TY  - JOUR
AU  - Magić, Marko
AU  - Zeljić, Katarina
AU  - Jovandić, Stevo
AU  - Stepić, Jelena
AU  - Pejović, Marko
AU  - Čolić, Snježana
AU  - Magić, Zvonko
AU  - Supić, Gordana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2382
AB  - ObjectivesGenetic variants in the hedgehog signaling pathway and VDR gene are involved in inflammatory responses and neoplastic transformation. Current study investigated whether single-nucleotide polymorphisms in the hedgehog pathway genes PTCH1, GLI1, SMO, and VDR contribute to susceptibility to odontogenic cystic lesions, odontogenic keratocysts, or inflammatory radicular cysts.Material and methodsCurrent study examined polymorphisms of PTCH1 (rs357564) and PTCH1 insertion (IVS1-83), GLI1 (rs2228224, rs2228226), SMO (rs2228617), and VDR (rs2228570, rs731236, rs7975232). A case-control study was conducted on 41 keratocyst cases, 43 radicular cyst cases, and control group of 93 healthy individuals without cystic lesions, radiographically confirmed. Single-nucleotide polymorphisms were assessed by real-time and TaqMan SNP genotyping assays, while PTCH1 insertion 18bp IVS1-83 polymorphism was determined by PCR.ResultsThe difference in genotype distribution between keratocyst cases and control group was observed for PTCH1 IVS1-83 and GLI1 rs2228224 polymorphism (p=0.022, p=0.030, respectively). Homozygous mutant GG genotype within GLI1 rs2228224 is associated with increased susceptibility for odontogenous keratocysts, with adjusted odds ratio of 4.098 (confidence interval of 1.482-11.328, p=0.007).ConclusionGLI1 rs2228224 and PTCH1 polymorphisms could predispose to odontogenic keratocysts.Clinical relevanceVariants in hedgehog signaling pathway genes, such as GLI1 and PTCH1, and vitamin D receptor gene, might be considered as molecular risk factors in odontogenic cystic lesions and potential targets for novel therapeutic approaches.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Hedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesions
VL  - 23
IS  - 6
SP  - 2675
EP  - 2684
DO  - 10.1007/s00784-018-2686-5
ER  - 

@article{
author = "Magić, Marko and Zeljić, Katarina and Jovandić, Stevo and Stepić, Jelena and Pejović, Marko and Čolić, Snježana and Magić, Zvonko and Supić, Gordana",
year = "2019",
abstract = "ObjectivesGenetic variants in the hedgehog signaling pathway and VDR gene are involved in inflammatory responses and neoplastic transformation. Current study investigated whether single-nucleotide polymorphisms in the hedgehog pathway genes PTCH1, GLI1, SMO, and VDR contribute to susceptibility to odontogenic cystic lesions, odontogenic keratocysts, or inflammatory radicular cysts.Material and methodsCurrent study examined polymorphisms of PTCH1 (rs357564) and PTCH1 insertion (IVS1-83), GLI1 (rs2228224, rs2228226), SMO (rs2228617), and VDR (rs2228570, rs731236, rs7975232). A case-control study was conducted on 41 keratocyst cases, 43 radicular cyst cases, and control group of 93 healthy individuals without cystic lesions, radiographically confirmed. Single-nucleotide polymorphisms were assessed by real-time and TaqMan SNP genotyping assays, while PTCH1 insertion 18bp IVS1-83 polymorphism was determined by PCR.ResultsThe difference in genotype distribution between keratocyst cases and control group was observed for PTCH1 IVS1-83 and GLI1 rs2228224 polymorphism (p=0.022, p=0.030, respectively). Homozygous mutant GG genotype within GLI1 rs2228224 is associated with increased susceptibility for odontogenous keratocysts, with adjusted odds ratio of 4.098 (confidence interval of 1.482-11.328, p=0.007).ConclusionGLI1 rs2228224 and PTCH1 polymorphisms could predispose to odontogenic keratocysts.Clinical relevanceVariants in hedgehog signaling pathway genes, such as GLI1 and PTCH1, and vitamin D receptor gene, might be considered as molecular risk factors in odontogenic cystic lesions and potential targets for novel therapeutic approaches.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Hedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesions",
volume = "23",
number = "6",
pages = "2675-2684",
doi = "10.1007/s00784-018-2686-5"
}

Magić, M., Zeljić, K., Jovandić, S., Stepić, J., Pejović, M., Čolić, S., Magić, Z.,& Supić, G.. (2019). Hedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesions. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 23(6), 2675-2684.
https://doi.org/10.1007/s00784-018-2686-5

Magić M, Zeljić K, Jovandić S, Stepić J, Pejović M, Čolić S, Magić Z, Supić G. Hedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesions. in Clinical Oral Investigations. 2019;23(6):2675-2684.
doi:10.1007/s00784-018-2686-5 .

Magić, Marko, Zeljić, Katarina, Jovandić, Stevo, Stepić, Jelena, Pejović, Marko, Čolić, Snježana, Magić, Zvonko, Supić, Gordana, "Hedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesions" in Clinical Oral Investigations, 23, no. 6 (2019):2675-2684,
https://doi.org/10.1007/s00784-018-2686-5 . .

TY  - JOUR
AU  - Kujundzić, Bojan
AU  - Zeljić, Katarina
AU  - Supić, Gordana
AU  - Magić, Marko
AU  - Stanimirović, Dragan
AU  - Ilić, Vesna
AU  - Jovanović, Barbara
AU  - Magić, Zvonko
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2136
AB  - The current study investigated the association between VDR EcoRV (rs4516035), FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236), CYP27B1 (rs4646536), CYP24A1 (rs2296241), and MTHFR (rs1801133) gene polymorphisms and risk of oral lichen planus (OLP) occurrence. The study group consisted of 65 oral lichen planus patients and 100 healthy blood donors in the control group. Single nucleotide polymorphisms were genotyped by real time PCR or PCR-restriction fragment length polymorphism (RFLP) method. Heterozygous as well as mutated genotype of vitamin D receptor (VDR) FokI (rs2228570) polymorphism was associated with increased oral lichen planus risk in comparison with wild type genotype (odds ratio (OR) = 3.877, p = 0.017, OR = 38.153, p = 0.001, respectively). A significantly decreased OLP risk was observed for heterozygous genotype of rs2296241 polymorphism in CYP24A1 gene compared with the wild type form (OR = 0.314, p = 0.012). VDR gene polymorphisms ApaI and TaqI were in linkage disequilibrium (D' = 0.71, r (2) = 0.22). Identified haplotype AT was associated with decreased OLP risk (OR = 0.592, p = 0.047). Our results highlight the possible important role of VDR FokI (rs2228570) and CYP24A1 rs2296241 gene polymorphisms for oral lichen planus susceptibility. Identification of new molecular biomarkers could potentially contribute to determination of individuals with OLP predisposition.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk
VL  - 20
IS  - 4
SP  - 781
EP  - 789
DO  - 10.1007/s00784-015-1572-7
ER  - 

@article{
author = "Kujundzić, Bojan and Zeljić, Katarina and Supić, Gordana and Magić, Marko and Stanimirović, Dragan and Ilić, Vesna and Jovanović, Barbara and Magić, Zvonko",
year = "2016",
abstract = "The current study investigated the association between VDR EcoRV (rs4516035), FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236), CYP27B1 (rs4646536), CYP24A1 (rs2296241), and MTHFR (rs1801133) gene polymorphisms and risk of oral lichen planus (OLP) occurrence. The study group consisted of 65 oral lichen planus patients and 100 healthy blood donors in the control group. Single nucleotide polymorphisms were genotyped by real time PCR or PCR-restriction fragment length polymorphism (RFLP) method. Heterozygous as well as mutated genotype of vitamin D receptor (VDR) FokI (rs2228570) polymorphism was associated with increased oral lichen planus risk in comparison with wild type genotype (odds ratio (OR) = 3.877, p = 0.017, OR = 38.153, p = 0.001, respectively). A significantly decreased OLP risk was observed for heterozygous genotype of rs2296241 polymorphism in CYP24A1 gene compared with the wild type form (OR = 0.314, p = 0.012). VDR gene polymorphisms ApaI and TaqI were in linkage disequilibrium (D' = 0.71, r (2) = 0.22). Identified haplotype AT was associated with decreased OLP risk (OR = 0.592, p = 0.047). Our results highlight the possible important role of VDR FokI (rs2228570) and CYP24A1 rs2296241 gene polymorphisms for oral lichen planus susceptibility. Identification of new molecular biomarkers could potentially contribute to determination of individuals with OLP predisposition.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk",
volume = "20",
number = "4",
pages = "781-789",
doi = "10.1007/s00784-015-1572-7"
}

Kujundzić, B., Zeljić, K., Supić, G., Magić, M., Stanimirović, D., Ilić, V., Jovanović, B.,& Magić, Z.. (2016). Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 20(4), 781-789.
https://doi.org/10.1007/s00784-015-1572-7

Kujundzić B, Zeljić K, Supić G, Magić M, Stanimirović D, Ilić V, Jovanović B, Magić Z. Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk. in Clinical Oral Investigations. 2016;20(4):781-789.
doi:10.1007/s00784-015-1572-7 .

Kujundzić, Bojan, Zeljić, Katarina, Supić, Gordana, Magić, Marko, Stanimirović, Dragan, Ilić, Vesna, Jovanović, Barbara, Magić, Zvonko, "Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk" in Clinical Oral Investigations, 20, no. 4 (2016):781-789,
https://doi.org/10.1007/s00784-015-1572-7 . .

TY  - JOUR
AU  - Supić, Gordana
AU  - Kozomara, Ružica
AU  - Zeljić, Katarina
AU  - Stanimirović, Dragan
AU  - Magić, Marko
AU  - Surbatović, M.
AU  - Jović, N.
AU  - Magić, Zvonko
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1976
AB  - ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients
VL  - 21
IS  - 4
SP  - 536
EP  - 543
DO  - 10.1111/odi.12318
ER  - 

@article{
author = "Supić, Gordana and Kozomara, Ružica and Zeljić, Katarina and Stanimirović, Dragan and Magić, Marko and Surbatović, M. and Jović, N. and Magić, Zvonko",
year = "2015",
abstract = "ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients",
volume = "21",
number = "4",
pages = "536-543",
doi = "10.1111/odi.12318"
}

Supić, G., Kozomara, R., Zeljić, K., Stanimirović, D., Magić, M., Surbatović, M., Jović, N.,& Magić, Z.. (2015). HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases
Wiley, Hoboken., 21(4), 536-543.
https://doi.org/10.1111/odi.12318

Supić G, Kozomara R, Zeljić K, Stanimirović D, Magić M, Surbatović M, Jović N, Magić Z. HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases. 2015;21(4):536-543.
doi:10.1111/odi.12318 .

Supić, Gordana, Kozomara, Ružica, Zeljić, Katarina, Stanimirović, Dragan, Magić, Marko, Surbatović, M., Jović, N., Magić, Zvonko, "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients" in Oral Diseases, 21, no. 4 (2015):536-543,
https://doi.org/10.1111/odi.12318 . .

TY  - JOUR
AU  - Stanimirović, Dragan
AU  - Zeljić, Katarina
AU  - Janković, Ljiljana
AU  - Magić, Marko
AU  - Hadži-Mihailović, Miloš
AU  - Magić, Zvonko
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1818
AB  - The aim of this study was to assess whether polymorphisms in toll-like receptor (TLR) and cluster of differentiation 14 (CD14) genes are associated with oral lichen planus (OLP) risk and clinical course of the disease. The study group consisted of 101 patients with confirmed OLP and 104 healthy blood donors without systemic or oral mucosal diseases. Single nucleotide polymorphisms of TLR2 (rs3804099), TLR3 (rs3775291 and rs5743312), TLR4 (rs4986790 and rs4986791), and CD14 (rs2569190) genes were genotyped using real-time PCR or PCR-restriction fragment length polymorphism (PCR-RFLP). The rs5743312 TLR3 gene polymorphism was associated with increased OLP risk in comparison with the wild type genotype (OR = 15.984, P = 0.011). No association with OLP risk was observed for the polymorphisms studied in TLR2, TLR4 and CD14 genes or for the rs3775291 polymorphism of the TLR3 gene. The polymorphisms of the TLR3 gene were in linkage disequilibrium (D ' = 1, r(2) = 0.1). Identified haplotypes were not associated with the risk of OLP. The findings of the current study suggest that the TT genotype of the rs5743312 TLR3 gene polymorphism may play a significant role in the aetiology of OLP.
PB  - Wiley-Blackwell, Hoboken
T2  - European Journal of Oral Sciences
T1  - TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk
VL  - 121
IS  - 5
SP  - 421
EP  - 426
DO  - 10.1111/eos.12074
ER  - 

@article{
author = "Stanimirović, Dragan and Zeljić, Katarina and Janković, Ljiljana and Magić, Marko and Hadži-Mihailović, Miloš and Magić, Zvonko",
year = "2013",
abstract = "The aim of this study was to assess whether polymorphisms in toll-like receptor (TLR) and cluster of differentiation 14 (CD14) genes are associated with oral lichen planus (OLP) risk and clinical course of the disease. The study group consisted of 101 patients with confirmed OLP and 104 healthy blood donors without systemic or oral mucosal diseases. Single nucleotide polymorphisms of TLR2 (rs3804099), TLR3 (rs3775291 and rs5743312), TLR4 (rs4986790 and rs4986791), and CD14 (rs2569190) genes were genotyped using real-time PCR or PCR-restriction fragment length polymorphism (PCR-RFLP). The rs5743312 TLR3 gene polymorphism was associated with increased OLP risk in comparison with the wild type genotype (OR = 15.984, P = 0.011). No association with OLP risk was observed for the polymorphisms studied in TLR2, TLR4 and CD14 genes or for the rs3775291 polymorphism of the TLR3 gene. The polymorphisms of the TLR3 gene were in linkage disequilibrium (D ' = 1, r(2) = 0.1). Identified haplotypes were not associated with the risk of OLP. The findings of the current study suggest that the TT genotype of the rs5743312 TLR3 gene polymorphism may play a significant role in the aetiology of OLP.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "European Journal of Oral Sciences",
title = "TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk",
volume = "121",
number = "5",
pages = "421-426",
doi = "10.1111/eos.12074"
}

Stanimirović, D., Zeljić, K., Janković, L., Magić, M., Hadži-Mihailović, M.,& Magić, Z.. (2013). TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk. in European Journal of Oral Sciences
Wiley-Blackwell, Hoboken., 121(5), 421-426.
https://doi.org/10.1111/eos.12074

Stanimirović D, Zeljić K, Janković L, Magić M, Hadži-Mihailović M, Magić Z. TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk. in European Journal of Oral Sciences. 2013;121(5):421-426.
doi:10.1111/eos.12074 .

Stanimirović, Dragan, Zeljić, Katarina, Janković, Ljiljana, Magić, Marko, Hadži-Mihailović, Miloš, Magić, Zvonko, "TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk" in European Journal of Oral Sciences, 121, no. 5 (2013):421-426,
https://doi.org/10.1111/eos.12074 . .