TY  - JOUR
AU  - Milošević-Marković, Maja
AU  - Lazarević, Miloš
AU  - Toljić, Boško
AU  - Petrović, Milan
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Aničić, Boban
AU  - Jelovac, Drago
AU  - Jovanović, Svetlana
AU  - Milašin, Jelena
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3283
AB  - Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.
PB  - TECH SCIENCE PRESS
T2  - BIOCELL
T1  - Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential
VL  - 45
IS  - 6
SP  - 1543
EP  - 1550
DO  - 10.32604/biocell.2021.015060
ER  - 

@article{
author = "Milošević-Marković, Maja and Lazarević, Miloš and Toljić, Boško and Petrović, Milan and Vukadinović, Miroslav and Jezdić, Zoran and Aničić, Boban and Jelovac, Drago and Jovanović, Svetlana and Milašin, Jelena",
year = "2021",
abstract = "Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.",
publisher = "TECH SCIENCE PRESS",
journal = "BIOCELL",
title = "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential",
volume = "45",
number = "6",
pages = "1543-1550",
doi = "10.32604/biocell.2021.015060"
}

Milošević-Marković, M., Lazarević, M., Toljić, B., Petrović, M., Vukadinović, M., Jezdić, Z., Aničić, B., Jelovac, D., Jovanović, S.,& Milašin, J.. (2021). Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential. in BIOCELL
TECH SCIENCE PRESS., 45(6), 1543-1550.
https://doi.org/10.32604/biocell.2021.015060

Milošević-Marković M, Lazarević M, Toljić B, Petrović M, Vukadinović M, Jezdić Z, Aničić B, Jelovac D, Jovanović S, Milašin J. Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential. in BIOCELL. 2021;45(6):1543-1550.
doi:10.32604/biocell.2021.015060 .

Milošević-Marković, Maja, Lazarević, Miloš, Toljić, Boško, Petrović, Milan, Vukadinović, Miroslav, Jezdić, Zoran, Aničić, Boban, Jelovac, Drago, Jovanović, Svetlana, Milašin, Jelena, "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential" in BIOCELL, 45, no. 6 (2021):1543-1550,
https://doi.org/10.32604/biocell.2021.015060 . .

TY  - JOUR
AU  - Petrović, Milan
AU  - Jelovac, Drago
AU  - Antić, Svetlana
AU  - Antunović, Marija
AU  - Lukić, Nikola
AU  - Sabani, Melvil
AU  - Mudrak, Joerg
AU  - Jezdić, Zoran
AU  - Pucar, Ana
AU  - Stefanović, Aleksandar
AU  - Kuzmanović, Čedomir
AU  - Nikolić, Danilo
AU  - Konstantinović, Vitomir
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2443
AB  - This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality. MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively. MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously. Stages I, II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively. Mandible was affected in 23 (72%) patients. MRONJ was treated in our department by conservative and surgical modality. In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group. The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome. Comprehensive treatment protocol and further randomized studies are necessary for further improvements.
PB  - Hindawi Ltd, London
T2  - Biomed Research International
T1  - Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies
VL  - 2019
DO  - 10.1155/2019/8345309
ER  - 

@article{
author = "Petrović, Milan and Jelovac, Drago and Antić, Svetlana and Antunović, Marija and Lukić, Nikola and Sabani, Melvil and Mudrak, Joerg and Jezdić, Zoran and Pucar, Ana and Stefanović, Aleksandar and Kuzmanović, Čedomir and Nikolić, Danilo and Konstantinović, Vitomir",
year = "2019",
abstract = "This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality. MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively. MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously. Stages I, II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively. Mandible was affected in 23 (72%) patients. MRONJ was treated in our department by conservative and surgical modality. In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group. The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome. Comprehensive treatment protocol and further randomized studies are necessary for further improvements.",
publisher = "Hindawi Ltd, London",
journal = "Biomed Research International",
title = "Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies",
volume = "2019",
doi = "10.1155/2019/8345309"
}

Petrović, M., Jelovac, D., Antić, S., Antunović, M., Lukić, N., Sabani, M., Mudrak, J., Jezdić, Z., Pucar, A., Stefanović, A., Kuzmanović, Č., Nikolić, D.,& Konstantinović, V.. (2019). Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. in Biomed Research International
Hindawi Ltd, London., 2019.
https://doi.org/10.1155/2019/8345309

Petrović M, Jelovac D, Antić S, Antunović M, Lukić N, Sabani M, Mudrak J, Jezdić Z, Pucar A, Stefanović A, Kuzmanović Č, Nikolić D, Konstantinović V. Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. in Biomed Research International. 2019;2019.
doi:10.1155/2019/8345309 .

Petrović, Milan, Jelovac, Drago, Antić, Svetlana, Antunović, Marija, Lukić, Nikola, Sabani, Melvil, Mudrak, Joerg, Jezdić, Zoran, Pucar, Ana, Stefanović, Aleksandar, Kuzmanović, Čedomir, Nikolić, Danilo, Konstantinović, Vitomir, "Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies" in Biomed Research International, 2019 (2019),
https://doi.org/10.1155/2019/8345309 . .

TY  - JOUR
AU  - Lisul, Bogdan
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Tepavčević, Zvezdana
AU  - Koruga, Đuro
AU  - Grga, Đurica
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2424
AB  - PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.
PB  - Springer Heidelberg, Heidelberg
T2  - Journal of Medical & Biological Engineering
T1  - Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins
VL  - 39
IS  - 6
SP  - 874
EP  - 884
DO  - 10.1007/s40846-019-00473-y
ER  - 

@article{
author = "Lisul, Bogdan and Jelovac, Drago and Petrović, Milan and Tepavčević, Zvezdana and Koruga, Đuro and Grga, Đurica",
year = "2019",
abstract = "PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Journal of Medical & Biological Engineering",
title = "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins",
volume = "39",
number = "6",
pages = "874-884",
doi = "10.1007/s40846-019-00473-y"
}

Lisul, B., Jelovac, D., Petrović, M., Tepavčević, Z., Koruga, Đ.,& Grga, Đ.. (2019). Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering
Springer Heidelberg, Heidelberg., 39(6), 874-884.
https://doi.org/10.1007/s40846-019-00473-y

Lisul B, Jelovac D, Petrović M, Tepavčević Z, Koruga Đ, Grga Đ. Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering. 2019;39(6):874-884.
doi:10.1007/s40846-019-00473-y .

Lisul, Bogdan, Jelovac, Drago, Petrović, Milan, Tepavčević, Zvezdana, Koruga, Đuro, Grga, Đurica, "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins" in Journal of Medical & Biological Engineering, 39, no. 6 (2019):874-884,
https://doi.org/10.1007/s40846-019-00473-y . .

TY  - JOUR
AU  - Brucoli, Matteo
AU  - Boffano, Paolo
AU  - Broccardo, Emanuele
AU  - Benech, Arnaldo
AU  - Corre, Pierre
AU  - Bertin, Helios
AU  - Pechalova, Petia
AU  - Pavlov, Nikolai
AU  - Petrov, Petko
AU  - Tamme, Tiia
AU  - Kopchak, Andrey
AU  - Hresko, Andrii
AU  - Shuminsky, Eugen
AU  - Dediol, Emil
AU  - Tarle, Marko
AU  - Konstantinović, Vitomir
AU  - Petrović, Milan
AU  - Holmes, Simon
AU  - Karagozoglu, Hakki K.
AU  - Forouzanfar, Tymour
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2452
AB  - Purpose: Fractures of the zygomaticomaxillary complex (ZMC) are common injuries that may lead to loss of an aesthetically pleasing appearance and functional impairment. The aim of this study was to analyze the demographics, causes, characteristics, and outcomes of zygomatic fractures managed at several European departments of oral and maxillofacial surgery. Materials and methods: This study is based on a multicenter systematic database that allowed the recording of all patients with ZMC fractures between 1 January 2013 and 31 December 2017. The following data were recorded: gender, age, personal medical history, etiology, side of zygomatic fracture, classification of ZMC fracture, associated maxillofacial fractures, symptoms at diagnosis, type of performed treatment, and sequelae/complications. Results: A total of 1406 patients (1172 males, 234 females) were included in the study. Statistically significant correlations were found between assault-related ZMC fractures and the A3 class (p  lt  .0000005) and between Infraorbital Nerve (ION) anesthesia and B class (p  lt  .00000005). Conclusion: The most frequent cause of ZMC fractures was assault, followed by falls. The most frequently involved decade of age was between 20 and 29 years. The decision and type of surgical treatment of ZMC fractures depends on several issues that need to be considered on a case by case basis.
PB  - Churchill Livingstone, Edinburgh
T2  - Journal of Cranio-Maxillofacial Surgery
T1  - The 'European zygomatic fracture' research project: The epidemiological results from a multicenter European collaboration
VL  - 47
IS  - 4
SP  - 616
EP  - 621
DO  - 10.1016/j.jcms.2019.01.026
ER  - 

@article{
author = "Brucoli, Matteo and Boffano, Paolo and Broccardo, Emanuele and Benech, Arnaldo and Corre, Pierre and Bertin, Helios and Pechalova, Petia and Pavlov, Nikolai and Petrov, Petko and Tamme, Tiia and Kopchak, Andrey and Hresko, Andrii and Shuminsky, Eugen and Dediol, Emil and Tarle, Marko and Konstantinović, Vitomir and Petrović, Milan and Holmes, Simon and Karagozoglu, Hakki K. and Forouzanfar, Tymour",
year = "2019",
abstract = "Purpose: Fractures of the zygomaticomaxillary complex (ZMC) are common injuries that may lead to loss of an aesthetically pleasing appearance and functional impairment. The aim of this study was to analyze the demographics, causes, characteristics, and outcomes of zygomatic fractures managed at several European departments of oral and maxillofacial surgery. Materials and methods: This study is based on a multicenter systematic database that allowed the recording of all patients with ZMC fractures between 1 January 2013 and 31 December 2017. The following data were recorded: gender, age, personal medical history, etiology, side of zygomatic fracture, classification of ZMC fracture, associated maxillofacial fractures, symptoms at diagnosis, type of performed treatment, and sequelae/complications. Results: A total of 1406 patients (1172 males, 234 females) were included in the study. Statistically significant correlations were found between assault-related ZMC fractures and the A3 class (p  lt  .0000005) and between Infraorbital Nerve (ION) anesthesia and B class (p  lt  .00000005). Conclusion: The most frequent cause of ZMC fractures was assault, followed by falls. The most frequently involved decade of age was between 20 and 29 years. The decision and type of surgical treatment of ZMC fractures depends on several issues that need to be considered on a case by case basis.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Journal of Cranio-Maxillofacial Surgery",
title = "The 'European zygomatic fracture' research project: The epidemiological results from a multicenter European collaboration",
volume = "47",
number = "4",
pages = "616-621",
doi = "10.1016/j.jcms.2019.01.026"
}

Brucoli, M., Boffano, P., Broccardo, E., Benech, A., Corre, P., Bertin, H., Pechalova, P., Pavlov, N., Petrov, P., Tamme, T., Kopchak, A., Hresko, A., Shuminsky, E., Dediol, E., Tarle, M., Konstantinović, V., Petrović, M., Holmes, S., Karagozoglu, H. K.,& Forouzanfar, T.. (2019). The 'European zygomatic fracture' research project: The epidemiological results from a multicenter European collaboration. in Journal of Cranio-Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 47(4), 616-621.
https://doi.org/10.1016/j.jcms.2019.01.026

Brucoli M, Boffano P, Broccardo E, Benech A, Corre P, Bertin H, Pechalova P, Pavlov N, Petrov P, Tamme T, Kopchak A, Hresko A, Shuminsky E, Dediol E, Tarle M, Konstantinović V, Petrović M, Holmes S, Karagozoglu HK, Forouzanfar T. The 'European zygomatic fracture' research project: The epidemiological results from a multicenter European collaboration. in Journal of Cranio-Maxillofacial Surgery. 2019;47(4):616-621.
doi:10.1016/j.jcms.2019.01.026 .

Brucoli, Matteo, Boffano, Paolo, Broccardo, Emanuele, Benech, Arnaldo, Corre, Pierre, Bertin, Helios, Pechalova, Petia, Pavlov, Nikolai, Petrov, Petko, Tamme, Tiia, Kopchak, Andrey, Hresko, Andrii, Shuminsky, Eugen, Dediol, Emil, Tarle, Marko, Konstantinović, Vitomir, Petrović, Milan, Holmes, Simon, Karagozoglu, Hakki K., Forouzanfar, Tymour, "The 'European zygomatic fracture' research project: The epidemiological results from a multicenter European collaboration" in Journal of Cranio-Maxillofacial Surgery, 47, no. 4 (2019):616-621,
https://doi.org/10.1016/j.jcms.2019.01.026 . .

TY  - JOUR
AU  - Ruslin, Muhammad
AU  - Brucoli, Matteo
AU  - Boffano, Paolo
AU  - Benech, Arnaldo
AU  - Dediol, Emil
AU  - Uglesić, Vedran
AU  - Kovacić, Ziga
AU  - Vesnaver, Ales
AU  - Konstantinović, Vitomir
AU  - Petrović, Milan
AU  - Stephens, Jonny
AU  - Kanzaria, Amar
AU  - Bhatti, Nabeel
AU  - Holmes, Simon
AU  - Pechalova, Petia
AU  - Bakardjiev, Angel G.
AU  - Malanchuk, Vladislav A.
AU  - Kopchak, Andrey
AU  - Galteland, Pal
AU  - Mjoen, Even
AU  - Skjelbred, Per
AU  - Bertin, Helios
AU  - Cone, Pierre
AU  - Loes, Sigbjorn
AU  - Lekven, Njal
AU  - Laverick, Sean
AU  - Gordon, Peter
AU  - Tamme, Tiia
AU  - Akermann, Stephanie
AU  - Karagozoglu, Hakki K.
AU  - Kommers, Sofie C.
AU  - de Visscher, Jan G.
AU  - Forouzanfar, Tymour
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2387
AB  - Objectives. The purpose of this European multicenter prospective study was to obtain more precise information about the demographic characteristics and etiologic/epidemiologic patterns of motor vehicle accidents (MVA)-related maxillofacial fractures. Study Design. Of the 3260 patients with maxillofacial fractures admitted within the study period, 326 traumas were caused by MVAs with a male/female ratio of 2.2:1. Results. The maximum incidence was found in Zagreb (Croatia) (18%) and the minimum in Bergen (Norway) (0%). The most frequent mechanisms were car accidents, with 177 cases, followed by motorcycle accidents. The most frequently observed fracture involved the mandible, with 199 fractures, followed by maxillo-zygomatic-orbital (MZO) fractures. Conclusions. In all the 3 groups (car, motorcycle, and pedestrian), mandibular and MZO fractures were the 2 most frequently observed fractures, with some variations. The importance of analyzing MVA-related facial injuries and their features and characteristics should be stressed.
PB  - Elsevier Science Inc, New York
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
T1  - Motor vehicle accidents-related maxillofacial injuries: a multicentre and prospective study
VL  - 128
IS  - 3
SP  - 199
EP  - 204
DO  - 10.1016/j.oooo.2018.12.009
ER  - 

@article{
author = "Ruslin, Muhammad and Brucoli, Matteo and Boffano, Paolo and Benech, Arnaldo and Dediol, Emil and Uglesić, Vedran and Kovacić, Ziga and Vesnaver, Ales and Konstantinović, Vitomir and Petrović, Milan and Stephens, Jonny and Kanzaria, Amar and Bhatti, Nabeel and Holmes, Simon and Pechalova, Petia and Bakardjiev, Angel G. and Malanchuk, Vladislav A. and Kopchak, Andrey and Galteland, Pal and Mjoen, Even and Skjelbred, Per and Bertin, Helios and Cone, Pierre and Loes, Sigbjorn and Lekven, Njal and Laverick, Sean and Gordon, Peter and Tamme, Tiia and Akermann, Stephanie and Karagozoglu, Hakki K. and Kommers, Sofie C. and de Visscher, Jan G. and Forouzanfar, Tymour",
year = "2019",
abstract = "Objectives. The purpose of this European multicenter prospective study was to obtain more precise information about the demographic characteristics and etiologic/epidemiologic patterns of motor vehicle accidents (MVA)-related maxillofacial fractures. Study Design. Of the 3260 patients with maxillofacial fractures admitted within the study period, 326 traumas were caused by MVAs with a male/female ratio of 2.2:1. Results. The maximum incidence was found in Zagreb (Croatia) (18%) and the minimum in Bergen (Norway) (0%). The most frequent mechanisms were car accidents, with 177 cases, followed by motorcycle accidents. The most frequently observed fracture involved the mandible, with 199 fractures, followed by maxillo-zygomatic-orbital (MZO) fractures. Conclusions. In all the 3 groups (car, motorcycle, and pedestrian), mandibular and MZO fractures were the 2 most frequently observed fractures, with some variations. The importance of analyzing MVA-related facial injuries and their features and characteristics should be stressed.",
publisher = "Elsevier Science Inc, New York",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology",
title = "Motor vehicle accidents-related maxillofacial injuries: a multicentre and prospective study",
volume = "128",
number = "3",
pages = "199-204",
doi = "10.1016/j.oooo.2018.12.009"
}

Ruslin, M., Brucoli, M., Boffano, P., Benech, A., Dediol, E., Uglesić, V., Kovacić, Z., Vesnaver, A., Konstantinović, V., Petrović, M., Stephens, J., Kanzaria, A., Bhatti, N., Holmes, S., Pechalova, P., Bakardjiev, A. G., Malanchuk, V. A., Kopchak, A., Galteland, P., Mjoen, E., Skjelbred, P., Bertin, H., Cone, P., Loes, S., Lekven, N., Laverick, S., Gordon, P., Tamme, T., Akermann, S., Karagozoglu, H. K., Kommers, S. C., de Visscher, J. G.,& Forouzanfar, T.. (2019). Motor vehicle accidents-related maxillofacial injuries: a multicentre and prospective study. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Elsevier Science Inc, New York., 128(3), 199-204.
https://doi.org/10.1016/j.oooo.2018.12.009

Ruslin M, Brucoli M, Boffano P, Benech A, Dediol E, Uglesić V, Kovacić Z, Vesnaver A, Konstantinović V, Petrović M, Stephens J, Kanzaria A, Bhatti N, Holmes S, Pechalova P, Bakardjiev AG, Malanchuk VA, Kopchak A, Galteland P, Mjoen E, Skjelbred P, Bertin H, Cone P, Loes S, Lekven N, Laverick S, Gordon P, Tamme T, Akermann S, Karagozoglu HK, Kommers SC, de Visscher JG, Forouzanfar T. Motor vehicle accidents-related maxillofacial injuries: a multicentre and prospective study. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2019;128(3):199-204.
doi:10.1016/j.oooo.2018.12.009 .

Ruslin, Muhammad, Brucoli, Matteo, Boffano, Paolo, Benech, Arnaldo, Dediol, Emil, Uglesić, Vedran, Kovacić, Ziga, Vesnaver, Ales, Konstantinović, Vitomir, Petrović, Milan, Stephens, Jonny, Kanzaria, Amar, Bhatti, Nabeel, Holmes, Simon, Pechalova, Petia, Bakardjiev, Angel G., Malanchuk, Vladislav A., Kopchak, Andrey, Galteland, Pal, Mjoen, Even, Skjelbred, Per, Bertin, Helios, Cone, Pierre, Loes, Sigbjorn, Lekven, Njal, Laverick, Sean, Gordon, Peter, Tamme, Tiia, Akermann, Stephanie, Karagozoglu, Hakki K., Kommers, Sofie C., de Visscher, Jan G., Forouzanfar, Tymour, "Motor vehicle accidents-related maxillofacial injuries: a multicentre and prospective study" in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 128, no. 3 (2019):199-204,
https://doi.org/10.1016/j.oooo.2018.12.009 . .

TY  - JOUR
AU  - Lazarević, Miloš
AU  - Milošević, Maja
AU  - Trišić, Dijana
AU  - Toljić, Boško
AU  - Simonović, Jelena
AU  - Nikolić, Nadja
AU  - Miković, Nikola
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2271
AB  - Purpose: Recent evidence suggests that small subpopulations of stem-like cells are accountable for tumour initiation, progression and metastasis. Until now, studies were focused exclusively on the characterization of these cell populations within the tumour itself, while tumour margins were neglected, although it is known that the histological and molecular status of tumour margins may play a significant role in the course of the disease. Therefore, the aims of the study were to isolate cells from oral squamous cell carcinomas and their respective margins, to characterize these cells using specific markers, to assess their self-renewal potential and determine their chemoresistance. Methods: Cell cultures were obtained from 12 tissue specimens (6 tumours and 6 margins). Total RNA was extracted and gene expression analysis was done by real-time PCR (RTPCR). Flow cytometry, immunocytometry, sphere formation and MTT assays were also applied. Results: With minor differences, cells originating from both tumours and tumour margins showed the presence of stem cell markers CD133, Nanog, Sox2, CD44, and Oct4, had the capacity to form spheroids and showed chemoresistance. Conclusions: Subpopulations of margin cells appeared to have sternness properties which might raise the question of re-evaluation of optimal surgical management.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma
VL  - 23
IS  - 6
SP  - 1686
EP  - 1692
UR  - https://hdl.handle.net/21.15107/rcub_smile_2271
ER  - 

@article{
author = "Lazarević, Miloš and Milošević, Maja and Trišić, Dijana and Toljić, Boško and Simonović, Jelena and Nikolić, Nadja and Miković, Nikola and Jelovac, Drago and Petrović, Milan and Vukadinović, Miroslav and Milašin, Jelena",
year = "2018",
abstract = "Purpose: Recent evidence suggests that small subpopulations of stem-like cells are accountable for tumour initiation, progression and metastasis. Until now, studies were focused exclusively on the characterization of these cell populations within the tumour itself, while tumour margins were neglected, although it is known that the histological and molecular status of tumour margins may play a significant role in the course of the disease. Therefore, the aims of the study were to isolate cells from oral squamous cell carcinomas and their respective margins, to characterize these cells using specific markers, to assess their self-renewal potential and determine their chemoresistance. Methods: Cell cultures were obtained from 12 tissue specimens (6 tumours and 6 margins). Total RNA was extracted and gene expression analysis was done by real-time PCR (RTPCR). Flow cytometry, immunocytometry, sphere formation and MTT assays were also applied. Results: With minor differences, cells originating from both tumours and tumour margins showed the presence of stem cell markers CD133, Nanog, Sox2, CD44, and Oct4, had the capacity to form spheroids and showed chemoresistance. Conclusions: Subpopulations of margin cells appeared to have sternness properties which might raise the question of re-evaluation of optimal surgical management.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma",
volume = "23",
number = "6",
pages = "1686-1692",
url = "https://hdl.handle.net/21.15107/rcub_smile_2271"
}

Lazarević, M., Milošević, M., Trišić, D., Toljić, B., Simonović, J., Nikolić, N., Miković, N., Jelovac, D., Petrović, M., Vukadinović, M.,& Milašin, J.. (2018). Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 23(6), 1686-1692.
https://hdl.handle.net/21.15107/rcub_smile_2271

Lazarević M, Milošević M, Trišić D, Toljić B, Simonović J, Nikolić N, Miković N, Jelovac D, Petrović M, Vukadinović M, Milašin J. Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma. in Journal of BUON. 2018;23(6):1686-1692.
https://hdl.handle.net/21.15107/rcub_smile_2271 .

Lazarević, Miloš, Milošević, Maja, Trišić, Dijana, Toljić, Boško, Simonović, Jelena, Nikolić, Nadja, Miković, Nikola, Jelovac, Drago, Petrović, Milan, Vukadinović, Miroslav, Milašin, Jelena, "Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma" in Journal of BUON, 23, no. 6 (2018):1686-1692,
https://hdl.handle.net/21.15107/rcub_smile_2271 .

TY  - JOUR
AU  - Milošević, Maja
AU  - Lazarević, Miloš
AU  - Toljić, Boško
AU  - Simonović, Jelena
AU  - Trišić, Dijana
AU  - Nikolić, Nadja
AU  - Petrović, Milan
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2279
AB  - BackgroundUnderstanding the pathogenesis of basal cell carcinoma (BCC) and identifying the cells responsible for propagation and recurrence are crucial for the development of new treatment strategies. The aim of this study was to characterize the cells isolated from BCC and its margin. MethodsPrimary cultures were established from 10 BCCs, their respective close resection margins (3mm) and 10 control tissues. Stem cell markers analysis was carried out by real-time PCR and/or flow cytometry. Spheroid formation and MTT assays were also performed. ResultsReal-time PCR showed a higher expression of embryonic (Oct4, Sox2 and Nanog) and mesenchymal (CD44 and CD73) stem cell markers in tumors compared to margins and controls (P lt 0.05). Bmi-1 and GPR49 were also upregulated in tumors in comparison with margins. Both tumor and margin cells, but not normal, had the capacity to form spheroids. During passages, the number of spheres increased, while the diameter decreased. Tumor cells showed higher chemo-resistance compared to margin and control cells. ConclusionsBasal cell carcinomas expressed stem cell markers, pointing to the existence of a cancer cell side population with stemness characteristics. Margin also appeared to harbour a small number of cancer-initiating cells.
PB  - Wiley, Hoboken
T2  - Experimental Dermatology
T1  - Characterization of stem-like cancer cells in basal cell carcinoma and its surgical margins
VL  - 27
IS  - 10
SP  - 1160
EP  - 1165
DO  - 10.1111/exd.13755
ER  - 

@article{
author = "Milošević, Maja and Lazarević, Miloš and Toljić, Boško and Simonović, Jelena and Trišić, Dijana and Nikolić, Nadja and Petrović, Milan and Milašin, Jelena",
year = "2018",
abstract = "BackgroundUnderstanding the pathogenesis of basal cell carcinoma (BCC) and identifying the cells responsible for propagation and recurrence are crucial for the development of new treatment strategies. The aim of this study was to characterize the cells isolated from BCC and its margin. MethodsPrimary cultures were established from 10 BCCs, their respective close resection margins (3mm) and 10 control tissues. Stem cell markers analysis was carried out by real-time PCR and/or flow cytometry. Spheroid formation and MTT assays were also performed. ResultsReal-time PCR showed a higher expression of embryonic (Oct4, Sox2 and Nanog) and mesenchymal (CD44 and CD73) stem cell markers in tumors compared to margins and controls (P lt 0.05). Bmi-1 and GPR49 were also upregulated in tumors in comparison with margins. Both tumor and margin cells, but not normal, had the capacity to form spheroids. During passages, the number of spheres increased, while the diameter decreased. Tumor cells showed higher chemo-resistance compared to margin and control cells. ConclusionsBasal cell carcinomas expressed stem cell markers, pointing to the existence of a cancer cell side population with stemness characteristics. Margin also appeared to harbour a small number of cancer-initiating cells.",
publisher = "Wiley, Hoboken",
journal = "Experimental Dermatology",
title = "Characterization of stem-like cancer cells in basal cell carcinoma and its surgical margins",
volume = "27",
number = "10",
pages = "1160-1165",
doi = "10.1111/exd.13755"
}

Milošević, M., Lazarević, M., Toljić, B., Simonović, J., Trišić, D., Nikolić, N., Petrović, M.,& Milašin, J.. (2018). Characterization of stem-like cancer cells in basal cell carcinoma and its surgical margins. in Experimental Dermatology
Wiley, Hoboken., 27(10), 1160-1165.
https://doi.org/10.1111/exd.13755

Milošević M, Lazarević M, Toljić B, Simonović J, Trišić D, Nikolić N, Petrović M, Milašin J. Characterization of stem-like cancer cells in basal cell carcinoma and its surgical margins. in Experimental Dermatology. 2018;27(10):1160-1165.
doi:10.1111/exd.13755 .

Milošević, Maja, Lazarević, Miloš, Toljić, Boško, Simonović, Jelena, Trišić, Dijana, Nikolić, Nadja, Petrović, Milan, Milašin, Jelena, "Characterization of stem-like cancer cells in basal cell carcinoma and its surgical margins" in Experimental Dermatology, 27, no. 10 (2018):1160-1165,
https://doi.org/10.1111/exd.13755 . .

TY  - JOUR
AU  - Jokanović, Vukoman
AU  - Čolović, Božana
AU  - Marković, Dejan
AU  - Petrović, Milan
AU  - Soldatović, Ivan
AU  - Antonijević, Đorđe
AU  - Milosavljević, Petar
AU  - Sjerobabin, Nikola
AU  - Sopta, Jelena
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2187
AB  - This study examined the potential of a new porous calcium hydroxyapatite scaffold covered with poly (lactide-co-glycolide) (PLGA) as a bone substitute, identifying its advantages over Geistlich Bio-Oss (R), considered the gold standard, in in vivo biofunctionality investigations. Structural and morphological properties of the new scaffold were analyzed by scanning electron and atomic force microscopy. The biofunctionality assays were performed on New Zealand white rabbits using new scaffold for filling full-thickness defects of critical size. The evaluated parameters were: the presence of macrophages, giant cells, monoocytes, plasma cells, granulocytes, neo-angiogenesis, fibroplasia, and the percentage of mineralization. Parallel biofunctionality assays were performed using Geistlich Bio-Oss (R). The appearance of bone defects 12 weeks after the new scaffold implantation showed the presence of a small number of typical immune response cells. Furthermore, significantly reduced number of capillary buds, low intensity of fibroplasia and high degree of mineralization in a lamellar pattern indicated that the inflammation process has been almost completely overcome and that the new bone formed was in the final phase of remodeling. All biofunctionality assays proved the new scaffold's suitability as a bone substitute for applications in maxillofacial surgery. It showed numerous biological advantages over Geistlich Bio-Oss (R) which was reflected mainly as a lower number of giant cells surrounding implanted material and higher degree of mineralization in new formed bone.
PB  - Walter De Gruyter Gmbh, Berlin
T2  - Biomedical Engineering - Biomedizinische Technik
T1  - Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation
VL  - 62
IS  - 3
SP  - 295
EP  - 306
DO  - 10.1515/bmt-2015-0164
ER  - 

@article{
author = "Jokanović, Vukoman and Čolović, Božana and Marković, Dejan and Petrović, Milan and Soldatović, Ivan and Antonijević, Đorđe and Milosavljević, Petar and Sjerobabin, Nikola and Sopta, Jelena",
year = "2017",
abstract = "This study examined the potential of a new porous calcium hydroxyapatite scaffold covered with poly (lactide-co-glycolide) (PLGA) as a bone substitute, identifying its advantages over Geistlich Bio-Oss (R), considered the gold standard, in in vivo biofunctionality investigations. Structural and morphological properties of the new scaffold were analyzed by scanning electron and atomic force microscopy. The biofunctionality assays were performed on New Zealand white rabbits using new scaffold for filling full-thickness defects of critical size. The evaluated parameters were: the presence of macrophages, giant cells, monoocytes, plasma cells, granulocytes, neo-angiogenesis, fibroplasia, and the percentage of mineralization. Parallel biofunctionality assays were performed using Geistlich Bio-Oss (R). The appearance of bone defects 12 weeks after the new scaffold implantation showed the presence of a small number of typical immune response cells. Furthermore, significantly reduced number of capillary buds, low intensity of fibroplasia and high degree of mineralization in a lamellar pattern indicated that the inflammation process has been almost completely overcome and that the new bone formed was in the final phase of remodeling. All biofunctionality assays proved the new scaffold's suitability as a bone substitute for applications in maxillofacial surgery. It showed numerous biological advantages over Geistlich Bio-Oss (R) which was reflected mainly as a lower number of giant cells surrounding implanted material and higher degree of mineralization in new formed bone.",
publisher = "Walter De Gruyter Gmbh, Berlin",
journal = "Biomedical Engineering - Biomedizinische Technik",
title = "Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation",
volume = "62",
number = "3",
pages = "295-306",
doi = "10.1515/bmt-2015-0164"
}

Jokanović, V., Čolović, B., Marković, D., Petrović, M., Soldatović, I., Antonijević, Đ., Milosavljević, P., Sjerobabin, N.,& Sopta, J.. (2017). Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation. in Biomedical Engineering - Biomedizinische Technik
Walter De Gruyter Gmbh, Berlin., 62(3), 295-306.
https://doi.org/10.1515/bmt-2015-0164

Jokanović V, Čolović B, Marković D, Petrović M, Soldatović I, Antonijević Đ, Milosavljević P, Sjerobabin N, Sopta J. Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation. in Biomedical Engineering - Biomedizinische Technik. 2017;62(3):295-306.
doi:10.1515/bmt-2015-0164 .

Jokanović, Vukoman, Čolović, Božana, Marković, Dejan, Petrović, Milan, Soldatović, Ivan, Antonijević, Đorđe, Milosavljević, Petar, Sjerobabin, Nikola, Sopta, Jelena, "Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation" in Biomedical Engineering - Biomedizinische Technik, 62, no. 3 (2017):295-306,
https://doi.org/10.1515/bmt-2015-0164 . .

TY  - JOUR
AU  - Jokanović, Vukoman
AU  - Čolović, Božana
AU  - Marković, Dejan
AU  - Petrović, Milan
AU  - Jokanović, Milan
AU  - Milosavljević, Petar
AU  - Sopta, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2168
AB  - A synthetic bone substitute based on calcium hydroxyapatite (CHA) and poly(lactic-co-glycolic) acid (PLGA), described in this paper, was synthesized to fulfill specific requirements like biodegradability, satisfying mechanical properties, optimal porosity and nanotopology, osteoinductive and osteoconductive properties, and so forth. Structural and morphological properties of the new scaffold were analyzed by micro computed tomography and scanning electron microscopy, while its physicochemical properties were investigated by X-ray diffraction and infrared spectroscopy. In vivo biological investigations of the synthesized scaffold were conducted over the cutaneous irritation and biofunctionality assays on rabbits and the test of acute systemic toxicity on mice. The results showed that the scaffold is not irritant and that it does not exhibit any symptoms of acute toxicity. Biofunctionality assays which include evaluation of the presence of various cells of immune response, the presence of neoangiogenesis, percentage of mineralization of newly formed bone, and fibroplasia in the tissue indicated that the new scaffold is suitable for the application in maxillofacial and dental surgery as a bone substitute. Also, it showed significant advantages over commercial product Geistlich Bio-Oss(R) from the aspect of some parameters of immunological response.
PB  - Hindawi Ltd, London
T2  - Journal of Nanomaterials
T1  - In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA
VL  - 2016
DO  - 10.1155/2016/3948768
ER  - 

@article{
author = "Jokanović, Vukoman and Čolović, Božana and Marković, Dejan and Petrović, Milan and Jokanović, Milan and Milosavljević, Petar and Sopta, Jelena",
year = "2016",
abstract = "A synthetic bone substitute based on calcium hydroxyapatite (CHA) and poly(lactic-co-glycolic) acid (PLGA), described in this paper, was synthesized to fulfill specific requirements like biodegradability, satisfying mechanical properties, optimal porosity and nanotopology, osteoinductive and osteoconductive properties, and so forth. Structural and morphological properties of the new scaffold were analyzed by micro computed tomography and scanning electron microscopy, while its physicochemical properties were investigated by X-ray diffraction and infrared spectroscopy. In vivo biological investigations of the synthesized scaffold were conducted over the cutaneous irritation and biofunctionality assays on rabbits and the test of acute systemic toxicity on mice. The results showed that the scaffold is not irritant and that it does not exhibit any symptoms of acute toxicity. Biofunctionality assays which include evaluation of the presence of various cells of immune response, the presence of neoangiogenesis, percentage of mineralization of newly formed bone, and fibroplasia in the tissue indicated that the new scaffold is suitable for the application in maxillofacial and dental surgery as a bone substitute. Also, it showed significant advantages over commercial product Geistlich Bio-Oss(R) from the aspect of some parameters of immunological response.",
publisher = "Hindawi Ltd, London",
journal = "Journal of Nanomaterials",
title = "In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA",
volume = "2016",
doi = "10.1155/2016/3948768"
}

Jokanović, V., Čolović, B., Marković, D., Petrović, M., Jokanović, M., Milosavljević, P.,& Sopta, J.. (2016). In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA. in Journal of Nanomaterials
Hindawi Ltd, London., 2016.
https://doi.org/10.1155/2016/3948768

Jokanović V, Čolović B, Marković D, Petrović M, Jokanović M, Milosavljević P, Sopta J. In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA. in Journal of Nanomaterials. 2016;2016.
doi:10.1155/2016/3948768 .

Jokanović, Vukoman, Čolović, Božana, Marković, Dejan, Petrović, Milan, Jokanović, Milan, Milosavljević, Petar, Sopta, Jelena, "In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA" in Journal of Nanomaterials, 2016 (2016),
https://doi.org/10.1155/2016/3948768 . .

TY  - JOUR
AU  - Sjerobabin, Nikola
AU  - Čolović, Božana
AU  - Petrović, Milan
AU  - Marković, Dejan
AU  - Živković, Slavoljub
AU  - Jokanović, Vukoman
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2162
AB  - Introduction: Biodegradable porous scaffolds are found to be very promising bone substitutes, acting as a temporary physical support to guide new tissue regeneration, until the entire scaffold is totally degraded and replaced by the new tissue. Objective The aim of this study was to investigate cytotoxicity of a synthesized calcium hydroxyapatite-based scaffold, named ALBO-OS, with high porosity and optimal topology. Methods The ALBO-OS scaffold was synthesized by the method of polymer foam template. The analysis of pore geometry and scaffold walls' topography was made by scanning electron microscope (SEM). The biological investigations assumed the examinations of ALBO-OS cytotoxicity to mouse L929 fibroblasts, using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidefor (MTT) and lactate dehydrogenase (LDH) tests and inverse phase microscopy. Results The SEM analysis showed high porosity with fair pore distribution and interesting morphology from the biological standpoint. The biological investigations showed that the material is not cytotoxic to L929 cells. Comparison of ALBO-OS with Bio-Oss, as the global gold standard as a bone substitute, showed similar results in MTT test, while LDH test showed significantly higher rate of cell multiplication with ALBO-OS. Conclusion The scaffold design from the aspect of pore size, distribution, and topology seems to be very convenient for cell adhesion and occupation, which makes it a promising material as a bone substitute. The results of biological assays proved that ALBO-OS is not cytotoxic for L929 fibroblasts. In comparison with Bio-Oss, similar or even better results were obtained.
AB  - Uvod: Porozni biodegradabilni nosači su se pokazali kao dobri zamenici kosti jer deluju kao privremena fizička potpora za usmerenu regeneraciju tkiva dok se čitav nosač potpuno ne razgradi i zameni novim tkivom. Cilj rada Cilj ovog rada je bio da se ispita citotoksičnost nosača tkiva na bazi kalcijum-hidroksiapatita, visoke poroznosti i optimalne topologije, nazvanog ALBO-OS. Metode rada Zamenik kosti ALBO-OS je sintetisan metodom matrice napravljene od polimerne pene. Geometrija pora i zidova nosača analizirane su pomoću skenirajuće elektronske mikroskopije (SEM). Biološka istraživanja izvedena su ispitivanjem citotoksičnosti ALBO-OS-a na mišjim fibroblastima L929 pomoću MTT i LDH testova i fazno kontrastne mikroskopije. Rezultati SEM analiza je pokazala veliku i ravnomernu poroznost i zanimljivu morfologiju sa biološkog stanovišta. Biološka istraživanja pokazala su da materijal nije citotoksičan. Poređenjem materijala ALBO-OS i Bio-Oss, koji je, globalno, zlatni standard među zamenicima kosti, dobijeni su slični rezultati na MTT testu, dok su rezulati LDH testa pokazali značajno veći broj ćelijskih deoba u kontaktu sa ALBO-OS-om. Zaključak Dizajn nosača sa stanovišta raspodele veličine pora i topologije je veoma pogodan za adheziju i naseljavanje ćelija, zbog čega ima veliki potencijal kao zamenik kosti. Rezultati bioloških testova su pokazali da ALBO-OS nije citotoksičan za L929 fibroblaste. U poređenju sa materijalom Bio-Oss, dobijeni su slični ili bolji rezultati.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design
T1  - Ispitivanje citotoksičnosti nosača na bazi hidroksiapatita s unapređenim strukturnim dizajnom
VL  - 144
IS  - 5-6
SP  - 280
EP  - 287
DO  - 10.2298/SARH1606280S
ER  - 

@article{
author = "Sjerobabin, Nikola and Čolović, Božana and Petrović, Milan and Marković, Dejan and Živković, Slavoljub and Jokanović, Vukoman",
year = "2016",
abstract = "Introduction: Biodegradable porous scaffolds are found to be very promising bone substitutes, acting as a temporary physical support to guide new tissue regeneration, until the entire scaffold is totally degraded and replaced by the new tissue. Objective The aim of this study was to investigate cytotoxicity of a synthesized calcium hydroxyapatite-based scaffold, named ALBO-OS, with high porosity and optimal topology. Methods The ALBO-OS scaffold was synthesized by the method of polymer foam template. The analysis of pore geometry and scaffold walls' topography was made by scanning electron microscope (SEM). The biological investigations assumed the examinations of ALBO-OS cytotoxicity to mouse L929 fibroblasts, using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidefor (MTT) and lactate dehydrogenase (LDH) tests and inverse phase microscopy. Results The SEM analysis showed high porosity with fair pore distribution and interesting morphology from the biological standpoint. The biological investigations showed that the material is not cytotoxic to L929 cells. Comparison of ALBO-OS with Bio-Oss, as the global gold standard as a bone substitute, showed similar results in MTT test, while LDH test showed significantly higher rate of cell multiplication with ALBO-OS. Conclusion The scaffold design from the aspect of pore size, distribution, and topology seems to be very convenient for cell adhesion and occupation, which makes it a promising material as a bone substitute. The results of biological assays proved that ALBO-OS is not cytotoxic for L929 fibroblasts. In comparison with Bio-Oss, similar or even better results were obtained., Uvod: Porozni biodegradabilni nosači su se pokazali kao dobri zamenici kosti jer deluju kao privremena fizička potpora za usmerenu regeneraciju tkiva dok se čitav nosač potpuno ne razgradi i zameni novim tkivom. Cilj rada Cilj ovog rada je bio da se ispita citotoksičnost nosača tkiva na bazi kalcijum-hidroksiapatita, visoke poroznosti i optimalne topologije, nazvanog ALBO-OS. Metode rada Zamenik kosti ALBO-OS je sintetisan metodom matrice napravljene od polimerne pene. Geometrija pora i zidova nosača analizirane su pomoću skenirajuće elektronske mikroskopije (SEM). Biološka istraživanja izvedena su ispitivanjem citotoksičnosti ALBO-OS-a na mišjim fibroblastima L929 pomoću MTT i LDH testova i fazno kontrastne mikroskopije. Rezultati SEM analiza je pokazala veliku i ravnomernu poroznost i zanimljivu morfologiju sa biološkog stanovišta. Biološka istraživanja pokazala su da materijal nije citotoksičan. Poređenjem materijala ALBO-OS i Bio-Oss, koji je, globalno, zlatni standard među zamenicima kosti, dobijeni su slični rezultati na MTT testu, dok su rezulati LDH testa pokazali značajno veći broj ćelijskih deoba u kontaktu sa ALBO-OS-om. Zaključak Dizajn nosača sa stanovišta raspodele veličine pora i topologije je veoma pogodan za adheziju i naseljavanje ćelija, zbog čega ima veliki potencijal kao zamenik kosti. Rezultati bioloških testova su pokazali da ALBO-OS nije citotoksičan za L929 fibroblaste. U poređenju sa materijalom Bio-Oss, dobijeni su slični ili bolji rezultati.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design, Ispitivanje citotoksičnosti nosača na bazi hidroksiapatita s unapređenim strukturnim dizajnom",
volume = "144",
number = "5-6",
pages = "280-287",
doi = "10.2298/SARH1606280S"
}

Sjerobabin, N., Čolović, B., Petrović, M., Marković, D., Živković, S.,& Jokanović, V.. (2016). Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 144(5-6), 280-287.
https://doi.org/10.2298/SARH1606280S

Sjerobabin N, Čolović B, Petrović M, Marković D, Živković S, Jokanović V. Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design. in Srpski arhiv za celokupno lekarstvo. 2016;144(5-6):280-287.
doi:10.2298/SARH1606280S .

Sjerobabin, Nikola, Čolović, Božana, Petrović, Milan, Marković, Dejan, Živković, Slavoljub, Jokanović, Vukoman, "Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design" in Srpski arhiv za celokupno lekarstvo, 144, no. 5-6 (2016):280-287,
https://doi.org/10.2298/SARH1606280S . .

TY  - JOUR
AU  - Petrović, Nina
AU  - Davidović, Radoslav
AU  - Jovanović-Cupić, Snezana
AU  - Krajnović, Milena
AU  - Lukić, Silvana
AU  - Petrović, Milan
AU  - Roganović, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2120
AB  - Breast cancer (BC) is a heterogeneous group of diseases that still represents a major cause of death in the female population. MicroRNAs (miRNAs, miRs), such as miR-221 and miR-222, have been shown to be involved in BC pathology by acting via its target genes such as tissue inhibitor of metalloproteinase 3 (TIMP3). The main goals of this study were to find differences in miR-221/222 levels of expression in BC groups based on invasiveness, and to investigate the association with estrogen receptor (ER), TIMP3 messenger RNA (mRNA) levels, and clinicopathological characteristics of patients and tumors. In this study, we measured levels of miR-221/222 in 63 breast tissue samples by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using TaqMan(A (R)) technology and immunohistochemistry. miR-221/222 levels varied significantly across groups based on invasiveness (P  lt  0.001). In in situ tumors, miR-221 and miR-222 were negatively associated with ER (P = 0.001, r = -0.714, and P = 0.013, r = -0.585, respectively). In invasive breast carcinomas associated with non-invasive tumors, miR-222 was inversely associated with ER (P = 0.039, r = -0.620). Pure invasive BCs showed a positive correlation of miR-221 and miR-222 with TIMP3 mRNA levels (P = 0.008, r = 0.508, and P = 0.010, r = 0.497, respectively). An increase in miR-221/222 might be an important event for in situ carcinoma formation, and miR-221/222 may be important molecules that highlight potential differences between invasive breast carcinomas associated with non-invasive and pure invasive BCs.
PB  - Adis Int Ltd, Northcote
T2  - Molecular Diagnosis & Therapy
T1  - Changes in miR-221/222 Levels in Invasive and In Situ Carcinomas of the Breast: Differences in Association with Estrogen Receptor and TIMP3 Expression Levels
VL  - 20
IS  - 6
SP  - 603
EP  - 615
DO  - 10.1007/s40291-016-0230-3
ER  - 

@article{
author = "Petrović, Nina and Davidović, Radoslav and Jovanović-Cupić, Snezana and Krajnović, Milena and Lukić, Silvana and Petrović, Milan and Roganović, Jelena",
year = "2016",
abstract = "Breast cancer (BC) is a heterogeneous group of diseases that still represents a major cause of death in the female population. MicroRNAs (miRNAs, miRs), such as miR-221 and miR-222, have been shown to be involved in BC pathology by acting via its target genes such as tissue inhibitor of metalloproteinase 3 (TIMP3). The main goals of this study were to find differences in miR-221/222 levels of expression in BC groups based on invasiveness, and to investigate the association with estrogen receptor (ER), TIMP3 messenger RNA (mRNA) levels, and clinicopathological characteristics of patients and tumors. In this study, we measured levels of miR-221/222 in 63 breast tissue samples by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using TaqMan(A (R)) technology and immunohistochemistry. miR-221/222 levels varied significantly across groups based on invasiveness (P  lt  0.001). In in situ tumors, miR-221 and miR-222 were negatively associated with ER (P = 0.001, r = -0.714, and P = 0.013, r = -0.585, respectively). In invasive breast carcinomas associated with non-invasive tumors, miR-222 was inversely associated with ER (P = 0.039, r = -0.620). Pure invasive BCs showed a positive correlation of miR-221 and miR-222 with TIMP3 mRNA levels (P = 0.008, r = 0.508, and P = 0.010, r = 0.497, respectively). An increase in miR-221/222 might be an important event for in situ carcinoma formation, and miR-221/222 may be important molecules that highlight potential differences between invasive breast carcinomas associated with non-invasive and pure invasive BCs.",
publisher = "Adis Int Ltd, Northcote",
journal = "Molecular Diagnosis & Therapy",
title = "Changes in miR-221/222 Levels in Invasive and In Situ Carcinomas of the Breast: Differences in Association with Estrogen Receptor and TIMP3 Expression Levels",
volume = "20",
number = "6",
pages = "603-615",
doi = "10.1007/s40291-016-0230-3"
}

Petrović, N., Davidović, R., Jovanović-Cupić, S., Krajnović, M., Lukić, S., Petrović, M.,& Roganović, J.. (2016). Changes in miR-221/222 Levels in Invasive and In Situ Carcinomas of the Breast: Differences in Association with Estrogen Receptor and TIMP3 Expression Levels. in Molecular Diagnosis & Therapy
Adis Int Ltd, Northcote., 20(6), 603-615.
https://doi.org/10.1007/s40291-016-0230-3

Petrović N, Davidović R, Jovanović-Cupić S, Krajnović M, Lukić S, Petrović M, Roganović J. Changes in miR-221/222 Levels in Invasive and In Situ Carcinomas of the Breast: Differences in Association with Estrogen Receptor and TIMP3 Expression Levels. in Molecular Diagnosis & Therapy. 2016;20(6):603-615.
doi:10.1007/s40291-016-0230-3 .

Petrović, Nina, Davidović, Radoslav, Jovanović-Cupić, Snezana, Krajnović, Milena, Lukić, Silvana, Petrović, Milan, Roganović, Jelena, "Changes in miR-221/222 Levels in Invasive and In Situ Carcinomas of the Breast: Differences in Association with Estrogen Receptor and TIMP3 Expression Levels" in Molecular Diagnosis & Therapy, 20, no. 6 (2016):603-615,
https://doi.org/10.1007/s40291-016-0230-3 . .

TY  - JOUR
AU  - Miković, Nikola
AU  - Lazarević, Miloš
AU  - Tatić, Zoran
AU  - Krejović-Trivić, Sanja
AU  - Petrović, Milan
AU  - Trivić, Aleksandar
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2114
AB  - Background/Aim. Postoperative condylar position is a substantial concern in surgical correction of mandibular prognathism. Orthognathic surgery may change condylar position and this is considered a contributing factor for early skeletal relapse and the induction of temporomandibular disorders. The purpose of this study was to evaluate changes in condylar position, and to correlate angular skeletal measurements following bimaxillary surgery. Methods. On profile teleradiographs of 21 patients with mandibular angular and linear parametres, the changes in condylar position, were measured during preoperative orthodontic treatment and 6 months after the surgical treatment. Results. A statistically significant difference in values between the groups was found. The most distal point on the head of condyle point (DI) moved backward for 1.38 mm (p = 0.02), and the point of center of collum mandibulae point (DC) moved backward for 1.52 mm (p = 0.007). The amount of upward movement of the point DI was 1.62 mm (p = 0.04). Conclusion. In the patients with mandibular prognathism, the condyles tend to migrate upward and forward six months after bimaxillary surgery.
AB  - Uvod/Cilj. Postoperativna pozicija kondila je značajna za hiruršku korekciju mandibularnog prognatizma. Ortognatska hirurgija može da promeni poziciju kondila, a to može biti jedan od faktora koji doprinosi ranom skeletnom recidivu i pojavi temporomandibularnih disfunkcija. Zbog toga je cilj ove studije bio da proceni promene pozicije kondila kao i da ne korelišu promene pozicije kondila sa angularnim skeletnim promenama nakon bimaksilarne hirurgije. Metode. Na telerendgenskim snimcima 21 bolesnika sa mandibularnim prognatizmom mereni su angularni i linearni parametri koji opisuju promene u položaju kondila, pre ortodontske pripreme i šest meseci nakon hirurške korekcije. Rezultati. Ustanovljena je statistička značajnost razlika u vrednosti parametara između grupa. Tačka DI - najdistalnija tačka na glavi kondila, pomerila se unazad 1,38 mm (p = 0,02), a tačka DC - tačka koja označava centar collum mandibulae, pomerila se, takođe, unazad za 1,52 mm (p = 0,007). Vrednost pomeranja tačke DI naviše bila je 1,62 mm (p = 0,04). Zaključak. Kod bolesnika sa mandibularnim prognatizmom, kondili su težili da migriraju unapred i naviše šest meseci nakon bimaksilarne operacije.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Radiographic cephalometry analysis of condylar position after bimaxillary osteotomy in patients with mandibular prognathism
T1  - Rendgen-kefalometrijska analiza pozicije kondila nakon bimaksilarne osteotomije mandibularnog prognatizma
VL  - 73
IS  - 4
SP  - 318
EP  - 325
DO  - 10.2298/vsp141210051M
ER  - 

@article{
author = "Miković, Nikola and Lazarević, Miloš and Tatić, Zoran and Krejović-Trivić, Sanja and Petrović, Milan and Trivić, Aleksandar",
year = "2016",
abstract = "Background/Aim. Postoperative condylar position is a substantial concern in surgical correction of mandibular prognathism. Orthognathic surgery may change condylar position and this is considered a contributing factor for early skeletal relapse and the induction of temporomandibular disorders. The purpose of this study was to evaluate changes in condylar position, and to correlate angular skeletal measurements following bimaxillary surgery. Methods. On profile teleradiographs of 21 patients with mandibular angular and linear parametres, the changes in condylar position, were measured during preoperative orthodontic treatment and 6 months after the surgical treatment. Results. A statistically significant difference in values between the groups was found. The most distal point on the head of condyle point (DI) moved backward for 1.38 mm (p = 0.02), and the point of center of collum mandibulae point (DC) moved backward for 1.52 mm (p = 0.007). The amount of upward movement of the point DI was 1.62 mm (p = 0.04). Conclusion. In the patients with mandibular prognathism, the condyles tend to migrate upward and forward six months after bimaxillary surgery., Uvod/Cilj. Postoperativna pozicija kondila je značajna za hiruršku korekciju mandibularnog prognatizma. Ortognatska hirurgija može da promeni poziciju kondila, a to može biti jedan od faktora koji doprinosi ranom skeletnom recidivu i pojavi temporomandibularnih disfunkcija. Zbog toga je cilj ove studije bio da proceni promene pozicije kondila kao i da ne korelišu promene pozicije kondila sa angularnim skeletnim promenama nakon bimaksilarne hirurgije. Metode. Na telerendgenskim snimcima 21 bolesnika sa mandibularnim prognatizmom mereni su angularni i linearni parametri koji opisuju promene u položaju kondila, pre ortodontske pripreme i šest meseci nakon hirurške korekcije. Rezultati. Ustanovljena je statistička značajnost razlika u vrednosti parametara između grupa. Tačka DI - najdistalnija tačka na glavi kondila, pomerila se unazad 1,38 mm (p = 0,02), a tačka DC - tačka koja označava centar collum mandibulae, pomerila se, takođe, unazad za 1,52 mm (p = 0,007). Vrednost pomeranja tačke DI naviše bila je 1,62 mm (p = 0,04). Zaključak. Kod bolesnika sa mandibularnim prognatizmom, kondili su težili da migriraju unapred i naviše šest meseci nakon bimaksilarne operacije.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Radiographic cephalometry analysis of condylar position after bimaxillary osteotomy in patients with mandibular prognathism, Rendgen-kefalometrijska analiza pozicije kondila nakon bimaksilarne osteotomije mandibularnog prognatizma",
volume = "73",
number = "4",
pages = "318-325",
doi = "10.2298/vsp141210051M"
}

Miković, N., Lazarević, M., Tatić, Z., Krejović-Trivić, S., Petrović, M.,& Trivić, A.. (2016). Radiographic cephalometry analysis of condylar position after bimaxillary osteotomy in patients with mandibular prognathism. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(4), 318-325.
https://doi.org/10.2298/vsp141210051M

Miković N, Lazarević M, Tatić Z, Krejović-Trivić S, Petrović M, Trivić A. Radiographic cephalometry analysis of condylar position after bimaxillary osteotomy in patients with mandibular prognathism. in Vojnosanitetski pregled. 2016;73(4):318-325.
doi:10.2298/vsp141210051M .

Miković, Nikola, Lazarević, Miloš, Tatić, Zoran, Krejović-Trivić, Sanja, Petrović, Milan, Trivić, Aleksandar, "Radiographic cephalometry analysis of condylar position after bimaxillary osteotomy in patients with mandibular prognathism" in Vojnosanitetski pregled, 73, no. 4 (2016):318-325,
https://doi.org/10.2298/vsp141210051M . .

TY  - JOUR
AU  - Boffano, Paolo
AU  - Roccia, Fabio
AU  - Zavattero, Emanuele
AU  - Dediol, Emil
AU  - Uglesić, Vedran
AU  - Kovacić, Ziga
AU  - Vesnaver, Ales
AU  - Konstantinović, Vitomir
AU  - Petrović, Milan
AU  - Stephens, Jonny
AU  - Kanzaria, Amar
AU  - Bhatti, Nabeel
AU  - Holmes, Simon
AU  - Pechalova, Petia
AU  - Bakardjiev, Angel G.
AU  - Malanchuk, Vladislav A.
AU  - Kopchak, Andrey
AU  - Galteland, Pal
AU  - Mjoen, Even
AU  - Skjelbred, Per
AU  - Koudougou, Carine
AU  - Mouallem, Guillaume
AU  - Corre, Pierre
AU  - Loes, Sigbjorn
AU  - Lekven, Njal
AU  - Laverick, Sean
AU  - Gordon, Peter
AU  - Tamme, Tiia
AU  - Akermann, Stephanie
AU  - Karagozoglu, Hakki K.
AU  - Kommers, Sofie C.
AU  - Forouzanfar, Tymour
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2060
AB  - The purpose of this study was to analyse the demographics, causes and characteristics of maxillofacial fractures managed at several European departments of oral and maxillofacial surgery over one year. The following data were recorded: gender, age, aetiology, site of facial fractures, facial injury severity score, timing of intervention, length of hospital stay. Data for a total of 3396 patients (2655 males and 741 females) with 4155 fractures were recorded. The mean age differed from country to country, ranging between 29.9 and 43.9 years. Overall, the most frequent cause of injury was assault, which accounted for the injuries of 1309 patients; assaults and falls alternated as the most important aetiological factor in the various centres. The most frequently observed fracture involved the mandible with 1743 fractures, followed by orbital-zygomatic-maxillary (OZM) fractures. Condylar fractures were the most commonly observed mandibular fracture. The results of the EURMAT collaboration confirm the changing trend in maxillofacial trauma epidemiology in Europe, with trauma cases caused by assaults and falls now outnumbering those due to road traffic accidents. The progressive ageing of the European population, in addition to strict road and work legislation may have been responsible for this change. Men are still the most frequent victims of maxillofacial injuries.
PB  - Churchill Livingstone, Edinburgh
T2  - Journal of Cranio-Maxillofacial Surgery
T1  - European Maxillofacial Trauma (EURMAT) project: A multicentre and prospective study
VL  - 43
IS  - 1
SP  - 62
EP  - 70
DO  - 10.1016/j.jcms.2014.10.011
ER  - 

@article{
author = "Boffano, Paolo and Roccia, Fabio and Zavattero, Emanuele and Dediol, Emil and Uglesić, Vedran and Kovacić, Ziga and Vesnaver, Ales and Konstantinović, Vitomir and Petrović, Milan and Stephens, Jonny and Kanzaria, Amar and Bhatti, Nabeel and Holmes, Simon and Pechalova, Petia and Bakardjiev, Angel G. and Malanchuk, Vladislav A. and Kopchak, Andrey and Galteland, Pal and Mjoen, Even and Skjelbred, Per and Koudougou, Carine and Mouallem, Guillaume and Corre, Pierre and Loes, Sigbjorn and Lekven, Njal and Laverick, Sean and Gordon, Peter and Tamme, Tiia and Akermann, Stephanie and Karagozoglu, Hakki K. and Kommers, Sofie C. and Forouzanfar, Tymour",
year = "2015",
abstract = "The purpose of this study was to analyse the demographics, causes and characteristics of maxillofacial fractures managed at several European departments of oral and maxillofacial surgery over one year. The following data were recorded: gender, age, aetiology, site of facial fractures, facial injury severity score, timing of intervention, length of hospital stay. Data for a total of 3396 patients (2655 males and 741 females) with 4155 fractures were recorded. The mean age differed from country to country, ranging between 29.9 and 43.9 years. Overall, the most frequent cause of injury was assault, which accounted for the injuries of 1309 patients; assaults and falls alternated as the most important aetiological factor in the various centres. The most frequently observed fracture involved the mandible with 1743 fractures, followed by orbital-zygomatic-maxillary (OZM) fractures. Condylar fractures were the most commonly observed mandibular fracture. The results of the EURMAT collaboration confirm the changing trend in maxillofacial trauma epidemiology in Europe, with trauma cases caused by assaults and falls now outnumbering those due to road traffic accidents. The progressive ageing of the European population, in addition to strict road and work legislation may have been responsible for this change. Men are still the most frequent victims of maxillofacial injuries.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Journal of Cranio-Maxillofacial Surgery",
title = "European Maxillofacial Trauma (EURMAT) project: A multicentre and prospective study",
volume = "43",
number = "1",
pages = "62-70",
doi = "10.1016/j.jcms.2014.10.011"
}

Boffano, P., Roccia, F., Zavattero, E., Dediol, E., Uglesić, V., Kovacić, Z., Vesnaver, A., Konstantinović, V., Petrović, M., Stephens, J., Kanzaria, A., Bhatti, N., Holmes, S., Pechalova, P., Bakardjiev, A. G., Malanchuk, V. A., Kopchak, A., Galteland, P., Mjoen, E., Skjelbred, P., Koudougou, C., Mouallem, G., Corre, P., Loes, S., Lekven, N., Laverick, S., Gordon, P., Tamme, T., Akermann, S., Karagozoglu, H. K., Kommers, S. C.,& Forouzanfar, T.. (2015). European Maxillofacial Trauma (EURMAT) project: A multicentre and prospective study. in Journal of Cranio-Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 43(1), 62-70.
https://doi.org/10.1016/j.jcms.2014.10.011

Boffano P, Roccia F, Zavattero E, Dediol E, Uglesić V, Kovacić Z, Vesnaver A, Konstantinović V, Petrović M, Stephens J, Kanzaria A, Bhatti N, Holmes S, Pechalova P, Bakardjiev AG, Malanchuk VA, Kopchak A, Galteland P, Mjoen E, Skjelbred P, Koudougou C, Mouallem G, Corre P, Loes S, Lekven N, Laverick S, Gordon P, Tamme T, Akermann S, Karagozoglu HK, Kommers SC, Forouzanfar T. European Maxillofacial Trauma (EURMAT) project: A multicentre and prospective study. in Journal of Cranio-Maxillofacial Surgery. 2015;43(1):62-70.
doi:10.1016/j.jcms.2014.10.011 .

Boffano, Paolo, Roccia, Fabio, Zavattero, Emanuele, Dediol, Emil, Uglesić, Vedran, Kovacić, Ziga, Vesnaver, Ales, Konstantinović, Vitomir, Petrović, Milan, Stephens, Jonny, Kanzaria, Amar, Bhatti, Nabeel, Holmes, Simon, Pechalova, Petia, Bakardjiev, Angel G., Malanchuk, Vladislav A., Kopchak, Andrey, Galteland, Pal, Mjoen, Even, Skjelbred, Per, Koudougou, Carine, Mouallem, Guillaume, Corre, Pierre, Loes, Sigbjorn, Lekven, Njal, Laverick, Sean, Gordon, Peter, Tamme, Tiia, Akermann, Stephanie, Karagozoglu, Hakki K., Kommers, Sofie C., Forouzanfar, Tymour, "European Maxillofacial Trauma (EURMAT) project: A multicentre and prospective study" in Journal of Cranio-Maxillofacial Surgery, 43, no. 1 (2015):62-70,
https://doi.org/10.1016/j.jcms.2014.10.011 . .

TY  - JOUR
AU  - Boffano, Paolo
AU  - Roccia, Fabio
AU  - Zavattero, Emanuele
AU  - Dediol, Emil
AU  - Uglesić, Vedran
AU  - Kovacić, Ziga
AU  - Vesnaver, Ales
AU  - Konstantinović, Vitomir
AU  - Petrović, Milan
AU  - Stephens, Jonny
AU  - Kanzaria, Amar
AU  - Bhatti, Nabeel
AU  - Holmes, Simon
AU  - Pechalova, Petia
AU  - Bakardjiev, Angel G.
AU  - Malanchuk, Vladislav A.
AU  - Kopchak, Andrey
AU  - Galteland, Pal
AU  - Mjoen, Even
AU  - Skjelbred, Per
AU  - Bertin, Helios
AU  - Marion, F.
AU  - Guiol, Julien
AU  - Corre, Pierre
AU  - Loes, Sigbjorn
AU  - Lekven, Njal
AU  - Laverick, Sean
AU  - Gordon, Peter
AU  - Tamme, Tiia
AU  - Akermann, Stephanie
AU  - Karagozoglu, Hakki K.
AU  - Kommers, Sofie C.
AU  - Forouzanfar, Tymour
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1985
AB  - Objective. The aim of this study is to present and discuss the demographic characteristics and patterns of assault-related maxillofacial fractures as reported by a European multicenter prospective study. Study Design. Demographic and injury data were recorded for each patient who was a victim of an assault. Results. Assaults represented the most frequent etiology of maxillofacial trauma with an overall rate of 39% and the values ranging between 60.8% (Kiev, Ukraine) and 15.4% (Bergen, Norway). The most frequent mechanisms of assault-related maxillofacial fractures were fists in 730 cases, followed by kicks and fists. The most frequently observed fracture involved the mandible (814 fractures), followed by orbito-zygomatic-maxillary complex fractures and orbital fractures. Conclusions. Our data confirmed the strong possibility that patients with maxillofacial fractures may be victims of physical aggression. The crucial role of alcohol in assault-related fractures was also confirmed by our study.
PB  - Elsevier Science Inc, New York
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
T1  - Assault-related maxillofacial injuries: the results from the European Maxillofacial Trauma (EURMAT) multicenter and prospective collaboration
VL  - 119
IS  - 4
SP  - 385
EP  - 391
DO  - 10.1016/j.oooo.2014.12.004
ER  - 

@article{
author = "Boffano, Paolo and Roccia, Fabio and Zavattero, Emanuele and Dediol, Emil and Uglesić, Vedran and Kovacić, Ziga and Vesnaver, Ales and Konstantinović, Vitomir and Petrović, Milan and Stephens, Jonny and Kanzaria, Amar and Bhatti, Nabeel and Holmes, Simon and Pechalova, Petia and Bakardjiev, Angel G. and Malanchuk, Vladislav A. and Kopchak, Andrey and Galteland, Pal and Mjoen, Even and Skjelbred, Per and Bertin, Helios and Marion, F. and Guiol, Julien and Corre, Pierre and Loes, Sigbjorn and Lekven, Njal and Laverick, Sean and Gordon, Peter and Tamme, Tiia and Akermann, Stephanie and Karagozoglu, Hakki K. and Kommers, Sofie C. and Forouzanfar, Tymour",
year = "2015",
abstract = "Objective. The aim of this study is to present and discuss the demographic characteristics and patterns of assault-related maxillofacial fractures as reported by a European multicenter prospective study. Study Design. Demographic and injury data were recorded for each patient who was a victim of an assault. Results. Assaults represented the most frequent etiology of maxillofacial trauma with an overall rate of 39% and the values ranging between 60.8% (Kiev, Ukraine) and 15.4% (Bergen, Norway). The most frequent mechanisms of assault-related maxillofacial fractures were fists in 730 cases, followed by kicks and fists. The most frequently observed fracture involved the mandible (814 fractures), followed by orbito-zygomatic-maxillary complex fractures and orbital fractures. Conclusions. Our data confirmed the strong possibility that patients with maxillofacial fractures may be victims of physical aggression. The crucial role of alcohol in assault-related fractures was also confirmed by our study.",
publisher = "Elsevier Science Inc, New York",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology",
title = "Assault-related maxillofacial injuries: the results from the European Maxillofacial Trauma (EURMAT) multicenter and prospective collaboration",
volume = "119",
number = "4",
pages = "385-391",
doi = "10.1016/j.oooo.2014.12.004"
}

Boffano, P., Roccia, F., Zavattero, E., Dediol, E., Uglesić, V., Kovacić, Z., Vesnaver, A., Konstantinović, V., Petrović, M., Stephens, J., Kanzaria, A., Bhatti, N., Holmes, S., Pechalova, P., Bakardjiev, A. G., Malanchuk, V. A., Kopchak, A., Galteland, P., Mjoen, E., Skjelbred, P., Bertin, H., Marion, F., Guiol, J., Corre, P., Loes, S., Lekven, N., Laverick, S., Gordon, P., Tamme, T., Akermann, S., Karagozoglu, H. K., Kommers, S. C.,& Forouzanfar, T.. (2015). Assault-related maxillofacial injuries: the results from the European Maxillofacial Trauma (EURMAT) multicenter and prospective collaboration. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Elsevier Science Inc, New York., 119(4), 385-391.
https://doi.org/10.1016/j.oooo.2014.12.004

Boffano P, Roccia F, Zavattero E, Dediol E, Uglesić V, Kovacić Z, Vesnaver A, Konstantinović V, Petrović M, Stephens J, Kanzaria A, Bhatti N, Holmes S, Pechalova P, Bakardjiev AG, Malanchuk VA, Kopchak A, Galteland P, Mjoen E, Skjelbred P, Bertin H, Marion F, Guiol J, Corre P, Loes S, Lekven N, Laverick S, Gordon P, Tamme T, Akermann S, Karagozoglu HK, Kommers SC, Forouzanfar T. Assault-related maxillofacial injuries: the results from the European Maxillofacial Trauma (EURMAT) multicenter and prospective collaboration. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2015;119(4):385-391.
doi:10.1016/j.oooo.2014.12.004 .

Boffano, Paolo, Roccia, Fabio, Zavattero, Emanuele, Dediol, Emil, Uglesić, Vedran, Kovacić, Ziga, Vesnaver, Ales, Konstantinović, Vitomir, Petrović, Milan, Stephens, Jonny, Kanzaria, Amar, Bhatti, Nabeel, Holmes, Simon, Pechalova, Petia, Bakardjiev, Angel G., Malanchuk, Vladislav A., Kopchak, Andrey, Galteland, Pal, Mjoen, Even, Skjelbred, Per, Bertin, Helios, Marion, F., Guiol, Julien, Corre, Pierre, Loes, Sigbjorn, Lekven, Njal, Laverick, Sean, Gordon, Peter, Tamme, Tiia, Akermann, Stephanie, Karagozoglu, Hakki K., Kommers, Sofie C., Forouzanfar, Tymour, "Assault-related maxillofacial injuries: the results from the European Maxillofacial Trauma (EURMAT) multicenter and prospective collaboration" in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 119, no. 4 (2015):385-391,
https://doi.org/10.1016/j.oooo.2014.12.004 . .

TY  - JOUR
AU  - Boffano, Paolo
AU  - Roccia, Fabio
AU  - Zavattero, Emanuele
AU  - Dediol, Emil
AU  - Uglesić, Vedran
AU  - Kovacić, Ziga
AU  - Vesnaver, Ales
AU  - Konstantinović, Vitomir
AU  - Petrović, Milan
AU  - Stephens, Jonny
AU  - Kanzaria, Amar
AU  - Bhatti, Nabeel
AU  - Holmes, Simon
AU  - Pechalova, Petia
AU  - Bakardjiev, Angel G.
AU  - Malanchuk, Vladislav A.
AU  - Kopchak, Andrey
AU  - Galteland, Pal
AU  - Mjoen, Even
AU  - Skjelbred, Per
AU  - Grimaud, Fanny
AU  - Fauvel, Fabien
AU  - Longis, Julie
AU  - Corre, Pierre
AU  - Loes, Sigbjorn
AU  - Lekven, Njal
AU  - Laverick, Sean
AU  - Gordon, Peter
AU  - Tamme, Tiia
AU  - Akermann, Stephanie
AU  - Karagozoglu, Hakki K.
AU  - Kommers, Sofie C.
AU  - Meijer, Brigitte
AU  - Forouzanfar, Tymour
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1975
AB  - Objective. The aim of this study is to present and discuss the results of a European multicentre prospective study about pediatric maxillofacial trauma epidemiology during a year. Study Design. The following data were recorded: gender, age, etiology, site of fracture, date of injury. Of the 3396 patients with maxillofacial fractures admitted within the study period, 114 (3.3%) were children aged 15 years and younger, with a male/female ratio of 2.6:1. Mean age was 10.9 years. Most patients (63%) were aged 11-15 years. Results. The most frequent cause of injury was fall (36 patients). Sport injuries and assaults were almost limited to the oldest group, whereas falls were more uniformly distributed in the 3 groups. The most frequently observed fracture involved the mandible with 47 fractures. In particular, 18 condylar fractures were recorded, followed by 12 body fractures. Conclusions. Falls can be acknowledged as the most important cause of facial trauma during the first years of life. The high incidence of sport accidents after 10 years may be a reason to increase the use of mouthguards and other protective equipment. Finally, the mandible (and in particular the condyle) was confirmed as the most frequent fracture site.
PB  - Elsevier Science Inc, New York
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
T1  - European Maxillofacial Trauma (EURMAT) in children: A multicenter and prospective study
VL  - 119
IS  - 5
SP  - 499
EP  - 504
DO  - 10.1016/j.oooo.2014.12.012
ER  - 

@article{
author = "Boffano, Paolo and Roccia, Fabio and Zavattero, Emanuele and Dediol, Emil and Uglesić, Vedran and Kovacić, Ziga and Vesnaver, Ales and Konstantinović, Vitomir and Petrović, Milan and Stephens, Jonny and Kanzaria, Amar and Bhatti, Nabeel and Holmes, Simon and Pechalova, Petia and Bakardjiev, Angel G. and Malanchuk, Vladislav A. and Kopchak, Andrey and Galteland, Pal and Mjoen, Even and Skjelbred, Per and Grimaud, Fanny and Fauvel, Fabien and Longis, Julie and Corre, Pierre and Loes, Sigbjorn and Lekven, Njal and Laverick, Sean and Gordon, Peter and Tamme, Tiia and Akermann, Stephanie and Karagozoglu, Hakki K. and Kommers, Sofie C. and Meijer, Brigitte and Forouzanfar, Tymour",
year = "2015",
abstract = "Objective. The aim of this study is to present and discuss the results of a European multicentre prospective study about pediatric maxillofacial trauma epidemiology during a year. Study Design. The following data were recorded: gender, age, etiology, site of fracture, date of injury. Of the 3396 patients with maxillofacial fractures admitted within the study period, 114 (3.3%) were children aged 15 years and younger, with a male/female ratio of 2.6:1. Mean age was 10.9 years. Most patients (63%) were aged 11-15 years. Results. The most frequent cause of injury was fall (36 patients). Sport injuries and assaults were almost limited to the oldest group, whereas falls were more uniformly distributed in the 3 groups. The most frequently observed fracture involved the mandible with 47 fractures. In particular, 18 condylar fractures were recorded, followed by 12 body fractures. Conclusions. Falls can be acknowledged as the most important cause of facial trauma during the first years of life. The high incidence of sport accidents after 10 years may be a reason to increase the use of mouthguards and other protective equipment. Finally, the mandible (and in particular the condyle) was confirmed as the most frequent fracture site.",
publisher = "Elsevier Science Inc, New York",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology",
title = "European Maxillofacial Trauma (EURMAT) in children: A multicenter and prospective study",
volume = "119",
number = "5",
pages = "499-504",
doi = "10.1016/j.oooo.2014.12.012"
}

Boffano, P., Roccia, F., Zavattero, E., Dediol, E., Uglesić, V., Kovacić, Z., Vesnaver, A., Konstantinović, V., Petrović, M., Stephens, J., Kanzaria, A., Bhatti, N., Holmes, S., Pechalova, P., Bakardjiev, A. G., Malanchuk, V. A., Kopchak, A., Galteland, P., Mjoen, E., Skjelbred, P., Grimaud, F., Fauvel, F., Longis, J., Corre, P., Loes, S., Lekven, N., Laverick, S., Gordon, P., Tamme, T., Akermann, S., Karagozoglu, H. K., Kommers, S. C., Meijer, B.,& Forouzanfar, T.. (2015). European Maxillofacial Trauma (EURMAT) in children: A multicenter and prospective study. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Elsevier Science Inc, New York., 119(5), 499-504.
https://doi.org/10.1016/j.oooo.2014.12.012

Boffano P, Roccia F, Zavattero E, Dediol E, Uglesić V, Kovacić Z, Vesnaver A, Konstantinović V, Petrović M, Stephens J, Kanzaria A, Bhatti N, Holmes S, Pechalova P, Bakardjiev AG, Malanchuk VA, Kopchak A, Galteland P, Mjoen E, Skjelbred P, Grimaud F, Fauvel F, Longis J, Corre P, Loes S, Lekven N, Laverick S, Gordon P, Tamme T, Akermann S, Karagozoglu HK, Kommers SC, Meijer B, Forouzanfar T. European Maxillofacial Trauma (EURMAT) in children: A multicenter and prospective study. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2015;119(5):499-504.
doi:10.1016/j.oooo.2014.12.012 .

Boffano, Paolo, Roccia, Fabio, Zavattero, Emanuele, Dediol, Emil, Uglesić, Vedran, Kovacić, Ziga, Vesnaver, Ales, Konstantinović, Vitomir, Petrović, Milan, Stephens, Jonny, Kanzaria, Amar, Bhatti, Nabeel, Holmes, Simon, Pechalova, Petia, Bakardjiev, Angel G., Malanchuk, Vladislav A., Kopchak, Andrey, Galteland, Pal, Mjoen, Even, Skjelbred, Per, Grimaud, Fanny, Fauvel, Fabien, Longis, Julie, Corre, Pierre, Loes, Sigbjorn, Lekven, Njal, Laverick, Sean, Gordon, Peter, Tamme, Tiia, Akermann, Stephanie, Karagozoglu, Hakki K., Kommers, Sofie C., Meijer, Brigitte, Forouzanfar, Tymour, "European Maxillofacial Trauma (EURMAT) in children: A multicenter and prospective study" in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 119, no. 5 (2015):499-504,
https://doi.org/10.1016/j.oooo.2014.12.012 . .

TY  - JOUR
AU  - Gavrić, Miodrag
AU  - Antić, Svetlana
AU  - Jelovac, Drago
AU  - Zarev, Anita I.
AU  - Petrović, Milan
AU  - Golubović, Mileta
AU  - Antunović, Marija
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1906
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis
T1  - Osteonekroza vilica kao ozbiljan neželjeni efekat terapije bisfosfonatima i njegova nejasna etiopatogeneza
VL  - 71
IS  - 8
SP  - 772
EP  - 776
DO  - 10.2298/VSP121211025G
ER  - 

@article{
author = "Gavrić, Miodrag and Antić, Svetlana and Jelovac, Drago and Zarev, Anita I. and Petrović, Milan and Golubović, Mileta and Antunović, Marija",
year = "2014",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis, Osteonekroza vilica kao ozbiljan neželjeni efekat terapije bisfosfonatima i njegova nejasna etiopatogeneza",
volume = "71",
number = "8",
pages = "772-776",
doi = "10.2298/VSP121211025G"
}

Gavrić, M., Antić, S., Jelovac, D., Zarev, A. I., Petrović, M., Golubović, M.,& Antunović, M.. (2014). Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(8), 772-776.
https://doi.org/10.2298/VSP121211025G

Gavrić M, Antić S, Jelovac D, Zarev AI, Petrović M, Golubović M, Antunović M. Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis. in Vojnosanitetski pregled. 2014;71(8):772-776.
doi:10.2298/VSP121211025G .

Gavrić, Miodrag, Antić, Svetlana, Jelovac, Drago, Zarev, Anita I., Petrović, Milan, Golubović, Mileta, Antunović, Marija, "Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis" in Vojnosanitetski pregled, 71, no. 8 (2014):772-776,
https://doi.org/10.2298/VSP121211025G . .

TY  - JOUR
AU  - Čolović, Božana
AU  - Marković, D.
AU  - Petrović, Milan
AU  - Jokanović, Vukoman
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1932
AB  - In this paper, the synthesis and characterization of calcium hydroxyapatite particles, stabilized with poly(ethylene-vinyl acetate) / poly(ethylene-vinyl versatate) (PEVA/PEVV) are presented. The particles were synthesized by two-step hydrothermal method using PEVA/PEVV as a surface-active substance. The structure and crystallinity of the obtained powder were investigated by X-ray diffraction, TEM and HRTEM. The phase identification of hydroxyapatite stabilized with PEVA/PEVV was done by FTIR, while the surface morphology, as well as the size and shape of particles were studied by TEM and AFM. Finally, using MTT and LDH release assays to assess mitochondrial activity and cell membrane integrity, it was confirmed that so synthesized hydroxyapatite powder was not toxic to L929 cells.
PB  - National Institute of Optoelectronics
T2  - Journal of Optoelectronics & Advanced Materials
T1  - Two-step hydrothermal synthesis of nano hydroxyapatite particles and their characterization
VL  - 16
IS  - 11-12
SP  - 1356
EP  - 1360
UR  - https://hdl.handle.net/21.15107/rcub_vinar_339
ER  - 

@article{
author = "Čolović, Božana and Marković, D. and Petrović, Milan and Jokanović, Vukoman",
year = "2014",
abstract = "In this paper, the synthesis and characterization of calcium hydroxyapatite particles, stabilized with poly(ethylene-vinyl acetate) / poly(ethylene-vinyl versatate) (PEVA/PEVV) are presented. The particles were synthesized by two-step hydrothermal method using PEVA/PEVV as a surface-active substance. The structure and crystallinity of the obtained powder were investigated by X-ray diffraction, TEM and HRTEM. The phase identification of hydroxyapatite stabilized with PEVA/PEVV was done by FTIR, while the surface morphology, as well as the size and shape of particles were studied by TEM and AFM. Finally, using MTT and LDH release assays to assess mitochondrial activity and cell membrane integrity, it was confirmed that so synthesized hydroxyapatite powder was not toxic to L929 cells.",
publisher = "National Institute of Optoelectronics",
journal = "Journal of Optoelectronics & Advanced Materials",
title = "Two-step hydrothermal synthesis of nano hydroxyapatite particles and their characterization",
volume = "16",
number = "11-12",
pages = "1356-1360",
url = "https://hdl.handle.net/21.15107/rcub_vinar_339"
}

Čolović, B., Marković, D., Petrović, M.,& Jokanović, V.. (2014). Two-step hydrothermal synthesis of nano hydroxyapatite particles and their characterization. in Journal of Optoelectronics & Advanced Materials
National Institute of Optoelectronics., 16(11-12), 1356-1360.
https://hdl.handle.net/21.15107/rcub_vinar_339

Čolović B, Marković D, Petrović M, Jokanović V. Two-step hydrothermal synthesis of nano hydroxyapatite particles and their characterization. in Journal of Optoelectronics & Advanced Materials. 2014;16(11-12):1356-1360.
https://hdl.handle.net/21.15107/rcub_vinar_339 .

Čolović, Božana, Marković, D., Petrović, Milan, Jokanović, Vukoman, "Two-step hydrothermal synthesis of nano hydroxyapatite particles and their characterization" in Journal of Optoelectronics & Advanced Materials, 16, no. 11-12 (2014):1356-1360,
https://hdl.handle.net/21.15107/rcub_vinar_339 .

TY  - JOUR
AU  - Golubović, Mileta
AU  - Petrović, Milan
AU  - Jelovac, Drago
AU  - Nenezić, Dragoslav U.
AU  - Antunović, Marija
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1718
AB  - Introduction. Ameloblastomas are odontogenic epithelial, locally invasive tumors of slow growth and mostly of benign behavior. Their frequency is low (they account for 1% of all head and neck tumors and about 11% of tumors of dental origin). Malignant variations of ameloblastoma are malignant ameloblastoma and ameloblastic carcinoma. They constitute less than 1% of all ameloblastomas. We presented a case of malignant ameloblastoma of the mandible with neck metastasis. Case report. A patient, aged 72, presented with the following symptoms: pain in the lower jaw, swelling in the left submandibular area and difficult mouth opening. The patient was admitted to the Department of Oral and Maxillofacial Surgery, Clinical Center of Montenegro, two months after he had noticed the symptoms. Panoramic radiography (OPG) showed that both jaws were partially toothless with terminal stage of periodontitis of the remaining teeth. Also, OPG showed sharply limited semicircular defect in the retromolar region and along the front edge of the mandible rami. Conventional histopathologic examination of the neck masses showed malignant ameloblastoma which contained central fields of squamous differentiation. Immunoreactivity of several markers was determined using immunohistochemical analyses. After these diagnostic methods a definite histopathology diagnosis was made: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Conclusion. It is not possible to distinguish conventional, ie intraosseous, ameloblastoma from malignant ameloblastoma according to histopathologic features. It is necessary to pay special attention, especially in elderly patients, and to carry out further clinical, radiological and pathohistological diagnostic procedures, such as immunohistochemical analysis. A timely and correct diagnosis and treatment of malignant ameloblastoma require a multidisciplinary approach.
AB  - Uvod. Ameloblastomi su odontogeni epitelni tumori, lokalno invazivni, sporog rasta, i u većini slučajeva pokazuju benigno ponašanje. Veoma su rijetki. Njihova učestalost je 1% u grupi tumora glave i vrata, kao i 11% kod tumora koji potiču od zubnih tkiva. Maligne varijante ameloblastoma su maligni ameloblastom i ameloblastički karcinom. Oni čine manje od 1% svih ameloblastoma. U radu je prikazan bolesnik sa malignim ameloblastomom donje vilice sa metastazom na vratu. Prikaz bolesnika. Prve subjektivne tegobe bolesnika, starog 72 godine, manifestovale su se kao bolovi u predelu donje vilice, otok u podviličnom predelu sa leve strane i otežano otvaranje usta. Bolesnik je primljen u Odeljenje oralne i maksilofacijalne hirurgije Kliničkog centra Crne Gore dva meseca nakon što je primetio prve tegobe. Ortopantomografski snimak pokazao je suptotalnu bezubost obeju vilica sa terminalnim stadijumom parodontopatije na preostalim zubima. U retromolarnoj regiji i duž prednje ivice ramusa donje vilice, uočen je jasno ograničen polukružni defekt. Biopsija promene na vratu pokazala je metastazu malignog ameloblastoma, sa prisutnim centralnim poljima skvamozne diferencijacije. Imunohistohemijskom analizom određivana je imunoreaktivnost više markera. Nakon ovih dijagnostičkih metoda postavljena je definitivna patohistološka dijagnoza: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Zaključak. Na osnovu histopatološkog nalaza nije moguće razlikovati konvencionalni, tj. intraosealni, ameloblastom od malignog ameloblastoma. Zbog toga je potrebno obratiti posebnu pažnju, naro čito kod bolesnika starijeg životnog doba, i sprovesti sve dodatne kliničke, radiološke i histopatološke, ali i imunohistohemijske dijagnostičke procedure. Za postavljanje blagovremene i tačne dijagnoze, kao i sprovođenje adekvatnog terapijskog tretmana malignog ameloblastoma, neophodan je multidisciplinarni pristup.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma
T1  - Metastaza malignog ameloblastoma na vratu - radiološka i patohistološka dilema
VL  - 69
IS  - 5
SP  - 444
EP  - 448
DO  - 10.2298/VSP1205444G
ER  - 

@article{
author = "Golubović, Mileta and Petrović, Milan and Jelovac, Drago and Nenezić, Dragoslav U. and Antunović, Marija",
year = "2012",
abstract = "Introduction. Ameloblastomas are odontogenic epithelial, locally invasive tumors of slow growth and mostly of benign behavior. Their frequency is low (they account for 1% of all head and neck tumors and about 11% of tumors of dental origin). Malignant variations of ameloblastoma are malignant ameloblastoma and ameloblastic carcinoma. They constitute less than 1% of all ameloblastomas. We presented a case of malignant ameloblastoma of the mandible with neck metastasis. Case report. A patient, aged 72, presented with the following symptoms: pain in the lower jaw, swelling in the left submandibular area and difficult mouth opening. The patient was admitted to the Department of Oral and Maxillofacial Surgery, Clinical Center of Montenegro, two months after he had noticed the symptoms. Panoramic radiography (OPG) showed that both jaws were partially toothless with terminal stage of periodontitis of the remaining teeth. Also, OPG showed sharply limited semicircular defect in the retromolar region and along the front edge of the mandible rami. Conventional histopathologic examination of the neck masses showed malignant ameloblastoma which contained central fields of squamous differentiation. Immunoreactivity of several markers was determined using immunohistochemical analyses. After these diagnostic methods a definite histopathology diagnosis was made: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Conclusion. It is not possible to distinguish conventional, ie intraosseous, ameloblastoma from malignant ameloblastoma according to histopathologic features. It is necessary to pay special attention, especially in elderly patients, and to carry out further clinical, radiological and pathohistological diagnostic procedures, such as immunohistochemical analysis. A timely and correct diagnosis and treatment of malignant ameloblastoma require a multidisciplinary approach., Uvod. Ameloblastomi su odontogeni epitelni tumori, lokalno invazivni, sporog rasta, i u većini slučajeva pokazuju benigno ponašanje. Veoma su rijetki. Njihova učestalost je 1% u grupi tumora glave i vrata, kao i 11% kod tumora koji potiču od zubnih tkiva. Maligne varijante ameloblastoma su maligni ameloblastom i ameloblastički karcinom. Oni čine manje od 1% svih ameloblastoma. U radu je prikazan bolesnik sa malignim ameloblastomom donje vilice sa metastazom na vratu. Prikaz bolesnika. Prve subjektivne tegobe bolesnika, starog 72 godine, manifestovale su se kao bolovi u predelu donje vilice, otok u podviličnom predelu sa leve strane i otežano otvaranje usta. Bolesnik je primljen u Odeljenje oralne i maksilofacijalne hirurgije Kliničkog centra Crne Gore dva meseca nakon što je primetio prve tegobe. Ortopantomografski snimak pokazao je suptotalnu bezubost obeju vilica sa terminalnim stadijumom parodontopatije na preostalim zubima. U retromolarnoj regiji i duž prednje ivice ramusa donje vilice, uočen je jasno ograničen polukružni defekt. Biopsija promene na vratu pokazala je metastazu malignog ameloblastoma, sa prisutnim centralnim poljima skvamozne diferencijacije. Imunohistohemijskom analizom određivana je imunoreaktivnost više markera. Nakon ovih dijagnostičkih metoda postavljena je definitivna patohistološka dijagnoza: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Zaključak. Na osnovu histopatološkog nalaza nije moguće razlikovati konvencionalni, tj. intraosealni, ameloblastom od malignog ameloblastoma. Zbog toga je potrebno obratiti posebnu pažnju, naro čito kod bolesnika starijeg životnog doba, i sprovesti sve dodatne kliničke, radiološke i histopatološke, ali i imunohistohemijske dijagnostičke procedure. Za postavljanje blagovremene i tačne dijagnoze, kao i sprovođenje adekvatnog terapijskog tretmana malignog ameloblastoma, neophodan je multidisciplinarni pristup.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma, Metastaza malignog ameloblastoma na vratu - radiološka i patohistološka dilema",
volume = "69",
number = "5",
pages = "444-448",
doi = "10.2298/VSP1205444G"
}

Golubović, M., Petrović, M., Jelovac, D., Nenezić, D. U.,& Antunović, M.. (2012). Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 69(5), 444-448.
https://doi.org/10.2298/VSP1205444G

Golubović M, Petrović M, Jelovac D, Nenezić DU, Antunović M. Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma. in Vojnosanitetski pregled. 2012;69(5):444-448.
doi:10.2298/VSP1205444G .

Golubović, Mileta, Petrović, Milan, Jelovac, Drago, Nenezić, Dragoslav U., Antunović, Marija, "Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma" in Vojnosanitetski pregled, 69, no. 5 (2012):444-448,
https://doi.org/10.2298/VSP1205444G . .

TY  - JOUR
AU  - Petrović, Milan
AU  - Čolović, Božana
AU  - Jokanović, Vukoman
AU  - Marković, Dejan
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1692
AB  - The role of the process of designing a scaffold in bone tissue engineering is to provide optimal conditions for new bone tissue growth. The primary concern of such engineering is to create an adequate nanotopology of the scaffold inner walls, which can initiate the growth and activity of bone cells. Here, we present a completely new scaffold designing process based on a biomimetic approach in order to improve the nanostructure of pore walls of previously-made calcium hydroxyapatite (CHA) porous scaffolds. CHA porous scaffolds were covered with different polymer thin films (alginate, cellulose and PLGA) and exposed to simulated body fluid (SBF) for 42 days. SBF induced in situ formation of "bone-like" apatite phases on the surface of CHA/polymer composites. Fourier Transformed Infrared (FTIR) spectroscopy showed that the biomimetically-assembled phase is CHA of slightly shifted stoichiometry. X-ray diffraction confirmed that CHA is self-assembled on the surface of all investigated thin films. The calculation of crystallite sizes showed small differences in the degree of crystallinity between different samples. Scanning electron microscopy revealed a dominant blow-ball morphology of CHA particles (size 1 - 5 mu m) with nano-sized branches on their surfaces.
T2  - Journal of Ceramic Processing Research
T1  - Self assembly of biomimetic hydroxyapatite on the surface of different polymer thin films
VL  - 13
IS  - 4
SP  - 398
EP  - 404
UR  - https://hdl.handle.net/21.15107/rcub_vinar_5031
ER  - 

@article{
author = "Petrović, Milan and Čolović, Božana and Jokanović, Vukoman and Marković, Dejan",
year = "2012",
abstract = "The role of the process of designing a scaffold in bone tissue engineering is to provide optimal conditions for new bone tissue growth. The primary concern of such engineering is to create an adequate nanotopology of the scaffold inner walls, which can initiate the growth and activity of bone cells. Here, we present a completely new scaffold designing process based on a biomimetic approach in order to improve the nanostructure of pore walls of previously-made calcium hydroxyapatite (CHA) porous scaffolds. CHA porous scaffolds were covered with different polymer thin films (alginate, cellulose and PLGA) and exposed to simulated body fluid (SBF) for 42 days. SBF induced in situ formation of "bone-like" apatite phases on the surface of CHA/polymer composites. Fourier Transformed Infrared (FTIR) spectroscopy showed that the biomimetically-assembled phase is CHA of slightly shifted stoichiometry. X-ray diffraction confirmed that CHA is self-assembled on the surface of all investigated thin films. The calculation of crystallite sizes showed small differences in the degree of crystallinity between different samples. Scanning electron microscopy revealed a dominant blow-ball morphology of CHA particles (size 1 - 5 mu m) with nano-sized branches on their surfaces.",
journal = "Journal of Ceramic Processing Research",
title = "Self assembly of biomimetic hydroxyapatite on the surface of different polymer thin films",
volume = "13",
number = "4",
pages = "398-404",
url = "https://hdl.handle.net/21.15107/rcub_vinar_5031"
}

Petrović, M., Čolović, B., Jokanović, V.,& Marković, D.. (2012). Self assembly of biomimetic hydroxyapatite on the surface of different polymer thin films. in Journal of Ceramic Processing Research, 13(4), 398-404.
https://hdl.handle.net/21.15107/rcub_vinar_5031

Petrović M, Čolović B, Jokanović V, Marković D. Self assembly of biomimetic hydroxyapatite on the surface of different polymer thin films. in Journal of Ceramic Processing Research. 2012;13(4):398-404.
https://hdl.handle.net/21.15107/rcub_vinar_5031 .

Petrović, Milan, Čolović, Božana, Jokanović, Vukoman, Marković, Dejan, "Self assembly of biomimetic hydroxyapatite on the surface of different polymer thin films" in Journal of Ceramic Processing Research, 13, no. 4 (2012):398-404,
https://hdl.handle.net/21.15107/rcub_vinar_5031 .

TY  - THES
AU  - Petrović, Milan
PY  - 2012
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=575
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:6733/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024188046
UR  - http://nardus.mpn.gov.rs/123456789/2685
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/962
AB  - Since the beginning of this century the bone tissue engineering has developed into one of the essential research fields in reconstructive medicine, as an alternative approach compared with the conventional bone transplants. The main objective of this kind of therapy is to repair, regenerate and reconstruct the damaged or disease-stricken tissue. Tissue engineering is based on scaffolds which are of various biomaterials capable of participating in the process of bone tissue regeneration. A great number of materials has been researched and analyzed so as to be used as a scaffold for cell seeding. Therefore, the scaffold would enable those cells to grow, proliferate and penetrate the bone defects, whereupon the new tissue would take over the structure and function of the damaged tissue. Hydroxyapatites and other calcium phosphate materials were widely used as bone replacements for more than two decades. However, the poor mechanical features of porous hydroxyapatites led to their limited use. In case when they are combined into the compound materials together with polymer/biopolymer thin films, the porous hydroxyapatites acquire optimal characteristics required by scaffolds, which can offer excellent conditions for cell infiltration, growth and activity which is necessary in bone tissue engineering. The main objective of the doctoral dissertation was to carry out the characterization, examine the biocompatibility and biofunctionality of porous hydroxyapatite created by the modified hydrothermal method (pHAP), porous hydroxyapatite created by the modified hydrothermal method in combination with PLGA (Phap + PLGA) and porous hydroxyapatite created by the modified hydrothermal method in combination with metformin (pHAP + metformin). The research included the characterization of the tested materials by means of Fourier transform infrared spectroscopy (FTIR), X-ray distraction method (XRD), atomic forse microscopy method (AFM), scanning electorn microscopy analysis(SEM) and BET method. Biocompatibility was examined by MTT test (indirect contact of the tested materials with the cell culture L 929 fibroblasts), LDH test (direct contact of the tested materilas with the cell culture L929 fribroblasts) and test of local effects on skin in rabbits. Biofunctionality of the examined materials was researched by their implatation into defects of critical size of 6mm in the region of parietal bone in rabbits. After 12 weeks the animals were sacrifised, and tissue samples were prepared for pathohistological analysis. By means of the optical microscopy the following parametres were determined both quantitatively and qualitatively: the size of the defect, the presence of giant cells, the presence of neoangiogenesis, the presence of basophils, the presence of nonspecific inflammation in the tissue, the appearance of the newly created bone, the presence of fibroplasia in the tissue and the percentage of mineralization...
AB  - Tkivno inženjerstvo koštanog tkiva se u ovom veku razvilo u jedno od glavnih polja istraživanja u regenerativnoj medicini. Ono predstavlja alternativni pristup u odnosu na konvencionalne koštane transplantate. Osnovni cilj ove vrste terapije je da popravi, regeneriše i rekonstruiše oštećeno ili bolešću zahvaćeno tkivo. Osnovu tkivnog inženjerstva čine ćelijski nosači koji predstavljaju razne vrste biomaterijala sposobnih da učestvuju u regeneraciji koštanog tkiva. Veliki broj materijala je istraživan i analiziran sa ciljem da se koristi kao ćelijski nosač na koji bi mogle da se zasejavaju ćelije. Ćelijski nosač koji bi tim ćelijama omogućio rast, proliferaciju i njihovo unošenje u defekte kosti nakon čega bi novostvoreno tkivo preuzimalo strukturu i funkciju obolelog dela tkiva. Hidroksiapatiti i drugi kalcijum fosfatni materijali imali su široku upotrebu kao koštani zamenici više od dve decenije. Zbog loših mehaničkih osobina poroznih hidroksiapatita došlo je do ograničenja njihove primene. U slučaju kada se kombinuju u kompozitne materijale sa odgovarajućim polimer/biopolimer tankim filmovima, porozni hidroksiapatiti dobijaju optimalne osobine potrebne ćelijskim nosačima, koje mogu pružiti odlične uslove za infiltraciju, rast i aktivnost ćelija neophodnih u tkivnom inženjerstvu kosti. Osnovni cilj doktorske disertacije bio je izvršiti karakterizaciju, ispitati biokompatibilnost i biofunkcionalnost poroznog hidroksiapatita dobijenog modifikovanom hidrotermalnom metodom(pHAP), poroznog hidroksiapatita dobijenog modifikovanom hidrotermalnom metodom u kombinaciji sa PLGA (pHAP+PLGA) i poroznog hidroksiapatita dobijenog modifikovanom hidrotermalnom metodom u kombinaciji sa metforminom (pHAP+metformin). Istraživanje je podrazumevalo karakterizaciju ispitivanih materijala uz pomoć Fourier transform infracrvene spektroskopije (FTIR), metodom rentgen difrakcije (XRD), metodom atomski forsirane mikroskopije (AFM), analizom skening elektronske mikroskopije (SEM) i BET metodom. Biokompatibilnost je ispitivana pomoću MTT testa (indirektni kontakt ispitivanih materijala sa ćelijskom kulturom L 929 fibroblasta), LDH testa (direktni kontakt ispitivanih materijala sa ćelijskom kulturom L 929 fibroblasta) i testom kutane iritacije. Biofunkcionalnost ispitivanih materijala bila je istraživana njihovom implantacijom u defekte kritične veličine od 6 mm u predelu kalvarije kunića. Nakon 12 nedelja životinje su bile žrtvovane, a uzorci tkiva su obrađeni za patohistološku analizu. Optičkom mikroskopijom kvantitativno i kvalitativno obrađivani su sledeći parametri: veličina defekta, prisustvo džinovskih ćelija, prisustvo neoangiogeneze, prisustvo bazofila, postojanje znakova nespecifičnog zapaljenja u tkivu, pojava novostvorene kosti, prisustvo fibroplazije u tkivu i procenat mineralizacije...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Biological activity of the compound scaffolds based on highly porous hydroxyapatite and their influence on bone tissue engineering
T1  - Biološka aktivnost kompozitnih ćelijskih nosača na bazi visokoporoznih hidroksiapatita i njihov uticaj na tkivno inženjerstvo kosti
UR  - https://hdl.handle.net/21.15107/rcub_nardus_2685
ER  - 

@phdthesis{
author = "Petrović, Milan",
year = "2012",
abstract = "Since the beginning of this century the bone tissue engineering has developed into one of the essential research fields in reconstructive medicine, as an alternative approach compared with the conventional bone transplants. The main objective of this kind of therapy is to repair, regenerate and reconstruct the damaged or disease-stricken tissue. Tissue engineering is based on scaffolds which are of various biomaterials capable of participating in the process of bone tissue regeneration. A great number of materials has been researched and analyzed so as to be used as a scaffold for cell seeding. Therefore, the scaffold would enable those cells to grow, proliferate and penetrate the bone defects, whereupon the new tissue would take over the structure and function of the damaged tissue. Hydroxyapatites and other calcium phosphate materials were widely used as bone replacements for more than two decades. However, the poor mechanical features of porous hydroxyapatites led to their limited use. In case when they are combined into the compound materials together with polymer/biopolymer thin films, the porous hydroxyapatites acquire optimal characteristics required by scaffolds, which can offer excellent conditions for cell infiltration, growth and activity which is necessary in bone tissue engineering. The main objective of the doctoral dissertation was to carry out the characterization, examine the biocompatibility and biofunctionality of porous hydroxyapatite created by the modified hydrothermal method (pHAP), porous hydroxyapatite created by the modified hydrothermal method in combination with PLGA (Phap + PLGA) and porous hydroxyapatite created by the modified hydrothermal method in combination with metformin (pHAP + metformin). The research included the characterization of the tested materials by means of Fourier transform infrared spectroscopy (FTIR), X-ray distraction method (XRD), atomic forse microscopy method (AFM), scanning electorn microscopy analysis(SEM) and BET method. Biocompatibility was examined by MTT test (indirect contact of the tested materials with the cell culture L 929 fibroblasts), LDH test (direct contact of the tested materilas with the cell culture L929 fribroblasts) and test of local effects on skin in rabbits. Biofunctionality of the examined materials was researched by their implatation into defects of critical size of 6mm in the region of parietal bone in rabbits. After 12 weeks the animals were sacrifised, and tissue samples were prepared for pathohistological analysis. By means of the optical microscopy the following parametres were determined both quantitatively and qualitatively: the size of the defect, the presence of giant cells, the presence of neoangiogenesis, the presence of basophils, the presence of nonspecific inflammation in the tissue, the appearance of the newly created bone, the presence of fibroplasia in the tissue and the percentage of mineralization..., Tkivno inženjerstvo koštanog tkiva se u ovom veku razvilo u jedno od glavnih polja istraživanja u regenerativnoj medicini. Ono predstavlja alternativni pristup u odnosu na konvencionalne koštane transplantate. Osnovni cilj ove vrste terapije je da popravi, regeneriše i rekonstruiše oštećeno ili bolešću zahvaćeno tkivo. Osnovu tkivnog inženjerstva čine ćelijski nosači koji predstavljaju razne vrste biomaterijala sposobnih da učestvuju u regeneraciji koštanog tkiva. Veliki broj materijala je istraživan i analiziran sa ciljem da se koristi kao ćelijski nosač na koji bi mogle da se zasejavaju ćelije. Ćelijski nosač koji bi tim ćelijama omogućio rast, proliferaciju i njihovo unošenje u defekte kosti nakon čega bi novostvoreno tkivo preuzimalo strukturu i funkciju obolelog dela tkiva. Hidroksiapatiti i drugi kalcijum fosfatni materijali imali su široku upotrebu kao koštani zamenici više od dve decenije. Zbog loših mehaničkih osobina poroznih hidroksiapatita došlo je do ograničenja njihove primene. U slučaju kada se kombinuju u kompozitne materijale sa odgovarajućim polimer/biopolimer tankim filmovima, porozni hidroksiapatiti dobijaju optimalne osobine potrebne ćelijskim nosačima, koje mogu pružiti odlične uslove za infiltraciju, rast i aktivnost ćelija neophodnih u tkivnom inženjerstvu kosti. Osnovni cilj doktorske disertacije bio je izvršiti karakterizaciju, ispitati biokompatibilnost i biofunkcionalnost poroznog hidroksiapatita dobijenog modifikovanom hidrotermalnom metodom(pHAP), poroznog hidroksiapatita dobijenog modifikovanom hidrotermalnom metodom u kombinaciji sa PLGA (pHAP+PLGA) i poroznog hidroksiapatita dobijenog modifikovanom hidrotermalnom metodom u kombinaciji sa metforminom (pHAP+metformin). Istraživanje je podrazumevalo karakterizaciju ispitivanih materijala uz pomoć Fourier transform infracrvene spektroskopije (FTIR), metodom rentgen difrakcije (XRD), metodom atomski forsirane mikroskopije (AFM), analizom skening elektronske mikroskopije (SEM) i BET metodom. Biokompatibilnost je ispitivana pomoću MTT testa (indirektni kontakt ispitivanih materijala sa ćelijskom kulturom L 929 fibroblasta), LDH testa (direktni kontakt ispitivanih materijala sa ćelijskom kulturom L 929 fibroblasta) i testom kutane iritacije. Biofunkcionalnost ispitivanih materijala bila je istraživana njihovom implantacijom u defekte kritične veličine od 6 mm u predelu kalvarije kunića. Nakon 12 nedelja životinje su bile žrtvovane, a uzorci tkiva su obrađeni za patohistološku analizu. Optičkom mikroskopijom kvantitativno i kvalitativno obrađivani su sledeći parametri: veličina defekta, prisustvo džinovskih ćelija, prisustvo neoangiogeneze, prisustvo bazofila, postojanje znakova nespecifičnog zapaljenja u tkivu, pojava novostvorene kosti, prisustvo fibroplazije u tkivu i procenat mineralizacije...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Biological activity of the compound scaffolds based on highly porous hydroxyapatite and their influence on bone tissue engineering, Biološka aktivnost kompozitnih ćelijskih nosača na bazi visokoporoznih hidroksiapatita i njihov uticaj na tkivno inženjerstvo kosti",
url = "https://hdl.handle.net/21.15107/rcub_nardus_2685"
}

Petrović, M.. (2012). Biological activity of the compound scaffolds based on highly porous hydroxyapatite and their influence on bone tissue engineering. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_2685

Petrović M. Biological activity of the compound scaffolds based on highly porous hydroxyapatite and their influence on bone tissue engineering. 2012;.
https://hdl.handle.net/21.15107/rcub_nardus_2685 .

Petrović, Milan, "Biological activity of the compound scaffolds based on highly porous hydroxyapatite and their influence on bone tissue engineering" (2012),
https://hdl.handle.net/21.15107/rcub_nardus_2685 .

TY  - JOUR
AU  - Golubović, Mileta
AU  - Ašanin, Bogdan
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Antunović, Marija
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1536
AB  - The most common malignancy of the lip is squamous cell carcinoma (SCC). In our population, according to epidemiological data, almost a half of all (45%) SCC of oral mucous tissue spreads over the lower and upper lip. The aim of this study was to estimate prognostic importance of histopathologic characteristics - histologic grade, nuclear grade and tumor size in relation to the appearance of lymph node metastases and relapse in SCC of the lip. Methods. In the retrospective- prospective study 70 cases of lower and upper lip SCC were analyzed. They were diagnosed from 2002 to 2006 in the Clinic of Maxillofacial Surgery, Clinical Center of Montenegro. The data about localization of the carcinomas, histopathologic characteristics and lymph node status were taken from medical files of the patients. The patients were followed up in a 3-year period and the disease relapse or/and metastatic disease appearance were registereds. Results. There was statistically significant difference in tumor size among the patients with and without disease relapse (p = 0.027). Logistic regression analysis showed that the tumor size is a statistically significant factor (R = 0.186; p = 0.011) for the appearance of regional lymph node metastases. Relative risk [exp (B)] for the appearance of regional lymph node metastases in relation to tumor size was 2.807. Conclusion. Histologic and nuclear grade of lip SCC are not prognostic factors for the appearance of the disease relapse and regional lymph node metastases. Tumor size is a predictive factor of the relapse appearance, as well as for lymph node metastases appearance. In clinical practice, tumor size is a factor that classifies patients with lip SCC into the groups of higher and smaller risk of relapse appearance and for lymph node metastases appearance. Our results suggest that, risk for lymph node metastases appearance increases 2.8 times with increasing of the tumor size over 2 cm in diameter.
AB  - Uvod/Cilj. Planocelularni karcinom (PCC) je najčešće maligno oboljenje usne. Prema epidemiološkim podacima, u našoj populaciji skoro polovina (45%) PCC sluzokože usne duplje zahvata i donju i gornju usnu. Cilj ovog rada bio je utvrđivanje prognostičkog značaja histopatoloških karakteristika PCC usne: histološkog gradusa, nuklearnog gradusa i veličine tumora za pojavu recidiva bolesti i metastaza u regionalnim limfnim čvorovima. Metode. U retrospektivno-prospektivnoj studiji analizirano je 70 bolesnika sa PCC donje i gornje usne, dijagnostikovanim u periodu od 2002. do 2006. godine u Klinici za maksilofacijalnu hirurgiju Kliničkog centra Crne Gore. Podaci o lokalizaciji neoplazmi, životnom dobu i polu bolesnika, kao i o histopatološkim karakteristikama neoplazmi uzeti su iz uputnika za histopatološki pregled. Tokom tri godine, na redovnim postoperativnim kliničkim kontrolama, registrovana je eventualna pojava recidiva i/ili metastatske bolesti. Rezultati. Veličina tumora se statistički značajno razlikovala između ispitanika sa i bez recidiva bolesti (p = 0,027). Logističkom regresionom analizom utvrđeno je da je veličina tumora bila statistički značajan faktor (p = 0,011, R = 0,186) za pojavu metastaza u regionalnim limfnim čvorovima. Relativni rizik [exp (B)] od pojave metastaze u regionalnim limfnim čvorovima u odnosu na veličinu tumora iznosio je 2,807. Zaključak. Histološki i nuklearni gradusi tumora nisu prognostički faktori pojave recidiva i metastatske bolesti PCC usne. Veličina tumora predstavlja prognostički faktor za pojavu recidiva i regionalnih metastaza PCC usne, tj. faktor koji omogućava podelu bolesnika sa karcinomom usne u grupu sa većim, odnosno manjim rizikom od pojave recidiva i/ili metastatske bolesti. Prema našim rezultatima, sa povećanjem veličine PCC usne iznad 2 cm rizik od pojave regionalnih metastaza povećava se 2,8 puta.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma
T1  - Povezanost histopatoloških karakteristika karcinoma usne sa progresijom bolesti
VL  - 67
IS  - 1
SP  - 19
EP  - 24
DO  - 10.2298/VSP1001019G
ER  - 

@article{
author = "Golubović, Mileta and Ašanin, Bogdan and Jelovac, Drago and Petrović, Milan and Antunović, Marija",
year = "2010",
abstract = "The most common malignancy of the lip is squamous cell carcinoma (SCC). In our population, according to epidemiological data, almost a half of all (45%) SCC of oral mucous tissue spreads over the lower and upper lip. The aim of this study was to estimate prognostic importance of histopathologic characteristics - histologic grade, nuclear grade and tumor size in relation to the appearance of lymph node metastases and relapse in SCC of the lip. Methods. In the retrospective- prospective study 70 cases of lower and upper lip SCC were analyzed. They were diagnosed from 2002 to 2006 in the Clinic of Maxillofacial Surgery, Clinical Center of Montenegro. The data about localization of the carcinomas, histopathologic characteristics and lymph node status were taken from medical files of the patients. The patients were followed up in a 3-year period and the disease relapse or/and metastatic disease appearance were registereds. Results. There was statistically significant difference in tumor size among the patients with and without disease relapse (p = 0.027). Logistic regression analysis showed that the tumor size is a statistically significant factor (R = 0.186; p = 0.011) for the appearance of regional lymph node metastases. Relative risk [exp (B)] for the appearance of regional lymph node metastases in relation to tumor size was 2.807. Conclusion. Histologic and nuclear grade of lip SCC are not prognostic factors for the appearance of the disease relapse and regional lymph node metastases. Tumor size is a predictive factor of the relapse appearance, as well as for lymph node metastases appearance. In clinical practice, tumor size is a factor that classifies patients with lip SCC into the groups of higher and smaller risk of relapse appearance and for lymph node metastases appearance. Our results suggest that, risk for lymph node metastases appearance increases 2.8 times with increasing of the tumor size over 2 cm in diameter., Uvod/Cilj. Planocelularni karcinom (PCC) je najčešće maligno oboljenje usne. Prema epidemiološkim podacima, u našoj populaciji skoro polovina (45%) PCC sluzokože usne duplje zahvata i donju i gornju usnu. Cilj ovog rada bio je utvrđivanje prognostičkog značaja histopatoloških karakteristika PCC usne: histološkog gradusa, nuklearnog gradusa i veličine tumora za pojavu recidiva bolesti i metastaza u regionalnim limfnim čvorovima. Metode. U retrospektivno-prospektivnoj studiji analizirano je 70 bolesnika sa PCC donje i gornje usne, dijagnostikovanim u periodu od 2002. do 2006. godine u Klinici za maksilofacijalnu hirurgiju Kliničkog centra Crne Gore. Podaci o lokalizaciji neoplazmi, životnom dobu i polu bolesnika, kao i o histopatološkim karakteristikama neoplazmi uzeti su iz uputnika za histopatološki pregled. Tokom tri godine, na redovnim postoperativnim kliničkim kontrolama, registrovana je eventualna pojava recidiva i/ili metastatske bolesti. Rezultati. Veličina tumora se statistički značajno razlikovala između ispitanika sa i bez recidiva bolesti (p = 0,027). Logističkom regresionom analizom utvrđeno je da je veličina tumora bila statistički značajan faktor (p = 0,011, R = 0,186) za pojavu metastaza u regionalnim limfnim čvorovima. Relativni rizik [exp (B)] od pojave metastaze u regionalnim limfnim čvorovima u odnosu na veličinu tumora iznosio je 2,807. Zaključak. Histološki i nuklearni gradusi tumora nisu prognostički faktori pojave recidiva i metastatske bolesti PCC usne. Veličina tumora predstavlja prognostički faktor za pojavu recidiva i regionalnih metastaza PCC usne, tj. faktor koji omogućava podelu bolesnika sa karcinomom usne u grupu sa većim, odnosno manjim rizikom od pojave recidiva i/ili metastatske bolesti. Prema našim rezultatima, sa povećanjem veličine PCC usne iznad 2 cm rizik od pojave regionalnih metastaza povećava se 2,8 puta.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma, Povezanost histopatoloških karakteristika karcinoma usne sa progresijom bolesti",
volume = "67",
number = "1",
pages = "19-24",
doi = "10.2298/VSP1001019G"
}

Golubović, M., Ašanin, B., Jelovac, D., Petrović, M.,& Antunović, M.. (2010). Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 67(1), 19-24.
https://doi.org/10.2298/VSP1001019G

Golubović M, Ašanin B, Jelovac D, Petrović M, Antunović M. Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma. in Vojnosanitetski pregled. 2010;67(1):19-24.
doi:10.2298/VSP1001019G .

Golubović, Mileta, Ašanin, Bogdan, Jelovac, Drago, Petrović, Milan, Antunović, Marija, "Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma" in Vojnosanitetski pregled, 67, no. 1 (2010):19-24,
https://doi.org/10.2298/VSP1001019G . .

TY  - JOUR
AU  - Petrović, Milan
AU  - Jelovac, Drago
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1377
AB  - Aim: Lip cancer is one of the most common cancers of the head and neck region. Among all lip malignancies, squamous cell carcinoma is most common, whereas basal cell carcinoma accounts for only 1% of all lip carcinomas. The aim of this paper was to evaluate the frequency of lip lesions among Serbian population and to consider its outcome. Material and Method: The analysis encompassed 479 patients who were hospitalized at the Clinic of Maxillofacial Surgery (Faculty of Dentistry, University of Belgrade) during the period 1989-2005 for the treatment of lip lesions. The following parameters were analyzed: sex, age, size and localization of the lesion, duration of hospitalization, TNM classification, histopathologic analysis, type of surgical procedure, other possible treatment, and a recurrence rate. Results: There were majority of males (78%). Average age of our patients was 63.4 years. Lesions were most often localized in the lower lip (88%), and less frequently in the upper lip (8%) or at the lip angle (4%). Average size of the lesion was 24.3 mm. Data confirmed that the 'W' excision was the most frequently used surgical procedure, and for bigger lesions, surgical reconstruction was performed by the technique suggested by Karapandzic. Histopathologic analysis confirmed the most frequent incidence of the squamous cell carcinoma. Conclusion: Squamous cell carcinoma of the lip generally has a favourable prognosis. Early detection is very important for its successful treatment.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Stomatology
T1  - The frequency and outcome of lip cancer in Serbian population
VL  - 12
IS  - 1
SP  - 34
EP  - 37
UR  - https://hdl.handle.net/21.15107/rcub_smile_1377
ER  - 

@article{
author = "Petrović, Milan and Jelovac, Drago",
year = "2008",
abstract = "Aim: Lip cancer is one of the most common cancers of the head and neck region. Among all lip malignancies, squamous cell carcinoma is most common, whereas basal cell carcinoma accounts for only 1% of all lip carcinomas. The aim of this paper was to evaluate the frequency of lip lesions among Serbian population and to consider its outcome. Material and Method: The analysis encompassed 479 patients who were hospitalized at the Clinic of Maxillofacial Surgery (Faculty of Dentistry, University of Belgrade) during the period 1989-2005 for the treatment of lip lesions. The following parameters were analyzed: sex, age, size and localization of the lesion, duration of hospitalization, TNM classification, histopathologic analysis, type of surgical procedure, other possible treatment, and a recurrence rate. Results: There were majority of males (78%). Average age of our patients was 63.4 years. Lesions were most often localized in the lower lip (88%), and less frequently in the upper lip (8%) or at the lip angle (4%). Average size of the lesion was 24.3 mm. Data confirmed that the 'W' excision was the most frequently used surgical procedure, and for bigger lesions, surgical reconstruction was performed by the technique suggested by Karapandzic. Histopathologic analysis confirmed the most frequent incidence of the squamous cell carcinoma. Conclusion: Squamous cell carcinoma of the lip generally has a favourable prognosis. Early detection is very important for its successful treatment.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Stomatology",
title = "The frequency and outcome of lip cancer in Serbian population",
volume = "12",
number = "1",
pages = "34-37",
url = "https://hdl.handle.net/21.15107/rcub_smile_1377"
}

Petrović, M.,& Jelovac, D.. (2008). The frequency and outcome of lip cancer in Serbian population. in Balkan Journal of Stomatology
Udruženje stomatologa Balkana., 12(1), 34-37.
https://hdl.handle.net/21.15107/rcub_smile_1377

Petrović M, Jelovac D. The frequency and outcome of lip cancer in Serbian population. in Balkan Journal of Stomatology. 2008;12(1):34-37.
https://hdl.handle.net/21.15107/rcub_smile_1377 .

Petrović, Milan, Jelovac, Drago, "The frequency and outcome of lip cancer in Serbian population" in Balkan Journal of Stomatology, 12, no. 1 (2008):34-37,
https://hdl.handle.net/21.15107/rcub_smile_1377 .

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Petrović, Milan
AU  - Medenica, Ljiljana M.
AU  - Lens, Marko
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1347
AB  - Background: The most common type of lip carcinoma is squamous cell carcinoma (SCC), accounting for approximately 90% of all oral malignancies. Currently, surgery and/or radiotherapy are considered the standards of care for SCC of the lip. Materials and Methods: We retrospectively analyzed medical records of patients diagnosed with SCC of the lip at the Clinic for Maxillofacial surgery at University of Belgrade (Belgrade, Serbia) during a period between 1991 and 2000. Results: A total of 223 patients with SCC of the lip were diagnosed and treated during a 10-year period. The overall male-to-female ratio was 5 to 0. The most frequently affected site was the lower lip (92.8%,). Mean diameter of the tumor was 30.1 mm (range, 5 to 80 full Neck lymph node metastases at presentation was detected in 26.5% of patients, who subsequently underwent neck dissection. We observed a linear trend in the association between the size of the tumor and the clinical stage of the neck (chi(2) = 15.1; df = 1; P  lt  .0001). Different surgical techniques were used for reconstruction of the lip defect after tumor removal. After a median follow-up of 56 months (range, 15 to 78 months), local recurrence occurred in 10.8% of patients while regional metastases developed in 4.5% of patients. Mortality from SCC of the lip was only 2.2%. Conclusion: SCC of the lip generally has a favorable outcome. Recently, there have been no major advances in lip reconstruction but rather continued improvement on accepted techniques. Early detection is essential for the successful treatment of SCC of the lip, which requires a multidisciplinary approach.
PB  - W B Saunders Co-Elsevier Inc, Philadelphia
T2  - Journal of Oral & Maxillofacial Surgery
T1  - Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients
VL  - 65
IS  - 4
SP  - 675
EP  - 679
DO  - 10.1016/j.joms.2006.03.054
ER  - 

@article{
author = "Vukadinović, Miroslav and Jezdić, Zoran and Petrović, Milan and Medenica, Ljiljana M. and Lens, Marko",
year = "2007",
abstract = "Background: The most common type of lip carcinoma is squamous cell carcinoma (SCC), accounting for approximately 90% of all oral malignancies. Currently, surgery and/or radiotherapy are considered the standards of care for SCC of the lip. Materials and Methods: We retrospectively analyzed medical records of patients diagnosed with SCC of the lip at the Clinic for Maxillofacial surgery at University of Belgrade (Belgrade, Serbia) during a period between 1991 and 2000. Results: A total of 223 patients with SCC of the lip were diagnosed and treated during a 10-year period. The overall male-to-female ratio was 5 to 0. The most frequently affected site was the lower lip (92.8%,). Mean diameter of the tumor was 30.1 mm (range, 5 to 80 full Neck lymph node metastases at presentation was detected in 26.5% of patients, who subsequently underwent neck dissection. We observed a linear trend in the association between the size of the tumor and the clinical stage of the neck (chi(2) = 15.1; df = 1; P  lt  .0001). Different surgical techniques were used for reconstruction of the lip defect after tumor removal. After a median follow-up of 56 months (range, 15 to 78 months), local recurrence occurred in 10.8% of patients while regional metastases developed in 4.5% of patients. Mortality from SCC of the lip was only 2.2%. Conclusion: SCC of the lip generally has a favorable outcome. Recently, there have been no major advances in lip reconstruction but rather continued improvement on accepted techniques. Early detection is essential for the successful treatment of SCC of the lip, which requires a multidisciplinary approach.",
publisher = "W B Saunders Co-Elsevier Inc, Philadelphia",
journal = "Journal of Oral & Maxillofacial Surgery",
title = "Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients",
volume = "65",
number = "4",
pages = "675-679",
doi = "10.1016/j.joms.2006.03.054"
}

Vukadinović, M., Jezdić, Z., Petrović, M., Medenica, L. M.,& Lens, M.. (2007). Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients. in Journal of Oral & Maxillofacial Surgery
W B Saunders Co-Elsevier Inc, Philadelphia., 65(4), 675-679.
https://doi.org/10.1016/j.joms.2006.03.054

Vukadinović M, Jezdić Z, Petrović M, Medenica LM, Lens M. Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients. in Journal of Oral & Maxillofacial Surgery. 2007;65(4):675-679.
doi:10.1016/j.joms.2006.03.054 .

Vukadinović, Miroslav, Jezdić, Zoran, Petrović, Milan, Medenica, Ljiljana M., Lens, Marko, "Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients" in Journal of Oral & Maxillofacial Surgery, 65, no. 4 (2007):675-679,
https://doi.org/10.1016/j.joms.2006.03.054 . .

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Petrović, Milan
AU  - Jezdić, Zoran
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1270
AB  - Background/aim: Lip carcinoma makes about 1/4 of all oral carcinomas. Primary treatment of the lower lip carcinoma means radical excision of the full thickness of the lower lip tissue together with the tumor. The reconstruction of the defect accomplished after the removal of the lower lip tumor is a challenge for the surgeon and requires a detailed preoperative planning, the right choice of the method for reconstruction and the knowledge of the adequate surgical techniques needed. The aim of this study was to present a ten-year clinical results and experience concerning the reconstruction of lower lip defects longer than 4 cm by means of the modified Fries method in patients treated for the lower lip carcinoma. Methods. The reconstruction of the lower lip by means of the modified Fries method was performed in 37 patients. The following parameters were analyzed: sex, age, the time elapsed from the occurrence of the first symptoms until the first consultation with the doctor, the size of tumors, the size of the postexcision defect, TNM classification, the application of side diagnostic procedures, pathohistological diagnosis of postoperative complications. The sensibility of the lower lip region was monitored, as well as the obtained esthetic effects. Results. The results classified according to the mentioned parameters were processed, analyzed and displayed in detail. Clinical experience concerning the application of this reconstruction technique was presented and analyzed. Conclusion. The modified Fries technique can successfully be applied in the reconstruction of the lower lip defects longer than 4 cm because its application leads to satisfactory functional and acceptable esthetic results.
AB  - Uvod/cilj: Karcinomi usana čine približno oko 1/4 svih karcinoma usne duplje. Primarno lečenje karcinoma donje usne podrazumeva radikalnu eksciziju pune debljine tkiva donje usne zajedno sa tumorom. Nadoknada defekta nastalog nakon uklanjanja tumora donje usne predstavlja izazov za hirurga i zahteva detaljno preoperativno planiranje, pravilan izbor načina rekonstrukcije i poznavanje odgovarajućih hirurških tehnika. Cilj rada je da se kroz desetogodišnju retrospektivnu studiju prikažu naši klinički rezultati i iskustva u nadoknadi velikih defekata donje usne modifikovanom metodom po Friesu kod bolesnika lečenih od karcinoma donje usne. Metode. Od 256 bolesnika lečenih zbog tumora donje usne u periodu od 1992. do 2001. godine, kod 37 je primenjena rekonstrukcija modifikovanom metodom po Friesu. Analizirani su sledeći parametri: pol i godine starosti bolesnika, vreme proteklo od pojave prvih simptoma do javljanja lekaru, veličina tumora, veličina postekscizionog defekta, TNM klasifikacija, primena pomoćnih dijagnostičkih procedura, patohistološka dijagnoza, postoperativne komplikacije. Beležena su opažanja bolesnika u vezi senzibiliteta predela donje usne. Procenjivani su i ostvareni estetski efekti. Rezultati. Detaljno su obrađeni, analizirani i prikazani rezultati po navedenim parametrima. Izneta su naša klinička iskustva u primeni ove tehnike rekonstrukcije. Analizirane su njene prednosti i mane. Zaključak. Modifikovana tehnika po Friesu može se uspešno primeniti u rekonstrukciji defekata donje usne većih od 4 cm do potpunog nedostatka donje usne, jer se njenom primenom ostvaruju zadovoljavajući funkcionalni i prihvatljivi estetski rezultati.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor
T1  - Primena modifikovane metode po Friesu u rekonstrukciji donje usne posle uklanjanja malignih tumora
VL  - 63
IS  - 9
SP  - 801
EP  - 806
DO  - 10.2298/VSP0609801V
ER  - 

@article{
author = "Vukadinović, Miroslav and Petrović, Milan and Jezdić, Zoran",
year = "2006",
abstract = "Background/aim: Lip carcinoma makes about 1/4 of all oral carcinomas. Primary treatment of the lower lip carcinoma means radical excision of the full thickness of the lower lip tissue together with the tumor. The reconstruction of the defect accomplished after the removal of the lower lip tumor is a challenge for the surgeon and requires a detailed preoperative planning, the right choice of the method for reconstruction and the knowledge of the adequate surgical techniques needed. The aim of this study was to present a ten-year clinical results and experience concerning the reconstruction of lower lip defects longer than 4 cm by means of the modified Fries method in patients treated for the lower lip carcinoma. Methods. The reconstruction of the lower lip by means of the modified Fries method was performed in 37 patients. The following parameters were analyzed: sex, age, the time elapsed from the occurrence of the first symptoms until the first consultation with the doctor, the size of tumors, the size of the postexcision defect, TNM classification, the application of side diagnostic procedures, pathohistological diagnosis of postoperative complications. The sensibility of the lower lip region was monitored, as well as the obtained esthetic effects. Results. The results classified according to the mentioned parameters were processed, analyzed and displayed in detail. Clinical experience concerning the application of this reconstruction technique was presented and analyzed. Conclusion. The modified Fries technique can successfully be applied in the reconstruction of the lower lip defects longer than 4 cm because its application leads to satisfactory functional and acceptable esthetic results., Uvod/cilj: Karcinomi usana čine približno oko 1/4 svih karcinoma usne duplje. Primarno lečenje karcinoma donje usne podrazumeva radikalnu eksciziju pune debljine tkiva donje usne zajedno sa tumorom. Nadoknada defekta nastalog nakon uklanjanja tumora donje usne predstavlja izazov za hirurga i zahteva detaljno preoperativno planiranje, pravilan izbor načina rekonstrukcije i poznavanje odgovarajućih hirurških tehnika. Cilj rada je da se kroz desetogodišnju retrospektivnu studiju prikažu naši klinički rezultati i iskustva u nadoknadi velikih defekata donje usne modifikovanom metodom po Friesu kod bolesnika lečenih od karcinoma donje usne. Metode. Od 256 bolesnika lečenih zbog tumora donje usne u periodu od 1992. do 2001. godine, kod 37 je primenjena rekonstrukcija modifikovanom metodom po Friesu. Analizirani su sledeći parametri: pol i godine starosti bolesnika, vreme proteklo od pojave prvih simptoma do javljanja lekaru, veličina tumora, veličina postekscizionog defekta, TNM klasifikacija, primena pomoćnih dijagnostičkih procedura, patohistološka dijagnoza, postoperativne komplikacije. Beležena su opažanja bolesnika u vezi senzibiliteta predela donje usne. Procenjivani su i ostvareni estetski efekti. Rezultati. Detaljno su obrađeni, analizirani i prikazani rezultati po navedenim parametrima. Izneta su naša klinička iskustva u primeni ove tehnike rekonstrukcije. Analizirane su njene prednosti i mane. Zaključak. Modifikovana tehnika po Friesu može se uspešno primeniti u rekonstrukciji defekata donje usne većih od 4 cm do potpunog nedostatka donje usne, jer se njenom primenom ostvaruju zadovoljavajući funkcionalni i prihvatljivi estetski rezultati.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor, Primena modifikovane metode po Friesu u rekonstrukciji donje usne posle uklanjanja malignih tumora",
volume = "63",
number = "9",
pages = "801-806",
doi = "10.2298/VSP0609801V"
}

Vukadinović, M., Petrović, M.,& Jezdić, Z.. (2006). Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 63(9), 801-806.
https://doi.org/10.2298/VSP0609801V

Vukadinović M, Petrović M, Jezdić Z. Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor. in Vojnosanitetski pregled. 2006;63(9):801-806.
doi:10.2298/VSP0609801V .

Vukadinović, Miroslav, Petrović, Milan, Jezdić, Zoran, "Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor" in Vojnosanitetski pregled, 63, no. 9 (2006):801-806,
https://doi.org/10.2298/VSP0609801V . .

TY  - JOUR
AU  - Petrović, Milan
AU  - Dodić, Slobodan
PY  - 2000
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1112
AB  - Every occlusal therapy comprises an analysis, detection and removal of occlusal disorders as well as dental restoration. In this paper are presented different occlusal indicators (markers) which are now available on the market and their advantages and disadvantages are described.
AB  - Analiza okluzije, otkrivanje i otklanjanje okluzalnih smetnji, kao i izrada zubnih nadoknada su sastavni deo svake okluzalne terapije. Ovi postupci se ne mogu izvesti uspešno bez odgovarajućih okluzalnih indikatora. U radu su nabrojani različiti indikatori (markeri) trenutno dostupni na tržištu i opisane njihove prednosti i nedostatci.
PB  - Udruženje stomatologa Srbije i Crne Gore - Sekcija za stomatološku protetiku, Beograd
T2  - Stomatološka protetika
T1  - Methods (techniques) for registration of occlusal contacts
T1  - Metodi (tehnike) za registrovanje okluzalnih kontakata
VL  - 2
IS  - 1
SP  - 31
EP  - 35
UR  - https://hdl.handle.net/21.15107/rcub_smile_1112
ER  - 

@article{
author = "Petrović, Milan and Dodić, Slobodan",
year = "2000",
abstract = "Every occlusal therapy comprises an analysis, detection and removal of occlusal disorders as well as dental restoration. In this paper are presented different occlusal indicators (markers) which are now available on the market and their advantages and disadvantages are described., Analiza okluzije, otkrivanje i otklanjanje okluzalnih smetnji, kao i izrada zubnih nadoknada su sastavni deo svake okluzalne terapije. Ovi postupci se ne mogu izvesti uspešno bez odgovarajućih okluzalnih indikatora. U radu su nabrojani različiti indikatori (markeri) trenutno dostupni na tržištu i opisane njihove prednosti i nedostatci.",
publisher = "Udruženje stomatologa Srbije i Crne Gore - Sekcija za stomatološku protetiku, Beograd",
journal = "Stomatološka protetika",
title = "Methods (techniques) for registration of occlusal contacts, Metodi (tehnike) za registrovanje okluzalnih kontakata",
volume = "2",
number = "1",
pages = "31-35",
url = "https://hdl.handle.net/21.15107/rcub_smile_1112"
}

Petrović, M.,& Dodić, S.. (2000). Methods (techniques) for registration of occlusal contacts. in Stomatološka protetika
Udruženje stomatologa Srbije i Crne Gore - Sekcija za stomatološku protetiku, Beograd., 2(1), 31-35.
https://hdl.handle.net/21.15107/rcub_smile_1112

Petrović M, Dodić S. Methods (techniques) for registration of occlusal contacts. in Stomatološka protetika. 2000;2(1):31-35.
https://hdl.handle.net/21.15107/rcub_smile_1112 .

Petrović, Milan, Dodić, Slobodan, "Methods (techniques) for registration of occlusal contacts" in Stomatološka protetika, 2, no. 1 (2000):31-35,
https://hdl.handle.net/21.15107/rcub_smile_1112 .