TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Jaćimović, Jelena
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
AU  - Aminoshariae, Anita
AU  - Azarpazhooh, Amir
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2577
AB  - Introduction
This study aimed to perform a more precise estimation of the association between tumor necrosis factor-alpha (TNF-α) – 308 G/A single nucleotide polymorphism (SNP) and the risk of development of AP and its phenotypes based on all available published studies.
Methods
The study was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and is registered in PROSPERO (CRD42020176190). The literature search was conducted via: Clarivate Analytics’ Scopus, PubMed, Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure databases, from inception to December 2020 with no language restrictions. Two reviewers were involved independently in study selection, data extraction and appraising the studies that were included. The quality of included studies was evaluated using the Strengthening the Reporting of Genetic Association (STREGA) and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Frequencies of genotypes and alleles of TNF-alpha (G>A 308, rs1800629) gene, with 95% Odds ratio was used.
Results
Four studies met the inclusion criteria with moderate risk of bias. This study revealed no significant association between TNF-α – 308 G/A SNP and AP, and the risk of AP development. Moreover, there was no significant association between genotype or allele frequency distribution and clinical manifestations (acute versus chronic) of AP. The certainty of evidence per GRADE was very low.
Conclusions
Due to very low certainty of evidence, whether there is an association between TNF-α – 308 G/A SNP and AP, warrants further well-designed multi-centric studies to adjudicate a better understanding of the role of genetic factors in the etiopathogenesis of AP.
PB  - Elsevier
T2  - Journal of Endodontics
T1  - TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis
DO  - 10.1016/j.joen.2021.03.007
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Jaćimović, Jelena and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena and Aminoshariae, Anita and Azarpazhooh, Amir",
year = "2021",
abstract = "Introduction
This study aimed to perform a more precise estimation of the association between tumor necrosis factor-alpha (TNF-α) – 308 G/A single nucleotide polymorphism (SNP) and the risk of development of AP and its phenotypes based on all available published studies.
Methods
The study was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and is registered in PROSPERO (CRD42020176190). The literature search was conducted via: Clarivate Analytics’ Scopus, PubMed, Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure databases, from inception to December 2020 with no language restrictions. Two reviewers were involved independently in study selection, data extraction and appraising the studies that were included. The quality of included studies was evaluated using the Strengthening the Reporting of Genetic Association (STREGA) and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Frequencies of genotypes and alleles of TNF-alpha (G>A 308, rs1800629) gene, with 95% Odds ratio was used.
Results
Four studies met the inclusion criteria with moderate risk of bias. This study revealed no significant association between TNF-α – 308 G/A SNP and AP, and the risk of AP development. Moreover, there was no significant association between genotype or allele frequency distribution and clinical manifestations (acute versus chronic) of AP. The certainty of evidence per GRADE was very low.
Conclusions
Due to very low certainty of evidence, whether there is an association between TNF-α – 308 G/A SNP and AP, warrants further well-designed multi-centric studies to adjudicate a better understanding of the role of genetic factors in the etiopathogenesis of AP.",
publisher = "Elsevier",
journal = "Journal of Endodontics",
title = "TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis",
doi = "10.1016/j.joen.2021.03.007"
}

Jakovljević, A., Nikolić, N., Jaćimović, J., Miletić, M., Andrić, M., Milašin, J., Aminoshariae, A.,& Azarpazhooh, A.. (2021). TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis. in Journal of Endodontics
Elsevier..
https://doi.org/10.1016/j.joen.2021.03.007

Jakovljević A, Nikolić N, Jaćimović J, Miletić M, Andrić M, Milašin J, Aminoshariae A, Azarpazhooh A. TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis. in Journal of Endodontics. 2021;.
doi:10.1016/j.joen.2021.03.007 .

Jakovljević, Aleksandar, Nikolić, Nadja, Jaćimović, Jelena, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, Aminoshariae, Anita, Azarpazhooh, Amir, "TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis" in Journal of Endodontics (2021),
https://doi.org/10.1016/j.joen.2021.03.007 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Jaćimović, Jelena
AU  - Pavlović, Ognjan
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2570
AB  - Introduction
 This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.
 
 Methods
 An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.
 
 Results
 Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.
 
 Conclusions
 There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.
PB  - Elsevier Inc.
T2  - Journal of Endodontics
T1  - Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020
VL  - 46
IS  - 10
SP  - 1371
EP  - 1386.e8
DO  - 10.1016/j.joen.2020.07.007
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Jaćimović, Jelena and Pavlović, Ognjan and Miličić, Biljana and Beljić-Ivanović, Katarina and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Introduction
 This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.
 
 Methods
 An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.
 
 Results
 Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.
 
 Conclusions
 There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.",
publisher = "Elsevier Inc.",
journal = "Journal of Endodontics",
title = "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020",
volume = "46",
number = "10",
pages = "1371-1386.e8",
doi = "10.1016/j.joen.2020.07.007"
}

Jakovljević, A., Nikolić, N., Jaćimović, J., Pavlović, O., Miličić, B., Beljić-Ivanović, K., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics
Elsevier Inc.., 46(10), 1371-1386.e8.
https://doi.org/10.1016/j.joen.2020.07.007

Jakovljević A, Nikolić N, Jaćimović J, Pavlović O, Miličić B, Beljić-Ivanović K, Miletić M, Andrić M, Milašin J. Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics. 2020;46(10):1371-1386.e8.
doi:10.1016/j.joen.2020.07.007 .

Jakovljević, Aleksandar, Nikolić, Nadja, Jaćimović, Jelena, Pavlović, Ognjan, Miličić, Biljana, Beljić-Ivanović, Katarina, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020" in Journal of Endodontics, 46, no. 10 (2020):1371-1386.e8,
https://doi.org/10.1016/j.joen.2020.07.007 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Jaćimović, Jelena
AU  - Pavlović, Ognjan
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2531
AB  - Introduction
This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.

Methods
An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.

Results
Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.

Conclusions
There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.
PB  - Elsevier Inc.
T2  - Journal of Endodontics
T1  - Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020
VL  - 46
IS  - 10
SP  - 1371
EP  - 1386
DO  - 10.1016/j.joen.2020.07.007
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Jaćimović, Jelena and Pavlović, Ognjan and Miličić, Biljana and Beljić-Ivanović, Katarina and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Introduction
This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.

Methods
An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.

Results
Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.

Conclusions
There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.",
publisher = "Elsevier Inc.",
journal = "Journal of Endodontics",
title = "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020",
volume = "46",
number = "10",
pages = "1371-1386",
doi = "10.1016/j.joen.2020.07.007"
}

Jakovljević, A., Nikolić, N., Jaćimović, J., Pavlović, O., Miličić, B., Beljić-Ivanović, K., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics
Elsevier Inc.., 46(10), 1371-1386.
https://doi.org/10.1016/j.joen.2020.07.007

Jakovljević A, Nikolić N, Jaćimović J, Pavlović O, Miličić B, Beljić-Ivanović K, Miletić M, Andrić M, Milašin J. Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics. 2020;46(10):1371-1386.
doi:10.1016/j.joen.2020.07.007 .

Jakovljević, Aleksandar, Nikolić, Nadja, Jaćimović, Jelena, Pavlović, Ognjan, Miličić, Biljana, Beljić-Ivanović, Katarina, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020" in Journal of Endodontics, 46, no. 10 (2020):1371-1386,
https://doi.org/10.1016/j.joen.2020.07.007 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Andrić, Miroslav
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Jovanović, Tanja
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2493
AB  - Objectives: This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator of nuclear factor kappa-? ligand (RANKL) and osteoprotegerin (OPG)), and proinflammatory cytokines (tumour necrosis factor-alpha (TNF-?), interleukin-1 beta (IL-1?) and IL-6) compared to EBV negative lesions. Additionally, the potential correlation between investigated molecules in periapical lesions was analyzed. Materials and methods: Sixty-four apical periodontitis lesions were obtained subsequent to standard apicoectomy procedure. The presence of EBV was determined using nested PCR. Based on the presence of EBV all periapical lesions were divided into two groups, 29 EBV positive and 35 EBV negative lesions. A reverse transcriptase real-time PCR was used to determine mRNA levels of Notch2, Jagged1, RANKL, OPG, TNF-?, IL-1? and IL-6. Results: Significantly higher mRNA levels of Notch2, Jagged1, RANKL and IL-1? were observed in EBV positive compared to EBV negative lesions. Significant positive correlation was present between Notch2 and Jagged1, Jagged1 and RANKL, and IL-? and TNF-? in EBV positive periapical lesions. Conclusions: Notch signalling pathway may be involved in alveolar bone resorption in apical periodontitis lesions infected by EBV.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Acta Odontologica Scandinavica
T1  - Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis
VL  - 78
IS  - 2
SP  - 126
EP  - 131
DO  - 10.1080/00016357.2019.1658896
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Čarkić, Jelena and Andrić, Miroslav and Miletić, Maja and Beljić-Ivanović, Katarina and Jovanović, Tanja and Milašin, Jelena",
year = "2020",
abstract = "Objectives: This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator of nuclear factor kappa-? ligand (RANKL) and osteoprotegerin (OPG)), and proinflammatory cytokines (tumour necrosis factor-alpha (TNF-?), interleukin-1 beta (IL-1?) and IL-6) compared to EBV negative lesions. Additionally, the potential correlation between investigated molecules in periapical lesions was analyzed. Materials and methods: Sixty-four apical periodontitis lesions were obtained subsequent to standard apicoectomy procedure. The presence of EBV was determined using nested PCR. Based on the presence of EBV all periapical lesions were divided into two groups, 29 EBV positive and 35 EBV negative lesions. A reverse transcriptase real-time PCR was used to determine mRNA levels of Notch2, Jagged1, RANKL, OPG, TNF-?, IL-1? and IL-6. Results: Significantly higher mRNA levels of Notch2, Jagged1, RANKL and IL-1? were observed in EBV positive compared to EBV negative lesions. Significant positive correlation was present between Notch2 and Jagged1, Jagged1 and RANKL, and IL-? and TNF-? in EBV positive periapical lesions. Conclusions: Notch signalling pathway may be involved in alveolar bone resorption in apical periodontitis lesions infected by EBV.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Acta Odontologica Scandinavica",
title = "Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis",
volume = "78",
number = "2",
pages = "126-131",
doi = "10.1080/00016357.2019.1658896"
}

Jakovljević, A., Nikolić, N., Čarkić, J., Andrić, M., Miletić, M., Beljić-Ivanović, K., Jovanović, T.,& Milašin, J.. (2020). Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis. in Acta Odontologica Scandinavica
Taylor & Francis Ltd, Abingdon., 78(2), 126-131.
https://doi.org/10.1080/00016357.2019.1658896

Jakovljević A, Nikolić N, Čarkić J, Andrić M, Miletić M, Beljić-Ivanović K, Jovanović T, Milašin J. Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis. in Acta Odontologica Scandinavica. 2020;78(2):126-131.
doi:10.1080/00016357.2019.1658896 .

Jakovljević, Aleksandar, Nikolić, Nadja, Čarkić, Jelena, Andrić, Miroslav, Miletić, Maja, Beljić-Ivanović, Katarina, Jovanović, Tanja, Milašin, Jelena, "Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis" in Acta Odontologica Scandinavica, 78, no. 2 (2020):126-131,
https://doi.org/10.1080/00016357.2019.1658896 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Beljić-Ivanović, Katarina
AU  - Soldatović, Ivan
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1047
AB  - Aim To investigate the possible association between TNF alpha (-308 G/A) and IL-1 beta (-511 C/T) single nucleotide polymorphisms (SNPs) and GSTT and GSTM deletion polymorphisms and risk of apical periodontitis (AP) development, and determine the association of different genotypes with the presence of herpesviral infection in AP. Methodology The study included 120 periapical lesions and 200 control samples. Gene polymorphism analysis was performed using either polymerase chain reaction (PCR) or PCR/ restriction fragment length polymorphism (RFLP). Relative gene expression of TNF-alpha and IL-1 beta was analysed using reverse transcriptase - real-time PCR. The presence of Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by nested PCR. Chi-square and Fisher's exact tests and logistic regression analyses were done for polymorphisms, whilst Mann-Whitney U-test was performed for the expression analysis. The expected frequency of variants was analysed by the Hardy-Weinberg equilibrium test. Results TNF-alpha (-308 G/A) SNP increased AP susceptibility for heterozygous (odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.06-2.80, P = 0.027) and homozygous (OR = 8.55, 95% CI = 1.77-41.36, P  lt  0.001) carriers of the variant A allele. On the other hand, IL-1 beta (-511 C/T) polymorphism exerted a protective effect both in heterozygotes (OR = 0.540, 95% CI = 0.332-0.880, P = 0.013) and homozygotes (OR = 0.114, 95% CI = 0.026-0.501, P  lt  0.001). In addition, GSTM1 and GSTT1 null genotypes separately, as well as concomitantly, were associated with an increased risk for AP development (P  lt  0.001). The null GSTT1 genotype increased approximately twice the risk of Epstein-Barr infection (EBV) in AP (OR = 2.17, 95% CI = 1-4.71, P = 0.048), whilst TNF-alpha SNP decreased it, both in heterozygotes (OR = 0.20, 95% CI = 0.08-0.48, P  lt  0.001) and AA homozygotes (OR = 0.07, 95% CI = 0.01-0.37, P = 0.001). Conclusions GSTM and GSTT deletion polymorphisms, as well as TNF alpha (-308 G/A) SNP, are associated with increased risk, whereas IL-1 beta (-511 C/T) polymorphism decreases the risk of AP development. GSTT and TNF alpha polymorphisms also appear to modulate the risk of EBV infection in Serbian patients with AP.
PB  - Wiley, Hoboken
T2  - International Endodontic Journal
T1  - Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?
VL  - 53
IS  - 7
SP  - 895
EP  - 904
DO  - 10.1111/iej.13298
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Čarkić, Jelena and Beljić-Ivanović, Katarina and Soldatović, Ivan and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Aim To investigate the possible association between TNF alpha (-308 G/A) and IL-1 beta (-511 C/T) single nucleotide polymorphisms (SNPs) and GSTT and GSTM deletion polymorphisms and risk of apical periodontitis (AP) development, and determine the association of different genotypes with the presence of herpesviral infection in AP. Methodology The study included 120 periapical lesions and 200 control samples. Gene polymorphism analysis was performed using either polymerase chain reaction (PCR) or PCR/ restriction fragment length polymorphism (RFLP). Relative gene expression of TNF-alpha and IL-1 beta was analysed using reverse transcriptase - real-time PCR. The presence of Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by nested PCR. Chi-square and Fisher's exact tests and logistic regression analyses were done for polymorphisms, whilst Mann-Whitney U-test was performed for the expression analysis. The expected frequency of variants was analysed by the Hardy-Weinberg equilibrium test. Results TNF-alpha (-308 G/A) SNP increased AP susceptibility for heterozygous (odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.06-2.80, P = 0.027) and homozygous (OR = 8.55, 95% CI = 1.77-41.36, P  lt  0.001) carriers of the variant A allele. On the other hand, IL-1 beta (-511 C/T) polymorphism exerted a protective effect both in heterozygotes (OR = 0.540, 95% CI = 0.332-0.880, P = 0.013) and homozygotes (OR = 0.114, 95% CI = 0.026-0.501, P  lt  0.001). In addition, GSTM1 and GSTT1 null genotypes separately, as well as concomitantly, were associated with an increased risk for AP development (P  lt  0.001). The null GSTT1 genotype increased approximately twice the risk of Epstein-Barr infection (EBV) in AP (OR = 2.17, 95% CI = 1-4.71, P = 0.048), whilst TNF-alpha SNP decreased it, both in heterozygotes (OR = 0.20, 95% CI = 0.08-0.48, P  lt  0.001) and AA homozygotes (OR = 0.07, 95% CI = 0.01-0.37, P = 0.001). Conclusions GSTM and GSTT deletion polymorphisms, as well as TNF alpha (-308 G/A) SNP, are associated with increased risk, whereas IL-1 beta (-511 C/T) polymorphism decreases the risk of AP development. GSTT and TNF alpha polymorphisms also appear to modulate the risk of EBV infection in Serbian patients with AP.",
publisher = "Wiley, Hoboken",
journal = "International Endodontic Journal",
title = "Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?",
volume = "53",
number = "7",
pages = "895-904",
doi = "10.1111/iej.13298"
}

Jakovljević, A., Nikolić, N., Čarkić, J., Beljić-Ivanović, K., Soldatović, I., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?. in International Endodontic Journal
Wiley, Hoboken., 53(7), 895-904.
https://doi.org/10.1111/iej.13298

Jakovljević A, Nikolić N, Čarkić J, Beljić-Ivanović K, Soldatović I, Miletić M, Andrić M, Milašin J. Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?. in International Endodontic Journal. 2020;53(7):895-904.
doi:10.1111/iej.13298 .

Jakovljević, Aleksandar, Nikolić, Nadja, Čarkić, Jelena, Beljić-Ivanović, Katarina, Soldatović, Ivan, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?" in International Endodontic Journal, 53, no. 7 (2020):895-904,
https://doi.org/10.1111/iej.13298 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Miletić, Maja
AU  - Nikolić, Nadja
AU  - Beljić-Ivanović, Katarina
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2455
AB  - Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. In recent years its involvement in bone homeostasis has attracted a significant consideration. We hypothesized that Notch signaling pathway, which has a complex interplay with proinflammatory cytokines and bone resorption regulators, contributes to alveolar bone resorption via increased Notch receptors on immune cell surface and stimulates Notch receptor intracellular domain (NICD) translocation into the nucleus. The potential benefit of medications aimed to down-regulate these pathways in apical periodontitis treatment remains to be assessed.
PB  - Churchill Livingstone, Edinburgh
T2  - Medical Hypotheses
T1  - Notch signaling pathway mediates alveolar bone resorption in apical periodontitis
VL  - 124
SP  - 87
EP  - 90
DO  - 10.1016/j.mehy.2019.02.018
ER  - 

@article{
author = "Jakovljević, Aleksandar and Miletić, Maja and Nikolić, Nadja and Beljić-Ivanović, Katarina and Andrić, Miroslav and Milašin, Jelena",
year = "2019",
abstract = "Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. In recent years its involvement in bone homeostasis has attracted a significant consideration. We hypothesized that Notch signaling pathway, which has a complex interplay with proinflammatory cytokines and bone resorption regulators, contributes to alveolar bone resorption via increased Notch receptors on immune cell surface and stimulates Notch receptor intracellular domain (NICD) translocation into the nucleus. The potential benefit of medications aimed to down-regulate these pathways in apical periodontitis treatment remains to be assessed.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Medical Hypotheses",
title = "Notch signaling pathway mediates alveolar bone resorption in apical periodontitis",
volume = "124",
pages = "87-90",
doi = "10.1016/j.mehy.2019.02.018"
}

Jakovljević, A., Miletić, M., Nikolić, N., Beljić-Ivanović, K., Andrić, M.,& Milašin, J.. (2019). Notch signaling pathway mediates alveolar bone resorption in apical periodontitis. in Medical Hypotheses
Churchill Livingstone, Edinburgh., 124, 87-90.
https://doi.org/10.1016/j.mehy.2019.02.018

Jakovljević A, Miletić M, Nikolić N, Beljić-Ivanović K, Andrić M, Milašin J. Notch signaling pathway mediates alveolar bone resorption in apical periodontitis. in Medical Hypotheses. 2019;124:87-90.
doi:10.1016/j.mehy.2019.02.018 .

Jakovljević, Aleksandar, Miletić, Maja, Nikolić, Nadja, Beljić-Ivanović, Katarina, Andrić, Miroslav, Milašin, Jelena, "Notch signaling pathway mediates alveolar bone resorption in apical periodontitis" in Medical Hypotheses, 124 (2019):87-90,
https://doi.org/10.1016/j.mehy.2019.02.018 . .

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Jakovljević, Aleksandar
AU  - Čarkić, Jelena
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Soldatović, Ivan
AU  - Andrić, Miroslav
AU  - Ivanović, Vladimir
AU  - Milašin, Jelena
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2390
AB  - Introduction: The exact mechanisms of periapical bone resorption have not been fully elucidated. This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-alpha], interleukin [IL]-1 beta, and IL-6) in human apical periodontitis lesions with different receptor activator of nuclear factor kappa B ligand (RANKL)/osteo-protegerin (OPG) ratios and determine their potential correlation. Methods: The study group consisted of 50 periapical lesions collected in conjunction with apicoectomy. The relative gene expression of the investigated molecules (Notch2, Jagged1, Hey1, RANKL, OPG, TNF-alpha, IL-1 beta, and IL-6) in all tissue samples was analyzed using reverse transcriptase real-time polymerase chain reaction. The Student t test, Mann-Whitney U test and Spearman correlation were used for statistical analysis. Results: Based on the RANKUOPG ratio, periapical lesions were either RANKL predominant (RANKL > OPG, n = 33) or OPG predominant (RANKL  lt  OPG, n = 17). Symptomatic lesions occurred more frequently in RANKL-predominant compared with OPG-predominant lesions (24 vs 7, P=.029). Notch2,Jagged1, Hey1, and TNF-alpha were significantly overexpressed in lesions with predominant RANKL compared with lesions with predominant OPG (P =.001, P =.001, P =.027, and P =.016, respectively). Significant correlations were observed between the investigated genes in periapical lesions. Conclusions: Notch signaling appeared to be activated in periapical inflammation. An increase in Notch2, Jagged1, Hey1, and TNF-alpha expression in RANKL-predominant periapical lesions corroborates their joined involvement in extensive periapical bone resorption.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines
VL  - 45
IS  - 2
SP  - 123
EP  - 128
DO  - 10.1016/j.joen.2018.10.015
ER  - 

@article{
author = "Nikolić, Nadja and Jakovljević, Aleksandar and Čarkić, Jelena and Beljić-Ivanović, Katarina and Miletić, Maja and Soldatović, Ivan and Andrić, Miroslav and Ivanović, Vladimir and Milašin, Jelena",
year = "2019",
abstract = "Introduction: The exact mechanisms of periapical bone resorption have not been fully elucidated. This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-alpha], interleukin [IL]-1 beta, and IL-6) in human apical periodontitis lesions with different receptor activator of nuclear factor kappa B ligand (RANKL)/osteo-protegerin (OPG) ratios and determine their potential correlation. Methods: The study group consisted of 50 periapical lesions collected in conjunction with apicoectomy. The relative gene expression of the investigated molecules (Notch2, Jagged1, Hey1, RANKL, OPG, TNF-alpha, IL-1 beta, and IL-6) in all tissue samples was analyzed using reverse transcriptase real-time polymerase chain reaction. The Student t test, Mann-Whitney U test and Spearman correlation were used for statistical analysis. Results: Based on the RANKUOPG ratio, periapical lesions were either RANKL predominant (RANKL > OPG, n = 33) or OPG predominant (RANKL  lt  OPG, n = 17). Symptomatic lesions occurred more frequently in RANKL-predominant compared with OPG-predominant lesions (24 vs 7, P=.029). Notch2,Jagged1, Hey1, and TNF-alpha were significantly overexpressed in lesions with predominant RANKL compared with lesions with predominant OPG (P =.001, P =.001, P =.027, and P =.016, respectively). Significant correlations were observed between the investigated genes in periapical lesions. Conclusions: Notch signaling appeared to be activated in periapical inflammation. An increase in Notch2, Jagged1, Hey1, and TNF-alpha expression in RANKL-predominant periapical lesions corroborates their joined involvement in extensive periapical bone resorption.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines",
volume = "45",
number = "2",
pages = "123-128",
doi = "10.1016/j.joen.2018.10.015"
}

Nikolić, N., Jakovljević, A., Čarkić, J., Beljić-Ivanović, K., Miletić, M., Soldatović, I., Andrić, M., Ivanović, V.,& Milašin, J.. (2019). Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines. in Journal of Endodontics
Elsevier Science Inc, New York., 45(2), 123-128.
https://doi.org/10.1016/j.joen.2018.10.015

Nikolić N, Jakovljević A, Čarkić J, Beljić-Ivanović K, Miletić M, Soldatović I, Andrić M, Ivanović V, Milašin J. Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines. in Journal of Endodontics. 2019;45(2):123-128.
doi:10.1016/j.joen.2018.10.015 .

Nikolić, Nadja, Jakovljević, Aleksandar, Čarkić, Jelena, Beljić-Ivanović, Katarina, Miletić, Maja, Soldatović, Ivan, Andrić, Miroslav, Ivanović, Vladimir, Milašin, Jelena, "Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines" in Journal of Endodontics, 45, no. 2 (2019):123-128,
https://doi.org/10.1016/j.joen.2018.10.015 . .

TY  - JOUR
AU  - Stasić, Jovana
AU  - Selaković, Nenad
AU  - Puač, Nevena
AU  - Miletić, Maja
AU  - Malović, Gordana
AU  - Petrović, Zoran Lj.
AU  - Veljović, Đorđe
AU  - Miletić, Vesna
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2535
AB  - ObjectivesThe study aims to evaluate the effects of non-thermal atmospheric plasma (NTAP) treatments on dentin wetting and surface free energy (SFE) and compare the effects of NTAP treatment, etch-and-rinse, and self-etch protocols for application of universal adhesives.Materials and methodsMid-coronal dentin of intact third molars was used to measure contact angles of distilled water, ethylene-glycol, and diiodomethane and calculate SFE following different NTAP preset treatments (feeding gas consisting of pure He, He + 1% O-2, He + 1.5% O-2), power input (1 or 3W), and tip-to-surface distance (2, 4, or 8mm). Contact angles of reference liquids and SFE of dentin following He + 1.5% O-2 at 3-W and 4-mm treatment was compared to phosphoric acid etching. Contact angles of Single Bond Universal (SBU; 3M ESPE) and Clearfil Universal Bond (CUB; Kuraray Noritake) were measured following NTAP, etch-and-rinse, and self-etch protocols.ResultsNTAP significantly reduced contact angles of reference liquids and increased dentin SFE compared to untreated dentin (p lt 0.05). O-2 intensified the effect of He NTAP (p lt 0.05). NTAP and phosphoric acid increased dentin polarity and Lewis base surface characteristics. Phosphoric acid increased contact angles of adhesives compared to the self-etch protocol (p lt 0.05). NTAP resulted in lower adhesive contact angles than phosphoric acid, the difference being statistically significant for CUB (p lt 0.05). Compared to the self-etch protocol, NTAP slightly reduced CUB contact angle but not that of SBU (p>0.05).ConclusionsHe NTAP with and without O-2 increased dentin wetting and SFE, surpassing the effect of phosphoric acid and lowering adhesive contact angles. NTAP produced no apparent micro-morphological changes on dentin surface comparable to acid etching.Clinical significanceNTAP treatment of dentin prior to adhesive application increases dentin wetting and surface free energy facilitating better adhesive distribution on dentin surface compared to phosphoric acid etching and similar to the self-etch application protocol.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Effects of non-thermal atmospheric plasma treatment on dentin wetting and surface free energy for application of universal adhesives
VL  - 23
IS  - 3
SP  - 1383
EP  - 1396
DO  - 10.1007/s00784-018-2563-2
ER  - 

@article{
author = "Stasić, Jovana and Selaković, Nenad and Puač, Nevena and Miletić, Maja and Malović, Gordana and Petrović, Zoran Lj. and Veljović, Đorđe and Miletić, Vesna",
year = "2019",
abstract = "ObjectivesThe study aims to evaluate the effects of non-thermal atmospheric plasma (NTAP) treatments on dentin wetting and surface free energy (SFE) and compare the effects of NTAP treatment, etch-and-rinse, and self-etch protocols for application of universal adhesives.Materials and methodsMid-coronal dentin of intact third molars was used to measure contact angles of distilled water, ethylene-glycol, and diiodomethane and calculate SFE following different NTAP preset treatments (feeding gas consisting of pure He, He + 1% O-2, He + 1.5% O-2), power input (1 or 3W), and tip-to-surface distance (2, 4, or 8mm). Contact angles of reference liquids and SFE of dentin following He + 1.5% O-2 at 3-W and 4-mm treatment was compared to phosphoric acid etching. Contact angles of Single Bond Universal (SBU; 3M ESPE) and Clearfil Universal Bond (CUB; Kuraray Noritake) were measured following NTAP, etch-and-rinse, and self-etch protocols.ResultsNTAP significantly reduced contact angles of reference liquids and increased dentin SFE compared to untreated dentin (p lt 0.05). O-2 intensified the effect of He NTAP (p lt 0.05). NTAP and phosphoric acid increased dentin polarity and Lewis base surface characteristics. Phosphoric acid increased contact angles of adhesives compared to the self-etch protocol (p lt 0.05). NTAP resulted in lower adhesive contact angles than phosphoric acid, the difference being statistically significant for CUB (p lt 0.05). Compared to the self-etch protocol, NTAP slightly reduced CUB contact angle but not that of SBU (p>0.05).ConclusionsHe NTAP with and without O-2 increased dentin wetting and SFE, surpassing the effect of phosphoric acid and lowering adhesive contact angles. NTAP produced no apparent micro-morphological changes on dentin surface comparable to acid etching.Clinical significanceNTAP treatment of dentin prior to adhesive application increases dentin wetting and surface free energy facilitating better adhesive distribution on dentin surface compared to phosphoric acid etching and similar to the self-etch application protocol.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Effects of non-thermal atmospheric plasma treatment on dentin wetting and surface free energy for application of universal adhesives",
volume = "23",
number = "3",
pages = "1383-1396",
doi = "10.1007/s00784-018-2563-2"
}

Stasić, J., Selaković, N., Puač, N., Miletić, M., Malović, G., Petrović, Z. Lj., Veljović, Đ.,& Miletić, V.. (2019). Effects of non-thermal atmospheric plasma treatment on dentin wetting and surface free energy for application of universal adhesives. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 23(3), 1383-1396.
https://doi.org/10.1007/s00784-018-2563-2

Stasić J, Selaković N, Puač N, Miletić M, Malović G, Petrović ZL, Veljović Đ, Miletić V. Effects of non-thermal atmospheric plasma treatment on dentin wetting and surface free energy for application of universal adhesives. in Clinical Oral Investigations. 2019;23(3):1383-1396.
doi:10.1007/s00784-018-2563-2 .

Stasić, Jovana, Selaković, Nenad, Puač, Nevena, Miletić, Maja, Malović, Gordana, Petrović, Zoran Lj., Veljović, Đorđe, Miletić, Vesna, "Effects of non-thermal atmospheric plasma treatment on dentin wetting and surface free energy for application of universal adhesives" in Clinical Oral Investigations, 23, no. 3 (2019):1383-1396,
https://doi.org/10.1007/s00784-018-2563-2 . .

TY  - JOUR
AU  - Stasić, Jovana
AU  - Selaković, Nenad
AU  - Puač, Nevena
AU  - Miletić, Maja
AU  - Malović, Gordana
AU  - Petrović, Zoran Lj.
AU  - Veljović, Đorđe
AU  - Miletić, Vesna
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2389
AB  - ObjectivesThe study aims to evaluate the effects of non-thermal atmospheric plasma (NTAP) treatments on dentin wetting and surface free energy (SFE) and compare the effects of NTAP treatment, etch-and-rinse, and self-etch protocols for application of universal adhesives.Materials and methodsMid-coronal dentin of intact third molars was used to measure contact angles of distilled water, ethylene-glycol, and diiodomethane and calculate SFE following different NTAP preset treatments (feeding gas consisting of pure He, He + 1% O-2, He + 1.5% O-2), power input (1 or 3W), and tip-to-surface distance (2, 4, or 8mm). Contact angles of reference liquids and SFE of dentin following He + 1.5% O-2 at 3-W and 4-mm treatment was compared to phosphoric acid etching. Contact angles of Single Bond Universal (SBU; 3M ESPE) and Clearfil Universal Bond (CUB; Kuraray Noritake) were measured following NTAP, etch-and-rinse, and self-etch protocols.ResultsNTAP significantly reduced contact angles of reference liquids and increased dentin SFE compared to untreated dentin (p lt 0.05). O-2 intensified the effect of He NTAP (p lt 0.05). NTAP and phosphoric acid increased dentin polarity and Lewis base surface characteristics. Phosphoric acid increased contact angles of adhesives compared to the self-etch protocol (p lt 0.05). NTAP resulted in lower adhesive contact angles than phosphoric acid, the difference being statistically significant for CUB (p lt 0.05). Compared to the self-etch protocol, NTAP slightly reduced CUB contact angle but not that of SBU (p>0.05).ConclusionsHe NTAP with and without O-2 increased dentin wetting and SFE, surpassing the effect of phosphoric acid and lowering adhesive contact angles. NTAP produced no apparent micro-morphological changes on dentin surface comparable to acid etching.Clinical significanceNTAP treatment of dentin prior to adhesive application increases dentin wetting and surface free energy facilitating better adhesive distribution on dentin surface compared to phosphoric acid etching and similar to the self-etch application protocol.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Effects of non-thermal atmospheric plasma treatment on dentin wetting and surface free energy for application of universal adhesives
VL  - 23
IS  - 3
SP  - 1383
EP  - 1396
DO  - 10.1007/s00784-018-2563-2
ER  - 

@article{
author = "Stasić, Jovana and Selaković, Nenad and Puač, Nevena and Miletić, Maja and Malović, Gordana and Petrović, Zoran Lj. and Veljović, Đorđe and Miletić, Vesna",
year = "2019",
abstract = "ObjectivesThe study aims to evaluate the effects of non-thermal atmospheric plasma (NTAP) treatments on dentin wetting and surface free energy (SFE) and compare the effects of NTAP treatment, etch-and-rinse, and self-etch protocols for application of universal adhesives.Materials and methodsMid-coronal dentin of intact third molars was used to measure contact angles of distilled water, ethylene-glycol, and diiodomethane and calculate SFE following different NTAP preset treatments (feeding gas consisting of pure He, He + 1% O-2, He + 1.5% O-2), power input (1 or 3W), and tip-to-surface distance (2, 4, or 8mm). Contact angles of reference liquids and SFE of dentin following He + 1.5% O-2 at 3-W and 4-mm treatment was compared to phosphoric acid etching. Contact angles of Single Bond Universal (SBU; 3M ESPE) and Clearfil Universal Bond (CUB; Kuraray Noritake) were measured following NTAP, etch-and-rinse, and self-etch protocols.ResultsNTAP significantly reduced contact angles of reference liquids and increased dentin SFE compared to untreated dentin (p lt 0.05). O-2 intensified the effect of He NTAP (p lt 0.05). NTAP and phosphoric acid increased dentin polarity and Lewis base surface characteristics. Phosphoric acid increased contact angles of adhesives compared to the self-etch protocol (p lt 0.05). NTAP resulted in lower adhesive contact angles than phosphoric acid, the difference being statistically significant for CUB (p lt 0.05). Compared to the self-etch protocol, NTAP slightly reduced CUB contact angle but not that of SBU (p>0.05).ConclusionsHe NTAP with and without O-2 increased dentin wetting and SFE, surpassing the effect of phosphoric acid and lowering adhesive contact angles. NTAP produced no apparent micro-morphological changes on dentin surface comparable to acid etching.Clinical significanceNTAP treatment of dentin prior to adhesive application increases dentin wetting and surface free energy facilitating better adhesive distribution on dentin surface compared to phosphoric acid etching and similar to the self-etch application protocol.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Effects of non-thermal atmospheric plasma treatment on dentin wetting and surface free energy for application of universal adhesives",
volume = "23",
number = "3",
pages = "1383-1396",
doi = "10.1007/s00784-018-2563-2"
}

Stasić, J., Selaković, N., Puač, N., Miletić, M., Malović, G., Petrović, Z. Lj., Veljović, Đ.,& Miletić, V.. (2019). Effects of non-thermal atmospheric plasma treatment on dentin wetting and surface free energy for application of universal adhesives. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 23(3), 1383-1396.
https://doi.org/10.1007/s00784-018-2563-2

Stasić J, Selaković N, Puač N, Miletić M, Malović G, Petrović ZL, Veljović Đ, Miletić V. Effects of non-thermal atmospheric plasma treatment on dentin wetting and surface free energy for application of universal adhesives. in Clinical Oral Investigations. 2019;23(3):1383-1396.
doi:10.1007/s00784-018-2563-2 .

Stasić, Jovana, Selaković, Nenad, Puač, Nevena, Miletić, Maja, Malović, Gordana, Petrović, Zoran Lj., Veljović, Đorđe, Miletić, Vesna, "Effects of non-thermal atmospheric plasma treatment on dentin wetting and surface free energy for application of universal adhesives" in Clinical Oral Investigations, 23, no. 3 (2019):1383-1396,
https://doi.org/10.1007/s00784-018-2563-2 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Milašin, Jelena
AU  - Sabeti, Mohammad
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2595
AB  - Purpose of Review
This review describes the most recent findings on herpesviral infections and offers current concepts of herpesviral role in the pathogenesis of periapical periodontitis.

Recent Findings
Thirty articles reported data on herpesviral infection in periapical periodontitis. Epstein-Barr virus and human cytomegalovirus are the most frequently detected herpesviruses in periapical samples. The main hypothesis postulates a bidirectional herpesviral-bacterial relationship in the etiopathogenesis of periapical periodontitis. A high heterogeneity of herpesviruses incidence was registered within the studies, in part, due to various methodological approaches used in laboratory testing, different inclusion criteria, study design, seroprevalence of herpesviruses, and sociodemographic characteristics of investigated populations.

Summary
Herpesviruses have been shown to potentially impair local host defense in periapical tissue. Although it has been demonstrated that endodontic pathogenic bacteria are able to reactivate herpesviruses, further, in vitro studies should provide more data on herpesviruses as a factor in the pathogenesis of the periapical pathoses. It is, therefore, necessary to investigate potential benefits of antiviral therapy in well-designed controlled longitudinal studies.
PB  - Springer
T2  - Current Oral Health Reports
T1  - Herpesviral Infection in Periapical Periodontitis
VL  - 5
IS  - 4
SP  - 255
EP  - 263
DO  - 10.1007/s40496-018-0198-7
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Miletić, Maja and Beljić-Ivanović, Katarina and Milašin, Jelena and Sabeti, Mohammad",
year = "2018",
abstract = "Purpose of Review
This review describes the most recent findings on herpesviral infections and offers current concepts of herpesviral role in the pathogenesis of periapical periodontitis.

Recent Findings
Thirty articles reported data on herpesviral infection in periapical periodontitis. Epstein-Barr virus and human cytomegalovirus are the most frequently detected herpesviruses in periapical samples. The main hypothesis postulates a bidirectional herpesviral-bacterial relationship in the etiopathogenesis of periapical periodontitis. A high heterogeneity of herpesviruses incidence was registered within the studies, in part, due to various methodological approaches used in laboratory testing, different inclusion criteria, study design, seroprevalence of herpesviruses, and sociodemographic characteristics of investigated populations.

Summary
Herpesviruses have been shown to potentially impair local host defense in periapical tissue. Although it has been demonstrated that endodontic pathogenic bacteria are able to reactivate herpesviruses, further, in vitro studies should provide more data on herpesviruses as a factor in the pathogenesis of the periapical pathoses. It is, therefore, necessary to investigate potential benefits of antiviral therapy in well-designed controlled longitudinal studies.",
publisher = "Springer",
journal = "Current Oral Health Reports",
title = "Herpesviral Infection in Periapical Periodontitis",
volume = "5",
number = "4",
pages = "255-263",
doi = "10.1007/s40496-018-0198-7"
}

Jakovljević, A., Andrić, M., Knežević, A., Miletić, M., Beljić-Ivanović, K., Milašin, J.,& Sabeti, M.. (2018). Herpesviral Infection in Periapical Periodontitis. in Current Oral Health Reports
Springer., 5(4), 255-263.
https://doi.org/10.1007/s40496-018-0198-7

Jakovljević A, Andrić M, Knežević A, Miletić M, Beljić-Ivanović K, Milašin J, Sabeti M. Herpesviral Infection in Periapical Periodontitis. in Current Oral Health Reports. 2018;5(4):255-263.
doi:10.1007/s40496-018-0198-7 .

Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Miletić, Maja, Beljić-Ivanović, Katarina, Milašin, Jelena, Sabeti, Mohammad, "Herpesviral Infection in Periapical Periodontitis" in Current Oral Health Reports, 5, no. 4 (2018):255-263,
https://doi.org/10.1007/s40496-018-0198-7 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Nikolić, Nadja
AU  - Corić, V.
AU  - Krezović, S.
AU  - Čarkić, Jelena
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Pljesa-Ercegovac, M.
AU  - Miletić, Maja
AU  - Soldatović, Ivan
AU  - Radosavljević, T.
AU  - Jovanović, T.
AU  - Simić, T.
AU  - Ivanović, Vladimir
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2293
AB  - AimTo investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] and bone resorption regulators [receptor activator of nuclear factor (NF-B) ligand (RANKL) and osteoprotegerin (OPG)] compared to EBV-negative periapical lesions and healthy pulp tissues. MethodologyThe experimental group consisted of 30 EBV-positive and 30 EBV-negative periapical lesions collected in conjunction with apicoectomy. The pulp tissues of 20 impacted third molars were used as healthy controls. The qualitative and quantitative analysis of EBV was performed by nested and real-time polymerase chain reaction (PCR), respectively. The levels of RANKL and OPG were analysed by reverse transcriptase real-time PCR. The levels of 8-OHdG and GSSG were determined by enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U-test and Spearman's correlation were used for statistical analysis. ResultsThe levels of RANKL, OPG, 8-OHdG and GSSG were significantly higher in apical periodontitis lesions compared to healthy pulp controls (P=0.001, P lt 0.001, P lt 0.001 and P lt 0.05, respectively). RANKL and OPG mRNA expression was significantly higher in EBV-positive compared to EBV-negative periapical lesions (P lt 0.05). There was no significant correlation between EBV copy numbers and levels of RANKL, OPG, 8OH-dG and GSSG in apical periodontitis. ConclusionLevels of bone resorption regulators and oxidative stress biomarkers were increased in apical periodontitis compared to healthy pulp tissues. EBV-positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV-negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.
PB  - Wiley, Hoboken
T2  - International Endodontic Journal
T1  - Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus
VL  - 51
IS  - 6
SP  - 593
EP  - 604
DO  - 10.1111/iej.12886
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Nikolić, Nadja and Corić, V. and Krezović, S. and Čarkić, Jelena and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Pljesa-Ercegovac, M. and Miletić, Maja and Soldatović, Ivan and Radosavljević, T. and Jovanović, T. and Simić, T. and Ivanović, Vladimir and Milašin, Jelena",
year = "2018",
abstract = "AimTo investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] and bone resorption regulators [receptor activator of nuclear factor (NF-B) ligand (RANKL) and osteoprotegerin (OPG)] compared to EBV-negative periapical lesions and healthy pulp tissues. MethodologyThe experimental group consisted of 30 EBV-positive and 30 EBV-negative periapical lesions collected in conjunction with apicoectomy. The pulp tissues of 20 impacted third molars were used as healthy controls. The qualitative and quantitative analysis of EBV was performed by nested and real-time polymerase chain reaction (PCR), respectively. The levels of RANKL and OPG were analysed by reverse transcriptase real-time PCR. The levels of 8-OHdG and GSSG were determined by enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U-test and Spearman's correlation were used for statistical analysis. ResultsThe levels of RANKL, OPG, 8-OHdG and GSSG were significantly higher in apical periodontitis lesions compared to healthy pulp controls (P=0.001, P lt 0.001, P lt 0.001 and P lt 0.05, respectively). RANKL and OPG mRNA expression was significantly higher in EBV-positive compared to EBV-negative periapical lesions (P lt 0.05). There was no significant correlation between EBV copy numbers and levels of RANKL, OPG, 8OH-dG and GSSG in apical periodontitis. ConclusionLevels of bone resorption regulators and oxidative stress biomarkers were increased in apical periodontitis compared to healthy pulp tissues. EBV-positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV-negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.",
publisher = "Wiley, Hoboken",
journal = "International Endodontic Journal",
title = "Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus",
volume = "51",
number = "6",
pages = "593-604",
doi = "10.1111/iej.12886"
}

Jakovljević, A., Andrić, M., Nikolić, N., Corić, V., Krezović, S., Čarkić, J., Knežević, A., Beljić-Ivanović, K., Pljesa-Ercegovac, M., Miletić, M., Soldatović, I., Radosavljević, T., Jovanović, T., Simić, T., Ivanović, V.,& Milašin, J.. (2018). Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. in International Endodontic Journal
Wiley, Hoboken., 51(6), 593-604.
https://doi.org/10.1111/iej.12886

Jakovljević A, Andrić M, Nikolić N, Corić V, Krezović S, Čarkić J, Knežević A, Beljić-Ivanović K, Pljesa-Ercegovac M, Miletić M, Soldatović I, Radosavljević T, Jovanović T, Simić T, Ivanović V, Milašin J. Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. in International Endodontic Journal. 2018;51(6):593-604.
doi:10.1111/iej.12886 .

Jakovljević, Aleksandar, Andrić, Miroslav, Nikolić, Nadja, Corić, V., Krezović, S., Čarkić, Jelena, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Pljesa-Ercegovac, M., Miletić, Maja, Soldatović, Ivan, Radosavljević, T., Jovanović, T., Simić, T., Ivanović, Vladimir, Milašin, Jelena, "Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus" in International Endodontic Journal, 51, no. 6 (2018):593-604,
https://doi.org/10.1111/iej.12886 . .

TY  - JOUR
AU  - Vučević, Danijela
AU  - Radak, Đorđe
AU  - Đorđević, Drago
AU  - Miletić, Maja
AU  - Jakovljević, Aleksandar
AU  - Jorgačević, Bojan
AU  - Vesković, Milena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2584
AB  - The pathogenesis of obesity-related vascular disorders has not been fully elucidated. The fundamental role of inflammation in aging process is now widely recognized, particularly for atherosclerotic disease which begins before birth. The number of obese individuals worldwide has reached two billion, leading to an explosion of obesity-related vascular disorders associated with increased morbidity and mortality. Obesity, as a chronic low grade inflammatory process, is important risk factor for metabolic and cardiovascular disease. Despite a well-known genetic component, this risk appears to originate from several abnormalities in adipose tissue function associated with a chronic inflammatory state. In particular, obesity as the most common nutritional disorder in industrialized countries, is closely related to impaired endothelial function, a well-known marker of preatherosclerotic disease. These conditions disrupt vascular homeostasis by causing an imbalance between the nitric oxide pathway and the endothelin-1 system, with impaired insulin- stimulated endothelium-dependent vasodilation. Having in mind the growing population of overweight and obese people worldwide, along with an increasingly aging population, understanding the pathophysiology of obesity on cardiovascular system is essential. The mechanisms linking obesity-related vascular disorders and low grade inflammation in aging process are the focus of this paper.
AB  - Patogeneza vaskularnih poremećaja koji su povezani sa gojaznošću nije u potpunosti razjašnjena. Danas je poznata fundamentalna uloga inflamacije u procesu starenja, naročito kod aterosklerozne bolesti, koja počinje pre rođenja. Broj gojaznih osoba širom sveta je dostigao cifru dva biliona i doveo do “eksplozije” vaskularnih poremećaja koji su povezani sa gojaznošću i povećanim morbiditetom i mortalitetom. Gojaznost, kao hronični niskostepeni inflamacijski proces, je važan faktor rizika za nastanak metaboličkih i kardiovaskularnih bolesti. Pored dobro proučene genetske komponente, izgleda da je za ovaj rizik zaslužno i nekoliko poremećaja funkcije masnog tkiva koji se dovode u vezu sa stanjem hronične inflamacije. U tom smislu prednjači gojaznost, pošto je kao najčešći poremećaj ishrane u razvijenim zemljama blisko povezana sa endotelnom disfunkcijom, koja predstavlja uveliko poznat marker preaterosklerozne bolesti. Takvi uslovi narušavaju vaskularnu homeostazu, dovodeći do dizbalansa između metaboličkog puta azot monoksida i sistema endotelina-1, što je praćeno otežanim odvijanjem insulinom podstaknute vazodilatacije. Imajući u vidu globalni zajednički porast broja kako osoba sa viškom kilograma i gojaznih osoba, tako i starije populacije, razumevanje patogeneze gojaznosti i njenog uticaja na kardiovaskularni sistem je od esencijalnog značaja. Mehanizmi koji čine sponu između vaskularnih poremećaja povezanih sa gojaznošću i niskostepene inflamacije u procesu starenja nalaze se u fokusu ovog rada.
PB  - Medicinski fakultet Univerziteta U Beogradu
T2  - Medicinska istraživanja
T1  - Chronic low grade inflammation in aging process as a link on a chain of obesity - related vascular disorders
T1  - Hronična niskostepena inflamacija u procesu starenja kao karika u lancu vaskularnih poremećaja koji su povezani sa gojaznošću
VL  - 52
IS  - 1
SP  - 32
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_smile_2584
ER  - 

@article{
author = "Vučević, Danijela and Radak, Đorđe and Đorđević, Drago and Miletić, Maja and Jakovljević, Aleksandar and Jorgačević, Bojan and Vesković, Milena",
year = "2018",
abstract = "The pathogenesis of obesity-related vascular disorders has not been fully elucidated. The fundamental role of inflammation in aging process is now widely recognized, particularly for atherosclerotic disease which begins before birth. The number of obese individuals worldwide has reached two billion, leading to an explosion of obesity-related vascular disorders associated with increased morbidity and mortality. Obesity, as a chronic low grade inflammatory process, is important risk factor for metabolic and cardiovascular disease. Despite a well-known genetic component, this risk appears to originate from several abnormalities in adipose tissue function associated with a chronic inflammatory state. In particular, obesity as the most common nutritional disorder in industrialized countries, is closely related to impaired endothelial function, a well-known marker of preatherosclerotic disease. These conditions disrupt vascular homeostasis by causing an imbalance between the nitric oxide pathway and the endothelin-1 system, with impaired insulin- stimulated endothelium-dependent vasodilation. Having in mind the growing population of overweight and obese people worldwide, along with an increasingly aging population, understanding the pathophysiology of obesity on cardiovascular system is essential. The mechanisms linking obesity-related vascular disorders and low grade inflammation in aging process are the focus of this paper., Patogeneza vaskularnih poremećaja koji su povezani sa gojaznošću nije u potpunosti razjašnjena. Danas je poznata fundamentalna uloga inflamacije u procesu starenja, naročito kod aterosklerozne bolesti, koja počinje pre rođenja. Broj gojaznih osoba širom sveta je dostigao cifru dva biliona i doveo do “eksplozije” vaskularnih poremećaja koji su povezani sa gojaznošću i povećanim morbiditetom i mortalitetom. Gojaznost, kao hronični niskostepeni inflamacijski proces, je važan faktor rizika za nastanak metaboličkih i kardiovaskularnih bolesti. Pored dobro proučene genetske komponente, izgleda da je za ovaj rizik zaslužno i nekoliko poremećaja funkcije masnog tkiva koji se dovode u vezu sa stanjem hronične inflamacije. U tom smislu prednjači gojaznost, pošto je kao najčešći poremećaj ishrane u razvijenim zemljama blisko povezana sa endotelnom disfunkcijom, koja predstavlja uveliko poznat marker preaterosklerozne bolesti. Takvi uslovi narušavaju vaskularnu homeostazu, dovodeći do dizbalansa između metaboličkog puta azot monoksida i sistema endotelina-1, što je praćeno otežanim odvijanjem insulinom podstaknute vazodilatacije. Imajući u vidu globalni zajednički porast broja kako osoba sa viškom kilograma i gojaznih osoba, tako i starije populacije, razumevanje patogeneze gojaznosti i njenog uticaja na kardiovaskularni sistem je od esencijalnog značaja. Mehanizmi koji čine sponu između vaskularnih poremećaja povezanih sa gojaznošću i niskostepene inflamacije u procesu starenja nalaze se u fokusu ovog rada.",
publisher = "Medicinski fakultet Univerziteta U Beogradu",
journal = "Medicinska istraživanja",
title = "Chronic low grade inflammation in aging process as a link on a chain of obesity - related vascular disorders, Hronična niskostepena inflamacija u procesu starenja kao karika u lancu vaskularnih poremećaja koji su povezani sa gojaznošću",
volume = "52",
number = "1",
pages = "32-42",
url = "https://hdl.handle.net/21.15107/rcub_smile_2584"
}

Vučević, D., Radak, Đ., Đorđević, D., Miletić, M., Jakovljević, A., Jorgačević, B.,& Vesković, M.. (2018). Chronic low grade inflammation in aging process as a link on a chain of obesity - related vascular disorders. in Medicinska istraživanja
Medicinski fakultet Univerziteta U Beogradu., 52(1), 32-42.
https://hdl.handle.net/21.15107/rcub_smile_2584

Vučević D, Radak Đ, Đorđević D, Miletić M, Jakovljević A, Jorgačević B, Vesković M. Chronic low grade inflammation in aging process as a link on a chain of obesity - related vascular disorders. in Medicinska istraživanja. 2018;52(1):32-42.
https://hdl.handle.net/21.15107/rcub_smile_2584 .

Vučević, Danijela, Radak, Đorđe, Đorđević, Drago, Miletić, Maja, Jakovljević, Aleksandar, Jorgačević, Bojan, Vesković, Milena, "Chronic low grade inflammation in aging process as a link on a chain of obesity - related vascular disorders" in Medicinska istraživanja, 52, no. 1 (2018):32-42,
https://hdl.handle.net/21.15107/rcub_smile_2584 .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Kuzmanović, Jovana
AU  - Dragan, Irina E.
AU  - Knežević, Aleksandra
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2223
AB  - Introduction: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies. Methods: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus. A qualitative critical appraisal of the included articles was performed. Results: The electronic database search. yielded 66 hits from PubMed, 73 hits from Web of Science, and 107 from Scopus: Seven case reports and 3 cross-sectional studies were included in the final review. When summarized, in 7 patients with a history of a previous HZ attack and with no other apparent cause, -23 teeth were diagnosed with apical periodontitis, 8 teeth with internal and 1 tooth with external root resorption. The cross-sectional studies investigated the presence of VZV DNA in samples of acute apical abscess. The VZV DNA was found only in 2 of 65 samples. Conclusions: All studies included in this systematic review.had a low level of evidence (4 and 5). Still, the potential role of VZV in the etiopathogenesis of periapical pathoses and root resorption cannot be ruled out. Future investigations should be directed toward the analysis of VZV pathologic effects on pulp blood vessels, which might cause local ischemia and tissue necrosis.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review
VL  - 43
IS  - 8
SP  - 1230
EP  - 1236
DO  - 10.1016/j.joen.2017.04.021
ER  - 

@article{
author = "Jakovljević, Aleksandar and Kuzmanović, Jovana and Dragan, Irina E. and Knežević, Aleksandra and Miletić, Maja and Beljić-Ivanović, Katarina and Milašin, Jelena and Andrić, Miroslav",
year = "2017",
abstract = "Introduction: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies. Methods: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus. A qualitative critical appraisal of the included articles was performed. Results: The electronic database search. yielded 66 hits from PubMed, 73 hits from Web of Science, and 107 from Scopus: Seven case reports and 3 cross-sectional studies were included in the final review. When summarized, in 7 patients with a history of a previous HZ attack and with no other apparent cause, -23 teeth were diagnosed with apical periodontitis, 8 teeth with internal and 1 tooth with external root resorption. The cross-sectional studies investigated the presence of VZV DNA in samples of acute apical abscess. The VZV DNA was found only in 2 of 65 samples. Conclusions: All studies included in this systematic review.had a low level of evidence (4 and 5). Still, the potential role of VZV in the etiopathogenesis of periapical pathoses and root resorption cannot be ruled out. Future investigations should be directed toward the analysis of VZV pathologic effects on pulp blood vessels, which might cause local ischemia and tissue necrosis.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review",
volume = "43",
number = "8",
pages = "1230-1236",
doi = "10.1016/j.joen.2017.04.021"
}

Jakovljević, A., Kuzmanović, J., Dragan, I. E., Knežević, A., Miletić, M., Beljić-Ivanović, K., Milašin, J.,& Andrić, M.. (2017). The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review. in Journal of Endodontics
Elsevier Science Inc, New York., 43(8), 1230-1236.
https://doi.org/10.1016/j.joen.2017.04.021

Jakovljević A, Kuzmanović J, Dragan IE, Knežević A, Miletić M, Beljić-Ivanović K, Milašin J, Andrić M. The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review. in Journal of Endodontics. 2017;43(8):1230-1236.
doi:10.1016/j.joen.2017.04.021 .

Jakovljević, Aleksandar, Kuzmanović, Jovana, Dragan, Irina E., Knežević, Aleksandra, Miletić, Maja, Beljić-Ivanović, Katarina, Milašin, Jelena, Andrić, Miroslav, "The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review" in Journal of Endodontics, 43, no. 8 (2017):1230-1236,
https://doi.org/10.1016/j.joen.2017.04.021 . .

TY  - CHAP
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Jovanović, Tanja
AU  - Kesić, Ljiljana
AU  - Milasin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2597
AB  - Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.
PB  - Rijeka : InTech
T2  - Herpesviridae
T1  - Herpesviruses in Periapical Pathoses: An Updated Systematic Review
SP  - 31
EP  - 74
DO  - 10.5772/64004
ER  - 

@inbook{
editor = "Ongrádi, Joseph",
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Miletić, Maja and Jovanović, Tanja and Kesić, Ljiljana and Milasin, Jelena",
year = "2016",
abstract = "Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.",
publisher = "Rijeka : InTech",
journal = "Herpesviridae",
booktitle = "Herpesviruses in Periapical Pathoses: An Updated Systematic Review",
pages = "31-74",
doi = "10.5772/64004"
}

Ongrádi, J., Jakovljević, A., Andrić, M., Knežević, A., Beljić-Ivanović, K., Miletić, M., Jovanović, T., Kesić, L.,& Milasin, J.. (2016). Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae
Rijeka : InTech., 31-74.
https://doi.org/10.5772/64004

Ongrádi J, Jakovljević A, Andrić M, Knežević A, Beljić-Ivanović K, Miletić M, Jovanović T, Kesić L, Milasin J. Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae. 2016;:31-74.
doi:10.5772/64004 .

Ongrádi, Joseph, Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Miletić, Maja, Jovanović, Tanja, Kesić, Ljiljana, Milasin, Jelena, "Herpesviruses in Periapical Pathoses: An Updated Systematic Review" in Herpesviridae (2016):31-74,
https://doi.org/10.5772/64004 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Knežević, Aleksandra
AU  - Mojsilović, Slavko
AU  - Milašin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2147
AB  - Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.
PB  - Churchill Livingstone, Edinburgh
T2  - Medical Hypotheses
T1  - Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species
VL  - 94
SP  - 40
EP  - 42
DO  - 10.1016/j.mehy.2016.06.020
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Miletić, Maja and Beljić-Ivanović, Katarina and Knežević, Aleksandra and Mojsilović, Slavko and Milašin, Jelena",
year = "2016",
abstract = "Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Medical Hypotheses",
title = "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species",
volume = "94",
pages = "40-42",
doi = "10.1016/j.mehy.2016.06.020"
}

Jakovljević, A., Andrić, M., Miletić, M., Beljić-Ivanović, K., Knežević, A., Mojsilović, S.,& Milašin, J.. (2016). Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses
Churchill Livingstone, Edinburgh., 94, 40-42.
https://doi.org/10.1016/j.mehy.2016.06.020

Jakovljević A, Andrić M, Miletić M, Beljić-Ivanović K, Knežević A, Mojsilović S, Milašin J. Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses. 2016;94:40-42.
doi:10.1016/j.mehy.2016.06.020 .

Jakovljević, Aleksandar, Andrić, Miroslav, Miletić, Maja, Beljić-Ivanović, Katarina, Knežević, Aleksandra, Mojsilović, Slavko, Milašin, Jelena, "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species" in Medical Hypotheses, 94 (2016):40-42,
https://doi.org/10.1016/j.mehy.2016.06.020 . .

TY  - JOUR
AU  - Puač, Nevena
AU  - Miletić, Maja
AU  - Mojović, Miloš
AU  - Popović-Bijelić, Ana
AU  - Vuković, Dragana
AU  - Miličić, Biljana
AU  - Maletić, Dejan
AU  - Lazović, Saša
AU  - Malović, Gordana
AU  - Petrović, Zoran Lj.
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1966
AB  - In this paper we will present results for plasma sterilization of planktonic samples of two reference strains of bacteria, Pseudomonas aeruginosa ATCC 27853 and Enterococcus faecalis ATCC 29212. We have used a plasma needle as a source of non-equilibrium atmospheric plasma in all treatments. This device is already well characterized by OES, derivative probes and mass spectrometry. It was shown that power delivered to the plasma is bellow 2 W and that it produces the main radical oxygen and nitrogen species believed to be responsible for the sterilization process. Here we will only present results obtained by electron paramagnetic resonance which was used to detect the OH, H and NO species. Treatment time and power delivered to the plasma were found to have the strongest influence on sterilization. In all cases we have observed a reduction of several orders of magnitude in the concentration of bacteria and for the longest treatment time complete eradication. A more efficient sterilization was achieved in the case of gram negative bacteria.
PB  - De Gruyter Open Ltd, Warsaw
T2  - Open Chemistry
T1  - Sterilization of bacteria suspensions and identification of radicals deposited during plasma treatment
VL  - 13
IS  - 1
SP  - 332
EP  - 338
DO  - 10.1515/chem-2015-0041
ER  - 

@article{
author = "Puač, Nevena and Miletić, Maja and Mojović, Miloš and Popović-Bijelić, Ana and Vuković, Dragana and Miličić, Biljana and Maletić, Dejan and Lazović, Saša and Malović, Gordana and Petrović, Zoran Lj.",
year = "2015",
abstract = "In this paper we will present results for plasma sterilization of planktonic samples of two reference strains of bacteria, Pseudomonas aeruginosa ATCC 27853 and Enterococcus faecalis ATCC 29212. We have used a plasma needle as a source of non-equilibrium atmospheric plasma in all treatments. This device is already well characterized by OES, derivative probes and mass spectrometry. It was shown that power delivered to the plasma is bellow 2 W and that it produces the main radical oxygen and nitrogen species believed to be responsible for the sterilization process. Here we will only present results obtained by electron paramagnetic resonance which was used to detect the OH, H and NO species. Treatment time and power delivered to the plasma were found to have the strongest influence on sterilization. In all cases we have observed a reduction of several orders of magnitude in the concentration of bacteria and for the longest treatment time complete eradication. A more efficient sterilization was achieved in the case of gram negative bacteria.",
publisher = "De Gruyter Open Ltd, Warsaw",
journal = "Open Chemistry",
title = "Sterilization of bacteria suspensions and identification of radicals deposited during plasma treatment",
volume = "13",
number = "1",
pages = "332-338",
doi = "10.1515/chem-2015-0041"
}

Puač, N., Miletić, M., Mojović, M., Popović-Bijelić, A., Vuković, D., Miličić, B., Maletić, D., Lazović, S., Malović, G.,& Petrović, Z. Lj.. (2015). Sterilization of bacteria suspensions and identification of radicals deposited during plasma treatment. in Open Chemistry
De Gruyter Open Ltd, Warsaw., 13(1), 332-338.
https://doi.org/10.1515/chem-2015-0041

Puač N, Miletić M, Mojović M, Popović-Bijelić A, Vuković D, Miličić B, Maletić D, Lazović S, Malović G, Petrović ZL. Sterilization of bacteria suspensions and identification of radicals deposited during plasma treatment. in Open Chemistry. 2015;13(1):332-338.
doi:10.1515/chem-2015-0041 .

Puač, Nevena, Miletić, Maja, Mojović, Miloš, Popović-Bijelić, Ana, Vuković, Dragana, Miličić, Biljana, Maletić, Dejan, Lazović, Saša, Malović, Gordana, Petrović, Zoran Lj., "Sterilization of bacteria suspensions and identification of radicals deposited during plasma treatment" in Open Chemistry, 13, no. 1 (2015):332-338,
https://doi.org/10.1515/chem-2015-0041 . .

TY  - JOUR
AU  - Miletić, Maja
AU  - Mojsilović, S.
AU  - Okic-Đorđević, Ivana
AU  - Kukolj, Tamara
AU  - Jauković, Aleksandra
AU  - Santibanez, J. F.
AU  - Jovcić, Gordana
AU  - Bugarski, Diana
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1951
AB  - Mesenchymal stem cells (MSCs) were isolated from human periodontal ligament (hPDL-MSCs) and characterized by their morphology, clonogenic efficiency, proliferation and differentiation capabilities. hPDL-MSCs, derived from normal impacted third molars, possessed all of the properties of MSC, including clonogenic ability, high proliferation rate and multi-lineage (osteogenic, chondrogenic, adipogenic, myogenic) differentiation potential. Moreover, hPDL-MSCs expressed a typical MSC epitope profile, being positive for mesenchymal cell markers (CD44H, CD90, CD105, CD73, CD29, Stro-1, fibronectin, vimentin, alpha-SMA), and negative for hematopoietic stem cell markers (CD34, CD11b, CD45, Glycophorin-CD235a). Additionally, hPDL-MSCs, as primitive and highly multipotent cells, showed high expression of embryonic markers (Nanog, Sox2, SSEA4). The data obtained provided yet further proof that cells with mesenchymal properties can be obtained from periodontal ligament tissue. Although these cells should be further investigated to determine their clinical significance, hPDL-MSCs are believed to provide a renewable and promising cell source for new therapeutic strategies in the treatment of periodontal defects.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Mesenchymal stem cells isolated from human periodontal ligament
VL  - 66
IS  - 1
SP  - 261
EP  - 271
DO  - 10.2298/ABS1401261M
ER  - 

@article{
author = "Miletić, Maja and Mojsilović, S. and Okic-Đorđević, Ivana and Kukolj, Tamara and Jauković, Aleksandra and Santibanez, J. F. and Jovcić, Gordana and Bugarski, Diana",
year = "2014",
abstract = "Mesenchymal stem cells (MSCs) were isolated from human periodontal ligament (hPDL-MSCs) and characterized by their morphology, clonogenic efficiency, proliferation and differentiation capabilities. hPDL-MSCs, derived from normal impacted third molars, possessed all of the properties of MSC, including clonogenic ability, high proliferation rate and multi-lineage (osteogenic, chondrogenic, adipogenic, myogenic) differentiation potential. Moreover, hPDL-MSCs expressed a typical MSC epitope profile, being positive for mesenchymal cell markers (CD44H, CD90, CD105, CD73, CD29, Stro-1, fibronectin, vimentin, alpha-SMA), and negative for hematopoietic stem cell markers (CD34, CD11b, CD45, Glycophorin-CD235a). Additionally, hPDL-MSCs, as primitive and highly multipotent cells, showed high expression of embryonic markers (Nanog, Sox2, SSEA4). The data obtained provided yet further proof that cells with mesenchymal properties can be obtained from periodontal ligament tissue. Although these cells should be further investigated to determine their clinical significance, hPDL-MSCs are believed to provide a renewable and promising cell source for new therapeutic strategies in the treatment of periodontal defects.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Mesenchymal stem cells isolated from human periodontal ligament",
volume = "66",
number = "1",
pages = "261-271",
doi = "10.2298/ABS1401261M"
}

Miletić, M., Mojsilović, S., Okic-Đorđević, I., Kukolj, T., Jauković, A., Santibanez, J. F., Jovcić, G.,& Bugarski, D.. (2014). Mesenchymal stem cells isolated from human periodontal ligament. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 66(1), 261-271.
https://doi.org/10.2298/ABS1401261M

Miletić M, Mojsilović S, Okic-Đorđević I, Kukolj T, Jauković A, Santibanez JF, Jovcić G, Bugarski D. Mesenchymal stem cells isolated from human periodontal ligament. in Archives of Biological Sciences. 2014;66(1):261-271.
doi:10.2298/ABS1401261M .

Miletić, Maja, Mojsilović, S., Okic-Đorđević, Ivana, Kukolj, Tamara, Jauković, Aleksandra, Santibanez, J. F., Jovcić, Gordana, Bugarski, Diana, "Mesenchymal stem cells isolated from human periodontal ligament" in Archives of Biological Sciences, 66, no. 1 (2014):261-271,
https://doi.org/10.2298/ABS1401261M . .

TY  - JOUR
AU  - Miletić, Maja
AU  - Vuković, Dragana
AU  - Zivanović, Irena
AU  - Dakić, Ivana
AU  - Soldatović, Ivan
AU  - Maletić, Dejan
AU  - Lazović, Saša
AU  - Malović, Gordana
AU  - Petrović, Zoran Lj.
AU  - Puač, Nevena
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1947
AB  - In numerous recent papers plasma chemistry of non equilibrium plasma sources operating at atmospheric pressure has been linked to plasma medical effects including sterilization. In this paper we present a study of the effectiveness of an atmospheric pressure plasma source, known as plasma needle, in inhibition of the growth of biofilm produced by methicillin resistant Staphylococcus aureus (MRSA). Even at the lowest powers the biofilms formed by inoculi of MRSA of 10(4) and 10(5) CFU have been strongly affected by plasma and growth in biofilms was inhibited. The eradication of the already formed biofilm was not achieved and it is required to go to more effective sources.
PB  - De Gruyter Open Ltd, Warsaw
T2  - Central European Journal of Physics
T1  - Inhibition of methicillin resistant Staphylococcus aureus by a plasma needle
VL  - 12
IS  - 3
SP  - 160
EP  - 167
DO  - 10.2478/s11534-014-0437-z
ER  - 

@article{
author = "Miletić, Maja and Vuković, Dragana and Zivanović, Irena and Dakić, Ivana and Soldatović, Ivan and Maletić, Dejan and Lazović, Saša and Malović, Gordana and Petrović, Zoran Lj. and Puač, Nevena",
year = "2014",
abstract = "In numerous recent papers plasma chemistry of non equilibrium plasma sources operating at atmospheric pressure has been linked to plasma medical effects including sterilization. In this paper we present a study of the effectiveness of an atmospheric pressure plasma source, known as plasma needle, in inhibition of the growth of biofilm produced by methicillin resistant Staphylococcus aureus (MRSA). Even at the lowest powers the biofilms formed by inoculi of MRSA of 10(4) and 10(5) CFU have been strongly affected by plasma and growth in biofilms was inhibited. The eradication of the already formed biofilm was not achieved and it is required to go to more effective sources.",
publisher = "De Gruyter Open Ltd, Warsaw",
journal = "Central European Journal of Physics",
title = "Inhibition of methicillin resistant Staphylococcus aureus by a plasma needle",
volume = "12",
number = "3",
pages = "160-167",
doi = "10.2478/s11534-014-0437-z"
}

Miletić, M., Vuković, D., Zivanović, I., Dakić, I., Soldatović, I., Maletić, D., Lazović, S., Malović, G., Petrović, Z. Lj.,& Puač, N.. (2014). Inhibition of methicillin resistant Staphylococcus aureus by a plasma needle. in Central European Journal of Physics
De Gruyter Open Ltd, Warsaw., 12(3), 160-167.
https://doi.org/10.2478/s11534-014-0437-z

Miletić M, Vuković D, Zivanović I, Dakić I, Soldatović I, Maletić D, Lazović S, Malović G, Petrović ZL, Puač N. Inhibition of methicillin resistant Staphylococcus aureus by a plasma needle. in Central European Journal of Physics. 2014;12(3):160-167.
doi:10.2478/s11534-014-0437-z .

Miletić, Maja, Vuković, Dragana, Zivanović, Irena, Dakić, Ivana, Soldatović, Ivan, Maletić, Dejan, Lazović, Saša, Malović, Gordana, Petrović, Zoran Lj., Puač, Nevena, "Inhibition of methicillin resistant Staphylococcus aureus by a plasma needle" in Central European Journal of Physics, 12, no. 3 (2014):160-167,
https://doi.org/10.2478/s11534-014-0437-z . .

TY  - JOUR
AU  - Miletić, Maja
AU  - Mojsilović, S.
AU  - Okic-Đorđević, Ivana
AU  - Maletić, D.
AU  - Puač, Nevena
AU  - Lazović, Saša
AU  - Malović, Gordana
AU  - Milenković, P.
AU  - Petrović, Zoran Lj.
AU  - Bugarski, Diana
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1833
AB  - Here we investigate the influences of non-thermal atmospheric plasma on human mesenchymal stem cells isolated from periodontal ligament (hPDL-MSCs). A specially redesigned plasma needle was used as the source of low-temperature plasma and its effects on different hPDL-MSC functions were investigated. Cell cultures were obtained from extracted normal impacted third molars and characterized for their phenotype and multi-potential differentiation. The hPDL-MSCs possessed all the typical MSC properties, including clonogenic ability, high proliferation rate, specific phenotype and multilineage differentiation. The data regarding the interaction of plasma with hPDL-MSCs demonstrated that plasma treatment inhibited the migration of hPDL-MSCs and induced some detachment, while not affecting their viability. Additionally, plasma significantly attenuated hPDL-MSCs' proliferation, but promoted their osteogenic differentiation. The results of this study indicated that a non-thermal plasma offers specific activity with non-destructive properties that can be advantageous for future dental applications.
PB  - Iop Publishing Ltd, Bristol
T2  - Journal of Physics D - Applied Physics
T1  - Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells
VL  - 46
IS  - 34
DO  - 10.1088/0022-3727/46/34/345401
ER  - 

@article{
author = "Miletić, Maja and Mojsilović, S. and Okic-Đorđević, Ivana and Maletić, D. and Puač, Nevena and Lazović, Saša and Malović, Gordana and Milenković, P. and Petrović, Zoran Lj. and Bugarski, Diana",
year = "2013",
abstract = "Here we investigate the influences of non-thermal atmospheric plasma on human mesenchymal stem cells isolated from periodontal ligament (hPDL-MSCs). A specially redesigned plasma needle was used as the source of low-temperature plasma and its effects on different hPDL-MSC functions were investigated. Cell cultures were obtained from extracted normal impacted third molars and characterized for their phenotype and multi-potential differentiation. The hPDL-MSCs possessed all the typical MSC properties, including clonogenic ability, high proliferation rate, specific phenotype and multilineage differentiation. The data regarding the interaction of plasma with hPDL-MSCs demonstrated that plasma treatment inhibited the migration of hPDL-MSCs and induced some detachment, while not affecting their viability. Additionally, plasma significantly attenuated hPDL-MSCs' proliferation, but promoted their osteogenic differentiation. The results of this study indicated that a non-thermal plasma offers specific activity with non-destructive properties that can be advantageous for future dental applications.",
publisher = "Iop Publishing Ltd, Bristol",
journal = "Journal of Physics D - Applied Physics",
title = "Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells",
volume = "46",
number = "34",
doi = "10.1088/0022-3727/46/34/345401"
}

Miletić, M., Mojsilović, S., Okic-Đorđević, I., Maletić, D., Puač, N., Lazović, S., Malović, G., Milenković, P., Petrović, Z. Lj.,& Bugarski, D.. (2013). Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells. in Journal of Physics D - Applied Physics
Iop Publishing Ltd, Bristol., 46(34).
https://doi.org/10.1088/0022-3727/46/34/345401

Miletić M, Mojsilović S, Okic-Đorđević I, Maletić D, Puač N, Lazović S, Malović G, Milenković P, Petrović ZL, Bugarski D. Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells. in Journal of Physics D - Applied Physics. 2013;46(34).
doi:10.1088/0022-3727/46/34/345401 .

Miletić, Maja, Mojsilović, S., Okic-Đorđević, Ivana, Maletić, D., Puač, Nevena, Lazović, Saša, Malović, Gordana, Milenković, P., Petrović, Zoran Lj., Bugarski, Diana, "Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells" in Journal of Physics D - Applied Physics, 46, no. 34 (2013),
https://doi.org/10.1088/0022-3727/46/34/345401 . .

TY  - JOUR
AU  - Miletić, Maja
AU  - Stojanović, R.
AU  - Pajić, O.
AU  - Bugarski, Diana
AU  - Mojsilović, S.
AU  - Cokić, V.
AU  - Milenković, P.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1759
AB  - Background & objectives: The interleukin (IL)-17 producing T-helper cells have been linked to pathogenesis of autoimmunity and mostly investigated in rheumatoid arthritis (RA). In this study we tested the IL-17 levels, as well as the levels of nitric oxide (NO) as possible IL-17-induced product, in patients with primary Sjogren's syndrome (pSS), an intricate and complex chronic autoimmune disorder of exocrine glands. Methods: Serum IL-17 levels and nitrite concentrations determined in patients with pSS (n=30) were compared with the values obtained in patients with RA (n=10) and healthy controls (n=15). The values obtained for 11,17 in pSS patients were also associated with the patients' clinical characteristics, particularly the rheumatoid factor (RF) and total antinuclear antibodies (tANA) levels. Results: Serum concentrations of IL-17 were significantly (P lt 0.01) higher in patients with pSS (12.9 +/- 28.0 pg/ml) as compared to those obtained in healthy individuals (0.2 +/- 0.6 pg/ml), but not as high as the values obtained for the patients with RA (34.5 +/- 56.2 pg/ml). The mean IL-17 levels were significantly (P lt 0.05) higher in the pSS patients positive for rheumatoid factor (20.3 +/- 33.3 pg/ml) than in RF-negatives (0.3 +/- 0.6 pg/ml). Mean serum concentrations of IL-17 were also higher in antinuclear antibody (ANA)positive samples (19.8 +/- 33.5 pg/ml) in comparison to ANA-negative sera (1.1 +/- 3.1 pg/ml) (P lt 0.05). The NO levels also showed elevated values in both pSS and RA patients, as compared to the healthy controls, since mean nitrite levels in patients with pSS and RA were 38.2 +/- 29.2 mu M and 41.7 +/- 21.1 mu M, respectively, while those in healthy controls were significantly lower, at 19.2 +/- 10.5 mu M. Interpretation & conclusions: The findings of this study showed that there was increased IL-17 and NO production in patients with primary SS, especially if they had associated elevated rheumatoid factor and antinuclear antibody values.
PB  - Medknow Publications & Media Pvt Ltd, Mumbai
T2  - Indian Journal of Medical Research
T1  - Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome
VL  - 135
IS  - 4
SP  - 513
EP  - 519
UR  - https://hdl.handle.net/21.15107/rcub_smile_1759
ER  - 

@article{
author = "Miletić, Maja and Stojanović, R. and Pajić, O. and Bugarski, Diana and Mojsilović, S. and Cokić, V. and Milenković, P.",
year = "2012",
abstract = "Background & objectives: The interleukin (IL)-17 producing T-helper cells have been linked to pathogenesis of autoimmunity and mostly investigated in rheumatoid arthritis (RA). In this study we tested the IL-17 levels, as well as the levels of nitric oxide (NO) as possible IL-17-induced product, in patients with primary Sjogren's syndrome (pSS), an intricate and complex chronic autoimmune disorder of exocrine glands. Methods: Serum IL-17 levels and nitrite concentrations determined in patients with pSS (n=30) were compared with the values obtained in patients with RA (n=10) and healthy controls (n=15). The values obtained for 11,17 in pSS patients were also associated with the patients' clinical characteristics, particularly the rheumatoid factor (RF) and total antinuclear antibodies (tANA) levels. Results: Serum concentrations of IL-17 were significantly (P lt 0.01) higher in patients with pSS (12.9 +/- 28.0 pg/ml) as compared to those obtained in healthy individuals (0.2 +/- 0.6 pg/ml), but not as high as the values obtained for the patients with RA (34.5 +/- 56.2 pg/ml). The mean IL-17 levels were significantly (P lt 0.05) higher in the pSS patients positive for rheumatoid factor (20.3 +/- 33.3 pg/ml) than in RF-negatives (0.3 +/- 0.6 pg/ml). Mean serum concentrations of IL-17 were also higher in antinuclear antibody (ANA)positive samples (19.8 +/- 33.5 pg/ml) in comparison to ANA-negative sera (1.1 +/- 3.1 pg/ml) (P lt 0.05). The NO levels also showed elevated values in both pSS and RA patients, as compared to the healthy controls, since mean nitrite levels in patients with pSS and RA were 38.2 +/- 29.2 mu M and 41.7 +/- 21.1 mu M, respectively, while those in healthy controls were significantly lower, at 19.2 +/- 10.5 mu M. Interpretation & conclusions: The findings of this study showed that there was increased IL-17 and NO production in patients with primary SS, especially if they had associated elevated rheumatoid factor and antinuclear antibody values.",
publisher = "Medknow Publications & Media Pvt Ltd, Mumbai",
journal = "Indian Journal of Medical Research",
title = "Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome",
volume = "135",
number = "4",
pages = "513-519",
url = "https://hdl.handle.net/21.15107/rcub_smile_1759"
}

Miletić, M., Stojanović, R., Pajić, O., Bugarski, D., Mojsilović, S., Cokić, V.,& Milenković, P.. (2012). Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome. in Indian Journal of Medical Research
Medknow Publications & Media Pvt Ltd, Mumbai., 135(4), 513-519.
https://hdl.handle.net/21.15107/rcub_smile_1759

Miletić M, Stojanović R, Pajić O, Bugarski D, Mojsilović S, Cokić V, Milenković P. Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome. in Indian Journal of Medical Research. 2012;135(4):513-519.
https://hdl.handle.net/21.15107/rcub_smile_1759 .

Miletić, Maja, Stojanović, R., Pajić, O., Bugarski, Diana, Mojsilović, S., Cokić, V., Milenković, P., "Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome" in Indian Journal of Medical Research, 135, no. 4 (2012):513-519,
https://hdl.handle.net/21.15107/rcub_smile_1759 .

TY  - JOUR
AU  - Petrović, Zoran Lj.
AU  - Puač, Nevena
AU  - Malović, Gordana
AU  - Lazović, Saša
AU  - Maletić, Dejan
AU  - Miletić, Maja
AU  - Mojsilović, Slavko
AU  - Milenković, Pavle
AU  - Bugarski, Diana
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1724
AB  - The potential of plasma applications medicine, the connections to nanotechnologies and the results obtained by our group are reviewed. A special issue in plasma medicine is the development of the plasma sources that would achieve non-equilibrium at atmospheric pressure in an atmospheric gas mixture with no or only marginal heating of the gas, and with desired properties and mechanisms that may be controlled. Our studies have shown that control of radicals or chemically active products of the discharge, such as ROS (reactive oxygen species) and/or NO, may be used to control the growth of the seeds. Simultaneously, a specially designed plasma needle and other sources were shown to be efficient to sterilize not only colonies of bacteria but also plank- tonic samples (microorganisms protected by water) or bio films. Finally, it was shown that a plasma might induce differentiation of stem cells. Non-equilibrium plasmas may be used in detection of different specific markers in medicine. For example proton transfer mass spectroscopy may be employed in the detection of volatile organic compounds without their dissociation and thus as a technique for instantaneous measurement of the presence of markers for numerous diseases.
AB  - U ovom radu dat je pregled primene plazme u medicini, povezanost sa nanotehnologijama i rezultate na ovom polju koje je postigla naša grupa. Poseban problem u plazma medicini je razvoj izvora plazme koji bi radili u neravnotežnim uslovima na atmosferskom pritisku i u smeši gasova kakva je u atmosferi uz zanemarljivo grejanje gasa i sa željenim karakteristikama koje se mogu podešavati po želji. Naša istraživanja su pokazala da se kontrola prisustva radikala i drugih hemijski aktivnih čestica kao što su reaktivne kiseonične čestice (ROS) i/ili NO, može koristiti za kontrolu klijanja semenki. U isto vreme je dokazano za posebno konstruisanu plazma iglu da može efikasno da steriliše ne samo kolonije bakterija već i planktonske uzorke (mikroorganizme zaštićene vodom) pa i biofilmove. Na kraju, mi smo pokazali da plazma može da indukuje diferencijaciju matičnih ćelija. Neravnotežna plazma se može koristiti za detekciju raznih specifičnih markera u medicini. Na primer masena spektroskopija na bazi izmene protona može da se koristi za detekciju isparivih organskih jedinjenja bez njihove disocijacije i na taj način se može ostvariti trenutna detekcija markera za brojne bolesti iz daha.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Application of non-equilibrium plasmas in medicine
T1  - Primena neravnotežne plazme u medicini
VL  - 77
IS  - 12
SP  - 1689
EP  - 1699
DO  - 10.2298/JSC121020142P
ER  - 

@article{
author = "Petrović, Zoran Lj. and Puač, Nevena and Malović, Gordana and Lazović, Saša and Maletić, Dejan and Miletić, Maja and Mojsilović, Slavko and Milenković, Pavle and Bugarski, Diana",
year = "2012",
abstract = "The potential of plasma applications medicine, the connections to nanotechnologies and the results obtained by our group are reviewed. A special issue in plasma medicine is the development of the plasma sources that would achieve non-equilibrium at atmospheric pressure in an atmospheric gas mixture with no or only marginal heating of the gas, and with desired properties and mechanisms that may be controlled. Our studies have shown that control of radicals or chemically active products of the discharge, such as ROS (reactive oxygen species) and/or NO, may be used to control the growth of the seeds. Simultaneously, a specially designed plasma needle and other sources were shown to be efficient to sterilize not only colonies of bacteria but also plank- tonic samples (microorganisms protected by water) or bio films. Finally, it was shown that a plasma might induce differentiation of stem cells. Non-equilibrium plasmas may be used in detection of different specific markers in medicine. For example proton transfer mass spectroscopy may be employed in the detection of volatile organic compounds without their dissociation and thus as a technique for instantaneous measurement of the presence of markers for numerous diseases., U ovom radu dat je pregled primene plazme u medicini, povezanost sa nanotehnologijama i rezultate na ovom polju koje je postigla naša grupa. Poseban problem u plazma medicini je razvoj izvora plazme koji bi radili u neravnotežnim uslovima na atmosferskom pritisku i u smeši gasova kakva je u atmosferi uz zanemarljivo grejanje gasa i sa željenim karakteristikama koje se mogu podešavati po želji. Naša istraživanja su pokazala da se kontrola prisustva radikala i drugih hemijski aktivnih čestica kao što su reaktivne kiseonične čestice (ROS) i/ili NO, može koristiti za kontrolu klijanja semenki. U isto vreme je dokazano za posebno konstruisanu plazma iglu da može efikasno da steriliše ne samo kolonije bakterija već i planktonske uzorke (mikroorganizme zaštićene vodom) pa i biofilmove. Na kraju, mi smo pokazali da plazma može da indukuje diferencijaciju matičnih ćelija. Neravnotežna plazma se može koristiti za detekciju raznih specifičnih markera u medicini. Na primer masena spektroskopija na bazi izmene protona može da se koristi za detekciju isparivih organskih jedinjenja bez njihove disocijacije i na taj način se može ostvariti trenutna detekcija markera za brojne bolesti iz daha.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Application of non-equilibrium plasmas in medicine, Primena neravnotežne plazme u medicini",
volume = "77",
number = "12",
pages = "1689-1699",
doi = "10.2298/JSC121020142P"
}

Petrović, Z. Lj., Puač, N., Malović, G., Lazović, S., Maletić, D., Miletić, M., Mojsilović, S., Milenković, P.,& Bugarski, D.. (2012). Application of non-equilibrium plasmas in medicine. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 77(12), 1689-1699.
https://doi.org/10.2298/JSC121020142P

Petrović ZL, Puač N, Malović G, Lazović S, Maletić D, Miletić M, Mojsilović S, Milenković P, Bugarski D. Application of non-equilibrium plasmas in medicine. in Journal of the Serbian Chemical Society. 2012;77(12):1689-1699.
doi:10.2298/JSC121020142P .

Petrović, Zoran Lj., Puač, Nevena, Malović, Gordana, Lazović, Saša, Maletić, Dejan, Miletić, Maja, Mojsilović, Slavko, Milenković, Pavle, Bugarski, Diana, "Application of non-equilibrium plasmas in medicine" in Journal of the Serbian Chemical Society, 77, no. 12 (2012):1689-1699,
https://doi.org/10.2298/JSC121020142P . .

TY  - JOUR
AU  - Lazović, Saša
AU  - Puač, Nevena
AU  - Miletić, Maja
AU  - Pavlica, Dušan
AU  - Jovanović, Milena
AU  - Bugarski, Diana
AU  - Mojsilović, Slavko
AU  - Maletić, Dejan
AU  - Malović, Gordana
AU  - Milenković, Pavle
AU  - Petrović, Zoran Lj.
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1559
AB  - In this paper, we study the application of a plasma needle to induce necrosis in planktonic samples containing a single breed of bacteria. Two different types of bacteria, Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922), were covered in this study. In all experiments with bacteria, the samples were liquid suspensions of several different concentrations of bacteria prepared according to the McFarland standard. The second system studied in this paper was human peripheral blood mesenchymal stem cells (hPB-MSC). In the case of hPB-MSC, two sets of experiments were performed: when cells were covered with a certain amount of liquid (indirect) and when the cell sample was in direct contact with the plasma. Most importantly, the study is made with the aim to see the effects when the living cells are in a liquid medium, which normally acts as protection against the many agents that may be released by plasmas. It was found that a good effect may be expected for a wide range of initial cell densities and operating conditions causing destruction of several orders of magnitude even under the protection of a liquid. It was established independently that a temperature increase could not affect the cells under the conditions of our experiment, so the effect could those hPB-MSC that were not protected by a liquid, gas flow proved to produce a considerable effect, presumably due to poor adhesion of the cells, but in a liquid the effect was only due to the plasma. Further optimization of the operation may be attempted, opening up the possibility of localized in vivo sterilization.
PB  - Iop Publishing Ltd, Bristol
T2  - New Journal of Physics
T1  - The effect of a plasma needle on bacteria in planktonic samples and on peripheral blood mesenchymal stem cells
VL  - 12
DO  - 10.1088/1367-2630/12/8/083037
ER  - 

@article{
author = "Lazović, Saša and Puač, Nevena and Miletić, Maja and Pavlica, Dušan and Jovanović, Milena and Bugarski, Diana and Mojsilović, Slavko and Maletić, Dejan and Malović, Gordana and Milenković, Pavle and Petrović, Zoran Lj.",
year = "2010",
abstract = "In this paper, we study the application of a plasma needle to induce necrosis in planktonic samples containing a single breed of bacteria. Two different types of bacteria, Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922), were covered in this study. In all experiments with bacteria, the samples were liquid suspensions of several different concentrations of bacteria prepared according to the McFarland standard. The second system studied in this paper was human peripheral blood mesenchymal stem cells (hPB-MSC). In the case of hPB-MSC, two sets of experiments were performed: when cells were covered with a certain amount of liquid (indirect) and when the cell sample was in direct contact with the plasma. Most importantly, the study is made with the aim to see the effects when the living cells are in a liquid medium, which normally acts as protection against the many agents that may be released by plasmas. It was found that a good effect may be expected for a wide range of initial cell densities and operating conditions causing destruction of several orders of magnitude even under the protection of a liquid. It was established independently that a temperature increase could not affect the cells under the conditions of our experiment, so the effect could those hPB-MSC that were not protected by a liquid, gas flow proved to produce a considerable effect, presumably due to poor adhesion of the cells, but in a liquid the effect was only due to the plasma. Further optimization of the operation may be attempted, opening up the possibility of localized in vivo sterilization.",
publisher = "Iop Publishing Ltd, Bristol",
journal = "New Journal of Physics",
title = "The effect of a plasma needle on bacteria in planktonic samples and on peripheral blood mesenchymal stem cells",
volume = "12",
doi = "10.1088/1367-2630/12/8/083037"
}

Lazović, S., Puač, N., Miletić, M., Pavlica, D., Jovanović, M., Bugarski, D., Mojsilović, S., Maletić, D., Malović, G., Milenković, P.,& Petrović, Z. Lj.. (2010). The effect of a plasma needle on bacteria in planktonic samples and on peripheral blood mesenchymal stem cells. in New Journal of Physics
Iop Publishing Ltd, Bristol., 12.
https://doi.org/10.1088/1367-2630/12/8/083037

Lazović S, Puač N, Miletić M, Pavlica D, Jovanović M, Bugarski D, Mojsilović S, Maletić D, Malović G, Milenković P, Petrović ZL. The effect of a plasma needle on bacteria in planktonic samples and on peripheral blood mesenchymal stem cells. in New Journal of Physics. 2010;12.
doi:10.1088/1367-2630/12/8/083037 .

Lazović, Saša, Puač, Nevena, Miletić, Maja, Pavlica, Dušan, Jovanović, Milena, Bugarski, Diana, Mojsilović, Slavko, Maletić, Dejan, Malović, Gordana, Milenković, Pavle, Petrović, Zoran Lj., "The effect of a plasma needle on bacteria in planktonic samples and on peripheral blood mesenchymal stem cells" in New Journal of Physics, 12 (2010),
https://doi.org/10.1088/1367-2630/12/8/083037 . .

TY  - CONF
AU  - Dokmanović-Miletić, Maja
AU  - Stojanović, R. M.
AU  - Pajić, O.
AU  - Bugarski, Diana
AU  - Marković, D.
AU  - Milenković, P. B.
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1315
PB  - B M J Publishing Group, London
C3  - Annals of the Rheumatic Diseases
T1  - Incidence of anti-alfa fodrin antibodies in primary sjogren syndrome and its correlation with anti ro/SS-A and anti La/SS-B antibodies
VL  - 65
SP  - 299
EP  - 299
UR  - https://hdl.handle.net/21.15107/rcub_smile_1315
ER  - 

@conference{
author = "Dokmanović-Miletić, Maja and Stojanović, R. M. and Pajić, O. and Bugarski, Diana and Marković, D. and Milenković, P. B.",
year = "2006",
publisher = "B M J Publishing Group, London",
journal = "Annals of the Rheumatic Diseases",
title = "Incidence of anti-alfa fodrin antibodies in primary sjogren syndrome and its correlation with anti ro/SS-A and anti La/SS-B antibodies",
volume = "65",
pages = "299-299",
url = "https://hdl.handle.net/21.15107/rcub_smile_1315"
}

Dokmanović-Miletić, M., Stojanović, R. M., Pajić, O., Bugarski, D., Marković, D.,& Milenković, P. B.. (2006). Incidence of anti-alfa fodrin antibodies in primary sjogren syndrome and its correlation with anti ro/SS-A and anti La/SS-B antibodies. in Annals of the Rheumatic Diseases
B M J Publishing Group, London., 65, 299-299.
https://hdl.handle.net/21.15107/rcub_smile_1315

Dokmanović-Miletić M, Stojanović RM, Pajić O, Bugarski D, Marković D, Milenković PB. Incidence of anti-alfa fodrin antibodies in primary sjogren syndrome and its correlation with anti ro/SS-A and anti La/SS-B antibodies. in Annals of the Rheumatic Diseases. 2006;65:299-299.
https://hdl.handle.net/21.15107/rcub_smile_1315 .

Dokmanović-Miletić, Maja, Stojanović, R. M., Pajić, O., Bugarski, Diana, Marković, D., Milenković, P. B., "Incidence of anti-alfa fodrin antibodies in primary sjogren syndrome and its correlation with anti ro/SS-A and anti La/SS-B antibodies" in Annals of the Rheumatic Diseases, 65 (2006):299-299,
https://hdl.handle.net/21.15107/rcub_smile_1315 .

TY  - THES
AU  - Dokmanović-Miletić, Maja
PY  - 2005
UR  - https://plus.sr.cobiss.net/opac7/bib/1024083086
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/409
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Značaj ispitivanja anti-alfa fodrinskih antitela i IL-17 u serumu bolesnika sa primarnim Sjögrenovim sindromom
UR  - https://hdl.handle.net/21.15107/rcub_smile_409
ER  - 

@mastersthesis{
author = "Dokmanović-Miletić, Maja",
year = "2005",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Značaj ispitivanja anti-alfa fodrinskih antitela i IL-17 u serumu bolesnika sa primarnim Sjögrenovim sindromom",
url = "https://hdl.handle.net/21.15107/rcub_smile_409"
}

Dokmanović-Miletić, M.. (2005). Značaj ispitivanja anti-alfa fodrinskih antitela i IL-17 u serumu bolesnika sa primarnim Sjögrenovim sindromom. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_409

Dokmanović-Miletić M. Značaj ispitivanja anti-alfa fodrinskih antitela i IL-17 u serumu bolesnika sa primarnim Sjögrenovim sindromom. 2005;.
https://hdl.handle.net/21.15107/rcub_smile_409 .

Dokmanović-Miletić, Maja, "Značaj ispitivanja anti-alfa fodrinskih antitela i IL-17 u serumu bolesnika sa primarnim Sjögrenovim sindromom" (2005),
https://hdl.handle.net/21.15107/rcub_smile_409 .