TY  - JOUR
AU  - Zorić, Bojana
AU  - Janković, Ljiljana
AU  - Kuzmanović-Pfićer, Jovana
AU  - Zidverc-Trajković, Jasna
AU  - Mijajlović, Milija
AU  - Stanimirović, Dragan
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2288
AB  - Background: Burning mouth syndrome (BMS) is an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than 3 months. The objective was to evaluate and analyse the efficacy of serotonin reuptake inhibitor fluoxetine on psychological factors, as well as on pain in participants with BMS. Methods: In a 6-month study, 100 participants with primary and secondary BMS were divided into two groups-fluoxetine and control (placebo) and examined by the dentist and the neurologist. Depression and anxiety were estimated by Hamilton Scale for Depression (HAM-D) and Anxiety (HAM-A) and Beck Depression Inventory (BDI) and the pain intensity by visual analogue scale (VAS). Results: Mean age of the participants was 60.33 in fluoxetine group and 67.4 in control group. Most of the participants were female-74% in the fluoxetine and 78% in the control group. Statistical difference between the fluoxetine and the control group was found in HAM-D results (P  lt  .05). Values of other scales and VAS decreased significantly after the therapy in both groups (P  lt  .05). Conclusions: Our trial results indicate that fluoxetine therapy not only improves the psychological status of participants with BMS but also fluoxetine decreases the intensity of pain in these patients.
PB  - Wiley, Hoboken
T2  - Gerodontology
T1  - The efficacy of fluoxetine in BMS-A cross-over study
VL  - 35
IS  - 2
SP  - 123
EP  - 128
DO  - 10.1111/ger.12332
ER  - 

@article{
author = "Zorić, Bojana and Janković, Ljiljana and Kuzmanović-Pfićer, Jovana and Zidverc-Trajković, Jasna and Mijajlović, Milija and Stanimirović, Dragan",
year = "2018",
abstract = "Background: Burning mouth syndrome (BMS) is an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than 3 months. The objective was to evaluate and analyse the efficacy of serotonin reuptake inhibitor fluoxetine on psychological factors, as well as on pain in participants with BMS. Methods: In a 6-month study, 100 participants with primary and secondary BMS were divided into two groups-fluoxetine and control (placebo) and examined by the dentist and the neurologist. Depression and anxiety were estimated by Hamilton Scale for Depression (HAM-D) and Anxiety (HAM-A) and Beck Depression Inventory (BDI) and the pain intensity by visual analogue scale (VAS). Results: Mean age of the participants was 60.33 in fluoxetine group and 67.4 in control group. Most of the participants were female-74% in the fluoxetine and 78% in the control group. Statistical difference between the fluoxetine and the control group was found in HAM-D results (P  lt  .05). Values of other scales and VAS decreased significantly after the therapy in both groups (P  lt  .05). Conclusions: Our trial results indicate that fluoxetine therapy not only improves the psychological status of participants with BMS but also fluoxetine decreases the intensity of pain in these patients.",
publisher = "Wiley, Hoboken",
journal = "Gerodontology",
title = "The efficacy of fluoxetine in BMS-A cross-over study",
volume = "35",
number = "2",
pages = "123-128",
doi = "10.1111/ger.12332"
}

Zorić, B., Janković, L., Kuzmanović-Pfićer, J., Zidverc-Trajković, J., Mijajlović, M.,& Stanimirović, D.. (2018). The efficacy of fluoxetine in BMS-A cross-over study. in Gerodontology
Wiley, Hoboken., 35(2), 123-128.
https://doi.org/10.1111/ger.12332

Zorić B, Janković L, Kuzmanović-Pfićer J, Zidverc-Trajković J, Mijajlović M, Stanimirović D. The efficacy of fluoxetine in BMS-A cross-over study. in Gerodontology. 2018;35(2):123-128.
doi:10.1111/ger.12332 .

Zorić, Bojana, Janković, Ljiljana, Kuzmanović-Pfićer, Jovana, Zidverc-Trajković, Jasna, Mijajlović, Milija, Stanimirović, Dragan, "The efficacy of fluoxetine in BMS-A cross-over study" in Gerodontology, 35, no. 2 (2018):123-128,
https://doi.org/10.1111/ger.12332 . .

TY  - THES
AU  - Zorić, Bojana
PY  - 2018
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=6563
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:19337/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=50909455
UR  - http://nardus.mpn.gov.rs/123456789/10718
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1033
AB  - Affective disorders, particularly depression, are frequent comorbidities in patients with primary Burning mouth syndrome (pBMS). Brainstem raphe (BR) represents main source of serotonin and it is assumed that it´s deficiency can cause pBMS symptoms. Studies with transcranial parenchymal sonography (TCS) determined the presence of BR hypoehogenicity in 50-70% of patients with unipolar depression which is linked with responsivity to serotonin-reuptake inhibitors (SSRI). The latter supports the hypothesis that raphe hypoehogenicity can be a marker of damaged serotonin central transmission. Etiology of pBMS, also, refers to the changes in dopamine nigrostraital pathway that starts in substantia nigra (SN) toward basal ganglia (corpus striatum). BMS manifests with chronic intraoral burning sensations and represents an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than three months without any pathological changes of oral mucosa. BMS is more frequent in women, mostly middle aged and elderly, and it can be divided into primary and secondary form. Etiology of secondary BMS (sBMS) can be local and systemic. The onset of the pBMS is related to BR hypoechogenicity which can be noticed in patients with unipolar depression and depression in Parkinson disease. Objective: The aims of this study were to evaluate clinical characterstics of BMS, neurological and psychological status of patients with elimination of local and systemic etiological factors. Additionally, aim was to determine connection between raphe and substantia nigra echogenicity and clinical and affective status of patients. Also, this study had objective to define therapy efficiency. Methods: The study included 70 patients with complaint of oral burning sensation, from which 30 patients were included into the research after taking anamnesis, clinical examination and supplementary tests. Echogenicity of BR and SN was determined with TCS examination. Medication fluoxetine from the SSRI group was prescribed to all patients. Control examinations were conducted after 3 and 6 months...
AB  - Afektivni poremećaji, pogotovo depresija, su česti komorbiditeti kod pacijenata sa primarnim Sindromom pekućeg bola usne duplje (pSPU). Jedra rafe (RM) predstavljaju glavni izvor serotonina u mozgu i smatra se da njegov nedostatak može izazvati simptome pSPU. Ispitivanja sa primenom transkranijalne parenhimske sonografije (TCS) su utvrdila hipoehogenost struktura RM kod 50-70% pacijenata sa unipolarnom depresijom koja je povezana sa odgovorom na inhibitore preuzimanja serotonina, što podržava hipotezu da hipoehogenost RM može biti marker oštećene centralne transmisije serotonina. Takođe se u etiologiji pSPU govori o izmenjenom dopaminergičkom nigrostrijatnom putu, koji polazi iz supstancije nigre (SN) ka bazalnim ganglijama (corpus striatum-u). SPU se manifestuje hroničnim osećajem peckanja i žarenja u usnoj dupllji i predstavlja osećaj pečenja u ustima i dizestezije koje se ponavljaju tokom dana, više od 2 sata i duže od 3 meseca, bez klinički evidentnih lezija. Pojava ovog oboljenja češća je kod osoba ženskog pola, srednje i starije životne dobi. Ovaj Sindrom može biti primarni i sekundarni. Etiologija sekundarnog SPU može biti lokalna i sistemska. Nastanak pSPU se dovodi u vezu sa sniženom ehogenosti jedara rafe, koje je prisutna i kod pacijenata sa unipolarnom depresijom i depresijom udruženom sa Parkinsonovom bolesti. Cilj: Cilj ovog istraživanja je bio da se evaluiraju kliničke karakteristike SPU, neurološki i psihološki profil pacijenata, uz eliminaciju lokalnih i sistemskih etioloških faktora. Dodatno, cilj je bio utvrđivanje povezanosti ehogenosti jedara rafe i SN sa kliničkim i afektivnim statusom pacijenata. Takođe, istraživanje je imalo za cilj procenu efikasnosti primenjene terapije. Materijal i metode: Istraživanjem je obuhvaćeno 70 pacijenata sa simptomima SPU, od kojih je nakon anamneze, kliničkog pregleda i dopunskih ispitivanja, u studiju uključeno njih 30. Ehogenost RM i SN je procenjivana upotrebom TCS. Svim pacijentima je ordiniran lek fluoksetin iz grupe selektivnih inhibitora preuzimanja serotonina. Kontrolni pregledi su se obavljali nakon 3 i 6 meseci...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Affective disorders and brainstem raphe and substantia nigra echogenicity in evaluation of Burning mouth syndrome therapy efficiency
T1  - Afektivni status i ehogenost jedara rafe i supstancije nigre u proceni efikasnosti terapije Sindroma pekućeg bola usne duplje
UR  - https://hdl.handle.net/21.15107/rcub_nardus_10718
ER  - 

@phdthesis{
author = "Zorić, Bojana",
year = "2018",
abstract = "Affective disorders, particularly depression, are frequent comorbidities in patients with primary Burning mouth syndrome (pBMS). Brainstem raphe (BR) represents main source of serotonin and it is assumed that it´s deficiency can cause pBMS symptoms. Studies with transcranial parenchymal sonography (TCS) determined the presence of BR hypoehogenicity in 50-70% of patients with unipolar depression which is linked with responsivity to serotonin-reuptake inhibitors (SSRI). The latter supports the hypothesis that raphe hypoehogenicity can be a marker of damaged serotonin central transmission. Etiology of pBMS, also, refers to the changes in dopamine nigrostraital pathway that starts in substantia nigra (SN) toward basal ganglia (corpus striatum). BMS manifests with chronic intraoral burning sensations and represents an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than three months without any pathological changes of oral mucosa. BMS is more frequent in women, mostly middle aged and elderly, and it can be divided into primary and secondary form. Etiology of secondary BMS (sBMS) can be local and systemic. The onset of the pBMS is related to BR hypoechogenicity which can be noticed in patients with unipolar depression and depression in Parkinson disease. Objective: The aims of this study were to evaluate clinical characterstics of BMS, neurological and psychological status of patients with elimination of local and systemic etiological factors. Additionally, aim was to determine connection between raphe and substantia nigra echogenicity and clinical and affective status of patients. Also, this study had objective to define therapy efficiency. Methods: The study included 70 patients with complaint of oral burning sensation, from which 30 patients were included into the research after taking anamnesis, clinical examination and supplementary tests. Echogenicity of BR and SN was determined with TCS examination. Medication fluoxetine from the SSRI group was prescribed to all patients. Control examinations were conducted after 3 and 6 months..., Afektivni poremećaji, pogotovo depresija, su česti komorbiditeti kod pacijenata sa primarnim Sindromom pekućeg bola usne duplje (pSPU). Jedra rafe (RM) predstavljaju glavni izvor serotonina u mozgu i smatra se da njegov nedostatak može izazvati simptome pSPU. Ispitivanja sa primenom transkranijalne parenhimske sonografije (TCS) su utvrdila hipoehogenost struktura RM kod 50-70% pacijenata sa unipolarnom depresijom koja je povezana sa odgovorom na inhibitore preuzimanja serotonina, što podržava hipotezu da hipoehogenost RM može biti marker oštećene centralne transmisije serotonina. Takođe se u etiologiji pSPU govori o izmenjenom dopaminergičkom nigrostrijatnom putu, koji polazi iz supstancije nigre (SN) ka bazalnim ganglijama (corpus striatum-u). SPU se manifestuje hroničnim osećajem peckanja i žarenja u usnoj dupllji i predstavlja osećaj pečenja u ustima i dizestezije koje se ponavljaju tokom dana, više od 2 sata i duže od 3 meseca, bez klinički evidentnih lezija. Pojava ovog oboljenja češća je kod osoba ženskog pola, srednje i starije životne dobi. Ovaj Sindrom može biti primarni i sekundarni. Etiologija sekundarnog SPU može biti lokalna i sistemska. Nastanak pSPU se dovodi u vezu sa sniženom ehogenosti jedara rafe, koje je prisutna i kod pacijenata sa unipolarnom depresijom i depresijom udruženom sa Parkinsonovom bolesti. Cilj: Cilj ovog istraživanja je bio da se evaluiraju kliničke karakteristike SPU, neurološki i psihološki profil pacijenata, uz eliminaciju lokalnih i sistemskih etioloških faktora. Dodatno, cilj je bio utvrđivanje povezanosti ehogenosti jedara rafe i SN sa kliničkim i afektivnim statusom pacijenata. Takođe, istraživanje je imalo za cilj procenu efikasnosti primenjene terapije. Materijal i metode: Istraživanjem je obuhvaćeno 70 pacijenata sa simptomima SPU, od kojih je nakon anamneze, kliničkog pregleda i dopunskih ispitivanja, u studiju uključeno njih 30. Ehogenost RM i SN je procenjivana upotrebom TCS. Svim pacijentima je ordiniran lek fluoksetin iz grupe selektivnih inhibitora preuzimanja serotonina. Kontrolni pregledi su se obavljali nakon 3 i 6 meseci...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Affective disorders and brainstem raphe and substantia nigra echogenicity in evaluation of Burning mouth syndrome therapy efficiency, Afektivni status i ehogenost jedara rafe i supstancije nigre u proceni efikasnosti terapije Sindroma pekućeg bola usne duplje",
url = "https://hdl.handle.net/21.15107/rcub_nardus_10718"
}

Zorić, B.. (2018). Affective disorders and brainstem raphe and substantia nigra echogenicity in evaluation of Burning mouth syndrome therapy efficiency. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_10718

Zorić B. Affective disorders and brainstem raphe and substantia nigra echogenicity in evaluation of Burning mouth syndrome therapy efficiency. 2018;.
https://hdl.handle.net/21.15107/rcub_nardus_10718 .

Zorić, Bojana, "Affective disorders and brainstem raphe and substantia nigra echogenicity in evaluation of Burning mouth syndrome therapy efficiency" (2018),
https://hdl.handle.net/21.15107/rcub_nardus_10718 .

TY  - THES
AU  - Zorić, Bojana
PY  - 2017
UR  - https://plus.sr.cobiss.net/opac7/bib/1024293262
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/756
AB  - Poznato je da pljuvačka ima sprecifičnu ulogu u održavanju oralnog zdravlja, te da ima mnogo uloga i funkcija u održavanju normalnog oralnog ekosistema, održava fiziološke vrednosti Ph, održava integritet čvrstih i mekih tkiva oralne sredine. Sekret pljuvačke ima značajnu antimikrobnu zaštitu oralnih tkiva.  
Pljuvačka oblaže mukozu i pomaže u zaštiti od mehaničkih, termičkih i hemijskih iritacija, te u nesmetanom protoku vazduha, govoru i gutanju. Ova njena funkcija označava se kao lubrikantna. 
Saliva je prezasićena jonima kalcijuma i fosfata, pa predstavlja rezervoar jona koji omogućavaju remineralizaciju zuba.
Antimikrobni proteini pljuvačke predstavljaju glavne faktore nespecifične humoralne antimikrobne zaštite oralne sredine. Najznačajniji antimikrobni proteini pljuvačke su: histatini, defenzini, lakoferin, katelicidini, mucini, kalprotektin, lizozim kao i oralna peroksidaza.
Navedeni sastojci pljuvačke sprečavaju kolonizaciju oralne mukoze patogenim mikroorganizmima i održavaju normalne oralne bakterijske flore imaju i značaj u održavanju opšteg zdravlja organizma jer sprečavaju transmisiju patogena u unutrašnju sredinu domaćina.
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Antimikrobni peptidi pljuvačke
UR  - https://hdl.handle.net/21.15107/rcub_smile_756
ER  - 

@misc{
author = "Zorić, Bojana",
year = "2017",
abstract = "Poznato je da pljuvačka ima sprecifičnu ulogu u održavanju oralnog zdravlja, te da ima mnogo uloga i funkcija u održavanju normalnog oralnog ekosistema, održava fiziološke vrednosti Ph, održava integritet čvrstih i mekih tkiva oralne sredine. Sekret pljuvačke ima značajnu antimikrobnu zaštitu oralnih tkiva.  
Pljuvačka oblaže mukozu i pomaže u zaštiti od mehaničkih, termičkih i hemijskih iritacija, te u nesmetanom protoku vazduha, govoru i gutanju. Ova njena funkcija označava se kao lubrikantna. 
Saliva je prezasićena jonima kalcijuma i fosfata, pa predstavlja rezervoar jona koji omogućavaju remineralizaciju zuba.
Antimikrobni proteini pljuvačke predstavljaju glavne faktore nespecifične humoralne antimikrobne zaštite oralne sredine. Najznačajniji antimikrobni proteini pljuvačke su: histatini, defenzini, lakoferin, katelicidini, mucini, kalprotektin, lizozim kao i oralna peroksidaza.
Navedeni sastojci pljuvačke sprečavaju kolonizaciju oralne mukoze patogenim mikroorganizmima i održavaju normalne oralne bakterijske flore imaju i značaj u održavanju opšteg zdravlja organizma jer sprečavaju transmisiju patogena u unutrašnju sredinu domaćina.",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Antimikrobni peptidi pljuvačke",
url = "https://hdl.handle.net/21.15107/rcub_smile_756"
}

Zorić, B.. (2017). Antimikrobni peptidi pljuvačke. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_756

Zorić B. Antimikrobni peptidi pljuvačke. 2017;.
https://hdl.handle.net/21.15107/rcub_smile_756 .

Zorić, Bojana, "Antimikrobni peptidi pljuvačke" (2017),
https://hdl.handle.net/21.15107/rcub_smile_756 .