TY  - JOUR
AU  - Lazarević, Miloš
AU  - Milošević, Maja
AU  - Petrović, Nada
AU  - Petrović, Slobodan
AU  - Damante, Giuseppe
AU  - Milašin, Jelena
AU  - Milovanović, Branislav
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2403
AB  - Background/Aim: Current approaches in therapy of head and neck cancers are surgery, radiotherapy and chemotherapy. However, recurrence, development of multidrug resistance, side effects, and high costs of therapy are significant problems which point to the need for more efficient and less toxic drugs and interventions. Material and Methods: Eight essential oils obtained from Thymus serpyllum, Mentha piperita, Juniperus communis, Rosmarinus officinalis, Melissa officinalis, Achillea millefolium, Zingiber officinale, and Helichrysum arenarium were tested for their anti-proliferative on oral squamous cell carcinoma (OSCC) culture and SCC-25 cell line. Cytotoxicity assays (MTT and Neutral red) were used to detect the effect of the mentioned essential oils. Results: T. serpyllum, M. piperita, J. communis, and R. officinalis essential oils exhibited the best anti-proliferative effect, on both types of cells. M. piperita had the greatest effect on SCC-25 cell line (4,5% of viable cells) and OSCC cells (7,2% of viable cells). Overall, cytotoxicity was higher in OSCC than in SCC-25 cell line. Conclusions: This study showed a clear anti-proliferative effect of four essential oils, in vitro making them novel potential antineoplastic agents.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Dental Medicine
T1  - Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study
VL  - 23
IS  - 2
SP  - 73
EP  - 79
DO  - 10.2478/bjdm-2019-0014
ER  - 

@article{
author = "Lazarević, Miloš and Milošević, Maja and Petrović, Nada and Petrović, Slobodan and Damante, Giuseppe and Milašin, Jelena and Milovanović, Branislav",
year = "2019",
abstract = "Background/Aim: Current approaches in therapy of head and neck cancers are surgery, radiotherapy and chemotherapy. However, recurrence, development of multidrug resistance, side effects, and high costs of therapy are significant problems which point to the need for more efficient and less toxic drugs and interventions. Material and Methods: Eight essential oils obtained from Thymus serpyllum, Mentha piperita, Juniperus communis, Rosmarinus officinalis, Melissa officinalis, Achillea millefolium, Zingiber officinale, and Helichrysum arenarium were tested for their anti-proliferative on oral squamous cell carcinoma (OSCC) culture and SCC-25 cell line. Cytotoxicity assays (MTT and Neutral red) were used to detect the effect of the mentioned essential oils. Results: T. serpyllum, M. piperita, J. communis, and R. officinalis essential oils exhibited the best anti-proliferative effect, on both types of cells. M. piperita had the greatest effect on SCC-25 cell line (4,5% of viable cells) and OSCC cells (7,2% of viable cells). Overall, cytotoxicity was higher in OSCC than in SCC-25 cell line. Conclusions: This study showed a clear anti-proliferative effect of four essential oils, in vitro making them novel potential antineoplastic agents.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Dental Medicine",
title = "Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study",
volume = "23",
number = "2",
pages = "73-79",
doi = "10.2478/bjdm-2019-0014"
}

Lazarević, M., Milošević, M., Petrović, N., Petrović, S., Damante, G., Milašin, J.,& Milovanović, B.. (2019). Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study. in Balkan Journal of Dental Medicine
Udruženje stomatologa Balkana., 23(2), 73-79.
https://doi.org/10.2478/bjdm-2019-0014

Lazarević M, Milošević M, Petrović N, Petrović S, Damante G, Milašin J, Milovanović B. Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study. in Balkan Journal of Dental Medicine. 2019;23(2):73-79.
doi:10.2478/bjdm-2019-0014 .

Lazarević, Miloš, Milošević, Maja, Petrović, Nada, Petrović, Slobodan, Damante, Giuseppe, Milašin, Jelena, Milovanović, Branislav, "Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study" in Balkan Journal of Dental Medicine, 23, no. 2 (2019):73-79,
https://doi.org/10.2478/bjdm-2019-0014 . .

TY  - JOUR
AU  - Pavlović, Sanja
AU  - Stević, Zorica
AU  - Milovanović, Branislav
AU  - Miličić, Biljana
AU  - Rakocević-Stojanović, Vidosava
AU  - Lavrnić, Dragana
AU  - Apostolski, Slobodan
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1598
AB  - The aim of this study was to investigate autonomic cardiac control in patients with amyotrophic lateral sclerosis (ALS). Fifty-five patients with sporadic ALS (28 female and 27 male; average age 56.00 +/- 10.34 years) were compared to 30 healthy controls (17 female and 13 male; average age 42.87 +/- 11.91 years). Patients with previous history of cardiac disease, diabetes mellitus, and impaired respiratory function were excluded from the study. Cardiovascular autonomic tests according to Ewing, power spectrum analysis of RR variability (low- and high-frequency bands - LF and HF, LF/HF index), real-time beat-to-beat ECG signal monitoring with heart rate variability analysis and baroreflex function analysis were carried out in all patients. Time-domain parameters of heart rate variability (mean RR interval, SDNN, SDANN, SDNN index, rMSSD and pNN50%) were obtained from 24-h ECG monitoring. ALS patients had a significantly higher score of sympathetic (p  lt  0.01) and parasympathetic (p  lt  0.001) dysfunction, as well as of the overall score of autonomic dysfunction (p  lt  0.001). LF/HF index was significantly increased; baroreflex sensitivity and time-domain parameters of heart rate variability were highly significantly decreased in ALS patients (p  lt  0.001). Our results demonstrated impaired cardiac autonomic control in ALS with marked parasympathetic dysfunction and sympathetic predominance.
PB  - Informa Healthcare, London
T2  - Amyotrophic Lateral Sclerosis
T1  - Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis
VL  - 11
IS  - 3
SP  - 272
EP  - 276
DO  - 10.3109/17482960903390855
ER  - 

@article{
author = "Pavlović, Sanja and Stević, Zorica and Milovanović, Branislav and Miličić, Biljana and Rakocević-Stojanović, Vidosava and Lavrnić, Dragana and Apostolski, Slobodan",
year = "2010",
abstract = "The aim of this study was to investigate autonomic cardiac control in patients with amyotrophic lateral sclerosis (ALS). Fifty-five patients with sporadic ALS (28 female and 27 male; average age 56.00 +/- 10.34 years) were compared to 30 healthy controls (17 female and 13 male; average age 42.87 +/- 11.91 years). Patients with previous history of cardiac disease, diabetes mellitus, and impaired respiratory function were excluded from the study. Cardiovascular autonomic tests according to Ewing, power spectrum analysis of RR variability (low- and high-frequency bands - LF and HF, LF/HF index), real-time beat-to-beat ECG signal monitoring with heart rate variability analysis and baroreflex function analysis were carried out in all patients. Time-domain parameters of heart rate variability (mean RR interval, SDNN, SDANN, SDNN index, rMSSD and pNN50%) were obtained from 24-h ECG monitoring. ALS patients had a significantly higher score of sympathetic (p  lt  0.01) and parasympathetic (p  lt  0.001) dysfunction, as well as of the overall score of autonomic dysfunction (p  lt  0.001). LF/HF index was significantly increased; baroreflex sensitivity and time-domain parameters of heart rate variability were highly significantly decreased in ALS patients (p  lt  0.001). Our results demonstrated impaired cardiac autonomic control in ALS with marked parasympathetic dysfunction and sympathetic predominance.",
publisher = "Informa Healthcare, London",
journal = "Amyotrophic Lateral Sclerosis",
title = "Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis",
volume = "11",
number = "3",
pages = "272-276",
doi = "10.3109/17482960903390855"
}

Pavlović, S., Stević, Z., Milovanović, B., Miličić, B., Rakocević-Stojanović, V., Lavrnić, D.,& Apostolski, S.. (2010). Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis. in Amyotrophic Lateral Sclerosis
Informa Healthcare, London., 11(3), 272-276.
https://doi.org/10.3109/17482960903390855

Pavlović S, Stević Z, Milovanović B, Miličić B, Rakocević-Stojanović V, Lavrnić D, Apostolski S. Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis. in Amyotrophic Lateral Sclerosis. 2010;11(3):272-276.
doi:10.3109/17482960903390855 .

Pavlović, Sanja, Stević, Zorica, Milovanović, Branislav, Miličić, Biljana, Rakocević-Stojanović, Vidosava, Lavrnić, Dragana, Apostolski, Slobodan, "Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis" in Amyotrophic Lateral Sclerosis, 11, no. 3 (2010):272-276,
https://doi.org/10.3109/17482960903390855 . .