TY  - JOUR
AU  - Vuković, Rade
AU  - Milenković, Tatjana
AU  - Mitrović, Katarina
AU  - Todorović, Slađana
AU  - Plavsić, Ljiljana
AU  - Vuković, Ana
AU  - Zdravković, Dragan
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2010
AB  - Available data on metabolically healthy obese (MHO) phenotype in children suggest that gender, puberty, waist circumference, insulin sensitivity, and other laboratory predictors have a role in distinguishing these children from metabolically unhealthy obese (MUO) youth. The goal of this study was to identify predictors of MHO phenotype and to analyze glucose and insulin metabolism during oral glucose tolerance test (OGTT) in MHO children. OGTT was performed in 244 obese children and adolescents aged 4.6-18.9 years. Subjects were classified as MHO in case of no fulfilled criterion of metabolic syndrome except anthropometry or as MUO (a parts per thousand yen2 fulfilled criteria). Among the subjects, 21.7 % had MHO phenotype, and they were more likely to be female, younger, and in earlier stages of pubertal development, with lower degree of abdominal obesity. Insulin resistance was the only independent laboratory predictor of MUO phenotype (OR 1.59, CI 1.13-2.25), with 82 % sensitivity and 60 % specificity for diagnosing MUO using HOMA-IR cutoff point of a parts per thousand yen2.85. Although no significant differences were observed in glucose regulation, MUO children had higher insulin demand throughout OGTT, with 1.53 times higher total insulin secretion. Conclusion: Further research is needed to investigate the possibility of targeted treatment of insulin resistance to minimize pubertal cross-over to MUO in obese children.
PB  - Springer, New York
T2  - European Journal of Pediatrics
T1  - Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents
VL  - 174
IS  - 12
SP  - 1649
EP  - 1655
DO  - 10.1007/s00431-015-2587-4
ER  - 

@article{
author = "Vuković, Rade and Milenković, Tatjana and Mitrović, Katarina and Todorović, Slađana and Plavsić, Ljiljana and Vuković, Ana and Zdravković, Dragan",
year = "2015",
abstract = "Available data on metabolically healthy obese (MHO) phenotype in children suggest that gender, puberty, waist circumference, insulin sensitivity, and other laboratory predictors have a role in distinguishing these children from metabolically unhealthy obese (MUO) youth. The goal of this study was to identify predictors of MHO phenotype and to analyze glucose and insulin metabolism during oral glucose tolerance test (OGTT) in MHO children. OGTT was performed in 244 obese children and adolescents aged 4.6-18.9 years. Subjects were classified as MHO in case of no fulfilled criterion of metabolic syndrome except anthropometry or as MUO (a parts per thousand yen2 fulfilled criteria). Among the subjects, 21.7 % had MHO phenotype, and they were more likely to be female, younger, and in earlier stages of pubertal development, with lower degree of abdominal obesity. Insulin resistance was the only independent laboratory predictor of MUO phenotype (OR 1.59, CI 1.13-2.25), with 82 % sensitivity and 60 % specificity for diagnosing MUO using HOMA-IR cutoff point of a parts per thousand yen2.85. Although no significant differences were observed in glucose regulation, MUO children had higher insulin demand throughout OGTT, with 1.53 times higher total insulin secretion. Conclusion: Further research is needed to investigate the possibility of targeted treatment of insulin resistance to minimize pubertal cross-over to MUO in obese children.",
publisher = "Springer, New York",
journal = "European Journal of Pediatrics",
title = "Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents",
volume = "174",
number = "12",
pages = "1649-1655",
doi = "10.1007/s00431-015-2587-4"
}

Vuković, R., Milenković, T., Mitrović, K., Todorović, S., Plavsić, L., Vuković, A.,& Zdravković, D.. (2015). Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents. in European Journal of Pediatrics
Springer, New York., 174(12), 1649-1655.
https://doi.org/10.1007/s00431-015-2587-4

Vuković R, Milenković T, Mitrović K, Todorović S, Plavsić L, Vuković A, Zdravković D. Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents. in European Journal of Pediatrics. 2015;174(12):1649-1655.
doi:10.1007/s00431-015-2587-4 .

Vuković, Rade, Milenković, Tatjana, Mitrović, Katarina, Todorović, Slađana, Plavsić, Ljiljana, Vuković, Ana, Zdravković, Dragan, "Preserved insulin sensitivity predicts metabolically healthy obese phenotype in children and adolescents" in European Journal of Pediatrics, 174, no. 12 (2015):1649-1655,
https://doi.org/10.1007/s00431-015-2587-4 . .