TY  - JOUR
AU  - Leković, Vojislav
AU  - Milinković, Iva
AU  - Aleksić, Zoran
AU  - Janković, Saša
AU  - Stanković, P.
AU  - Kenney, Barrie
AU  - Camargo, Paulo
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1762
AB  - Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, Camargo PM. Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodont Res 2012; 47: 409417. (c) 2011 John Wiley & Sons A/S Background and Objective: Bovine porous bone mineral (BPBM) is a xenograft that has been successfully utilized in periodontal regeneration. Platelet-rich fibrin (PRF) is a leukocyte and platelet preparation that concentrates various polypeptide growth factors and therefore has the potential to be used as regenerative treatment for periodontal defects. The purpose of this study was to examine the suitability of autologous PRF as regenerative treatment for periodontal intrabony defects in humans and to examine the ability of BPBM to augment the regenerative effects exerted by PRF. Material and Methods: Using a split-mouth design, 17 paired intrabony defects were randomly treated either with PRF or with PRFBPBM combination. Re-entry surgeries were performed at 6 mo. Primary study outcomes were changes in pocket depth, attachment level and defect fill. Results: Preoperative pocket depths, attachment levels and transoperative bone measurements were similar for the PRF and PRFBPBM groups. Postsurgical measurements revealed a significantly greater reduction in pocket depth in the PRFBPBM group (4.47 +/- 0.78 mm on buccal and 4.29 +/- 0.82 mm on lingual sites) when compared with the PRF group (3.35 +/- 0.68 mm on buccal and 3.24 +/- 0.73 mm on lingual sites). The PRFBPBM group presented with significantly greater attachment gain (3.82 +/- 0.78 mm on buccal and 3.71 +/- 0.75 mm on lingual sites) than the PRF group (2.24 +/- 0.73 mm on buccal and 2.12 +/- 0.68 mm on lingual sites). Defect fill was also greater in the PRFBPBM group (4.06 +/- 0.87 mm on buccal and 3.94 +/- 0.73 mm on lingual sites) than in the PRF group (2.21 +/- 0.68 mm on buccal and 2.06 +/- 0.64 mm on lingual sites). Conclusion: The results of this study indicate that PRF can improve clinical parameters associated with human intrabony periodontal defects, and BPBM has the ability to augment the effects of PRF in reducing pocket depth, improving clinical attachment levels and promoting defect fill.
PB  - Wiley, Hoboken
T2  - Journal of Periodontal Research
T1  - Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects
VL  - 47
IS  - 4
SP  - 409
EP  - 417
DO  - 10.1111/j.1600-0765.2011.01446.x
ER  - 

@article{
author = "Leković, Vojislav and Milinković, Iva and Aleksić, Zoran and Janković, Saša and Stanković, P. and Kenney, Barrie and Camargo, Paulo",
year = "2012",
abstract = "Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, Camargo PM. Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodont Res 2012; 47: 409417. (c) 2011 John Wiley & Sons A/S Background and Objective: Bovine porous bone mineral (BPBM) is a xenograft that has been successfully utilized in periodontal regeneration. Platelet-rich fibrin (PRF) is a leukocyte and platelet preparation that concentrates various polypeptide growth factors and therefore has the potential to be used as regenerative treatment for periodontal defects. The purpose of this study was to examine the suitability of autologous PRF as regenerative treatment for periodontal intrabony defects in humans and to examine the ability of BPBM to augment the regenerative effects exerted by PRF. Material and Methods: Using a split-mouth design, 17 paired intrabony defects were randomly treated either with PRF or with PRFBPBM combination. Re-entry surgeries were performed at 6 mo. Primary study outcomes were changes in pocket depth, attachment level and defect fill. Results: Preoperative pocket depths, attachment levels and transoperative bone measurements were similar for the PRF and PRFBPBM groups. Postsurgical measurements revealed a significantly greater reduction in pocket depth in the PRFBPBM group (4.47 +/- 0.78 mm on buccal and 4.29 +/- 0.82 mm on lingual sites) when compared with the PRF group (3.35 +/- 0.68 mm on buccal and 3.24 +/- 0.73 mm on lingual sites). The PRFBPBM group presented with significantly greater attachment gain (3.82 +/- 0.78 mm on buccal and 3.71 +/- 0.75 mm on lingual sites) than the PRF group (2.24 +/- 0.73 mm on buccal and 2.12 +/- 0.68 mm on lingual sites). Defect fill was also greater in the PRFBPBM group (4.06 +/- 0.87 mm on buccal and 3.94 +/- 0.73 mm on lingual sites) than in the PRF group (2.21 +/- 0.68 mm on buccal and 2.06 +/- 0.64 mm on lingual sites). Conclusion: The results of this study indicate that PRF can improve clinical parameters associated with human intrabony periodontal defects, and BPBM has the ability to augment the effects of PRF in reducing pocket depth, improving clinical attachment levels and promoting defect fill.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontal Research",
title = "Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects",
volume = "47",
number = "4",
pages = "409-417",
doi = "10.1111/j.1600-0765.2011.01446.x"
}

Leković, V., Milinković, I., Aleksić, Z., Janković, S., Stanković, P., Kenney, B.,& Camargo, P.. (2012). Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. in Journal of Periodontal Research
Wiley, Hoboken., 47(4), 409-417.
https://doi.org/10.1111/j.1600-0765.2011.01446.x

Leković V, Milinković I, Aleksić Z, Janković S, Stanković P, Kenney B, Camargo P. Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. in Journal of Periodontal Research. 2012;47(4):409-417.
doi:10.1111/j.1600-0765.2011.01446.x .

Leković, Vojislav, Milinković, Iva, Aleksić, Zoran, Janković, Saša, Stanković, P., Kenney, Barrie, Camargo, Paulo, "Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects" in Journal of Periodontal Research, 47, no. 4 (2012):409-417,
https://doi.org/10.1111/j.1600-0765.2011.01446.x . .