TY  - JOUR
AU  - Mladenović, Irena
AU  - Supić, Gordana
AU  - Kozomara, Ružica
AU  - Dodić, Slobodan
AU  - Ivković, Nedeljka
AU  - Milićević, Bojana
AU  - Simić, Ivana
AU  - Magić, Zvonko
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2124
AB  - Aims: To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain. Methods: A total of 90 patients with a diagnosis of painful TMD and 92 matched controls were investigated for the presence of TMD, TMD pain, and psychosocial variables by the Research Diagnostic Criteria for TMD. In a prospective cohort study of 40 subjects who underwent extraction of at least one fully impacted mandibular third molar, subjects had 6 months post-surgery follow-up of postoperative pain. DNA extracted from peripheral blood was genotyped for three COMT polymorphisms (rs4680, rs6269, and rs165774) by real-time TaqMan method. The association between COMT polymorphisms and clinical variables was determined by calculating odds ratios (OR) and their 95% confidence intervals (CO. Results: Homozygous AA genotype and heterozygous variant A allele carriers (genotype AG/AA) for rs165774 polymorphism were associated with increased risk of TMD compared to wild type (wt) GG genotype (OR = 9.448, P =.006; OR = 2.088, P =.017, respectively). In addition, AA genotype was associated with increased risk of arthralgia (OR = 4.448, P =.011), myofascial pain (OR = 3.543, P =.035), and chronic TMD pain (OR = 6.173, P =.006), compared to wt genotype. AA genotype for rs6269 polymorphism was related to less postoperative chronic TMD pain (P =.025) and lower postoperative acute pain at the extraction site (P =.030). No associations with depression and somatization were observed. Conclusion: AA genotype of rs165774 could be a significant risk factor for the development of TMD and TMD pain, while AA genotype of rs6269 presents less postoperative chronic TMD pain and acute pain at a dental extraction site.
PB  - Quintessence Publishing Co Inc, Hanover Park
T2  - Journal of Oral & Facial Pain & Headache
T1  - Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain
VL  - 30
IS  - 4
SP  - 302
EP  - 310
DO  - 10.11607/ofph.1688
ER  - 

@article{
author = "Mladenović, Irena and Supić, Gordana and Kozomara, Ružica and Dodić, Slobodan and Ivković, Nedeljka and Milićević, Bojana and Simić, Ivana and Magić, Zvonko",
year = "2016",
abstract = "Aims: To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain. Methods: A total of 90 patients with a diagnosis of painful TMD and 92 matched controls were investigated for the presence of TMD, TMD pain, and psychosocial variables by the Research Diagnostic Criteria for TMD. In a prospective cohort study of 40 subjects who underwent extraction of at least one fully impacted mandibular third molar, subjects had 6 months post-surgery follow-up of postoperative pain. DNA extracted from peripheral blood was genotyped for three COMT polymorphisms (rs4680, rs6269, and rs165774) by real-time TaqMan method. The association between COMT polymorphisms and clinical variables was determined by calculating odds ratios (OR) and their 95% confidence intervals (CO. Results: Homozygous AA genotype and heterozygous variant A allele carriers (genotype AG/AA) for rs165774 polymorphism were associated with increased risk of TMD compared to wild type (wt) GG genotype (OR = 9.448, P =.006; OR = 2.088, P =.017, respectively). In addition, AA genotype was associated with increased risk of arthralgia (OR = 4.448, P =.011), myofascial pain (OR = 3.543, P =.035), and chronic TMD pain (OR = 6.173, P =.006), compared to wt genotype. AA genotype for rs6269 polymorphism was related to less postoperative chronic TMD pain (P =.025) and lower postoperative acute pain at the extraction site (P =.030). No associations with depression and somatization were observed. Conclusion: AA genotype of rs165774 could be a significant risk factor for the development of TMD and TMD pain, while AA genotype of rs6269 presents less postoperative chronic TMD pain and acute pain at a dental extraction site.",
publisher = "Quintessence Publishing Co Inc, Hanover Park",
journal = "Journal of Oral & Facial Pain & Headache",
title = "Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain",
volume = "30",
number = "4",
pages = "302-310",
doi = "10.11607/ofph.1688"
}

Mladenović, I., Supić, G., Kozomara, R., Dodić, S., Ivković, N., Milićević, B., Simić, I.,& Magić, Z.. (2016). Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain. in Journal of Oral & Facial Pain & Headache
Quintessence Publishing Co Inc, Hanover Park., 30(4), 302-310.
https://doi.org/10.11607/ofph.1688

Mladenović I, Supić G, Kozomara R, Dodić S, Ivković N, Milićević B, Simić I, Magić Z. Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain. in Journal of Oral & Facial Pain & Headache. 2016;30(4):302-310.
doi:10.11607/ofph.1688 .

Mladenović, Irena, Supić, Gordana, Kozomara, Ružica, Dodić, Slobodan, Ivković, Nedeljka, Milićević, Bojana, Simić, Ivana, Magić, Zvonko, "Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain" in Journal of Oral & Facial Pain & Headache, 30, no. 4 (2016):302-310,
https://doi.org/10.11607/ofph.1688 . .

TY  - JOUR
AU  - Supić, Gordana
AU  - Kozomara, Ružica
AU  - Zeljić, Katarina
AU  - Stanimirović, Dragan
AU  - Magić, Marko
AU  - Surbatović, M.
AU  - Jović, N.
AU  - Magić, Zvonko
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1976
AB  - ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients
VL  - 21
IS  - 4
SP  - 536
EP  - 543
DO  - 10.1111/odi.12318
ER  - 

@article{
author = "Supić, Gordana and Kozomara, Ružica and Zeljić, Katarina and Stanimirović, Dragan and Magić, Marko and Surbatović, M. and Jović, N. and Magić, Zvonko",
year = "2015",
abstract = "ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients",
volume = "21",
number = "4",
pages = "536-543",
doi = "10.1111/odi.12318"
}

Supić, G., Kozomara, R., Zeljić, K., Stanimirović, D., Magić, M., Surbatović, M., Jović, N.,& Magić, Z.. (2015). HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases
Wiley, Hoboken., 21(4), 536-543.
https://doi.org/10.1111/odi.12318

Supić G, Kozomara R, Zeljić K, Stanimirović D, Magić M, Surbatović M, Jović N, Magić Z. HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases. 2015;21(4):536-543.
doi:10.1111/odi.12318 .

Supić, Gordana, Kozomara, Ružica, Zeljić, Katarina, Stanimirović, Dragan, Magić, Marko, Surbatović, M., Jović, N., Magić, Zvonko, "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients" in Oral Diseases, 21, no. 4 (2015):536-543,
https://doi.org/10.1111/odi.12318 . .

TY  - JOUR
AU  - Mladenović, Irena
AU  - Dodić, Slobodan
AU  - Stošić, Srboljub
AU  - Petrović, Dragan
AU  - Čutović, Tatjana
AU  - Kozomara, Ružica
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1989
PB  - Churchill Livingstone, Edinburgh
T2  - Journal of Cranio-Maxillofacial Surgery
T1  - TMD in class III patients referred for orthognathic surgery: Psychological and dentition-related aspects (vol 42, pg 1604, 2014)
VL  - 43
IS  - 3
SP  - 301
EP  - 301
DO  - 10.1016/j.jcms.2014.12.010
ER  - 

@article{
author = "Mladenović, Irena and Dodić, Slobodan and Stošić, Srboljub and Petrović, Dragan and Čutović, Tatjana and Kozomara, Ružica",
year = "2015",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Journal of Cranio-Maxillofacial Surgery",
title = "TMD in class III patients referred for orthognathic surgery: Psychological and dentition-related aspects (vol 42, pg 1604, 2014)",
volume = "43",
number = "3",
pages = "301-301",
doi = "10.1016/j.jcms.2014.12.010"
}

Mladenović, I., Dodić, S., Stošić, S., Petrović, D., Čutović, T.,& Kozomara, R.. (2015). TMD in class III patients referred for orthognathic surgery: Psychological and dentition-related aspects (vol 42, pg 1604, 2014). in Journal of Cranio-Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 43(3), 301-301.
https://doi.org/10.1016/j.jcms.2014.12.010

Mladenović I, Dodić S, Stošić S, Petrović D, Čutović T, Kozomara R. TMD in class III patients referred for orthognathic surgery: Psychological and dentition-related aspects (vol 42, pg 1604, 2014). in Journal of Cranio-Maxillofacial Surgery. 2015;43(3):301-301.
doi:10.1016/j.jcms.2014.12.010 .

Mladenović, Irena, Dodić, Slobodan, Stošić, Srboljub, Petrović, Dragan, Čutović, Tatjana, Kozomara, Ružica, "TMD in class III patients referred for orthognathic surgery: Psychological and dentition-related aspects (vol 42, pg 1604, 2014)" in Journal of Cranio-Maxillofacial Surgery, 43, no. 3 (2015):301-301,
https://doi.org/10.1016/j.jcms.2014.12.010 . .

TY  - JOUR
AU  - Čutović, Tatjana
AU  - Jović, Nebojša
AU  - Stojanović, Ljiljana
AU  - Radojičić, Julija
AU  - Mladenović, Irena
AU  - Matijević, Stevo
AU  - Kozomara, Ružica
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1940
AB  - Bacground/Aim. The literature suggests different views on the correlation between the cranial base morphology and size and saggital intermaxillary relationships. The aim of this study was to investigate the cranial base morphology, including the frontal facial part in patients with mandibular prognathism, to clarify a certain ambiguities, in opposing viewspoints in the literature. Methods. Cephalometric radiographies of 60 patients were analyzed at the Dental Clinic of the Military Medical Academy, Belgrade, Serbia. All the patients were male, aged 18-35 years, with no previous orthodontic treatment. On the basis of dental and sceletal relations of jaws and teeth, the patients were divided into two groups: the group P (patients with mandibular prognathism) and the group E (the control group or eugnathic patients). A total of 15 cephalometric parametres related to the cranial base, frontal part of the face and sagittal intermaxillary relationships were measured and analyzed. Results. The results show that cranial base dimensions and the angle do not play a significant role in the development of mandibular prognathism. Interrelationship analysis indicated a statistically significant negative correlation between the cranial base angle (NSAr) and the angles of maxillary (SNA) and mandibular (SNB) prognathism, as well as a positive correlation between the angle of inclination of the ramus to the cranial base (GoArNS) and the angle of sagittal intermaxillary relationships (ANB). Sella turcica dimensions, its width and depth, as well as the nasal bone length were significantly increased in the patients with mandibular prognathism, while the other analyzed frontal part dimensions of the face were not changed by the malocclusion in comparison with the eugnathic patients. Conclusion. This study shows that the impact of the cranial base and the frontal part of the face on the development of profile in patients with mandibular prognathism is much smaller, but certainly more complex, so that morphogenetic tests of the maxillomandibular complex should be included in further assessment of this impact.
AB  - Uvod/Cilj. U literaturi postoje različiti stavovi o povezanosti morfologije i veličine kranijalne baze i sagitalnih međuviličnih odnosa. Cilj ovog rada bio je da se ispita morfologija kranijalne baze, uključujući i prednji deo lica, kod ispitanika sa mandibularnim prognatizmom da bi se razjasnile nedoumice donekle suprotnih stavova u literaturi. Metode. Analizirani su rendgenkefalometrijski snimci ukupno 60 bolesnika Klinike za stomatologiju VMA. Svi bolesnici bili su muškog pola, starosti od 18 do 35 godina koji ranije nisu bili ortodontski lečeni. Bolesnici su prema dentoskeletnim odnosima vilica i zuba bili svrstani u dve grupe: grupu P (bolesnici sa mandibularnim prognatizmom) i grupu E (kontrolna grupa ili grupa eugnatih bolesnika). Izmereno je i analizirano 15 kefalometrijskih parametara koji su se odnosili na kranijalnu bazu, frontalni deo lica kao i sagitalne međuvilične odnose. Rezultati. Dobijeni rezultati ukazuju da ni dimenzije kranijalne baze, ni njen ugao ne igraju značajnu ulogu u nastanku mandibularnog prognatizma. Analizom međuzavisnosti ustanovljeno je da postoji statistički značajna negativna korelacija između ugla kranijalne baze (NSAr) i uglova maksilarnog (SNA) i mandibularnog (SNB) prognatizma, kao i pozitivna korelacija između ugla nagiba ramusa prema kranijalnoj bazi (GoArNS) i ugla sagitalnih međuviličnih odnosa (ANB). Dimenzije sedlaste jamice (sella turcica), njena širina i dubina, kao i dužina nosne kosti statistički su značajno povećane kod bolesnika sa mandibularnim prognatizmom, dok ostale analizirane dimenzije prednjeg dela lica nisu bile izmenjene kod ove malokluzije u odnosu na eugnate bolesnike. Zaključak. Pokazalo se da je uticaj kranijalne baze i prednjeg dela lica na ispoljavanje profila kod bolesnika sa mandibularnim prognatizmom mnogo manji ali svakako složeniji, pa bi u dalja istraživanja trebalo uključiti morfogenetska ispitivanja maksilomandibularnog kompleksa kod ocenjivanja ovog uticaja.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - A cephalometric analysis of the cranial base and frontal part of the face in patients with mandibular prognathism
T1  - Kefalometrijska analiza kranijalne baze i prednjeg dela lica kod osoba sa mandibularnim prognatizmom
VL  - 71
IS  - 6
SP  - 534
EP  - 541
DO  - 10.2298/VSP121212011C
ER  - 

@article{
author = "Čutović, Tatjana and Jović, Nebojša and Stojanović, Ljiljana and Radojičić, Julija and Mladenović, Irena and Matijević, Stevo and Kozomara, Ružica",
year = "2014",
abstract = "Bacground/Aim. The literature suggests different views on the correlation between the cranial base morphology and size and saggital intermaxillary relationships. The aim of this study was to investigate the cranial base morphology, including the frontal facial part in patients with mandibular prognathism, to clarify a certain ambiguities, in opposing viewspoints in the literature. Methods. Cephalometric radiographies of 60 patients were analyzed at the Dental Clinic of the Military Medical Academy, Belgrade, Serbia. All the patients were male, aged 18-35 years, with no previous orthodontic treatment. On the basis of dental and sceletal relations of jaws and teeth, the patients were divided into two groups: the group P (patients with mandibular prognathism) and the group E (the control group or eugnathic patients). A total of 15 cephalometric parametres related to the cranial base, frontal part of the face and sagittal intermaxillary relationships were measured and analyzed. Results. The results show that cranial base dimensions and the angle do not play a significant role in the development of mandibular prognathism. Interrelationship analysis indicated a statistically significant negative correlation between the cranial base angle (NSAr) and the angles of maxillary (SNA) and mandibular (SNB) prognathism, as well as a positive correlation between the angle of inclination of the ramus to the cranial base (GoArNS) and the angle of sagittal intermaxillary relationships (ANB). Sella turcica dimensions, its width and depth, as well as the nasal bone length were significantly increased in the patients with mandibular prognathism, while the other analyzed frontal part dimensions of the face were not changed by the malocclusion in comparison with the eugnathic patients. Conclusion. This study shows that the impact of the cranial base and the frontal part of the face on the development of profile in patients with mandibular prognathism is much smaller, but certainly more complex, so that morphogenetic tests of the maxillomandibular complex should be included in further assessment of this impact., Uvod/Cilj. U literaturi postoje različiti stavovi o povezanosti morfologije i veličine kranijalne baze i sagitalnih međuviličnih odnosa. Cilj ovog rada bio je da se ispita morfologija kranijalne baze, uključujući i prednji deo lica, kod ispitanika sa mandibularnim prognatizmom da bi se razjasnile nedoumice donekle suprotnih stavova u literaturi. Metode. Analizirani su rendgenkefalometrijski snimci ukupno 60 bolesnika Klinike za stomatologiju VMA. Svi bolesnici bili su muškog pola, starosti od 18 do 35 godina koji ranije nisu bili ortodontski lečeni. Bolesnici su prema dentoskeletnim odnosima vilica i zuba bili svrstani u dve grupe: grupu P (bolesnici sa mandibularnim prognatizmom) i grupu E (kontrolna grupa ili grupa eugnatih bolesnika). Izmereno je i analizirano 15 kefalometrijskih parametara koji su se odnosili na kranijalnu bazu, frontalni deo lica kao i sagitalne međuvilične odnose. Rezultati. Dobijeni rezultati ukazuju da ni dimenzije kranijalne baze, ni njen ugao ne igraju značajnu ulogu u nastanku mandibularnog prognatizma. Analizom međuzavisnosti ustanovljeno je da postoji statistički značajna negativna korelacija između ugla kranijalne baze (NSAr) i uglova maksilarnog (SNA) i mandibularnog (SNB) prognatizma, kao i pozitivna korelacija između ugla nagiba ramusa prema kranijalnoj bazi (GoArNS) i ugla sagitalnih međuviličnih odnosa (ANB). Dimenzije sedlaste jamice (sella turcica), njena širina i dubina, kao i dužina nosne kosti statistički su značajno povećane kod bolesnika sa mandibularnim prognatizmom, dok ostale analizirane dimenzije prednjeg dela lica nisu bile izmenjene kod ove malokluzije u odnosu na eugnate bolesnike. Zaključak. Pokazalo se da je uticaj kranijalne baze i prednjeg dela lica na ispoljavanje profila kod bolesnika sa mandibularnim prognatizmom mnogo manji ali svakako složeniji, pa bi u dalja istraživanja trebalo uključiti morfogenetska ispitivanja maksilomandibularnog kompleksa kod ocenjivanja ovog uticaja.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "A cephalometric analysis of the cranial base and frontal part of the face in patients with mandibular prognathism, Kefalometrijska analiza kranijalne baze i prednjeg dela lica kod osoba sa mandibularnim prognatizmom",
volume = "71",
number = "6",
pages = "534-541",
doi = "10.2298/VSP121212011C"
}

Čutović, T., Jović, N., Stojanović, L., Radojičić, J., Mladenović, I., Matijević, S.,& Kozomara, R.. (2014). A cephalometric analysis of the cranial base and frontal part of the face in patients with mandibular prognathism. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(6), 534-541.
https://doi.org/10.2298/VSP121212011C

Čutović T, Jović N, Stojanović L, Radojičić J, Mladenović I, Matijević S, Kozomara R. A cephalometric analysis of the cranial base and frontal part of the face in patients with mandibular prognathism. in Vojnosanitetski pregled. 2014;71(6):534-541.
doi:10.2298/VSP121212011C .

Čutović, Tatjana, Jović, Nebojša, Stojanović, Ljiljana, Radojičić, Julija, Mladenović, Irena, Matijević, Stevo, Kozomara, Ružica, "A cephalometric analysis of the cranial base and frontal part of the face in patients with mandibular prognathism" in Vojnosanitetski pregled, 71, no. 6 (2014):534-541,
https://doi.org/10.2298/VSP121212011C . .

TY  - JOUR
AU  - Mladenović, Irena
AU  - Dodić, Slobodan
AU  - Stošić, Srboljub
AU  - Petrović, Dragan
AU  - Čutović, Tatjana
AU  - Kozomara, Ružica
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1891
AB  - Objective: To investigate temporomandibular disorders (TMD), psychosocial, and occlusal variables in class III orthognathic surgery patients with respect to the control subjects, and to compare psychosocial and occlusal features in class III patients with different Research Diagnostic Criteria for TMD (RDC/TMD) diagnoses. Materials and methods: The study enrolled 44 class III patients referred for orthognathic surgery and 44 individuals without a malocclusion. TMD, depression and somatization were assessed by RDC/TMD. Occlusal analysis included Helkimo's Occlusal Index items, overjet and overbite. Results: In the controls, patients with class III deformities had higher prevalence of myogenic TMD, increased grade of chronic pain, and more occlusal deviations. Within the study group, TMD patients reported higher depression score (P  lt  0.01), myofascial pain was related to higher depression and somatization grades (P  lt  0.01, P  lt  0.05 respectively), and disc displacement showed relation with RCP-ICP slide interferences (P  lt  0.05). Conclusion: With respect to subjects without a malocclusion, TMD in class III dentofacial deformities is similar in prevalence, but differs in clinical appearance. Occlusal, but not psychosocial features deviate from those in the controls. While psychosocial variables accompanied TMD and myofascial pain, increased RCP-ICP slide was related to disc displacement in class III patients.
PB  - Churchill Livingstone, Edinburgh
T2  - Journal of Cranio-Maxillofacial Surgery
T1  - TMD in class III patients referred for orthognathic surgery: Psychological and dentition-related aspects
VL  - 42
IS  - 8
SP  - 1604
EP  - 1609
DO  - 10.1016/j.jcms.2014.04.029
ER  - 

@article{
author = "Mladenović, Irena and Dodić, Slobodan and Stošić, Srboljub and Petrović, Dragan and Čutović, Tatjana and Kozomara, Ružica",
year = "2014",
abstract = "Objective: To investigate temporomandibular disorders (TMD), psychosocial, and occlusal variables in class III orthognathic surgery patients with respect to the control subjects, and to compare psychosocial and occlusal features in class III patients with different Research Diagnostic Criteria for TMD (RDC/TMD) diagnoses. Materials and methods: The study enrolled 44 class III patients referred for orthognathic surgery and 44 individuals without a malocclusion. TMD, depression and somatization were assessed by RDC/TMD. Occlusal analysis included Helkimo's Occlusal Index items, overjet and overbite. Results: In the controls, patients with class III deformities had higher prevalence of myogenic TMD, increased grade of chronic pain, and more occlusal deviations. Within the study group, TMD patients reported higher depression score (P  lt  0.01), myofascial pain was related to higher depression and somatization grades (P  lt  0.01, P  lt  0.05 respectively), and disc displacement showed relation with RCP-ICP slide interferences (P  lt  0.05). Conclusion: With respect to subjects without a malocclusion, TMD in class III dentofacial deformities is similar in prevalence, but differs in clinical appearance. Occlusal, but not psychosocial features deviate from those in the controls. While psychosocial variables accompanied TMD and myofascial pain, increased RCP-ICP slide was related to disc displacement in class III patients.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Journal of Cranio-Maxillofacial Surgery",
title = "TMD in class III patients referred for orthognathic surgery: Psychological and dentition-related aspects",
volume = "42",
number = "8",
pages = "1604-1609",
doi = "10.1016/j.jcms.2014.04.029"
}

Mladenović, I., Dodić, S., Stošić, S., Petrović, D., Čutović, T.,& Kozomara, R.. (2014). TMD in class III patients referred for orthognathic surgery: Psychological and dentition-related aspects. in Journal of Cranio-Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 42(8), 1604-1609.
https://doi.org/10.1016/j.jcms.2014.04.029

Mladenović I, Dodić S, Stošić S, Petrović D, Čutović T, Kozomara R. TMD in class III patients referred for orthognathic surgery: Psychological and dentition-related aspects. in Journal of Cranio-Maxillofacial Surgery. 2014;42(8):1604-1609.
doi:10.1016/j.jcms.2014.04.029 .

Mladenović, Irena, Dodić, Slobodan, Stošić, Srboljub, Petrović, Dragan, Čutović, Tatjana, Kozomara, Ružica, "TMD in class III patients referred for orthognathic surgery: Psychological and dentition-related aspects" in Journal of Cranio-Maxillofacial Surgery, 42, no. 8 (2014):1604-1609,
https://doi.org/10.1016/j.jcms.2014.04.029 . .

TY  - JOUR
AU  - Petković, A. B.
AU  - Matić, S. M.
AU  - Stamatović, Novak
AU  - Vojvodić, Danilo
AU  - Todorović, T. M.
AU  - Lazić, Z. R.
AU  - Kozomara, Ružica
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1594
AB  - Analysis of pen-implant crevicular fluid (PICF) offers a non-invasive means of studying the host response in pen-implant disease and may provide an early indication of patients at risk for active disease. This study examined the PICF levels of interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in patients with non-manifesting inflammation, early and late stages of mucositis. The study group comprised 90 adult healthy volunteers with endosseal titanium implants inserted. Samples were taken from pen-implant sulcus using a filter paper technique. Implant tissues were categorized clinically as healthy, early mucositis or advanced mucositis. Clinical manifestations were determined by: gingival index and bleeding on probing, plaque index and radiographic analyses. Cytokine concentrations were assesed using commercially available enzyme-linked immunosorbent assay kits. Patients from the control group (healthy patients) have significantly lower concentrations of IL-1 beta, TNF-alpha, IL-8 and MIP-1 alpha in PICF compared with both groups with mucositis. Positive correlation was noted in the control group between IL-1 beta and TNF-alpha and between MIP-1 alpha and IL-8 in the group with early mucositis. The results suggest that cytokines could be prognostic markers of implant failure.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition
VL  - 39
IS  - 5
SP  - 478
EP  - 485
DO  - 10.1016/j.ijom.2010.01.014
ER  - 

@article{
author = "Petković, A. B. and Matić, S. M. and Stamatović, Novak and Vojvodić, Danilo and Todorović, T. M. and Lazić, Z. R. and Kozomara, Ružica",
year = "2010",
abstract = "Analysis of pen-implant crevicular fluid (PICF) offers a non-invasive means of studying the host response in pen-implant disease and may provide an early indication of patients at risk for active disease. This study examined the PICF levels of interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in patients with non-manifesting inflammation, early and late stages of mucositis. The study group comprised 90 adult healthy volunteers with endosseal titanium implants inserted. Samples were taken from pen-implant sulcus using a filter paper technique. Implant tissues were categorized clinically as healthy, early mucositis or advanced mucositis. Clinical manifestations were determined by: gingival index and bleeding on probing, plaque index and radiographic analyses. Cytokine concentrations were assesed using commercially available enzyme-linked immunosorbent assay kits. Patients from the control group (healthy patients) have significantly lower concentrations of IL-1 beta, TNF-alpha, IL-8 and MIP-1 alpha in PICF compared with both groups with mucositis. Positive correlation was noted in the control group between IL-1 beta and TNF-alpha and between MIP-1 alpha and IL-8 in the group with early mucositis. The results suggest that cytokines could be prognostic markers of implant failure.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition",
volume = "39",
number = "5",
pages = "478-485",
doi = "10.1016/j.ijom.2010.01.014"
}

Petković, A. B., Matić, S. M., Stamatović, N., Vojvodić, D., Todorović, T. M., Lazić, Z. R.,& Kozomara, R.. (2010). Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 39(5), 478-485.
https://doi.org/10.1016/j.ijom.2010.01.014

Petković AB, Matić SM, Stamatović N, Vojvodić D, Todorović TM, Lazić ZR, Kozomara R. Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition. in International Journal of Oral & Maxillofacial Surgery. 2010;39(5):478-485.
doi:10.1016/j.ijom.2010.01.014 .

Petković, A. B., Matić, S. M., Stamatović, Novak, Vojvodić, Danilo, Todorović, T. M., Lazić, Z. R., Kozomara, Ružica, "Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition" in International Journal of Oral & Maxillofacial Surgery, 39, no. 5 (2010):478-485,
https://doi.org/10.1016/j.ijom.2010.01.014 . .

TY  - THES
AU  - Kozomara, Ružica
PY  - 1994
UR  - https://plus.sr.cobiss.net/opac7/bib/1024054670
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/298
T1  - Uticaj adrenalina u lokalnom anestetiku lidokainu na nivo glukoze u krvi dijabetičara
UR  - https://hdl.handle.net/21.15107/rcub_smile_298
ER  - 

@mastersthesis{
author = "Kozomara, Ružica",
year = "1994",
title = "Uticaj adrenalina u lokalnom anestetiku lidokainu na nivo glukoze u krvi dijabetičara",
url = "https://hdl.handle.net/21.15107/rcub_smile_298"
}

Kozomara, R.. (1994). Uticaj adrenalina u lokalnom anestetiku lidokainu na nivo glukoze u krvi dijabetičara. .
https://hdl.handle.net/21.15107/rcub_smile_298

Kozomara R. Uticaj adrenalina u lokalnom anestetiku lidokainu na nivo glukoze u krvi dijabetičara. 1994;.
https://hdl.handle.net/21.15107/rcub_smile_298 .

Kozomara, Ružica, "Uticaj adrenalina u lokalnom anestetiku lidokainu na nivo glukoze u krvi dijabetičara" (1994),
https://hdl.handle.net/21.15107/rcub_smile_298 .