TY  - JOUR
AU  - Janović, Aleksa
AU  - Milovanović, Petar
AU  - Sopta, Jelena
AU  - Rakočević, Zoran
AU  - Filipović, Vojislav
AU  - Nenezić, Dragoslav
AU  - Đurić, Marija
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3296
AB  - Endocranial bone lesions have attracted intensive scientific debate on their aetiology. In recent literature, the lesions were almost exclusively interpreted as of infectious origin. In this paper, we give new insight into the aetiology of endocranial lesions, distinguishing the lesions of vascular origin from those caused by tuberculosis or other conditions. The analysis is based on a rare case of a young female individual who displayed multiple endocranial lesions with ‘serpens endocrania symmetrica’ morphology. The lesions were associated with an uncommon branching pattern of the middle meningeal artery and marked side differences in teeth pathology. Postcranial skeleton showed signs of the left upper limb weakness. The macroscopic finding of the endocranial lesions along with the skeletal evidence of neurological damage, together with characteristic radiological and histological features, can lead to diagnosis of arteriovenous malformations. This study aims to improve understanding of the aetiology of endocranial bone lesions.
PB  - Wiley-Blackwell, Hoboken
T2  - International Journal of Osteoarchaeology
T1  - Intracranial Arteriovenous Malformations as a Possible Cause of Endocranial Bone Lesions and Associated Neurological Disorder
VL  - 25
IS  - 1
SP  - 88
EP  - 97
DO  - https://doi.org/10.1002/oa.2266
ER  - 

@article{
author = "Janović, Aleksa and Milovanović, Petar and Sopta, Jelena and Rakočević, Zoran and Filipović, Vojislav and Nenezić, Dragoslav and Đurić, Marija",
year = "2015",
abstract = "Endocranial bone lesions have attracted intensive scientific debate on their aetiology. In recent literature, the lesions were almost exclusively interpreted as of infectious origin. In this paper, we give new insight into the aetiology of endocranial lesions, distinguishing the lesions of vascular origin from those caused by tuberculosis or other conditions. The analysis is based on a rare case of a young female individual who displayed multiple endocranial lesions with ‘serpens endocrania symmetrica’ morphology. The lesions were associated with an uncommon branching pattern of the middle meningeal artery and marked side differences in teeth pathology. Postcranial skeleton showed signs of the left upper limb weakness. The macroscopic finding of the endocranial lesions along with the skeletal evidence of neurological damage, together with characteristic radiological and histological features, can lead to diagnosis of arteriovenous malformations. This study aims to improve understanding of the aetiology of endocranial bone lesions.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "International Journal of Osteoarchaeology",
title = "Intracranial Arteriovenous Malformations as a Possible Cause of Endocranial Bone Lesions and Associated Neurological Disorder",
volume = "25",
number = "1",
pages = "88-97",
doi = "https://doi.org/10.1002/oa.2266"
}

Janović, A., Milovanović, P., Sopta, J., Rakočević, Z., Filipović, V., Nenezić, D.,& Đurić, M.. (2015). Intracranial Arteriovenous Malformations as a Possible Cause of Endocranial Bone Lesions and Associated Neurological Disorder. in International Journal of Osteoarchaeology
Wiley-Blackwell, Hoboken., 25(1), 88-97.
https://doi.org/https://doi.org/10.1002/oa.2266

Janović A, Milovanović P, Sopta J, Rakočević Z, Filipović V, Nenezić D, Đurić M. Intracranial Arteriovenous Malformations as a Possible Cause of Endocranial Bone Lesions and Associated Neurological Disorder. in International Journal of Osteoarchaeology. 2015;25(1):88-97.
doi:https://doi.org/10.1002/oa.2266 .

Janović, Aleksa, Milovanović, Petar, Sopta, Jelena, Rakočević, Zoran, Filipović, Vojislav, Nenezić, Dragoslav, Đurić, Marija, "Intracranial Arteriovenous Malformations as a Possible Cause of Endocranial Bone Lesions and Associated Neurological Disorder" in International Journal of Osteoarchaeology, 25, no. 1 (2015):88-97,
https://doi.org/https://doi.org/10.1002/oa.2266 . .

TY  - JOUR
AU  - Golubović, Mileta
AU  - Petrović, Milan
AU  - Jelovac, Drago
AU  - Nenezić, Dragoslav U.
AU  - Antunović, Marija
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1718
AB  - Introduction. Ameloblastomas are odontogenic epithelial, locally invasive tumors of slow growth and mostly of benign behavior. Their frequency is low (they account for 1% of all head and neck tumors and about 11% of tumors of dental origin). Malignant variations of ameloblastoma are malignant ameloblastoma and ameloblastic carcinoma. They constitute less than 1% of all ameloblastomas. We presented a case of malignant ameloblastoma of the mandible with neck metastasis. Case report. A patient, aged 72, presented with the following symptoms: pain in the lower jaw, swelling in the left submandibular area and difficult mouth opening. The patient was admitted to the Department of Oral and Maxillofacial Surgery, Clinical Center of Montenegro, two months after he had noticed the symptoms. Panoramic radiography (OPG) showed that both jaws were partially toothless with terminal stage of periodontitis of the remaining teeth. Also, OPG showed sharply limited semicircular defect in the retromolar region and along the front edge of the mandible rami. Conventional histopathologic examination of the neck masses showed malignant ameloblastoma which contained central fields of squamous differentiation. Immunoreactivity of several markers was determined using immunohistochemical analyses. After these diagnostic methods a definite histopathology diagnosis was made: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Conclusion. It is not possible to distinguish conventional, ie intraosseous, ameloblastoma from malignant ameloblastoma according to histopathologic features. It is necessary to pay special attention, especially in elderly patients, and to carry out further clinical, radiological and pathohistological diagnostic procedures, such as immunohistochemical analysis. A timely and correct diagnosis and treatment of malignant ameloblastoma require a multidisciplinary approach.
AB  - Uvod. Ameloblastomi su odontogeni epitelni tumori, lokalno invazivni, sporog rasta, i u većini slučajeva pokazuju benigno ponašanje. Veoma su rijetki. Njihova učestalost je 1% u grupi tumora glave i vrata, kao i 11% kod tumora koji potiču od zubnih tkiva. Maligne varijante ameloblastoma su maligni ameloblastom i ameloblastički karcinom. Oni čine manje od 1% svih ameloblastoma. U radu je prikazan bolesnik sa malignim ameloblastomom donje vilice sa metastazom na vratu. Prikaz bolesnika. Prve subjektivne tegobe bolesnika, starog 72 godine, manifestovale su se kao bolovi u predelu donje vilice, otok u podviličnom predelu sa leve strane i otežano otvaranje usta. Bolesnik je primljen u Odeljenje oralne i maksilofacijalne hirurgije Kliničkog centra Crne Gore dva meseca nakon što je primetio prve tegobe. Ortopantomografski snimak pokazao je suptotalnu bezubost obeju vilica sa terminalnim stadijumom parodontopatije na preostalim zubima. U retromolarnoj regiji i duž prednje ivice ramusa donje vilice, uočen je jasno ograničen polukružni defekt. Biopsija promene na vratu pokazala je metastazu malignog ameloblastoma, sa prisutnim centralnim poljima skvamozne diferencijacije. Imunohistohemijskom analizom određivana je imunoreaktivnost više markera. Nakon ovih dijagnostičkih metoda postavljena je definitivna patohistološka dijagnoza: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Zaključak. Na osnovu histopatološkog nalaza nije moguće razlikovati konvencionalni, tj. intraosealni, ameloblastom od malignog ameloblastoma. Zbog toga je potrebno obratiti posebnu pažnju, naro čito kod bolesnika starijeg životnog doba, i sprovesti sve dodatne kliničke, radiološke i histopatološke, ali i imunohistohemijske dijagnostičke procedure. Za postavljanje blagovremene i tačne dijagnoze, kao i sprovođenje adekvatnog terapijskog tretmana malignog ameloblastoma, neophodan je multidisciplinarni pristup.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma
T1  - Metastaza malignog ameloblastoma na vratu - radiološka i patohistološka dilema
VL  - 69
IS  - 5
SP  - 444
EP  - 448
DO  - 10.2298/VSP1205444G
ER  - 

@article{
author = "Golubović, Mileta and Petrović, Milan and Jelovac, Drago and Nenezić, Dragoslav U. and Antunović, Marija",
year = "2012",
abstract = "Introduction. Ameloblastomas are odontogenic epithelial, locally invasive tumors of slow growth and mostly of benign behavior. Their frequency is low (they account for 1% of all head and neck tumors and about 11% of tumors of dental origin). Malignant variations of ameloblastoma are malignant ameloblastoma and ameloblastic carcinoma. They constitute less than 1% of all ameloblastomas. We presented a case of malignant ameloblastoma of the mandible with neck metastasis. Case report. A patient, aged 72, presented with the following symptoms: pain in the lower jaw, swelling in the left submandibular area and difficult mouth opening. The patient was admitted to the Department of Oral and Maxillofacial Surgery, Clinical Center of Montenegro, two months after he had noticed the symptoms. Panoramic radiography (OPG) showed that both jaws were partially toothless with terminal stage of periodontitis of the remaining teeth. Also, OPG showed sharply limited semicircular defect in the retromolar region and along the front edge of the mandible rami. Conventional histopathologic examination of the neck masses showed malignant ameloblastoma which contained central fields of squamous differentiation. Immunoreactivity of several markers was determined using immunohistochemical analyses. After these diagnostic methods a definite histopathology diagnosis was made: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Conclusion. It is not possible to distinguish conventional, ie intraosseous, ameloblastoma from malignant ameloblastoma according to histopathologic features. It is necessary to pay special attention, especially in elderly patients, and to carry out further clinical, radiological and pathohistological diagnostic procedures, such as immunohistochemical analysis. A timely and correct diagnosis and treatment of malignant ameloblastoma require a multidisciplinary approach., Uvod. Ameloblastomi su odontogeni epitelni tumori, lokalno invazivni, sporog rasta, i u većini slučajeva pokazuju benigno ponašanje. Veoma su rijetki. Njihova učestalost je 1% u grupi tumora glave i vrata, kao i 11% kod tumora koji potiču od zubnih tkiva. Maligne varijante ameloblastoma su maligni ameloblastom i ameloblastički karcinom. Oni čine manje od 1% svih ameloblastoma. U radu je prikazan bolesnik sa malignim ameloblastomom donje vilice sa metastazom na vratu. Prikaz bolesnika. Prve subjektivne tegobe bolesnika, starog 72 godine, manifestovale su se kao bolovi u predelu donje vilice, otok u podviličnom predelu sa leve strane i otežano otvaranje usta. Bolesnik je primljen u Odeljenje oralne i maksilofacijalne hirurgije Kliničkog centra Crne Gore dva meseca nakon što je primetio prve tegobe. Ortopantomografski snimak pokazao je suptotalnu bezubost obeju vilica sa terminalnim stadijumom parodontopatije na preostalim zubima. U retromolarnoj regiji i duž prednje ivice ramusa donje vilice, uočen je jasno ograničen polukružni defekt. Biopsija promene na vratu pokazala je metastazu malignog ameloblastoma, sa prisutnim centralnim poljima skvamozne diferencijacije. Imunohistohemijskom analizom određivana je imunoreaktivnost više markera. Nakon ovih dijagnostičkih metoda postavljena je definitivna patohistološka dijagnoza: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Zaključak. Na osnovu histopatološkog nalaza nije moguće razlikovati konvencionalni, tj. intraosealni, ameloblastom od malignog ameloblastoma. Zbog toga je potrebno obratiti posebnu pažnju, naro čito kod bolesnika starijeg životnog doba, i sprovesti sve dodatne kliničke, radiološke i histopatološke, ali i imunohistohemijske dijagnostičke procedure. Za postavljanje blagovremene i tačne dijagnoze, kao i sprovođenje adekvatnog terapijskog tretmana malignog ameloblastoma, neophodan je multidisciplinarni pristup.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma, Metastaza malignog ameloblastoma na vratu - radiološka i patohistološka dilema",
volume = "69",
number = "5",
pages = "444-448",
doi = "10.2298/VSP1205444G"
}

Golubović, M., Petrović, M., Jelovac, D., Nenezić, D. U.,& Antunović, M.. (2012). Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 69(5), 444-448.
https://doi.org/10.2298/VSP1205444G

Golubović M, Petrović M, Jelovac D, Nenezić DU, Antunović M. Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma. in Vojnosanitetski pregled. 2012;69(5):444-448.
doi:10.2298/VSP1205444G .

Golubović, Mileta, Petrović, Milan, Jelovac, Drago, Nenezić, Dragoslav U., Antunović, Marija, "Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma" in Vojnosanitetski pregled, 69, no. 5 (2012):444-448,
https://doi.org/10.2298/VSP1205444G . .