TY  - JOUR
AU  - Jeremić, Vasilije
AU  - Alempijević, Tamara
AU  - Mijatović, Srđan
AU  - Sijacki, Ana
AU  - Dragašević, Sanja
AU  - Pavlović, Sonja
AU  - Miličić, Biljana
AU  - Krstić, Slobodan
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1884
AB  - In polytrauma, injuries that may be surgically treated under regular circumstances due to a systemic inflammatory response become life-threatening. The inflammatory response involves a complex pattern of humoral and cellular responses and the expression of related factors is thought to be governed by genetic variations. This aim of this paper is to examine the influence of interleukin (IL) 6 single nucleotide polymorphism (SNP) -174C/G and -596G/A on the treatment outcome in severely injured patients. Forty-seven severely injured patients were included in this study. Patients were assigned an Injury Severity Score. Blood samples were drawn within 24 h after admission (designated day 1) and on subsequent days (24, 48, 72, hours and 7days) of hospitalization. The IL-6 levels were determined through ELSA technique. Polymorphisms were analyzed by a method of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR). Among subjects with different outcomes, no statistically relevant difference was found with regards to the gene IL-6 SNP-174G/C polymorphism. More than a half of subjects who died had the SNP-174G/C polymorphism, while this polymorphism was represented in a slightly lower number in survivors. The incidence of subjects without polymorphism and those with heterozygous and homozygous gene IL-6 SNP-596G/A polymorphism did not present statistically significant variations between survivors and those who died. The levels of IL-6 over the observation period did not present any statistically relevant difference among subjects without the IL-6 SNP-174 or IL- 6 SNP -596 gene polymorphism and those who had either a heterozygous or a homozygous polymorphism.
PB  - Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa
T2  - Bosnian Journal of Basic Medical Sciences
T1  - Clinical relevance of IL-6 gene polymorphism in severely injured patients
VL  - 14
IS  - 2
SP  - 110
EP  - 117
DO  - 10.17305/bjbms.2014.2274
ER  - 

@article{
author = "Jeremić, Vasilije and Alempijević, Tamara and Mijatović, Srđan and Sijacki, Ana and Dragašević, Sanja and Pavlović, Sonja and Miličić, Biljana and Krstić, Slobodan",
year = "2014",
abstract = "In polytrauma, injuries that may be surgically treated under regular circumstances due to a systemic inflammatory response become life-threatening. The inflammatory response involves a complex pattern of humoral and cellular responses and the expression of related factors is thought to be governed by genetic variations. This aim of this paper is to examine the influence of interleukin (IL) 6 single nucleotide polymorphism (SNP) -174C/G and -596G/A on the treatment outcome in severely injured patients. Forty-seven severely injured patients were included in this study. Patients were assigned an Injury Severity Score. Blood samples were drawn within 24 h after admission (designated day 1) and on subsequent days (24, 48, 72, hours and 7days) of hospitalization. The IL-6 levels were determined through ELSA technique. Polymorphisms were analyzed by a method of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR). Among subjects with different outcomes, no statistically relevant difference was found with regards to the gene IL-6 SNP-174G/C polymorphism. More than a half of subjects who died had the SNP-174G/C polymorphism, while this polymorphism was represented in a slightly lower number in survivors. The incidence of subjects without polymorphism and those with heterozygous and homozygous gene IL-6 SNP-596G/A polymorphism did not present statistically significant variations between survivors and those who died. The levels of IL-6 over the observation period did not present any statistically relevant difference among subjects without the IL-6 SNP-174 or IL- 6 SNP -596 gene polymorphism and those who had either a heterozygous or a homozygous polymorphism.",
publisher = "Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa",
journal = "Bosnian Journal of Basic Medical Sciences",
title = "Clinical relevance of IL-6 gene polymorphism in severely injured patients",
volume = "14",
number = "2",
pages = "110-117",
doi = "10.17305/bjbms.2014.2274"
}

Jeremić, V., Alempijević, T., Mijatović, S., Sijacki, A., Dragašević, S., Pavlović, S., Miličić, B.,& Krstić, S.. (2014). Clinical relevance of IL-6 gene polymorphism in severely injured patients. in Bosnian Journal of Basic Medical Sciences
Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa., 14(2), 110-117.
https://doi.org/10.17305/bjbms.2014.2274

Jeremić V, Alempijević T, Mijatović S, Sijacki A, Dragašević S, Pavlović S, Miličić B, Krstić S. Clinical relevance of IL-6 gene polymorphism in severely injured patients. in Bosnian Journal of Basic Medical Sciences. 2014;14(2):110-117.
doi:10.17305/bjbms.2014.2274 .

Jeremić, Vasilije, Alempijević, Tamara, Mijatović, Srđan, Sijacki, Ana, Dragašević, Sanja, Pavlović, Sonja, Miličić, Biljana, Krstić, Slobodan, "Clinical relevance of IL-6 gene polymorphism in severely injured patients" in Bosnian Journal of Basic Medical Sciences, 14, no. 2 (2014):110-117,
https://doi.org/10.17305/bjbms.2014.2274 . .

TY  - JOUR
AU  - Alempijević, Tamara
AU  - Sokić-Milutinović, Aleksandra
AU  - Pavlović-Marković, Aleksandra
AU  - Jesic-Vukicević, Rada
AU  - Miličić, Biljana
AU  - Macut, Đuro
AU  - Popović, Dragan
AU  - Tomić, Dragan
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1740
AB  - Primary biliary cirrhosis (PBC) is a chronic, progressive liver disease with elevated serum lipids. It remains unclear if hyperlipidemia increases the risk for atherosclerosis in PBC patients. Metabolic syndrome (MS) promotes the development of atherosclerotic cardiovascular disease due to abdominal obesity and insulin resistance. The aim of this study was to assess incidence and parameters of MS, as well as subcutaneous and visceral fat using noninvasive ultrasonographic measurement in patients with PBC in our population. We included 55 patients with PBC and 44 age- and sex-matched healthy controls (CG-control group). Anthropometric measurements (weight, height, and waist circumference), age, sex, and body mass index were recorded for patients and controls. Laboratory tests for assessing MS and liver function tests were analyzed. We used ultrasonography to determine subcutaneous and visceral fat diameter and area (SF, VF and SA, VA, respectively), as well as perirenal fat diameter (PF). Patients with PBC had significantly higher levels of cholesterol and liver function tests. There were no statistically significant difference in serum insulin and HOMA levels, as well as incidence of MS was diagnosed in 30.9 % (17/55) PBC patients and 43.2 % (19/44) controls. We registered lower amount of VF (PBC:10.92 +/- 3.63 mm, CG:16.84 +/- 5.51 mm,  lt  0.001), VA (PBC:403.64 +/- 166.97 mm(2), CG:720.57 +/- 272.50 mm(2),  lt  0.001), and PF (PBC:7.03 +/- 1.82 mm, CG 10.49 +/- 2.70 mm,  lt  0.001) in patients with PBC. MS is not more frequent in patients with PBC compared with healthy volunteers in our population. Lower amount of VF could be related to lower risk for cardiovascular events in PBC patients.
PB  - Springer Wien, Wien
T2  - Wiener Klinische Wochenschrift
T1  - Assessment of metabolic syndrome in patients with primary biliary cirrhosis
VL  - 124
IS  - 7-8
SP  - 251
EP  - 255
DO  - 10.1007/s00508-012-0162-9
ER  - 

@article{
author = "Alempijević, Tamara and Sokić-Milutinović, Aleksandra and Pavlović-Marković, Aleksandra and Jesic-Vukicević, Rada and Miličić, Biljana and Macut, Đuro and Popović, Dragan and Tomić, Dragan",
year = "2012",
abstract = "Primary biliary cirrhosis (PBC) is a chronic, progressive liver disease with elevated serum lipids. It remains unclear if hyperlipidemia increases the risk for atherosclerosis in PBC patients. Metabolic syndrome (MS) promotes the development of atherosclerotic cardiovascular disease due to abdominal obesity and insulin resistance. The aim of this study was to assess incidence and parameters of MS, as well as subcutaneous and visceral fat using noninvasive ultrasonographic measurement in patients with PBC in our population. We included 55 patients with PBC and 44 age- and sex-matched healthy controls (CG-control group). Anthropometric measurements (weight, height, and waist circumference), age, sex, and body mass index were recorded for patients and controls. Laboratory tests for assessing MS and liver function tests were analyzed. We used ultrasonography to determine subcutaneous and visceral fat diameter and area (SF, VF and SA, VA, respectively), as well as perirenal fat diameter (PF). Patients with PBC had significantly higher levels of cholesterol and liver function tests. There were no statistically significant difference in serum insulin and HOMA levels, as well as incidence of MS was diagnosed in 30.9 % (17/55) PBC patients and 43.2 % (19/44) controls. We registered lower amount of VF (PBC:10.92 +/- 3.63 mm, CG:16.84 +/- 5.51 mm,  lt  0.001), VA (PBC:403.64 +/- 166.97 mm(2), CG:720.57 +/- 272.50 mm(2),  lt  0.001), and PF (PBC:7.03 +/- 1.82 mm, CG 10.49 +/- 2.70 mm,  lt  0.001) in patients with PBC. MS is not more frequent in patients with PBC compared with healthy volunteers in our population. Lower amount of VF could be related to lower risk for cardiovascular events in PBC patients.",
publisher = "Springer Wien, Wien",
journal = "Wiener Klinische Wochenschrift",
title = "Assessment of metabolic syndrome in patients with primary biliary cirrhosis",
volume = "124",
number = "7-8",
pages = "251-255",
doi = "10.1007/s00508-012-0162-9"
}

Alempijević, T., Sokić-Milutinović, A., Pavlović-Marković, A., Jesic-Vukicević, R., Miličić, B., Macut, Đ., Popović, D.,& Tomić, D.. (2012). Assessment of metabolic syndrome in patients with primary biliary cirrhosis. in Wiener Klinische Wochenschrift
Springer Wien, Wien., 124(7-8), 251-255.
https://doi.org/10.1007/s00508-012-0162-9

Alempijević T, Sokić-Milutinović A, Pavlović-Marković A, Jesic-Vukicević R, Miličić B, Macut Đ, Popović D, Tomić D. Assessment of metabolic syndrome in patients with primary biliary cirrhosis. in Wiener Klinische Wochenschrift. 2012;124(7-8):251-255.
doi:10.1007/s00508-012-0162-9 .

Alempijević, Tamara, Sokić-Milutinović, Aleksandra, Pavlović-Marković, Aleksandra, Jesic-Vukicević, Rada, Miličić, Biljana, Macut, Đuro, Popović, Dragan, Tomić, Dragan, "Assessment of metabolic syndrome in patients with primary biliary cirrhosis" in Wiener Klinische Wochenschrift, 124, no. 7-8 (2012):251-255,
https://doi.org/10.1007/s00508-012-0162-9 . .

TY  - JOUR
AU  - Alempijević, Tamara
AU  - Sokić-Milutinović, Aleksandra
AU  - Miličić, Biljana
AU  - Jesić, Rada
AU  - Balović, Ana
AU  - Popović, Dragan
AU  - Krstić, Miodrag
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1712
AB  - Background/aims: Portal hypertension and development of esophageal varices is one of the major complications of liver cirrhosis. The aim of our study was to evaluate the possibility of the presence of esophageal varices and their size using biochemical and ultrasonography parameters in patients with alcoholic liver cirrhosis. Material and Methods: We included in our study 86 patients (74 males, mean age 55 +/- 7) with alcoholic liver cirrhosis. The control group consisted of 102 patients with cirrhosis of other etiologies. All patients underwent a complete biochemical work up, upper digestive endoscopy and ultrasonography examination. The right liver lobe diameter/albumin and platelet count/spleen diameter ratios were calculated. The correlation of the calculated ratios with the presence and degree of esophageal varices in patients with liver cirrhosis was also determined. Results: The mean value of right liver lobe diameter-albumin ratio was 6.15 +/- 1.77, and statistically significantly differed from values determined in the control group (4.97 +/- 1.68). The mean platelet count-spleen diameter ratio was 972.5 +/- 599.0 in alcoholic liver cirrhosis and 1055.9 +/- 821.3 in controls (p>0.05). In patients with alcoholic liver cirrhosis, none of the analyzed noninvasive markers was shown to be a good predictor of the presence and size of esophageal varices. Conclusions: Despite the important role of noninvasive markers in providing information pertinent to determination of esophageal varices in patients with liver cirrhosis, these markers have limited relevance in patients with alcoholic cirrhosis.
PB  - Turkish Soc Gastroenterology, Abidinpasa
T2  - Turkish Journal of Gastroenterology
T1  - Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis
VL  - 23
IS  - 3
SP  - 239
EP  - 246
DO  - 10.4318/tjg.2012.0463
ER  - 

@article{
author = "Alempijević, Tamara and Sokić-Milutinović, Aleksandra and Miličić, Biljana and Jesić, Rada and Balović, Ana and Popović, Dragan and Krstić, Miodrag",
year = "2012",
abstract = "Background/aims: Portal hypertension and development of esophageal varices is one of the major complications of liver cirrhosis. The aim of our study was to evaluate the possibility of the presence of esophageal varices and their size using biochemical and ultrasonography parameters in patients with alcoholic liver cirrhosis. Material and Methods: We included in our study 86 patients (74 males, mean age 55 +/- 7) with alcoholic liver cirrhosis. The control group consisted of 102 patients with cirrhosis of other etiologies. All patients underwent a complete biochemical work up, upper digestive endoscopy and ultrasonography examination. The right liver lobe diameter/albumin and platelet count/spleen diameter ratios were calculated. The correlation of the calculated ratios with the presence and degree of esophageal varices in patients with liver cirrhosis was also determined. Results: The mean value of right liver lobe diameter-albumin ratio was 6.15 +/- 1.77, and statistically significantly differed from values determined in the control group (4.97 +/- 1.68). The mean platelet count-spleen diameter ratio was 972.5 +/- 599.0 in alcoholic liver cirrhosis and 1055.9 +/- 821.3 in controls (p>0.05). In patients with alcoholic liver cirrhosis, none of the analyzed noninvasive markers was shown to be a good predictor of the presence and size of esophageal varices. Conclusions: Despite the important role of noninvasive markers in providing information pertinent to determination of esophageal varices in patients with liver cirrhosis, these markers have limited relevance in patients with alcoholic cirrhosis.",
publisher = "Turkish Soc Gastroenterology, Abidinpasa",
journal = "Turkish Journal of Gastroenterology",
title = "Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis",
volume = "23",
number = "3",
pages = "239-246",
doi = "10.4318/tjg.2012.0463"
}

Alempijević, T., Sokić-Milutinović, A., Miličić, B., Jesić, R., Balović, A., Popović, D.,& Krstić, M.. (2012). Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis. in Turkish Journal of Gastroenterology
Turkish Soc Gastroenterology, Abidinpasa., 23(3), 239-246.
https://doi.org/10.4318/tjg.2012.0463

Alempijević T, Sokić-Milutinović A, Miličić B, Jesić R, Balović A, Popović D, Krstić M. Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis. in Turkish Journal of Gastroenterology. 2012;23(3):239-246.
doi:10.4318/tjg.2012.0463 .

Alempijević, Tamara, Sokić-Milutinović, Aleksandra, Miličić, Biljana, Jesić, Rada, Balović, Ana, Popović, Dragan, Krstić, Miodrag, "Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis" in Turkish Journal of Gastroenterology, 23, no. 3 (2012):239-246,
https://doi.org/10.4318/tjg.2012.0463 . .

TY  - JOUR
AU  - Lukić, Snezana
AU  - Nikolić, Aleksandra
AU  - Alempijević, Tamara
AU  - Popović, Dragan
AU  - Sokić-Milutinović, Aleksandra
AU  - Ugljesić, Milenko
AU  - Knežević, Srbislav
AU  - Miličić, Biljana
AU  - Dinić, Dragica
AU  - Radojković, Dragica
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1613
AB  - The purpose of this study was to determine the frequency of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and to investigate its role as a potential risk factor in patients with chronic pancreatitis and pancreatic cancer. Deletion polymorphism of the 287-bp fragment of intron 16 of the ACE gene results in higher levels of circulating enzyme and therefore may represent a risk factor for disease development. The study included 55 patients with chronic pancreatitis, 45 patients with pancreatic cancer and 128 healthy subjects. The presence of I and D variants in the ACE gene was analyzed by a polymerase chain reaction (PCR) method. Distribution of ACE ID genotypes was analyzed by means of logistic regression. When chronic pancreatitis and pancreatic cancer groups were compared in the univariate analysis, the following factors were identified as statistically significant predictors of pancreatic disease: age, gender, smoking, fat intake, ACE II genotype and ACE DD genotype. However, in the multivariate analysis, only age, gender and smoking were singled out as predictors for the occurrence of pancreatic disease. Our findings indicate that the ACE I/D polymorphism could play a role in the development of chronic pancreatitis and pancreatic cancer through interaction with other genetic and environmental factors.
PB  - Karger, Basel
T2  - Digestive Surgery
T1  - Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer
VL  - 28
IS  - 4
SP  - 258
EP  - 262
DO  - 10.1159/000328666
ER  - 

@article{
author = "Lukić, Snezana and Nikolić, Aleksandra and Alempijević, Tamara and Popović, Dragan and Sokić-Milutinović, Aleksandra and Ugljesić, Milenko and Knežević, Srbislav and Miličić, Biljana and Dinić, Dragica and Radojković, Dragica",
year = "2011",
abstract = "The purpose of this study was to determine the frequency of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and to investigate its role as a potential risk factor in patients with chronic pancreatitis and pancreatic cancer. Deletion polymorphism of the 287-bp fragment of intron 16 of the ACE gene results in higher levels of circulating enzyme and therefore may represent a risk factor for disease development. The study included 55 patients with chronic pancreatitis, 45 patients with pancreatic cancer and 128 healthy subjects. The presence of I and D variants in the ACE gene was analyzed by a polymerase chain reaction (PCR) method. Distribution of ACE ID genotypes was analyzed by means of logistic regression. When chronic pancreatitis and pancreatic cancer groups were compared in the univariate analysis, the following factors were identified as statistically significant predictors of pancreatic disease: age, gender, smoking, fat intake, ACE II genotype and ACE DD genotype. However, in the multivariate analysis, only age, gender and smoking were singled out as predictors for the occurrence of pancreatic disease. Our findings indicate that the ACE I/D polymorphism could play a role in the development of chronic pancreatitis and pancreatic cancer through interaction with other genetic and environmental factors.",
publisher = "Karger, Basel",
journal = "Digestive Surgery",
title = "Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer",
volume = "28",
number = "4",
pages = "258-262",
doi = "10.1159/000328666"
}

Lukić, S., Nikolić, A., Alempijević, T., Popović, D., Sokić-Milutinović, A., Ugljesić, M., Knežević, S., Miličić, B., Dinić, D.,& Radojković, D.. (2011). Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer. in Digestive Surgery
Karger, Basel., 28(4), 258-262.
https://doi.org/10.1159/000328666

Lukić S, Nikolić A, Alempijević T, Popović D, Sokić-Milutinović A, Ugljesić M, Knežević S, Miličić B, Dinić D, Radojković D. Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer. in Digestive Surgery. 2011;28(4):258-262.
doi:10.1159/000328666 .

Lukić, Snezana, Nikolić, Aleksandra, Alempijević, Tamara, Popović, Dragan, Sokić-Milutinović, Aleksandra, Ugljesić, Milenko, Knežević, Srbislav, Miličić, Biljana, Dinić, Dragica, Radojković, Dragica, "Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer" in Digestive Surgery, 28, no. 4 (2011):258-262,
https://doi.org/10.1159/000328666 . .