TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Andrić, Miroslav
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Jovanović, Tanja
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2493
AB  - Objectives: This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator of nuclear factor kappa-? ligand (RANKL) and osteoprotegerin (OPG)), and proinflammatory cytokines (tumour necrosis factor-alpha (TNF-?), interleukin-1 beta (IL-1?) and IL-6) compared to EBV negative lesions. Additionally, the potential correlation between investigated molecules in periapical lesions was analyzed. Materials and methods: Sixty-four apical periodontitis lesions were obtained subsequent to standard apicoectomy procedure. The presence of EBV was determined using nested PCR. Based on the presence of EBV all periapical lesions were divided into two groups, 29 EBV positive and 35 EBV negative lesions. A reverse transcriptase real-time PCR was used to determine mRNA levels of Notch2, Jagged1, RANKL, OPG, TNF-?, IL-1? and IL-6. Results: Significantly higher mRNA levels of Notch2, Jagged1, RANKL and IL-1? were observed in EBV positive compared to EBV negative lesions. Significant positive correlation was present between Notch2 and Jagged1, Jagged1 and RANKL, and IL-? and TNF-? in EBV positive periapical lesions. Conclusions: Notch signalling pathway may be involved in alveolar bone resorption in apical periodontitis lesions infected by EBV.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Acta Odontologica Scandinavica
T1  - Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis
VL  - 78
IS  - 2
SP  - 126
EP  - 131
DO  - 10.1080/00016357.2019.1658896
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Čarkić, Jelena and Andrić, Miroslav and Miletić, Maja and Beljić-Ivanović, Katarina and Jovanović, Tanja and Milašin, Jelena",
year = "2020",
abstract = "Objectives: This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator of nuclear factor kappa-? ligand (RANKL) and osteoprotegerin (OPG)), and proinflammatory cytokines (tumour necrosis factor-alpha (TNF-?), interleukin-1 beta (IL-1?) and IL-6) compared to EBV negative lesions. Additionally, the potential correlation between investigated molecules in periapical lesions was analyzed. Materials and methods: Sixty-four apical periodontitis lesions were obtained subsequent to standard apicoectomy procedure. The presence of EBV was determined using nested PCR. Based on the presence of EBV all periapical lesions were divided into two groups, 29 EBV positive and 35 EBV negative lesions. A reverse transcriptase real-time PCR was used to determine mRNA levels of Notch2, Jagged1, RANKL, OPG, TNF-?, IL-1? and IL-6. Results: Significantly higher mRNA levels of Notch2, Jagged1, RANKL and IL-1? were observed in EBV positive compared to EBV negative lesions. Significant positive correlation was present between Notch2 and Jagged1, Jagged1 and RANKL, and IL-? and TNF-? in EBV positive periapical lesions. Conclusions: Notch signalling pathway may be involved in alveolar bone resorption in apical periodontitis lesions infected by EBV.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Acta Odontologica Scandinavica",
title = "Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis",
volume = "78",
number = "2",
pages = "126-131",
doi = "10.1080/00016357.2019.1658896"
}

Jakovljević, A., Nikolić, N., Čarkić, J., Andrić, M., Miletić, M., Beljić-Ivanović, K., Jovanović, T.,& Milašin, J.. (2020). Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis. in Acta Odontologica Scandinavica
Taylor & Francis Ltd, Abingdon., 78(2), 126-131.
https://doi.org/10.1080/00016357.2019.1658896

Jakovljević A, Nikolić N, Čarkić J, Andrić M, Miletić M, Beljić-Ivanović K, Jovanović T, Milašin J. Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis. in Acta Odontologica Scandinavica. 2020;78(2):126-131.
doi:10.1080/00016357.2019.1658896 .

Jakovljević, Aleksandar, Nikolić, Nadja, Čarkić, Jelena, Andrić, Miroslav, Miletić, Maja, Beljić-Ivanović, Katarina, Jovanović, Tanja, Milašin, Jelena, "Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis" in Acta Odontologica Scandinavica, 78, no. 2 (2020):126-131,
https://doi.org/10.1080/00016357.2019.1658896 . .

TY  - JOUR
AU  - Canullo, Luigi
AU  - Pesce, Paolo
AU  - Botticelli, Daniele
AU  - Covani, Ugo
AU  - Janković, Saša
AU  - Jovanović, Tanja
AU  - Rakić, Mia
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2309
AB  - Purpose: To compare the qualitative and quantitative profile of Epstein-Barr virus (EBV) at external and internal implant surfaces between participants with peri-implantitis and healthy peri-implant tissues and to quantitatively assess the relation between EBV and periopathogens inside the microbiologic profile associated with peri-implantitis. Materials and Methods: Microbiologic specimens were retrieved from 84 patients wearing 190 implants to estimate the levels of EBV and 10 periopathogens in the peri-implant pocket and internal-implant connection using quantitative polymerase chain reaction. Results: The study sample consisted of 113 healthy and 77 peri-implantitis-affected implants. Statistical significance was not reached in EBV prevalence between peri-implantitis and healthy controls. EBV-positive participants demonstrated higher levels of Prevotella intermedia (Pi) and Campylobacter rectus (Cr) compared with EBV-negative participants. A positive correlation was demonstrated among EBV and Tannerella forsythia (Tf), Parvimonas micra (Pm), Fusobacterium nucleatum (Fn), and Cr levels in peri-implantitis-affected implants, while healthy controls demonstrated a positive correlation between EBV and Aggregatibacter actinomycetemcomitans (Aa), Pi, and Pm. Conclusion: EBV cannot be considered as a microbiologic marker of peri-implantitis. However, EBV could be considered as a risk factor and a peri-implantitis enhancer based on its positive correlations with pathogens associated with peri-implantitis.
PB  - Quintessence Publishing Co Inc, Hanover Park
T2  - International Journal of Oral & Maxillofacial Implants
T1  - What is the Impact of Epstein-Barr Virus in Peri-implant Infection?
VL  - 33
IS  - 1
SP  - 58
EP  - 63
DO  - 10.11607/jomi.5972
ER  - 

@article{
author = "Canullo, Luigi and Pesce, Paolo and Botticelli, Daniele and Covani, Ugo and Janković, Saša and Jovanović, Tanja and Rakić, Mia",
year = "2018",
abstract = "Purpose: To compare the qualitative and quantitative profile of Epstein-Barr virus (EBV) at external and internal implant surfaces between participants with peri-implantitis and healthy peri-implant tissues and to quantitatively assess the relation between EBV and periopathogens inside the microbiologic profile associated with peri-implantitis. Materials and Methods: Microbiologic specimens were retrieved from 84 patients wearing 190 implants to estimate the levels of EBV and 10 periopathogens in the peri-implant pocket and internal-implant connection using quantitative polymerase chain reaction. Results: The study sample consisted of 113 healthy and 77 peri-implantitis-affected implants. Statistical significance was not reached in EBV prevalence between peri-implantitis and healthy controls. EBV-positive participants demonstrated higher levels of Prevotella intermedia (Pi) and Campylobacter rectus (Cr) compared with EBV-negative participants. A positive correlation was demonstrated among EBV and Tannerella forsythia (Tf), Parvimonas micra (Pm), Fusobacterium nucleatum (Fn), and Cr levels in peri-implantitis-affected implants, while healthy controls demonstrated a positive correlation between EBV and Aggregatibacter actinomycetemcomitans (Aa), Pi, and Pm. Conclusion: EBV cannot be considered as a microbiologic marker of peri-implantitis. However, EBV could be considered as a risk factor and a peri-implantitis enhancer based on its positive correlations with pathogens associated with peri-implantitis.",
publisher = "Quintessence Publishing Co Inc, Hanover Park",
journal = "International Journal of Oral & Maxillofacial Implants",
title = "What is the Impact of Epstein-Barr Virus in Peri-implant Infection?",
volume = "33",
number = "1",
pages = "58-63",
doi = "10.11607/jomi.5972"
}

Canullo, L., Pesce, P., Botticelli, D., Covani, U., Janković, S., Jovanović, T.,& Rakić, M.. (2018). What is the Impact of Epstein-Barr Virus in Peri-implant Infection?. in International Journal of Oral & Maxillofacial Implants
Quintessence Publishing Co Inc, Hanover Park., 33(1), 58-63.
https://doi.org/10.11607/jomi.5972

Canullo L, Pesce P, Botticelli D, Covani U, Janković S, Jovanović T, Rakić M. What is the Impact of Epstein-Barr Virus in Peri-implant Infection?. in International Journal of Oral & Maxillofacial Implants. 2018;33(1):58-63.
doi:10.11607/jomi.5972 .

Canullo, Luigi, Pesce, Paolo, Botticelli, Daniele, Covani, Ugo, Janković, Saša, Jovanović, Tanja, Rakić, Mia, "What is the Impact of Epstein-Barr Virus in Peri-implant Infection?" in International Journal of Oral & Maxillofacial Implants, 33, no. 1 (2018):58-63,
https://doi.org/10.11607/jomi.5972 . .

TY  - CHAP
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Jovanović, Tanja
AU  - Kesić, Ljiljana
AU  - Milasin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2597
AB  - Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.
PB  - Rijeka : InTech
T2  - Herpesviridae
T1  - Herpesviruses in Periapical Pathoses: An Updated Systematic Review
SP  - 31
EP  - 74
DO  - 10.5772/64004
ER  - 

@inbook{
editor = "Ongrádi, Joseph",
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Miletić, Maja and Jovanović, Tanja and Kesić, Ljiljana and Milasin, Jelena",
year = "2016",
abstract = "Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.",
publisher = "Rijeka : InTech",
journal = "Herpesviridae",
booktitle = "Herpesviruses in Periapical Pathoses: An Updated Systematic Review",
pages = "31-74",
doi = "10.5772/64004"
}

Ongrádi, J., Jakovljević, A., Andrić, M., Knežević, A., Beljić-Ivanović, K., Miletić, M., Jovanović, T., Kesić, L.,& Milasin, J.. (2016). Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae
Rijeka : InTech., 31-74.
https://doi.org/10.5772/64004

Ongrádi J, Jakovljević A, Andrić M, Knežević A, Beljić-Ivanović K, Miletić M, Jovanović T, Kesić L, Milasin J. Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae. 2016;:31-74.
doi:10.5772/64004 .

Ongrádi, Joseph, Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Miletić, Maja, Jovanović, Tanja, Kesić, Ljiljana, Milasin, Jelena, "Herpesviruses in Periapical Pathoses: An Updated Systematic Review" in Herpesviridae (2016):31-74,
https://doi.org/10.5772/64004 . .

TY  - JOUR
AU  - Đurić, Milanko
AU  - Janković, Ljiljana
AU  - Jovanović, Tanja
AU  - Pavlica, Dušan
AU  - Brkić, Snežana
AU  - Knežević, Aleksandra
AU  - Marković, Dubravka
AU  - Milašin, Jelena
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1504
AB  - Oral reactivation of latent Herpes simplex virus (HSV) infection may easily occur in cancer patients. Virus reactivation can cause oral mucosa damage, worsen already existing lesions caused by stomatotoxic effect of cancer therapy and, whether symptomatic or asymptomatic, ample spreading and promote viral transmission. Polymerase chain reaction (PCR), cell-culture and direct immunofluorescence have been used to determine the frequency of oral HSV reactivation in 60 patients undergoing chemotherapy for different malignancies. By means of PCR, the presence of viral DNA was detected in 71.7% of patients prior to chemotherapy and in 85.0% after chemotherapy. 33.3% of patients before and 40.0% after chemotherapy were viral-culture positive, while 3.3% of patients before and 11.7% after chemotherapy were positive as shown by direct immunofluorescence. No significant difference in HSV-1 reactivation was found before and after chemotherapy. In addition, no significant difference was found when comparing HSV-1 reactivation in patients with and without mucositis. HSV-2 was not detected in any of the patients. Reactivation of latent HSV is exceptionally frequent in cancer patients. The results of this study suggest that virus reactivation occurs independently of cancer chemotherapy. The potential role of HSV reactivation in oral mucosa damage remains unclear.
PB  - Wiley, Hoboken
T2  - Journal of Oral Pathology & Medicine
T1  - Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection
VL  - 38
IS  - 2
SP  - 167
EP  - 173
DO  - 10.1111/j.1600-0714.2008.00684.x
ER  - 

@article{
author = "Đurić, Milanko and Janković, Ljiljana and Jovanović, Tanja and Pavlica, Dušan and Brkić, Snežana and Knežević, Aleksandra and Marković, Dubravka and Milašin, Jelena",
year = "2009",
abstract = "Oral reactivation of latent Herpes simplex virus (HSV) infection may easily occur in cancer patients. Virus reactivation can cause oral mucosa damage, worsen already existing lesions caused by stomatotoxic effect of cancer therapy and, whether symptomatic or asymptomatic, ample spreading and promote viral transmission. Polymerase chain reaction (PCR), cell-culture and direct immunofluorescence have been used to determine the frequency of oral HSV reactivation in 60 patients undergoing chemotherapy for different malignancies. By means of PCR, the presence of viral DNA was detected in 71.7% of patients prior to chemotherapy and in 85.0% after chemotherapy. 33.3% of patients before and 40.0% after chemotherapy were viral-culture positive, while 3.3% of patients before and 11.7% after chemotherapy were positive as shown by direct immunofluorescence. No significant difference in HSV-1 reactivation was found before and after chemotherapy. In addition, no significant difference was found when comparing HSV-1 reactivation in patients with and without mucositis. HSV-2 was not detected in any of the patients. Reactivation of latent HSV is exceptionally frequent in cancer patients. The results of this study suggest that virus reactivation occurs independently of cancer chemotherapy. The potential role of HSV reactivation in oral mucosa damage remains unclear.",
publisher = "Wiley, Hoboken",
journal = "Journal of Oral Pathology & Medicine",
title = "Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection",
volume = "38",
number = "2",
pages = "167-173",
doi = "10.1111/j.1600-0714.2008.00684.x"
}

Đurić, M., Janković, L., Jovanović, T., Pavlica, D., Brkić, S., Knežević, A., Marković, D.,& Milašin, J.. (2009). Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection. in Journal of Oral Pathology & Medicine
Wiley, Hoboken., 38(2), 167-173.
https://doi.org/10.1111/j.1600-0714.2008.00684.x

Đurić M, Janković L, Jovanović T, Pavlica D, Brkić S, Knežević A, Marković D, Milašin J. Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection. in Journal of Oral Pathology & Medicine. 2009;38(2):167-173.
doi:10.1111/j.1600-0714.2008.00684.x .

Đurić, Milanko, Janković, Ljiljana, Jovanović, Tanja, Pavlica, Dušan, Brkić, Snežana, Knežević, Aleksandra, Marković, Dubravka, Milašin, Jelena, "Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection" in Journal of Oral Pathology & Medicine, 38, no. 2 (2009):167-173,
https://doi.org/10.1111/j.1600-0714.2008.00684.x . .

TY  - JOUR
AU  - Jovanović, Tanja
AU  - Pavlica, Dušan
AU  - Knežević, Aleksandra
AU  - Lazarević, Ivana B.
PY  - 2004
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1211
AB  - It is well known that the most of AIDS patient have evidence of more severe herpetic infection than immunocompetent persons. In this study we examined the characteristics of humoral immune response during active herpes simplex virus infection in immunocompetent and immunocompromised patients, and correlate the value of specific markers (titre of specific anti-HSV-IgM, anti-HSV-IgG antibody, titre of neutralization antibody and avidity of IgG) between these 2 groups. The results have shown that although AIDS patients have severe depression of their cellular immune response, they can mount an intensive humoral antiviral response during the active HSV-1 infection. They have higher titre and avidity of specific anti-HSV antibody than immunocompetent persons. But even with high titre of specific antibody, AIDS patient have no enough neutralizing antibodies. According to the clinical manifestation of herpetic infection in AIDS patient, our result showed significant association between the quantity of in vitro neutralizing activity and in vivo protection from severe herpetic infection.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Stomatology
T1  - Virus specific humoral immune response to Herpes Simplex Virus (HSV) in AIDS patients with oropharyngeal herpes simplex infection
VL  - 8
IS  - 2
SP  - 96
EP  - 98
UR  - https://hdl.handle.net/21.15107/rcub_smile_1211
ER  - 

@article{
author = "Jovanović, Tanja and Pavlica, Dušan and Knežević, Aleksandra and Lazarević, Ivana B.",
year = "2004",
abstract = "It is well known that the most of AIDS patient have evidence of more severe herpetic infection than immunocompetent persons. In this study we examined the characteristics of humoral immune response during active herpes simplex virus infection in immunocompetent and immunocompromised patients, and correlate the value of specific markers (titre of specific anti-HSV-IgM, anti-HSV-IgG antibody, titre of neutralization antibody and avidity of IgG) between these 2 groups. The results have shown that although AIDS patients have severe depression of their cellular immune response, they can mount an intensive humoral antiviral response during the active HSV-1 infection. They have higher titre and avidity of specific anti-HSV antibody than immunocompetent persons. But even with high titre of specific antibody, AIDS patient have no enough neutralizing antibodies. According to the clinical manifestation of herpetic infection in AIDS patient, our result showed significant association between the quantity of in vitro neutralizing activity and in vivo protection from severe herpetic infection.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Stomatology",
title = "Virus specific humoral immune response to Herpes Simplex Virus (HSV) in AIDS patients with oropharyngeal herpes simplex infection",
volume = "8",
number = "2",
pages = "96-98",
url = "https://hdl.handle.net/21.15107/rcub_smile_1211"
}

Jovanović, T., Pavlica, D., Knežević, A.,& Lazarević, I. B.. (2004). Virus specific humoral immune response to Herpes Simplex Virus (HSV) in AIDS patients with oropharyngeal herpes simplex infection. in Balkan Journal of Stomatology
Udruženje stomatologa Balkana., 8(2), 96-98.
https://hdl.handle.net/21.15107/rcub_smile_1211

Jovanović T, Pavlica D, Knežević A, Lazarević IB. Virus specific humoral immune response to Herpes Simplex Virus (HSV) in AIDS patients with oropharyngeal herpes simplex infection. in Balkan Journal of Stomatology. 2004;8(2):96-98.
https://hdl.handle.net/21.15107/rcub_smile_1211 .

Jovanović, Tanja, Pavlica, Dušan, Knežević, Aleksandra, Lazarević, Ivana B., "Virus specific humoral immune response to Herpes Simplex Virus (HSV) in AIDS patients with oropharyngeal herpes simplex infection" in Balkan Journal of Stomatology, 8, no. 2 (2004):96-98,
https://hdl.handle.net/21.15107/rcub_smile_1211 .