Petrović, Nada

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  • Petrović, Nada (1)
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Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study

Lazarević, Miloš; Milošević, Maja; Petrović, Nada; Petrović, Slobodan; Damante, Giuseppe; Milašin, Jelena; Milovanović, Branislav

(Udruženje stomatologa Balkana, 2019)

TY  - JOUR
AU  - Lazarević, Miloš
AU  - Milošević, Maja
AU  - Petrović, Nada
AU  - Petrović, Slobodan
AU  - Damante, Giuseppe
AU  - Milašin, Jelena
AU  - Milovanović, Branislav
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2403
AB  - Background/Aim: Current approaches in therapy of head and neck cancers are surgery, radiotherapy and chemotherapy. However, recurrence, development of multidrug resistance, side effects, and high costs of therapy are significant problems which point to the need for more efficient and less toxic drugs and interventions. Material and Methods: Eight essential oils obtained from Thymus serpyllum, Mentha piperita, Juniperus communis, Rosmarinus officinalis, Melissa officinalis, Achillea millefolium, Zingiber officinale, and Helichrysum arenarium were tested for their anti-proliferative on oral squamous cell carcinoma (OSCC) culture and SCC-25 cell line. Cytotoxicity assays (MTT and Neutral red) were used to detect the effect of the mentioned essential oils. Results: T. serpyllum, M. piperita, J. communis, and R. officinalis essential oils exhibited the best anti-proliferative effect, on both types of cells. M. piperita had the greatest effect on SCC-25 cell line (4,5% of viable cells) and OSCC cells (7,2% of viable cells). Overall, cytotoxicity was higher in OSCC than in SCC-25 cell line. Conclusions: This study showed a clear anti-proliferative effect of four essential oils, in vitro making them novel potential antineoplastic agents.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Dental Medicine
T1  - Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study
VL  - 23
IS  - 2
SP  - 73
EP  - 79
DO  - 10.2478/bjdm-2019-0014
ER  - 
@article{
author = "Lazarević, Miloš and Milošević, Maja and Petrović, Nada and Petrović, Slobodan and Damante, Giuseppe and Milašin, Jelena and Milovanović, Branislav",
year = "2019",
abstract = "Background/Aim: Current approaches in therapy of head and neck cancers are surgery, radiotherapy and chemotherapy. However, recurrence, development of multidrug resistance, side effects, and high costs of therapy are significant problems which point to the need for more efficient and less toxic drugs and interventions. Material and Methods: Eight essential oils obtained from Thymus serpyllum, Mentha piperita, Juniperus communis, Rosmarinus officinalis, Melissa officinalis, Achillea millefolium, Zingiber officinale, and Helichrysum arenarium were tested for their anti-proliferative on oral squamous cell carcinoma (OSCC) culture and SCC-25 cell line. Cytotoxicity assays (MTT and Neutral red) were used to detect the effect of the mentioned essential oils. Results: T. serpyllum, M. piperita, J. communis, and R. officinalis essential oils exhibited the best anti-proliferative effect, on both types of cells. M. piperita had the greatest effect on SCC-25 cell line (4,5% of viable cells) and OSCC cells (7,2% of viable cells). Overall, cytotoxicity was higher in OSCC than in SCC-25 cell line. Conclusions: This study showed a clear anti-proliferative effect of four essential oils, in vitro making them novel potential antineoplastic agents.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Dental Medicine",
title = "Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study",
volume = "23",
number = "2",
pages = "73-79",
doi = "10.2478/bjdm-2019-0014"
}
Lazarević, M., Milošević, M., Petrović, N., Petrović, S., Damante, G., Milašin, J.,& Milovanović, B.. (2019). Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study. in Balkan Journal of Dental Medicine
Udruženje stomatologa Balkana., 23(2), 73-79.
https://doi.org/10.2478/bjdm-2019-0014
Lazarević M, Milošević M, Petrović N, Petrović S, Damante G, Milašin J, Milovanović B. Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study. in Balkan Journal of Dental Medicine. 2019;23(2):73-79.
doi:10.2478/bjdm-2019-0014 .
Lazarević, Miloš, Milošević, Maja, Petrović, Nada, Petrović, Slobodan, Damante, Giuseppe, Milašin, Jelena, Milovanović, Branislav, "Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study" in Balkan Journal of Dental Medicine, 23, no. 2 (2019):73-79,
https://doi.org/10.2478/bjdm-2019-0014 . .
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