TY  - JOUR
AU  - Stanković, Ivana
AU  - Kesić, Ljiljana
AU  - Milašin, Jelena
AU  - Obradović, Radmila
AU  - Petrović, Milica S.
AU  - Bojović, Marija
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2338
AB  - Periodontal disease and Dental caries associated with dental plaque are the most common bacterial diseases, but also, significant oral health problem is Candidiasis. Candida albicans, is an opportunistic pathogen that can, under certain conditions proliferate and cause infections. The need for prevention and alternative forms of treatment and products for oral diseases comes from the rise in disease incidence, increased resistance by pathogenic bacteria to currently used chemotherapeutics. The products derived from medicinal plants have proven to be a source of biologically active substances, and thanks to their active principles, products based on medical herbs are more prevalent in modern phytotherapy. Essential oils are complex natural mixtures of volatile secondary metabolites - aliphatic and aromatic, terpinen and phenyl- propane compounds isolated from plants. The main constituents of essential oils are terpenes and sesquiterpenes including carbohydrates, alcohols, ethers, aldehydes and ketones, which are responsible for the fragrant and biological properties of plants. Different oils produce various pharmacological effects such as anti-inflammatory, antioxidant and anticancerogenic properties, but also oils are biocides. There are numerous in vitro studies that dealt with the research activities of natural herbal substances against oral bacteria that are known to be etiological factors in the development of oral and dental diseases. The phenolic major compounds of essential oils have been suggested to have a potential antifungal activity. There is ample of evidence that plant extracts and essential oils have the potential to be developed into agents that can be used as preventative or treatment therapies of oral diseases.
AB  - Parodontopatija i dentalni karijes, čiji je nastanak povezan sa dentalnim plakom, predstavljaju najčešća bakterijska oboljenja. Takođe, značajni oralni zdravstveni problem predstavlja i kandidijaza. Candida albicans je oportunistički patogen koji pod pojedinim okolnostima može da proliferiše i uzrokuje infekciju. Potreba za prevencijom i alternativnim oblicima lečenja i produktima za oralna oboljenja proizilazi zbog povećanja učestalosti oboljenja i povećane rezistencije patogenih bakterija na primenu hemoterapeutika koji se trenutno upotrebljavaju. Dokazano je da su produkti dobijeni od lekovitog bilja izvor biološko aktivnih supstanci, a zahvaljujući svojim aktivnim principima, produkti na bazi lekovitog bilja zastupljeniji su u modernoj fitoterapiji. Eterična ulja su kompleksne prirodne mešavine isparljivih sekundarnih metabolita - alifatičnih i aromatičnih, terpenskih i fenil-propanskih jedinjenja izolovanih iz biljaka. Glavni sastojci etarskih ulja su terpeni i seskviterpeni, uključujući i ugljene hidrate, alkohol, etar, aldehide i ketone, koji su odgovorni za mirisna i biološka svojstva biljaka. Različita ulja imaju brojne farmakološke efekte, kao što su antiinflamatorno, antioksidativno i antikancerogeno dejstvo, ali su takođe i biocidi. Postoje brojne in vitro studije koje su se bavile istraživanjem aktivnosti prirodnih biljnih supstanci usmerenih na oralne bakterije za koje je poznato da su etiološki faktori u nastanku oralnih i dentalnih oboljenja. Navedeno je da glavne fenolne komponente eteričnih ulja imaju potencijalnu antigljivičnu aktivnost. Postoje brojni dokazi da biljni ekstrakti i eterična ulja imaju potencijal da se razviju u agense koji se mogu koristiti u preventivi ili u lečenju oralnih oboljenja.
PB  - Univerzitet u Nišu - Medicinski fakultet, Niš
T2  - Acta medica Medianae
T1  - Antimicrobial activity of essential oils against oral pathogens: Informative article
T1  - Antimikrobno dejstvo eteričnih ulja na oralne patogene
VL  - 57
IS  - 3
SP  - 115
EP  - 123
DO  - 10.5633/amm.2018.0316
ER  - 

@article{
author = "Stanković, Ivana and Kesić, Ljiljana and Milašin, Jelena and Obradović, Radmila and Petrović, Milica S. and Bojović, Marija",
year = "2018",
abstract = "Periodontal disease and Dental caries associated with dental plaque are the most common bacterial diseases, but also, significant oral health problem is Candidiasis. Candida albicans, is an opportunistic pathogen that can, under certain conditions proliferate and cause infections. The need for prevention and alternative forms of treatment and products for oral diseases comes from the rise in disease incidence, increased resistance by pathogenic bacteria to currently used chemotherapeutics. The products derived from medicinal plants have proven to be a source of biologically active substances, and thanks to their active principles, products based on medical herbs are more prevalent in modern phytotherapy. Essential oils are complex natural mixtures of volatile secondary metabolites - aliphatic and aromatic, terpinen and phenyl- propane compounds isolated from plants. The main constituents of essential oils are terpenes and sesquiterpenes including carbohydrates, alcohols, ethers, aldehydes and ketones, which are responsible for the fragrant and biological properties of plants. Different oils produce various pharmacological effects such as anti-inflammatory, antioxidant and anticancerogenic properties, but also oils are biocides. There are numerous in vitro studies that dealt with the research activities of natural herbal substances against oral bacteria that are known to be etiological factors in the development of oral and dental diseases. The phenolic major compounds of essential oils have been suggested to have a potential antifungal activity. There is ample of evidence that plant extracts and essential oils have the potential to be developed into agents that can be used as preventative or treatment therapies of oral diseases., Parodontopatija i dentalni karijes, čiji je nastanak povezan sa dentalnim plakom, predstavljaju najčešća bakterijska oboljenja. Takođe, značajni oralni zdravstveni problem predstavlja i kandidijaza. Candida albicans je oportunistički patogen koji pod pojedinim okolnostima može da proliferiše i uzrokuje infekciju. Potreba za prevencijom i alternativnim oblicima lečenja i produktima za oralna oboljenja proizilazi zbog povećanja učestalosti oboljenja i povećane rezistencije patogenih bakterija na primenu hemoterapeutika koji se trenutno upotrebljavaju. Dokazano je da su produkti dobijeni od lekovitog bilja izvor biološko aktivnih supstanci, a zahvaljujući svojim aktivnim principima, produkti na bazi lekovitog bilja zastupljeniji su u modernoj fitoterapiji. Eterična ulja su kompleksne prirodne mešavine isparljivih sekundarnih metabolita - alifatičnih i aromatičnih, terpenskih i fenil-propanskih jedinjenja izolovanih iz biljaka. Glavni sastojci etarskih ulja su terpeni i seskviterpeni, uključujući i ugljene hidrate, alkohol, etar, aldehide i ketone, koji su odgovorni za mirisna i biološka svojstva biljaka. Različita ulja imaju brojne farmakološke efekte, kao što su antiinflamatorno, antioksidativno i antikancerogeno dejstvo, ali su takođe i biocidi. Postoje brojne in vitro studije koje su se bavile istraživanjem aktivnosti prirodnih biljnih supstanci usmerenih na oralne bakterije za koje je poznato da su etiološki faktori u nastanku oralnih i dentalnih oboljenja. Navedeno je da glavne fenolne komponente eteričnih ulja imaju potencijalnu antigljivičnu aktivnost. Postoje brojni dokazi da biljni ekstrakti i eterična ulja imaju potencijal da se razviju u agense koji se mogu koristiti u preventivi ili u lečenju oralnih oboljenja.",
publisher = "Univerzitet u Nišu - Medicinski fakultet, Niš",
journal = "Acta medica Medianae",
title = "Antimicrobial activity of essential oils against oral pathogens: Informative article, Antimikrobno dejstvo eteričnih ulja na oralne patogene",
volume = "57",
number = "3",
pages = "115-123",
doi = "10.5633/amm.2018.0316"
}

Stanković, I., Kesić, L., Milašin, J., Obradović, R., Petrović, M. S.,& Bojović, M.. (2018). Antimicrobial activity of essential oils against oral pathogens: Informative article. in Acta medica Medianae
Univerzitet u Nišu - Medicinski fakultet, Niš., 57(3), 115-123.
https://doi.org/10.5633/amm.2018.0316

Stanković I, Kesić L, Milašin J, Obradović R, Petrović MS, Bojović M. Antimicrobial activity of essential oils against oral pathogens: Informative article. in Acta medica Medianae. 2018;57(3):115-123.
doi:10.5633/amm.2018.0316 .

Stanković, Ivana, Kesić, Ljiljana, Milašin, Jelena, Obradović, Radmila, Petrović, Milica S., Bojović, Marija, "Antimicrobial activity of essential oils against oral pathogens: Informative article" in Acta medica Medianae, 57, no. 3 (2018):115-123,
https://doi.org/10.5633/amm.2018.0316 . .

TY  - JOUR
AU  - Petrović, M. S.
AU  - Kannosh, Ibrahim
AU  - Milašin, Jelena
AU  - Mihailović, D. S.
AU  - Obradović, Radmila
AU  - Bubanj, S. R.
AU  - Kesić, Ljiljana
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2286
AB  - ObjectiveA clinical prospective study was designed to evaluate microbiological, cytomorphometric and clinical efficacy of low-level laser therapy (LLLT) as an adjunct to periodontal therapy in the treatment of chronic periodontitis. MethodsSixty subjects were included and randomly assigned into 2 groups: SRP (scaling root planning) group (n=30) and LLLT+SRP group (n=30). Clinical parameters were measured before intervention, after the fifth treatment, and after a month. All subjects received oral hygiene instructions and full-mouth conservative periodontal treatment (removal of dental plaque followed by SRP). Afterwards, in group II, Kavo LLLT (980nm, 0.2W, 6J/cm(2)) was applied. Subgingival samples were collected at baseline and after the fifth treatment to quantify Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythensis and Treponema denticola by polymerase chain reaction (PCR). Gingival swabs were taken, and direct smears were prepared on slides for cytomorphometric analysis. ResultsEvaluation using clinical parameters showed better results in LLLT group. A statistically significant decrease in the prevalence of bacteria after treatment in LLLT group was observed for the following: T.forsythensis and T.denticola (P lt .001), P.gingivalis (P lt .01), A.actinomycetemcomitans and P.intermedia (P lt .05). The values of nuclear area, perimeter and Ferret's diameter were significantly lower in both studied groups after treatment, but statistical significance was higher in LLLT group (P lt .001) than in the SRP therapy group (P lt .05). ConclusionLow-level laser therapy as an adjunct to periodontal therapy demonstrates short-term additional bacteriological, cytological and clinical benefits.
PB  - Wiley, Hoboken
T2  - International Journal of Dental Hygiene
T1  - Clinical, microbiological and cytomorphometric evaluation of low-level laser therapy as an adjunct to periodontal therapy in patients with chronic periodontitis
VL  - 16
IS  - 2
SP  - E120
EP  - E127
DO  - 10.1111/idh.12328
ER  - 

@article{
author = "Petrović, M. S. and Kannosh, Ibrahim and Milašin, Jelena and Mihailović, D. S. and Obradović, Radmila and Bubanj, S. R. and Kesić, Ljiljana",
year = "2018",
abstract = "ObjectiveA clinical prospective study was designed to evaluate microbiological, cytomorphometric and clinical efficacy of low-level laser therapy (LLLT) as an adjunct to periodontal therapy in the treatment of chronic periodontitis. MethodsSixty subjects were included and randomly assigned into 2 groups: SRP (scaling root planning) group (n=30) and LLLT+SRP group (n=30). Clinical parameters were measured before intervention, after the fifth treatment, and after a month. All subjects received oral hygiene instructions and full-mouth conservative periodontal treatment (removal of dental plaque followed by SRP). Afterwards, in group II, Kavo LLLT (980nm, 0.2W, 6J/cm(2)) was applied. Subgingival samples were collected at baseline and after the fifth treatment to quantify Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythensis and Treponema denticola by polymerase chain reaction (PCR). Gingival swabs were taken, and direct smears were prepared on slides for cytomorphometric analysis. ResultsEvaluation using clinical parameters showed better results in LLLT group. A statistically significant decrease in the prevalence of bacteria after treatment in LLLT group was observed for the following: T.forsythensis and T.denticola (P lt .001), P.gingivalis (P lt .01), A.actinomycetemcomitans and P.intermedia (P lt .05). The values of nuclear area, perimeter and Ferret's diameter were significantly lower in both studied groups after treatment, but statistical significance was higher in LLLT group (P lt .001) than in the SRP therapy group (P lt .05). ConclusionLow-level laser therapy as an adjunct to periodontal therapy demonstrates short-term additional bacteriological, cytological and clinical benefits.",
publisher = "Wiley, Hoboken",
journal = "International Journal of Dental Hygiene",
title = "Clinical, microbiological and cytomorphometric evaluation of low-level laser therapy as an adjunct to periodontal therapy in patients with chronic periodontitis",
volume = "16",
number = "2",
pages = "E120-E127",
doi = "10.1111/idh.12328"
}

Petrović, M. S., Kannosh, I., Milašin, J., Mihailović, D. S., Obradović, R., Bubanj, S. R.,& Kesić, L.. (2018). Clinical, microbiological and cytomorphometric evaluation of low-level laser therapy as an adjunct to periodontal therapy in patients with chronic periodontitis. in International Journal of Dental Hygiene
Wiley, Hoboken., 16(2), E120-E127.
https://doi.org/10.1111/idh.12328

Petrović MS, Kannosh I, Milašin J, Mihailović DS, Obradović R, Bubanj SR, Kesić L. Clinical, microbiological and cytomorphometric evaluation of low-level laser therapy as an adjunct to periodontal therapy in patients with chronic periodontitis. in International Journal of Dental Hygiene. 2018;16(2):E120-E127.
doi:10.1111/idh.12328 .

Petrović, M. S., Kannosh, Ibrahim, Milašin, Jelena, Mihailović, D. S., Obradović, Radmila, Bubanj, S. R., Kesić, Ljiljana, "Clinical, microbiological and cytomorphometric evaluation of low-level laser therapy as an adjunct to periodontal therapy in patients with chronic periodontitis" in International Journal of Dental Hygiene, 16, no. 2 (2018):E120-E127,
https://doi.org/10.1111/idh.12328 . .

TY  - CHAP
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Jovanović, Tanja
AU  - Kesić, Ljiljana
AU  - Milasin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2597
AB  - Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.
PB  - Rijeka : InTech
T2  - Herpesviridae
T1  - Herpesviruses in Periapical Pathoses: An Updated Systematic Review
SP  - 31
EP  - 74
DO  - 10.5772/64004
ER  - 

@inbook{
editor = "Ongrádi, Joseph",
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Miletić, Maja and Jovanović, Tanja and Kesić, Ljiljana and Milasin, Jelena",
year = "2016",
abstract = "Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.",
publisher = "Rijeka : InTech",
journal = "Herpesviridae",
booktitle = "Herpesviruses in Periapical Pathoses: An Updated Systematic Review",
pages = "31-74",
doi = "10.5772/64004"
}

Ongrádi, J., Jakovljević, A., Andrić, M., Knežević, A., Beljić-Ivanović, K., Miletić, M., Jovanović, T., Kesić, L.,& Milasin, J.. (2016). Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae
Rijeka : InTech., 31-74.
https://doi.org/10.5772/64004

Ongrádi J, Jakovljević A, Andrić M, Knežević A, Beljić-Ivanović K, Miletić M, Jovanović T, Kesić L, Milasin J. Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae. 2016;:31-74.
doi:10.5772/64004 .

Ongrádi, Joseph, Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Miletić, Maja, Jovanović, Tanja, Kesić, Ljiljana, Milasin, Jelena, "Herpesviruses in Periapical Pathoses: An Updated Systematic Review" in Herpesviridae (2016):31-74,
https://doi.org/10.5772/64004 . .

TY  - JOUR
AU  - Popović, Jelena
AU  - Gašić, Jovanka
AU  - Živković, Slavoljub
AU  - Kesić, Ljiljana
AU  - Mitić, Aleksandar
AU  - Nikolić, Marija
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2007
AB  - Objective: The aim of this study was to investigate the presence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the tissue of chronic periapical lesions, and to compare the results in relation to the symptoms of patients and the size of the lesion. Methods: Periapical lesions analyzed in the study were collected from the roots of the teeth indicated for extraction. Samples were divided according to the symptoms into groups of symptomatic and asymptomatic, and according the size into groups of small and large lesions. Polymerase chain reaction was used to detect HCMV and EBV. The amplification was performed in a DNA Thermal Cycler (Hybaid). Results: Symptomatic lesions were 7.68 times more likely to be infected with HCMV than asymptomatic lesions (p  lt  0.001). Large symptomatic lesions were 73.50 times more likely to harbor HCMV than small symptomatic lesions (p  lt  0.001). Large symptomatic lesions were 7.64 times more likely to be infected with EBV than small symptomatic lesions (p = 0.05). Large symptomatic lesions were 5.38 times more likely to harbor dual HCMV/EBV infection than small symptomatic lesions (p = 0.115). Conclusion: Detection of HCMV and EBV in the samples of periapical lesions suggests an important role of herpesviruses in periapical tissue destruction.
PB  - Karger, Basel
T2  - Intervirology
T1  - Prevalence of Human Cytomegalovirus and Epstein-Barr Virus in Chronic Periapical Lesions
VL  - 58
IS  - 5
SP  - 271
EP  - 277
DO  - 10.1159/000441208
ER  - 

@article{
author = "Popović, Jelena and Gašić, Jovanka and Živković, Slavoljub and Kesić, Ljiljana and Mitić, Aleksandar and Nikolić, Marija and Milašin, Jelena",
year = "2015",
abstract = "Objective: The aim of this study was to investigate the presence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the tissue of chronic periapical lesions, and to compare the results in relation to the symptoms of patients and the size of the lesion. Methods: Periapical lesions analyzed in the study were collected from the roots of the teeth indicated for extraction. Samples were divided according to the symptoms into groups of symptomatic and asymptomatic, and according the size into groups of small and large lesions. Polymerase chain reaction was used to detect HCMV and EBV. The amplification was performed in a DNA Thermal Cycler (Hybaid). Results: Symptomatic lesions were 7.68 times more likely to be infected with HCMV than asymptomatic lesions (p  lt  0.001). Large symptomatic lesions were 73.50 times more likely to harbor HCMV than small symptomatic lesions (p  lt  0.001). Large symptomatic lesions were 7.64 times more likely to be infected with EBV than small symptomatic lesions (p = 0.05). Large symptomatic lesions were 5.38 times more likely to harbor dual HCMV/EBV infection than small symptomatic lesions (p = 0.115). Conclusion: Detection of HCMV and EBV in the samples of periapical lesions suggests an important role of herpesviruses in periapical tissue destruction.",
publisher = "Karger, Basel",
journal = "Intervirology",
title = "Prevalence of Human Cytomegalovirus and Epstein-Barr Virus in Chronic Periapical Lesions",
volume = "58",
number = "5",
pages = "271-277",
doi = "10.1159/000441208"
}

Popović, J., Gašić, J., Živković, S., Kesić, L., Mitić, A., Nikolić, M.,& Milašin, J.. (2015). Prevalence of Human Cytomegalovirus and Epstein-Barr Virus in Chronic Periapical Lesions. in Intervirology
Karger, Basel., 58(5), 271-277.
https://doi.org/10.1159/000441208

Popović J, Gašić J, Živković S, Kesić L, Mitić A, Nikolić M, Milašin J. Prevalence of Human Cytomegalovirus and Epstein-Barr Virus in Chronic Periapical Lesions. in Intervirology. 2015;58(5):271-277.
doi:10.1159/000441208 .

Popović, Jelena, Gašić, Jovanka, Živković, Slavoljub, Kesić, Ljiljana, Mitić, Aleksandar, Nikolić, Marija, Milašin, Jelena, "Prevalence of Human Cytomegalovirus and Epstein-Barr Virus in Chronic Periapical Lesions" in Intervirology, 58, no. 5 (2015):271-277,
https://doi.org/10.1159/000441208 . .

TY  - JOUR
AU  - Igić, M.
AU  - Kesić, Ljiljana
AU  - Leković, Vojislav
AU  - Apostolović, Mirjana
AU  - Mihailović, D.
AU  - Kostadinović, Ljiljana
AU  - Milašin, Jelena
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1765
AB  - The purpose of this study was to determine the level of gingival inflammation and the prevalence of periodontopathogenic microorganisms in adolescents with chronic gingivitis, as well as to compare the effectiveness of two approaches in gingivitis treatment-basic therapy alone and basic therapy + adjunctive low-level laser therapy (LLLT). After periodontal evaluation, the content of gingival pockets of 140 adolescents with gingivitis was analyzed by multiplex PCR for the presence of P. gingivalis, A. actinomycetemcomitans, T. forsythensis and P. intermedia. Subsequent to bacteria detection, the examinees were divided into two groups with homogenous clinical and microbiological characteristics. Group A was subjected to basic gingivitis therapy, and group B underwent basic therapy along with adjunctive LLLT. A statistically significant difference between the values of plaque-index (PI) and sulcus bleeding index (SBI) before and after therapy was confirmed in both groups (p  lt  0.001), though more pronounced in group B. Following therapy, the incidence of periodontopathogenic microorganisms decreased considerably. The best result was obtained in P. gingivalis eradication by combined therapy (p = 0.003). The presence of periodontopathogens in adolescents with gingivitis should be regarded as a sign for dentists to foster more effective oral health programs. LLLT appears to be beneficial as adjuvant to basic therapy.
PB  - Springer, New York
T2  - European Journal of Clinical Microbiology & Infectious Diseases
T1  - Chronic gingivitis: the prevalence of periodontopathogens and therapy efficiency
VL  - 31
IS  - 8
SP  - 1911
EP  - 1915
DO  - 10.1007/s10096-011-1520-7
ER  - 

@article{
author = "Igić, M. and Kesić, Ljiljana and Leković, Vojislav and Apostolović, Mirjana and Mihailović, D. and Kostadinović, Ljiljana and Milašin, Jelena",
year = "2012",
abstract = "The purpose of this study was to determine the level of gingival inflammation and the prevalence of periodontopathogenic microorganisms in adolescents with chronic gingivitis, as well as to compare the effectiveness of two approaches in gingivitis treatment-basic therapy alone and basic therapy + adjunctive low-level laser therapy (LLLT). After periodontal evaluation, the content of gingival pockets of 140 adolescents with gingivitis was analyzed by multiplex PCR for the presence of P. gingivalis, A. actinomycetemcomitans, T. forsythensis and P. intermedia. Subsequent to bacteria detection, the examinees were divided into two groups with homogenous clinical and microbiological characteristics. Group A was subjected to basic gingivitis therapy, and group B underwent basic therapy along with adjunctive LLLT. A statistically significant difference between the values of plaque-index (PI) and sulcus bleeding index (SBI) before and after therapy was confirmed in both groups (p  lt  0.001), though more pronounced in group B. Following therapy, the incidence of periodontopathogenic microorganisms decreased considerably. The best result was obtained in P. gingivalis eradication by combined therapy (p = 0.003). The presence of periodontopathogens in adolescents with gingivitis should be regarded as a sign for dentists to foster more effective oral health programs. LLLT appears to be beneficial as adjuvant to basic therapy.",
publisher = "Springer, New York",
journal = "European Journal of Clinical Microbiology & Infectious Diseases",
title = "Chronic gingivitis: the prevalence of periodontopathogens and therapy efficiency",
volume = "31",
number = "8",
pages = "1911-1915",
doi = "10.1007/s10096-011-1520-7"
}

Igić, M., Kesić, L., Leković, V., Apostolović, M., Mihailović, D., Kostadinović, L.,& Milašin, J.. (2012). Chronic gingivitis: the prevalence of periodontopathogens and therapy efficiency. in European Journal of Clinical Microbiology & Infectious Diseases
Springer, New York., 31(8), 1911-1915.
https://doi.org/10.1007/s10096-011-1520-7

Igić M, Kesić L, Leković V, Apostolović M, Mihailović D, Kostadinović L, Milašin J. Chronic gingivitis: the prevalence of periodontopathogens and therapy efficiency. in European Journal of Clinical Microbiology & Infectious Diseases. 2012;31(8):1911-1915.
doi:10.1007/s10096-011-1520-7 .

Igić, M., Kesić, Ljiljana, Leković, Vojislav, Apostolović, Mirjana, Mihailović, D., Kostadinović, Ljiljana, Milašin, Jelena, "Chronic gingivitis: the prevalence of periodontopathogens and therapy efficiency" in European Journal of Clinical Microbiology & Infectious Diseases, 31, no. 8 (2012):1911-1915,
https://doi.org/10.1007/s10096-011-1520-7 . .

TY  - JOUR
AU  - Igić, Marija
AU  - Mihailović, Dragan
AU  - Kesić, Ljiljana
AU  - Milašin, Jelena
AU  - Apostolović, Mirjana
AU  - Kostadinović, Ljiljana
AU  - Tricković-Janjić, Olivera
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1691
AB  - Gingival epithelial cells are the first physical barrier against periodontal pathogenic microorganisms. Bacterial products may penetrate the epithelium and directly disturb its integrity. We investigated the clinical and cytomorphological status of the gingiva in children with gingivitis before and after low-level laser therapy. The study enrolled 130 children divided into three groups: group 1 comprised 50 children with chronic catarrhal gingivitis who received basic treatment, group 2 comprised 50 children with chronic catarrhal gingivitis who received low-level laser treatment in addition to basic treatment, and group 3 comprised 30 children with healthy gingiva as controls. Oral hygiene and the status of the gingiva were assessed using the appropriate indexes before and after treatment. Inflammation of the gingiva was monitored by cytomorphometric evaluation. Cytomorphometric analysis revealed a statistically significant difference (p  lt  0.001) in the size of the nuclei of the stratified squamous epithelial cells of the gingiva before and after treatment in chronic catarrhal gingivitis. Evaluation using clinical parameters showed that treatment of gingivitis with basic treatment was successful. Cytomorphometric analysis showed that after basic treatment the nuclei of the stratified squamous epithelial cells of the gingiva were reduced in size, although not to the size found in healthy gingiva. However, after adjuvant low-level laser therapy, the size of the nuclei of the stratified squamous epithelial cells in the gingiva matched the size of the nuclei in the cells in healthy gingiva.
PB  - Springer London Ltd, London
T2  - Lasers in Medical Science
T1  - Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children
VL  - 27
IS  - 4
SP  - 843
EP  - 848
DO  - 10.1007/s10103-011-0993-z
ER  - 

@article{
author = "Igić, Marija and Mihailović, Dragan and Kesić, Ljiljana and Milašin, Jelena and Apostolović, Mirjana and Kostadinović, Ljiljana and Tricković-Janjić, Olivera",
year = "2012",
abstract = "Gingival epithelial cells are the first physical barrier against periodontal pathogenic microorganisms. Bacterial products may penetrate the epithelium and directly disturb its integrity. We investigated the clinical and cytomorphological status of the gingiva in children with gingivitis before and after low-level laser therapy. The study enrolled 130 children divided into three groups: group 1 comprised 50 children with chronic catarrhal gingivitis who received basic treatment, group 2 comprised 50 children with chronic catarrhal gingivitis who received low-level laser treatment in addition to basic treatment, and group 3 comprised 30 children with healthy gingiva as controls. Oral hygiene and the status of the gingiva were assessed using the appropriate indexes before and after treatment. Inflammation of the gingiva was monitored by cytomorphometric evaluation. Cytomorphometric analysis revealed a statistically significant difference (p  lt  0.001) in the size of the nuclei of the stratified squamous epithelial cells of the gingiva before and after treatment in chronic catarrhal gingivitis. Evaluation using clinical parameters showed that treatment of gingivitis with basic treatment was successful. Cytomorphometric analysis showed that after basic treatment the nuclei of the stratified squamous epithelial cells of the gingiva were reduced in size, although not to the size found in healthy gingiva. However, after adjuvant low-level laser therapy, the size of the nuclei of the stratified squamous epithelial cells in the gingiva matched the size of the nuclei in the cells in healthy gingiva.",
publisher = "Springer London Ltd, London",
journal = "Lasers in Medical Science",
title = "Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children",
volume = "27",
number = "4",
pages = "843-848",
doi = "10.1007/s10103-011-0993-z"
}

Igić, M., Mihailović, D., Kesić, L., Milašin, J., Apostolović, M., Kostadinović, L.,& Tricković-Janjić, O.. (2012). Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children. in Lasers in Medical Science
Springer London Ltd, London., 27(4), 843-848.
https://doi.org/10.1007/s10103-011-0993-z

Igić M, Mihailović D, Kesić L, Milašin J, Apostolović M, Kostadinović L, Tricković-Janjić O. Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children. in Lasers in Medical Science. 2012;27(4):843-848.
doi:10.1007/s10103-011-0993-z .

Igić, Marija, Mihailović, Dragan, Kesić, Ljiljana, Milašin, Jelena, Apostolović, Mirjana, Kostadinović, Ljiljana, Tricković-Janjić, Olivera, "Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children" in Lasers in Medical Science, 27, no. 4 (2012):843-848,
https://doi.org/10.1007/s10103-011-0993-z . .

TY  - JOUR
AU  - Pejčić, Nataša
AU  - Kesić, Ljiljana
AU  - Milašin, Jelena
AU  - Pešić, Zoran
AU  - Mirković, D.
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1676
AB  - Objective: Recent epidemiological studies have shown that individuals with periodontitis have significantly increased risk of developing coronary heart disease. Although the mechanism responsible for the relationship between periodontal disease and cardiovascular events is not fully understood, it is hypothesized that the removal of infection and inflammatory burden of periodontitis by therapy would be accompanied by a decrease in levels of the inflammatory marker C-reactive protein and a decreased risk of coronary heart disease. The aim of the present study was to determine whether the presence of chronic periodontitis and periodontal pathogens and subsequent periodontal treatment could influence the serum levels of C-reactive protein in a Serbian cohort. Material and Methods: Fifty adults with moderate to severe periodontitis who underwent complete mouth disinfection were evaluated to determine if periodontal therapy would result in decreased periodontal infammation and lower serum levels of an inflammatory marker. Subjects underwent measuring of periodontal disease severity and serum C-reactive protein, and periodontal pathogens (Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans) at the time of the baseline visit and again 6 and 12 months after treatment. Serum levels CRP were also obtained from 25 subjects without periodontitis in a control group. Results: The levels of CRP in the serum seemed not to be lower than those reported in other population in Western European countries. There were significant changes in clinical periodontal values, CRP levels and presence of periodontal pathogens when baseline values were compared to those taken after periodontal treatment completion. Conclusion: The obtained results confirm the hypothesis that periodontal therapy may contribute to elimination of periodontal inflammation and periodontal pathogens, and reduce serum level of CRP. Periodontitis may contribute to the systemic inflammatory burden of affected individuals since it was shown that periodontal therapy may decrease presence of periodontal pathogens and inflammatory markers.
PB  - University of Zagreb. School of Dental Medicine
T2  - Acta Stomatologica Croatica
T1  - The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients
T1  - Utjecaj parodontološke terapije na C-reaktivni protein i parodontne patogene kod pacijenata s parodontopatijom
VL  - 45
IS  - 1
SP  - 14
EP  - 23
UR  - https://hdl.handle.net/21.15107/rcub_smile_1676
ER  - 

@article{
author = "Pejčić, Nataša and Kesić, Ljiljana and Milašin, Jelena and Pešić, Zoran and Mirković, D.",
year = "2011",
abstract = "Objective: Recent epidemiological studies have shown that individuals with periodontitis have significantly increased risk of developing coronary heart disease. Although the mechanism responsible for the relationship between periodontal disease and cardiovascular events is not fully understood, it is hypothesized that the removal of infection and inflammatory burden of periodontitis by therapy would be accompanied by a decrease in levels of the inflammatory marker C-reactive protein and a decreased risk of coronary heart disease. The aim of the present study was to determine whether the presence of chronic periodontitis and periodontal pathogens and subsequent periodontal treatment could influence the serum levels of C-reactive protein in a Serbian cohort. Material and Methods: Fifty adults with moderate to severe periodontitis who underwent complete mouth disinfection were evaluated to determine if periodontal therapy would result in decreased periodontal infammation and lower serum levels of an inflammatory marker. Subjects underwent measuring of periodontal disease severity and serum C-reactive protein, and periodontal pathogens (Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans) at the time of the baseline visit and again 6 and 12 months after treatment. Serum levels CRP were also obtained from 25 subjects without periodontitis in a control group. Results: The levels of CRP in the serum seemed not to be lower than those reported in other population in Western European countries. There were significant changes in clinical periodontal values, CRP levels and presence of periodontal pathogens when baseline values were compared to those taken after periodontal treatment completion. Conclusion: The obtained results confirm the hypothesis that periodontal therapy may contribute to elimination of periodontal inflammation and periodontal pathogens, and reduce serum level of CRP. Periodontitis may contribute to the systemic inflammatory burden of affected individuals since it was shown that periodontal therapy may decrease presence of periodontal pathogens and inflammatory markers.",
publisher = "University of Zagreb. School of Dental Medicine",
journal = "Acta Stomatologica Croatica",
title = "The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients, Utjecaj parodontološke terapije na C-reaktivni protein i parodontne patogene kod pacijenata s parodontopatijom",
volume = "45",
number = "1",
pages = "14-23",
url = "https://hdl.handle.net/21.15107/rcub_smile_1676"
}

Pejčić, N., Kesić, L., Milašin, J., Pešić, Z.,& Mirković, D.. (2011). The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients. in Acta Stomatologica Croatica
University of Zagreb. School of Dental Medicine., 45(1), 14-23.
https://hdl.handle.net/21.15107/rcub_smile_1676

Pejčić N, Kesić L, Milašin J, Pešić Z, Mirković D. The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients. in Acta Stomatologica Croatica. 2011;45(1):14-23.
https://hdl.handle.net/21.15107/rcub_smile_1676 .

Pejčić, Nataša, Kesić, Ljiljana, Milašin, Jelena, Pešić, Zoran, Mirković, D., "The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients" in Acta Stomatologica Croatica, 45, no. 1 (2011):14-23,
https://hdl.handle.net/21.15107/rcub_smile_1676 .

TY  - JOUR
AU  - Pejčić, Nataša
AU  - Kesić, Ljiljana
AU  - Milašin, Jelena
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1609
AB  - Periodontitis has been identified as a potential risk factor for systemic pathologies such as cardiovascular disease (CVD). The aims of this investigation were to assess the relationship between periodontitis and systemic inflammatory factor, as well as to discover whether there is a relation to the severity of periodontitis and to the periodontopathogens. Periodontal examinations and serum C-reactive protein (CRP) level measurements were performed in 50 patients with periodontitis. Periodontal health indicators included the gingival bleeding on probing index and periodontal disease status. The patients with moderate periodontitis had low attachment loss and pocket depth  lt  4 mm. The patients with severe periodontitis had high attachment loss and pocket depth > 5 mm. The control group comprised 25 volunteers with healthy gingiva, gingival sulcus  lt  2 mm and no attachment loss. The presence of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in subgingival plaque samples was analysed by the polymerase chain reaction (PCR) method. The periodontal parameters and CRP levels were significantly higher in the patients with periodontitis. Patients who had severe periodontitis, with high levels of mean clinical attachment loss, and subjects with moderate periodontitis had higher mean CRP levels. The percentage of subjects with elevated levels of CRP > 5 mg/l was greater in the higher clinical attachment loss group compared to the group with lower attachment loss. The presence of P. gingivalis and A. actinomycetemcomitans were also associated with elevated CRP levels and poor periodontal status. Periodontitis and the presence of P. gingivalis are associated with an enhanced inflammatory response expressed by higher CRP levels. The association of periodontitis with CRP levels appears to be a contributing factor for CVD and might be a possible intermediate pathway in this association.
PB  - Springer, New York
T2  - European Journal of Clinical Microbiology & Infectious Diseases
T1  - C-reactive protein as a systemic marker of inflammation in periodontitis
VL  - 30
IS  - 3
SP  - 407
EP  - 414
DO  - 10.1007/s10096-010-1101-1
ER  - 

@article{
author = "Pejčić, Nataša and Kesić, Ljiljana and Milašin, Jelena",
year = "2011",
abstract = "Periodontitis has been identified as a potential risk factor for systemic pathologies such as cardiovascular disease (CVD). The aims of this investigation were to assess the relationship between periodontitis and systemic inflammatory factor, as well as to discover whether there is a relation to the severity of periodontitis and to the periodontopathogens. Periodontal examinations and serum C-reactive protein (CRP) level measurements were performed in 50 patients with periodontitis. Periodontal health indicators included the gingival bleeding on probing index and periodontal disease status. The patients with moderate periodontitis had low attachment loss and pocket depth  lt  4 mm. The patients with severe periodontitis had high attachment loss and pocket depth > 5 mm. The control group comprised 25 volunteers with healthy gingiva, gingival sulcus  lt  2 mm and no attachment loss. The presence of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in subgingival plaque samples was analysed by the polymerase chain reaction (PCR) method. The periodontal parameters and CRP levels were significantly higher in the patients with periodontitis. Patients who had severe periodontitis, with high levels of mean clinical attachment loss, and subjects with moderate periodontitis had higher mean CRP levels. The percentage of subjects with elevated levels of CRP > 5 mg/l was greater in the higher clinical attachment loss group compared to the group with lower attachment loss. The presence of P. gingivalis and A. actinomycetemcomitans were also associated with elevated CRP levels and poor periodontal status. Periodontitis and the presence of P. gingivalis are associated with an enhanced inflammatory response expressed by higher CRP levels. The association of periodontitis with CRP levels appears to be a contributing factor for CVD and might be a possible intermediate pathway in this association.",
publisher = "Springer, New York",
journal = "European Journal of Clinical Microbiology & Infectious Diseases",
title = "C-reactive protein as a systemic marker of inflammation in periodontitis",
volume = "30",
number = "3",
pages = "407-414",
doi = "10.1007/s10096-010-1101-1"
}

Pejčić, N., Kesić, L.,& Milašin, J.. (2011). C-reactive protein as a systemic marker of inflammation in periodontitis. in European Journal of Clinical Microbiology & Infectious Diseases
Springer, New York., 30(3), 407-414.
https://doi.org/10.1007/s10096-010-1101-1

Pejčić N, Kesić L, Milašin J. C-reactive protein as a systemic marker of inflammation in periodontitis. in European Journal of Clinical Microbiology & Infectious Diseases. 2011;30(3):407-414.
doi:10.1007/s10096-010-1101-1 .

Pejčić, Nataša, Kesić, Ljiljana, Milašin, Jelena, "C-reactive protein as a systemic marker of inflammation in periodontitis" in European Journal of Clinical Microbiology & Infectious Diseases, 30, no. 3 (2011):407-414,
https://doi.org/10.1007/s10096-010-1101-1 . .

TY  - JOUR
AU  - Igić, Marija
AU  - Mihailović, Dragan
AU  - Kesić, Ljiljana
AU  - Apostolović, Mirjana
AU  - Kostadinović, Ljiljana
AU  - Tričković-Janjić, Olivera
AU  - Milašin, Jelena
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1647
AB  - Introduction/Aim. Gingivitis is a common occurrence in children and may well be thought as a risk factor for the appearance and progression of the diseases of parodontal tissues. It is thus necessary to react in a timely and adequate fashion to prevent the disease to become serious and produce parodontopathy. The aim of the study was to establish the efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. Methods. The study enrolled 130 children with permanent dentition. All of the examinees were divided into three groups: group I - 50 patients with chronic gingivitis in which only the basic treatment was applied; group II - 50 patients with chronic gingivitis in which hyaluronic acid was applied in addition to basic treatment; group III - 30 examinees with healthy gingiva (control group). Assessment of oral hygiene and status of the gingiva and parodontium was done using the appropriate indexes before and after the treatment. Inflammation of the gingiva was monitored by way of cytomorphometric studies. Results. The pretreatment values of the plaque index (PI) were high: in the group I PI was 1.94; in the group II PI was 1.68. After the treatment, the PI value was reduced to null in both groups (PI = 0). In the group III PI was 0.17. The bleeding index (BI) in the group I was 2.02 before and 0.32 after the treatment; the BI value in the group II was 1.74 before and 0.16 after the treatment. In the group III BI was 0. In the group I, the Community Periodontal Index of Treatment Needs (CPITN) was 1.66 before and 0.32 after the treatment; in the group II, the CPITN value was 1.5 before and 0.24 after the treatment. In the group III, the CPITN value was 0. In the group I, the size of the nuclei of the stratified squamous epithelium of the gingiva was reduced, although not so much as the nuclear size in the group II of examinees. Conclusion. Basic treatment is able to successfully treat chronic gingivitis in children. The use of hyaluronic acid together with the basic treatment can markedly improve the treatment effect.
AB  - Uvod/Cilj. Gingivitis je česta pojava kod dece i može se smatrati faktorom rizika od nastanka i progresije oboljenja ostalih parodontalnih tkiva. Zato je potrebno blagovremeno i adekvatno reagovati kako ne bi došlo do progresije bolesti i nastanka parodontopatije. Cilj rada bio je da se utvrdi efikasnost primene hijaluronske kiseline u terapiji hroničnih gingivitisa kod dece. Metode. Ispitivanjem je bilo obuhvaćeno 130 dece sa stalnom denticijom. Svi ispitanici bili su podeljeni u tri grupe: grupa I - 50 ispitanika sa hroničnim gingivitisom kod kojih je primenjena samo bazična terapija; grupa II - 50 ispitanika sa hroničnim gingivitisom, kod kojih je uz bazičnu terapiju primenjena i terapija hijaluronskom kiselinom; grupa III - 30 ispitanika sa zdravom gingivom (kontrolna grupa). Procena stanja oralne higijene, stanja zdravlja gingive i parodoncijuma vršena je uz pomoć odgovarajućih indeksa pre i posle terapije. Inflamacija gingive praćena je citomorfometrijskim ispitivanjima. Rezultati. Pre terapije, vrednosti indeksa plaka (PI) bile su visoke: u grupi I 1,94, a u grupi II 1,68. Nakon terapije u obe grupe vrednosti PI iznosile su 0. U grupi III vrednost PI bila je 0,17. Indeks krvarenja (IKR) u grupi I pre terapije bio je 2,02, a posle terapije 0,32; u grupi II IKR pre terapije bio je 1,74, a posle terapije 0,16. U grupi III IKR bio je 0. U grupi I, pre terapije, Community Periodontal Index of Treatment Needs (CPITN) bio je 1,66, a posle terapije 0,32; u grupi II pre terapije CPITN bio je 1,5, a posle terapije 0,24. U grupi III CPITN indeks bio je 0. Kod ispitanika grupe I nakon terapije citomorfometrijskim ispitivanjem utvrđeno je da je došlo do smanjenja veličine jedara pločasto slojevitog epitela gingive, ali ne u tolikoj meri kao kod ispitanika grupe II. Zaključak. Bazičnom terapijom može se uspešno sanirati hronični gingivitis kod dece. Primena hijaluronske kiseline uz bazičnu terapiju može bitno poboljšati ovaj efekat.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children
T1  - Efikasnost hijaluronske kiseline u terapiji hroničnog gingivitisa kod dece
VL  - 68
IS  - 12
SP  - 1021
EP  - 1025
DO  - 10.2298/VSP1112021I
ER  - 

@article{
author = "Igić, Marija and Mihailović, Dragan and Kesić, Ljiljana and Apostolović, Mirjana and Kostadinović, Ljiljana and Tričković-Janjić, Olivera and Milašin, Jelena",
year = "2011",
abstract = "Introduction/Aim. Gingivitis is a common occurrence in children and may well be thought as a risk factor for the appearance and progression of the diseases of parodontal tissues. It is thus necessary to react in a timely and adequate fashion to prevent the disease to become serious and produce parodontopathy. The aim of the study was to establish the efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. Methods. The study enrolled 130 children with permanent dentition. All of the examinees were divided into three groups: group I - 50 patients with chronic gingivitis in which only the basic treatment was applied; group II - 50 patients with chronic gingivitis in which hyaluronic acid was applied in addition to basic treatment; group III - 30 examinees with healthy gingiva (control group). Assessment of oral hygiene and status of the gingiva and parodontium was done using the appropriate indexes before and after the treatment. Inflammation of the gingiva was monitored by way of cytomorphometric studies. Results. The pretreatment values of the plaque index (PI) were high: in the group I PI was 1.94; in the group II PI was 1.68. After the treatment, the PI value was reduced to null in both groups (PI = 0). In the group III PI was 0.17. The bleeding index (BI) in the group I was 2.02 before and 0.32 after the treatment; the BI value in the group II was 1.74 before and 0.16 after the treatment. In the group III BI was 0. In the group I, the Community Periodontal Index of Treatment Needs (CPITN) was 1.66 before and 0.32 after the treatment; in the group II, the CPITN value was 1.5 before and 0.24 after the treatment. In the group III, the CPITN value was 0. In the group I, the size of the nuclei of the stratified squamous epithelium of the gingiva was reduced, although not so much as the nuclear size in the group II of examinees. Conclusion. Basic treatment is able to successfully treat chronic gingivitis in children. The use of hyaluronic acid together with the basic treatment can markedly improve the treatment effect., Uvod/Cilj. Gingivitis je česta pojava kod dece i može se smatrati faktorom rizika od nastanka i progresije oboljenja ostalih parodontalnih tkiva. Zato je potrebno blagovremeno i adekvatno reagovati kako ne bi došlo do progresije bolesti i nastanka parodontopatije. Cilj rada bio je da se utvrdi efikasnost primene hijaluronske kiseline u terapiji hroničnih gingivitisa kod dece. Metode. Ispitivanjem je bilo obuhvaćeno 130 dece sa stalnom denticijom. Svi ispitanici bili su podeljeni u tri grupe: grupa I - 50 ispitanika sa hroničnim gingivitisom kod kojih je primenjena samo bazična terapija; grupa II - 50 ispitanika sa hroničnim gingivitisom, kod kojih je uz bazičnu terapiju primenjena i terapija hijaluronskom kiselinom; grupa III - 30 ispitanika sa zdravom gingivom (kontrolna grupa). Procena stanja oralne higijene, stanja zdravlja gingive i parodoncijuma vršena je uz pomoć odgovarajućih indeksa pre i posle terapije. Inflamacija gingive praćena je citomorfometrijskim ispitivanjima. Rezultati. Pre terapije, vrednosti indeksa plaka (PI) bile su visoke: u grupi I 1,94, a u grupi II 1,68. Nakon terapije u obe grupe vrednosti PI iznosile su 0. U grupi III vrednost PI bila je 0,17. Indeks krvarenja (IKR) u grupi I pre terapije bio je 2,02, a posle terapije 0,32; u grupi II IKR pre terapije bio je 1,74, a posle terapije 0,16. U grupi III IKR bio je 0. U grupi I, pre terapije, Community Periodontal Index of Treatment Needs (CPITN) bio je 1,66, a posle terapije 0,32; u grupi II pre terapije CPITN bio je 1,5, a posle terapije 0,24. U grupi III CPITN indeks bio je 0. Kod ispitanika grupe I nakon terapije citomorfometrijskim ispitivanjem utvrđeno je da je došlo do smanjenja veličine jedara pločasto slojevitog epitela gingive, ali ne u tolikoj meri kao kod ispitanika grupe II. Zaključak. Bazičnom terapijom može se uspešno sanirati hronični gingivitis kod dece. Primena hijaluronske kiseline uz bazičnu terapiju može bitno poboljšati ovaj efekat.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children, Efikasnost hijaluronske kiseline u terapiji hroničnog gingivitisa kod dece",
volume = "68",
number = "12",
pages = "1021-1025",
doi = "10.2298/VSP1112021I"
}

Igić, M., Mihailović, D., Kesić, L., Apostolović, M., Kostadinović, L., Tričković-Janjić, O.,& Milašin, J.. (2011). Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 68(12), 1021-1025.
https://doi.org/10.2298/VSP1112021I

Igić M, Mihailović D, Kesić L, Apostolović M, Kostadinović L, Tričković-Janjić O, Milašin J. Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. in Vojnosanitetski pregled. 2011;68(12):1021-1025.
doi:10.2298/VSP1112021I .

Igić, Marija, Mihailović, Dragan, Kesić, Ljiljana, Apostolović, Mirjana, Kostadinović, Ljiljana, Tričković-Janjić, Olivera, Milašin, Jelena, "Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children" in Vojnosanitetski pregled, 68, no. 12 (2011):1021-1025,
https://doi.org/10.2298/VSP1112021I . .

TY  - JOUR
AU  - Kesić, Ljiljana
AU  - Milašin, Jelena
AU  - Igić, Marija
AU  - Obradović, Radmila
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1380
AB  - The periodontal disease is a chronic, degenerative disease which is localised on the gingiva, periodontal ligament, cementum and alveolar bone. The main etiological factor is oral biofilm with microorganisms. The search for the pathogens of periodontal diseases has been underway for more than 100 years, and continues up today. The currently recognized key Gram negative periodontopathogens include: Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Capnocytophaga species, Campylobacter rectus.All bacteria in the periodontal pocket could damage periodontal tissues, and good knowledge of these as well as an adequate treatment could be helpful in treatment of this disease. A full understanding of the microbial factors, their pathogenicity as well as host factors are of the essential importance for pathogenesis of periodontal disease. In this way, it could be possible to treat the periodontal patients adequately.
AB  - Parodontopatija predstavlja hroničnu, destruktivnu bolest, koja zahvata čitav potporni aparat zuba (gingiva, cement, alveolarna kost i periodoncijum). Glavni etiološki faktor u nastanku ovog oboljenja je oralni biofilm sa mikroorganizmima. Poslednjih 100 godina istraživači ispituju sastav mikrobiološke flore parodontalnog džepa. Do danas ključni Gram negativni periodontopatogeni su: Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Capnocytophaga species, Campylobacter rectus. Sve prisutne bakterije u parodontalnom džepu mogu oštetiti parodontalna tkiva, i dobro poznavanje mikroorganizama omogućava i adekvatan tretman parodontopatije. Potpuno poznavanje mikroroganizama, njihove patogenosti, kao i poznavanje odgovora domaćina su osnovni za razumevanje patogeneze parodontopatije. ovo bi omogućilo i lečenje pacijenata sa parodontopatijom na odgovarajući način.
PB  - Univerzitet u Nišu, Niš
T2  - Facta universitatis - series: Medicine & Biology
T1  - Microbial etiology of periodontal disease: Mini review
T1  - Mikrobiološka etiologija parodontopatije
VL  - 15
IS  - 1
SP  - 1
EP  - 6
UR  - https://hdl.handle.net/21.15107/rcub_smile_1380
ER  - 

@article{
author = "Kesić, Ljiljana and Milašin, Jelena and Igić, Marija and Obradović, Radmila",
year = "2008",
abstract = "The periodontal disease is a chronic, degenerative disease which is localised on the gingiva, periodontal ligament, cementum and alveolar bone. The main etiological factor is oral biofilm with microorganisms. The search for the pathogens of periodontal diseases has been underway for more than 100 years, and continues up today. The currently recognized key Gram negative periodontopathogens include: Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Capnocytophaga species, Campylobacter rectus.All bacteria in the periodontal pocket could damage periodontal tissues, and good knowledge of these as well as an adequate treatment could be helpful in treatment of this disease. A full understanding of the microbial factors, their pathogenicity as well as host factors are of the essential importance for pathogenesis of periodontal disease. In this way, it could be possible to treat the periodontal patients adequately., Parodontopatija predstavlja hroničnu, destruktivnu bolest, koja zahvata čitav potporni aparat zuba (gingiva, cement, alveolarna kost i periodoncijum). Glavni etiološki faktor u nastanku ovog oboljenja je oralni biofilm sa mikroorganizmima. Poslednjih 100 godina istraživači ispituju sastav mikrobiološke flore parodontalnog džepa. Do danas ključni Gram negativni periodontopatogeni su: Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Capnocytophaga species, Campylobacter rectus. Sve prisutne bakterije u parodontalnom džepu mogu oštetiti parodontalna tkiva, i dobro poznavanje mikroorganizama omogućava i adekvatan tretman parodontopatije. Potpuno poznavanje mikroroganizama, njihove patogenosti, kao i poznavanje odgovora domaćina su osnovni za razumevanje patogeneze parodontopatije. ovo bi omogućilo i lečenje pacijenata sa parodontopatijom na odgovarajući način.",
publisher = "Univerzitet u Nišu, Niš",
journal = "Facta universitatis - series: Medicine & Biology",
title = "Microbial etiology of periodontal disease: Mini review, Mikrobiološka etiologija parodontopatije",
volume = "15",
number = "1",
pages = "1-6",
url = "https://hdl.handle.net/21.15107/rcub_smile_1380"
}

Kesić, L., Milašin, J., Igić, M.,& Obradović, R.. (2008). Microbial etiology of periodontal disease: Mini review. in Facta universitatis - series: Medicine & Biology
Univerzitet u Nišu, Niš., 15(1), 1-6.
https://hdl.handle.net/21.15107/rcub_smile_1380

Kesić L, Milašin J, Igić M, Obradović R. Microbial etiology of periodontal disease: Mini review. in Facta universitatis - series: Medicine & Biology. 2008;15(1):1-6.
https://hdl.handle.net/21.15107/rcub_smile_1380 .

Kesić, Ljiljana, Milašin, Jelena, Igić, Marija, Obradović, Radmila, "Microbial etiology of periodontal disease: Mini review" in Facta universitatis - series: Medicine & Biology, 15, no. 1 (2008):1-6,
https://hdl.handle.net/21.15107/rcub_smile_1380 .