TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Milašin, Jelena
AU  - Sabeti, Mohammad
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2595
AB  - Purpose of Review
This review describes the most recent findings on herpesviral infections and offers current concepts of herpesviral role in the pathogenesis of periapical periodontitis.

Recent Findings
Thirty articles reported data on herpesviral infection in periapical periodontitis. Epstein-Barr virus and human cytomegalovirus are the most frequently detected herpesviruses in periapical samples. The main hypothesis postulates a bidirectional herpesviral-bacterial relationship in the etiopathogenesis of periapical periodontitis. A high heterogeneity of herpesviruses incidence was registered within the studies, in part, due to various methodological approaches used in laboratory testing, different inclusion criteria, study design, seroprevalence of herpesviruses, and sociodemographic characteristics of investigated populations.

Summary
Herpesviruses have been shown to potentially impair local host defense in periapical tissue. Although it has been demonstrated that endodontic pathogenic bacteria are able to reactivate herpesviruses, further, in vitro studies should provide more data on herpesviruses as a factor in the pathogenesis of the periapical pathoses. It is, therefore, necessary to investigate potential benefits of antiviral therapy in well-designed controlled longitudinal studies.
PB  - Springer
T2  - Current Oral Health Reports
T1  - Herpesviral Infection in Periapical Periodontitis
VL  - 5
IS  - 4
SP  - 255
EP  - 263
DO  - 10.1007/s40496-018-0198-7
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Miletić, Maja and Beljić-Ivanović, Katarina and Milašin, Jelena and Sabeti, Mohammad",
year = "2018",
abstract = "Purpose of Review
This review describes the most recent findings on herpesviral infections and offers current concepts of herpesviral role in the pathogenesis of periapical periodontitis.

Recent Findings
Thirty articles reported data on herpesviral infection in periapical periodontitis. Epstein-Barr virus and human cytomegalovirus are the most frequently detected herpesviruses in periapical samples. The main hypothesis postulates a bidirectional herpesviral-bacterial relationship in the etiopathogenesis of periapical periodontitis. A high heterogeneity of herpesviruses incidence was registered within the studies, in part, due to various methodological approaches used in laboratory testing, different inclusion criteria, study design, seroprevalence of herpesviruses, and sociodemographic characteristics of investigated populations.

Summary
Herpesviruses have been shown to potentially impair local host defense in periapical tissue. Although it has been demonstrated that endodontic pathogenic bacteria are able to reactivate herpesviruses, further, in vitro studies should provide more data on herpesviruses as a factor in the pathogenesis of the periapical pathoses. It is, therefore, necessary to investigate potential benefits of antiviral therapy in well-designed controlled longitudinal studies.",
publisher = "Springer",
journal = "Current Oral Health Reports",
title = "Herpesviral Infection in Periapical Periodontitis",
volume = "5",
number = "4",
pages = "255-263",
doi = "10.1007/s40496-018-0198-7"
}

Jakovljević, A., Andrić, M., Knežević, A., Miletić, M., Beljić-Ivanović, K., Milašin, J.,& Sabeti, M.. (2018). Herpesviral Infection in Periapical Periodontitis. in Current Oral Health Reports
Springer., 5(4), 255-263.
https://doi.org/10.1007/s40496-018-0198-7

Jakovljević A, Andrić M, Knežević A, Miletić M, Beljić-Ivanović K, Milašin J, Sabeti M. Herpesviral Infection in Periapical Periodontitis. in Current Oral Health Reports. 2018;5(4):255-263.
doi:10.1007/s40496-018-0198-7 .

Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Miletić, Maja, Beljić-Ivanović, Katarina, Milašin, Jelena, Sabeti, Mohammad, "Herpesviral Infection in Periapical Periodontitis" in Current Oral Health Reports, 5, no. 4 (2018):255-263,
https://doi.org/10.1007/s40496-018-0198-7 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Knežević, Aleksandra
AU  - Nikolić, Nadja
AU  - Soldatović, Ivan
AU  - Jovanović, T.
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2296
AB  - ObjectivesThis study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-, IL-1 and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels of proinflammatory cytokines. Materials and MethodsA total of 100 samples of apical periodontitis were subjected to HCMV and EBV copy numbers analysis by nested polymerase chain reaction (PCR) and TaqMan real-time PCR. The concentrations of TNF-, IL-1 and IL-6 were determined by ELISA method. SPSS software was used for statistical analysis. ResultsThere were no significant differences in the occurrence of EBV and HCMV between symptomatic and asymptomatic periapical lesions (p=.686, p=.879, respectively). Only 12 of 74 EBV (16.2%) and four of 54 HCMV (13.5%) nested PCR-positive samples showed increased viral copy numbers above the limit of 125 copies/ml. There was no significant correlation between the levels of analysed proinflammatory cytokines and herpesviral copy numbers in our sample. ConclusionThe observed low viral loads point to a relatively rare occurrence of active EBV and HCMV infection in our sample. Latent herpesviral infection does not enhance the production of investigated proinflammatory cytokines.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis
VL  - 24
IS  - 5
SP  - 840
EP  - 846
DO  - 10.1111/odi.12829
ER  - 

@article{
author = "Jakovljević, Aleksandar and Knežević, Aleksandra and Nikolić, Nadja and Soldatović, Ivan and Jovanović, T. and Milašin, Jelena and Andrić, Miroslav",
year = "2018",
abstract = "ObjectivesThis study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-, IL-1 and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels of proinflammatory cytokines. Materials and MethodsA total of 100 samples of apical periodontitis were subjected to HCMV and EBV copy numbers analysis by nested polymerase chain reaction (PCR) and TaqMan real-time PCR. The concentrations of TNF-, IL-1 and IL-6 were determined by ELISA method. SPSS software was used for statistical analysis. ResultsThere were no significant differences in the occurrence of EBV and HCMV between symptomatic and asymptomatic periapical lesions (p=.686, p=.879, respectively). Only 12 of 74 EBV (16.2%) and four of 54 HCMV (13.5%) nested PCR-positive samples showed increased viral copy numbers above the limit of 125 copies/ml. There was no significant correlation between the levels of analysed proinflammatory cytokines and herpesviral copy numbers in our sample. ConclusionThe observed low viral loads point to a relatively rare occurrence of active EBV and HCMV infection in our sample. Latent herpesviral infection does not enhance the production of investigated proinflammatory cytokines.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis",
volume = "24",
number = "5",
pages = "840-846",
doi = "10.1111/odi.12829"
}

Jakovljević, A., Knežević, A., Nikolić, N., Soldatović, I., Jovanović, T., Milašin, J.,& Andrić, M.. (2018). Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis. in Oral Diseases
Wiley, Hoboken., 24(5), 840-846.
https://doi.org/10.1111/odi.12829

Jakovljević A, Knežević A, Nikolić N, Soldatović I, Jovanović T, Milašin J, Andrić M. Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis. in Oral Diseases. 2018;24(5):840-846.
doi:10.1111/odi.12829 .

Jakovljević, Aleksandar, Knežević, Aleksandra, Nikolić, Nadja, Soldatović, Ivan, Jovanović, T., Milašin, Jelena, Andrić, Miroslav, "Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis" in Oral Diseases, 24, no. 5 (2018):840-846,
https://doi.org/10.1111/odi.12829 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Nikolić, Nadja
AU  - Corić, V.
AU  - Krezović, S.
AU  - Čarkić, Jelena
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Pljesa-Ercegovac, M.
AU  - Miletić, Maja
AU  - Soldatović, Ivan
AU  - Radosavljević, T.
AU  - Jovanović, T.
AU  - Simić, T.
AU  - Ivanović, Vladimir
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2293
AB  - AimTo investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] and bone resorption regulators [receptor activator of nuclear factor (NF-B) ligand (RANKL) and osteoprotegerin (OPG)] compared to EBV-negative periapical lesions and healthy pulp tissues. MethodologyThe experimental group consisted of 30 EBV-positive and 30 EBV-negative periapical lesions collected in conjunction with apicoectomy. The pulp tissues of 20 impacted third molars were used as healthy controls. The qualitative and quantitative analysis of EBV was performed by nested and real-time polymerase chain reaction (PCR), respectively. The levels of RANKL and OPG were analysed by reverse transcriptase real-time PCR. The levels of 8-OHdG and GSSG were determined by enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U-test and Spearman's correlation were used for statistical analysis. ResultsThe levels of RANKL, OPG, 8-OHdG and GSSG were significantly higher in apical periodontitis lesions compared to healthy pulp controls (P=0.001, P lt 0.001, P lt 0.001 and P lt 0.05, respectively). RANKL and OPG mRNA expression was significantly higher in EBV-positive compared to EBV-negative periapical lesions (P lt 0.05). There was no significant correlation between EBV copy numbers and levels of RANKL, OPG, 8OH-dG and GSSG in apical periodontitis. ConclusionLevels of bone resorption regulators and oxidative stress biomarkers were increased in apical periodontitis compared to healthy pulp tissues. EBV-positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV-negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.
PB  - Wiley, Hoboken
T2  - International Endodontic Journal
T1  - Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus
VL  - 51
IS  - 6
SP  - 593
EP  - 604
DO  - 10.1111/iej.12886
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Nikolić, Nadja and Corić, V. and Krezović, S. and Čarkić, Jelena and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Pljesa-Ercegovac, M. and Miletić, Maja and Soldatović, Ivan and Radosavljević, T. and Jovanović, T. and Simić, T. and Ivanović, Vladimir and Milašin, Jelena",
year = "2018",
abstract = "AimTo investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] and bone resorption regulators [receptor activator of nuclear factor (NF-B) ligand (RANKL) and osteoprotegerin (OPG)] compared to EBV-negative periapical lesions and healthy pulp tissues. MethodologyThe experimental group consisted of 30 EBV-positive and 30 EBV-negative periapical lesions collected in conjunction with apicoectomy. The pulp tissues of 20 impacted third molars were used as healthy controls. The qualitative and quantitative analysis of EBV was performed by nested and real-time polymerase chain reaction (PCR), respectively. The levels of RANKL and OPG were analysed by reverse transcriptase real-time PCR. The levels of 8-OHdG and GSSG were determined by enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U-test and Spearman's correlation were used for statistical analysis. ResultsThe levels of RANKL, OPG, 8-OHdG and GSSG were significantly higher in apical periodontitis lesions compared to healthy pulp controls (P=0.001, P lt 0.001, P lt 0.001 and P lt 0.05, respectively). RANKL and OPG mRNA expression was significantly higher in EBV-positive compared to EBV-negative periapical lesions (P lt 0.05). There was no significant correlation between EBV copy numbers and levels of RANKL, OPG, 8OH-dG and GSSG in apical periodontitis. ConclusionLevels of bone resorption regulators and oxidative stress biomarkers were increased in apical periodontitis compared to healthy pulp tissues. EBV-positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV-negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.",
publisher = "Wiley, Hoboken",
journal = "International Endodontic Journal",
title = "Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus",
volume = "51",
number = "6",
pages = "593-604",
doi = "10.1111/iej.12886"
}

Jakovljević, A., Andrić, M., Nikolić, N., Corić, V., Krezović, S., Čarkić, J., Knežević, A., Beljić-Ivanović, K., Pljesa-Ercegovac, M., Miletić, M., Soldatović, I., Radosavljević, T., Jovanović, T., Simić, T., Ivanović, V.,& Milašin, J.. (2018). Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. in International Endodontic Journal
Wiley, Hoboken., 51(6), 593-604.
https://doi.org/10.1111/iej.12886

Jakovljević A, Andrić M, Nikolić N, Corić V, Krezović S, Čarkić J, Knežević A, Beljić-Ivanović K, Pljesa-Ercegovac M, Miletić M, Soldatović I, Radosavljević T, Jovanović T, Simić T, Ivanović V, Milašin J. Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. in International Endodontic Journal. 2018;51(6):593-604.
doi:10.1111/iej.12886 .

Jakovljević, Aleksandar, Andrić, Miroslav, Nikolić, Nadja, Corić, V., Krezović, S., Čarkić, Jelena, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Pljesa-Ercegovac, M., Miletić, Maja, Soldatović, Ivan, Radosavljević, T., Jovanović, T., Simić, T., Ivanović, Vladimir, Milašin, Jelena, "Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus" in International Endodontic Journal, 51, no. 6 (2018):593-604,
https://doi.org/10.1111/iej.12886 . .

TY  - THES
AU  - Knežević, Aleksandra
PY  - 2017
UR  - https://plus.sr.cobiss.net/opac7/bib/1024324238
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/781
AB  - Mentalna oboljenja predstavljaju problematiku savremenog društva u porastu. Shizofrenija i depresija kao jedni od predstavnika mnogobrojnih mentalnih poremećaja mogu izazvati indirektno dodatna oralna oboljenja. Na zdravlje usta i zuba mentalni poremećaji utiču dvojako. Usled osnovne bolesti dolazi do izmena ponašanja. Smanjenjem volje i brige za opšte oralno zdravlje dovodi do loših zdravstvenih navika pacijenata, a posebno izraženo kod hospitalizovanih bolesnika. Osebe sa mentalnim poremećajima jesu grupa pacijenata rizika za oboljenja usta i zuba, nastalih kao posledica osnovne bolesti ili uticaja lekova koji se primenjuju u terapiji. Oralno zdravlje je rezultat opšte zdravstvenog stanja, štetnih navika i načina u ishrani. Istraživanja su pokazala da ova populacija, u odnosu na opštu, ima više izvađenih, karijesom zahvaćenih i manje plombiranih zuba. Kod ovih bolesnika utvrđene su česta pojava suvoće u ustima, naslage na jeziku, žarenje i peckanje, poremećaj čula ukusa. Antipsihotična terapija koja se primenjuje u lečenju takođe nepovoljno utiče na oralno zdravlje. Ovi pacijenti su uglavnom na dugotrajnoj terapiji a samim tim se povećava stepen oštećenja oralnog zdravlja. Akcenat u lečenju oralnih oboljenja odnosi se na profilaksu kao meru kojom se utiče na pobuđivanje svesti i preuzimanje odgovornosti pojedinca za sopstveno zdravlje. Osobe sa mentalnim poremećajima nemaju zadovoljavajući odnos u odnosu na oralno zdravlje. Razlog tome leži u strahu od intervencije, nedovoljnim materijalnim sredstvima, nepostojanju osiguranja za stomatološke usluge, ali i nedovoljnom broju stomatologa i lekara opšte prakse koji treba da pruže znanje i veštine pacijentima.
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Prevencija oralnih oboljenja kod psihijatrijskih pacijenata
UR  - https://hdl.handle.net/21.15107/rcub_smile_781
ER  - 

@misc{
author = "Knežević, Aleksandra",
year = "2017",
abstract = "Mentalna oboljenja predstavljaju problematiku savremenog društva u porastu. Shizofrenija i depresija kao jedni od predstavnika mnogobrojnih mentalnih poremećaja mogu izazvati indirektno dodatna oralna oboljenja. Na zdravlje usta i zuba mentalni poremećaji utiču dvojako. Usled osnovne bolesti dolazi do izmena ponašanja. Smanjenjem volje i brige za opšte oralno zdravlje dovodi do loših zdravstvenih navika pacijenata, a posebno izraženo kod hospitalizovanih bolesnika. Osebe sa mentalnim poremećajima jesu grupa pacijenata rizika za oboljenja usta i zuba, nastalih kao posledica osnovne bolesti ili uticaja lekova koji se primenjuju u terapiji. Oralno zdravlje je rezultat opšte zdravstvenog stanja, štetnih navika i načina u ishrani. Istraživanja su pokazala da ova populacija, u odnosu na opštu, ima više izvađenih, karijesom zahvaćenih i manje plombiranih zuba. Kod ovih bolesnika utvrđene su česta pojava suvoće u ustima, naslage na jeziku, žarenje i peckanje, poremećaj čula ukusa. Antipsihotična terapija koja se primenjuje u lečenju takođe nepovoljno utiče na oralno zdravlje. Ovi pacijenti su uglavnom na dugotrajnoj terapiji a samim tim se povećava stepen oštećenja oralnog zdravlja. Akcenat u lečenju oralnih oboljenja odnosi se na profilaksu kao meru kojom se utiče na pobuđivanje svesti i preuzimanje odgovornosti pojedinca za sopstveno zdravlje. Osobe sa mentalnim poremećajima nemaju zadovoljavajući odnos u odnosu na oralno zdravlje. Razlog tome leži u strahu od intervencije, nedovoljnim materijalnim sredstvima, nepostojanju osiguranja za stomatološke usluge, ali i nedovoljnom broju stomatologa i lekara opšte prakse koji treba da pruže znanje i veštine pacijentima.",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Prevencija oralnih oboljenja kod psihijatrijskih pacijenata",
url = "https://hdl.handle.net/21.15107/rcub_smile_781"
}

Knežević, A.. (2017). Prevencija oralnih oboljenja kod psihijatrijskih pacijenata. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_781

Knežević A. Prevencija oralnih oboljenja kod psihijatrijskih pacijenata. 2017;.
https://hdl.handle.net/21.15107/rcub_smile_781 .

Knežević, Aleksandra, "Prevencija oralnih oboljenja kod psihijatrijskih pacijenata" (2017),
https://hdl.handle.net/21.15107/rcub_smile_781 .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Kuzmanović, Jovana
AU  - Dragan, Irina E.
AU  - Knežević, Aleksandra
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2223
AB  - Introduction: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies. Methods: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus. A qualitative critical appraisal of the included articles was performed. Results: The electronic database search. yielded 66 hits from PubMed, 73 hits from Web of Science, and 107 from Scopus: Seven case reports and 3 cross-sectional studies were included in the final review. When summarized, in 7 patients with a history of a previous HZ attack and with no other apparent cause, -23 teeth were diagnosed with apical periodontitis, 8 teeth with internal and 1 tooth with external root resorption. The cross-sectional studies investigated the presence of VZV DNA in samples of acute apical abscess. The VZV DNA was found only in 2 of 65 samples. Conclusions: All studies included in this systematic review.had a low level of evidence (4 and 5). Still, the potential role of VZV in the etiopathogenesis of periapical pathoses and root resorption cannot be ruled out. Future investigations should be directed toward the analysis of VZV pathologic effects on pulp blood vessels, which might cause local ischemia and tissue necrosis.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review
VL  - 43
IS  - 8
SP  - 1230
EP  - 1236
DO  - 10.1016/j.joen.2017.04.021
ER  - 

@article{
author = "Jakovljević, Aleksandar and Kuzmanović, Jovana and Dragan, Irina E. and Knežević, Aleksandra and Miletić, Maja and Beljić-Ivanović, Katarina and Milašin, Jelena and Andrić, Miroslav",
year = "2017",
abstract = "Introduction: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies. Methods: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus. A qualitative critical appraisal of the included articles was performed. Results: The electronic database search. yielded 66 hits from PubMed, 73 hits from Web of Science, and 107 from Scopus: Seven case reports and 3 cross-sectional studies were included in the final review. When summarized, in 7 patients with a history of a previous HZ attack and with no other apparent cause, -23 teeth were diagnosed with apical periodontitis, 8 teeth with internal and 1 tooth with external root resorption. The cross-sectional studies investigated the presence of VZV DNA in samples of acute apical abscess. The VZV DNA was found only in 2 of 65 samples. Conclusions: All studies included in this systematic review.had a low level of evidence (4 and 5). Still, the potential role of VZV in the etiopathogenesis of periapical pathoses and root resorption cannot be ruled out. Future investigations should be directed toward the analysis of VZV pathologic effects on pulp blood vessels, which might cause local ischemia and tissue necrosis.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review",
volume = "43",
number = "8",
pages = "1230-1236",
doi = "10.1016/j.joen.2017.04.021"
}

Jakovljević, A., Kuzmanović, J., Dragan, I. E., Knežević, A., Miletić, M., Beljić-Ivanović, K., Milašin, J.,& Andrić, M.. (2017). The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review. in Journal of Endodontics
Elsevier Science Inc, New York., 43(8), 1230-1236.
https://doi.org/10.1016/j.joen.2017.04.021

Jakovljević A, Kuzmanović J, Dragan IE, Knežević A, Miletić M, Beljić-Ivanović K, Milašin J, Andrić M. The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review. in Journal of Endodontics. 2017;43(8):1230-1236.
doi:10.1016/j.joen.2017.04.021 .

Jakovljević, Aleksandar, Kuzmanović, Jovana, Dragan, Irina E., Knežević, Aleksandra, Miletić, Maja, Beljić-Ivanović, Katarina, Milašin, Jelena, Andrić, Miroslav, "The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review" in Journal of Endodontics, 43, no. 8 (2017):1230-1236,
https://doi.org/10.1016/j.joen.2017.04.021 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Perunović, Neda
AU  - Nikolić, Nadja
AU  - Milašin, Jelena
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2189
AB  - The aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. Fifty samples obtained with paper points (30 from pericoronitis and 20 controls) were subjected to polymerase chain reaction (PCR) analysis. A single-stage and nested PCR assays were used to detect herpesviruses: human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) and six periodontopathic anaerobic bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Parvimonas micra, Treponema denticola, and Tannarella forsythia. Pericoronitis samples harbored HCMV and EBV at significantly higher rates than the control group (70 vs. 40 % and 46.7 vs. 15 %, P = 0.035, P = 0.021, respectively). P. micra and T. forsythia (66.7 vs. 0 %, and 40 vs. 10 %, P = 0.001, P = 0.021, respectively) were significantly more common in pericoronitis compared to the control group. Multivariate logistic regression analysis showed that the presence of T. forsythia was associated with pericoronitis development (OR 7.3, 95 % CI, 1.2-43.2, P = 0.028). The occurrence of HCVM and EBV extends our previous knowledge on microbiota in pericoronitis. These PCR-based findings demonstrated that bacterial and viral DNA occurred concomitantly in pericoronitis samples. T. forsythia appeared to be significantly associated with pericoronitis development in the examined sample. Herpesviral-bacterial co-infections might exacerbate the progression of pericoronitis.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Herpesviral-bacterial co-infection in mandibular third molar pericoronitis
VL  - 21
IS  - 5
SP  - 1639
EP  - 1646
DO  - 10.1007/s00784-016-1955-4
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Miličić, Biljana and Beljić-Ivanović, Katarina and Perunović, Neda and Nikolić, Nadja and Milašin, Jelena",
year = "2017",
abstract = "The aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. Fifty samples obtained with paper points (30 from pericoronitis and 20 controls) were subjected to polymerase chain reaction (PCR) analysis. A single-stage and nested PCR assays were used to detect herpesviruses: human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) and six periodontopathic anaerobic bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Parvimonas micra, Treponema denticola, and Tannarella forsythia. Pericoronitis samples harbored HCMV and EBV at significantly higher rates than the control group (70 vs. 40 % and 46.7 vs. 15 %, P = 0.035, P = 0.021, respectively). P. micra and T. forsythia (66.7 vs. 0 %, and 40 vs. 10 %, P = 0.001, P = 0.021, respectively) were significantly more common in pericoronitis compared to the control group. Multivariate logistic regression analysis showed that the presence of T. forsythia was associated with pericoronitis development (OR 7.3, 95 % CI, 1.2-43.2, P = 0.028). The occurrence of HCVM and EBV extends our previous knowledge on microbiota in pericoronitis. These PCR-based findings demonstrated that bacterial and viral DNA occurred concomitantly in pericoronitis samples. T. forsythia appeared to be significantly associated with pericoronitis development in the examined sample. Herpesviral-bacterial co-infections might exacerbate the progression of pericoronitis.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Herpesviral-bacterial co-infection in mandibular third molar pericoronitis",
volume = "21",
number = "5",
pages = "1639-1646",
doi = "10.1007/s00784-016-1955-4"
}

Jakovljević, A., Andrić, M., Knežević, A., Miličić, B., Beljić-Ivanović, K., Perunović, N., Nikolić, N.,& Milašin, J.. (2017). Herpesviral-bacterial co-infection in mandibular third molar pericoronitis. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 21(5), 1639-1646.
https://doi.org/10.1007/s00784-016-1955-4

Jakovljević A, Andrić M, Knežević A, Miličić B, Beljić-Ivanović K, Perunović N, Nikolić N, Milašin J. Herpesviral-bacterial co-infection in mandibular third molar pericoronitis. in Clinical Oral Investigations. 2017;21(5):1639-1646.
doi:10.1007/s00784-016-1955-4 .

Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Miličić, Biljana, Beljić-Ivanović, Katarina, Perunović, Neda, Nikolić, Nadja, Milašin, Jelena, "Herpesviral-bacterial co-infection in mandibular third molar pericoronitis" in Clinical Oral Investigations, 21, no. 5 (2017):1639-1646,
https://doi.org/10.1007/s00784-016-1955-4 . .

TY  - CHAP
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Jovanović, Tanja
AU  - Kesić, Ljiljana
AU  - Milasin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2597
AB  - Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.
PB  - Rijeka : InTech
T2  - Herpesviridae
T1  - Herpesviruses in Periapical Pathoses: An Updated Systematic Review
SP  - 31
EP  - 74
DO  - 10.5772/64004
ER  - 

@inbook{
editor = "Ongrádi, Joseph",
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Miletić, Maja and Jovanović, Tanja and Kesić, Ljiljana and Milasin, Jelena",
year = "2016",
abstract = "Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.",
publisher = "Rijeka : InTech",
journal = "Herpesviridae",
booktitle = "Herpesviruses in Periapical Pathoses: An Updated Systematic Review",
pages = "31-74",
doi = "10.5772/64004"
}

Ongrádi, J., Jakovljević, A., Andrić, M., Knežević, A., Beljić-Ivanović, K., Miletić, M., Jovanović, T., Kesić, L.,& Milasin, J.. (2016). Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae
Rijeka : InTech., 31-74.
https://doi.org/10.5772/64004

Ongrádi J, Jakovljević A, Andrić M, Knežević A, Beljić-Ivanović K, Miletić M, Jovanović T, Kesić L, Milasin J. Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae. 2016;:31-74.
doi:10.5772/64004 .

Ongrádi, Joseph, Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Miletić, Maja, Jovanović, Tanja, Kesić, Ljiljana, Milasin, Jelena, "Herpesviruses in Periapical Pathoses: An Updated Systematic Review" in Herpesviridae (2016):31-74,
https://doi.org/10.5772/64004 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Knežević, Aleksandra
AU  - Mojsilović, Slavko
AU  - Milašin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2147
AB  - Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.
PB  - Churchill Livingstone, Edinburgh
T2  - Medical Hypotheses
T1  - Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species
VL  - 94
SP  - 40
EP  - 42
DO  - 10.1016/j.mehy.2016.06.020
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Miletić, Maja and Beljić-Ivanović, Katarina and Knežević, Aleksandra and Mojsilović, Slavko and Milašin, Jelena",
year = "2016",
abstract = "Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Medical Hypotheses",
title = "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species",
volume = "94",
pages = "40-42",
doi = "10.1016/j.mehy.2016.06.020"
}

Jakovljević, A., Andrić, M., Miletić, M., Beljić-Ivanović, K., Knežević, A., Mojsilović, S.,& Milašin, J.. (2016). Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses
Churchill Livingstone, Edinburgh., 94, 40-42.
https://doi.org/10.1016/j.mehy.2016.06.020

Jakovljević A, Andrić M, Miletić M, Beljić-Ivanović K, Knežević A, Mojsilović S, Milašin J. Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses. 2016;94:40-42.
doi:10.1016/j.mehy.2016.06.020 .

Jakovljević, Aleksandar, Andrić, Miroslav, Miletić, Maja, Beljić-Ivanović, Katarina, Knežević, Aleksandra, Mojsilović, Slavko, Milašin, Jelena, "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species" in Medical Hypotheses, 94 (2016):40-42,
https://doi.org/10.1016/j.mehy.2016.06.020 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Soldatović, Ivan
AU  - Nikolić, Nadja
AU  - Karalić, Danijela
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1996
AB  - Introduction: Different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) possess specific pathogenic abilities because of various interactions with the host's immune system and differences in cell tropism. The aim of this study was to determine the distribution of HCMV and EBV genotypes in apical periodontitis lesions in relation to their clinical and histopathologic features. Methods: One hundred samples of apical periodontitis lesions and 25 control samples (healthy pulp tissue) were collected. The presence of HCMV glycoprotein B (gB) and EBV nuclear antigen-2 genotypes was analyzed by nested polymerase chain reaction and restriction fragment length polymorphisms analysis. Results: EBV and HCMV were detected in apical periodontitis lesions at significantly higher frequencies than in healthy pulp controls (P = .020 and P = .020, respectively). HCMV gB type II was significantly more frequent compared with gB type I in the examined groups (P = .036). No HCMV gB type III or IV products were found. In both periapical lesions and controls, EBV-1 occurred more often compared with EBV-2 (P = .001). Dual EBV and HCMV coinfection was more frequently detected in large-size periapical lesions (P = .038). Conclusions: Both HCMV and EBV are associated with inflammatory processes of periapical bone destruction. HCMV gB type II and EBV-1 are the most prevalent genotypes in apical periodontitis lesions.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions
VL  - 41
IS  - 11
SP  - 1847
EP  - 1851
DO  - 10.1016/j.joen.2015.08.027
ER  - 

@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Soldatović, Ivan and Nikolić, Nadja and Karalić, Danijela and Milašin, Jelena",
year = "2015",
abstract = "Introduction: Different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) possess specific pathogenic abilities because of various interactions with the host's immune system and differences in cell tropism. The aim of this study was to determine the distribution of HCMV and EBV genotypes in apical periodontitis lesions in relation to their clinical and histopathologic features. Methods: One hundred samples of apical periodontitis lesions and 25 control samples (healthy pulp tissue) were collected. The presence of HCMV glycoprotein B (gB) and EBV nuclear antigen-2 genotypes was analyzed by nested polymerase chain reaction and restriction fragment length polymorphisms analysis. Results: EBV and HCMV were detected in apical periodontitis lesions at significantly higher frequencies than in healthy pulp controls (P = .020 and P = .020, respectively). HCMV gB type II was significantly more frequent compared with gB type I in the examined groups (P = .036). No HCMV gB type III or IV products were found. In both periapical lesions and controls, EBV-1 occurred more often compared with EBV-2 (P = .001). Dual EBV and HCMV coinfection was more frequently detected in large-size periapical lesions (P = .038). Conclusions: Both HCMV and EBV are associated with inflammatory processes of periapical bone destruction. HCMV gB type II and EBV-1 are the most prevalent genotypes in apical periodontitis lesions.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions",
volume = "41",
number = "11",
pages = "1847-1851",
doi = "10.1016/j.joen.2015.08.027"
}

Jakovljević, A., Andrić, M., Knežević, A., Soldatović, I., Nikolić, N., Karalić, D.,& Milašin, J.. (2015). Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions. in Journal of Endodontics
Elsevier Science Inc, New York., 41(11), 1847-1851.
https://doi.org/10.1016/j.joen.2015.08.027

Jakovljević A, Andrić M, Knežević A, Soldatović I, Nikolić N, Karalić D, Milašin J. Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions. in Journal of Endodontics. 2015;41(11):1847-1851.
doi:10.1016/j.joen.2015.08.027 .

Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Soldatović, Ivan, Nikolić, Nadja, Karalić, Danijela, Milašin, Jelena, "Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions" in Journal of Endodontics, 41, no. 11 (2015):1847-1851,
https://doi.org/10.1016/j.joen.2015.08.027 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Knežević, Aleksandra
AU  - Karalić, Danijela
AU  - Soldatović, Ivan
AU  - Popović, Branka
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1986
AB  - This study aimed to compare the levels of tumour necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1) and interleukin-6 (IL-6) between apical periodontitis lesions with different clinical and histological features. Based on clinical data and history of disease, 100 human apical periodontitis lesions were categorised as either asymptomatic or symptomatic lesions. According to histological examination, lesions were divided into periapical granulomas and radicular cysts. Pulp tissues of 25 impacted wisdom teeth were used as controls. Homogenised tissue samples were centrifuged and supernatants were used for the determination of cytokine levels by enzyme-linked immunosorbent assay. Significantly higher levels of IL-1 and IL-6 were found in symptomatic lesions compared with asymptomatic lesions and control tissues (P lt 0.001, P lt 0.001, respectively). The concentration of IL-1 was significantly higher in radicular cysts compared with periapical granulomas (P=0.003). Symptomatic lesions, as judged by high local production of IL-1 and IL-6, represent an immunologically active stage of the disease.
PB  - Wiley, Hoboken
T2  - Australian Endodontic Journal
T1  - Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings
VL  - 41
IS  - 2
SP  - 72
EP  - 77
DO  - 10.1111/aej.12072
ER  - 

@article{
author = "Jakovljević, Aleksandar and Knežević, Aleksandra and Karalić, Danijela and Soldatović, Ivan and Popović, Branka and Milašin, Jelena and Andrić, Miroslav",
year = "2015",
abstract = "This study aimed to compare the levels of tumour necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1) and interleukin-6 (IL-6) between apical periodontitis lesions with different clinical and histological features. Based on clinical data and history of disease, 100 human apical periodontitis lesions were categorised as either asymptomatic or symptomatic lesions. According to histological examination, lesions were divided into periapical granulomas and radicular cysts. Pulp tissues of 25 impacted wisdom teeth were used as controls. Homogenised tissue samples were centrifuged and supernatants were used for the determination of cytokine levels by enzyme-linked immunosorbent assay. Significantly higher levels of IL-1 and IL-6 were found in symptomatic lesions compared with asymptomatic lesions and control tissues (P lt 0.001, P lt 0.001, respectively). The concentration of IL-1 was significantly higher in radicular cysts compared with periapical granulomas (P=0.003). Symptomatic lesions, as judged by high local production of IL-1 and IL-6, represent an immunologically active stage of the disease.",
publisher = "Wiley, Hoboken",
journal = "Australian Endodontic Journal",
title = "Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings",
volume = "41",
number = "2",
pages = "72-77",
doi = "10.1111/aej.12072"
}

Jakovljević, A., Knežević, A., Karalić, D., Soldatović, I., Popović, B., Milašin, J.,& Andrić, M.. (2015). Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings. in Australian Endodontic Journal
Wiley, Hoboken., 41(2), 72-77.
https://doi.org/10.1111/aej.12072

Jakovljević A, Knežević A, Karalić D, Soldatović I, Popović B, Milašin J, Andrić M. Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings. in Australian Endodontic Journal. 2015;41(2):72-77.
doi:10.1111/aej.12072 .

Jakovljević, Aleksandar, Knežević, Aleksandra, Karalić, Danijela, Soldatović, Ivan, Popović, Branka, Milašin, Jelena, Andrić, Miroslav, "Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings" in Australian Endodontic Journal, 41, no. 2 (2015):72-77,
https://doi.org/10.1111/aej.12072 . .

TY  - JOUR
AU  - Bukvić, B.
AU  - Šipetić, Sandra
AU  - Kalezić, Nevena
AU  - Diklić, Aleksandar
AU  - Paunović, Ivan
AU  - Kovačević, Bojan
AU  - Knežević, Aleksandra
AU  - Živaljević, Vladan
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1631
AB  - Purpose: Thyroid cancer patients have favorable prognosis. The aim of this study was to analyze changing trends in mortality of thyroid cancer in Belgrade, during the period between 1987 and 2006 Methods: Mortality data were obtained from the Belgrade Office of Statistics. Mortality rates per 100,000 inhabitants were standardized according to the Segi's world population. Regression analysis was used to estimate the thyroid cancer mortality trend for the period 1987-2006. Results: The average percent of deaths due to thyroid cancer among all deaths was almost 2-fold higher in females (0.11%) than in males (0.6%), as well as among deaths due to all malignancies (females 0.54% and males 0.27%). During this 20-year period, the average standardized mortality rate was 1.5 times higher in females (0.74 per 100.000) than in males (0.51 per 100.000). In the observed period, the mortality rates for thyroid cancer were increased (+0.40%) in women and decreased (-0.42%) in men. In particular, in the 60-69 years age group in males, a significant trend for mortality decrease of 3.5%/year was detected. Conclusion: Belgrade is classified in the regions with low risk of dying due to thyroid malignancies. The increasing trend of thyroid cancer mortality in females during the examined period calls for improvement of methods for early detection of disease and differential diagnosis of thyroid nodules, so that surgical treatment of thyroid cancer could be performed at a stage when it is not life threatening.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Changing trends in mortality of thyroid cancer in Belgrade population
VL  - 16
IS  - 2
SP  - 337
EP  - 340
UR  - https://hdl.handle.net/21.15107/rcub_smile_1631
ER  - 

@article{
author = "Bukvić, B. and Šipetić, Sandra and Kalezić, Nevena and Diklić, Aleksandar and Paunović, Ivan and Kovačević, Bojan and Knežević, Aleksandra and Živaljević, Vladan",
year = "2011",
abstract = "Purpose: Thyroid cancer patients have favorable prognosis. The aim of this study was to analyze changing trends in mortality of thyroid cancer in Belgrade, during the period between 1987 and 2006 Methods: Mortality data were obtained from the Belgrade Office of Statistics. Mortality rates per 100,000 inhabitants were standardized according to the Segi's world population. Regression analysis was used to estimate the thyroid cancer mortality trend for the period 1987-2006. Results: The average percent of deaths due to thyroid cancer among all deaths was almost 2-fold higher in females (0.11%) than in males (0.6%), as well as among deaths due to all malignancies (females 0.54% and males 0.27%). During this 20-year period, the average standardized mortality rate was 1.5 times higher in females (0.74 per 100.000) than in males (0.51 per 100.000). In the observed period, the mortality rates for thyroid cancer were increased (+0.40%) in women and decreased (-0.42%) in men. In particular, in the 60-69 years age group in males, a significant trend for mortality decrease of 3.5%/year was detected. Conclusion: Belgrade is classified in the regions with low risk of dying due to thyroid malignancies. The increasing trend of thyroid cancer mortality in females during the examined period calls for improvement of methods for early detection of disease and differential diagnosis of thyroid nodules, so that surgical treatment of thyroid cancer could be performed at a stage when it is not life threatening.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Changing trends in mortality of thyroid cancer in Belgrade population",
volume = "16",
number = "2",
pages = "337-340",
url = "https://hdl.handle.net/21.15107/rcub_smile_1631"
}

Bukvić, B., Šipetić, S., Kalezić, N., Diklić, A., Paunović, I., Kovačević, B., Knežević, A.,& Živaljević, V.. (2011). Changing trends in mortality of thyroid cancer in Belgrade population. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 16(2), 337-340.
https://hdl.handle.net/21.15107/rcub_smile_1631

Bukvić B, Šipetić S, Kalezić N, Diklić A, Paunović I, Kovačević B, Knežević A, Živaljević V. Changing trends in mortality of thyroid cancer in Belgrade population. in Journal of BUON. 2011;16(2):337-340.
https://hdl.handle.net/21.15107/rcub_smile_1631 .

Bukvić, B., Šipetić, Sandra, Kalezić, Nevena, Diklić, Aleksandar, Paunović, Ivan, Kovačević, Bojan, Knežević, Aleksandra, Živaljević, Vladan, "Changing trends in mortality of thyroid cancer in Belgrade population" in Journal of BUON, 16, no. 2 (2011):337-340,
https://hdl.handle.net/21.15107/rcub_smile_1631 .

TY  - JOUR
AU  - Đurić, Milanko
AU  - Janković, Ljiljana
AU  - Jovanović, Tanja
AU  - Pavlica, Dušan
AU  - Brkić, Snežana
AU  - Knežević, Aleksandra
AU  - Marković, Dubravka
AU  - Milašin, Jelena
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1504
AB  - Oral reactivation of latent Herpes simplex virus (HSV) infection may easily occur in cancer patients. Virus reactivation can cause oral mucosa damage, worsen already existing lesions caused by stomatotoxic effect of cancer therapy and, whether symptomatic or asymptomatic, ample spreading and promote viral transmission. Polymerase chain reaction (PCR), cell-culture and direct immunofluorescence have been used to determine the frequency of oral HSV reactivation in 60 patients undergoing chemotherapy for different malignancies. By means of PCR, the presence of viral DNA was detected in 71.7% of patients prior to chemotherapy and in 85.0% after chemotherapy. 33.3% of patients before and 40.0% after chemotherapy were viral-culture positive, while 3.3% of patients before and 11.7% after chemotherapy were positive as shown by direct immunofluorescence. No significant difference in HSV-1 reactivation was found before and after chemotherapy. In addition, no significant difference was found when comparing HSV-1 reactivation in patients with and without mucositis. HSV-2 was not detected in any of the patients. Reactivation of latent HSV is exceptionally frequent in cancer patients. The results of this study suggest that virus reactivation occurs independently of cancer chemotherapy. The potential role of HSV reactivation in oral mucosa damage remains unclear.
PB  - Wiley, Hoboken
T2  - Journal of Oral Pathology & Medicine
T1  - Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection
VL  - 38
IS  - 2
SP  - 167
EP  - 173
DO  - 10.1111/j.1600-0714.2008.00684.x
ER  - 

@article{
author = "Đurić, Milanko and Janković, Ljiljana and Jovanović, Tanja and Pavlica, Dušan and Brkić, Snežana and Knežević, Aleksandra and Marković, Dubravka and Milašin, Jelena",
year = "2009",
abstract = "Oral reactivation of latent Herpes simplex virus (HSV) infection may easily occur in cancer patients. Virus reactivation can cause oral mucosa damage, worsen already existing lesions caused by stomatotoxic effect of cancer therapy and, whether symptomatic or asymptomatic, ample spreading and promote viral transmission. Polymerase chain reaction (PCR), cell-culture and direct immunofluorescence have been used to determine the frequency of oral HSV reactivation in 60 patients undergoing chemotherapy for different malignancies. By means of PCR, the presence of viral DNA was detected in 71.7% of patients prior to chemotherapy and in 85.0% after chemotherapy. 33.3% of patients before and 40.0% after chemotherapy were viral-culture positive, while 3.3% of patients before and 11.7% after chemotherapy were positive as shown by direct immunofluorescence. No significant difference in HSV-1 reactivation was found before and after chemotherapy. In addition, no significant difference was found when comparing HSV-1 reactivation in patients with and without mucositis. HSV-2 was not detected in any of the patients. Reactivation of latent HSV is exceptionally frequent in cancer patients. The results of this study suggest that virus reactivation occurs independently of cancer chemotherapy. The potential role of HSV reactivation in oral mucosa damage remains unclear.",
publisher = "Wiley, Hoboken",
journal = "Journal of Oral Pathology & Medicine",
title = "Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection",
volume = "38",
number = "2",
pages = "167-173",
doi = "10.1111/j.1600-0714.2008.00684.x"
}

Đurić, M., Janković, L., Jovanović, T., Pavlica, D., Brkić, S., Knežević, A., Marković, D.,& Milašin, J.. (2009). Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection. in Journal of Oral Pathology & Medicine
Wiley, Hoboken., 38(2), 167-173.
https://doi.org/10.1111/j.1600-0714.2008.00684.x

Đurić M, Janković L, Jovanović T, Pavlica D, Brkić S, Knežević A, Marković D, Milašin J. Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection. in Journal of Oral Pathology & Medicine. 2009;38(2):167-173.
doi:10.1111/j.1600-0714.2008.00684.x .

Đurić, Milanko, Janković, Ljiljana, Jovanović, Tanja, Pavlica, Dušan, Brkić, Snežana, Knežević, Aleksandra, Marković, Dubravka, Milašin, Jelena, "Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection" in Journal of Oral Pathology & Medicine, 38, no. 2 (2009):167-173,
https://doi.org/10.1111/j.1600-0714.2008.00684.x . .

TY  - JOUR
AU  - Marković, Dejan
AU  - Mirković, B.
AU  - Jovanović, T.
AU  - Knežević, Aleksandra
AU  - Nastovski, T.
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1353
AB  - Essential oils are widely used in medicine, dentistry and cosmetology as flavour and odour corrigents in various substances for oral hygiene. The aim of this study was to present comprehensively the possibilities for application of Melaleuca Alternifolia essential oil in dentistry based on the analysis of contemporary scientific and professional publications. The application of Tea tree essential oil in the treatment of periodontal, fungal and viral diseases is very efficient. The study of antimicrobial potential of ten different essential oils confirmed the efficiency of Tea tree oil against numerous Gram+ and Gram- bacteria. In vitro studies of bacteriostatic, bactericidal and fungicidal effect of Tea tree oil solution against ten different microorganisms confirmed sensitivity of the following microorganisms: Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Porphyromonas gingivalis, and slightly weaker effect against Streptococcus Mutans and Prevotella intermedia. Tea tree is very effective in the treatment of various diseases and is an introduction and momentum for the application of plant substances in the treatment of numerous diseases in dentistry. .
AB  - Etarska ulja imaju široku primenu u medicini, stomatologiji i kozmetologiji, kao korigensi ukusa i mirisa različitih sredstava za oralnu higijenu. Cilj ovog rada je bio da se kroz analizu aktuelnih naučnih i stručnih publikacija sveobuhvatno prikažu mogućnosti primene etarskog ulja Melaleuca Alternifolia u stomatologiji. Primena etarskog ulja čajnog drveta u lečenju parodontopatije, gljivičnih oboljenja, kao i u terapiji virusnih infekcija, se pokazala izuzetno efikasnom. Ispitivanjem antimikrobnog dejstva deset različitih etarskih ulja, potvrđeno je da je etarsko ulje čajnog drveta vrlo efikasno protiv niza Gram + i Gram - bakterija. In vitro ispitivanja bakteriostatskog, baktericidnog i fungicidnog delovanja rastvora ulja čajnog drveta na deset različitih mikroorganizama su potvrdila osetljivost sledećih mikroorganizama: Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum i Porphyromonas gingivalis, i nešto slabije prema bakterijama Streptococcus Mutans i Prevotella intermedia. Čajno drvo se pokazalo izuzetno blagotvornim u lečenju različitih oboljenja i predstavlja uvod i podstrek za primenu biljnih preparata u lečenju brojnih manifestacija kod različitih oboljenja u stomatologiji. .
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - The application of tea tree essential oil in dentistry
T1  - Primena etarskog ulja čajnog drveta u stomatologiji
VL  - 54
IS  - 2
SP  - 106
EP  - 114
DO  - 10.2298/SGS0702106M
ER  - 

@article{
author = "Marković, Dejan and Mirković, B. and Jovanović, T. and Knežević, Aleksandra and Nastovski, T.",
year = "2007",
abstract = "Essential oils are widely used in medicine, dentistry and cosmetology as flavour and odour corrigents in various substances for oral hygiene. The aim of this study was to present comprehensively the possibilities for application of Melaleuca Alternifolia essential oil in dentistry based on the analysis of contemporary scientific and professional publications. The application of Tea tree essential oil in the treatment of periodontal, fungal and viral diseases is very efficient. The study of antimicrobial potential of ten different essential oils confirmed the efficiency of Tea tree oil against numerous Gram+ and Gram- bacteria. In vitro studies of bacteriostatic, bactericidal and fungicidal effect of Tea tree oil solution against ten different microorganisms confirmed sensitivity of the following microorganisms: Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Porphyromonas gingivalis, and slightly weaker effect against Streptococcus Mutans and Prevotella intermedia. Tea tree is very effective in the treatment of various diseases and is an introduction and momentum for the application of plant substances in the treatment of numerous diseases in dentistry. ., Etarska ulja imaju široku primenu u medicini, stomatologiji i kozmetologiji, kao korigensi ukusa i mirisa različitih sredstava za oralnu higijenu. Cilj ovog rada je bio da se kroz analizu aktuelnih naučnih i stručnih publikacija sveobuhvatno prikažu mogućnosti primene etarskog ulja Melaleuca Alternifolia u stomatologiji. Primena etarskog ulja čajnog drveta u lečenju parodontopatije, gljivičnih oboljenja, kao i u terapiji virusnih infekcija, se pokazala izuzetno efikasnom. Ispitivanjem antimikrobnog dejstva deset različitih etarskih ulja, potvrđeno je da je etarsko ulje čajnog drveta vrlo efikasno protiv niza Gram + i Gram - bakterija. In vitro ispitivanja bakteriostatskog, baktericidnog i fungicidnog delovanja rastvora ulja čajnog drveta na deset različitih mikroorganizama su potvrdila osetljivost sledećih mikroorganizama: Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum i Porphyromonas gingivalis, i nešto slabije prema bakterijama Streptococcus Mutans i Prevotella intermedia. Čajno drvo se pokazalo izuzetno blagotvornim u lečenju različitih oboljenja i predstavlja uvod i podstrek za primenu biljnih preparata u lečenju brojnih manifestacija kod različitih oboljenja u stomatologiji. .",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "The application of tea tree essential oil in dentistry, Primena etarskog ulja čajnog drveta u stomatologiji",
volume = "54",
number = "2",
pages = "106-114",
doi = "10.2298/SGS0702106M"
}

Marković, D., Mirković, B., Jovanović, T., Knežević, A.,& Nastovski, T.. (2007). The application of tea tree essential oil in dentistry. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 54(2), 106-114.
https://doi.org/10.2298/SGS0702106M

Marković D, Mirković B, Jovanović T, Knežević A, Nastovski T. The application of tea tree essential oil in dentistry. in Stomatološki glasnik Srbije. 2007;54(2):106-114.
doi:10.2298/SGS0702106M .

Marković, Dejan, Mirković, B., Jovanović, T., Knežević, Aleksandra, Nastovski, T., "The application of tea tree essential oil in dentistry" in Stomatološki glasnik Srbije, 54, no. 2 (2007):106-114,
https://doi.org/10.2298/SGS0702106M . .

TY  - JOUR
AU  - Jovanović, Tanja
AU  - Pavlica, Dušan
AU  - Knežević, Aleksandra
AU  - Lazarević, Ivana B.
PY  - 2004
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1211
AB  - It is well known that the most of AIDS patient have evidence of more severe herpetic infection than immunocompetent persons. In this study we examined the characteristics of humoral immune response during active herpes simplex virus infection in immunocompetent and immunocompromised patients, and correlate the value of specific markers (titre of specific anti-HSV-IgM, anti-HSV-IgG antibody, titre of neutralization antibody and avidity of IgG) between these 2 groups. The results have shown that although AIDS patients have severe depression of their cellular immune response, they can mount an intensive humoral antiviral response during the active HSV-1 infection. They have higher titre and avidity of specific anti-HSV antibody than immunocompetent persons. But even with high titre of specific antibody, AIDS patient have no enough neutralizing antibodies. According to the clinical manifestation of herpetic infection in AIDS patient, our result showed significant association between the quantity of in vitro neutralizing activity and in vivo protection from severe herpetic infection.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Stomatology
T1  - Virus specific humoral immune response to Herpes Simplex Virus (HSV) in AIDS patients with oropharyngeal herpes simplex infection
VL  - 8
IS  - 2
SP  - 96
EP  - 98
UR  - https://hdl.handle.net/21.15107/rcub_smile_1211
ER  - 

@article{
author = "Jovanović, Tanja and Pavlica, Dušan and Knežević, Aleksandra and Lazarević, Ivana B.",
year = "2004",
abstract = "It is well known that the most of AIDS patient have evidence of more severe herpetic infection than immunocompetent persons. In this study we examined the characteristics of humoral immune response during active herpes simplex virus infection in immunocompetent and immunocompromised patients, and correlate the value of specific markers (titre of specific anti-HSV-IgM, anti-HSV-IgG antibody, titre of neutralization antibody and avidity of IgG) between these 2 groups. The results have shown that although AIDS patients have severe depression of their cellular immune response, they can mount an intensive humoral antiviral response during the active HSV-1 infection. They have higher titre and avidity of specific anti-HSV antibody than immunocompetent persons. But even with high titre of specific antibody, AIDS patient have no enough neutralizing antibodies. According to the clinical manifestation of herpetic infection in AIDS patient, our result showed significant association between the quantity of in vitro neutralizing activity and in vivo protection from severe herpetic infection.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Stomatology",
title = "Virus specific humoral immune response to Herpes Simplex Virus (HSV) in AIDS patients with oropharyngeal herpes simplex infection",
volume = "8",
number = "2",
pages = "96-98",
url = "https://hdl.handle.net/21.15107/rcub_smile_1211"
}

Jovanović, T., Pavlica, D., Knežević, A.,& Lazarević, I. B.. (2004). Virus specific humoral immune response to Herpes Simplex Virus (HSV) in AIDS patients with oropharyngeal herpes simplex infection. in Balkan Journal of Stomatology
Udruženje stomatologa Balkana., 8(2), 96-98.
https://hdl.handle.net/21.15107/rcub_smile_1211

Jovanović T, Pavlica D, Knežević A, Lazarević IB. Virus specific humoral immune response to Herpes Simplex Virus (HSV) in AIDS patients with oropharyngeal herpes simplex infection. in Balkan Journal of Stomatology. 2004;8(2):96-98.
https://hdl.handle.net/21.15107/rcub_smile_1211 .

Jovanović, Tanja, Pavlica, Dušan, Knežević, Aleksandra, Lazarević, Ivana B., "Virus specific humoral immune response to Herpes Simplex Virus (HSV) in AIDS patients with oropharyngeal herpes simplex infection" in Balkan Journal of Stomatology, 8, no. 2 (2004):96-98,
https://hdl.handle.net/21.15107/rcub_smile_1211 .