were studied. Fifty-six self-tapping BlueSkyBredent (R) (Bredent GmbH &, Senden, Germany) and 56 non-self-tapping Standard Plus Straumann (R) (Institut Straumann AG (R), Waldenburg, Switzerland) were placed in the posterior segment of the maxilla. Implants of both types were placed in sites prepared with either lateral bone-condensing or with bone-drilling techniques. Implant stability measurements were performed using RFA immediately after implant placement and weekly during a 12-week follow-up period. Results: Both types of implants placed after bone condensing achieved significantly higher stability immediately after surgery, as well as during the entire 12-week observation period compared with those placed following bone drilling. After bone condensation, there were no significant differences in primary stability or in implant stability after the first week between both implant types. From 2 to 12 postoperative weeks, significantly higher stability was shown by self-tapping implants. After bone drilling, self-tapping implants achieved significantly higher stability than non-self-tapping implants during the entire follow-up period. Conclusions: The outcomes of the present study indicate that bone drilling is not an effective technique for improving implant stability and, following this technique, the use of self-tapping implants is highly recommended. Implant stability optimization in the soft bone can be achieved by lateral bone-condensing technique, regardless of implant macro-design.",
publisher = "Wiley, Hoboken",
journal = "Clinical Implant Dentistry & Related Research",
title = "Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study",
volume = "15",
number = "3",
pages = "341-349",
doi = "10.1111/j.1708-8208.2011.00415.x"
}

Marković, A., Luis Calvo-Guirado, J., Lazić, Z., Gomez-Moreno, G., Ćalasan, D., Guardia, J., Čolić, S., Aguilar-Salvatierra, A., Gačić, B., Delgado-Ruiz, R., Janjić, B.,& Mišić, T.. (2013). Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study. in Clinical Implant Dentistry & Related Research
Wiley, Hoboken., 15(3), 341-349.
https://doi.org/10.1111/j.1708-8208.2011.00415.x

Marković A, Luis Calvo-Guirado J, Lazić Z, Gomez-Moreno G, Ćalasan D, Guardia J, Čolić S, Aguilar-Salvatierra A, Gačić B, Delgado-Ruiz R, Janjić B, Mišić T. Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study. in Clinical Implant Dentistry & Related Research. 2013;15(3):341-349.
doi:10.1111/j.1708-8208.2011.00415.x .

Marković, Aleksa, Luis Calvo-Guirado, Jose, Lazić, Zoran, Gomez-Moreno, Gerardo, Ćalasan, Dejan, Guardia, Javier, Čolić, Snježana, Aguilar-Salvatierra, Antonio, Gačić, Bojan, Delgado-Ruiz, Rafael, Janjić, Bojan, Mišić, Tijana, "Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study" in Clinical Implant Dentistry & Related Research, 15, no. 3 (2013):341-349,
https://doi.org/10.1111/j.1708-8208.2011.00415.x . .

TY  - JOUR
AU  - Jovičić, Bojan
AU  - Lazić, Zoran
AU  - Nedić, Milica
AU  - Matijević, Stevo
AU  - Špadijer-Gostović, Aleksandra
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1781
AB  - Background/Aim. Gingival recession progression in clinical practaice has influenced the development of various surgical procedures and techniques for solving esthetic imperfections and subjective difficulties coused by gingival recession. The aim of this study was to verify efficacy of surgical procedures and to compare both of surgical procedures through the keratinized tissue width. Methods. The study included 20 teeth with gingival recesion, Müller class I and II. Ten teeth with gingival recession were treated with connective tissue autotransplants with periosteum in combination with coronary guided surgical flap (CTG group). On the contralateral side 10 teeth with gingival recession were treated with the same surgical procedures but in combination with platelet-rich plasma (CTGPRP group). We measured the keratinized tissue width. For statistical significance we used the Student's t-test. Results. The study reveled a statistical significance in reducing vertical deepress of recession by both used treatments. Root deepness in CTG and CTG-PRP group was 90% and 93.5%, respectively. With both surgical techniques we achieved larger zone of keratinized gingiva but with a wide zone of keratinized tissue in CTG - the PRP group. Conclusion. The concept regeneration technique with PRP and with the stimulating influence of platele activated growth factors results in the regeneration of deep periodontal tissue as an important prerequisite for the successful treatment of gingival recession.
AB  - Uvod/Cilj. Sve veća zastupljenost gingivalnih recesija u svakodnevnoj kliničkoj praksi uslovila je zahteve za što efikasnijim rekonstruktivnim hirurškim procedurama, u cilju rešavanja estetskih nedostataka i subjektivnih tegoba usled povlačenja gingive. Cilj rada bio je da se uporedi efikasnost lečenja autotransplantatom vezivnog tkiva (ATVT) sa periostom i plazme obogaćene trombocitima (PRP) sa ATVT sa periostom, ali bez PRP, na širinu keratinizirane gingive. Metode. Studijama je bilo obuhvaćeno 20 zuba sa recesijama gingive klase I i II prema Mülleru. U toku terapije 10 recesija lečeno je ATVT sa periostom u kombinaciji sa koronarno pomerenim režnjima (ATVT grupa). Na kontralateralnoj strani, isti broj recesija lečen je ATVT uz koronarno pomeren režanj i uz primenu PRP (PRP + ATVT grupa). Od kliničkih parametara praćena je širina keratinizovane gingive kao pokazatelj pokrenutih regenerativnih procesa. U statističkoj obradi rezultata korišćen je Studentov t-test. Rezultati. Analizom kliničkih parametara ustanovljeno je statistički značajno proširenje zone keratinizirane gingive, što je od izuzetnog značaja za regeneraciju s tim što je proširenje bilo izraženije u ATVT + PRP grupi. Procentualno gledano, prekrivenost korena u ATVT grupi iznosila je 90%, a u ATVT + PRP grupi 93,5%. Zaključak. Primenom koncepta aktivne regeneracije odnosno primenom PRP i stimulativnim dejstvom aktiviranih faktora rasta iz trombocita, postiže se regeneracija dubljeg periodontalnog tkiva što je bitan preduslov za uspešno zbrinjavanje recesije gingive.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Therapeutic efficacy of connective tissue autotransplants with periosteum and platelet rich plasma in the management of gingival recession
T1  - Terapijski efekat plazme obogaćene trombocitima i autotransplantata vezivnog tkiva sa periostom u zbrinjavanju gingivalnih recesija
VL  - 70
IS  - 7
SP  - 664
EP  - 669
DO  - 10.2298/VSP1307664J
ER  - 

@article{
author = "Jovičić, Bojan and Lazić, Zoran and Nedić, Milica and Matijević, Stevo and Špadijer-Gostović, Aleksandra",
year = "2013",
abstract = "Background/Aim. Gingival recession progression in clinical practaice has influenced the development of various surgical procedures and techniques for solving esthetic imperfections and subjective difficulties coused by gingival recession. The aim of this study was to verify efficacy of surgical procedures and to compare both of surgical procedures through the keratinized tissue width. Methods. The study included 20 teeth with gingival recesion, Müller class I and II. Ten teeth with gingival recession were treated with connective tissue autotransplants with periosteum in combination with coronary guided surgical flap (CTG group). On the contralateral side 10 teeth with gingival recession were treated with the same surgical procedures but in combination with platelet-rich plasma (CTGPRP group). We measured the keratinized tissue width. For statistical significance we used the Student's t-test. Results. The study reveled a statistical significance in reducing vertical deepress of recession by both used treatments. Root deepness in CTG and CTG-PRP group was 90% and 93.5%, respectively. With both surgical techniques we achieved larger zone of keratinized gingiva but with a wide zone of keratinized tissue in CTG - the PRP group. Conclusion. The concept regeneration technique with PRP and with the stimulating influence of platele activated growth factors results in the regeneration of deep periodontal tissue as an important prerequisite for the successful treatment of gingival recession., Uvod/Cilj. Sve veća zastupljenost gingivalnih recesija u svakodnevnoj kliničkoj praksi uslovila je zahteve za što efikasnijim rekonstruktivnim hirurškim procedurama, u cilju rešavanja estetskih nedostataka i subjektivnih tegoba usled povlačenja gingive. Cilj rada bio je da se uporedi efikasnost lečenja autotransplantatom vezivnog tkiva (ATVT) sa periostom i plazme obogaćene trombocitima (PRP) sa ATVT sa periostom, ali bez PRP, na širinu keratinizirane gingive. Metode. Studijama je bilo obuhvaćeno 20 zuba sa recesijama gingive klase I i II prema Mülleru. U toku terapije 10 recesija lečeno je ATVT sa periostom u kombinaciji sa koronarno pomerenim režnjima (ATVT grupa). Na kontralateralnoj strani, isti broj recesija lečen je ATVT uz koronarno pomeren režanj i uz primenu PRP (PRP + ATVT grupa). Od kliničkih parametara praćena je širina keratinizovane gingive kao pokazatelj pokrenutih regenerativnih procesa. U statističkoj obradi rezultata korišćen je Studentov t-test. Rezultati. Analizom kliničkih parametara ustanovljeno je statistički značajno proširenje zone keratinizirane gingive, što je od izuzetnog značaja za regeneraciju s tim što je proširenje bilo izraženije u ATVT + PRP grupi. Procentualno gledano, prekrivenost korena u ATVT grupi iznosila je 90%, a u ATVT + PRP grupi 93,5%. Zaključak. Primenom koncepta aktivne regeneracije odnosno primenom PRP i stimulativnim dejstvom aktiviranih faktora rasta iz trombocita, postiže se regeneracija dubljeg periodontalnog tkiva što je bitan preduslov za uspešno zbrinjavanje recesije gingive.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Therapeutic efficacy of connective tissue autotransplants with periosteum and platelet rich plasma in the management of gingival recession, Terapijski efekat plazme obogaćene trombocitima i autotransplantata vezivnog tkiva sa periostom u zbrinjavanju gingivalnih recesija",
volume = "70",
number = "7",
pages = "664-669",
doi = "10.2298/VSP1307664J"
}

Jovičić, B., Lazić, Z., Nedić, M., Matijević, S.,& Špadijer-Gostović, A.. (2013). Therapeutic efficacy of connective tissue autotransplants with periosteum and platelet rich plasma in the management of gingival recession. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 70(7), 664-669.
https://doi.org/10.2298/VSP1307664J

Jovičić B, Lazić Z, Nedić M, Matijević S, Špadijer-Gostović A. Therapeutic efficacy of connective tissue autotransplants with periosteum and platelet rich plasma in the management of gingival recession. in Vojnosanitetski pregled. 2013;70(7):664-669.
doi:10.2298/VSP1307664J .

Jovičić, Bojan, Lazić, Zoran, Nedić, Milica, Matijević, Stevo, Špadijer-Gostović, Aleksandra, "Therapeutic efficacy of connective tissue autotransplants with periosteum and platelet rich plasma in the management of gingival recession" in Vojnosanitetski pregled, 70, no. 7 (2013):664-669,
https://doi.org/10.2298/VSP1307664J . .

TY  - JOUR
AU  - Mirković, Nemanja
AU  - Špadijer-Gostović, Aleksandra
AU  - Lazić, Zoran
AU  - Trifković, Branka
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1719
AB  - Background/Aim. Fracture toughness determines functional crown strenght and prevents damages on ceramics during mastication. There is a lack of relevant literature data about fracture toughness of crowns made by feather-edge preparation. Mechanical testing of ceramic samples is supposed to show if feather-edge tooth preparation is a successful method for making ceramic crowns without any risk of reduction of their mechanical properties. This research was done to establish effects of feather-edge tooth preparation on fracture toughness of single zirconia ceramic crowns. Methods. The research was performed as an experimental study. Sixty (60) ceramic crowns were made on non-carious extracted human premolars. Thirty (30) crowns were made on the basis of feather-edge preparation (experimental group I). The group II included 30 crowns made on 1 mm rounded shoulder. Crowns fabrication was executed on a copy mill production system 'Zirkonzahn' (Zirkonzahn GMBH, Gais, Germany). The spherical compression test was used to determine fracture toughness, using 6 mm diameter ceramic ball. Fracture load for damaging ceramic crown was recorded on a universal testing machine - Zwick, type 1464, with the speed of 0.05 mm/min. Results. The results of this research introduced significant differences between fracture toughness of ceramic samples in every examined group. However, fracture toughness of crowns from both group was above 2 000 N, what was double beyond a recommended value. The mean value of fracture toughness in the feather-edge group was 2 090 N, and in shoulder group it was 2 214 N. Conclusion. This research showed a high fracture toughness of zirconia crowns made on feather-edge preparation. The examined crowns showed a fracture resistance at a sufficient distance in relation to the minimum values of functional loads. Further research of functional loads of these crown is necessary, as well as research of marginal adaptation of cemented crowns and gingival inflammatory response.
AB  - Uvod/Cilj. Otpornost na lom uslovljava čvrstoću krune u toku funkcionalnih opterećenja i sprečava oštećenje keramike u toku mastikacije. U literaturi nema podataka o otpornosti na lom kruna izrađenih na bazi linijske preparacije. Mehaničkim testiranjem keramičkih uzoraka treba pokazati da li se linijska preparacija zuba može primeniti bez rizika od degradacije mehaničkih osobina keramičkih kruna. Ovo istraživanje sprovedeno je sa ciljem da se utvrdi uticaj linijske preparacije zuba na otpornost na lom pojedinačnih cirkonijumskih keramičkih kruna. Metode. Istraživanje je obavljeno kao eksperimentalna studija. Izrađeno je ukupno 60 keramičkih kruna na nekarioznim ekstrahovanim humanim premolarima. Ukupno 30 kruna izrađeno je na bazi linijske preparacije (prva eksperimentalna grupa), dok je u drugoj grupi izrađeno 30 kruna na osnovu preparacije oblika pravouglog stepenika sa unutrašnjim zaobljenjem. Za izradu kruna korišćen je kopir-frez sistem 'Zirkonzahn' (Zirkonzahn GMBH, Gais, Germany). Za određivanje otpornosti na lom primenjen je test pritiska sa sferičnim opterećenjem - keramičkom kuglom prečnika 6 mm. Sila potrebna da dovede do loma keramičke krune zabeležena je na univerzalnoj mašini za testiranje materijala Zwick, tipa 1464, koja se kretala brzinom od 0,05 mm/min. Rezultati. Rezultati ovog ispitivanja ukazali su na značajne razlike između otpornosti na lom dve ispitivane grupe kruna. Prosečna otpornost na lom obe grupe kruna bila je iznad 2 000 N, što je dvostruko više od preporučene vrednosti. Krune na bazi linijske preparacije imale su prosečnu vrednost otpornosti na lom od 2 090 N, dok je u drugoj grupi otpornost iznosila 2 214 N. Zaključak Eksperimentalnim ispitivanjem utvrđena je visoka otpornost na lom cirkonijumskih keramičkih kruna izrađenih na osnovu linijske preparacije zuba. Ispitivane krune imale su otpornost na lom na dovoljnoj distanci u odnosu na minimalne vrednosti funkcionalnog opterećenja. Neophodna su dalja istraživanja funkcionalnog opterećenja ovakvih kruna u uslovima in vivo kao i ispitivanje rubnog zaptivanja cementiranih kruna i inflamatornog odgovora gingive.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Fracture toughness of zirconia ceramic crowns made by feather-edge tooth preparation design
T1  - Otpornost na lom cirkonijumskih keramičkih kruna izrađenih na bazi linijske preparacije zuba
VL  - 69
IS  - 7
SP  - 562
EP  - 568
DO  - 10.2298/VSP100820004M
ER  - 

@article{
author = "Mirković, Nemanja and Špadijer-Gostović, Aleksandra and Lazić, Zoran and Trifković, Branka",
year = "2012",
abstract = "Background/Aim. Fracture toughness determines functional crown strenght and prevents damages on ceramics during mastication. There is a lack of relevant literature data about fracture toughness of crowns made by feather-edge preparation. Mechanical testing of ceramic samples is supposed to show if feather-edge tooth preparation is a successful method for making ceramic crowns without any risk of reduction of their mechanical properties. This research was done to establish effects of feather-edge tooth preparation on fracture toughness of single zirconia ceramic crowns. Methods. The research was performed as an experimental study. Sixty (60) ceramic crowns were made on non-carious extracted human premolars. Thirty (30) crowns were made on the basis of feather-edge preparation (experimental group I). The group II included 30 crowns made on 1 mm rounded shoulder. Crowns fabrication was executed on a copy mill production system 'Zirkonzahn' (Zirkonzahn GMBH, Gais, Germany). The spherical compression test was used to determine fracture toughness, using 6 mm diameter ceramic ball. Fracture load for damaging ceramic crown was recorded on a universal testing machine - Zwick, type 1464, with the speed of 0.05 mm/min. Results. The results of this research introduced significant differences between fracture toughness of ceramic samples in every examined group. However, fracture toughness of crowns from both group was above 2 000 N, what was double beyond a recommended value. The mean value of fracture toughness in the feather-edge group was 2 090 N, and in shoulder group it was 2 214 N. Conclusion. This research showed a high fracture toughness of zirconia crowns made on feather-edge preparation. The examined crowns showed a fracture resistance at a sufficient distance in relation to the minimum values of functional loads. Further research of functional loads of these crown is necessary, as well as research of marginal adaptation of cemented crowns and gingival inflammatory response., Uvod/Cilj. Otpornost na lom uslovljava čvrstoću krune u toku funkcionalnih opterećenja i sprečava oštećenje keramike u toku mastikacije. U literaturi nema podataka o otpornosti na lom kruna izrađenih na bazi linijske preparacije. Mehaničkim testiranjem keramičkih uzoraka treba pokazati da li se linijska preparacija zuba može primeniti bez rizika od degradacije mehaničkih osobina keramičkih kruna. Ovo istraživanje sprovedeno je sa ciljem da se utvrdi uticaj linijske preparacije zuba na otpornost na lom pojedinačnih cirkonijumskih keramičkih kruna. Metode. Istraživanje je obavljeno kao eksperimentalna studija. Izrađeno je ukupno 60 keramičkih kruna na nekarioznim ekstrahovanim humanim premolarima. Ukupno 30 kruna izrađeno je na bazi linijske preparacije (prva eksperimentalna grupa), dok je u drugoj grupi izrađeno 30 kruna na osnovu preparacije oblika pravouglog stepenika sa unutrašnjim zaobljenjem. Za izradu kruna korišćen je kopir-frez sistem 'Zirkonzahn' (Zirkonzahn GMBH, Gais, Germany). Za određivanje otpornosti na lom primenjen je test pritiska sa sferičnim opterećenjem - keramičkom kuglom prečnika 6 mm. Sila potrebna da dovede do loma keramičke krune zabeležena je na univerzalnoj mašini za testiranje materijala Zwick, tipa 1464, koja se kretala brzinom od 0,05 mm/min. Rezultati. Rezultati ovog ispitivanja ukazali su na značajne razlike između otpornosti na lom dve ispitivane grupe kruna. Prosečna otpornost na lom obe grupe kruna bila je iznad 2 000 N, što je dvostruko više od preporučene vrednosti. Krune na bazi linijske preparacije imale su prosečnu vrednost otpornosti na lom od 2 090 N, dok je u drugoj grupi otpornost iznosila 2 214 N. Zaključak Eksperimentalnim ispitivanjem utvrđena je visoka otpornost na lom cirkonijumskih keramičkih kruna izrađenih na osnovu linijske preparacije zuba. Ispitivane krune imale su otpornost na lom na dovoljnoj distanci u odnosu na minimalne vrednosti funkcionalnog opterećenja. Neophodna su dalja istraživanja funkcionalnog opterećenja ovakvih kruna u uslovima in vivo kao i ispitivanje rubnog zaptivanja cementiranih kruna i inflamatornog odgovora gingive.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Fracture toughness of zirconia ceramic crowns made by feather-edge tooth preparation design, Otpornost na lom cirkonijumskih keramičkih kruna izrađenih na bazi linijske preparacije zuba",
volume = "69",
number = "7",
pages = "562-568",
doi = "10.2298/VSP100820004M"
}

Mirković, N., Špadijer-Gostović, A., Lazić, Z.,& Trifković, B.. (2012). Fracture toughness of zirconia ceramic crowns made by feather-edge tooth preparation design. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 69(7), 562-568.
https://doi.org/10.2298/VSP100820004M

Mirković N, Špadijer-Gostović A, Lazić Z, Trifković B. Fracture toughness of zirconia ceramic crowns made by feather-edge tooth preparation design. in Vojnosanitetski pregled. 2012;69(7):562-568.
doi:10.2298/VSP100820004M .

Mirković, Nemanja, Špadijer-Gostović, Aleksandra, Lazić, Zoran, Trifković, Branka, "Fracture toughness of zirconia ceramic crowns made by feather-edge tooth preparation design" in Vojnosanitetski pregled, 69, no. 7 (2012):562-568,
https://doi.org/10.2298/VSP100820004M . .