TY  - JOUR
AU  - Jeremić, Vasilije
AU  - Alempijević, Tamara
AU  - Mijatović, Srđan
AU  - Sijacki, Ana
AU  - Dragašević, Sanja
AU  - Pavlović, Sonja
AU  - Miličić, Biljana
AU  - Krstić, Slobodan
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1884
AB  - In polytrauma, injuries that may be surgically treated under regular circumstances due to a systemic inflammatory response become life-threatening. The inflammatory response involves a complex pattern of humoral and cellular responses and the expression of related factors is thought to be governed by genetic variations. This aim of this paper is to examine the influence of interleukin (IL) 6 single nucleotide polymorphism (SNP) -174C/G and -596G/A on the treatment outcome in severely injured patients. Forty-seven severely injured patients were included in this study. Patients were assigned an Injury Severity Score. Blood samples were drawn within 24 h after admission (designated day 1) and on subsequent days (24, 48, 72, hours and 7days) of hospitalization. The IL-6 levels were determined through ELSA technique. Polymorphisms were analyzed by a method of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR). Among subjects with different outcomes, no statistically relevant difference was found with regards to the gene IL-6 SNP-174G/C polymorphism. More than a half of subjects who died had the SNP-174G/C polymorphism, while this polymorphism was represented in a slightly lower number in survivors. The incidence of subjects without polymorphism and those with heterozygous and homozygous gene IL-6 SNP-596G/A polymorphism did not present statistically significant variations between survivors and those who died. The levels of IL-6 over the observation period did not present any statistically relevant difference among subjects without the IL-6 SNP-174 or IL- 6 SNP -596 gene polymorphism and those who had either a heterozygous or a homozygous polymorphism.
PB  - Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa
T2  - Bosnian Journal of Basic Medical Sciences
T1  - Clinical relevance of IL-6 gene polymorphism in severely injured patients
VL  - 14
IS  - 2
SP  - 110
EP  - 117
DO  - 10.17305/bjbms.2014.2274
ER  - 

@article{
author = "Jeremić, Vasilije and Alempijević, Tamara and Mijatović, Srđan and Sijacki, Ana and Dragašević, Sanja and Pavlović, Sonja and Miličić, Biljana and Krstić, Slobodan",
year = "2014",
abstract = "In polytrauma, injuries that may be surgically treated under regular circumstances due to a systemic inflammatory response become life-threatening. The inflammatory response involves a complex pattern of humoral and cellular responses and the expression of related factors is thought to be governed by genetic variations. This aim of this paper is to examine the influence of interleukin (IL) 6 single nucleotide polymorphism (SNP) -174C/G and -596G/A on the treatment outcome in severely injured patients. Forty-seven severely injured patients were included in this study. Patients were assigned an Injury Severity Score. Blood samples were drawn within 24 h after admission (designated day 1) and on subsequent days (24, 48, 72, hours and 7days) of hospitalization. The IL-6 levels were determined through ELSA technique. Polymorphisms were analyzed by a method of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR). Among subjects with different outcomes, no statistically relevant difference was found with regards to the gene IL-6 SNP-174G/C polymorphism. More than a half of subjects who died had the SNP-174G/C polymorphism, while this polymorphism was represented in a slightly lower number in survivors. The incidence of subjects without polymorphism and those with heterozygous and homozygous gene IL-6 SNP-596G/A polymorphism did not present statistically significant variations between survivors and those who died. The levels of IL-6 over the observation period did not present any statistically relevant difference among subjects without the IL-6 SNP-174 or IL- 6 SNP -596 gene polymorphism and those who had either a heterozygous or a homozygous polymorphism.",
publisher = "Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa",
journal = "Bosnian Journal of Basic Medical Sciences",
title = "Clinical relevance of IL-6 gene polymorphism in severely injured patients",
volume = "14",
number = "2",
pages = "110-117",
doi = "10.17305/bjbms.2014.2274"
}

Jeremić, V., Alempijević, T., Mijatović, S., Sijacki, A., Dragašević, S., Pavlović, S., Miličić, B.,& Krstić, S.. (2014). Clinical relevance of IL-6 gene polymorphism in severely injured patients. in Bosnian Journal of Basic Medical Sciences
Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa., 14(2), 110-117.
https://doi.org/10.17305/bjbms.2014.2274

Jeremić V, Alempijević T, Mijatović S, Sijacki A, Dragašević S, Pavlović S, Miličić B, Krstić S. Clinical relevance of IL-6 gene polymorphism in severely injured patients. in Bosnian Journal of Basic Medical Sciences. 2014;14(2):110-117.
doi:10.17305/bjbms.2014.2274 .

Jeremić, Vasilije, Alempijević, Tamara, Mijatović, Srđan, Sijacki, Ana, Dragašević, Sanja, Pavlović, Sonja, Miličić, Biljana, Krstić, Slobodan, "Clinical relevance of IL-6 gene polymorphism in severely injured patients" in Bosnian Journal of Basic Medical Sciences, 14, no. 2 (2014):110-117,
https://doi.org/10.17305/bjbms.2014.2274 . .