TY  - JOUR
AU  - Supić, Gordana
AU  - Kozomara, Ružica
AU  - Zeljić, Katarina
AU  - Stanimirović, Dragan
AU  - Magić, Marko
AU  - Surbatović, M.
AU  - Jović, N.
AU  - Magić, Zvonko
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1976
AB  - ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients
VL  - 21
IS  - 4
SP  - 536
EP  - 543
DO  - 10.1111/odi.12318
ER  - 

@article{
author = "Supić, Gordana and Kozomara, Ružica and Zeljić, Katarina and Stanimirović, Dragan and Magić, Marko and Surbatović, M. and Jović, N. and Magić, Zvonko",
year = "2015",
abstract = "ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients",
volume = "21",
number = "4",
pages = "536-543",
doi = "10.1111/odi.12318"
}

Supić, G., Kozomara, R., Zeljić, K., Stanimirović, D., Magić, M., Surbatović, M., Jović, N.,& Magić, Z.. (2015). HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases
Wiley, Hoboken., 21(4), 536-543.
https://doi.org/10.1111/odi.12318

Supić G, Kozomara R, Zeljić K, Stanimirović D, Magić M, Surbatović M, Jović N, Magić Z. HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases. 2015;21(4):536-543.
doi:10.1111/odi.12318 .

Supić, Gordana, Kozomara, Ružica, Zeljić, Katarina, Stanimirović, Dragan, Magić, Marko, Surbatović, M., Jović, N., Magić, Zvonko, "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients" in Oral Diseases, 21, no. 4 (2015):536-543,
https://doi.org/10.1111/odi.12318 . .