Vukadinović, Miroslav

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  • Vukadinović, Miroslav (26)

Author's Bibliography

Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential

Milošević-Marković, Maja; Lazarević, Miloš; Toljić, Boško; Petrović, Milan; Vukadinović, Miroslav; Jezdić, Zoran; Aničić, Boban; Jelovac, Drago; Jovanović, Svetlana; Milašin, Jelena

(TECH SCIENCE PRESS, 2021)

TY  - JOUR
AU  - Milošević-Marković, Maja
AU  - Lazarević, Miloš
AU  - Toljić, Boško
AU  - Petrović, Milan
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Aničić, Boban
AU  - Jelovac, Drago
AU  - Jovanović, Svetlana
AU  - Milašin, Jelena
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3283
AB  - Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.
PB  - TECH SCIENCE PRESS
T2  - BIOCELL
T1  - Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential
VL  - 45
IS  - 6
SP  - 1543
EP  - 1550
DO  - 10.32604/biocell.2021.015060
ER  - 
@article{
author = "Milošević-Marković, Maja and Lazarević, Miloš and Toljić, Boško and Petrović, Milan and Vukadinović, Miroslav and Jezdić, Zoran and Aničić, Boban and Jelovac, Drago and Jovanović, Svetlana and Milašin, Jelena",
year = "2021",
abstract = "Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.",
publisher = "TECH SCIENCE PRESS",
journal = "BIOCELL",
title = "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential",
volume = "45",
number = "6",
pages = "1543-1550",
doi = "10.32604/biocell.2021.015060"
}
Milošević-Marković, M., Lazarević, M., Toljić, B., Petrović, M., Vukadinović, M., Jezdić, Z., Aničić, B., Jelovac, D., Jovanović, S.,& Milašin, J.. (2021). Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential. in BIOCELL
TECH SCIENCE PRESS., 45(6), 1543-1550.
https://doi.org/10.32604/biocell.2021.015060
Milošević-Marković M, Lazarević M, Toljić B, Petrović M, Vukadinović M, Jezdić Z, Aničić B, Jelovac D, Jovanović S, Milašin J. Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential. in BIOCELL. 2021;45(6):1543-1550.
doi:10.32604/biocell.2021.015060 .
Milošević-Marković, Maja, Lazarević, Miloš, Toljić, Boško, Petrović, Milan, Vukadinović, Miroslav, Jezdić, Zoran, Aničić, Boban, Jelovac, Drago, Jovanović, Svetlana, Milašin, Jelena, "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential" in BIOCELL, 45, no. 6 (2021):1543-1550,
https://doi.org/10.32604/biocell.2021.015060 . .
1
1

Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma

Lazarević, Miloš; Milošević, Maja; Trišić, Dijana; Toljić, Boško; Simonović, Jelena; Nikolić, Nadja; Miković, Nikola; Jelovac, Drago; Petrović, Milan; Vukadinović, Miroslav; Milašin, Jelena

(Balkan Union of Oncology (B.U.ON.), 2018)

TY  - JOUR
AU  - Lazarević, Miloš
AU  - Milošević, Maja
AU  - Trišić, Dijana
AU  - Toljić, Boško
AU  - Simonović, Jelena
AU  - Nikolić, Nadja
AU  - Miković, Nikola
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2271
AB  - Purpose: Recent evidence suggests that small subpopulations of stem-like cells are accountable for tumour initiation, progression and metastasis. Until now, studies were focused exclusively on the characterization of these cell populations within the tumour itself, while tumour margins were neglected, although it is known that the histological and molecular status of tumour margins may play a significant role in the course of the disease. Therefore, the aims of the study were to isolate cells from oral squamous cell carcinomas and their respective margins, to characterize these cells using specific markers, to assess their self-renewal potential and determine their chemoresistance. Methods: Cell cultures were obtained from 12 tissue specimens (6 tumours and 6 margins). Total RNA was extracted and gene expression analysis was done by real-time PCR (RTPCR). Flow cytometry, immunocytometry, sphere formation and MTT assays were also applied. Results: With minor differences, cells originating from both tumours and tumour margins showed the presence of stem cell markers CD133, Nanog, Sox2, CD44, and Oct4, had the capacity to form spheroids and showed chemoresistance. Conclusions: Subpopulations of margin cells appeared to have sternness properties which might raise the question of re-evaluation of optimal surgical management.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma
VL  - 23
IS  - 6
SP  - 1686
EP  - 1692
UR  - https://hdl.handle.net/21.15107/rcub_smile_2271
ER  - 
@article{
author = "Lazarević, Miloš and Milošević, Maja and Trišić, Dijana and Toljić, Boško and Simonović, Jelena and Nikolić, Nadja and Miković, Nikola and Jelovac, Drago and Petrović, Milan and Vukadinović, Miroslav and Milašin, Jelena",
year = "2018",
abstract = "Purpose: Recent evidence suggests that small subpopulations of stem-like cells are accountable for tumour initiation, progression and metastasis. Until now, studies were focused exclusively on the characterization of these cell populations within the tumour itself, while tumour margins were neglected, although it is known that the histological and molecular status of tumour margins may play a significant role in the course of the disease. Therefore, the aims of the study were to isolate cells from oral squamous cell carcinomas and their respective margins, to characterize these cells using specific markers, to assess their self-renewal potential and determine their chemoresistance. Methods: Cell cultures were obtained from 12 tissue specimens (6 tumours and 6 margins). Total RNA was extracted and gene expression analysis was done by real-time PCR (RTPCR). Flow cytometry, immunocytometry, sphere formation and MTT assays were also applied. Results: With minor differences, cells originating from both tumours and tumour margins showed the presence of stem cell markers CD133, Nanog, Sox2, CD44, and Oct4, had the capacity to form spheroids and showed chemoresistance. Conclusions: Subpopulations of margin cells appeared to have sternness properties which might raise the question of re-evaluation of optimal surgical management.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma",
volume = "23",
number = "6",
pages = "1686-1692",
url = "https://hdl.handle.net/21.15107/rcub_smile_2271"
}
Lazarević, M., Milošević, M., Trišić, D., Toljić, B., Simonović, J., Nikolić, N., Miković, N., Jelovac, D., Petrović, M., Vukadinović, M.,& Milašin, J.. (2018). Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 23(6), 1686-1692.
https://hdl.handle.net/21.15107/rcub_smile_2271
Lazarević M, Milošević M, Trišić D, Toljić B, Simonović J, Nikolić N, Miković N, Jelovac D, Petrović M, Vukadinović M, Milašin J. Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma. in Journal of BUON. 2018;23(6):1686-1692.
https://hdl.handle.net/21.15107/rcub_smile_2271 .
Lazarević, Miloš, Milošević, Maja, Trišić, Dijana, Toljić, Boško, Simonović, Jelena, Nikolić, Nadja, Miković, Nikola, Jelovac, Drago, Petrović, Milan, Vukadinović, Miroslav, Milašin, Jelena, "Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma" in Journal of BUON, 23, no. 6 (2018):1686-1692,
https://hdl.handle.net/21.15107/rcub_smile_2271 .
10

Synthesis of PMMA/ZNO nanoparticles composite used for resin teeth

Popović, Danica; Bobovnik, Rajko; Bolka, Silvester; Vukadinović, Miroslav; Lazić, Vojkan; Rudolf, Rebeka

(Inst Za Kovinske Materiale I In Tehnologie, Ljubjana, 2017)

TY  - JOUR
AU  - Popović, Danica
AU  - Bobovnik, Rajko
AU  - Bolka, Silvester
AU  - Vukadinović, Miroslav
AU  - Lazić, Vojkan
AU  - Rudolf, Rebeka
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2210
AB  - Wear resistance is one of the most important physical properties of the artificial teeth used in acrylic dentures. The goal of this research was to synthesize a new composite material made of matrix Poly-(methyl methacrylate)-PMMA with different percentages (2 % and 3 % of volume fractions) of zinc-oxide nanoparticles (ZnO NPs) as reinforcing elements, to improve its mechanical properties. The dynamic mechanical behaviour of this composite was studied through the DMA method in comparison to the pure PMMA supported by the characterization of their microstructures. Then the wear resistance was analysed on the samples, which were prepared in the form of teeth. In this context their vertical height loss was measured after 100,000 chewing cycles on a chewing simulator, before and after the artificial thermal ageing. Investigations showed that the PMMA/ZnO NP composites dampened the vibrations better than the pure PMMA, which could be assigned to the homogenous distribution of ZnO NPs in the PMMA matrix. It was found that the mean vertical height loss for the pure PMMA teeth was significantly higher (more than 4 times) compared to composite teeth made with ZnO NPs. Introducing the thermal artificial ageing led to the finding that there was no effect on the height loss by the composite material with 3 % of volume fractions of ZnO NPs. Based on this it was concluded that PMMA/ZnO NPs composites showed improved in-vitro wear resistance compared to acrylic-resin denture teeth, so this new composite material should be preferred when occlusal stability is considered to be of high priority.
PB  - Inst Za Kovinske Materiale I In Tehnologie, Ljubjana
T2  - Materiali in Tehnologije
T1  - Synthesis of PMMA/ZNO nanoparticles composite used for resin teeth
VL  - 51
IS  - 5
SP  - 871
EP  - 878
DO  - 10.17222/mit.2017.025
ER  - 
@article{
author = "Popović, Danica and Bobovnik, Rajko and Bolka, Silvester and Vukadinović, Miroslav and Lazić, Vojkan and Rudolf, Rebeka",
year = "2017",
abstract = "Wear resistance is one of the most important physical properties of the artificial teeth used in acrylic dentures. The goal of this research was to synthesize a new composite material made of matrix Poly-(methyl methacrylate)-PMMA with different percentages (2 % and 3 % of volume fractions) of zinc-oxide nanoparticles (ZnO NPs) as reinforcing elements, to improve its mechanical properties. The dynamic mechanical behaviour of this composite was studied through the DMA method in comparison to the pure PMMA supported by the characterization of their microstructures. Then the wear resistance was analysed on the samples, which were prepared in the form of teeth. In this context their vertical height loss was measured after 100,000 chewing cycles on a chewing simulator, before and after the artificial thermal ageing. Investigations showed that the PMMA/ZnO NP composites dampened the vibrations better than the pure PMMA, which could be assigned to the homogenous distribution of ZnO NPs in the PMMA matrix. It was found that the mean vertical height loss for the pure PMMA teeth was significantly higher (more than 4 times) compared to composite teeth made with ZnO NPs. Introducing the thermal artificial ageing led to the finding that there was no effect on the height loss by the composite material with 3 % of volume fractions of ZnO NPs. Based on this it was concluded that PMMA/ZnO NPs composites showed improved in-vitro wear resistance compared to acrylic-resin denture teeth, so this new composite material should be preferred when occlusal stability is considered to be of high priority.",
publisher = "Inst Za Kovinske Materiale I In Tehnologie, Ljubjana",
journal = "Materiali in Tehnologije",
title = "Synthesis of PMMA/ZNO nanoparticles composite used for resin teeth",
volume = "51",
number = "5",
pages = "871-878",
doi = "10.17222/mit.2017.025"
}
Popović, D., Bobovnik, R., Bolka, S., Vukadinović, M., Lazić, V.,& Rudolf, R.. (2017). Synthesis of PMMA/ZNO nanoparticles composite used for resin teeth. in Materiali in Tehnologije
Inst Za Kovinske Materiale I In Tehnologie, Ljubjana., 51(5), 871-878.
https://doi.org/10.17222/mit.2017.025
Popović D, Bobovnik R, Bolka S, Vukadinović M, Lazić V, Rudolf R. Synthesis of PMMA/ZNO nanoparticles composite used for resin teeth. in Materiali in Tehnologije. 2017;51(5):871-878.
doi:10.17222/mit.2017.025 .
Popović, Danica, Bobovnik, Rajko, Bolka, Silvester, Vukadinović, Miroslav, Lazić, Vojkan, Rudolf, Rebeka, "Synthesis of PMMA/ZNO nanoparticles composite used for resin teeth" in Materiali in Tehnologije, 51, no. 5 (2017):871-878,
https://doi.org/10.17222/mit.2017.025 . .
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9

The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma

Jelovac, Drago; Tepavčević, Zvezdana; Nikolić, Nadja; Ilić, Branislav; Eljabo, Najib; Popović, Branka; Čarkić, Jelena; Konstantinović, Vitomir; Vukadinović, Miroslav; Miličić, Biljana; Milašin, Jelena

(Churchill Livingstone, Edinburgh, 2016)

TY  - JOUR
AU  - Jelovac, Drago
AU  - Tepavčević, Zvezdana
AU  - Nikolić, Nadja
AU  - Ilić, Branislav
AU  - Eljabo, Najib
AU  - Popović, Branka
AU  - Čarkić, Jelena
AU  - Konstantinović, Vitomir
AU  - Vukadinović, Miroslav
AU  - Miličić, Biljana
AU  - Milašin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2180
AB  - The tumour subtype, TNM classification, and histopathological data are sometimes not sufficient for understanding and assessing the behaviour of oral cancers. In an attempt to find additional markers of tumour biology and behaviour, this study sought to determine the incidence and consequently the relevance of c-erb-B2, c-Myc, and H-ras gene alterations in tumour-free margins of oral squamous cell carcinoma (OSCC). Fifty samples of OSCC were analyzed for c-erb-B2 and c-Myc amplification by real-time polymerase chain reaction and for H-ras point mutations by sequencing. A relatively high incidence of genetic lesions was detected: 22% of cases had c-erb-B2 and 30% had c-Myc amplification, whilst only 12% harboured H-ras mutations. Kaplan-Meier analysis and the log-rank test showed statistically significant differences in 5-year survival rates and relapse between patients with tumour margins positive for c-erb-B2 amplification and those with margins that were negative (P = 0.002). H-ras and c-Myc alterations could not be associated with tumour behaviour. Molecular analysis of margins, targeting cancer genes, could identify additional, independent predictors of risk and outcome in OSCC.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma
VL  - 45
IS  - 6
SP  - 700
EP  - 705
DO  - 10.1016/j.ijom.2015.11.014
ER  - 
@article{
author = "Jelovac, Drago and Tepavčević, Zvezdana and Nikolić, Nadja and Ilić, Branislav and Eljabo, Najib and Popović, Branka and Čarkić, Jelena and Konstantinović, Vitomir and Vukadinović, Miroslav and Miličić, Biljana and Milašin, Jelena",
year = "2016",
abstract = "The tumour subtype, TNM classification, and histopathological data are sometimes not sufficient for understanding and assessing the behaviour of oral cancers. In an attempt to find additional markers of tumour biology and behaviour, this study sought to determine the incidence and consequently the relevance of c-erb-B2, c-Myc, and H-ras gene alterations in tumour-free margins of oral squamous cell carcinoma (OSCC). Fifty samples of OSCC were analyzed for c-erb-B2 and c-Myc amplification by real-time polymerase chain reaction and for H-ras point mutations by sequencing. A relatively high incidence of genetic lesions was detected: 22% of cases had c-erb-B2 and 30% had c-Myc amplification, whilst only 12% harboured H-ras mutations. Kaplan-Meier analysis and the log-rank test showed statistically significant differences in 5-year survival rates and relapse between patients with tumour margins positive for c-erb-B2 amplification and those with margins that were negative (P = 0.002). H-ras and c-Myc alterations could not be associated with tumour behaviour. Molecular analysis of margins, targeting cancer genes, could identify additional, independent predictors of risk and outcome in OSCC.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma",
volume = "45",
number = "6",
pages = "700-705",
doi = "10.1016/j.ijom.2015.11.014"
}
Jelovac, D., Tepavčević, Z., Nikolić, N., Ilić, B., Eljabo, N., Popović, B., Čarkić, J., Konstantinović, V., Vukadinović, M., Miličić, B.,& Milašin, J.. (2016). The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 45(6), 700-705.
https://doi.org/10.1016/j.ijom.2015.11.014
Jelovac D, Tepavčević Z, Nikolić N, Ilić B, Eljabo N, Popović B, Čarkić J, Konstantinović V, Vukadinović M, Miličić B, Milašin J. The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma. in International Journal of Oral & Maxillofacial Surgery. 2016;45(6):700-705.
doi:10.1016/j.ijom.2015.11.014 .
Jelovac, Drago, Tepavčević, Zvezdana, Nikolić, Nadja, Ilić, Branislav, Eljabo, Najib, Popović, Branka, Čarkić, Jelena, Konstantinović, Vitomir, Vukadinović, Miroslav, Miličić, Biljana, Milašin, Jelena, "The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma" in International Journal of Oral & Maxillofacial Surgery, 45, no. 6 (2016):700-705,
https://doi.org/10.1016/j.ijom.2015.11.014 . .
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12

High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors

Nikolić, Nadja; Aničić, Boban; Čarkić, Jelena; Simonović, Jelena; Toljić, Boško; Tanić, Nasta; Tepavčević, Zvezdana; Vukadinović, Miroslav; Konstantinović, Vitomir; Milašin, Jelena

(Pergamon-Elsevier Science Ltd, Oxford, 2015)

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Aničić, Boban
AU  - Čarkić, Jelena
AU  - Simonović, Jelena
AU  - Toljić, Boško
AU  - Tanić, Nasta
AU  - Tepavčević, Zvezdana
AU  - Vukadinović, Miroslav
AU  - Konstantinović, Vitomir
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2019
AB  - Objectives: to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands. Materials and Methods: Genomic DNA from paraffin-embedded samples of 50 pleomorphic adenomas and 10 carcinomas ex pleomorphic adenoma was subjected to methylation specific polymerase chain reaction for hypermethylation analyses and real time polymerase chain reaction for the relative telomere length calculations. Results: Promoter hypermethylation of the two genes was a very frequent event in both neoplasms between 60% and 90% of samples were hypermethylated - but without significant difference between the groups. The mean relative telomere length in the pleomorphic adenoma group was significantly increased in comparison to the control group (P = 0.00), and significantly decreased in comparison to the carcinoma group (P = 0.05). Telomeres were also longer in myxoid and cellular histological subtypes of adenomas than in the classic type (P = 0.044 and P = 0.018, respectively). Longer telomeres were more frequent in tumors with hypermethylated p14(ARF) alleles (P = 0.013). Conclusion: Promoter hypermethylations seems to be an important mechanism of p16(INK4a) and Pl4(ARF) inactivation in parotid gland tumors. Telomeric lengthening appears to be involved in the pathogenesis of both benign and malignant tumors of the parotid glands.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Archives of Oral Biology
T1  - High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors
VL  - 60
IS  - 11
SP  - 1662
EP  - 1666
DO  - 10.1016/j.archoralbio.2015.08.011
ER  - 
@article{
author = "Nikolić, Nadja and Aničić, Boban and Čarkić, Jelena and Simonović, Jelena and Toljić, Boško and Tanić, Nasta and Tepavčević, Zvezdana and Vukadinović, Miroslav and Konstantinović, Vitomir and Milašin, Jelena",
year = "2015",
abstract = "Objectives: to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands. Materials and Methods: Genomic DNA from paraffin-embedded samples of 50 pleomorphic adenomas and 10 carcinomas ex pleomorphic adenoma was subjected to methylation specific polymerase chain reaction for hypermethylation analyses and real time polymerase chain reaction for the relative telomere length calculations. Results: Promoter hypermethylation of the two genes was a very frequent event in both neoplasms between 60% and 90% of samples were hypermethylated - but without significant difference between the groups. The mean relative telomere length in the pleomorphic adenoma group was significantly increased in comparison to the control group (P = 0.00), and significantly decreased in comparison to the carcinoma group (P = 0.05). Telomeres were also longer in myxoid and cellular histological subtypes of adenomas than in the classic type (P = 0.044 and P = 0.018, respectively). Longer telomeres were more frequent in tumors with hypermethylated p14(ARF) alleles (P = 0.013). Conclusion: Promoter hypermethylations seems to be an important mechanism of p16(INK4a) and Pl4(ARF) inactivation in parotid gland tumors. Telomeric lengthening appears to be involved in the pathogenesis of both benign and malignant tumors of the parotid glands.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Archives of Oral Biology",
title = "High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors",
volume = "60",
number = "11",
pages = "1662-1666",
doi = "10.1016/j.archoralbio.2015.08.011"
}
Nikolić, N., Aničić, B., Čarkić, J., Simonović, J., Toljić, B., Tanić, N., Tepavčević, Z., Vukadinović, M., Konstantinović, V.,& Milašin, J.. (2015). High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors. in Archives of Oral Biology
Pergamon-Elsevier Science Ltd, Oxford., 60(11), 1662-1666.
https://doi.org/10.1016/j.archoralbio.2015.08.011
Nikolić N, Aničić B, Čarkić J, Simonović J, Toljić B, Tanić N, Tepavčević Z, Vukadinović M, Konstantinović V, Milašin J. High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors. in Archives of Oral Biology. 2015;60(11):1662-1666.
doi:10.1016/j.archoralbio.2015.08.011 .
Nikolić, Nadja, Aničić, Boban, Čarkić, Jelena, Simonović, Jelena, Toljić, Boško, Tanić, Nasta, Tepavčević, Zvezdana, Vukadinović, Miroslav, Konstantinović, Vitomir, Milašin, Jelena, "High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors" in Archives of Oral Biology, 60, no. 11 (2015):1662-1666,
https://doi.org/10.1016/j.archoralbio.2015.08.011 . .
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An attempt to create a standardized (reference) model for experimental investigations on implant's sample

Tanasić, Ivan; Tihaček-Šojić, Ljiljana; Mitrović, Nenad; Milić-Lemić, Aleksandra; Vukadinović, Miroslav; Marković, Aleksa; Milošević, Miloš

(Elsevier Sci Ltd, Oxford, 2015)

TY  - JOUR
AU  - Tanasić, Ivan
AU  - Tihaček-Šojić, Ljiljana
AU  - Mitrović, Nenad
AU  - Milić-Lemić, Aleksandra
AU  - Vukadinović, Miroslav
AU  - Marković, Aleksa
AU  - Milošević, Miloš
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1965
AB  - The aim of this study was to determine, evaluate and measure strain of vertically loaded implant using the digital image correlation method. The Straumann (R) dental implant system with the SLActive (R) surface was used in this study. Implant was immersed in poly-methyl-methacrylate during his hardening process. After preparation procedure a sample of implant and poly-methyl-methacrylate was obtained. This sample was loaded using external load from 0 to 400 N. Maximum strain in the 4 mm surface layer was 0.30% whereas maximum strain in the 6 mm surface layer (opposite side) was 0.20%, detected in the marginal and apical part of implant-poly-methyl-methacrylate sample. Minimum strain measured by Aramis software was 0.01%, detected in the 4 mm surface layer. According to results obtained by Aramis data processing, the 4 mm surface layer indicated higher overall strain in apical direction with the strains of 0.18-0.21%. Increasing the load did not affect the value of maximum strain however, higher load influenced the overall strain concentration increased especially in marginal and apical part of the sample surfaces that surrounded lateral sides of implant body.
PB  - Elsevier Sci Ltd, Oxford
T2  - Measurement
T1  - An attempt to create a standardized (reference) model for experimental investigations on implant's sample
VL  - 72
SP  - 37
EP  - 42
DO  - 10.1016/j.measurement.2015.04.029
ER  - 
@article{
author = "Tanasić, Ivan and Tihaček-Šojić, Ljiljana and Mitrović, Nenad and Milić-Lemić, Aleksandra and Vukadinović, Miroslav and Marković, Aleksa and Milošević, Miloš",
year = "2015",
abstract = "The aim of this study was to determine, evaluate and measure strain of vertically loaded implant using the digital image correlation method. The Straumann (R) dental implant system with the SLActive (R) surface was used in this study. Implant was immersed in poly-methyl-methacrylate during his hardening process. After preparation procedure a sample of implant and poly-methyl-methacrylate was obtained. This sample was loaded using external load from 0 to 400 N. Maximum strain in the 4 mm surface layer was 0.30% whereas maximum strain in the 6 mm surface layer (opposite side) was 0.20%, detected in the marginal and apical part of implant-poly-methyl-methacrylate sample. Minimum strain measured by Aramis software was 0.01%, detected in the 4 mm surface layer. According to results obtained by Aramis data processing, the 4 mm surface layer indicated higher overall strain in apical direction with the strains of 0.18-0.21%. Increasing the load did not affect the value of maximum strain however, higher load influenced the overall strain concentration increased especially in marginal and apical part of the sample surfaces that surrounded lateral sides of implant body.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Measurement",
title = "An attempt to create a standardized (reference) model for experimental investigations on implant's sample",
volume = "72",
pages = "37-42",
doi = "10.1016/j.measurement.2015.04.029"
}
Tanasić, I., Tihaček-Šojić, L., Mitrović, N., Milić-Lemić, A., Vukadinović, M., Marković, A.,& Milošević, M.. (2015). An attempt to create a standardized (reference) model for experimental investigations on implant's sample. in Measurement
Elsevier Sci Ltd, Oxford., 72, 37-42.
https://doi.org/10.1016/j.measurement.2015.04.029
Tanasić I, Tihaček-Šojić L, Mitrović N, Milić-Lemić A, Vukadinović M, Marković A, Milošević M. An attempt to create a standardized (reference) model for experimental investigations on implant's sample. in Measurement. 2015;72:37-42.
doi:10.1016/j.measurement.2015.04.029 .
Tanasić, Ivan, Tihaček-Šojić, Ljiljana, Mitrović, Nenad, Milić-Lemić, Aleksandra, Vukadinović, Miroslav, Marković, Aleksa, Milošević, Miloš, "An attempt to create a standardized (reference) model for experimental investigations on implant's sample" in Measurement, 72 (2015):37-42,
https://doi.org/10.1016/j.measurement.2015.04.029 . .
13
9
18

Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma

Ilic-Dimitrijević, Ivana; Loening, Thomas; Falk, Marcus; Konstantinović, Vitomir; Vukadinović, Miroslav; Tepavčević, Zvezdana; Tabaković, Saša Z.; Pejčić, Nataša; Miličić, Biljana; Milašin, Jelena

(Društvo genetičara Srbije, Beograd, 2014)

TY  - JOUR
AU  - Ilic-Dimitrijević, Ivana
AU  - Loening, Thomas
AU  - Falk, Marcus
AU  - Konstantinović, Vitomir
AU  - Vukadinović, Miroslav
AU  - Tepavčević, Zvezdana
AU  - Tabaković, Saša Z.
AU  - Pejčić, Nataša
AU  - Miličić, Biljana
AU  - Milašin, Jelena
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1926
AB  - Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas.
PB  - Društvo genetičara Srbije, Beograd
T2  - Genetika - Belgrade
T1  - Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma
VL  - 46
IS  - 2
SP  - 601
EP  - 610
DO  - 10.2298/GENSR1402601D
ER  - 
@article{
author = "Ilic-Dimitrijević, Ivana and Loening, Thomas and Falk, Marcus and Konstantinović, Vitomir and Vukadinović, Miroslav and Tepavčević, Zvezdana and Tabaković, Saša Z. and Pejčić, Nataša and Miličić, Biljana and Milašin, Jelena",
year = "2014",
abstract = "Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas.",
publisher = "Društvo genetičara Srbije, Beograd",
journal = "Genetika - Belgrade",
title = "Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma",
volume = "46",
number = "2",
pages = "601-610",
doi = "10.2298/GENSR1402601D"
}
Ilic-Dimitrijević, I., Loening, T., Falk, M., Konstantinović, V., Vukadinović, M., Tepavčević, Z., Tabaković, S. Z., Pejčić, N., Miličić, B.,& Milašin, J.. (2014). Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma. in Genetika - Belgrade
Društvo genetičara Srbije, Beograd., 46(2), 601-610.
https://doi.org/10.2298/GENSR1402601D
Ilic-Dimitrijević I, Loening T, Falk M, Konstantinović V, Vukadinović M, Tepavčević Z, Tabaković SZ, Pejčić N, Miličić B, Milašin J. Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma. in Genetika - Belgrade. 2014;46(2):601-610.
doi:10.2298/GENSR1402601D .
Ilic-Dimitrijević, Ivana, Loening, Thomas, Falk, Marcus, Konstantinović, Vitomir, Vukadinović, Miroslav, Tepavčević, Zvezdana, Tabaković, Saša Z., Pejčić, Nataša, Miličić, Biljana, Milašin, Jelena, "Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma" in Genetika - Belgrade, 46, no. 2 (2014):601-610,
https://doi.org/10.2298/GENSR1402601D . .
6
3
6

Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands

Nikolić, Nadja; Aničić, Boban; Tepavčević, Zvezdana; Jezdić, Zoran; Čarkić, Jelena; Toljić, Boško; Dedović-Tanić, Nasta; Konstantinović, Vitomir; Vukadinović, Miroslav; Milašin, Jelena

(Društvo medicinskih biohemičara Srbije, Beograd i Versita, 2013)

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Aničić, Boban
AU  - Tepavčević, Zvezdana
AU  - Jezdić, Zoran
AU  - Čarkić, Jelena
AU  - Toljić, Boško
AU  - Dedović-Tanić, Nasta
AU  - Konstantinović, Vitomir
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1779
AB  - Background: Genetic studies of salivary gland neoplasms were mainly focused on chromosomal changes, and some specific patterns of chromosome translocations have been described. However, molecular alterations, in particular the role of HER-2/H-ras/c-myc signalling cascade in pleomorphic adenoma pathogenesis (PA), are less well characterized. In addition, data on single nucleotide polymorphisms (SNPs) as potential susceptibility factors for PA development are also quite scarce. Methods: Mutational analyses were performed by means of real-time PCR (HER-2 and c-myc amplification analysis), PCR-SSCP and sequencing (H-ras point mutation detection). Polymorphisms analysis was performed by PCR-RFLP (survivin and MMP-9 genes). Results: Amplification of HER-2 and c-myc has been found in 13% and 9% of PA cases respectively. Point mutations in H-ras codons 12/13 have been detected in 17% of PAs. No correlation could be established between these alterations and clinical characteristics of PAs, whereas they might play a role in a subset of malignant salivary gland tumours. As for survivin -31 G/C polymorphism, C allele carriers had a 4-fold decrease of the risk of developing PA (p=0.05). Carriers of the variant allele T of the -1562C/T SNP in MMP-9 gene had a 4-fold increase of the risk of developing PA (p lt 0.001). Conclusions: A longer follow-up of PA patients harbouring mutations could uncover a prognostic role of HER-2 and c-myc amplification as predictors of adenoma transformation into carcinoma. Both survivin and MMP-9 promoter polymorphisms represent susceptibility factors for the development of PAs in the Serbian population.
AB  - Uvod: U ispitivanjima mehanizama nastanka tumora pljuvačnih žlezda uglavnom dominiraju citogenetičke studije, pa su tako detektovane i opisane različite hromozomske translokacije sa specifičnim obrascem javljanja. Međutim, molekularne promene u ovim tumorima i dalje su relativno slabo poznate, a pogotovo je malo podataka o potencijalnom značaju signalnog puta HER-2/H-ras/c-myc u razvoju i progresiji pleomorfnih adenoma (PA). Takođe, retki su i podaci 0 polimorfizmima pojedinačnog nukleotida (SNP) kao faktora predispozicije za nastanak PA. Metode: Analize somatskih mutacija urađene su metodama real-time PCR (analiza amplifikacije HER-2 i c-myc), PCR-SSCP i sekvenciranja (detekcija tačkastih mutacija u H-ras). Ana I iza polimorfizama pojedinačnih nukleotida (SNP) vršena je prime- nom metode PCR-RFLP (u genima za survivin i MMP-9). Rezultati: Amplifikacija gena HER-2 detektovana je u 13%, c-myc u 9% a tačkaste mutacije u kodonima 12/13 H-ras gena u 17% uzoraka. Nije ustanovljena veza između ovih promena i kliničkih odlika adenoma. Na malom uzorku karcinoma, pokazano je da je amplifikacija HER-2 povezana sa recidivima tumora. Nosioci C alela u -31G/C SNP gena za survivin imaju četiri puta manji rizik od nastanka PA (p=0,05), dok nosioci varijantnog alela T kod -1562 C/T SNP u MMP-9 genu imaju četiri puta veći rizik da obole od PA u odnosu na kontrolu (p lt 0,001). Zaključak: Dužim praćenjem pacijenata sa PA mogla bi da se ustanovi prognostička uloga HER-2 i c-myc amplifikacija kao indikatora za transformaciju adenoma u karcinom. Polimorfizmi u promotorima gena za survivin i MMP-9 predstavljaju modulatore rizika za razvoj pleomorfnih adenoma u srpskoj populaciji.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands
T1  - Somatske mutacije i analiza polimorfizama u pleomorfnim adenomima pljuvačnih žlezda
VL  - 32
IS  - 4
SP  - 354
EP  - 360
DO  - 10.2478/jomb-2013-0048
ER  - 
@article{
author = "Nikolić, Nadja and Aničić, Boban and Tepavčević, Zvezdana and Jezdić, Zoran and Čarkić, Jelena and Toljić, Boško and Dedović-Tanić, Nasta and Konstantinović, Vitomir and Vukadinović, Miroslav and Milašin, Jelena",
year = "2013",
abstract = "Background: Genetic studies of salivary gland neoplasms were mainly focused on chromosomal changes, and some specific patterns of chromosome translocations have been described. However, molecular alterations, in particular the role of HER-2/H-ras/c-myc signalling cascade in pleomorphic adenoma pathogenesis (PA), are less well characterized. In addition, data on single nucleotide polymorphisms (SNPs) as potential susceptibility factors for PA development are also quite scarce. Methods: Mutational analyses were performed by means of real-time PCR (HER-2 and c-myc amplification analysis), PCR-SSCP and sequencing (H-ras point mutation detection). Polymorphisms analysis was performed by PCR-RFLP (survivin and MMP-9 genes). Results: Amplification of HER-2 and c-myc has been found in 13% and 9% of PA cases respectively. Point mutations in H-ras codons 12/13 have been detected in 17% of PAs. No correlation could be established between these alterations and clinical characteristics of PAs, whereas they might play a role in a subset of malignant salivary gland tumours. As for survivin -31 G/C polymorphism, C allele carriers had a 4-fold decrease of the risk of developing PA (p=0.05). Carriers of the variant allele T of the -1562C/T SNP in MMP-9 gene had a 4-fold increase of the risk of developing PA (p lt 0.001). Conclusions: A longer follow-up of PA patients harbouring mutations could uncover a prognostic role of HER-2 and c-myc amplification as predictors of adenoma transformation into carcinoma. Both survivin and MMP-9 promoter polymorphisms represent susceptibility factors for the development of PAs in the Serbian population., Uvod: U ispitivanjima mehanizama nastanka tumora pljuvačnih žlezda uglavnom dominiraju citogenetičke studije, pa su tako detektovane i opisane različite hromozomske translokacije sa specifičnim obrascem javljanja. Međutim, molekularne promene u ovim tumorima i dalje su relativno slabo poznate, a pogotovo je malo podataka o potencijalnom značaju signalnog puta HER-2/H-ras/c-myc u razvoju i progresiji pleomorfnih adenoma (PA). Takođe, retki su i podaci 0 polimorfizmima pojedinačnog nukleotida (SNP) kao faktora predispozicije za nastanak PA. Metode: Analize somatskih mutacija urađene su metodama real-time PCR (analiza amplifikacije HER-2 i c-myc), PCR-SSCP i sekvenciranja (detekcija tačkastih mutacija u H-ras). Ana I iza polimorfizama pojedinačnih nukleotida (SNP) vršena je prime- nom metode PCR-RFLP (u genima za survivin i MMP-9). Rezultati: Amplifikacija gena HER-2 detektovana je u 13%, c-myc u 9% a tačkaste mutacije u kodonima 12/13 H-ras gena u 17% uzoraka. Nije ustanovljena veza između ovih promena i kliničkih odlika adenoma. Na malom uzorku karcinoma, pokazano je da je amplifikacija HER-2 povezana sa recidivima tumora. Nosioci C alela u -31G/C SNP gena za survivin imaju četiri puta manji rizik od nastanka PA (p=0,05), dok nosioci varijantnog alela T kod -1562 C/T SNP u MMP-9 genu imaju četiri puta veći rizik da obole od PA u odnosu na kontrolu (p lt 0,001). Zaključak: Dužim praćenjem pacijenata sa PA mogla bi da se ustanovi prognostička uloga HER-2 i c-myc amplifikacija kao indikatora za transformaciju adenoma u karcinom. Polimorfizmi u promotorima gena za survivin i MMP-9 predstavljaju modulatore rizika za razvoj pleomorfnih adenoma u srpskoj populaciji.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands, Somatske mutacije i analiza polimorfizama u pleomorfnim adenomima pljuvačnih žlezda",
volume = "32",
number = "4",
pages = "354-360",
doi = "10.2478/jomb-2013-0048"
}
Nikolić, N., Aničić, B., Tepavčević, Z., Jezdić, Z., Čarkić, J., Toljić, B., Dedović-Tanić, N., Konstantinović, V., Vukadinović, M.,& Milašin, J.. (2013). Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 32(4), 354-360.
https://doi.org/10.2478/jomb-2013-0048
Nikolić N, Aničić B, Tepavčević Z, Jezdić Z, Čarkić J, Toljić B, Dedović-Tanić N, Konstantinović V, Vukadinović M, Milašin J. Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands. in Journal of Medical Biochemistry. 2013;32(4):354-360.
doi:10.2478/jomb-2013-0048 .
Nikolić, Nadja, Aničić, Boban, Tepavčević, Zvezdana, Jezdić, Zoran, Čarkić, Jelena, Toljić, Boško, Dedović-Tanić, Nasta, Konstantinović, Vitomir, Vukadinović, Miroslav, Milašin, Jelena, "Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands" in Journal of Medical Biochemistry, 32, no. 4 (2013):354-360,
https://doi.org/10.2478/jomb-2013-0048 . .
4
6
7

Analysis of polymorphism in the survivin gene promoter as a potential risk factor for head and neck cancers development

Kostić, Marija; Nikolić, Nadja; Ilić, Branislav; Čarkić, Jelena; Milenković, Sanja; Vukadinović, Miroslav

(Srpsko lekarsko društvo, Beograd, 2013)

TY  - JOUR
AU  - Kostić, Marija
AU  - Nikolić, Nadja
AU  - Ilić, Branislav
AU  - Čarkić, Jelena
AU  - Milenković, Sanja
AU  - Vukadinović, Miroslav
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1797
AB  - Introduction. Association studies have shown that gene polymorphisms in various classes of genes can modulate cancer risk. The -31G/C polymorphism in the promoter of survivin gene, affects the expression of the anti-apoptotic protein survivin which in turn may predispose an individual to some types of cancer. Objective. The aim of the study was to determine whether the survivin promoter -31G/C polymorphism could be a susceptibility factor for squamous cell carcinoma (SCC) of the oral cavity and basal cell carcinoma (BCC) of the skin. Methods. The DNA obtained from 88 patients with SCC, 60 patients with BCC and 111 healthy individuals was subjected to polymerase chain reaction-restriction fragment length polymorphism analysis (PCR- RFLP) in order to determine genotype and allele frequencies in patients and control groups. Logistic regression was used for cancer risk assessment. Results. The following distribution of genotypes was obtained: CC genotype 15% in the SCC group, 13% in the BCC group and 12% in controls; CG genotype 41% in SCCs, 35% in BCCs, 48% in controls; GG genotype 44% in SCCs, 52% in BCCs and 40% in controls. Allelic frequencies were as follows: G allele 0.65 in SCCs, 0.69 in BCCs and 0.64 in the control group; C allele 0.35 in SCCs, 0.31 in BCCs and 0.36 in the control group. There was no statistically significant difference in allele or genotype frequencies between the patients and controls (p>0.05). Conclusion. In Serbian population, -31G/C polymorphism in the promoter of the survivin gene cannot be considered as a risk factor for oral squamous cell carcinoma and skin basal cell carcinoma.
AB  - Uvod. Dokazano je da polimorfizmi u različitim klasama gena mogu da povećaju rizik za razvoj malignih tumora, između ostalih i skvamocelularnog karcinoma (SCC) usne duplje i bazocelularnog karcinoma (BCC) kože. Survivin je bifunkcionalni protein-inhibitor apoptoze i regulator ćelijskog ciklusa. Otkriveno je više funkcionalnih polimorfizama u ovom genu, a jedan od ključnih je polimorfizam G/C na poziciji -31, za koji je pokazano da je modulator ekspresije survivina i da doprinosi povećanju rizika od obolevanja od različitih tipova tumora. Cilj rada. Cilj rada je bio da se analizira učestalost genotipova i alela za -31G/C polimorfizam gena za survivin kod osoba obolelih od SCC i BCC i kod zdravih ispitanika. Logističkom regresionom analizom ispitana je povezanost ovog polimorfizma i rizika za nastanak SCC i BCC. Metode rada. Učestalosti alela i genotipova kod 88 osoba obolelih od SCC, 60 osoba obolelih od BCC i 111 zdravih ispitanika određene su lančanom reakcijom polimeraze i restrikcionom analizom. Logističkom regresijom procenjena je sklonost ka razvoju SCC i BCC. Rezultati. Genotip CC je utvrđen kod 15% ispitanika sa SCC, 13% sa BCC i 12% zdavih osoba. Genotip CG je zabeležen kod 41% ispitanika sa SCC, 35% sa BCC i 48% zdravih osoba. Genotip GG je otkriven kod 44% osoba sa SCC, 52% sa BCC i 40% zdravih ispitanika. Učestalost G-alela bila je sledeća: 0,65 kod ispitanika sa SCC, 0,69 kod ispitanika sa BCC i 0,64 u grupi zdravih osoba. Učestalost C-alela bila je: 0,35 kod ispitanika sa SCC, 0,31 kod ispitanika sa BCC i 0,36 u grupi zdravih osoba. Nije bilo statistički značajne razlike u raspodeli genotipova i alela između bolesnika s karcinomima i zdravih ispitanika (p>0,05). Zaključak. Polimorfizam -31G/C u promotoru gena za survivin ne može se smatrati faktorom rizika za razvoj ova dva tipa tumora.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Analysis of polymorphism in the survivin gene promoter as a potential risk factor for head and neck cancers development
T1  - Analiza polimorfizma u promotoru gena za survivin kao mogućeg faktora rizika za nastanak tumora glave i vrata
VL  - 141
IS  - 5-6
SP  - 304
EP  - 307
DO  - 10.2298/SARH1306304K
ER  - 
@article{
author = "Kostić, Marija and Nikolić, Nadja and Ilić, Branislav and Čarkić, Jelena and Milenković, Sanja and Vukadinović, Miroslav",
year = "2013",
abstract = "Introduction. Association studies have shown that gene polymorphisms in various classes of genes can modulate cancer risk. The -31G/C polymorphism in the promoter of survivin gene, affects the expression of the anti-apoptotic protein survivin which in turn may predispose an individual to some types of cancer. Objective. The aim of the study was to determine whether the survivin promoter -31G/C polymorphism could be a susceptibility factor for squamous cell carcinoma (SCC) of the oral cavity and basal cell carcinoma (BCC) of the skin. Methods. The DNA obtained from 88 patients with SCC, 60 patients with BCC and 111 healthy individuals was subjected to polymerase chain reaction-restriction fragment length polymorphism analysis (PCR- RFLP) in order to determine genotype and allele frequencies in patients and control groups. Logistic regression was used for cancer risk assessment. Results. The following distribution of genotypes was obtained: CC genotype 15% in the SCC group, 13% in the BCC group and 12% in controls; CG genotype 41% in SCCs, 35% in BCCs, 48% in controls; GG genotype 44% in SCCs, 52% in BCCs and 40% in controls. Allelic frequencies were as follows: G allele 0.65 in SCCs, 0.69 in BCCs and 0.64 in the control group; C allele 0.35 in SCCs, 0.31 in BCCs and 0.36 in the control group. There was no statistically significant difference in allele or genotype frequencies between the patients and controls (p>0.05). Conclusion. In Serbian population, -31G/C polymorphism in the promoter of the survivin gene cannot be considered as a risk factor for oral squamous cell carcinoma and skin basal cell carcinoma., Uvod. Dokazano je da polimorfizmi u različitim klasama gena mogu da povećaju rizik za razvoj malignih tumora, između ostalih i skvamocelularnog karcinoma (SCC) usne duplje i bazocelularnog karcinoma (BCC) kože. Survivin je bifunkcionalni protein-inhibitor apoptoze i regulator ćelijskog ciklusa. Otkriveno je više funkcionalnih polimorfizama u ovom genu, a jedan od ključnih je polimorfizam G/C na poziciji -31, za koji je pokazano da je modulator ekspresije survivina i da doprinosi povećanju rizika od obolevanja od različitih tipova tumora. Cilj rada. Cilj rada je bio da se analizira učestalost genotipova i alela za -31G/C polimorfizam gena za survivin kod osoba obolelih od SCC i BCC i kod zdravih ispitanika. Logističkom regresionom analizom ispitana je povezanost ovog polimorfizma i rizika za nastanak SCC i BCC. Metode rada. Učestalosti alela i genotipova kod 88 osoba obolelih od SCC, 60 osoba obolelih od BCC i 111 zdravih ispitanika određene su lančanom reakcijom polimeraze i restrikcionom analizom. Logističkom regresijom procenjena je sklonost ka razvoju SCC i BCC. Rezultati. Genotip CC je utvrđen kod 15% ispitanika sa SCC, 13% sa BCC i 12% zdavih osoba. Genotip CG je zabeležen kod 41% ispitanika sa SCC, 35% sa BCC i 48% zdravih osoba. Genotip GG je otkriven kod 44% osoba sa SCC, 52% sa BCC i 40% zdravih ispitanika. Učestalost G-alela bila je sledeća: 0,65 kod ispitanika sa SCC, 0,69 kod ispitanika sa BCC i 0,64 u grupi zdravih osoba. Učestalost C-alela bila je: 0,35 kod ispitanika sa SCC, 0,31 kod ispitanika sa BCC i 0,36 u grupi zdravih osoba. Nije bilo statistički značajne razlike u raspodeli genotipova i alela između bolesnika s karcinomima i zdravih ispitanika (p>0,05). Zaključak. Polimorfizam -31G/C u promotoru gena za survivin ne može se smatrati faktorom rizika za razvoj ova dva tipa tumora.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Analysis of polymorphism in the survivin gene promoter as a potential risk factor for head and neck cancers development, Analiza polimorfizma u promotoru gena za survivin kao mogućeg faktora rizika za nastanak tumora glave i vrata",
volume = "141",
number = "5-6",
pages = "304-307",
doi = "10.2298/SARH1306304K"
}
Kostić, M., Nikolić, N., Ilić, B., Čarkić, J., Milenković, S.,& Vukadinović, M.. (2013). Analysis of polymorphism in the survivin gene promoter as a potential risk factor for head and neck cancers development. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 141(5-6), 304-307.
https://doi.org/10.2298/SARH1306304K
Kostić M, Nikolić N, Ilić B, Čarkić J, Milenković S, Vukadinović M. Analysis of polymorphism in the survivin gene promoter as a potential risk factor for head and neck cancers development. in Srpski arhiv za celokupno lekarstvo. 2013;141(5-6):304-307.
doi:10.2298/SARH1306304K .
Kostić, Marija, Nikolić, Nadja, Ilić, Branislav, Čarkić, Jelena, Milenković, Sanja, Vukadinović, Miroslav, "Analysis of polymorphism in the survivin gene promoter as a potential risk factor for head and neck cancers development" in Srpski arhiv za celokupno lekarstvo, 141, no. 5-6 (2013):304-307,
https://doi.org/10.2298/SARH1306304K . .
16
10
15

TP53 and c-myc Co-alterations: A hallmark of oral cancer progression

Tanić, Nasta; Milašin, Jelena; Dramićanin, Tatjana; Bošković, Maja; Vukadinović, Miroslav; Milošević, Verica; Tanić, Nikola

(Društvo medicinskih biohemičara Srbije, Beograd i Versita, 2013)

TY  - JOUR
AU  - Tanić, Nasta
AU  - Milašin, Jelena
AU  - Dramićanin, Tatjana
AU  - Bošković, Maja
AU  - Vukadinović, Miroslav
AU  - Milošević, Verica
AU  - Tanić, Nikola
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1780
AB  - Background: Head and neck squamous cell carcinoma, including oral cancer, is the sixth most common cancer worldwide. Despite advances in surgery and treatment, the 5-year survival rate has not improved significantly. Therefore, reliable molecular markers for oral cancer progression are badly needed. Methods: We conducted a copy number analysis to estimate amplification status of c-myc, cycD1 and EGFR oncogenes, mutational PCR-SSCP analysis to determine activation of H-ras oncogene and inactivation of TP53 tumour suppressor gene and methylation specific PCR analysis to evaluate hypermethylation of p16 and MGMT genes. Results: c-myc oncogene was amplified in 56.7%, cycDI in 20% and EGFR in 16.7% of Oral Squamous Cell Carcinoma (OSCC) cases while H-ras was activated in 33.3% of samples. Amplification of c-myc was significantly associated with the tumour grade 2. Interestingly, EGFR and H-ras alterations were mutually exclusive. p16 and MGMT were inactivated by hypermethylation in 30% and 13.3% of cases. Co-alteration of cycDI and p16 were not observed in any of the analyzed samples. TP53 was inactivated in 56.7% of samples and was significantly associated with progression of OSCC, grade 2 and stage 2. Moreover, TP53 and c-myc oncogene were simultaneously altered in grade 2 OSCC. Conclusions: The most promising marker of OSCC progression remains the TP53 tumour suppressor, which is the most frequently mutated gene in oral cancers. Since there is synergism between TP53 and c-myc, it seems that co-alteration of these two genes could be also a good marker of OSCC progression from grade1 to grade 2 tumours.
AB  - Uvod: Skvamocelularni karcinomi glave i vrata (HNSCC) uključujući i skvamocelularni karcinom usne duplje (OSCC) ubrajaju se u šest najčešćih tipova humanih maligniteta. Uprkos značajnim napredcima u hirurškom i terapijskom tretmanu, stopa petogodišnjeg preživljavanja kod ovog tipa maligniteta nije značajnije popravljena. Upravo zato, definisanje pouzdanih molekularnih markera progresije kod OSSC predstavlja apsolutni prioritetet. Metode: Amplifikacioni status c-myc, cycD1 i EGFR gena određen je pomoću eseja za detekciju broja genskih kopija, aktivacija H-ras onkogena i inaktivacija TP53 tumor supresora određena je PCR-SSCP mutacionom analizom, a hipermetilacija promotora p16 i MGMT gena je ispitana metil specifičnim PCR-om (MSP). Rezultati: Amplifikacija c-myc onkogena detektovana je kod 56,7%, cycD1 onkogena kod 20%, a EGFR onkogena kod 16,7% analiziranih oralnih skvamocelularnih carcinoma. Istovremeno, mutaciona aktivacija H-ras onkogena detektovana je kod 33,3% ispitanih uzoraka. Amplifikovani c-myc, statistički značajno korelira sa gradusom 2 OSCC. Posebno intrigantan je bio nalaz po kom se onkogene aktivacije u EGFR i H-ras genu međusobno isključuju. Hipermetilacija promotora p16 gena detektovana je kod 30%, a MGMT kod 13,3% analiziranih uzoraka. Ko-alteracije cycDI i p16 gena nisu zapažene ni u jednom od analiziranih uzoraka. Inaktivacija TP53 gena detektovana je kod 56,7% uzoraka i utvrđeno je da statistički značajno korelira sa gradusom 2 i statusom 2 OSCC. Pored ovoga, utvrđeno je da statistički značajan broj uzoraka gradusa 2, sa aktiviranim TP53 genom ima istovremeno aktiviran i c-myc onkogen. Zaključak: TP53, najčešće mutirani gen u oralnim karcinomima, ostaje za sada i najpouzdaniji marker progresije kod OSCC. Obzirom na detektovani sinergizam između TP53 i c-myc gena, možemo reći da su istovremene promene u ova dva gena još pouzdaniji pokazatelj progresije OSSC iz gradusa 1 u gradus 2.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - TP53 and c-myc Co-alterations: A hallmark of oral cancer progression
T1  - Simultana alteracija TP53 i c-myc gena - obeležje progresije oralnih karcinoma
VL  - 32
IS  - 4
SP  - 380
EP  - 388
DO  - 10.2478/jomb-2014-0009
ER  - 
@article{
author = "Tanić, Nasta and Milašin, Jelena and Dramićanin, Tatjana and Bošković, Maja and Vukadinović, Miroslav and Milošević, Verica and Tanić, Nikola",
year = "2013",
abstract = "Background: Head and neck squamous cell carcinoma, including oral cancer, is the sixth most common cancer worldwide. Despite advances in surgery and treatment, the 5-year survival rate has not improved significantly. Therefore, reliable molecular markers for oral cancer progression are badly needed. Methods: We conducted a copy number analysis to estimate amplification status of c-myc, cycD1 and EGFR oncogenes, mutational PCR-SSCP analysis to determine activation of H-ras oncogene and inactivation of TP53 tumour suppressor gene and methylation specific PCR analysis to evaluate hypermethylation of p16 and MGMT genes. Results: c-myc oncogene was amplified in 56.7%, cycDI in 20% and EGFR in 16.7% of Oral Squamous Cell Carcinoma (OSCC) cases while H-ras was activated in 33.3% of samples. Amplification of c-myc was significantly associated with the tumour grade 2. Interestingly, EGFR and H-ras alterations were mutually exclusive. p16 and MGMT were inactivated by hypermethylation in 30% and 13.3% of cases. Co-alteration of cycDI and p16 were not observed in any of the analyzed samples. TP53 was inactivated in 56.7% of samples and was significantly associated with progression of OSCC, grade 2 and stage 2. Moreover, TP53 and c-myc oncogene were simultaneously altered in grade 2 OSCC. Conclusions: The most promising marker of OSCC progression remains the TP53 tumour suppressor, which is the most frequently mutated gene in oral cancers. Since there is synergism between TP53 and c-myc, it seems that co-alteration of these two genes could be also a good marker of OSCC progression from grade1 to grade 2 tumours., Uvod: Skvamocelularni karcinomi glave i vrata (HNSCC) uključujući i skvamocelularni karcinom usne duplje (OSCC) ubrajaju se u šest najčešćih tipova humanih maligniteta. Uprkos značajnim napredcima u hirurškom i terapijskom tretmanu, stopa petogodišnjeg preživljavanja kod ovog tipa maligniteta nije značajnije popravljena. Upravo zato, definisanje pouzdanih molekularnih markera progresije kod OSSC predstavlja apsolutni prioritetet. Metode: Amplifikacioni status c-myc, cycD1 i EGFR gena određen je pomoću eseja za detekciju broja genskih kopija, aktivacija H-ras onkogena i inaktivacija TP53 tumor supresora određena je PCR-SSCP mutacionom analizom, a hipermetilacija promotora p16 i MGMT gena je ispitana metil specifičnim PCR-om (MSP). Rezultati: Amplifikacija c-myc onkogena detektovana je kod 56,7%, cycD1 onkogena kod 20%, a EGFR onkogena kod 16,7% analiziranih oralnih skvamocelularnih carcinoma. Istovremeno, mutaciona aktivacija H-ras onkogena detektovana je kod 33,3% ispitanih uzoraka. Amplifikovani c-myc, statistički značajno korelira sa gradusom 2 OSCC. Posebno intrigantan je bio nalaz po kom se onkogene aktivacije u EGFR i H-ras genu međusobno isključuju. Hipermetilacija promotora p16 gena detektovana je kod 30%, a MGMT kod 13,3% analiziranih uzoraka. Ko-alteracije cycDI i p16 gena nisu zapažene ni u jednom od analiziranih uzoraka. Inaktivacija TP53 gena detektovana je kod 56,7% uzoraka i utvrđeno je da statistički značajno korelira sa gradusom 2 i statusom 2 OSCC. Pored ovoga, utvrđeno je da statistički značajan broj uzoraka gradusa 2, sa aktiviranim TP53 genom ima istovremeno aktiviran i c-myc onkogen. Zaključak: TP53, najčešće mutirani gen u oralnim karcinomima, ostaje za sada i najpouzdaniji marker progresije kod OSCC. Obzirom na detektovani sinergizam između TP53 i c-myc gena, možemo reći da su istovremene promene u ova dva gena još pouzdaniji pokazatelj progresije OSSC iz gradusa 1 u gradus 2.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "TP53 and c-myc Co-alterations: A hallmark of oral cancer progression, Simultana alteracija TP53 i c-myc gena - obeležje progresije oralnih karcinoma",
volume = "32",
number = "4",
pages = "380-388",
doi = "10.2478/jomb-2014-0009"
}
Tanić, N., Milašin, J., Dramićanin, T., Bošković, M., Vukadinović, M., Milošević, V.,& Tanić, N.. (2013). TP53 and c-myc Co-alterations: A hallmark of oral cancer progression. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 32(4), 380-388.
https://doi.org/10.2478/jomb-2014-0009
Tanić N, Milašin J, Dramićanin T, Bošković M, Vukadinović M, Milošević V, Tanić N. TP53 and c-myc Co-alterations: A hallmark of oral cancer progression. in Journal of Medical Biochemistry. 2013;32(4):380-388.
doi:10.2478/jomb-2014-0009 .
Tanić, Nasta, Milašin, Jelena, Dramićanin, Tatjana, Bošković, Maja, Vukadinović, Miroslav, Milošević, Verica, Tanić, Nikola, "TP53 and c-myc Co-alterations: A hallmark of oral cancer progression" in Journal of Medical Biochemistry, 32, no. 4 (2013):380-388,
https://doi.org/10.2478/jomb-2014-0009 . .
4
3
3

The effects of orthognathic surgery on mandibular movements in patients with mandibular prognathism

Sinobad, Vladimir; Dodić, Slobodan; Strajnić, Ljiljana; Vukadinović, Miroslav

(Srpsko lekarsko društvo, Beograd, 2012)

TY  - JOUR
AU  - Sinobad, Vladimir
AU  - Dodić, Slobodan
AU  - Strajnić, Ljiljana
AU  - Vukadinović, Miroslav
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1706
AB  - Introduction. Mandibular prognathism, one of the most severe dentofacial deformities, affects the person’s appearance, psychological health and the quality of life in the most sensitive age period. Objective. The aim of this study was to evaluate the effects of sagittal split ramus osteotomy on the range of mandibular border movements in the early postoperative period. Methods. The study was conducted on 20 patients, of mean age 20.8 years, with mandibular prognathism. All patients included in this study were operated on by bilateral sagittal spliting ramus osteotomy according to Obwegeser and Dal Pont followed by mandibular immobilization during eight weeks. In all patients mandibular border movements were recorded before and six months after surgery using the computerized pantograph Arcus-Digma (KaVo EWL GmbH, Leutkirch, Germany). Results. The analysis of the chosen kinematic parameters revealed that sagittal split ramus osteotomy followed by eight weeks of mandibular immobilization had severe effects on the mouth opening. Six months after surgery the range of maximal mouth opening decreased for approximately 13.9 mm in relation to the preoperative stage. On the contrary, the ranges of maximal protrusion and the border of laterotrusive excursions increased significantly after surgery. Conclusion. In patients with mandibular prognathism where enormous mandibular growth was the main causal factor of the deformity, the sagittal split ramus osteotomy yielded good results. The rigid fixation of bone fragments and reduced period of mandibular immobilization followed by appropriate physical therapy could considerably contribute to a more rapid recovery of mandibular kinematics in the postoperative period.
AB  - Uvod. Mandibularni prognatizam je jedan od najtežih dentofacijalnih deformiteta koji se u punoj meri manifestuje u najosetljivijim godinama života, ugrožavajući izgled osobe, njeno psihičko zdravlje i kvalitet života. Cilj rada. Cilj rada je bio da se ispita efekat sagitalne klizajuće osteotomije ramusa mandibule na dijapazone graničnih kretnji donje vilice u ranom postoperacionom periodu. Metode rada. Istraživanje je obavljeno na dvadeset osoba s mandibularnim prognatizmom prosečnog uzrasta od 20,8 godina. Svi ispitanici su operisani bilateralnom sagitalnom klizajućom osteotomijom ramusa mandibule po Obvegezeru (Obwegeser) i Dal Pontu (Dal Pont), nakon čega je primenjena intermaksilarna imobilizacija mandibule u trajanju od osam nedelja. Granične kretnje donje vilice su zabeležene kod svih ispitanika pre i šest meseci nakon hirurške korekcije pomoću kompjuterskog pantografa Arcus-Digma (KaVo EWL GmbH, Leutkirch, Germany). Rezultati. Rezultati analize odabranih kinematskih parametara pokazuju da je hirurški zahvat udružen s intermaksilarnom imobilizacijom mandibule tokom osam nedelja imao izrazito loš uticaj na dijapazon maksimalnog otvaranja usta kod operisanih ispitanika. Šest meseci nakon operacije dijapazon maksimalnog otvaranja usta je bio u proseku za 13 mm manji u odnosu na stanje pre hirurškog lečenja. S druge strane, dijapazoni maksimalne protruzije i graničnih lateralnih pokreta su se nakon operacije znatno povećali. Zaključak. Sagitalna klizajuća osteotomija ramusa mandibule daje dobre rezultate kod osoba s mandibularnim prognatizmom kod kojih je enorman rast donje vilice glavni uzročnik deformiteta. Rigidna fiksacija koštanih fragmenata i skraćen period intermaksilarne imobilizacije uz primenu odgovarajuće fizikalne terapije znatno bi doprineli bržoj rehabilitaciji pokreta mandibule u postoperacionom periodu.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The effects of orthognathic surgery on mandibular movements in patients with mandibular prognathism
T1  - Efekti ortognatskog hirurškog lečenja na kretnje donje vilice osoba s mandibularnim prognatizmom
VL  - 140
IS  - 11-12
SP  - 704
EP  - 710
DO  - 10.2298/SARH1212704S
ER  - 
@article{
author = "Sinobad, Vladimir and Dodić, Slobodan and Strajnić, Ljiljana and Vukadinović, Miroslav",
year = "2012",
abstract = "Introduction. Mandibular prognathism, one of the most severe dentofacial deformities, affects the person’s appearance, psychological health and the quality of life in the most sensitive age period. Objective. The aim of this study was to evaluate the effects of sagittal split ramus osteotomy on the range of mandibular border movements in the early postoperative period. Methods. The study was conducted on 20 patients, of mean age 20.8 years, with mandibular prognathism. All patients included in this study were operated on by bilateral sagittal spliting ramus osteotomy according to Obwegeser and Dal Pont followed by mandibular immobilization during eight weeks. In all patients mandibular border movements were recorded before and six months after surgery using the computerized pantograph Arcus-Digma (KaVo EWL GmbH, Leutkirch, Germany). Results. The analysis of the chosen kinematic parameters revealed that sagittal split ramus osteotomy followed by eight weeks of mandibular immobilization had severe effects on the mouth opening. Six months after surgery the range of maximal mouth opening decreased for approximately 13.9 mm in relation to the preoperative stage. On the contrary, the ranges of maximal protrusion and the border of laterotrusive excursions increased significantly after surgery. Conclusion. In patients with mandibular prognathism where enormous mandibular growth was the main causal factor of the deformity, the sagittal split ramus osteotomy yielded good results. The rigid fixation of bone fragments and reduced period of mandibular immobilization followed by appropriate physical therapy could considerably contribute to a more rapid recovery of mandibular kinematics in the postoperative period., Uvod. Mandibularni prognatizam je jedan od najtežih dentofacijalnih deformiteta koji se u punoj meri manifestuje u najosetljivijim godinama života, ugrožavajući izgled osobe, njeno psihičko zdravlje i kvalitet života. Cilj rada. Cilj rada je bio da se ispita efekat sagitalne klizajuće osteotomije ramusa mandibule na dijapazone graničnih kretnji donje vilice u ranom postoperacionom periodu. Metode rada. Istraživanje je obavljeno na dvadeset osoba s mandibularnim prognatizmom prosečnog uzrasta od 20,8 godina. Svi ispitanici su operisani bilateralnom sagitalnom klizajućom osteotomijom ramusa mandibule po Obvegezeru (Obwegeser) i Dal Pontu (Dal Pont), nakon čega je primenjena intermaksilarna imobilizacija mandibule u trajanju od osam nedelja. Granične kretnje donje vilice su zabeležene kod svih ispitanika pre i šest meseci nakon hirurške korekcije pomoću kompjuterskog pantografa Arcus-Digma (KaVo EWL GmbH, Leutkirch, Germany). Rezultati. Rezultati analize odabranih kinematskih parametara pokazuju da je hirurški zahvat udružen s intermaksilarnom imobilizacijom mandibule tokom osam nedelja imao izrazito loš uticaj na dijapazon maksimalnog otvaranja usta kod operisanih ispitanika. Šest meseci nakon operacije dijapazon maksimalnog otvaranja usta je bio u proseku za 13 mm manji u odnosu na stanje pre hirurškog lečenja. S druge strane, dijapazoni maksimalne protruzije i graničnih lateralnih pokreta su se nakon operacije znatno povećali. Zaključak. Sagitalna klizajuća osteotomija ramusa mandibule daje dobre rezultate kod osoba s mandibularnim prognatizmom kod kojih je enorman rast donje vilice glavni uzročnik deformiteta. Rigidna fiksacija koštanih fragmenata i skraćen period intermaksilarne imobilizacije uz primenu odgovarajuće fizikalne terapije znatno bi doprineli bržoj rehabilitaciji pokreta mandibule u postoperacionom periodu.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The effects of orthognathic surgery on mandibular movements in patients with mandibular prognathism, Efekti ortognatskog hirurškog lečenja na kretnje donje vilice osoba s mandibularnim prognatizmom",
volume = "140",
number = "11-12",
pages = "704-710",
doi = "10.2298/SARH1212704S"
}
Sinobad, V., Dodić, S., Strajnić, L.,& Vukadinović, M.. (2012). The effects of orthognathic surgery on mandibular movements in patients with mandibular prognathism. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 140(11-12), 704-710.
https://doi.org/10.2298/SARH1212704S
Sinobad V, Dodić S, Strajnić L, Vukadinović M. The effects of orthognathic surgery on mandibular movements in patients with mandibular prognathism. in Srpski arhiv za celokupno lekarstvo. 2012;140(11-12):704-710.
doi:10.2298/SARH1212704S .
Sinobad, Vladimir, Dodić, Slobodan, Strajnić, Ljiljana, Vukadinović, Miroslav, "The effects of orthognathic surgery on mandibular movements in patients with mandibular prognathism" in Srpski arhiv za celokupno lekarstvo, 140, no. 11-12 (2012):704-710,
https://doi.org/10.2298/SARH1212704S . .
1
1
1

Analysis of sagittal condyl inclination in subjects with temporomandibular disorders

Dodić, Slobodan; Sinobad, Vladimir; Vukadinović, Miroslav

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2010)

TY  - JOUR
AU  - Dodić, Slobodan
AU  - Sinobad, Vladimir
AU  - Vukadinović, Miroslav
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1538
AB  - Bacground/Aim. Disturbances of mandibular border movements is considered to be one of the major signs of temporomandibular disorders (TMD). The purpose of this study was to evaluate the possible association between disturbances of mandibular border movements and the presence of symptoms of TMD in the young. Methods. This study included two groups of volunteers between 18 and 26 years of age. The study group included 30 examiners with signs (symptoms) of TMD, and the control group also included 30 persons without any signs (symptoms) of TMD. The presence of TMD was confirmed according to the craniomandibular index (Helkimo). The functional analysis of mandibular movements was performed in each subject using the computer pantograph. Results. The results of this study did not confirm any significant differences between the values of the condylar variables/sagittal condylar inclination, length of the sagital condylar guidance, in the control and in the study group. Conclusion. The study did not confirm significant differences in the length and inclination of the protrusive condylar guidance, as well as in the values of the sagital condylar inclination between the subjects with the signs and symptoms of TMD and the normal asymptomatic subjects.
AB  - Uvod/Cilj. Poremećena pokretljivost donje vilice jedan je od osnovnih znakova temporomandibularnih disfunkcija (TMD). Cilj ovog istraživanja bio je da se utvrdi eventualna veza između poremećene pokretljivosti donje vilice i prisutnih simptoma TMD kod mladih. Metode. Ovo istraživanje obuhvatilo je dve grupe ispitanika starosti od 18 do 25 godina. Studijsku grupu činilo je 30 ispitanika sa znacima i simptomima TMD, dok je kontrolnu grupu činilo 30 ispitanika bez znakova i simptoma TMD. Prisustvo TMD potvrđeno je uz pomoć kraniomandibularnog indeksa (Helkimo). Funkcionalna analiza kretnji donje vilice urađena je uz pomoć kompjuterskog pantografa. Rezultati. Našim ispitivanjem nije ustanovljena značajna razlika u vrednosti nagiba i dužine sagitalne kondilne putanje, između ispitanika kontrolne i studijske grupe. Zaključak. U ovom istraživanju nisu utvrđene statistički značajne razlike u dužini i inklinaciji protruzione putanje kondila, kao i vrednosti sagitalne kondilne putanje između ispitanika kod kojih postoje znaci i simptomi TMD i ispitanika bez znakova i simptoma TMD.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Analysis of sagittal condyl inclination in subjects with temporomandibular disorders
T1  - Analiza sagitalne kondilne putanje kod ispitanika sa temporomandibularnim disfunkcijama
VL  - 67
IS  - 5
SP  - 391
EP  - 396
DO  - 10.2298/VSP1005391D
ER  - 
@article{
author = "Dodić, Slobodan and Sinobad, Vladimir and Vukadinović, Miroslav",
year = "2010",
abstract = "Bacground/Aim. Disturbances of mandibular border movements is considered to be one of the major signs of temporomandibular disorders (TMD). The purpose of this study was to evaluate the possible association between disturbances of mandibular border movements and the presence of symptoms of TMD in the young. Methods. This study included two groups of volunteers between 18 and 26 years of age. The study group included 30 examiners with signs (symptoms) of TMD, and the control group also included 30 persons without any signs (symptoms) of TMD. The presence of TMD was confirmed according to the craniomandibular index (Helkimo). The functional analysis of mandibular movements was performed in each subject using the computer pantograph. Results. The results of this study did not confirm any significant differences between the values of the condylar variables/sagittal condylar inclination, length of the sagital condylar guidance, in the control and in the study group. Conclusion. The study did not confirm significant differences in the length and inclination of the protrusive condylar guidance, as well as in the values of the sagital condylar inclination between the subjects with the signs and symptoms of TMD and the normal asymptomatic subjects., Uvod/Cilj. Poremećena pokretljivost donje vilice jedan je od osnovnih znakova temporomandibularnih disfunkcija (TMD). Cilj ovog istraživanja bio je da se utvrdi eventualna veza između poremećene pokretljivosti donje vilice i prisutnih simptoma TMD kod mladih. Metode. Ovo istraživanje obuhvatilo je dve grupe ispitanika starosti od 18 do 25 godina. Studijsku grupu činilo je 30 ispitanika sa znacima i simptomima TMD, dok je kontrolnu grupu činilo 30 ispitanika bez znakova i simptoma TMD. Prisustvo TMD potvrđeno je uz pomoć kraniomandibularnog indeksa (Helkimo). Funkcionalna analiza kretnji donje vilice urađena je uz pomoć kompjuterskog pantografa. Rezultati. Našim ispitivanjem nije ustanovljena značajna razlika u vrednosti nagiba i dužine sagitalne kondilne putanje, između ispitanika kontrolne i studijske grupe. Zaključak. U ovom istraživanju nisu utvrđene statistički značajne razlike u dužini i inklinaciji protruzione putanje kondila, kao i vrednosti sagitalne kondilne putanje između ispitanika kod kojih postoje znaci i simptomi TMD i ispitanika bez znakova i simptoma TMD.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Analysis of sagittal condyl inclination in subjects with temporomandibular disorders, Analiza sagitalne kondilne putanje kod ispitanika sa temporomandibularnim disfunkcijama",
volume = "67",
number = "5",
pages = "391-396",
doi = "10.2298/VSP1005391D"
}
Dodić, S., Sinobad, V.,& Vukadinović, M.. (2010). Analysis of sagittal condyl inclination in subjects with temporomandibular disorders. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 67(5), 391-396.
https://doi.org/10.2298/VSP1005391D
Dodić S, Sinobad V, Vukadinović M. Analysis of sagittal condyl inclination in subjects with temporomandibular disorders. in Vojnosanitetski pregled. 2010;67(5):391-396.
doi:10.2298/VSP1005391D .
Dodić, Slobodan, Sinobad, Vladimir, Vukadinović, Miroslav, "Analysis of sagittal condyl inclination in subjects with temporomandibular disorders" in Vojnosanitetski pregled, 67, no. 5 (2010):391-396,
https://doi.org/10.2298/VSP1005391D . .
2
2

Genomic instability and tumor-specific DNA alterations in oral leukoplakias

Tanić, Nasta; Tanić, Nikola; Milašin, Jelena; Vukadinović, Miroslav; Dimitrijević, Bogomir

(Wiley, Hoboken, 2009)

TY  - JOUR
AU  - Tanić, Nasta
AU  - Tanić, Nikola
AU  - Milašin, Jelena
AU  - Vukadinović, Miroslav
AU  - Dimitrijević, Bogomir
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1483
AB  - Leukoplakias, clinically identifiable premalignant lesions, often precede oral squamous cell carcinoma (OSCC). Identification of leukoplakias that have the potential for transformation to malignancy is a key clinical problem. The aim of this study was to assess genomic instability, and to detect tumor-specific genomic alterations, in leukoplakias. Genomic instability was analyzed by comparing the DNA fingerprints of 32 leukoplakias with those of paired normal tissue. In addition, the mutational status of the p53 gene was analyzed using polymerase chain reaction-single-stranded conformational polymorphism (PCR-SSCP) and polymerase chain reaction-heteroduplex DNA (PCR-HET), and the mutations were subsequently confirmed by DNA sequencing. Moderate-to-significant genomic instability was detected in all leukoplakias analysed. Nine unique amplicons, present in leukoplakias but not in normal tissue, were retrieved and successfully characterized. The p53 gene was mutated in 40.6% of patients. Four patients with moderate instability and mutated p53 developed OSCC. The data obtained in this study support and concretize the thesis that premalignant lesions possess many of the alterations found in cancer before the development of a malignant phenotype. Inactivation or mutation of the p53 tumor-suppressor might be an early event contributing to genomic instability and increasing the risk of malignant transformation.
PB  - Wiley, Hoboken
T2  - European Journal of Oral Sciences
T1  - Genomic instability and tumor-specific DNA alterations in oral leukoplakias
VL  - 117
IS  - 3
SP  - 231
EP  - 237
DO  - 10.1111/j.1600-0722.2009.00624.x
ER  - 
@article{
author = "Tanić, Nasta and Tanić, Nikola and Milašin, Jelena and Vukadinović, Miroslav and Dimitrijević, Bogomir",
year = "2009",
abstract = "Leukoplakias, clinically identifiable premalignant lesions, often precede oral squamous cell carcinoma (OSCC). Identification of leukoplakias that have the potential for transformation to malignancy is a key clinical problem. The aim of this study was to assess genomic instability, and to detect tumor-specific genomic alterations, in leukoplakias. Genomic instability was analyzed by comparing the DNA fingerprints of 32 leukoplakias with those of paired normal tissue. In addition, the mutational status of the p53 gene was analyzed using polymerase chain reaction-single-stranded conformational polymorphism (PCR-SSCP) and polymerase chain reaction-heteroduplex DNA (PCR-HET), and the mutations were subsequently confirmed by DNA sequencing. Moderate-to-significant genomic instability was detected in all leukoplakias analysed. Nine unique amplicons, present in leukoplakias but not in normal tissue, were retrieved and successfully characterized. The p53 gene was mutated in 40.6% of patients. Four patients with moderate instability and mutated p53 developed OSCC. The data obtained in this study support and concretize the thesis that premalignant lesions possess many of the alterations found in cancer before the development of a malignant phenotype. Inactivation or mutation of the p53 tumor-suppressor might be an early event contributing to genomic instability and increasing the risk of malignant transformation.",
publisher = "Wiley, Hoboken",
journal = "European Journal of Oral Sciences",
title = "Genomic instability and tumor-specific DNA alterations in oral leukoplakias",
volume = "117",
number = "3",
pages = "231-237",
doi = "10.1111/j.1600-0722.2009.00624.x"
}
Tanić, N., Tanić, N., Milašin, J., Vukadinović, M.,& Dimitrijević, B.. (2009). Genomic instability and tumor-specific DNA alterations in oral leukoplakias. in European Journal of Oral Sciences
Wiley, Hoboken., 117(3), 231-237.
https://doi.org/10.1111/j.1600-0722.2009.00624.x
Tanić N, Tanić N, Milašin J, Vukadinović M, Dimitrijević B. Genomic instability and tumor-specific DNA alterations in oral leukoplakias. in European Journal of Oral Sciences. 2009;117(3):231-237.
doi:10.1111/j.1600-0722.2009.00624.x .
Tanić, Nasta, Tanić, Nikola, Milašin, Jelena, Vukadinović, Miroslav, Dimitrijević, Bogomir, "Genomic instability and tumor-specific DNA alterations in oral leukoplakias" in European Journal of Oral Sciences, 117, no. 3 (2009):231-237,
https://doi.org/10.1111/j.1600-0722.2009.00624.x . .
8
6
8

Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients

Vukadinović, Miroslav; Jezdić, Zoran; Petrović, Milan; Medenica, Ljiljana M.; Lens, Marko

(W B Saunders Co-Elsevier Inc, Philadelphia, 2007)

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Petrović, Milan
AU  - Medenica, Ljiljana M.
AU  - Lens, Marko
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1347
AB  - Background: The most common type of lip carcinoma is squamous cell carcinoma (SCC), accounting for approximately 90% of all oral malignancies. Currently, surgery and/or radiotherapy are considered the standards of care for SCC of the lip. Materials and Methods: We retrospectively analyzed medical records of patients diagnosed with SCC of the lip at the Clinic for Maxillofacial surgery at University of Belgrade (Belgrade, Serbia) during a period between 1991 and 2000. Results: A total of 223 patients with SCC of the lip were diagnosed and treated during a 10-year period. The overall male-to-female ratio was 5 to 0. The most frequently affected site was the lower lip (92.8%,). Mean diameter of the tumor was 30.1 mm (range, 5 to 80 full Neck lymph node metastases at presentation was detected in 26.5% of patients, who subsequently underwent neck dissection. We observed a linear trend in the association between the size of the tumor and the clinical stage of the neck (chi(2) = 15.1; df = 1; P  lt  .0001). Different surgical techniques were used for reconstruction of the lip defect after tumor removal. After a median follow-up of 56 months (range, 15 to 78 months), local recurrence occurred in 10.8% of patients while regional metastases developed in 4.5% of patients. Mortality from SCC of the lip was only 2.2%. Conclusion: SCC of the lip generally has a favorable outcome. Recently, there have been no major advances in lip reconstruction but rather continued improvement on accepted techniques. Early detection is essential for the successful treatment of SCC of the lip, which requires a multidisciplinary approach.
PB  - W B Saunders Co-Elsevier Inc, Philadelphia
T2  - Journal of Oral & Maxillofacial Surgery
T1  - Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients
VL  - 65
IS  - 4
SP  - 675
EP  - 679
DO  - 10.1016/j.joms.2006.03.054
ER  - 
@article{
author = "Vukadinović, Miroslav and Jezdić, Zoran and Petrović, Milan and Medenica, Ljiljana M. and Lens, Marko",
year = "2007",
abstract = "Background: The most common type of lip carcinoma is squamous cell carcinoma (SCC), accounting for approximately 90% of all oral malignancies. Currently, surgery and/or radiotherapy are considered the standards of care for SCC of the lip. Materials and Methods: We retrospectively analyzed medical records of patients diagnosed with SCC of the lip at the Clinic for Maxillofacial surgery at University of Belgrade (Belgrade, Serbia) during a period between 1991 and 2000. Results: A total of 223 patients with SCC of the lip were diagnosed and treated during a 10-year period. The overall male-to-female ratio was 5 to 0. The most frequently affected site was the lower lip (92.8%,). Mean diameter of the tumor was 30.1 mm (range, 5 to 80 full Neck lymph node metastases at presentation was detected in 26.5% of patients, who subsequently underwent neck dissection. We observed a linear trend in the association between the size of the tumor and the clinical stage of the neck (chi(2) = 15.1; df = 1; P  lt  .0001). Different surgical techniques were used for reconstruction of the lip defect after tumor removal. After a median follow-up of 56 months (range, 15 to 78 months), local recurrence occurred in 10.8% of patients while regional metastases developed in 4.5% of patients. Mortality from SCC of the lip was only 2.2%. Conclusion: SCC of the lip generally has a favorable outcome. Recently, there have been no major advances in lip reconstruction but rather continued improvement on accepted techniques. Early detection is essential for the successful treatment of SCC of the lip, which requires a multidisciplinary approach.",
publisher = "W B Saunders Co-Elsevier Inc, Philadelphia",
journal = "Journal of Oral & Maxillofacial Surgery",
title = "Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients",
volume = "65",
number = "4",
pages = "675-679",
doi = "10.1016/j.joms.2006.03.054"
}
Vukadinović, M., Jezdić, Z., Petrović, M., Medenica, L. M.,& Lens, M.. (2007). Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients. in Journal of Oral & Maxillofacial Surgery
W B Saunders Co-Elsevier Inc, Philadelphia., 65(4), 675-679.
https://doi.org/10.1016/j.joms.2006.03.054
Vukadinović M, Jezdić Z, Petrović M, Medenica LM, Lens M. Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients. in Journal of Oral & Maxillofacial Surgery. 2007;65(4):675-679.
doi:10.1016/j.joms.2006.03.054 .
Vukadinović, Miroslav, Jezdić, Zoran, Petrović, Milan, Medenica, Ljiljana M., Lens, Marko, "Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients" in Journal of Oral & Maxillofacial Surgery, 65, no. 4 (2007):675-679,
https://doi.org/10.1016/j.joms.2006.03.054 . .
71
52
69

Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries

Pucar, Ana; Milašin, Jelena; Leković, Vojislav; Vukadinović, Miroslav; Ristić, Miljko; Putnik, Svetozar; Kenney, Barrie

(Wiley, Hoboken, 2007)

TY  - JOUR
AU  - Pucar, Ana
AU  - Milašin, Jelena
AU  - Leković, Vojislav
AU  - Vukadinović, Miroslav
AU  - Ristić, Miljko
AU  - Putnik, Svetozar
AU  - Kenney, Barrie
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1349
AB  - Chronic infections, such as periodontitis, have been associated with an increase for atherosclerosis and coronary artery disease. The aim of this study was to investigate biopsy samples of coronary and internal mammary arteries for the presence of putative pathogenic bacteria (Porphyromanas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia, and Tannerella forsythensis), Chlamydia pneumoniae, and human cytomegalovirus (CMV). Methods: Patients with a diagnosis of coronary artery disease were included in the study. fifteen coronary arteries with atherosclerosis and 15 internal mammary arteries without clinically assessable atherosclerotic degeneration were investigated. Both groups of specimens were obtained during coronary artery bypass grafting surgery. In all cases, the coronary and mammary artery specimens were taken from the same patient. The detection of periodontal pathogens, C. pneumoniae, and CMV was done by polymerase chain reaction analysis. Results: Bacterial DNA was found in nine of 15 (60%) coronary artery biopsy samples: P. gingivalis in eight (53.33%), A. actinomycetemcomitans in four (26.67%), P. intermedia in five (33.33%), and T. forsythensis in two (13.33%) samples; CMV was detected in 10 (66.67%) samples, and c. pneumoniae was detected in five (33.33%) samples. Some of the samples contained more than one type of bacteria. Periodontal pathogens were not detected in internal mammary artery biopsies, whereas CMV was present in seven (46.67%) samples and C. pneumoniae was present in six (40%) samples. Conclusion: The absence of putative pathogenic bacteria in internal mammary arteries, which are known to be affected rarely by atherosclerotic changes, and their presence in a high percentage of atherosclerotic coronary arteries support the concept that periodontal organisms are associated with the development and progression of atherosclerosis.
PB  - Wiley, Hoboken
T2  - Journal of Periodontology
T1  - Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries
VL  - 78
IS  - 4
SP  - 677
EP  - 682
DO  - 10.1902/jop.2007.060062
ER  - 
@article{
author = "Pucar, Ana and Milašin, Jelena and Leković, Vojislav and Vukadinović, Miroslav and Ristić, Miljko and Putnik, Svetozar and Kenney, Barrie",
year = "2007",
abstract = "Chronic infections, such as periodontitis, have been associated with an increase for atherosclerosis and coronary artery disease. The aim of this study was to investigate biopsy samples of coronary and internal mammary arteries for the presence of putative pathogenic bacteria (Porphyromanas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia, and Tannerella forsythensis), Chlamydia pneumoniae, and human cytomegalovirus (CMV). Methods: Patients with a diagnosis of coronary artery disease were included in the study. fifteen coronary arteries with atherosclerosis and 15 internal mammary arteries without clinically assessable atherosclerotic degeneration were investigated. Both groups of specimens were obtained during coronary artery bypass grafting surgery. In all cases, the coronary and mammary artery specimens were taken from the same patient. The detection of periodontal pathogens, C. pneumoniae, and CMV was done by polymerase chain reaction analysis. Results: Bacterial DNA was found in nine of 15 (60%) coronary artery biopsy samples: P. gingivalis in eight (53.33%), A. actinomycetemcomitans in four (26.67%), P. intermedia in five (33.33%), and T. forsythensis in two (13.33%) samples; CMV was detected in 10 (66.67%) samples, and c. pneumoniae was detected in five (33.33%) samples. Some of the samples contained more than one type of bacteria. Periodontal pathogens were not detected in internal mammary artery biopsies, whereas CMV was present in seven (46.67%) samples and C. pneumoniae was present in six (40%) samples. Conclusion: The absence of putative pathogenic bacteria in internal mammary arteries, which are known to be affected rarely by atherosclerotic changes, and their presence in a high percentage of atherosclerotic coronary arteries support the concept that periodontal organisms are associated with the development and progression of atherosclerosis.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontology",
title = "Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries",
volume = "78",
number = "4",
pages = "677-682",
doi = "10.1902/jop.2007.060062"
}
Pucar, A., Milašin, J., Leković, V., Vukadinović, M., Ristić, M., Putnik, S.,& Kenney, B.. (2007). Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries. in Journal of Periodontology
Wiley, Hoboken., 78(4), 677-682.
https://doi.org/10.1902/jop.2007.060062
Pucar A, Milašin J, Leković V, Vukadinović M, Ristić M, Putnik S, Kenney B. Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries. in Journal of Periodontology. 2007;78(4):677-682.
doi:10.1902/jop.2007.060062 .
Pucar, Ana, Milašin, Jelena, Leković, Vojislav, Vukadinović, Miroslav, Ristić, Miljko, Putnik, Svetozar, Kenney, Barrie, "Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries" in Journal of Periodontology, 78, no. 4 (2007):677-682,
https://doi.org/10.1902/jop.2007.060062 . .
3
121
91
121

Roentgencraniometric analysis of the angular craniofacial dimensions in subjects with temporomandibular disorders

Dodić, Slobodan; Vukadinović, Miroslav; Sinobad, Vladimir

(Srpsko lekarsko društvo, Beograd, 2007)

TY  - JOUR
AU  - Dodić, Slobodan
AU  - Vukadinović, Miroslav
AU  - Sinobad, Vladimir
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1348
AB  - Introduction: Anomalies in growth and development of the craniofacial skeleton, particularly of vertical dysplasia, may be accompanied by distinct signs and symptoms of temporomandibular disorders. Vertical dysplasia followed by numerous occlusal disturbances alters muscular activity resulting in non-physiological strain on articular structures and their remodelling. Objective. The purpose of this study was to evaluate a possible assocciation between certain morphologic features of the craniofacial skeleton and the presence of signs and symptoms of temporomandibular disorders in young adults with preserved natural dentition. Method. The investigation was carried out on 30 lateral cephalometric radiographs made of 30 subjects with signs and symptoms of temporomandibular disorders. According to the values of the ANB angle (Steiner cephalometric analysis), all subjects were classified in the skeletal class 1.The control group consisted of 50 lateral cephalometric radiographs made of subjects with the skeletal class 1 without signs and symptoms of temporomandibular disorders. The roentgencraniometric analysis of lateral cephalometric radiographs included the evaluation of 20 angular dimensions. Results. The result of this study points at significant differences between the Bolton standards and the following angular dimensions in subjects with temoromandibular disorders:(S-Na)-Pg, (B-Na)-Pg, (Pns-Ans)-(Go-Gn), Occl-i, (S-Na)-i, (S-Na)-(Go-Me), (Go-Me)-i, SNB. The comparative analysis between the subjects of the experimental and the control group revealed significant differences in the values of the following angular dimensions: OccP-(Go-Po) i (S-N)-(Go-Me) at the level of p lt 0.001. Conclusion. The values of the analyzed angular dimensions in both subjects of the experimental and the control group show significant differences when related to the same angular dimensions in the Bolton standards. This can be explained by specific morphologic features of the craniofacial skeleton in subjects of our population. Small number of significant differences in the values of the examined angular variables between the subjects with signs and symptoms of temporomandibular disorders and subjects without such signs/symptoms can be explained by the fact that the study included young persons with the skeletal class 1 jaw relationships and relatively harmonious relations within the orofacial complex.
AB  - Uvod: Anomalije u rastu i razvoju kraniofacijalnog skeleta, posebno vertikalne displazije, kao što su skeletno otvoren zagrižaj (sindrom dugog lica), dubok zagrižaj (sindrom kratkog lica) i jednostrano otvoren zagrižaj, mogu biti praćene i određenim znacima, odnosno simptomima temporomandibulnih poremećaja. Smatra se da vertikalne displazije praćene brojnim okluzivnim smetnjama menjaju aktivnost mišića, dovodeći do nefiziološkog opterećenja zglobnih struktura i njihove remodelacije. Cilj rada. Cilj istraživanja je bio da se utvrdi eventualna veza između određenih morfoloških odlika kraniofacijalnog skeleta i znakova i simptoma temporomandibulnih poremećaja kod mladih osoba s očuvanom prirodnom okluzijom. Metod rada. Za potrebe istraživanja načinjeno je 30 profilnih telerendgenograma glave 30 ispitanika sa znacima i simptomima temporomandibulnih poremećaja. Vrednovanjem ugla ANB (kefalometrijska analiza po Štajneru) iz ove serije izabrano je 20 snimaka ispitanika sa znacima, odnosno simptomima temporomandibulnih poremećaja čiji skeletni odnosi odgovaraju prvoj klasi. Kontrolnu grupu za rendgenkraniometrijska istraživanja činilo je 50 profilnih telerendgenograma glave osoba koji pripadaju prvoj skeletnoj klasi i kod kojih nisu utvrđeni znaci i simptomi temporomandibulnih poremećaja. Rendgenkraniometrijska analiza obavljena na svakom profilnom telerendgenogramu obuhvatila je vrednovanje 20 angularnih dimenzija. Rezultati. Rezultati studije su pokazali da postoji statistički značajna razlika između ispitanika sa temporomandibulnim poremećajima i vrednosti sledećih angularnih dimenzija u Boltonovim standardima: (S-Na)-Pg, (B-Na)-Pg, (Pns-Ans)- (Go-Gn), Occl-i, (S-Na)-i, (S-Na)-(Go-Me), (Go-Me)-i, SNB. Komparativnom analizom su utvrđene statistički značajne razlike između eksperimentalne i kontrolne grupe u vrednostima angularnih dimenzija OccP-(Go-Po) i (S-N)-(Go-Me) na nivou verovatnoće od p lt 0,001. Zaključak. Analizirane angularne dimenzije kod ispitanika i eksperimentalne i kontrolne grupe značajno se razlikuju od istih angularnih dimenzija u Boltonovim standardima, što se može objasniti specifičnim morfološkim obeležjima kraniofacijalnog skeleta kod naše populacije. Mali broj značajnih razlika u ispitivanim angularnim dimenzijama između ispitanika sa znacima i simptomima temporomandibulnih poremećaja i i ispitanika bez takvih znakova i simptoma objašnjava se činjenicom da su ispitivanja obavljena na ciljnim grupama mladih ispitanika prve skeletne klase i relativno harmoničnim odnosima u predelu orofacijalnog kompleksa.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Roentgencraniometric analysis of the angular craniofacial dimensions in subjects with temporomandibular disorders
T1  - Rendgenkraniometrijska analiza angularnih kraniofacijalnih dimenzija kod osoba sa temporomandibulnim disfunkcijama
VL  - 135
IS  - 5-6
SP  - 269
EP  - 274
DO  - 10.2298/SARH0706269D
ER  - 
@article{
author = "Dodić, Slobodan and Vukadinović, Miroslav and Sinobad, Vladimir",
year = "2007",
abstract = "Introduction: Anomalies in growth and development of the craniofacial skeleton, particularly of vertical dysplasia, may be accompanied by distinct signs and symptoms of temporomandibular disorders. Vertical dysplasia followed by numerous occlusal disturbances alters muscular activity resulting in non-physiological strain on articular structures and their remodelling. Objective. The purpose of this study was to evaluate a possible assocciation between certain morphologic features of the craniofacial skeleton and the presence of signs and symptoms of temporomandibular disorders in young adults with preserved natural dentition. Method. The investigation was carried out on 30 lateral cephalometric radiographs made of 30 subjects with signs and symptoms of temporomandibular disorders. According to the values of the ANB angle (Steiner cephalometric analysis), all subjects were classified in the skeletal class 1.The control group consisted of 50 lateral cephalometric radiographs made of subjects with the skeletal class 1 without signs and symptoms of temporomandibular disorders. The roentgencraniometric analysis of lateral cephalometric radiographs included the evaluation of 20 angular dimensions. Results. The result of this study points at significant differences between the Bolton standards and the following angular dimensions in subjects with temoromandibular disorders:(S-Na)-Pg, (B-Na)-Pg, (Pns-Ans)-(Go-Gn), Occl-i, (S-Na)-i, (S-Na)-(Go-Me), (Go-Me)-i, SNB. The comparative analysis between the subjects of the experimental and the control group revealed significant differences in the values of the following angular dimensions: OccP-(Go-Po) i (S-N)-(Go-Me) at the level of p lt 0.001. Conclusion. The values of the analyzed angular dimensions in both subjects of the experimental and the control group show significant differences when related to the same angular dimensions in the Bolton standards. This can be explained by specific morphologic features of the craniofacial skeleton in subjects of our population. Small number of significant differences in the values of the examined angular variables between the subjects with signs and symptoms of temporomandibular disorders and subjects without such signs/symptoms can be explained by the fact that the study included young persons with the skeletal class 1 jaw relationships and relatively harmonious relations within the orofacial complex., Uvod: Anomalije u rastu i razvoju kraniofacijalnog skeleta, posebno vertikalne displazije, kao što su skeletno otvoren zagrižaj (sindrom dugog lica), dubok zagrižaj (sindrom kratkog lica) i jednostrano otvoren zagrižaj, mogu biti praćene i određenim znacima, odnosno simptomima temporomandibulnih poremećaja. Smatra se da vertikalne displazije praćene brojnim okluzivnim smetnjama menjaju aktivnost mišića, dovodeći do nefiziološkog opterećenja zglobnih struktura i njihove remodelacije. Cilj rada. Cilj istraživanja je bio da se utvrdi eventualna veza između određenih morfoloških odlika kraniofacijalnog skeleta i znakova i simptoma temporomandibulnih poremećaja kod mladih osoba s očuvanom prirodnom okluzijom. Metod rada. Za potrebe istraživanja načinjeno je 30 profilnih telerendgenograma glave 30 ispitanika sa znacima i simptomima temporomandibulnih poremećaja. Vrednovanjem ugla ANB (kefalometrijska analiza po Štajneru) iz ove serije izabrano je 20 snimaka ispitanika sa znacima, odnosno simptomima temporomandibulnih poremećaja čiji skeletni odnosi odgovaraju prvoj klasi. Kontrolnu grupu za rendgenkraniometrijska istraživanja činilo je 50 profilnih telerendgenograma glave osoba koji pripadaju prvoj skeletnoj klasi i kod kojih nisu utvrđeni znaci i simptomi temporomandibulnih poremećaja. Rendgenkraniometrijska analiza obavljena na svakom profilnom telerendgenogramu obuhvatila je vrednovanje 20 angularnih dimenzija. Rezultati. Rezultati studije su pokazali da postoji statistički značajna razlika između ispitanika sa temporomandibulnim poremećajima i vrednosti sledećih angularnih dimenzija u Boltonovim standardima: (S-Na)-Pg, (B-Na)-Pg, (Pns-Ans)- (Go-Gn), Occl-i, (S-Na)-i, (S-Na)-(Go-Me), (Go-Me)-i, SNB. Komparativnom analizom su utvrđene statistički značajne razlike između eksperimentalne i kontrolne grupe u vrednostima angularnih dimenzija OccP-(Go-Po) i (S-N)-(Go-Me) na nivou verovatnoće od p lt 0,001. Zaključak. Analizirane angularne dimenzije kod ispitanika i eksperimentalne i kontrolne grupe značajno se razlikuju od istih angularnih dimenzija u Boltonovim standardima, što se može objasniti specifičnim morfološkim obeležjima kraniofacijalnog skeleta kod naše populacije. Mali broj značajnih razlika u ispitivanim angularnim dimenzijama između ispitanika sa znacima i simptomima temporomandibulnih poremećaja i i ispitanika bez takvih znakova i simptoma objašnjava se činjenicom da su ispitivanja obavljena na ciljnim grupama mladih ispitanika prve skeletne klase i relativno harmoničnim odnosima u predelu orofacijalnog kompleksa.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Roentgencraniometric analysis of the angular craniofacial dimensions in subjects with temporomandibular disorders, Rendgenkraniometrijska analiza angularnih kraniofacijalnih dimenzija kod osoba sa temporomandibulnim disfunkcijama",
volume = "135",
number = "5-6",
pages = "269-274",
doi = "10.2298/SARH0706269D"
}
Dodić, S., Vukadinović, M.,& Sinobad, V.. (2007). Roentgencraniometric analysis of the angular craniofacial dimensions in subjects with temporomandibular disorders. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 135(5-6), 269-274.
https://doi.org/10.2298/SARH0706269D
Dodić S, Vukadinović M, Sinobad V. Roentgencraniometric analysis of the angular craniofacial dimensions in subjects with temporomandibular disorders. in Srpski arhiv za celokupno lekarstvo. 2007;135(5-6):269-274.
doi:10.2298/SARH0706269D .
Dodić, Slobodan, Vukadinović, Miroslav, Sinobad, Vladimir, "Roentgencraniometric analysis of the angular craniofacial dimensions in subjects with temporomandibular disorders" in Srpski arhiv za celokupno lekarstvo, 135, no. 5-6 (2007):269-274,
https://doi.org/10.2298/SARH0706269D . .

Bcl-2 expression in oral squamous cell carcinoma

Popović, Branka; Jekić, B.; Novaković, I.; Luković, Ljiljana; Tepavčević, Zvezdana; Jurišić, Vladimir; Vukadinović, Miroslav; Milašin, Jelena

(Wiley-Blackwell, Hoboken, 2007)

TY  - JOUR
AU  - Popović, Branka
AU  - Jekić, B.
AU  - Novaković, I.
AU  - Luković, Ljiljana
AU  - Tepavčević, Zvezdana
AU  - Jurišić, Vladimir
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1329
AB  - Apoptosis is a genetically regulated process involved in tissue size regulation, morphogenesis, and elimination of genetically damaged cells. A pallet of genes is involved in the control of apoptosis, such as bcl-2 family whose oncogenic potential has been demonstrated in oral tumorigenesis. Different members of bcl-2 family may promote or inhibit apoptosis by synthesizing anti- and proapoptotic proteins. One of antiapoptotic proteins, bcl-2, with a crucial role in apoptosis regulation was the object of our study. By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC). Analyzed tumors originated from different sites of oral cavity; 7/26 belonged to stage II, 14/26 to stage III, and 5/26 to stage IV Immunoreactivity was scored according to the percentage and intensity of positive cytoplasmic bcl-2 staining. All tumors had low percentage of positively stained bcl-2 cells, with mean values for lower/higher intensity of 8.3 +/- 2.5/34.4 +/- 7, 7.5 +/- 1.1/31.9 +/- 4.3, and 8.4 +/- 5.8/31.5 +/- 5.8 within stages II,III, and IV, respectively. Low level of bcl-2 expression in our sample seems to be associated with higher survival rate: 77% for the 5-year follow-up period. Comparing clinicopathologic and risk factors data within each and between three groups of analyzed tumors (lip-tongue P = 0.58, tongue-floor of the mouth, P = 0.21, lip-floor of the mouth, P = 0.50) there was no significant difference. However, [sic].
PB  - Wiley-Blackwell, Hoboken
T2  - Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease
T1  - Bcl-2 expression in oral squamous cell carcinoma
VL  - 1095
SP  - 19
EP  - 25
DO  - 10.1196/annals.1397.003
ER  - 
@article{
author = "Popović, Branka and Jekić, B. and Novaković, I. and Luković, Ljiljana and Tepavčević, Zvezdana and Jurišić, Vladimir and Vukadinović, Miroslav and Milašin, Jelena",
year = "2007",
abstract = "Apoptosis is a genetically regulated process involved in tissue size regulation, morphogenesis, and elimination of genetically damaged cells. A pallet of genes is involved in the control of apoptosis, such as bcl-2 family whose oncogenic potential has been demonstrated in oral tumorigenesis. Different members of bcl-2 family may promote or inhibit apoptosis by synthesizing anti- and proapoptotic proteins. One of antiapoptotic proteins, bcl-2, with a crucial role in apoptosis regulation was the object of our study. By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC). Analyzed tumors originated from different sites of oral cavity; 7/26 belonged to stage II, 14/26 to stage III, and 5/26 to stage IV Immunoreactivity was scored according to the percentage and intensity of positive cytoplasmic bcl-2 staining. All tumors had low percentage of positively stained bcl-2 cells, with mean values for lower/higher intensity of 8.3 +/- 2.5/34.4 +/- 7, 7.5 +/- 1.1/31.9 +/- 4.3, and 8.4 +/- 5.8/31.5 +/- 5.8 within stages II,III, and IV, respectively. Low level of bcl-2 expression in our sample seems to be associated with higher survival rate: 77% for the 5-year follow-up period. Comparing clinicopathologic and risk factors data within each and between three groups of analyzed tumors (lip-tongue P = 0.58, tongue-floor of the mouth, P = 0.21, lip-floor of the mouth, P = 0.50) there was no significant difference. However, [sic].",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease",
title = "Bcl-2 expression in oral squamous cell carcinoma",
volume = "1095",
pages = "19-25",
doi = "10.1196/annals.1397.003"
}
Popović, B., Jekić, B., Novaković, I., Luković, L., Tepavčević, Z., Jurišić, V., Vukadinović, M.,& Milašin, J.. (2007). Bcl-2 expression in oral squamous cell carcinoma. in Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease
Wiley-Blackwell, Hoboken., 1095, 19-25.
https://doi.org/10.1196/annals.1397.003
Popović B, Jekić B, Novaković I, Luković L, Tepavčević Z, Jurišić V, Vukadinović M, Milašin J. Bcl-2 expression in oral squamous cell carcinoma. in Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease. 2007;1095:19-25.
doi:10.1196/annals.1397.003 .
Popović, Branka, Jekić, B., Novaković, I., Luković, Ljiljana, Tepavčević, Zvezdana, Jurišić, Vladimir, Vukadinović, Miroslav, Milašin, Jelena, "Bcl-2 expression in oral squamous cell carcinoma" in Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease, 1095 (2007):19-25,
https://doi.org/10.1196/annals.1397.003 . .
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Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism

Vukadinović, Miroslav; Jezdić, Zoran; Aničić, Boban; Sinobad, Vladimir; Miković, Nikola

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2006)

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Aničić, Boban
AU  - Sinobad, Vladimir
AU  - Miković, Nikola
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1273
AB  - Background/Aim. To establish the influence of surgical corrections of mandibular prognathism upon the position of the lower and upper anterior teeth (incisors). Methods. The changes in position of the lower and upper anterior teeth (incisors) after the surgical correction of mandibular prognathism were analyzed by means of x-ray craniometry in 183 patients (female: n = 110, male: n = 73) in which the correction had been made in accordance with the principles of sagital osteotomy of the mandibular ramus. There were 4 angular and 2 linear parameters determined in the pre- and postoperative tele-xray-pictures. The changes of these parameters were tested by means of the parametric statistic tests. Results. The performed surgical procedures did not cause statistically significant changes in the angular parameters. The changes of both linear parameters were thought highly statistically significant. Conclusion. Under the influence of the performed surgical procedures no changes were found in the position of anterior teeth (incisors) in relation to SN and the mandibular plane. They were actually moved along with the medium fragment of the lower jaw and that fragment was moved linearly backwards along the occlusal plane with a practically insignificant rotation in the cranial direction.
AB  - Uvod/Cilj. Utvrditi uticaj hirurške korekcije mandibularnog prognatizma na položaj donjih i gornjih sekutića. Metode. Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma analizirane su rendgenkraniometrijski kod 183 osobe (ž = 110; m = 73) kod kojih je korekcija izvršena po principima sagitalnih osteotomija ramusa mandibule. Na preoperativnim i postoperativnim telerendgenogramima određivana su četiri angularna i dva linearna parametra. Promene tih parametara testirane su pomoću parametrijskih statističkih testova. Rezultati. Sprovedene hirurške procedure nisu izazvale statistički značajne promene angularnih parametara. Promene oba linearna parametra bile su visoko statistički značajne. Zaključak. Pod uticajem sprovedenih hirurških korektivnih procedura ne dolazi do promene položaja sekutića u odnosu na SN i mandibularnu ravan, već se oni pomeraju zajedno sa središnjim fragmentom donje vilice. Taj fragment se kreće translatorno unazad duž okluzalne ravni, sa praktično zanemarljivom rotacijom u kranijalnom pravcu.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism
T1  - Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma
VL  - 63
IS  - 5
SP  - 457
EP  - 460
DO  - 10.2298/VSP0605457V
ER  - 
@article{
author = "Vukadinović, Miroslav and Jezdić, Zoran and Aničić, Boban and Sinobad, Vladimir and Miković, Nikola",
year = "2006",
abstract = "Background/Aim. To establish the influence of surgical corrections of mandibular prognathism upon the position of the lower and upper anterior teeth (incisors). Methods. The changes in position of the lower and upper anterior teeth (incisors) after the surgical correction of mandibular prognathism were analyzed by means of x-ray craniometry in 183 patients (female: n = 110, male: n = 73) in which the correction had been made in accordance with the principles of sagital osteotomy of the mandibular ramus. There were 4 angular and 2 linear parameters determined in the pre- and postoperative tele-xray-pictures. The changes of these parameters were tested by means of the parametric statistic tests. Results. The performed surgical procedures did not cause statistically significant changes in the angular parameters. The changes of both linear parameters were thought highly statistically significant. Conclusion. Under the influence of the performed surgical procedures no changes were found in the position of anterior teeth (incisors) in relation to SN and the mandibular plane. They were actually moved along with the medium fragment of the lower jaw and that fragment was moved linearly backwards along the occlusal plane with a practically insignificant rotation in the cranial direction., Uvod/Cilj. Utvrditi uticaj hirurške korekcije mandibularnog prognatizma na položaj donjih i gornjih sekutića. Metode. Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma analizirane su rendgenkraniometrijski kod 183 osobe (ž = 110; m = 73) kod kojih je korekcija izvršena po principima sagitalnih osteotomija ramusa mandibule. Na preoperativnim i postoperativnim telerendgenogramima određivana su četiri angularna i dva linearna parametra. Promene tih parametara testirane su pomoću parametrijskih statističkih testova. Rezultati. Sprovedene hirurške procedure nisu izazvale statistički značajne promene angularnih parametara. Promene oba linearna parametra bile su visoko statistički značajne. Zaključak. Pod uticajem sprovedenih hirurških korektivnih procedura ne dolazi do promene položaja sekutića u odnosu na SN i mandibularnu ravan, već se oni pomeraju zajedno sa središnjim fragmentom donje vilice. Taj fragment se kreće translatorno unazad duž okluzalne ravni, sa praktično zanemarljivom rotacijom u kranijalnom pravcu.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism, Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma",
volume = "63",
number = "5",
pages = "457-460",
doi = "10.2298/VSP0605457V"
}
Vukadinović, M., Jezdić, Z., Aničić, B., Sinobad, V.,& Miković, N.. (2006). Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 63(5), 457-460.
https://doi.org/10.2298/VSP0605457V
Vukadinović M, Jezdić Z, Aničić B, Sinobad V, Miković N. Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism. in Vojnosanitetski pregled. 2006;63(5):457-460.
doi:10.2298/VSP0605457V .
Vukadinović, Miroslav, Jezdić, Zoran, Aničić, Boban, Sinobad, Vladimir, Miković, Nikola, "Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism" in Vojnosanitetski pregled, 63, no. 5 (2006):457-460,
https://doi.org/10.2298/VSP0605457V . .

Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor

Vukadinović, Miroslav; Petrović, Milan; Jezdić, Zoran

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2006)

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Petrović, Milan
AU  - Jezdić, Zoran
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1270
AB  - Background/aim: Lip carcinoma makes about 1/4 of all oral carcinomas. Primary treatment of the lower lip carcinoma means radical excision of the full thickness of the lower lip tissue together with the tumor. The reconstruction of the defect accomplished after the removal of the lower lip tumor is a challenge for the surgeon and requires a detailed preoperative planning, the right choice of the method for reconstruction and the knowledge of the adequate surgical techniques needed. The aim of this study was to present a ten-year clinical results and experience concerning the reconstruction of lower lip defects longer than 4 cm by means of the modified Fries method in patients treated for the lower lip carcinoma. Methods. The reconstruction of the lower lip by means of the modified Fries method was performed in 37 patients. The following parameters were analyzed: sex, age, the time elapsed from the occurrence of the first symptoms until the first consultation with the doctor, the size of tumors, the size of the postexcision defect, TNM classification, the application of side diagnostic procedures, pathohistological diagnosis of postoperative complications. The sensibility of the lower lip region was monitored, as well as the obtained esthetic effects. Results. The results classified according to the mentioned parameters were processed, analyzed and displayed in detail. Clinical experience concerning the application of this reconstruction technique was presented and analyzed. Conclusion. The modified Fries technique can successfully be applied in the reconstruction of the lower lip defects longer than 4 cm because its application leads to satisfactory functional and acceptable esthetic results.
AB  - Uvod/cilj: Karcinomi usana čine približno oko 1/4 svih karcinoma usne duplje. Primarno lečenje karcinoma donje usne podrazumeva radikalnu eksciziju pune debljine tkiva donje usne zajedno sa tumorom. Nadoknada defekta nastalog nakon uklanjanja tumora donje usne predstavlja izazov za hirurga i zahteva detaljno preoperativno planiranje, pravilan izbor načina rekonstrukcije i poznavanje odgovarajućih hirurških tehnika. Cilj rada je da se kroz desetogodišnju retrospektivnu studiju prikažu naši klinički rezultati i iskustva u nadoknadi velikih defekata donje usne modifikovanom metodom po Friesu kod bolesnika lečenih od karcinoma donje usne. Metode. Od 256 bolesnika lečenih zbog tumora donje usne u periodu od 1992. do 2001. godine, kod 37 je primenjena rekonstrukcija modifikovanom metodom po Friesu. Analizirani su sledeći parametri: pol i godine starosti bolesnika, vreme proteklo od pojave prvih simptoma do javljanja lekaru, veličina tumora, veličina postekscizionog defekta, TNM klasifikacija, primena pomoćnih dijagnostičkih procedura, patohistološka dijagnoza, postoperativne komplikacije. Beležena su opažanja bolesnika u vezi senzibiliteta predela donje usne. Procenjivani su i ostvareni estetski efekti. Rezultati. Detaljno su obrađeni, analizirani i prikazani rezultati po navedenim parametrima. Izneta su naša klinička iskustva u primeni ove tehnike rekonstrukcije. Analizirane su njene prednosti i mane. Zaključak. Modifikovana tehnika po Friesu može se uspešno primeniti u rekonstrukciji defekata donje usne većih od 4 cm do potpunog nedostatka donje usne, jer se njenom primenom ostvaruju zadovoljavajući funkcionalni i prihvatljivi estetski rezultati.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor
T1  - Primena modifikovane metode po Friesu u rekonstrukciji donje usne posle uklanjanja malignih tumora
VL  - 63
IS  - 9
SP  - 801
EP  - 806
DO  - 10.2298/VSP0609801V
ER  - 
@article{
author = "Vukadinović, Miroslav and Petrović, Milan and Jezdić, Zoran",
year = "2006",
abstract = "Background/aim: Lip carcinoma makes about 1/4 of all oral carcinomas. Primary treatment of the lower lip carcinoma means radical excision of the full thickness of the lower lip tissue together with the tumor. The reconstruction of the defect accomplished after the removal of the lower lip tumor is a challenge for the surgeon and requires a detailed preoperative planning, the right choice of the method for reconstruction and the knowledge of the adequate surgical techniques needed. The aim of this study was to present a ten-year clinical results and experience concerning the reconstruction of lower lip defects longer than 4 cm by means of the modified Fries method in patients treated for the lower lip carcinoma. Methods. The reconstruction of the lower lip by means of the modified Fries method was performed in 37 patients. The following parameters were analyzed: sex, age, the time elapsed from the occurrence of the first symptoms until the first consultation with the doctor, the size of tumors, the size of the postexcision defect, TNM classification, the application of side diagnostic procedures, pathohistological diagnosis of postoperative complications. The sensibility of the lower lip region was monitored, as well as the obtained esthetic effects. Results. The results classified according to the mentioned parameters were processed, analyzed and displayed in detail. Clinical experience concerning the application of this reconstruction technique was presented and analyzed. Conclusion. The modified Fries technique can successfully be applied in the reconstruction of the lower lip defects longer than 4 cm because its application leads to satisfactory functional and acceptable esthetic results., Uvod/cilj: Karcinomi usana čine približno oko 1/4 svih karcinoma usne duplje. Primarno lečenje karcinoma donje usne podrazumeva radikalnu eksciziju pune debljine tkiva donje usne zajedno sa tumorom. Nadoknada defekta nastalog nakon uklanjanja tumora donje usne predstavlja izazov za hirurga i zahteva detaljno preoperativno planiranje, pravilan izbor načina rekonstrukcije i poznavanje odgovarajućih hirurških tehnika. Cilj rada je da se kroz desetogodišnju retrospektivnu studiju prikažu naši klinički rezultati i iskustva u nadoknadi velikih defekata donje usne modifikovanom metodom po Friesu kod bolesnika lečenih od karcinoma donje usne. Metode. Od 256 bolesnika lečenih zbog tumora donje usne u periodu od 1992. do 2001. godine, kod 37 je primenjena rekonstrukcija modifikovanom metodom po Friesu. Analizirani su sledeći parametri: pol i godine starosti bolesnika, vreme proteklo od pojave prvih simptoma do javljanja lekaru, veličina tumora, veličina postekscizionog defekta, TNM klasifikacija, primena pomoćnih dijagnostičkih procedura, patohistološka dijagnoza, postoperativne komplikacije. Beležena su opažanja bolesnika u vezi senzibiliteta predela donje usne. Procenjivani su i ostvareni estetski efekti. Rezultati. Detaljno su obrađeni, analizirani i prikazani rezultati po navedenim parametrima. Izneta su naša klinička iskustva u primeni ove tehnike rekonstrukcije. Analizirane su njene prednosti i mane. Zaključak. Modifikovana tehnika po Friesu može se uspešno primeniti u rekonstrukciji defekata donje usne većih od 4 cm do potpunog nedostatka donje usne, jer se njenom primenom ostvaruju zadovoljavajući funkcionalni i prihvatljivi estetski rezultati.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor, Primena modifikovane metode po Friesu u rekonstrukciji donje usne posle uklanjanja malignih tumora",
volume = "63",
number = "9",
pages = "801-806",
doi = "10.2298/VSP0609801V"
}
Vukadinović, M., Petrović, M.,& Jezdić, Z.. (2006). Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 63(9), 801-806.
https://doi.org/10.2298/VSP0609801V
Vukadinović M, Petrović M, Jezdić Z. Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor. in Vojnosanitetski pregled. 2006;63(9):801-806.
doi:10.2298/VSP0609801V .
Vukadinović, Miroslav, Petrović, Milan, Jezdić, Zoran, "Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor" in Vojnosanitetski pregled, 63, no. 9 (2006):801-806,
https://doi.org/10.2298/VSP0609801V . .

The prevalence of craniomandibular disorders in the military population of the Republic of Serbia

Dodić, Slobodan; Stanišić-Sinobad, Darinka; Vukadinović, Miroslav; Milić, Aleksandra; Sinobad, Vladimir

(Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad, 2006)

TY  - JOUR
AU  - Dodić, Slobodan
AU  - Stanišić-Sinobad, Darinka
AU  - Vukadinović, Miroslav
AU  - Milić, Aleksandra
AU  - Sinobad, Vladimir
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1301
AB  - Introduction. The aim of this study was to determine the prevalence of cra- niomandibular dysfunction (CMD) in the military personel of the Republic of Serbia, as well as the distribution of sings and symptoms of CMD in this population group. Material and methods. The epidemiological investigation included 284 male persons between 18-25 years of age. The sample consisted of Military Academy students, and soldiers from different regions of the Republic of Serbia. A questionnaire was designed using Helkimo's clinical dysfunction index and sings and symptoms of CMD were evaluated, namely the anamnestic index (Ai) and the dysfunction index (Di). Results. According to the anamnestic dysfunction index (Ai), 85% of persons among the examined group presented without any symptoms of CMD (Ai=0), 14% had mild symptoms (Ai =1) and 1% had severe symptoms of CMD (Ai=5). Functional analysis of the orofacial system in the examined group (evaluation of dysfunction index - Di) revealed, however, that 70% of solders had at least one sign of CMD, precisely a dysfunction index Di>0. The analysis of signs and symptoms of CMD revealed that disturbances in mandibular kinematics were the most prevalent sign of CMD in this population group, which was confirmed in 56% of examined persons. Disturbed functions of temporomandibular (TM) joints (click, and reciprocal click, deviation and deflection during mandibular opening) were established in 31% of examined persons, and sensitivity of TM joints and masticatory muscles during palpation in 4% of examined persons. Pain during mandibular movements was established only in 1% of examined persons. Conclusion. The results of this investigation point to significant prevalence of Craniomandibular disorders in the examined population group. The incidence of TMJ and masticaory muscle pain in 4% of examined persons and of pain during mandibular movements only in 1% of examined persons, points to presence of mild or initial types of CMD in this population group.
AB  - Cilj istraživanja bio je da se utvrdi učestalost kraniomandibularnih disfunkcija kod vojnih obveznika na teritoriji R. Srbije kao i zastupljenost pojedinih znakova i simptoma kraniomandibularne disfunkcije u ovoj popularnoj grupi. Epidemiološka istraživanja su obuhvatila grupu od 284 osobe muškog pola (pitomci vojne akademije i vojni obveznici iz različitih regiona Republike Srbije uzrasta 18-25 godina). Za potrebe ovih istraživanja korišćen je upitnik odnosno anamnestički indeks i indeks disfunkcije prema Helkimu istraživanja su pokazala da 85% ispitanika u anamnezi ne navodi bilo kakve simptome kraniomandibularnih disfunkcija (anamnesticilni indeks=0) 14% navodi postojale blagih simptoma (anamnesticilm indeks=1) dok 1% navodi izrazite simptome ovih poremećaja (anamnestički indeks=5). Funkcijska analiza orofacijalnog sistema (vrednovanje indesa disfunkcije indeks disfunkcije)ukazuje, međutim, da 70% vojnih obveznika ima bar neki znak kraniomandibularne disfunkcije odnosno indeks disfunkcije (indeks disfunkcije veći od nule). Analizom pojedinih znakova i simptoma kraniomandibularne disfunkcije utvrđeno je da je poremećena pokretljivost donje vilice najzastupljeniji znak kraniomandibularne disfunkcije u ovoj populacionoj grupi utvrđen kod 56% ispitanika. Poremećaji u funkcionisanju temporomandibularnih zglobova (zvučni signali, devijacije, defleksije mandibule pri otvaranju usta utvrđeni su kod 31% ispitanika, a palpatorna osetljivost temporomandibularnog zgloba, mastikatornih mišića kod 4% ispitanika. Bolne senzacije pri kretnjama donje vilice utvrđene su kod 1% ispitanika. Istraživanja ukazuju na značajnu učestalost kraniomandibularne disfunkcije u ispitivanoj populacionoj grupi. Činjenice da se palpatorna osetljivost temporomandibularnog zgloba mastikatornih mišića sreće samo kod 4% ispitanika a bolna osetljivost samo kod 1% ispitanika ukazuju da se radi o blagim odnosno početnim oblicima kraniomandibularnih disfunkcija.
PB  - Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad
T2  - Medicinski pregled
T1  - The prevalence of craniomandibular disorders in the military population of the Republic of Serbia
T1  - Učestalost kraniomandibularnih disfunkcija u populaciji vojnika Republike Srbije
VL  - 59
IS  - 5-6
SP  - 259
EP  - 264
DO  - 10.2298/MPNS0606259D
ER  - 
@article{
author = "Dodić, Slobodan and Stanišić-Sinobad, Darinka and Vukadinović, Miroslav and Milić, Aleksandra and Sinobad, Vladimir",
year = "2006",
abstract = "Introduction. The aim of this study was to determine the prevalence of cra- niomandibular dysfunction (CMD) in the military personel of the Republic of Serbia, as well as the distribution of sings and symptoms of CMD in this population group. Material and methods. The epidemiological investigation included 284 male persons between 18-25 years of age. The sample consisted of Military Academy students, and soldiers from different regions of the Republic of Serbia. A questionnaire was designed using Helkimo's clinical dysfunction index and sings and symptoms of CMD were evaluated, namely the anamnestic index (Ai) and the dysfunction index (Di). Results. According to the anamnestic dysfunction index (Ai), 85% of persons among the examined group presented without any symptoms of CMD (Ai=0), 14% had mild symptoms (Ai =1) and 1% had severe symptoms of CMD (Ai=5). Functional analysis of the orofacial system in the examined group (evaluation of dysfunction index - Di) revealed, however, that 70% of solders had at least one sign of CMD, precisely a dysfunction index Di>0. The analysis of signs and symptoms of CMD revealed that disturbances in mandibular kinematics were the most prevalent sign of CMD in this population group, which was confirmed in 56% of examined persons. Disturbed functions of temporomandibular (TM) joints (click, and reciprocal click, deviation and deflection during mandibular opening) were established in 31% of examined persons, and sensitivity of TM joints and masticatory muscles during palpation in 4% of examined persons. Pain during mandibular movements was established only in 1% of examined persons. Conclusion. The results of this investigation point to significant prevalence of Craniomandibular disorders in the examined population group. The incidence of TMJ and masticaory muscle pain in 4% of examined persons and of pain during mandibular movements only in 1% of examined persons, points to presence of mild or initial types of CMD in this population group., Cilj istraživanja bio je da se utvrdi učestalost kraniomandibularnih disfunkcija kod vojnih obveznika na teritoriji R. Srbije kao i zastupljenost pojedinih znakova i simptoma kraniomandibularne disfunkcije u ovoj popularnoj grupi. Epidemiološka istraživanja su obuhvatila grupu od 284 osobe muškog pola (pitomci vojne akademije i vojni obveznici iz različitih regiona Republike Srbije uzrasta 18-25 godina). Za potrebe ovih istraživanja korišćen je upitnik odnosno anamnestički indeks i indeks disfunkcije prema Helkimu istraživanja su pokazala da 85% ispitanika u anamnezi ne navodi bilo kakve simptome kraniomandibularnih disfunkcija (anamnesticilni indeks=0) 14% navodi postojale blagih simptoma (anamnesticilm indeks=1) dok 1% navodi izrazite simptome ovih poremećaja (anamnestički indeks=5). Funkcijska analiza orofacijalnog sistema (vrednovanje indesa disfunkcije indeks disfunkcije)ukazuje, međutim, da 70% vojnih obveznika ima bar neki znak kraniomandibularne disfunkcije odnosno indeks disfunkcije (indeks disfunkcije veći od nule). Analizom pojedinih znakova i simptoma kraniomandibularne disfunkcije utvrđeno je da je poremećena pokretljivost donje vilice najzastupljeniji znak kraniomandibularne disfunkcije u ovoj populacionoj grupi utvrđen kod 56% ispitanika. Poremećaji u funkcionisanju temporomandibularnih zglobova (zvučni signali, devijacije, defleksije mandibule pri otvaranju usta utvrđeni su kod 31% ispitanika, a palpatorna osetljivost temporomandibularnog zgloba, mastikatornih mišića kod 4% ispitanika. Bolne senzacije pri kretnjama donje vilice utvrđene su kod 1% ispitanika. Istraživanja ukazuju na značajnu učestalost kraniomandibularne disfunkcije u ispitivanoj populacionoj grupi. Činjenice da se palpatorna osetljivost temporomandibularnog zgloba mastikatornih mišića sreće samo kod 4% ispitanika a bolna osetljivost samo kod 1% ispitanika ukazuju da se radi o blagim odnosno početnim oblicima kraniomandibularnih disfunkcija.",
publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad",
journal = "Medicinski pregled",
title = "The prevalence of craniomandibular disorders in the military population of the Republic of Serbia, Učestalost kraniomandibularnih disfunkcija u populaciji vojnika Republike Srbije",
volume = "59",
number = "5-6",
pages = "259-264",
doi = "10.2298/MPNS0606259D"
}
Dodić, S., Stanišić-Sinobad, D., Vukadinović, M., Milić, A.,& Sinobad, V.. (2006). The prevalence of craniomandibular disorders in the military population of the Republic of Serbia. in Medicinski pregled
Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad., 59(5-6), 259-264.
https://doi.org/10.2298/MPNS0606259D
Dodić S, Stanišić-Sinobad D, Vukadinović M, Milić A, Sinobad V. The prevalence of craniomandibular disorders in the military population of the Republic of Serbia. in Medicinski pregled. 2006;59(5-6):259-264.
doi:10.2298/MPNS0606259D .
Dodić, Slobodan, Stanišić-Sinobad, Darinka, Vukadinović, Miroslav, Milić, Aleksandra, Sinobad, Vladimir, "The prevalence of craniomandibular disorders in the military population of the Republic of Serbia" in Medicinski pregled, 59, no. 5-6 (2006):259-264,
https://doi.org/10.2298/MPNS0606259D . .
5
5

The relationship of occlusal disharmonies and symptoms of temporomandibular disorders

Dodić, Slobodan; Stanišić-Sinobad, Darinka; Vukadinović, Miroslav

(Srpsko lekarsko društvo, Beograd, 2006)

TY  - JOUR
AU  - Dodić, Slobodan
AU  - Stanišić-Sinobad, Darinka
AU  - Vukadinović, Miroslav
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1278
AB  - Introduction: The influence of occlusal condition on the onset of temporomandibular disorder (TMD) has been strongly debated for many years and is still the source of controversy. Until 1980s, the occlusal factors such as the presence of uncured malocclusions, discrepancies between intercuspal position (ICP) and retruded contact position (RCP) greater than two millimeters, occlusal abnormality, particularly mediotrusion and retrusion, and loss of posterior teeth were considered the primary causes of TMD. Objective: The objective of our study was to find correlation of occlusion disharmonies (difference between ICP and RCP) and present sings and symptoms of TMD. Method: The study involved 60 subjects between 18 and 26 years of age who were divided in two groups. The study group consisted of 30 subjects between 18 and 26 years of age with sings and symptoms of temporomandibular disorders (TMD). TMD was confirmed according to Helkimo index. An average value of Helkimo index in this group was 1. The control group included 30 subjects between 20 and 25 years of age without TMD sings and symptoms. An average value of Helkimo index in this group was 0. The function analysis of cinematic centers position in RCP and ICP was performed in each subject using the computer pantograph Arcus-Digma (KaVo EWL GmbH, Leutkirch, Germany). Results: The results of our study showed that the translation tracing of cinematic points from RCP to ICP was significantly different in TMD subjects and asymptomatic group (p>0.16). In addition, the study revealed that 53.4 % of subjects with sings and symptoms of temporomandibular disorders had marked translation in the lower temporomandibular joint (0.61-1.2 mm) what directed to intracapsular disorders. Conclusion: The results of our study suggested significant difference of RCP and ICP between subjects with sings and symptoms of the temporomandibular disorders and subjects without sings and symptoms.
AB  - Uvod: Uloga okluzalnih disharmonija u etiologiji temporomandibularnih disfunkcija (TMD) još uvek je kontroverzno pitanje u stručnoj literaturi i kliničkoj praksi. Do osamdeseti h godina prošlog veka smatralo se da su etiološki faktori presudni za nastanak TMD: okluzalni faktori (poput određenih malokluzija), razlike između retrudovanog kontaktnog položaja (RKP) i interkuspalnog položaja (IKP) veće od 2 mm, postojanje okluzalnih smetnji (naročito mediotruzijskih i retruzijskih), kao i gubitak bočnih zuba. Cilj rada: Cilj rada bilo je utvrđivanje veze između okluzalnih disharmonija (razlika između RKP i IKP) i prisutnih znakova (simptoma) TMD. Metod rada: Istraživanjem je obuhvaćeno 60 ispitanika oba pola, starosti od 18 do 26 godina, podeljenih u dve grupe. Studijsku grupu činilo je 30 ispitanika očuvane prirodne okluzije, sa utvrđenim određenim znacima (simptomima) TMD (indeks disfunkcije po Helkimu bio je veći od 1). Kontrolnu grupu činilo je 30 ispitanika očuvane prirodne okluzije, bez registrovanih znakova (simptoma) TMD (indeks disfunkcije po Helkimu bio je jednak 0). Funkcionalna analiza pozicije kinematskih centara u RKP i IKP (EPA te st) vršena je pomoću kompjuterskog pantografa "arkus digma" (proizvođača KaVo EWL GmbH, Lojtkirh, Nemačka). Rezultati: Rezultati su pokazali da je translat orno pomeranje kinematskog cent ra rotacije na relaciji RKP-IKP (mereno na nivou zgloba) signifikantno veće kod ispitanika sa simptomima TMD (p>0,16). Izrazit translatorni pomak u donjem zglobnom prostoru (0,61−1,2 mm) imalo je 53,4% ispitanika iz ove grupe, što upućuje na prisustvo intrakapsularnih poremećaja. Zaključak: Ustanovljeno je postojanje signifikantnih razlika između RKP i IKP kod ispitanika sa znacima i simptomima temporomandibularnih disfunkcija i ispitanika bez ovih znakova.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The relationship of occlusal disharmonies and symptoms of temporomandibular disorders
T1  - Povezanost okluzalnih disharmonija i simptoma temporomandibularnih disfunkcija
VL  - 134
IS  - 9-10
SP  - 380
EP  - 385
DO  - 10.2298/SARH0610380D
ER  - 
@article{
author = "Dodić, Slobodan and Stanišić-Sinobad, Darinka and Vukadinović, Miroslav",
year = "2006",
abstract = "Introduction: The influence of occlusal condition on the onset of temporomandibular disorder (TMD) has been strongly debated for many years and is still the source of controversy. Until 1980s, the occlusal factors such as the presence of uncured malocclusions, discrepancies between intercuspal position (ICP) and retruded contact position (RCP) greater than two millimeters, occlusal abnormality, particularly mediotrusion and retrusion, and loss of posterior teeth were considered the primary causes of TMD. Objective: The objective of our study was to find correlation of occlusion disharmonies (difference between ICP and RCP) and present sings and symptoms of TMD. Method: The study involved 60 subjects between 18 and 26 years of age who were divided in two groups. The study group consisted of 30 subjects between 18 and 26 years of age with sings and symptoms of temporomandibular disorders (TMD). TMD was confirmed according to Helkimo index. An average value of Helkimo index in this group was 1. The control group included 30 subjects between 20 and 25 years of age without TMD sings and symptoms. An average value of Helkimo index in this group was 0. The function analysis of cinematic centers position in RCP and ICP was performed in each subject using the computer pantograph Arcus-Digma (KaVo EWL GmbH, Leutkirch, Germany). Results: The results of our study showed that the translation tracing of cinematic points from RCP to ICP was significantly different in TMD subjects and asymptomatic group (p>0.16). In addition, the study revealed that 53.4 % of subjects with sings and symptoms of temporomandibular disorders had marked translation in the lower temporomandibular joint (0.61-1.2 mm) what directed to intracapsular disorders. Conclusion: The results of our study suggested significant difference of RCP and ICP between subjects with sings and symptoms of the temporomandibular disorders and subjects without sings and symptoms., Uvod: Uloga okluzalnih disharmonija u etiologiji temporomandibularnih disfunkcija (TMD) još uvek je kontroverzno pitanje u stručnoj literaturi i kliničkoj praksi. Do osamdeseti h godina prošlog veka smatralo se da su etiološki faktori presudni za nastanak TMD: okluzalni faktori (poput određenih malokluzija), razlike između retrudovanog kontaktnog položaja (RKP) i interkuspalnog položaja (IKP) veće od 2 mm, postojanje okluzalnih smetnji (naročito mediotruzijskih i retruzijskih), kao i gubitak bočnih zuba. Cilj rada: Cilj rada bilo je utvrđivanje veze između okluzalnih disharmonija (razlika između RKP i IKP) i prisutnih znakova (simptoma) TMD. Metod rada: Istraživanjem je obuhvaćeno 60 ispitanika oba pola, starosti od 18 do 26 godina, podeljenih u dve grupe. Studijsku grupu činilo je 30 ispitanika očuvane prirodne okluzije, sa utvrđenim određenim znacima (simptomima) TMD (indeks disfunkcije po Helkimu bio je veći od 1). Kontrolnu grupu činilo je 30 ispitanika očuvane prirodne okluzije, bez registrovanih znakova (simptoma) TMD (indeks disfunkcije po Helkimu bio je jednak 0). Funkcionalna analiza pozicije kinematskih centara u RKP i IKP (EPA te st) vršena je pomoću kompjuterskog pantografa "arkus digma" (proizvođača KaVo EWL GmbH, Lojtkirh, Nemačka). Rezultati: Rezultati su pokazali da je translat orno pomeranje kinematskog cent ra rotacije na relaciji RKP-IKP (mereno na nivou zgloba) signifikantno veće kod ispitanika sa simptomima TMD (p>0,16). Izrazit translatorni pomak u donjem zglobnom prostoru (0,61−1,2 mm) imalo je 53,4% ispitanika iz ove grupe, što upućuje na prisustvo intrakapsularnih poremećaja. Zaključak: Ustanovljeno je postojanje signifikantnih razlika između RKP i IKP kod ispitanika sa znacima i simptomima temporomandibularnih disfunkcija i ispitanika bez ovih znakova.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The relationship of occlusal disharmonies and symptoms of temporomandibular disorders, Povezanost okluzalnih disharmonija i simptoma temporomandibularnih disfunkcija",
volume = "134",
number = "9-10",
pages = "380-385",
doi = "10.2298/SARH0610380D"
}
Dodić, S., Stanišić-Sinobad, D.,& Vukadinović, M.. (2006). The relationship of occlusal disharmonies and symptoms of temporomandibular disorders. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 134(9-10), 380-385.
https://doi.org/10.2298/SARH0610380D
Dodić S, Stanišić-Sinobad D, Vukadinović M. The relationship of occlusal disharmonies and symptoms of temporomandibular disorders. in Srpski arhiv za celokupno lekarstvo. 2006;134(9-10):380-385.
doi:10.2298/SARH0610380D .
Dodić, Slobodan, Stanišić-Sinobad, Darinka, Vukadinović, Miroslav, "The relationship of occlusal disharmonies and symptoms of temporomandibular disorders" in Srpski arhiv za celokupno lekarstvo, 134, no. 9-10 (2006):380-385,
https://doi.org/10.2298/SARH0610380D . .
2
2

Roentgencraniometric evaluation of the craniofacial dimensions in subjects with symptoms of temporomandibular disorders

Dodić, Slobodan; Vukadinović, Miroslav; Sinobad, Vladimir

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2006)

TY  - JOUR
AU  - Dodić, Slobodan
AU  - Vukadinović, Miroslav
AU  - Sinobad, Vladimir
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1272
AB  - Background/aim: The aim of this study was to evaluate the possible association between certain morphologic features of the craniofacial skeleton and the presence of symptoms of temporomandibular disorders in young subjects with natural dentitions. Methods. The investigation was carried out on 80 lateral cephalometric radiographs of two groups of male and female subjects between 18 and 25 years of age with natural dentitions. The analysed group consisted of 30 subjects with symptoms of temporomandibular disorders, and the control group of 50 subjects without such symptoms. According to the values of the ANB angle (position of the maxilla with the mandible- Steiner cephalometric analysis) all subjects were classified in the skeletal class 1. The roentgen craniometric analysis of cephalometric radiographs included the evaluation of 25 linear dimensions which values were compared between the examined groups and with the values of the same dimensions in the Bolton standards for 18 years of age. Results. The results of this study confirmed the presence of significant differences between the examined linear dimensions in the Bolton standards and the same dimensions measured in the subjects of the analyzed and the control group. The comparative analysis of these values between the groups confirmed the presence of significant differences in following linear dimensions at the level of p lt 0,00: S - Cs(Go), Mol - PP, Mol - MP and Ar - Go. Conclusion. Significant differences between the examined linear dimensions measured in the subjects included in this study and the same dimensions in the Bolton standards can be explained by specific morphologic features of the craniofacial skeleton in people of our population. Within the limitation of this study, the minor differences in the values of the examined linear variables between the subjects of the experimental and the control group can not be accepted as indicators of disturbed function of the orofacial system.
AB  - Uvod/cilj: Ovo istraživanje je sprovedeno sa ciljem da se utvrdi eventualna veza između određenih morfoloških karakteristika kraniofacijalnog skeleta i prisutnih simptoma temporomandibularnih disfunkcija (TMD) kod mladih osoba sa prirodnom denticijom. Metode. Istraživanja su obavljena na 80 profilnih teleradiografskih snimaka načinjenih kod dve grupe ispitanika muškog i ženskog pola, starosti između 18 i 25 godina sa očuvanim prirodnim zubalom. Analiziranu grupu činilo je 30 ispitanika sa simptomima temporomandibularnih poremećaja, a kontrolnu 50 ispitanika bez takvih simptoma. Prema vrednostima ugla ANB (položaj maksile u odnosu na madibulu-Steinerova kefalometrijska analiza) svi ispitanici su klasifikovani u skeletnu klasu I. Rendgenkraniometrijska analiza obavljena na svakoj profilnoj teleradiografiji obuhvatila je vrednovanje 25 linearnih dimenzija čije su vrednosti upoređivane između ispitivanih grupa, kao i sa vrednostima istih dimenzija u Boltonovim standardima za uzrast od 18 godina. Rezultati. Rezultati ove studije ukazali su na značajne razlike između ispitivanih linearnih dimenzija prema Boltonovim standardima i istih vrednosti izmerenih u eksperimentalnoj i u kontrolnoj grupi. Uporedna analiza ovih vrednosti između ispitivanih grupa pokazala je da statistički značajne razlike postoje u sledećim dimenzijama na nivou verovatnoće od p lt  0,001: S-Cs(Go), Mol-PP, Mol- MP i Ar-Go. Zaključak. Značajne razlike između ispitivanih linearnih dimenzija izmerenih kod ispitanika uključenih u ovu studiju i istih dimenzija u Boltonovim standardima verovatno su vezane za specifičnosti kraniofacijalnog skeleta kod naše populacije. Imajući u vidu specifičnosti ove studije, neznatne razlike u vrednostima ispitivanih linearnih varijabli između ispitanika analizirane i kontrolne grupe ne mogu se smatrati indikatorima poremećene funkcije orofacijalnog sistema.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Roentgencraniometric evaluation of the craniofacial dimensions in subjects with symptoms of temporomandibular disorders
T1  - Rendgenkraniometrijska evaluacija kraniofacijalnih dimenzija kod osoba sa simptomima temporomandibularnih disfunkcija
VL  - 63
IS  - 9
SP  - 793
EP  - 799
DO  - 10.2298/VSP0609793D
ER  - 
@article{
author = "Dodić, Slobodan and Vukadinović, Miroslav and Sinobad, Vladimir",
year = "2006",
abstract = "Background/aim: The aim of this study was to evaluate the possible association between certain morphologic features of the craniofacial skeleton and the presence of symptoms of temporomandibular disorders in young subjects with natural dentitions. Methods. The investigation was carried out on 80 lateral cephalometric radiographs of two groups of male and female subjects between 18 and 25 years of age with natural dentitions. The analysed group consisted of 30 subjects with symptoms of temporomandibular disorders, and the control group of 50 subjects without such symptoms. According to the values of the ANB angle (position of the maxilla with the mandible- Steiner cephalometric analysis) all subjects were classified in the skeletal class 1. The roentgen craniometric analysis of cephalometric radiographs included the evaluation of 25 linear dimensions which values were compared between the examined groups and with the values of the same dimensions in the Bolton standards for 18 years of age. Results. The results of this study confirmed the presence of significant differences between the examined linear dimensions in the Bolton standards and the same dimensions measured in the subjects of the analyzed and the control group. The comparative analysis of these values between the groups confirmed the presence of significant differences in following linear dimensions at the level of p lt 0,00: S - Cs(Go), Mol - PP, Mol - MP and Ar - Go. Conclusion. Significant differences between the examined linear dimensions measured in the subjects included in this study and the same dimensions in the Bolton standards can be explained by specific morphologic features of the craniofacial skeleton in people of our population. Within the limitation of this study, the minor differences in the values of the examined linear variables between the subjects of the experimental and the control group can not be accepted as indicators of disturbed function of the orofacial system., Uvod/cilj: Ovo istraživanje je sprovedeno sa ciljem da se utvrdi eventualna veza između određenih morfoloških karakteristika kraniofacijalnog skeleta i prisutnih simptoma temporomandibularnih disfunkcija (TMD) kod mladih osoba sa prirodnom denticijom. Metode. Istraživanja su obavljena na 80 profilnih teleradiografskih snimaka načinjenih kod dve grupe ispitanika muškog i ženskog pola, starosti između 18 i 25 godina sa očuvanim prirodnim zubalom. Analiziranu grupu činilo je 30 ispitanika sa simptomima temporomandibularnih poremećaja, a kontrolnu 50 ispitanika bez takvih simptoma. Prema vrednostima ugla ANB (položaj maksile u odnosu na madibulu-Steinerova kefalometrijska analiza) svi ispitanici su klasifikovani u skeletnu klasu I. Rendgenkraniometrijska analiza obavljena na svakoj profilnoj teleradiografiji obuhvatila je vrednovanje 25 linearnih dimenzija čije su vrednosti upoređivane između ispitivanih grupa, kao i sa vrednostima istih dimenzija u Boltonovim standardima za uzrast od 18 godina. Rezultati. Rezultati ove studije ukazali su na značajne razlike između ispitivanih linearnih dimenzija prema Boltonovim standardima i istih vrednosti izmerenih u eksperimentalnoj i u kontrolnoj grupi. Uporedna analiza ovih vrednosti između ispitivanih grupa pokazala je da statistički značajne razlike postoje u sledećim dimenzijama na nivou verovatnoće od p lt  0,001: S-Cs(Go), Mol-PP, Mol- MP i Ar-Go. Zaključak. Značajne razlike između ispitivanih linearnih dimenzija izmerenih kod ispitanika uključenih u ovu studiju i istih dimenzija u Boltonovim standardima verovatno su vezane za specifičnosti kraniofacijalnog skeleta kod naše populacije. Imajući u vidu specifičnosti ove studije, neznatne razlike u vrednostima ispitivanih linearnih varijabli između ispitanika analizirane i kontrolne grupe ne mogu se smatrati indikatorima poremećene funkcije orofacijalnog sistema.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Roentgencraniometric evaluation of the craniofacial dimensions in subjects with symptoms of temporomandibular disorders, Rendgenkraniometrijska evaluacija kraniofacijalnih dimenzija kod osoba sa simptomima temporomandibularnih disfunkcija",
volume = "63",
number = "9",
pages = "793-799",
doi = "10.2298/VSP0609793D"
}
Dodić, S., Vukadinović, M.,& Sinobad, V.. (2006). Roentgencraniometric evaluation of the craniofacial dimensions in subjects with symptoms of temporomandibular disorders. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 63(9), 793-799.
https://doi.org/10.2298/VSP0609793D
Dodić S, Vukadinović M, Sinobad V. Roentgencraniometric evaluation of the craniofacial dimensions in subjects with symptoms of temporomandibular disorders. in Vojnosanitetski pregled. 2006;63(9):793-799.
doi:10.2298/VSP0609793D .
Dodić, Slobodan, Vukadinović, Miroslav, Sinobad, Vladimir, "Roentgencraniometric evaluation of the craniofacial dimensions in subjects with symptoms of temporomandibular disorders" in Vojnosanitetski pregled, 63, no. 9 (2006):793-799,
https://doi.org/10.2298/VSP0609793D . .

Changes of the upper lip after surgical correction of mandibular prognathism

Vukadinović, Miroslav; Aničić, Boban; Jezdić, Zoran; Miković, Nikola; Sinobad, Vladimir

(Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš, 2005)

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Aničić, Boban
AU  - Jezdić, Zoran
AU  - Miković, Nikola
AU  - Sinobad, Vladimir
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1259
AB  - The aim of this study was to establish and estimate the effects of surgical correction of mandibular prognathism on the height and position of the upper lip. The changes of the upper lip were analyzed on 115 patients between 16 and 30 year of age (71 females and 44 males) who were subject to surgical correction of mandibular prognathism using the sagittal split ramus osteotomy. The lateral cephalometric radiographs were taken of each patient before and six months after the surgical procedure. The soft tissue cephalometric analysis included the measurements of six linear and two angular parameters. The obtained data were statistically processed and evaluated. Statistical analysis revealed the significant changes in two linear cephalometric parameters after surgical procedure - the incisal step and the length of the upper lip. The changes in the length and position of the upper lip after surgical correction of mandibular prognathism by means of sagittal split ramus osteotomy seem to be minor and clinically insignificant. Only the length of the upper lip was significantly changed. It became longer. The upper lip advancement amounted approximately 15% of the complete mandibular set-back during operation.
AB  - Cilj istraživanja je bio da utvrdi i proceni efekte hirurške korekcije mandibularnog prognatizma na dužinu i položaj gornje usne. Promene gornje usne su kefalometrijski analizirane kod 115 osoba (f=71; m=44) kod kojih je mandibularni prognatizam korigovan metodom sagitalnih osteotomija grane donje vilice. Svakom pacijentu su načinjena po dva profilna telerendgenska snimka glave, jedan pre i jedan nakon hirurške intervencije. Kefalometrijska analiza mekog profila lica je obavljena merenjem i poređenjem šest linearnih i dva angularna parametra. Dobijene vrednosti su statistički obrađene i evoluirane. Primenjene hirurške korektivne procedure rezultirale su statistički značajnim promenama kod dva linearna parametra (incizalna stepenica i dužina gornje usne). Promene gornje usne posle hirurške korekcije mandibularnog prognatizma pomoću sagitalnih klizajućih osteotomija grane donje vilice su minimalne i gotovo neznačajne. Značajno se menja jedino dužina gornje usne - postaje duža. Gornja usna se pomera za 15% ukupnog pomeranja struktura donje vilice.
PB  - Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš
T2  - Acta stomatologica Naissi
T1  - Changes of the upper lip after surgical correction of mandibular prognathism
T1  - Promene gornje usne posle hirurške korekcije progenije
VL  - 21
IS  - 52
SP  - 527
EP  - 534
UR  - https://hdl.handle.net/21.15107/rcub_smile_1259
ER  - 
@article{
author = "Vukadinović, Miroslav and Aničić, Boban and Jezdić, Zoran and Miković, Nikola and Sinobad, Vladimir",
year = "2005",
abstract = "The aim of this study was to establish and estimate the effects of surgical correction of mandibular prognathism on the height and position of the upper lip. The changes of the upper lip were analyzed on 115 patients between 16 and 30 year of age (71 females and 44 males) who were subject to surgical correction of mandibular prognathism using the sagittal split ramus osteotomy. The lateral cephalometric radiographs were taken of each patient before and six months after the surgical procedure. The soft tissue cephalometric analysis included the measurements of six linear and two angular parameters. The obtained data were statistically processed and evaluated. Statistical analysis revealed the significant changes in two linear cephalometric parameters after surgical procedure - the incisal step and the length of the upper lip. The changes in the length and position of the upper lip after surgical correction of mandibular prognathism by means of sagittal split ramus osteotomy seem to be minor and clinically insignificant. Only the length of the upper lip was significantly changed. It became longer. The upper lip advancement amounted approximately 15% of the complete mandibular set-back during operation., Cilj istraživanja je bio da utvrdi i proceni efekte hirurške korekcije mandibularnog prognatizma na dužinu i položaj gornje usne. Promene gornje usne su kefalometrijski analizirane kod 115 osoba (f=71; m=44) kod kojih je mandibularni prognatizam korigovan metodom sagitalnih osteotomija grane donje vilice. Svakom pacijentu su načinjena po dva profilna telerendgenska snimka glave, jedan pre i jedan nakon hirurške intervencije. Kefalometrijska analiza mekog profila lica je obavljena merenjem i poređenjem šest linearnih i dva angularna parametra. Dobijene vrednosti su statistički obrađene i evoluirane. Primenjene hirurške korektivne procedure rezultirale su statistički značajnim promenama kod dva linearna parametra (incizalna stepenica i dužina gornje usne). Promene gornje usne posle hirurške korekcije mandibularnog prognatizma pomoću sagitalnih klizajućih osteotomija grane donje vilice su minimalne i gotovo neznačajne. Značajno se menja jedino dužina gornje usne - postaje duža. Gornja usna se pomera za 15% ukupnog pomeranja struktura donje vilice.",
publisher = "Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš",
journal = "Acta stomatologica Naissi",
title = "Changes of the upper lip after surgical correction of mandibular prognathism, Promene gornje usne posle hirurške korekcije progenije",
volume = "21",
number = "52",
pages = "527-534",
url = "https://hdl.handle.net/21.15107/rcub_smile_1259"
}
Vukadinović, M., Aničić, B., Jezdić, Z., Miković, N.,& Sinobad, V.. (2005). Changes of the upper lip after surgical correction of mandibular prognathism. in Acta stomatologica Naissi
Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš., 21(52), 527-534.
https://hdl.handle.net/21.15107/rcub_smile_1259
Vukadinović M, Aničić B, Jezdić Z, Miković N, Sinobad V. Changes of the upper lip after surgical correction of mandibular prognathism. in Acta stomatologica Naissi. 2005;21(52):527-534.
https://hdl.handle.net/21.15107/rcub_smile_1259 .
Vukadinović, Miroslav, Aničić, Boban, Jezdić, Zoran, Miković, Nikola, Sinobad, Vladimir, "Changes of the upper lip after surgical correction of mandibular prognathism" in Acta stomatologica Naissi, 21, no. 52 (2005):527-534,
https://hdl.handle.net/21.15107/rcub_smile_1259 .

C-myc amplification in precancerous lesions of oral cavity and larynx

Ninković, Tanja; Dedović, Nasta; Kosanović, Rade; Dimitrijević, Bogomir; Josipović, Obrad; Vukadinović, Miroslav; Milašin, Jelena

(Srpsko lekarsko društvo - Stomatološka sekcija, Beograd, 2003)

TY  - JOUR
AU  - Ninković, Tanja
AU  - Dedović, Nasta
AU  - Kosanović, Rade
AU  - Dimitrijević, Bogomir
AU  - Josipović, Obrad
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2003
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1174
AB  - Although myc genes are an important family of oncogenes involved in human carcinogenesis, data concerning its role in head and neck tumors are quite limited. Moreover, information regarding precancerous lesions is almost inexisting. In order to better understand mechanisms of progression of premalignant lesions into malignant and the possible role of c-myc amplification, the status of this oncogene was analyzed in two types of pathological changes known to possess malignant transformation potential oral leukoplakia and chronic laryngitis. In the first type of lesions a high percentage of c-myc activation (33%) was observed pointing to a probable role of myc in leukoplakia malignant transformation, while in the other type of lesion there were no signs of myc amplification.
AB  - C-myc spada u red onkogena sa važnom ulogom u humanoj kancerogenezi, međutim malo je podataka u literaturi o promenama ovog gena u malignim i premalignim lezijama glave i vrata. Sa ciljem da se bolje upoznaju mehanizmi evolucije prekanceroznih lezija u prave kancere sa naglaskom na c-myc onkogen, analiziran je njegov status u dva tipa promena za koje se zna da imaju maligni potencijal: oralnim leukoplakijama i hroničnim laringitisima. U prvom tipu lezija ustanovljen je visok stepen (33%) aktivacije myc-onkogena, što bi ukazivalo na značaj ove promene u malignoj transformaciji leukoplakija, dok u drugom nije nađen nijedan uzorak sa ovom promenom.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - C-myc amplification in precancerous lesions of oral cavity and larynx
T1  - Amplifikacija c-myc onkogena u prekancerozama usne duplje i larinksa
VL  - 50
IS  - 3
SP  - 117
EP  - 119
DO  - 10.2298/SGS0303117N
ER  - 
@article{
author = "Ninković, Tanja and Dedović, Nasta and Kosanović, Rade and Dimitrijević, Bogomir and Josipović, Obrad and Vukadinović, Miroslav and Milašin, Jelena",
year = "2003",
abstract = "Although myc genes are an important family of oncogenes involved in human carcinogenesis, data concerning its role in head and neck tumors are quite limited. Moreover, information regarding precancerous lesions is almost inexisting. In order to better understand mechanisms of progression of premalignant lesions into malignant and the possible role of c-myc amplification, the status of this oncogene was analyzed in two types of pathological changes known to possess malignant transformation potential oral leukoplakia and chronic laryngitis. In the first type of lesions a high percentage of c-myc activation (33%) was observed pointing to a probable role of myc in leukoplakia malignant transformation, while in the other type of lesion there were no signs of myc amplification., C-myc spada u red onkogena sa važnom ulogom u humanoj kancerogenezi, međutim malo je podataka u literaturi o promenama ovog gena u malignim i premalignim lezijama glave i vrata. Sa ciljem da se bolje upoznaju mehanizmi evolucije prekanceroznih lezija u prave kancere sa naglaskom na c-myc onkogen, analiziran je njegov status u dva tipa promena za koje se zna da imaju maligni potencijal: oralnim leukoplakijama i hroničnim laringitisima. U prvom tipu lezija ustanovljen je visok stepen (33%) aktivacije myc-onkogena, što bi ukazivalo na značaj ove promene u malignoj transformaciji leukoplakija, dok u drugom nije nađen nijedan uzorak sa ovom promenom.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "C-myc amplification in precancerous lesions of oral cavity and larynx, Amplifikacija c-myc onkogena u prekancerozama usne duplje i larinksa",
volume = "50",
number = "3",
pages = "117-119",
doi = "10.2298/SGS0303117N"
}
Ninković, T., Dedović, N., Kosanović, R., Dimitrijević, B., Josipović, O., Vukadinović, M.,& Milašin, J.. (2003). C-myc amplification in precancerous lesions of oral cavity and larynx. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 50(3), 117-119.
https://doi.org/10.2298/SGS0303117N
Ninković T, Dedović N, Kosanović R, Dimitrijević B, Josipović O, Vukadinović M, Milašin J. C-myc amplification in precancerous lesions of oral cavity and larynx. in Stomatološki glasnik Srbije. 2003;50(3):117-119.
doi:10.2298/SGS0303117N .
Ninković, Tanja, Dedović, Nasta, Kosanović, Rade, Dimitrijević, Bogomir, Josipović, Obrad, Vukadinović, Miroslav, Milašin, Jelena, "C-myc amplification in precancerous lesions of oral cavity and larynx" in Stomatološki glasnik Srbije, 50, no. 3 (2003):117-119,
https://doi.org/10.2298/SGS0303117N . .
3

Promene mekih tkiva lica posle hirurške korekcije progenije

Vukadinović, Miroslav

(Univerzitet u Beogradu, Stomatološki fakultet, 1993)

TY  - THES
AU  - Vukadinović, Miroslav
PY  - 1993
UR  - https://plus.sr.cobiss.net/opac7/bib/17823247
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/285
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Promene mekih tkiva lica posle hirurške korekcije progenije
UR  - https://hdl.handle.net/21.15107/rcub_smile_285
ER  - 
@phdthesis{
author = "Vukadinović, Miroslav",
year = "1993",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Promene mekih tkiva lica posle hirurške korekcije progenije",
url = "https://hdl.handle.net/21.15107/rcub_smile_285"
}
Vukadinović, M.. (1993). Promene mekih tkiva lica posle hirurške korekcije progenije. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_285
Vukadinović M. Promene mekih tkiva lica posle hirurške korekcije progenije. 1993;.
https://hdl.handle.net/21.15107/rcub_smile_285 .
Vukadinović, Miroslav, "Promene mekih tkiva lica posle hirurške korekcije progenije" (1993),
https://hdl.handle.net/21.15107/rcub_smile_285 .