TY  - JOUR
AU  - Matić-Petrović, Sanja
AU  - Pucar, Ana
AU  - Jotić, Aleksandra
AU  - Miličić, Biljana
AU  - Arambašić-Jovanović, Jelena
AU  - Vidaković, Melita
AU  - Leković, Vojislav
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2158
AB  - Introduction: The role of tumor necrosis factor-α (TNFα) is well documented in pathogenesis of chronic periodontitis (CP) and type 2 diabetes (T2D). Considering short half-life of TNFα, tumor necrosis factor receptor-2 (TNFR2) is used as prosperous surrogate marker of TNFα activity. Objective The aim was to detect TNFR2 serum concentration and correlate it with periodontal destruction in patients with diagnosed T2D and nondiabetics. Methods The study included 85 patients divided into three groups: T2D + CP (group T2D, n = 34); nondiabetics + CP (Group PD, n = 27); and healthy controls (group HC, n = 24). T2D was diagnosed according to WHO criteria (2013) and periodontitis was diagnosed using International Workshop for a Classification of Periodontal Diseases and Conditions criteria (1999). TNFR2 level was measured by enzyme-linked immunosorbent assay (ELISA). Results There was no difference in TNFR2 level among the groups (Kruskal-Wallis, p = 0.482). Significant correlation (Pearson's correlation coefficient) was observed between clinical attachment loss (CAL) and TNFR2 concentration in PD group (rp = -0.460, p = 0.016). In T2D group, correlations were observed between TNFR2 concentration and CaL (rp = 0.363, p = 0.005) and periodontal inflamed surface area (PISA) (rp = 0.345, p = 0.046) and periodontalepithelial surface area (PESA) (rp = 0.578, p = 0.000). Conclusion Higher concentration of TNFR2 was associated with higher CAL, PESA, and PISA scores in T2D group. Contrary to that, nondiabetics with higher values of CAL exhibited lower concentration of TNFR2, presenting potential protective effect on periodontal destruction. These results imply that diabetes may alter TNFR2 secretion originated from periodontium.
AB  - Uvod: Uloga faktora nekroze tumora-alfa (TNFα) dokazana je u patogenezi hronične parodontopatije (HP) i dijabetesa melitusa tipa 2 (DM tip 2). S obzirom na to da je poluživot TNFα veoma kratak, receptor 2 faktora nekroze tumora (TNFR2) koristi se kao marker aktivnosti TNFα. Cilj rada Cilj ovog rada je određivanje koncentracije TNFR2 u serumu i koreliranje sa parametrima destrukcije parodoncijuma kod zdravih i ispitanika sa dijagnostikovanim DM tip 2. Metode rada U studiju je uključeno 85 pacijenata podeljenih u tri grupe: DM tip 2 + HP (DM grupa, n = 34), zdravi ispitanici + HP (PD grupa, n = 27) i zdrave kontrole (ZK grupa, n = 24). Dijagnoza DM tip 2 postavljena je na osnovu kriterijuma SZO (2013), dok je dijagnoza HP postavljena na osnovu kriterijuma Internacionalne radionice za klasifikaciju stanja i oboljenja parodoncijuma (1999). Koncentracija TNFR2 merena je ELISA metodom. Rezultati Koncentracija serumskog TNFR2 nije se razlikovala među grupama (Kraskal-Volis, p = 0,482). Postoji značajna korelacija (Pirson) između nivoa pripojnog epitela (NPE) i koncentracije TNFR2 u PD grupi (rp = -0,460, p = 0,016). U DM tip 2 grupi, statistički značajna korelacija uočena je između koncentracije TNFR2 i NPE (rp = 0,363, p = 0,005), kao i parametara uticaja inflamacije iz parodoncijuma na sistemsko zdravlje - PISA (rp = 0,345, p = 0,046) i PESA (rp = 0,578, p = 0,000). Zaključak Kod pacijenata sa dijabetesom veće koncentracije TNFR2 odgovaraju većim vrednostima NPE, PESA i PISA. Nasuprot tome, kod sistemski zdravih ispitanika sa HP veće vrednosti NPE su povezane sa manjim koncentracijama TNFR2, što bi moglo govoriti o potencijalnoj zaštitnoj ulozi ovog citokina na destrukciju parodoncijuma. Rezultati govore da dijabetes može uticati na sekreciju TNFR2 iz parodoncijuma.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study
T1  - Korelacija između koncentracije receptora 2 faktora nekroze tumora u serumu i destrukcije parodoncijuma kod bolesnika sa dijabetes melitusom tip 2 - studija preseka
VL  - 144
IS  - 5-6
SP  - 266
EP  - 272
DO  - 10.2298/SARH1606266M
ER  - 

@article{
author = "Matić-Petrović, Sanja and Pucar, Ana and Jotić, Aleksandra and Miličić, Biljana and Arambašić-Jovanović, Jelena and Vidaković, Melita and Leković, Vojislav",
year = "2016",
abstract = "Introduction: The role of tumor necrosis factor-α (TNFα) is well documented in pathogenesis of chronic periodontitis (CP) and type 2 diabetes (T2D). Considering short half-life of TNFα, tumor necrosis factor receptor-2 (TNFR2) is used as prosperous surrogate marker of TNFα activity. Objective The aim was to detect TNFR2 serum concentration and correlate it with periodontal destruction in patients with diagnosed T2D and nondiabetics. Methods The study included 85 patients divided into three groups: T2D + CP (group T2D, n = 34); nondiabetics + CP (Group PD, n = 27); and healthy controls (group HC, n = 24). T2D was diagnosed according to WHO criteria (2013) and periodontitis was diagnosed using International Workshop for a Classification of Periodontal Diseases and Conditions criteria (1999). TNFR2 level was measured by enzyme-linked immunosorbent assay (ELISA). Results There was no difference in TNFR2 level among the groups (Kruskal-Wallis, p = 0.482). Significant correlation (Pearson's correlation coefficient) was observed between clinical attachment loss (CAL) and TNFR2 concentration in PD group (rp = -0.460, p = 0.016). In T2D group, correlations were observed between TNFR2 concentration and CaL (rp = 0.363, p = 0.005) and periodontal inflamed surface area (PISA) (rp = 0.345, p = 0.046) and periodontalepithelial surface area (PESA) (rp = 0.578, p = 0.000). Conclusion Higher concentration of TNFR2 was associated with higher CAL, PESA, and PISA scores in T2D group. Contrary to that, nondiabetics with higher values of CAL exhibited lower concentration of TNFR2, presenting potential protective effect on periodontal destruction. These results imply that diabetes may alter TNFR2 secretion originated from periodontium., Uvod: Uloga faktora nekroze tumora-alfa (TNFα) dokazana je u patogenezi hronične parodontopatije (HP) i dijabetesa melitusa tipa 2 (DM tip 2). S obzirom na to da je poluživot TNFα veoma kratak, receptor 2 faktora nekroze tumora (TNFR2) koristi se kao marker aktivnosti TNFα. Cilj rada Cilj ovog rada je određivanje koncentracije TNFR2 u serumu i koreliranje sa parametrima destrukcije parodoncijuma kod zdravih i ispitanika sa dijagnostikovanim DM tip 2. Metode rada U studiju je uključeno 85 pacijenata podeljenih u tri grupe: DM tip 2 + HP (DM grupa, n = 34), zdravi ispitanici + HP (PD grupa, n = 27) i zdrave kontrole (ZK grupa, n = 24). Dijagnoza DM tip 2 postavljena je na osnovu kriterijuma SZO (2013), dok je dijagnoza HP postavljena na osnovu kriterijuma Internacionalne radionice za klasifikaciju stanja i oboljenja parodoncijuma (1999). Koncentracija TNFR2 merena je ELISA metodom. Rezultati Koncentracija serumskog TNFR2 nije se razlikovala među grupama (Kraskal-Volis, p = 0,482). Postoji značajna korelacija (Pirson) između nivoa pripojnog epitela (NPE) i koncentracije TNFR2 u PD grupi (rp = -0,460, p = 0,016). U DM tip 2 grupi, statistički značajna korelacija uočena je između koncentracije TNFR2 i NPE (rp = 0,363, p = 0,005), kao i parametara uticaja inflamacije iz parodoncijuma na sistemsko zdravlje - PISA (rp = 0,345, p = 0,046) i PESA (rp = 0,578, p = 0,000). Zaključak Kod pacijenata sa dijabetesom veće koncentracije TNFR2 odgovaraju većim vrednostima NPE, PESA i PISA. Nasuprot tome, kod sistemski zdravih ispitanika sa HP veće vrednosti NPE su povezane sa manjim koncentracijama TNFR2, što bi moglo govoriti o potencijalnoj zaštitnoj ulozi ovog citokina na destrukciju parodoncijuma. Rezultati govore da dijabetes može uticati na sekreciju TNFR2 iz parodoncijuma.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study, Korelacija između koncentracije receptora 2 faktora nekroze tumora u serumu i destrukcije parodoncijuma kod bolesnika sa dijabetes melitusom tip 2 - studija preseka",
volume = "144",
number = "5-6",
pages = "266-272",
doi = "10.2298/SARH1606266M"
}

Matić-Petrović, S., Pucar, A., Jotić, A., Miličić, B., Arambašić-Jovanović, J., Vidaković, M.,& Leković, V.. (2016). Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 144(5-6), 266-272.
https://doi.org/10.2298/SARH1606266M

Matić-Petrović S, Pucar A, Jotić A, Miličić B, Arambašić-Jovanović J, Vidaković M, Leković V. Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study. in Srpski arhiv za celokupno lekarstvo. 2016;144(5-6):266-272.
doi:10.2298/SARH1606266M .

Matić-Petrović, Sanja, Pucar, Ana, Jotić, Aleksandra, Miličić, Biljana, Arambašić-Jovanović, Jelena, Vidaković, Melita, Leković, Vojislav, "Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study" in Srpski arhiv za celokupno lekarstvo, 144, no. 5-6 (2016):266-272,
https://doi.org/10.2298/SARH1606266M . .

TY  - JOUR
AU  - Milinković, Iva
AU  - Aleksić, Zoran
AU  - Janković, Saša
AU  - Popović, O.
AU  - Bajić, Miljan
AU  - Čakić, Saša
AU  - Leković, Vojislav
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1977
AB  - Background and ObjectiveGingival recession is defined as soft and hard tissue displacement resulting in root surface exposure. The optimal outcome of gingival recession treatment is complete, predictable and long-lasting root coverage with a significant level of tissue regeneration. Tissue engineering, which applies active regeneration principles, presents the contemporary treatment approach in the restitution and regeneration of lost tissues. The objective of the present study was to evaluate and compare the clinical results of application of an autologous fibroblast cell culture (AFCC) on a collagen matrix and a connective tissue graft (CTG) placed under a coronally advanced flap (CAF), in the treatment of single and multiple gingival recessions. Material and MethodsEighteen patients from the Department of Periodontology, School of Dentistry, University of Belgrade, were randomly enrolled in this study. Inclusion criteria were the bilateral presence of Miller Class I or II single or multiple maxillary gingival recessions. A split-mouth design was used in the study. The experimental group was treated with AFCC on a collagen scaffold, which was placed under a CAF. The control group received a combination of CTG and CAF. Clinical parameters such as gingival recession coverage, keratinized tissue width, clinical attachment level and gingival index were recorded at baseline and at 12mo postoperatively. The oral hygiene level was assessed by plaque index evaluation. Postoperative healing was evaluated through the healing index, recorded 1, 2 and 3wk postoperatively. The final esthetic outcome was assessed using the mean root coverage esthetic score (RES). ResultsStatistically significant improvement of all parameters assessed was found compared with baseline. A statistically significant difference between groups was observed only in keratinized tissue width. Greater keratinized tissue width is still obtained with the use of CTG. Regarding the tissue-healing results, no statistically significant difference was achieved. The RES results were similar for both groups. ConclusionsWithin the limitations of the present study, both procedures proved to be efficient in gingival recession treatment. AFCC, as a novel tissue-engineering concept and living cell-based therapy, proved to be a reliable and successful treatment concept.
PB  - Wiley, Hoboken
T2  - Journal of Periodontal Research
T1  - Clinical application of autologous fibroblast cell culture in gingival recession treatment
VL  - 50
IS  - 3
SP  - 363
EP  - 370
DO  - 10.1111/jre.12215
ER  - 

@article{
author = "Milinković, Iva and Aleksić, Zoran and Janković, Saša and Popović, O. and Bajić, Miljan and Čakić, Saša and Leković, Vojislav",
year = "2015",
abstract = "Background and ObjectiveGingival recession is defined as soft and hard tissue displacement resulting in root surface exposure. The optimal outcome of gingival recession treatment is complete, predictable and long-lasting root coverage with a significant level of tissue regeneration. Tissue engineering, which applies active regeneration principles, presents the contemporary treatment approach in the restitution and regeneration of lost tissues. The objective of the present study was to evaluate and compare the clinical results of application of an autologous fibroblast cell culture (AFCC) on a collagen matrix and a connective tissue graft (CTG) placed under a coronally advanced flap (CAF), in the treatment of single and multiple gingival recessions. Material and MethodsEighteen patients from the Department of Periodontology, School of Dentistry, University of Belgrade, were randomly enrolled in this study. Inclusion criteria were the bilateral presence of Miller Class I or II single or multiple maxillary gingival recessions. A split-mouth design was used in the study. The experimental group was treated with AFCC on a collagen scaffold, which was placed under a CAF. The control group received a combination of CTG and CAF. Clinical parameters such as gingival recession coverage, keratinized tissue width, clinical attachment level and gingival index were recorded at baseline and at 12mo postoperatively. The oral hygiene level was assessed by plaque index evaluation. Postoperative healing was evaluated through the healing index, recorded 1, 2 and 3wk postoperatively. The final esthetic outcome was assessed using the mean root coverage esthetic score (RES). ResultsStatistically significant improvement of all parameters assessed was found compared with baseline. A statistically significant difference between groups was observed only in keratinized tissue width. Greater keratinized tissue width is still obtained with the use of CTG. Regarding the tissue-healing results, no statistically significant difference was achieved. The RES results were similar for both groups. ConclusionsWithin the limitations of the present study, both procedures proved to be efficient in gingival recession treatment. AFCC, as a novel tissue-engineering concept and living cell-based therapy, proved to be a reliable and successful treatment concept.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontal Research",
title = "Clinical application of autologous fibroblast cell culture in gingival recession treatment",
volume = "50",
number = "3",
pages = "363-370",
doi = "10.1111/jre.12215"
}

Milinković, I., Aleksić, Z., Janković, S., Popović, O., Bajić, M., Čakić, S.,& Leković, V.. (2015). Clinical application of autologous fibroblast cell culture in gingival recession treatment. in Journal of Periodontal Research
Wiley, Hoboken., 50(3), 363-370.
https://doi.org/10.1111/jre.12215

Milinković I, Aleksić Z, Janković S, Popović O, Bajić M, Čakić S, Leković V. Clinical application of autologous fibroblast cell culture in gingival recession treatment. in Journal of Periodontal Research. 2015;50(3):363-370.
doi:10.1111/jre.12215 .

Milinković, Iva, Aleksić, Zoran, Janković, Saša, Popović, O., Bajić, Miljan, Čakić, Saša, Leković, Vojislav, "Clinical application of autologous fibroblast cell culture in gingival recession treatment" in Journal of Periodontal Research, 50, no. 3 (2015):363-370,
https://doi.org/10.1111/jre.12215 . .

TY  - JOUR
AU  - Perunović, Neda
AU  - Rakić, Mia
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Struillou, Xavier
AU  - Čakić, Saša
AU  - Puletić, Miljan
AU  - Leković, Vojislav
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2058
AB  - The objective of this pilot study was to investigate the potential role of-1562 C>T single nucleotide polymorphism (SNP) in the promoter region of the matrix metalloproteinase-9 (MMP-9) gene as a risk modulator in the development of multiple gingival recessions (MGRs) in young adults in the Serbian population. The study sample comprised 161 systemically healthy people: 60 with MGRs and 101 controls with healthy periodontal tissues. Genotyping was done using polymerase chain reaction/restriction fragment length polymorphism approach on DNA obtained from buccal swabs. Clinical measurements included vertical recession depth (VRD), clinical attachment level (CAL), keratinized gingival width (KGW), visible plaque index (PI), and bleeding on probing (BOP). Heterozygotes (CT) were significantly more frequent in the MGRs group than in the control group (P = .005) and carriers of the T allele had an approximately threefold increase of MGRs risk. Patients with the CT genotype exhibited significantly higher values of VRD and CAL and significantly lower values of KGW than patients with the wildtype genotype. Associations among different genotypes and periodontal biotypes in the MGRs group remained insignificant because all participants exhibited thin biotype. The 1562 C>T SNP in the promoter region of MMP-9 appears to be a risk factor for MGR development and a potential predictor of more severe clinical phenotype.
PB  - Quintessence Publishing Co. Inc.
T2  - International Journal of Periodontics & Restorative Dentistry
T1  - MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions
VL  - 35
IS  - 2
SP  - 263
EP  - 269
DO  - 10.11607/prd.2087
ER  - 

@article{
author = "Perunović, Neda and Rakić, Mia and Janković, Saša and Aleksić, Zoran and Struillou, Xavier and Čakić, Saša and Puletić, Miljan and Leković, Vojislav and Milašin, Jelena",
year = "2015",
abstract = "The objective of this pilot study was to investigate the potential role of-1562 C>T single nucleotide polymorphism (SNP) in the promoter region of the matrix metalloproteinase-9 (MMP-9) gene as a risk modulator in the development of multiple gingival recessions (MGRs) in young adults in the Serbian population. The study sample comprised 161 systemically healthy people: 60 with MGRs and 101 controls with healthy periodontal tissues. Genotyping was done using polymerase chain reaction/restriction fragment length polymorphism approach on DNA obtained from buccal swabs. Clinical measurements included vertical recession depth (VRD), clinical attachment level (CAL), keratinized gingival width (KGW), visible plaque index (PI), and bleeding on probing (BOP). Heterozygotes (CT) were significantly more frequent in the MGRs group than in the control group (P = .005) and carriers of the T allele had an approximately threefold increase of MGRs risk. Patients with the CT genotype exhibited significantly higher values of VRD and CAL and significantly lower values of KGW than patients with the wildtype genotype. Associations among different genotypes and periodontal biotypes in the MGRs group remained insignificant because all participants exhibited thin biotype. The 1562 C>T SNP in the promoter region of MMP-9 appears to be a risk factor for MGR development and a potential predictor of more severe clinical phenotype.",
publisher = "Quintessence Publishing Co. Inc.",
journal = "International Journal of Periodontics & Restorative Dentistry",
title = "MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions",
volume = "35",
number = "2",
pages = "263-269",
doi = "10.11607/prd.2087"
}

Perunović, N., Rakić, M., Janković, S., Aleksić, Z., Struillou, X., Čakić, S., Puletić, M., Leković, V.,& Milašin, J.. (2015). MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions. in International Journal of Periodontics & Restorative Dentistry
Quintessence Publishing Co. Inc.., 35(2), 263-269.
https://doi.org/10.11607/prd.2087

Perunović N, Rakić M, Janković S, Aleksić Z, Struillou X, Čakić S, Puletić M, Leković V, Milašin J. MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions. in International Journal of Periodontics & Restorative Dentistry. 2015;35(2):263-269.
doi:10.11607/prd.2087 .

Perunović, Neda, Rakić, Mia, Janković, Saša, Aleksić, Zoran, Struillou, Xavier, Čakić, Saša, Puletić, Miljan, Leković, Vojislav, Milašin, Jelena, "MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions" in International Journal of Periodontics & Restorative Dentistry, 35, no. 2 (2015):263-269,
https://doi.org/10.11607/prd.2087 . .

TY  - JOUR
AU  - Rakić, Mia
AU  - Leković, Vojislav
AU  - Nikolić-Jakoba, Nataša
AU  - Vojvodić, Danilo
AU  - Petković-Ćurčin, Aleksandra
AU  - Sanz, Mariano
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1824
AB  - Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Bone loss biomarkers associated with peri-implantitis. A cross-sectional study
VL  - 24
IS  - 10
SP  - 1110
EP  - 1116
DO  - 10.1111/j.1600-0501.2012.02518.x
ER  - 

@article{
author = "Rakić, Mia and Leković, Vojislav and Nikolić-Jakoba, Nataša and Vojvodić, Danilo and Petković-Ćurčin, Aleksandra and Sanz, Mariano",
year = "2013",
abstract = "Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Bone loss biomarkers associated with peri-implantitis. A cross-sectional study",
volume = "24",
number = "10",
pages = "1110-1116",
doi = "10.1111/j.1600-0501.2012.02518.x"
}

Rakić, M., Leković, V., Nikolić-Jakoba, N., Vojvodić, D., Petković-Ćurčin, A.,& Sanz, M.. (2013). Bone loss biomarkers associated with peri-implantitis. A cross-sectional study. in Clinical Oral Implants Research
Wiley, Hoboken., 24(10), 1110-1116.
https://doi.org/10.1111/j.1600-0501.2012.02518.x

Rakić M, Leković V, Nikolić-Jakoba N, Vojvodić D, Petković-Ćurčin A, Sanz M. Bone loss biomarkers associated with peri-implantitis. A cross-sectional study. in Clinical Oral Implants Research. 2013;24(10):1110-1116.
doi:10.1111/j.1600-0501.2012.02518.x .

Rakić, Mia, Leković, Vojislav, Nikolić-Jakoba, Nataša, Vojvodić, Danilo, Petković-Ćurčin, Aleksandra, Sanz, Mariano, "Bone loss biomarkers associated with peri-implantitis. A cross-sectional study" in Clinical Oral Implants Research, 24, no. 10 (2013):1110-1116,
https://doi.org/10.1111/j.1600-0501.2012.02518.x . .

TY  - JOUR
AU  - Rakić, Mia
AU  - Nikolić-Jakoba, Nataša
AU  - Struillou, Xavier
AU  - Petković-Ćurčin, Aleksandra
AU  - Stamatović, Novak
AU  - Matić, Smiljka
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Vasilić, Đurđa
AU  - Leković, Vojislav
AU  - Vojvodić, Danilo
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1778
AB  - Background/Aim. Peri-implantitis presents inflammatory process that affects soft and hard supporting tissues of osseointegrated implant based on inflammatory osteoclastogenesis. The aim of this study was to investigate whether receptor activator of nuclear factor kappa B (RANK) concentrations in peri-implant crevicular fluid could be associated with clinical parameters that reflect inflammatory nature of peri-implantitis. Methods. The study included 67 patients, 22 with diagnosed peri-implantitis, 22 persons with healthy peri-implant tissues and 23 patients with periodontitis. Clinical parameters from each patient were recorded and samples of peri-implant/gingival crevicular fluid were collected for the enzyme-linked immunosorbent assay (ELISA) analysis. Results. RANK concentration was significantly increased in samples from the patients with periimplantitis when compared to healthy implants (p  lt  0.0001), where the average levels were 9 times higher. At the same time RANK concentration was significantly higher in periimplantitis than in periodontitis sites (p  lt  0.0001). In implant patients pocket depths and bleeding on probing values were positively associated with high RANK concentrations (p  lt  0.0001). Conclusion. These results revealed association of increased RANK concentration in samples of periimplant/ gingival crevicular fluid with peri-implant inflammation and suggests that RANK could be a pathologic determinant of peri-implantitis, thereby a potential parameter in assessment of peri-implant tissue inflammation and a potential target in designing treatment strategies.
AB  - Uvod/Cilj. Periimplantitis predstavlja inflamatorni proces koji zahvata meko i tvrdo potporno tkivo osteointegrisanog implantata, i zasnovan je na inflamatornoj osteoklastogenezi. Cilj studije bio je da se utvrdi povezanost koncentracije receptora aktivatora nuklearnog faktora kapa-B (RANK), kao glavnog receptora osteoklastnog metabolizma, sa kliničkim parametrima periimplantitisa. Metode. Studija je uključila 67 sistemski zdravih pacijenata (22 sa periimplantitisom, 22 sa zdravim implantatima i 23 sa periodontopatijom). Pacijentima su mereni klinički parametri i uziman je uzorak periimplantne/gingivalne tečnosti za određivanje koncentracije RANK-a ELISA metodom. Rezultati. Koncentracija RANK-a bila je značajno povišena kod periimplantitisa u odnosu na zdrave implantate (p  lt  0,0001), gde je srednja vrednost koncentracije bila 9 puta veća. Istovremeno, RANK je bio značajno viši kod periimplantitisa nego kod parodontopatije (p  lt  0,0001). U grupi sa implantatima dubina periodontalnog džepa i krvarenje na probu bili su pozitivno udruženi sa visokim vrednostima RANK-a (p  lt  0,0001). Zaključak. Rezultati istraživanja pokazuju udruženost povišenosti koncentracije RANK-a sa periimplantnom inflamacijom i navodi na zaključak da bi RANK mogao da bude patološka determinanta periimplantitisa, a time i potencijalni parametar za praćenje inflamacije periimplantnog tkiva i potencijalni cilj za pravljenje terapijskih strategija.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis
T1  - Receptor aktivatora nuklearnog faktora kapa B kao činilac periimplantitisa
VL  - 70
IS  - 4
SP  - 346
EP  - 351
DO  - 10.2298/VSP1304346R
ER  - 

@article{
author = "Rakić, Mia and Nikolić-Jakoba, Nataša and Struillou, Xavier and Petković-Ćurčin, Aleksandra and Stamatović, Novak and Matić, Smiljka and Janković, Saša and Aleksić, Zoran and Vasilić, Đurđa and Leković, Vojislav and Vojvodić, Danilo",
year = "2013",
abstract = "Background/Aim. Peri-implantitis presents inflammatory process that affects soft and hard supporting tissues of osseointegrated implant based on inflammatory osteoclastogenesis. The aim of this study was to investigate whether receptor activator of nuclear factor kappa B (RANK) concentrations in peri-implant crevicular fluid could be associated with clinical parameters that reflect inflammatory nature of peri-implantitis. Methods. The study included 67 patients, 22 with diagnosed peri-implantitis, 22 persons with healthy peri-implant tissues and 23 patients with periodontitis. Clinical parameters from each patient were recorded and samples of peri-implant/gingival crevicular fluid were collected for the enzyme-linked immunosorbent assay (ELISA) analysis. Results. RANK concentration was significantly increased in samples from the patients with periimplantitis when compared to healthy implants (p  lt  0.0001), where the average levels were 9 times higher. At the same time RANK concentration was significantly higher in periimplantitis than in periodontitis sites (p  lt  0.0001). In implant patients pocket depths and bleeding on probing values were positively associated with high RANK concentrations (p  lt  0.0001). Conclusion. These results revealed association of increased RANK concentration in samples of periimplant/ gingival crevicular fluid with peri-implant inflammation and suggests that RANK could be a pathologic determinant of peri-implantitis, thereby a potential parameter in assessment of peri-implant tissue inflammation and a potential target in designing treatment strategies., Uvod/Cilj. Periimplantitis predstavlja inflamatorni proces koji zahvata meko i tvrdo potporno tkivo osteointegrisanog implantata, i zasnovan je na inflamatornoj osteoklastogenezi. Cilj studije bio je da se utvrdi povezanost koncentracije receptora aktivatora nuklearnog faktora kapa-B (RANK), kao glavnog receptora osteoklastnog metabolizma, sa kliničkim parametrima periimplantitisa. Metode. Studija je uključila 67 sistemski zdravih pacijenata (22 sa periimplantitisom, 22 sa zdravim implantatima i 23 sa periodontopatijom). Pacijentima su mereni klinički parametri i uziman je uzorak periimplantne/gingivalne tečnosti za određivanje koncentracije RANK-a ELISA metodom. Rezultati. Koncentracija RANK-a bila je značajno povišena kod periimplantitisa u odnosu na zdrave implantate (p  lt  0,0001), gde je srednja vrednost koncentracije bila 9 puta veća. Istovremeno, RANK je bio značajno viši kod periimplantitisa nego kod parodontopatije (p  lt  0,0001). U grupi sa implantatima dubina periodontalnog džepa i krvarenje na probu bili su pozitivno udruženi sa visokim vrednostima RANK-a (p  lt  0,0001). Zaključak. Rezultati istraživanja pokazuju udruženost povišenosti koncentracije RANK-a sa periimplantnom inflamacijom i navodi na zaključak da bi RANK mogao da bude patološka determinanta periimplantitisa, a time i potencijalni parametar za praćenje inflamacije periimplantnog tkiva i potencijalni cilj za pravljenje terapijskih strategija.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis, Receptor aktivatora nuklearnog faktora kapa B kao činilac periimplantitisa",
volume = "70",
number = "4",
pages = "346-351",
doi = "10.2298/VSP1304346R"
}

Rakić, M., Nikolić-Jakoba, N., Struillou, X., Petković-Ćurčin, A., Stamatović, N., Matić, S., Janković, S., Aleksić, Z., Vasilić, Đ., Leković, V.,& Vojvodić, D.. (2013). Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 70(4), 346-351.
https://doi.org/10.2298/VSP1304346R

Rakić M, Nikolić-Jakoba N, Struillou X, Petković-Ćurčin A, Stamatović N, Matić S, Janković S, Aleksić Z, Vasilić Đ, Leković V, Vojvodić D. Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis. in Vojnosanitetski pregled. 2013;70(4):346-351.
doi:10.2298/VSP1304346R .

Rakić, Mia, Nikolić-Jakoba, Nataša, Struillou, Xavier, Petković-Ćurčin, Aleksandra, Stamatović, Novak, Matić, Smiljka, Janković, Saša, Aleksić, Zoran, Vasilić, Đurđa, Leković, Vojislav, Vojvodić, Danilo, "Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis" in Vojnosanitetski pregled, 70, no. 4 (2013):346-351,
https://doi.org/10.2298/VSP1304346R . .

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Dimitrijević, Božidar
AU  - Camargo, Paulo
AU  - Kenney, Barrie
AU  - Leković, Vojislav
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1844
AB  - Risk factors such as smoking, genetic factors, and tissue biotype play an important role in the etiology, predictability, and long-term stability of gingival recession treatment. This study was designed to evaluate the influence of interleukin 1 (IL-1) polymorphism and smoking on the stability of gingival recession treatment after 1 and 3 years. All patients (n = 55) were treated for type I and II recession defects using a connective tissue graft. Clinical evaluations were performed, which included assessment of vertical recession depth, gingival inflammation, and clinical attachment level. A fingerstick blood sample was collected using specially provided DNA filter paper and mailed for processing in a laboratory using polymerase chain reaction-based methodology. The results indicated that 19 subjects were genotype positive (34.5%). Treatment of the localized recessions was effective and provided a similar amount of coverage in genotype-positive and genotype-negative subjects within smoking and nonsmoking groups after 1 year. In a 3-year period, nonsmoking patients with positive IL-1 genotype lost approximately 20% of the root coverage gained at 1 year and were almost four times more inferior compared with genotype-negative patients. Patients who smoked and had a positive IL-1 genotype lost approximately 35% of the gained root coverage. IL-1 polymorphism and smoking habit did not affect gingival recession treatment at 1 year but had a great impact on long-term stability.
PB  - Quintessence Publishing Co Inc, Hanover Park
T2  - International Journal of Periodontics & Restorative Dentistry
T1  - Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment
VL  - 33
IS  - 1
SP  - E16
EP  - E23
DO  - 10.11607/prd.0823
ER  - 

@article{
author = "Janković, Saša and Aleksić, Zoran and Dimitrijević, Božidar and Camargo, Paulo and Kenney, Barrie and Leković, Vojislav",
year = "2013",
abstract = "Risk factors such as smoking, genetic factors, and tissue biotype play an important role in the etiology, predictability, and long-term stability of gingival recession treatment. This study was designed to evaluate the influence of interleukin 1 (IL-1) polymorphism and smoking on the stability of gingival recession treatment after 1 and 3 years. All patients (n = 55) were treated for type I and II recession defects using a connective tissue graft. Clinical evaluations were performed, which included assessment of vertical recession depth, gingival inflammation, and clinical attachment level. A fingerstick blood sample was collected using specially provided DNA filter paper and mailed for processing in a laboratory using polymerase chain reaction-based methodology. The results indicated that 19 subjects were genotype positive (34.5%). Treatment of the localized recessions was effective and provided a similar amount of coverage in genotype-positive and genotype-negative subjects within smoking and nonsmoking groups after 1 year. In a 3-year period, nonsmoking patients with positive IL-1 genotype lost approximately 20% of the root coverage gained at 1 year and were almost four times more inferior compared with genotype-negative patients. Patients who smoked and had a positive IL-1 genotype lost approximately 35% of the gained root coverage. IL-1 polymorphism and smoking habit did not affect gingival recession treatment at 1 year but had a great impact on long-term stability.",
publisher = "Quintessence Publishing Co Inc, Hanover Park",
journal = "International Journal of Periodontics & Restorative Dentistry",
title = "Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment",
volume = "33",
number = "1",
pages = "E16-E23",
doi = "10.11607/prd.0823"
}

Janković, S., Aleksić, Z., Dimitrijević, B., Camargo, P., Kenney, B.,& Leković, V.. (2013). Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment. in International Journal of Periodontics & Restorative Dentistry
Quintessence Publishing Co Inc, Hanover Park., 33(1), E16-E23.
https://doi.org/10.11607/prd.0823

Janković S, Aleksić Z, Dimitrijević B, Camargo P, Kenney B, Leković V. Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment. in International Journal of Periodontics & Restorative Dentistry. 2013;33(1):E16-E23.
doi:10.11607/prd.0823 .

Janković, Saša, Aleksić, Zoran, Dimitrijević, Božidar, Camargo, Paulo, Kenney, Barrie, Leković, Vojislav, "Impact of Interleukin 1 Gene Polymorphism and Smoking on Long-Term Stability Following Gingival Recession Treatment" in International Journal of Periodontics & Restorative Dentistry, 33, no. 1 (2013):E16-E23,
https://doi.org/10.11607/prd.0823 . .

TY  - JOUR
AU  - Nikolić-Jakoba, Nataša
AU  - Vojnović, Sandra
AU  - Pavić, A.
AU  - Janković, Saša
AU  - Leković, Vojislav
AU  - Vasiljević, Branka
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1696
AB  - Aggregatibacter actinomycetemcomitans is considered one of the bacterial species of etiological importance in periodontitis. The aim of this study was to evaluate the serotype of A. actinomycetemcomitans in the subgingival biofilm in subjects with periodontal health and disease. Pooled samples of subgingival plaque were taken for culture-based identification of microorganisms. Colonies suspected to be A. actinomycetemcomitans were selected for molecular identification using either multiplex or conventional PCR in serotype-specific genotyping and 16S rRNA gene sequencing. In silico analysis showed that most selected colonies belong to the genus Campylobacter, although positive signals for serotypes of A. actinomycetemcomitans were obtained with these samples. Identification of A. actinomycetemcomitans by conventional PCR for 16S rRNA with one species-specific and one universal primer was inconclusive because an almost identical signal with Campylobacter gracilis was obtained. Although PCR-based methods for the identification of A. actinomycetemcomitans are more rapid, sequencing should not be omitted.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Polymerase chain reaction in the identification of periodontopathogens: A reliable and satisfactory method?
VL  - 64
IS  - 4
SP  - 1413
EP  - 1423
DO  - 10.2298/ABS1204413J
ER  - 

@article{
author = "Nikolić-Jakoba, Nataša and Vojnović, Sandra and Pavić, A. and Janković, Saša and Leković, Vojislav and Vasiljević, Branka",
year = "2012",
abstract = "Aggregatibacter actinomycetemcomitans is considered one of the bacterial species of etiological importance in periodontitis. The aim of this study was to evaluate the serotype of A. actinomycetemcomitans in the subgingival biofilm in subjects with periodontal health and disease. Pooled samples of subgingival plaque were taken for culture-based identification of microorganisms. Colonies suspected to be A. actinomycetemcomitans were selected for molecular identification using either multiplex or conventional PCR in serotype-specific genotyping and 16S rRNA gene sequencing. In silico analysis showed that most selected colonies belong to the genus Campylobacter, although positive signals for serotypes of A. actinomycetemcomitans were obtained with these samples. Identification of A. actinomycetemcomitans by conventional PCR for 16S rRNA with one species-specific and one universal primer was inconclusive because an almost identical signal with Campylobacter gracilis was obtained. Although PCR-based methods for the identification of A. actinomycetemcomitans are more rapid, sequencing should not be omitted.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Polymerase chain reaction in the identification of periodontopathogens: A reliable and satisfactory method?",
volume = "64",
number = "4",
pages = "1413-1423",
doi = "10.2298/ABS1204413J"
}

Nikolić-Jakoba, N., Vojnović, S., Pavić, A., Janković, S., Leković, V.,& Vasiljević, B.. (2012). Polymerase chain reaction in the identification of periodontopathogens: A reliable and satisfactory method?. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 64(4), 1413-1423.
https://doi.org/10.2298/ABS1204413J

Nikolić-Jakoba N, Vojnović S, Pavić A, Janković S, Leković V, Vasiljević B. Polymerase chain reaction in the identification of periodontopathogens: A reliable and satisfactory method?. in Archives of Biological Sciences. 2012;64(4):1413-1423.
doi:10.2298/ABS1204413J .

Nikolić-Jakoba, Nataša, Vojnović, Sandra, Pavić, A., Janković, Saša, Leković, Vojislav, Vasiljević, Branka, "Polymerase chain reaction in the identification of periodontopathogens: A reliable and satisfactory method?" in Archives of Biological Sciences, 64, no. 4 (2012):1413-1423,
https://doi.org/10.2298/ABS1204413J . .

TY  - JOUR
AU  - Petrović, Vanja
AU  - Pejčić, Nataša
AU  - Rakić, Mia
AU  - Leković, Vojislav
AU  - Vasić, Una
AU  - Stojić, Ž.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1707
AB  - Platelet-reach plasma (PRP) is an attractive tool in regenerative medicine due to its ability to stimulate proliferation and differentiation of stem cells. Since dental pulp derived stem cells are recognized as central in apexogenesis, the aim of the study was to evaluate radiologically and histologically effects of PRP on apexogenesis in teeth with immature roots. The study included eight monkeys (Cercopithecus Aethiops) divided in two equal groups for evaluation 3 and 12 months after treatment. All participants obtained the same treatment including pulpotomy and after-treatment with: hydroxiapatite (HA)-incisor and HA+canine PRP. Radiological evaluation was performed using the long cone paralleling technique for recording of defined parameters and histological evaluation was performed using tissue removed en block for the observation of parameters related to apexogenesis. The results obtained radiologically and histologically have shown increase in bridge formation in HA+PRP (75%) group after 3 months comparing to HA group (50%). Contrary to that, after 12 months there were no significant differences between groups. The root delay was not registered in the HA+PRP group contrary to HA group where it was registered in 25% after 12 months. Results of the study suggest that PRP is a powerful tool for intensive and rapid apexogenesis since it offers clear and comprehensive results (mostly in the first three months) which are early radiologically visible without any failure in the proposed requests.
AB  - Primena plazme bogate trombocitima (PRP) predstavlja atraktivnu metodu u savremenoj regenerativnoj medicini zbog toga što ona ima sposobnost da stimuliš e proliferaciju i diferencijaciju stem ćelija. Kako su stem ćelije poreklom od dentalne pulpe definisane kao glavne u procesu apeksogeneze, cilj ove studije je bio da radiološki i histološki evaluira efekat PRP na apeksogenezu zuba sa nedovrš enim rastom korena. Studija je obuhvatila 8 majmuna (Cercopithecus Aethiops) koji su bili podeljeni u dve jednake grupe za evaluiranje, 3 i 12 meseci nakon terapije. Sve životinje su bile podvrgnute istom tretmanu uključujući pulpotomiju i tretman: hidroksiapatitom (HA) - sekutići i HA+PRP - očnjaci. Radiološka evaluacija je urađena određivanjem zadatih parametara na radiogramima dobijenim paralelnom tehnikom dugog konusa, a histološka analiza je sprovedena analiziranjem parametara svojstvenih apeksogenezi u preparatima uzetim 'en blok' tehnikom. Dobijeni rezultati su radiološki i histološki za dentinski most posle 3 meseca ukazali na porast u grupi HA+PRP (75%) u poređenju sa HA grupom (50%). Nasuprot tome, posle 12 meseci nije bilo razlike među grupama. Zaostatak u razvoju korena nije utvrđen u HA+PRP grupi za razliku od HA grupe gde je utvrđen zaostatak u 25% slučajeva. Rezultati studije navode na zaključak da je PRP moćno sredstvo za brzu i intezivnu apeksogenezu zbog toga što daje jasne i sveobuhvatne rezultate (najviše u prva tri meseca), koji su radiološki rano vidljivi.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation
T1  - Efekti plazme bogate trombocitima na apeksogenezu kod mladih majmuna - radiološka i histološka evaluacija
VL  - 62
IS  - 1
SP  - 39
EP  - 52
DO  - 10.2298/AVB1201039P
ER  - 

@article{
author = "Petrović, Vanja and Pejčić, Nataša and Rakić, Mia and Leković, Vojislav and Vasić, Una and Stojić, Ž.",
year = "2012",
abstract = "Platelet-reach plasma (PRP) is an attractive tool in regenerative medicine due to its ability to stimulate proliferation and differentiation of stem cells. Since dental pulp derived stem cells are recognized as central in apexogenesis, the aim of the study was to evaluate radiologically and histologically effects of PRP on apexogenesis in teeth with immature roots. The study included eight monkeys (Cercopithecus Aethiops) divided in two equal groups for evaluation 3 and 12 months after treatment. All participants obtained the same treatment including pulpotomy and after-treatment with: hydroxiapatite (HA)-incisor and HA+canine PRP. Radiological evaluation was performed using the long cone paralleling technique for recording of defined parameters and histological evaluation was performed using tissue removed en block for the observation of parameters related to apexogenesis. The results obtained radiologically and histologically have shown increase in bridge formation in HA+PRP (75%) group after 3 months comparing to HA group (50%). Contrary to that, after 12 months there were no significant differences between groups. The root delay was not registered in the HA+PRP group contrary to HA group where it was registered in 25% after 12 months. Results of the study suggest that PRP is a powerful tool for intensive and rapid apexogenesis since it offers clear and comprehensive results (mostly in the first three months) which are early radiologically visible without any failure in the proposed requests., Primena plazme bogate trombocitima (PRP) predstavlja atraktivnu metodu u savremenoj regenerativnoj medicini zbog toga što ona ima sposobnost da stimuliš e proliferaciju i diferencijaciju stem ćelija. Kako su stem ćelije poreklom od dentalne pulpe definisane kao glavne u procesu apeksogeneze, cilj ove studije je bio da radiološki i histološki evaluira efekat PRP na apeksogenezu zuba sa nedovrš enim rastom korena. Studija je obuhvatila 8 majmuna (Cercopithecus Aethiops) koji su bili podeljeni u dve jednake grupe za evaluiranje, 3 i 12 meseci nakon terapije. Sve životinje su bile podvrgnute istom tretmanu uključujući pulpotomiju i tretman: hidroksiapatitom (HA) - sekutići i HA+PRP - očnjaci. Radiološka evaluacija je urađena određivanjem zadatih parametara na radiogramima dobijenim paralelnom tehnikom dugog konusa, a histološka analiza je sprovedena analiziranjem parametara svojstvenih apeksogenezi u preparatima uzetim 'en blok' tehnikom. Dobijeni rezultati su radiološki i histološki za dentinski most posle 3 meseca ukazali na porast u grupi HA+PRP (75%) u poređenju sa HA grupom (50%). Nasuprot tome, posle 12 meseci nije bilo razlike među grupama. Zaostatak u razvoju korena nije utvrđen u HA+PRP grupi za razliku od HA grupe gde je utvrđen zaostatak u 25% slučajeva. Rezultati studije navode na zaključak da je PRP moćno sredstvo za brzu i intezivnu apeksogenezu zbog toga što daje jasne i sveobuhvatne rezultate (najviše u prva tri meseca), koji su radiološki rano vidljivi.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation, Efekti plazme bogate trombocitima na apeksogenezu kod mladih majmuna - radiološka i histološka evaluacija",
volume = "62",
number = "1",
pages = "39-52",
doi = "10.2298/AVB1201039P"
}

Petrović, V., Pejčić, N., Rakić, M., Leković, V., Vasić, U.,& Stojić, Ž.. (2012). Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 62(1), 39-52.
https://doi.org/10.2298/AVB1201039P

Petrović V, Pejčić N, Rakić M, Leković V, Vasić U, Stojić Ž. Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation. in Acta veterinaria. 2012;62(1):39-52.
doi:10.2298/AVB1201039P .

Petrović, Vanja, Pejčić, Nataša, Rakić, Mia, Leković, Vojislav, Vasić, Una, Stojić, Ž., "Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation" in Acta veterinaria, 62, no. 1 (2012):39-52,
https://doi.org/10.2298/AVB1201039P . .

TY  - JOUR
AU  - Leković, Vojislav
AU  - Milinković, Iva
AU  - Aleksić, Zoran
AU  - Janković, Saša
AU  - Stanković, P.
AU  - Kenney, Barrie
AU  - Camargo, Paulo
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1762
AB  - Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, Camargo PM. Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodont Res 2012; 47: 409417. (c) 2011 John Wiley & Sons A/S Background and Objective: Bovine porous bone mineral (BPBM) is a xenograft that has been successfully utilized in periodontal regeneration. Platelet-rich fibrin (PRF) is a leukocyte and platelet preparation that concentrates various polypeptide growth factors and therefore has the potential to be used as regenerative treatment for periodontal defects. The purpose of this study was to examine the suitability of autologous PRF as regenerative treatment for periodontal intrabony defects in humans and to examine the ability of BPBM to augment the regenerative effects exerted by PRF. Material and Methods: Using a split-mouth design, 17 paired intrabony defects were randomly treated either with PRF or with PRFBPBM combination. Re-entry surgeries were performed at 6 mo. Primary study outcomes were changes in pocket depth, attachment level and defect fill. Results: Preoperative pocket depths, attachment levels and transoperative bone measurements were similar for the PRF and PRFBPBM groups. Postsurgical measurements revealed a significantly greater reduction in pocket depth in the PRFBPBM group (4.47 +/- 0.78 mm on buccal and 4.29 +/- 0.82 mm on lingual sites) when compared with the PRF group (3.35 +/- 0.68 mm on buccal and 3.24 +/- 0.73 mm on lingual sites). The PRFBPBM group presented with significantly greater attachment gain (3.82 +/- 0.78 mm on buccal and 3.71 +/- 0.75 mm on lingual sites) than the PRF group (2.24 +/- 0.73 mm on buccal and 2.12 +/- 0.68 mm on lingual sites). Defect fill was also greater in the PRFBPBM group (4.06 +/- 0.87 mm on buccal and 3.94 +/- 0.73 mm on lingual sites) than in the PRF group (2.21 +/- 0.68 mm on buccal and 2.06 +/- 0.64 mm on lingual sites). Conclusion: The results of this study indicate that PRF can improve clinical parameters associated with human intrabony periodontal defects, and BPBM has the ability to augment the effects of PRF in reducing pocket depth, improving clinical attachment levels and promoting defect fill.
PB  - Wiley, Hoboken
T2  - Journal of Periodontal Research
T1  - Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects
VL  - 47
IS  - 4
SP  - 409
EP  - 417
DO  - 10.1111/j.1600-0765.2011.01446.x
ER  - 

@article{
author = "Leković, Vojislav and Milinković, Iva and Aleksić, Zoran and Janković, Saša and Stanković, P. and Kenney, Barrie and Camargo, Paulo",
year = "2012",
abstract = "Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, Camargo PM. Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodont Res 2012; 47: 409417. (c) 2011 John Wiley & Sons A/S Background and Objective: Bovine porous bone mineral (BPBM) is a xenograft that has been successfully utilized in periodontal regeneration. Platelet-rich fibrin (PRF) is a leukocyte and platelet preparation that concentrates various polypeptide growth factors and therefore has the potential to be used as regenerative treatment for periodontal defects. The purpose of this study was to examine the suitability of autologous PRF as regenerative treatment for periodontal intrabony defects in humans and to examine the ability of BPBM to augment the regenerative effects exerted by PRF. Material and Methods: Using a split-mouth design, 17 paired intrabony defects were randomly treated either with PRF or with PRFBPBM combination. Re-entry surgeries were performed at 6 mo. Primary study outcomes were changes in pocket depth, attachment level and defect fill. Results: Preoperative pocket depths, attachment levels and transoperative bone measurements were similar for the PRF and PRFBPBM groups. Postsurgical measurements revealed a significantly greater reduction in pocket depth in the PRFBPBM group (4.47 +/- 0.78 mm on buccal and 4.29 +/- 0.82 mm on lingual sites) when compared with the PRF group (3.35 +/- 0.68 mm on buccal and 3.24 +/- 0.73 mm on lingual sites). The PRFBPBM group presented with significantly greater attachment gain (3.82 +/- 0.78 mm on buccal and 3.71 +/- 0.75 mm on lingual sites) than the PRF group (2.24 +/- 0.73 mm on buccal and 2.12 +/- 0.68 mm on lingual sites). Defect fill was also greater in the PRFBPBM group (4.06 +/- 0.87 mm on buccal and 3.94 +/- 0.73 mm on lingual sites) than in the PRF group (2.21 +/- 0.68 mm on buccal and 2.06 +/- 0.64 mm on lingual sites). Conclusion: The results of this study indicate that PRF can improve clinical parameters associated with human intrabony periodontal defects, and BPBM has the ability to augment the effects of PRF in reducing pocket depth, improving clinical attachment levels and promoting defect fill.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontal Research",
title = "Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects",
volume = "47",
number = "4",
pages = "409-417",
doi = "10.1111/j.1600-0765.2011.01446.x"
}

Leković, V., Milinković, I., Aleksić, Z., Janković, S., Stanković, P., Kenney, B.,& Camargo, P.. (2012). Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. in Journal of Periodontal Research
Wiley, Hoboken., 47(4), 409-417.
https://doi.org/10.1111/j.1600-0765.2011.01446.x

Leković V, Milinković I, Aleksić Z, Janković S, Stanković P, Kenney B, Camargo P. Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. in Journal of Periodontal Research. 2012;47(4):409-417.
doi:10.1111/j.1600-0765.2011.01446.x .

Leković, Vojislav, Milinković, Iva, Aleksić, Zoran, Janković, Saša, Stanković, P., Kenney, Barrie, Camargo, Paulo, "Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects" in Journal of Periodontal Research, 47, no. 4 (2012):409-417,
https://doi.org/10.1111/j.1600-0765.2011.01446.x . .

TY  - JOUR
AU  - Špadijer-Gostović, Aleksandra
AU  - Todorović, Aleksandar
AU  - Lazić, Vojkan
AU  - Todorović, Ana
AU  - Milinković, Iva
AU  - Leković, Vojislav
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1716
AB  - Background/Aim. Immediate loading is considered to be the most innovative technique in contemporary implant dentistry. Recent clinical and experimental findings have demonstrated that only implants with high primary stability can be subjected to immediate loading protocol with predictable results. It is generally accepted that the most important prerequsite for successful osseointegration is achievement and maintenance of implant stability. The aim of this in vivo study was to investigate the possibility for successful application of immediate loading protocol in implant systems with different surface properties. Methods. In the experimental study 2 mongrel dogs were edentulated bilaterally in the mandibular and maxillary premolar areas. After 3 months implants were placed in a pattern 4 different commercially available implants per quadrant (n = 32): Mk III TiUnite (Nobel Biocare, Sweden), ITI TPS (Straumann, Switzerland), 3IOsseotite (Implant Innovation, USA) and XiVE Cell-Plus (Friadent, Germany). Implants were subjected to immediate loading with 4 unit gold cast bridges, 2 days post implantation. The assessment of implant stability and immediate loading possibilities were done by performing Resonance frequency analysis (RFA). Results. After a 6- month loading period all bridges were in function and all implants occurred well osseointegrated. When summarizing the Implant Stability Quotient (ISQ) values, it was noted that resonance frequency was significantly higher for mandibular implants. The results of this experimental setting showed that all evaluated surfaces achieved good implant stability. Increase of ISQ values was found for all implants in the mandible and partially decrease of ISQ values for maxillary implants after 6 months of functional loading with 4 unit bridges. Conclusions. Investigated endooseal implants did not show different degree of osseointegration, because there was not statistically significant difference among observed parameters (ISQh i ISQp) between implant systems.
AB  - Uvod/Cilj. Imedijatno opterećenje implantata smatra se jednim od najznačajnijih dostignuća savremene dentalne implantologije. Rezultati novijih kliničkih i eksperimentalnih studija pokazali su da samo implantati visoke primarne stabilnosti mogu biti izloženi protokolu imedijatnog opterećenja zubnom nadoknadom sa predvidivim ishodom. Cilj studije bio je da se ispita mogućnost uspešne primene protokola imedijatnog opterećenja implantata različitog mikrodizajna fiksnim zubnim nadoknadama. Metode. U eksperimentalno istraživanje uključena su dva psa, obezubljena obostrano u premolarnoj regiji gornje i donje vilice. Nakon tri meseca od ekstrakcije zuba, ugrađena su, po predviđenoj šemi, četiri različita implantata po kvadrantu (n = 32): Mk III TiUnite (Nobel Biocare, Sweden), ITI TPS (Straumann, Switzerland), 3I-Osseotite (Implant Innovation, USA) i XiVE Cell-Plus (Friadent, Germany). Implantati su imedijatno opterećeni fiksnim zubnim nadoknadama, četvoročlanim mostovima od plemenite legure zlato-platina, dva dana posle implantacije. Stabilnost implantata i mogućnost imedijatnog opterećenja ocenjivana je na osnovu analize rezonantnih frekvencija (RFA). Rezultati. Šest meseci nakon implantacije i imedijatnog opterećenja fiksnom zubnom nadoknadom, svi mostovi bili su u funkciji i svi implantati uspešno integrisani, ne pokazujući znake mobilnosti. Sumiranjem dobijenih vrednosti koeficijenta stabilnosti implantata (ISQ) ustanovljeno je da su rezonantne frekvencije bile značajno veće kod implantata u donjoj vilici. Rezultati eksperimentalnog istraživanja pokazali su da su sve analizirane površine ostvarile dobru implantatnu stabilnost. Utvrđen je porast ISQ vrednosti kod svih implantata u mandibuli i delimičan pad ISQ vrednosti za implantate u maksili, nakon šest meseci funkcionalnog opterećenja fiksnim zubnim nadoknadama. Zaključak. Ispitivani endoosealni implantati nisu pokazali različit stepen oseointegracije jer se rezultati merenih parametara hirurških (ISQh) i protetkih (ISQp), nisu statistički značajno razlikovali između implantatnih sistema.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Immediate implant loading with fixed dental restorations: An animal model study
T1  - Imedijatno opterećenje implantata fiksnim zubnim nadoknadama - studija na psima
VL  - 69
IS  - 2
SP  - 181
EP  - 189
DO  - 10.2298/VSP1202181S
ER  - 

@article{
author = "Špadijer-Gostović, Aleksandra and Todorović, Aleksandar and Lazić, Vojkan and Todorović, Ana and Milinković, Iva and Leković, Vojislav",
year = "2012",
abstract = "Background/Aim. Immediate loading is considered to be the most innovative technique in contemporary implant dentistry. Recent clinical and experimental findings have demonstrated that only implants with high primary stability can be subjected to immediate loading protocol with predictable results. It is generally accepted that the most important prerequsite for successful osseointegration is achievement and maintenance of implant stability. The aim of this in vivo study was to investigate the possibility for successful application of immediate loading protocol in implant systems with different surface properties. Methods. In the experimental study 2 mongrel dogs were edentulated bilaterally in the mandibular and maxillary premolar areas. After 3 months implants were placed in a pattern 4 different commercially available implants per quadrant (n = 32): Mk III TiUnite (Nobel Biocare, Sweden), ITI TPS (Straumann, Switzerland), 3IOsseotite (Implant Innovation, USA) and XiVE Cell-Plus (Friadent, Germany). Implants were subjected to immediate loading with 4 unit gold cast bridges, 2 days post implantation. The assessment of implant stability and immediate loading possibilities were done by performing Resonance frequency analysis (RFA). Results. After a 6- month loading period all bridges were in function and all implants occurred well osseointegrated. When summarizing the Implant Stability Quotient (ISQ) values, it was noted that resonance frequency was significantly higher for mandibular implants. The results of this experimental setting showed that all evaluated surfaces achieved good implant stability. Increase of ISQ values was found for all implants in the mandible and partially decrease of ISQ values for maxillary implants after 6 months of functional loading with 4 unit bridges. Conclusions. Investigated endooseal implants did not show different degree of osseointegration, because there was not statistically significant difference among observed parameters (ISQh i ISQp) between implant systems., Uvod/Cilj. Imedijatno opterećenje implantata smatra se jednim od najznačajnijih dostignuća savremene dentalne implantologije. Rezultati novijih kliničkih i eksperimentalnih studija pokazali su da samo implantati visoke primarne stabilnosti mogu biti izloženi protokolu imedijatnog opterećenja zubnom nadoknadom sa predvidivim ishodom. Cilj studije bio je da se ispita mogućnost uspešne primene protokola imedijatnog opterećenja implantata različitog mikrodizajna fiksnim zubnim nadoknadama. Metode. U eksperimentalno istraživanje uključena su dva psa, obezubljena obostrano u premolarnoj regiji gornje i donje vilice. Nakon tri meseca od ekstrakcije zuba, ugrađena su, po predviđenoj šemi, četiri različita implantata po kvadrantu (n = 32): Mk III TiUnite (Nobel Biocare, Sweden), ITI TPS (Straumann, Switzerland), 3I-Osseotite (Implant Innovation, USA) i XiVE Cell-Plus (Friadent, Germany). Implantati su imedijatno opterećeni fiksnim zubnim nadoknadama, četvoročlanim mostovima od plemenite legure zlato-platina, dva dana posle implantacije. Stabilnost implantata i mogućnost imedijatnog opterećenja ocenjivana je na osnovu analize rezonantnih frekvencija (RFA). Rezultati. Šest meseci nakon implantacije i imedijatnog opterećenja fiksnom zubnom nadoknadom, svi mostovi bili su u funkciji i svi implantati uspešno integrisani, ne pokazujući znake mobilnosti. Sumiranjem dobijenih vrednosti koeficijenta stabilnosti implantata (ISQ) ustanovljeno je da su rezonantne frekvencije bile značajno veće kod implantata u donjoj vilici. Rezultati eksperimentalnog istraživanja pokazali su da su sve analizirane površine ostvarile dobru implantatnu stabilnost. Utvrđen je porast ISQ vrednosti kod svih implantata u mandibuli i delimičan pad ISQ vrednosti za implantate u maksili, nakon šest meseci funkcionalnog opterećenja fiksnim zubnim nadoknadama. Zaključak. Ispitivani endoosealni implantati nisu pokazali različit stepen oseointegracije jer se rezultati merenih parametara hirurških (ISQh) i protetkih (ISQp), nisu statistički značajno razlikovali između implantatnih sistema.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Immediate implant loading with fixed dental restorations: An animal model study, Imedijatno opterećenje implantata fiksnim zubnim nadoknadama - studija na psima",
volume = "69",
number = "2",
pages = "181-189",
doi = "10.2298/VSP1202181S"
}

Špadijer-Gostović, A., Todorović, A., Lazić, V., Todorović, A., Milinković, I.,& Leković, V.. (2012). Immediate implant loading with fixed dental restorations: An animal model study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 69(2), 181-189.
https://doi.org/10.2298/VSP1202181S

Špadijer-Gostović A, Todorović A, Lazić V, Todorović A, Milinković I, Leković V. Immediate implant loading with fixed dental restorations: An animal model study. in Vojnosanitetski pregled. 2012;69(2):181-189.
doi:10.2298/VSP1202181S .

Špadijer-Gostović, Aleksandra, Todorović, Aleksandar, Lazić, Vojkan, Todorović, Ana, Milinković, Iva, Leković, Vojislav, "Immediate implant loading with fixed dental restorations: An animal model study" in Vojnosanitetski pregled, 69, no. 2 (2012):181-189,
https://doi.org/10.2298/VSP1202181S . .

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Klokkevold, Perry
AU  - Leković, Vojislav
AU  - Dimitrijević, Božidar
AU  - Kenney, Barrie
AU  - Camargo, Paulo
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1690
AB  - This 6-month randomized controlled clinical study primarily aimed to compare the results achieved by the use of a platelet-rich fibrin (PRF) membrane or connective tissue graft (CTG) in the treatment of gingival recession and to evaluate the clinical impact of PRF on early wound healing and subjective patient discomfort. Use of a PRF membrane in gingival recession treatment provided acceptable clinical results, followed by enhanced wound healing and decreased subjective patient discomfort compared to CTG-treated gingival recessions. No difference could be found between PRF and CTG procedures in gingival recession therapy, except for a greater gain in keratinized tissue width obtained in the CTG group and enhanced wound healing associated with the PRF group. (Int J Periodontics Restorative Dent 2012;32:e41-e50.)
T2  - International Journal of Periodontics & Restorative Dentistry
T1  - Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial
VL  - 32
IS  - 2
SP  - e41
EP  - e50
UR  - https://hdl.handle.net/21.15107/rcub_smile_1690
ER  - 

@article{
author = "Janković, Saša and Aleksić, Zoran and Klokkevold, Perry and Leković, Vojislav and Dimitrijević, Božidar and Kenney, Barrie and Camargo, Paulo",
year = "2012",
abstract = "This 6-month randomized controlled clinical study primarily aimed to compare the results achieved by the use of a platelet-rich fibrin (PRF) membrane or connective tissue graft (CTG) in the treatment of gingival recession and to evaluate the clinical impact of PRF on early wound healing and subjective patient discomfort. Use of a PRF membrane in gingival recession treatment provided acceptable clinical results, followed by enhanced wound healing and decreased subjective patient discomfort compared to CTG-treated gingival recessions. No difference could be found between PRF and CTG procedures in gingival recession therapy, except for a greater gain in keratinized tissue width obtained in the CTG group and enhanced wound healing associated with the PRF group. (Int J Periodontics Restorative Dent 2012;32:e41-e50.)",
journal = "International Journal of Periodontics & Restorative Dentistry",
title = "Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial",
volume = "32",
number = "2",
pages = "e41-e50",
url = "https://hdl.handle.net/21.15107/rcub_smile_1690"
}

Janković, S., Aleksić, Z., Klokkevold, P., Leković, V., Dimitrijević, B., Kenney, B.,& Camargo, P.. (2012). Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial. in International Journal of Periodontics & Restorative Dentistry, 32(2), e41-e50.
https://hdl.handle.net/21.15107/rcub_smile_1690

Janković S, Aleksić Z, Klokkevold P, Leković V, Dimitrijević B, Kenney B, Camargo P. Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial. in International Journal of Periodontics & Restorative Dentistry. 2012;32(2):e41-e50.
https://hdl.handle.net/21.15107/rcub_smile_1690 .

Janković, Saša, Aleksić, Zoran, Klokkevold, Perry, Leković, Vojislav, Dimitrijević, Božidar, Kenney, Barrie, Camargo, Paulo, "Use of Platelet-Rich Fibrin Membrane Following Treatment of Gingival Recession: A Randomized Clinical Trial" in International Journal of Periodontics & Restorative Dentistry, 32, no. 2 (2012):e41-e50,
https://hdl.handle.net/21.15107/rcub_smile_1690 .

TY  - JOUR
AU  - Igić, M.
AU  - Kesić, Ljiljana
AU  - Leković, Vojislav
AU  - Apostolović, Mirjana
AU  - Mihailović, D.
AU  - Kostadinović, Ljiljana
AU  - Milašin, Jelena
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1765
AB  - The purpose of this study was to determine the level of gingival inflammation and the prevalence of periodontopathogenic microorganisms in adolescents with chronic gingivitis, as well as to compare the effectiveness of two approaches in gingivitis treatment-basic therapy alone and basic therapy + adjunctive low-level laser therapy (LLLT). After periodontal evaluation, the content of gingival pockets of 140 adolescents with gingivitis was analyzed by multiplex PCR for the presence of P. gingivalis, A. actinomycetemcomitans, T. forsythensis and P. intermedia. Subsequent to bacteria detection, the examinees were divided into two groups with homogenous clinical and microbiological characteristics. Group A was subjected to basic gingivitis therapy, and group B underwent basic therapy along with adjunctive LLLT. A statistically significant difference between the values of plaque-index (PI) and sulcus bleeding index (SBI) before and after therapy was confirmed in both groups (p  lt  0.001), though more pronounced in group B. Following therapy, the incidence of periodontopathogenic microorganisms decreased considerably. The best result was obtained in P. gingivalis eradication by combined therapy (p = 0.003). The presence of periodontopathogens in adolescents with gingivitis should be regarded as a sign for dentists to foster more effective oral health programs. LLLT appears to be beneficial as adjuvant to basic therapy.
PB  - Springer, New York
T2  - European Journal of Clinical Microbiology & Infectious Diseases
T1  - Chronic gingivitis: the prevalence of periodontopathogens and therapy efficiency
VL  - 31
IS  - 8
SP  - 1911
EP  - 1915
DO  - 10.1007/s10096-011-1520-7
ER  - 

@article{
author = "Igić, M. and Kesić, Ljiljana and Leković, Vojislav and Apostolović, Mirjana and Mihailović, D. and Kostadinović, Ljiljana and Milašin, Jelena",
year = "2012",
abstract = "The purpose of this study was to determine the level of gingival inflammation and the prevalence of periodontopathogenic microorganisms in adolescents with chronic gingivitis, as well as to compare the effectiveness of two approaches in gingivitis treatment-basic therapy alone and basic therapy + adjunctive low-level laser therapy (LLLT). After periodontal evaluation, the content of gingival pockets of 140 adolescents with gingivitis was analyzed by multiplex PCR for the presence of P. gingivalis, A. actinomycetemcomitans, T. forsythensis and P. intermedia. Subsequent to bacteria detection, the examinees were divided into two groups with homogenous clinical and microbiological characteristics. Group A was subjected to basic gingivitis therapy, and group B underwent basic therapy along with adjunctive LLLT. A statistically significant difference between the values of plaque-index (PI) and sulcus bleeding index (SBI) before and after therapy was confirmed in both groups (p  lt  0.001), though more pronounced in group B. Following therapy, the incidence of periodontopathogenic microorganisms decreased considerably. The best result was obtained in P. gingivalis eradication by combined therapy (p = 0.003). The presence of periodontopathogens in adolescents with gingivitis should be regarded as a sign for dentists to foster more effective oral health programs. LLLT appears to be beneficial as adjuvant to basic therapy.",
publisher = "Springer, New York",
journal = "European Journal of Clinical Microbiology & Infectious Diseases",
title = "Chronic gingivitis: the prevalence of periodontopathogens and therapy efficiency",
volume = "31",
number = "8",
pages = "1911-1915",
doi = "10.1007/s10096-011-1520-7"
}

Igić, M., Kesić, L., Leković, V., Apostolović, M., Mihailović, D., Kostadinović, L.,& Milašin, J.. (2012). Chronic gingivitis: the prevalence of periodontopathogens and therapy efficiency. in European Journal of Clinical Microbiology & Infectious Diseases
Springer, New York., 31(8), 1911-1915.
https://doi.org/10.1007/s10096-011-1520-7

Igić M, Kesić L, Leković V, Apostolović M, Mihailović D, Kostadinović L, Milašin J. Chronic gingivitis: the prevalence of periodontopathogens and therapy efficiency. in European Journal of Clinical Microbiology & Infectious Diseases. 2012;31(8):1911-1915.
doi:10.1007/s10096-011-1520-7 .

Igić, M., Kesić, Ljiljana, Leković, Vojislav, Apostolović, Mirjana, Mihailović, D., Kostadinović, Ljiljana, Milašin, Jelena, "Chronic gingivitis: the prevalence of periodontopathogens and therapy efficiency" in European Journal of Clinical Microbiology & Infectious Diseases, 31, no. 8 (2012):1911-1915,
https://doi.org/10.1007/s10096-011-1520-7 . .

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Dimitrijević, B.
AU  - Leković, Vojislav
AU  - Milinković, Iva
AU  - Kenney, Barrie
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1615
AB  - Background: The purpose of this study was to estimate the prevalence of different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites, and to evaluate the correlation between herpesvirus presence and clinical parameters. Methods: A total of 80 dental implants ( mean time of loading, 4.16 +/- 1.8 years) were evaluated during the course of the study (30 peri-implantitis, 25 mucositis and 25 healthy peri-implant sites). The following clinical parameters were assessed: visible plaque index, bleeding on probing, suppuration and probing depth. A polymerase chain reaction (PCR) assay was used to identify the presence of different HCMV and EBV genotypes in peri-implant tissue plaque samples. Results: HCMV-2 was detected in 53.3% and EBV-1 in 46.6% of the 30 peri-implantitis sites evaluated. By contrast, HCMV-2 was not detected in healthy periodontal sites and EBV-1 was detected in one healthy site. A statistically significant correlation was found between the presence of HCMV-2 and EBV-1 genotypes and clinical parameters of peri-implantitis. Conclusions: The results from the present study confirmed the high prevalence of HCMV-2 and EBV-1 in the peri-implant tissue plaque of peri-implantitis sites and suggests a possible active pathogenic role of the viruses in peri-implantitis.
PB  - Wiley, Hoboken
T2  - Australian Dental Journal
T1  - Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status
VL  - 56
IS  - 4
SP  - 382
EP  - 388
DO  - 10.1111/j.1834-7819.2011.01360.x
ER  - 

@article{
author = "Janković, Saša and Aleksić, Zoran and Dimitrijević, B. and Leković, Vojislav and Milinković, Iva and Kenney, Barrie",
year = "2011",
abstract = "Background: The purpose of this study was to estimate the prevalence of different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites, and to evaluate the correlation between herpesvirus presence and clinical parameters. Methods: A total of 80 dental implants ( mean time of loading, 4.16 +/- 1.8 years) were evaluated during the course of the study (30 peri-implantitis, 25 mucositis and 25 healthy peri-implant sites). The following clinical parameters were assessed: visible plaque index, bleeding on probing, suppuration and probing depth. A polymerase chain reaction (PCR) assay was used to identify the presence of different HCMV and EBV genotypes in peri-implant tissue plaque samples. Results: HCMV-2 was detected in 53.3% and EBV-1 in 46.6% of the 30 peri-implantitis sites evaluated. By contrast, HCMV-2 was not detected in healthy periodontal sites and EBV-1 was detected in one healthy site. A statistically significant correlation was found between the presence of HCMV-2 and EBV-1 genotypes and clinical parameters of peri-implantitis. Conclusions: The results from the present study confirmed the high prevalence of HCMV-2 and EBV-1 in the peri-implant tissue plaque of peri-implantitis sites and suggests a possible active pathogenic role of the viruses in peri-implantitis.",
publisher = "Wiley, Hoboken",
journal = "Australian Dental Journal",
title = "Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status",
volume = "56",
number = "4",
pages = "382-388",
doi = "10.1111/j.1834-7819.2011.01360.x"
}

Janković, S., Aleksić, Z., Dimitrijević, B., Leković, V., Milinković, I.,& Kenney, B.. (2011). Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status. in Australian Dental Journal
Wiley, Hoboken., 56(4), 382-388.
https://doi.org/10.1111/j.1834-7819.2011.01360.x

Janković S, Aleksić Z, Dimitrijević B, Leković V, Milinković I, Kenney B. Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status. in Australian Dental Journal. 2011;56(4):382-388.
doi:10.1111/j.1834-7819.2011.01360.x .

Janković, Saša, Aleksić, Zoran, Dimitrijević, B., Leković, Vojislav, Milinković, Iva, Kenney, Barrie, "Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue status" in Australian Dental Journal, 56, no. 4 (2011):382-388,
https://doi.org/10.1111/j.1834-7819.2011.01360.x . .

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Dimitrijević, B.
AU  - Leković, Vojislav
AU  - Camargo, Paulo
AU  - Kenney, Barrie
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1623
AB  - This study evaluated the prevalence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites and the correlation between herpesvirus and clinical parameters. Fifty-six dental implants (mean time of loading, 4.27 +/- 1.6 years) were evaluated (20 peri-implantitis, 18 mucositis, 18 healthy pen-implant sites.) The clinical parameters assessed were: visible plaque index (PI), bleeding on probing (BOP), suppuration (SUP), probing depth (PD). A polymerase chain reaction assay identified HCMV and EBV in subgingival plaque samples. The percent of sites with plaque and BOP was significantly higher around mucositis and peri-implantitis compared with healthy implants (p  lt  0.05). The mean PD around the implants was significantly higher in peri-implantitis, followed by mucositis and healthy implants (p  lt  0.05). HCMV was detected in 13 (65%) and EBV in 9 (45%) of the 20 peri-implantitis sites. HCMV was found in 1 of the 18 (6%) healthy periodontal sites and EBV in 2 (11 %). A statistically significant correlation was found between presence of HCMV and EBV subgingivally and clinical parameters of peri-implantitis and healthy sites. These results confirm the high prevalence of HCMV and EBV in subgingival plaque of peri-implantitis sites and suggest the viruses have a possible active pathogenic role in peri-implantitis.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study
VL  - 40
IS  - 3
SP  - 271
EP  - 276
DO  - 10.1016/j.ijom.2010.11.004
ER  - 

@article{
author = "Janković, Saša and Aleksić, Zoran and Dimitrijević, B. and Leković, Vojislav and Camargo, Paulo and Kenney, Barrie",
year = "2011",
abstract = "This study evaluated the prevalence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites and the correlation between herpesvirus and clinical parameters. Fifty-six dental implants (mean time of loading, 4.27 +/- 1.6 years) were evaluated (20 peri-implantitis, 18 mucositis, 18 healthy pen-implant sites.) The clinical parameters assessed were: visible plaque index (PI), bleeding on probing (BOP), suppuration (SUP), probing depth (PD). A polymerase chain reaction assay identified HCMV and EBV in subgingival plaque samples. The percent of sites with plaque and BOP was significantly higher around mucositis and peri-implantitis compared with healthy implants (p  lt  0.05). The mean PD around the implants was significantly higher in peri-implantitis, followed by mucositis and healthy implants (p  lt  0.05). HCMV was detected in 13 (65%) and EBV in 9 (45%) of the 20 peri-implantitis sites. HCMV was found in 1 of the 18 (6%) healthy periodontal sites and EBV in 2 (11 %). A statistically significant correlation was found between presence of HCMV and EBV subgingivally and clinical parameters of peri-implantitis and healthy sites. These results confirm the high prevalence of HCMV and EBV in subgingival plaque of peri-implantitis sites and suggest the viruses have a possible active pathogenic role in peri-implantitis.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study",
volume = "40",
number = "3",
pages = "271-276",
doi = "10.1016/j.ijom.2010.11.004"
}

Janković, S., Aleksić, Z., Dimitrijević, B., Leković, V., Camargo, P.,& Kenney, B.. (2011). Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 40(3), 271-276.
https://doi.org/10.1016/j.ijom.2010.11.004

Janković S, Aleksić Z, Dimitrijević B, Leković V, Camargo P, Kenney B. Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study. in International Journal of Oral & Maxillofacial Surgery. 2011;40(3):271-276.
doi:10.1016/j.ijom.2010.11.004 .

Janković, Saša, Aleksić, Zoran, Dimitrijević, B., Leković, Vojislav, Camargo, Paulo, Kenney, Barrie, "Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study" in International Journal of Oral & Maxillofacial Surgery, 40, no. 3 (2011):271-276,
https://doi.org/10.1016/j.ijom.2010.11.004 . .

TY  - JOUR
AU  - Weinlaender, Michael
AU  - Leković, Vojislav
AU  - Špadijer-Gostović, Aleksandra
AU  - Miličić, Biljana
AU  - Wegscheider, Walther A.
AU  - Piehslinger, Eva
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1619
AB  - Objectives: The aim of this study was to evaluate soft tissue development at concave circular macro-grooved titanium abutments in healed sites. Material and methods: In a split-mouth pilot study 10 patients received two implants each at healed posterior sites in contralateral maxillary or mandibular jaw quadrants. Either circular macro-grooved concave study abutments or conventional convex control abutments were immediately provisionalized and received permanent crowns 3 months postimplantation. Marginal bone level, papilla index, modified plaque and bleeding index were recorded. The esthetic outcome was evaluated with standardized perpendicular pictures according to the Pink Esthetic Score (PES). Statistical analysis included the description of all variables by mean value, standard deviation and range. PES values were compared using the Wilcoxon signed rank test for paired data. Results: Cumulative survival rate for all 20 implants was 100%. At the 1-year follow up, there was no statistical significant difference of marginal bone levels between sites restored with the study (-0.11 +/- 0.77 mm) vs. the control (-0.34 +/- 0.53 mm) abutments (P>0.05). Esthetic evaluation (PES) revealed statistically significant differences in scores between the study group [study abutment group] (7.2 +/- 2.82, 8 +/- 1.89) and the control group [control abutment group] (9.5 +/- 1.58, 10.5 +/- 1.72) at the time of prosthetic delivery and the 1-year follow-up. Whereas PES scores for mesial papilla at control sites at the 1-year follow-up demonstrated statistically significant higher values, both soft tissue level and soft tissue contour at control sites revealed statistically significantly higher PES values (P lt 0.05) at time of prosthetic delivery and at 1-year follow-up when compared with study sites. Conclusions: Concave macro-grooved abutments in healed posterior maxillary and mandibular sites did not exhibit a superior soft tissue development compared with standard convex abutments.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Soft tissue development around abutments with a circular macro-groove in healed sites of partially edentulous posterior maxillae and mandibles: a clinical pilot study
VL  - 22
IS  - 7
SP  - 743
EP  - 752
DO  - 10.1111/j.1600-0501.2010.02054.x
ER  - 

@article{
author = "Weinlaender, Michael and Leković, Vojislav and Špadijer-Gostović, Aleksandra and Miličić, Biljana and Wegscheider, Walther A. and Piehslinger, Eva",
year = "2011",
abstract = "Objectives: The aim of this study was to evaluate soft tissue development at concave circular macro-grooved titanium abutments in healed sites. Material and methods: In a split-mouth pilot study 10 patients received two implants each at healed posterior sites in contralateral maxillary or mandibular jaw quadrants. Either circular macro-grooved concave study abutments or conventional convex control abutments were immediately provisionalized and received permanent crowns 3 months postimplantation. Marginal bone level, papilla index, modified plaque and bleeding index were recorded. The esthetic outcome was evaluated with standardized perpendicular pictures according to the Pink Esthetic Score (PES). Statistical analysis included the description of all variables by mean value, standard deviation and range. PES values were compared using the Wilcoxon signed rank test for paired data. Results: Cumulative survival rate for all 20 implants was 100%. At the 1-year follow up, there was no statistical significant difference of marginal bone levels between sites restored with the study (-0.11 +/- 0.77 mm) vs. the control (-0.34 +/- 0.53 mm) abutments (P>0.05). Esthetic evaluation (PES) revealed statistically significant differences in scores between the study group [study abutment group] (7.2 +/- 2.82, 8 +/- 1.89) and the control group [control abutment group] (9.5 +/- 1.58, 10.5 +/- 1.72) at the time of prosthetic delivery and the 1-year follow-up. Whereas PES scores for mesial papilla at control sites at the 1-year follow-up demonstrated statistically significant higher values, both soft tissue level and soft tissue contour at control sites revealed statistically significantly higher PES values (P lt 0.05) at time of prosthetic delivery and at 1-year follow-up when compared with study sites. Conclusions: Concave macro-grooved abutments in healed posterior maxillary and mandibular sites did not exhibit a superior soft tissue development compared with standard convex abutments.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Soft tissue development around abutments with a circular macro-groove in healed sites of partially edentulous posterior maxillae and mandibles: a clinical pilot study",
volume = "22",
number = "7",
pages = "743-752",
doi = "10.1111/j.1600-0501.2010.02054.x"
}

Weinlaender, M., Leković, V., Špadijer-Gostović, A., Miličić, B., Wegscheider, W. A.,& Piehslinger, E.. (2011). Soft tissue development around abutments with a circular macro-groove in healed sites of partially edentulous posterior maxillae and mandibles: a clinical pilot study. in Clinical Oral Implants Research
Wiley, Hoboken., 22(7), 743-752.
https://doi.org/10.1111/j.1600-0501.2010.02054.x

Weinlaender M, Leković V, Špadijer-Gostović A, Miličić B, Wegscheider WA, Piehslinger E. Soft tissue development around abutments with a circular macro-groove in healed sites of partially edentulous posterior maxillae and mandibles: a clinical pilot study. in Clinical Oral Implants Research. 2011;22(7):743-752.
doi:10.1111/j.1600-0501.2010.02054.x .

Weinlaender, Michael, Leković, Vojislav, Špadijer-Gostović, Aleksandra, Miličić, Biljana, Wegscheider, Walther A., Piehslinger, Eva, "Soft tissue development around abutments with a circular macro-groove in healed sites of partially edentulous posterior maxillae and mandibles: a clinical pilot study" in Clinical Oral Implants Research, 22, no. 7 (2011):743-752,
https://doi.org/10.1111/j.1600-0501.2010.02054.x . .

TY  - JOUR
AU  - Aleksić, Zoran
AU  - Janković, Saša
AU  - Dimitrijević, Božidar
AU  - Divnić-Resnik, Tihana
AU  - Milinković, Iva
AU  - Leković, Vojislav
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1558
AB  - Introduction. Fibrin, fibronectin, platelet derived growth factor, and transforming growth factors from platelet concetrate are crucial for tissue reparation and regeneration. Objective. This study was designed to evaluate clinical effectiveness of activated platelet-rich fibrin (PRF) membrane in treatment of gingival recession. Methods. 19 gingival recessions Miller class I or II were treated with a coronally advanced flap and the PRF membrane (PRF group). Following the elevation of the flap, bone and root surfaces were covered with the PRF membrane. After suturing, the PRF membrane was covered with a coronally advanced flap. In the same patients, 19 other gingival recessions were treated with CTG in combination with the coronally advanced flap (the CTG group). Clinical recordings were made of vertical recession depth (VRD), probing depth (PD), clinical attachment level (CAL) and keratinized tissue width (KTW) before and 12 months after mucogingival surgical treatment. Clinical evaluation of healing events was estimated with recordings of the healing index (HI). Recordings of HI were performed in the 1st, 2nd and 3rd week post-surgically. Results. Mean root coverage was significant in both groups (the PRF group 79.94% and the CTG group 88.56% %; p lt 0.01). The difference between the two tested groups was not statistically significant. Results of the keratinized tissue width showed significant increase (p lt 0.05) 12 months after the surgery in both, the PRF and CTG groups. Results of KTW showed statistical significance of recorded differences obtained in the two evaluated groups (p lt 0.05). There was no statistical significance in reduction of PD and CAL recorded in the PRF and CTG groups. The values of HI recorded in the 1st and 2nd week postoperatively were significantly enhanced in the PRF group (p lt 0.05). Conclusion. Results of this study confirm both procedures as effective with equivalence of clinical results in solving gingival recession problems. The utilization of the PRF resulted in a decreased postoperative discomfort and advanced tissue healing.
AB  - Uvod. Fibrin, fibronektin, faktor rasta poreklom iz trombocita i transformišući faktor rasta imaju presudnu ulogu u regeneraciji i reparaciji tkiva. Cilj rada. Ispitati i utvrditi značaj primene membrane od fibrina bogatog trombocitima (engl. plateletrich fibrin - PRF) u lečenju recesija gingive. Metode rada. Devetnaest obostranih gingivalnih recesija klase I ili II po Mileru lečeno je sa dva različita terapijska modaliteta. U eksperimentalnoj grupi recesija je, nakon odizanja mukoperiostnog režnja, preko izložene alveolarne kosti i korena zuba postavljena PRF membrana kao augmentacioni materijal, koja je zatim pokrivena koronarno pomerenim režnjem. U kontrolnoj grupi su izložena alveolarna kost i koren zuba prekriveni transplantatom vezivnog tkiva (TVT) uz koronarno pomereni režanj. Kod obe grupe recesija posmatrani su sledeći parametri: veličina recesije gingive, širina keratinizovane gingive, nivo pripojnog epitela i dubina sondiranja. Parametri su mereni neposredno pre hirurškog zahvata i 12 meseci kasnije. Zabeležen je i indeks zarastanja rane tokom prve tri nedelje posle operacije. Rezultati. Kod obe grupe recesija postignuto je značajno prekrivanje ogoljenog korena zuba (PRF membrana 79,94% i TVT 88,56%; p lt 0,01), dok između dve ispitivane grupe nije uočena statistički značajna razlika. Rezultati ispitivanja širine keratinizovane gingive su pokazali značajno povećanje u obe ispitivane grupe dvanaest meseci nakon hirurškog lečenja (p lt 0,05). Takođe je uočena statistički značajna razlika između posmatranih grupa (p lt 0,05) kod parametra širina keratinizovane gingive. Statističke značajnosti kada je reč o smanjenju nivoa pripojnog epitela i dubine sondiranja, kako u okviru grupa, tako i između obe ispitivane grupe (p>0,05), nije bilo. Merenjem indeksa zarastanja rane uočeni su značajno bolji rezultati u eksperimentalnoj grupi nakon prve i druge nedelje nego u kontrolnoj (p lt 0,05). Zaključak. Oba postupka pokazala su se adekvatnim u lečenju gingivalnih recesija. U kontrolnoj grupi bili su bolji rezultati u dobitku keratinizovanog tkiva, dok se eksperimentalna procedura pokazala jednostavnijom i komfornijom za samog bolesnika, uz značajno bolji postoperacioni tok.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The use of platelet-rich fibrin membrane in gingival recession treatment
T1  - Klinička primena fibrinske membrane u lečenju recesija gingive
VL  - 138
IS  - 1-2
SP  - 11
EP  - 18
DO  - 10.2298/SARH1002011A
ER  - 

@article{
author = "Aleksić, Zoran and Janković, Saša and Dimitrijević, Božidar and Divnić-Resnik, Tihana and Milinković, Iva and Leković, Vojislav",
year = "2010",
abstract = "Introduction. Fibrin, fibronectin, platelet derived growth factor, and transforming growth factors from platelet concetrate are crucial for tissue reparation and regeneration. Objective. This study was designed to evaluate clinical effectiveness of activated platelet-rich fibrin (PRF) membrane in treatment of gingival recession. Methods. 19 gingival recessions Miller class I or II were treated with a coronally advanced flap and the PRF membrane (PRF group). Following the elevation of the flap, bone and root surfaces were covered with the PRF membrane. After suturing, the PRF membrane was covered with a coronally advanced flap. In the same patients, 19 other gingival recessions were treated with CTG in combination with the coronally advanced flap (the CTG group). Clinical recordings were made of vertical recession depth (VRD), probing depth (PD), clinical attachment level (CAL) and keratinized tissue width (KTW) before and 12 months after mucogingival surgical treatment. Clinical evaluation of healing events was estimated with recordings of the healing index (HI). Recordings of HI were performed in the 1st, 2nd and 3rd week post-surgically. Results. Mean root coverage was significant in both groups (the PRF group 79.94% and the CTG group 88.56% %; p lt 0.01). The difference between the two tested groups was not statistically significant. Results of the keratinized tissue width showed significant increase (p lt 0.05) 12 months after the surgery in both, the PRF and CTG groups. Results of KTW showed statistical significance of recorded differences obtained in the two evaluated groups (p lt 0.05). There was no statistical significance in reduction of PD and CAL recorded in the PRF and CTG groups. The values of HI recorded in the 1st and 2nd week postoperatively were significantly enhanced in the PRF group (p lt 0.05). Conclusion. Results of this study confirm both procedures as effective with equivalence of clinical results in solving gingival recession problems. The utilization of the PRF resulted in a decreased postoperative discomfort and advanced tissue healing., Uvod. Fibrin, fibronektin, faktor rasta poreklom iz trombocita i transformišući faktor rasta imaju presudnu ulogu u regeneraciji i reparaciji tkiva. Cilj rada. Ispitati i utvrditi značaj primene membrane od fibrina bogatog trombocitima (engl. plateletrich fibrin - PRF) u lečenju recesija gingive. Metode rada. Devetnaest obostranih gingivalnih recesija klase I ili II po Mileru lečeno je sa dva različita terapijska modaliteta. U eksperimentalnoj grupi recesija je, nakon odizanja mukoperiostnog režnja, preko izložene alveolarne kosti i korena zuba postavljena PRF membrana kao augmentacioni materijal, koja je zatim pokrivena koronarno pomerenim režnjem. U kontrolnoj grupi su izložena alveolarna kost i koren zuba prekriveni transplantatom vezivnog tkiva (TVT) uz koronarno pomereni režanj. Kod obe grupe recesija posmatrani su sledeći parametri: veličina recesije gingive, širina keratinizovane gingive, nivo pripojnog epitela i dubina sondiranja. Parametri su mereni neposredno pre hirurškog zahvata i 12 meseci kasnije. Zabeležen je i indeks zarastanja rane tokom prve tri nedelje posle operacije. Rezultati. Kod obe grupe recesija postignuto je značajno prekrivanje ogoljenog korena zuba (PRF membrana 79,94% i TVT 88,56%; p lt 0,01), dok između dve ispitivane grupe nije uočena statistički značajna razlika. Rezultati ispitivanja širine keratinizovane gingive su pokazali značajno povećanje u obe ispitivane grupe dvanaest meseci nakon hirurškog lečenja (p lt 0,05). Takođe je uočena statistički značajna razlika između posmatranih grupa (p lt 0,05) kod parametra širina keratinizovane gingive. Statističke značajnosti kada je reč o smanjenju nivoa pripojnog epitela i dubine sondiranja, kako u okviru grupa, tako i između obe ispitivane grupe (p>0,05), nije bilo. Merenjem indeksa zarastanja rane uočeni su značajno bolji rezultati u eksperimentalnoj grupi nakon prve i druge nedelje nego u kontrolnoj (p lt 0,05). Zaključak. Oba postupka pokazala su se adekvatnim u lečenju gingivalnih recesija. U kontrolnoj grupi bili su bolji rezultati u dobitku keratinizovanog tkiva, dok se eksperimentalna procedura pokazala jednostavnijom i komfornijom za samog bolesnika, uz značajno bolji postoperacioni tok.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The use of platelet-rich fibrin membrane in gingival recession treatment, Klinička primena fibrinske membrane u lečenju recesija gingive",
volume = "138",
number = "1-2",
pages = "11-18",
doi = "10.2298/SARH1002011A"
}

Aleksić, Z., Janković, S., Dimitrijević, B., Divnić-Resnik, T., Milinković, I.,& Leković, V.. (2010). The use of platelet-rich fibrin membrane in gingival recession treatment. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 138(1-2), 11-18.
https://doi.org/10.2298/SARH1002011A

Aleksić Z, Janković S, Dimitrijević B, Divnić-Resnik T, Milinković I, Leković V. The use of platelet-rich fibrin membrane in gingival recession treatment. in Srpski arhiv za celokupno lekarstvo. 2010;138(1-2):11-18.
doi:10.2298/SARH1002011A .

Aleksić, Zoran, Janković, Saša, Dimitrijević, Božidar, Divnić-Resnik, Tihana, Milinković, Iva, Leković, Vojislav, "The use of platelet-rich fibrin membrane in gingival recession treatment" in Srpski arhiv za celokupno lekarstvo, 138, no. 1-2 (2010):11-18,
https://doi.org/10.2298/SARH1002011A . .

TY  - JOUR
AU  - Weinlaender, Michael
AU  - Leković, Vojislav
AU  - Špadijer-Gostović, Aleksandra
AU  - Miličić, Biljana
AU  - Krennmair, Gerald
AU  - Plenk, Hanns, Jr.
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1490
AB  - Objectives: A new method is introduced for the esthetic evaluation of the periimplant mucogingival complex through collection of standardized oral photographs and computer-assisted measurement of reproducible data. Using this method, different soft tissue and crown parameters in the dentogingival complex can be measured and the esthetic outcome monitored. Material and methods: A photographic device for standardized oral photography and a standard protocol for the esthetic evaluation of the crown-mucogingival complex is presented, comprising six soft tissue parameters: (1) mesial and (2) distal papilla areas, (3) mesial and (4) distal papilla heights, (5) soft tissue-crown perimeter, and (6) gingival recession. In order to demonstrate the reproducibility of standardized oral photographs and the accuracy of the measurement of the six parameters, the data obtained in each of two such standardized clinical photographs, taken at 10-14 days intervals, of the anterior maxillary region from 10 patients with no apparent dental disease were compared. For the statistical analysis of the reproducibility of these dependent data the 95% confidence interval and the coefficients of variation were calculated from measurement means and ranges of each of the above parameters, pooled from all 10 patients. Results: Statistical analysis revealed high reproducibility with no significant differences between the range of mean values of all six parameter measurements on the first and second standardized oral photograph of the same patient, respectively. Conclusion: Gingivomorphometry on standardized oral photographs can be considered to be an accurate and reproducible method for the evaluation and measurement of different dentogingival and periimplant parameters.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Gingivomorphometry - esthetic evaluation of the crown-mucogingival complex: a new method for collection and measurement of standardized and reproducible data in oral photography
VL  - 20
IS  - 5
SP  - 526
EP  - 530
DO  - 10.1111/j.1600-0501.2008.01685.x
ER  - 

@article{
author = "Weinlaender, Michael and Leković, Vojislav and Špadijer-Gostović, Aleksandra and Miličić, Biljana and Krennmair, Gerald and Plenk, Hanns, Jr.",
year = "2009",
abstract = "Objectives: A new method is introduced for the esthetic evaluation of the periimplant mucogingival complex through collection of standardized oral photographs and computer-assisted measurement of reproducible data. Using this method, different soft tissue and crown parameters in the dentogingival complex can be measured and the esthetic outcome monitored. Material and methods: A photographic device for standardized oral photography and a standard protocol for the esthetic evaluation of the crown-mucogingival complex is presented, comprising six soft tissue parameters: (1) mesial and (2) distal papilla areas, (3) mesial and (4) distal papilla heights, (5) soft tissue-crown perimeter, and (6) gingival recession. In order to demonstrate the reproducibility of standardized oral photographs and the accuracy of the measurement of the six parameters, the data obtained in each of two such standardized clinical photographs, taken at 10-14 days intervals, of the anterior maxillary region from 10 patients with no apparent dental disease were compared. For the statistical analysis of the reproducibility of these dependent data the 95% confidence interval and the coefficients of variation were calculated from measurement means and ranges of each of the above parameters, pooled from all 10 patients. Results: Statistical analysis revealed high reproducibility with no significant differences between the range of mean values of all six parameter measurements on the first and second standardized oral photograph of the same patient, respectively. Conclusion: Gingivomorphometry on standardized oral photographs can be considered to be an accurate and reproducible method for the evaluation and measurement of different dentogingival and periimplant parameters.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Gingivomorphometry - esthetic evaluation of the crown-mucogingival complex: a new method for collection and measurement of standardized and reproducible data in oral photography",
volume = "20",
number = "5",
pages = "526-530",
doi = "10.1111/j.1600-0501.2008.01685.x"
}

Weinlaender, M., Leković, V., Špadijer-Gostović, A., Miličić, B., Krennmair, G.,& Plenk, H. Jr.. (2009). Gingivomorphometry - esthetic evaluation of the crown-mucogingival complex: a new method for collection and measurement of standardized and reproducible data in oral photography. in Clinical Oral Implants Research
Wiley, Hoboken., 20(5), 526-530.
https://doi.org/10.1111/j.1600-0501.2008.01685.x

Weinlaender M, Leković V, Špadijer-Gostović A, Miličić B, Krennmair G, Plenk HJ. Gingivomorphometry - esthetic evaluation of the crown-mucogingival complex: a new method for collection and measurement of standardized and reproducible data in oral photography. in Clinical Oral Implants Research. 2009;20(5):526-530.
doi:10.1111/j.1600-0501.2008.01685.x .

Weinlaender, Michael, Leković, Vojislav, Špadijer-Gostović, Aleksandra, Miličić, Biljana, Krennmair, Gerald, Plenk, Hanns, Jr., "Gingivomorphometry - esthetic evaluation of the crown-mucogingival complex: a new method for collection and measurement of standardized and reproducible data in oral photography" in Clinical Oral Implants Research, 20, no. 5 (2009):526-530,
https://doi.org/10.1111/j.1600-0501.2008.01685.x . .

TY  - JOUR
AU  - Milićević, Radovan
AU  - Brajović, Gavrilo
AU  - Nikolić-Jakoba, Nataša
AU  - Popović, Branka
AU  - Pavlica, Dušan
AU  - Leković, Vojislav
AU  - Milašin, Jelena
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1385
AB  - INTRODUCTION Periodontitis is an inflammatory disease of the supporting tissues of teeth and is a major cause of tooth loss in adults. The onset and progression of periodontal disease is attributed to the presence of elevated levels of a consortium of pathogenic bacteria. Gram negative bacteria, mainly strict anaerobes, play the major role. OBJECTIVE The present study aimed to assess the presence of the main types of microorganisms involved in the aetiopathogenesis of periodontal disease: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Treponema denticola, Tanerella forsythia and Prevotella intermedia in different samples collected from the oral cavity of 90 patients diagnosed with periodontitis. METHOD Bacterial DNA detection was performed in diverse biological materials, namely in dental plaque, gingival tissue and saliva, by means of multiplex PCR, a technique that allows simultaneous identification of two different bacterial genomes. RESULTS In the dental plaque of the periodontitis patients, Treponema denticola dominated. In the gingival tissue, Tannerella forsythia and Treponema denticola were the microbiota most frequently detected, whilst in saliva Treponema denticola and Eikenella corrodens were found with the highest percentage. CONCLUSION The identification of microorganisms by multiplex PCR is specific and sensitive. Rapid and precise assessment of different types of periodontopathogens is extremely important for early detection of the infection and consequently for the prevention and treatment of periodontal disease. In everyday clinical practice, for routine bacterial evaluation in patients with periodontal disease, the dental plaque is the most suitable biological material, because it is the richest in periodontal bacteria.
AB  - Uvod Epidemiološki podaci iz čitavog sveta ukazuju na veliku rasprostranjenost gingivitisa i parodontopatije, oboljenja potpornog aparata zuba. U etiopatogenezi oboljenja parodoncijuma ključnu ulogu igraju različiti rodovi Gram-negativnih bakterija, ponajviše striktnih anaeroba. Cilj rada Cilj rada je bio da se ispita postojanje genoma glavnih parodontopatogenih mikroorganizama Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Treponema denticola, Tanerella forsythia i Prevotella intermedia u različitim uzorcima poreklom iz usne duplje pacijenata s klinički dijagnostikovanom parodontopatijom. Metod rada Kao biološki materijal u kojem je dokazivano postojanje DNK mikroorganizama korišćeni su zubni plak, tkivo zapaljene gingive i pljuvačka. Za otkrivanje bakterijskog genoma primenjena je multipleks tehnika reakcije lančanog umnožavanja (engl. polymerase chain reaction PCR), odnosno simultana amplifikacija gena dve različite bakterije. Rezultati S manjom ili većom učestalošću, u svim ispitanim uzorcima utvrđeno je postojanje parodontopatogenih mikroorganizama. U zubnom plaku osoba obolelih od parodontopatije najčešći je bio genom vrste Treponema denticola. U tkivu parodoncijuma otkriveno je u najvećem procentu postojanje genoma vrsta Tannerella forsythia i Treponema denticola, što je odlika hroničnog oblika parodontopatije, a u pljuvački ispitanika dominirale su Treponema denticola i Eikinella corrodens. Najmanje ukupno postojanje bakterija je zapaženo u pljuvački. Zaključak Primenjeni metod PCR ima veliku osetljivost i specifičnost. Brzo i precizno otkrivanje mikroorganizama je veoma važno za pravovremeno dijagnostikovanje infekcije, a samim tim i za prevenciju i lečenje parodontopatija. U svakodnevnoj kliničkoj praksi optimalan biološki materijal za dokazivanje parodontopatogena kod osoba obolelih od parodontopatije je zubni plak, koji se smatra pouzdanim pokazateljem zastupljenosti pojedinih bakterija u obolelom parodoncijumu.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Identification of periodontopathogen microorganisms by PCR technique
T1  - Identifikacija parodontopatogenih mikroorganizama PCR tehnikom
VL  - 136
IS  - 9-10
SP  - 476
EP  - 480
DO  - 10.2298/SARH0810476M
ER  - 

@article{
author = "Milićević, Radovan and Brajović, Gavrilo and Nikolić-Jakoba, Nataša and Popović, Branka and Pavlica, Dušan and Leković, Vojislav and Milašin, Jelena",
year = "2008",
abstract = "INTRODUCTION Periodontitis is an inflammatory disease of the supporting tissues of teeth and is a major cause of tooth loss in adults. The onset and progression of periodontal disease is attributed to the presence of elevated levels of a consortium of pathogenic bacteria. Gram negative bacteria, mainly strict anaerobes, play the major role. OBJECTIVE The present study aimed to assess the presence of the main types of microorganisms involved in the aetiopathogenesis of periodontal disease: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Treponema denticola, Tanerella forsythia and Prevotella intermedia in different samples collected from the oral cavity of 90 patients diagnosed with periodontitis. METHOD Bacterial DNA detection was performed in diverse biological materials, namely in dental plaque, gingival tissue and saliva, by means of multiplex PCR, a technique that allows simultaneous identification of two different bacterial genomes. RESULTS In the dental plaque of the periodontitis patients, Treponema denticola dominated. In the gingival tissue, Tannerella forsythia and Treponema denticola were the microbiota most frequently detected, whilst in saliva Treponema denticola and Eikenella corrodens were found with the highest percentage. CONCLUSION The identification of microorganisms by multiplex PCR is specific and sensitive. Rapid and precise assessment of different types of periodontopathogens is extremely important for early detection of the infection and consequently for the prevention and treatment of periodontal disease. In everyday clinical practice, for routine bacterial evaluation in patients with periodontal disease, the dental plaque is the most suitable biological material, because it is the richest in periodontal bacteria., Uvod Epidemiološki podaci iz čitavog sveta ukazuju na veliku rasprostranjenost gingivitisa i parodontopatije, oboljenja potpornog aparata zuba. U etiopatogenezi oboljenja parodoncijuma ključnu ulogu igraju različiti rodovi Gram-negativnih bakterija, ponajviše striktnih anaeroba. Cilj rada Cilj rada je bio da se ispita postojanje genoma glavnih parodontopatogenih mikroorganizama Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Treponema denticola, Tanerella forsythia i Prevotella intermedia u različitim uzorcima poreklom iz usne duplje pacijenata s klinički dijagnostikovanom parodontopatijom. Metod rada Kao biološki materijal u kojem je dokazivano postojanje DNK mikroorganizama korišćeni su zubni plak, tkivo zapaljene gingive i pljuvačka. Za otkrivanje bakterijskog genoma primenjena je multipleks tehnika reakcije lančanog umnožavanja (engl. polymerase chain reaction PCR), odnosno simultana amplifikacija gena dve različite bakterije. Rezultati S manjom ili većom učestalošću, u svim ispitanim uzorcima utvrđeno je postojanje parodontopatogenih mikroorganizama. U zubnom plaku osoba obolelih od parodontopatije najčešći je bio genom vrste Treponema denticola. U tkivu parodoncijuma otkriveno je u najvećem procentu postojanje genoma vrsta Tannerella forsythia i Treponema denticola, što je odlika hroničnog oblika parodontopatije, a u pljuvački ispitanika dominirale su Treponema denticola i Eikinella corrodens. Najmanje ukupno postojanje bakterija je zapaženo u pljuvački. Zaključak Primenjeni metod PCR ima veliku osetljivost i specifičnost. Brzo i precizno otkrivanje mikroorganizama je veoma važno za pravovremeno dijagnostikovanje infekcije, a samim tim i za prevenciju i lečenje parodontopatija. U svakodnevnoj kliničkoj praksi optimalan biološki materijal za dokazivanje parodontopatogena kod osoba obolelih od parodontopatije je zubni plak, koji se smatra pouzdanim pokazateljem zastupljenosti pojedinih bakterija u obolelom parodoncijumu.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Identification of periodontopathogen microorganisms by PCR technique, Identifikacija parodontopatogenih mikroorganizama PCR tehnikom",
volume = "136",
number = "9-10",
pages = "476-480",
doi = "10.2298/SARH0810476M"
}

Milićević, R., Brajović, G., Nikolić-Jakoba, N., Popović, B., Pavlica, D., Leković, V.,& Milašin, J.. (2008). Identification of periodontopathogen microorganisms by PCR technique. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 136(9-10), 476-480.
https://doi.org/10.2298/SARH0810476M

Milićević R, Brajović G, Nikolić-Jakoba N, Popović B, Pavlica D, Leković V, Milašin J. Identification of periodontopathogen microorganisms by PCR technique. in Srpski arhiv za celokupno lekarstvo. 2008;136(9-10):476-480.
doi:10.2298/SARH0810476M .

Milićević, Radovan, Brajović, Gavrilo, Nikolić-Jakoba, Nataša, Popović, Branka, Pavlica, Dušan, Leković, Vojislav, Milašin, Jelena, "Identification of periodontopathogen microorganisms by PCR technique" in Srpski arhiv za celokupno lekarstvo, 136, no. 9-10 (2008):476-480,
https://doi.org/10.2298/SARH0810476M . .

TY  - JOUR
AU  - Aleksić, Zoran
AU  - Janković, Saša
AU  - Dimitrijević, Božidar
AU  - Pucar, Ana
AU  - Lazić, Vojkan
AU  - Leković, Vojislav
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1437
AB  - Introduction Root coverage supported with complete regeneration of lost periodontal tissues represents the ultimate goal of gingival recession treatment. Objective This study was designed to evaluate clinical effectiveness of platelet rich plasma gel (PRP) with connective tissue graft (CTG) in the treatment of gingival recession. METHOD 15 gingival recessions Miller class I or II were treated with CTG and PRP (group PRP). Connective tissue graft was harvested from the premolar region using trap door technique. After elevation of the flap, the regional bone and root surface were smeared with activated PRP gel. CTG was also irrigated with PRP gel before placement over the exposed root surface and local bone. Fixed CTG was covered with a coronally advanced flap. The same number of gingival recessions were treated with CTG in combination with the coronally advanced flap with no PRP gel (group TVT). Clinical recordings included recession depth (RD), probing depth (PD), clinical attachment level (CAL) and keratinized tissue width (KT) before and 1 year after mucogingival surgical treatment. Results Mean value of RD was significantly decreased from 4.93±0.86 mm to 0.60±0.37 (p lt 0.01) with CTG and PRP and from 4.76±0.74 mm to 0.63±0.29 mm (p lt 0.01) in CTG group. This difference was not statistically significant. Results of the keratinized tissue width showed significant increase from 0.88± 0.30 mm presurgery to 3.78±0.49 mm (p lt 0.01) six months after treatment in PRP group and from 0.90±0.34 mm to 3.15±0.41 in TVT group (p lt 0.01). This difference was statistically significant (p>0.05). No statistically significant differences were observed between treatment groups in CAL and PD. Conclusion Clinical results validate both procedures as effective and highly predictable surgical techniques in solving gingival recession problem. Histological evaluation may confirm advantage of PRP use related to regeneration of periodontal tissues.
AB  - Uvod. Recesija gingive je jedan od najsloženijih problema savremene stomatologije. Iznalaženje novih terapijskih metoda za rešavanje ovog problema je značajan segment istraživanja u parodontologiji. Cilj rada. Cilj rada je bio da se procene klinički efekti primene plazme bogate trombocitima (PBT) u kombinaciji sa transplantatom vezivnog tkiva (TVT) u lečenju recesije gingive. Metod rada. Istraživanje je obuhvatilo 15 bolesnika s obostranim recesijama gingive klase II i III po Mileru (Miller). Metodološki koncept se zasnivao na metodu podeljenih usta. U lečenju 15 recesija primenjen je TVT u kombinaciji sa koronarno pozicioniranim režnjem uz primenu aktiviranog koncentrata trombocita (PBT grupa). Isti broj recesija na suprotnoj strani vilice zbrinjavan je autotransplantatom vezivnog tkiva i periosta u kombinaciji sa koronarno pozicioniranim režnjem (TVT grupa). Za procenu stanja parodoncijuma i efikasnosti primenjenih hirurških postupaka korišćeni su sledeći klinički parametri: vertikalna dubina recesije (VDR), nivo pripojnog epitela i širina keratinizovane gingive. Nivo oralne higijene je utvrđivan plak-indeksom po Silnes- Lou (Silness-Löu), a stanje gingive gingivnim indeksom po Lou-Silnesu (Löu-Silness). Rezultati. Na osnovu analize srednje vrednost za dubinu recesije (VDR), ustanovljeno je statistički značajno smanjenje vrednosti ovog parametra šest meseci posle tretmana u PBT grupi (sa 4,93±0,86 mm na 0,60±0,37 mm; p lt 0,01). U TVT grupi, u kojoj je vrednost VDR pre lečenja bila 4,76±0,74 mm, posle šest meseci dobijena je vrednost od 0,63±0,29 mm (p lt 0,01). U PBT grupi je posle opservacionog perioda zabeleženo proširenje zone keratinizovanog tkiva za 2,90 mm, dok je u istom periodu vrednost ovog parametra u TVT grupi bila 2,25 mm. Poređenjem prosečne promene vrednosti kliničkih parametara u okviru obe eksperimentalne grupe, samo je kod promene širine keratinizovanog tkiva zabeležena statistička značajnost (p lt 0,05). Zaključak. Rezultati ove kliničke studije ukazuju na izuzetnu efikasnost oba primenjena postupka u lečenju recesije gingive.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Clinical impact of platelet rich plasma in treatment of gingival recessions
T1  - Primena plazme bogate trombocitima u rekonstruktivnoj mukogingivnoj hirurgiji
VL  - 136
IS  - 3-4
SP  - 95
EP  - 103
DO  - 10.2298/SARH0804095A
ER  - 

@article{
author = "Aleksić, Zoran and Janković, Saša and Dimitrijević, Božidar and Pucar, Ana and Lazić, Vojkan and Leković, Vojislav",
year = "2008",
abstract = "Introduction Root coverage supported with complete regeneration of lost periodontal tissues represents the ultimate goal of gingival recession treatment. Objective This study was designed to evaluate clinical effectiveness of platelet rich plasma gel (PRP) with connective tissue graft (CTG) in the treatment of gingival recession. METHOD 15 gingival recessions Miller class I or II were treated with CTG and PRP (group PRP). Connective tissue graft was harvested from the premolar region using trap door technique. After elevation of the flap, the regional bone and root surface were smeared with activated PRP gel. CTG was also irrigated with PRP gel before placement over the exposed root surface and local bone. Fixed CTG was covered with a coronally advanced flap. The same number of gingival recessions were treated with CTG in combination with the coronally advanced flap with no PRP gel (group TVT). Clinical recordings included recession depth (RD), probing depth (PD), clinical attachment level (CAL) and keratinized tissue width (KT) before and 1 year after mucogingival surgical treatment. Results Mean value of RD was significantly decreased from 4.93±0.86 mm to 0.60±0.37 (p lt 0.01) with CTG and PRP and from 4.76±0.74 mm to 0.63±0.29 mm (p lt 0.01) in CTG group. This difference was not statistically significant. Results of the keratinized tissue width showed significant increase from 0.88± 0.30 mm presurgery to 3.78±0.49 mm (p lt 0.01) six months after treatment in PRP group and from 0.90±0.34 mm to 3.15±0.41 in TVT group (p lt 0.01). This difference was statistically significant (p>0.05). No statistically significant differences were observed between treatment groups in CAL and PD. Conclusion Clinical results validate both procedures as effective and highly predictable surgical techniques in solving gingival recession problem. Histological evaluation may confirm advantage of PRP use related to regeneration of periodontal tissues., Uvod. Recesija gingive je jedan od najsloženijih problema savremene stomatologije. Iznalaženje novih terapijskih metoda za rešavanje ovog problema je značajan segment istraživanja u parodontologiji. Cilj rada. Cilj rada je bio da se procene klinički efekti primene plazme bogate trombocitima (PBT) u kombinaciji sa transplantatom vezivnog tkiva (TVT) u lečenju recesije gingive. Metod rada. Istraživanje je obuhvatilo 15 bolesnika s obostranim recesijama gingive klase II i III po Mileru (Miller). Metodološki koncept se zasnivao na metodu podeljenih usta. U lečenju 15 recesija primenjen je TVT u kombinaciji sa koronarno pozicioniranim režnjem uz primenu aktiviranog koncentrata trombocita (PBT grupa). Isti broj recesija na suprotnoj strani vilice zbrinjavan je autotransplantatom vezivnog tkiva i periosta u kombinaciji sa koronarno pozicioniranim režnjem (TVT grupa). Za procenu stanja parodoncijuma i efikasnosti primenjenih hirurških postupaka korišćeni su sledeći klinički parametri: vertikalna dubina recesije (VDR), nivo pripojnog epitela i širina keratinizovane gingive. Nivo oralne higijene je utvrđivan plak-indeksom po Silnes- Lou (Silness-Löu), a stanje gingive gingivnim indeksom po Lou-Silnesu (Löu-Silness). Rezultati. Na osnovu analize srednje vrednost za dubinu recesije (VDR), ustanovljeno je statistički značajno smanjenje vrednosti ovog parametra šest meseci posle tretmana u PBT grupi (sa 4,93±0,86 mm na 0,60±0,37 mm; p lt 0,01). U TVT grupi, u kojoj je vrednost VDR pre lečenja bila 4,76±0,74 mm, posle šest meseci dobijena je vrednost od 0,63±0,29 mm (p lt 0,01). U PBT grupi je posle opservacionog perioda zabeleženo proširenje zone keratinizovanog tkiva za 2,90 mm, dok je u istom periodu vrednost ovog parametra u TVT grupi bila 2,25 mm. Poređenjem prosečne promene vrednosti kliničkih parametara u okviru obe eksperimentalne grupe, samo je kod promene širine keratinizovanog tkiva zabeležena statistička značajnost (p lt 0,05). Zaključak. Rezultati ove kliničke studije ukazuju na izuzetnu efikasnost oba primenjena postupka u lečenju recesije gingive.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Clinical impact of platelet rich plasma in treatment of gingival recessions, Primena plazme bogate trombocitima u rekonstruktivnoj mukogingivnoj hirurgiji",
volume = "136",
number = "3-4",
pages = "95-103",
doi = "10.2298/SARH0804095A"
}

Aleksić, Z., Janković, S., Dimitrijević, B., Pucar, A., Lazić, V.,& Leković, V.. (2008). Clinical impact of platelet rich plasma in treatment of gingival recessions. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 136(3-4), 95-103.
https://doi.org/10.2298/SARH0804095A

Aleksić Z, Janković S, Dimitrijević B, Pucar A, Lazić V, Leković V. Clinical impact of platelet rich plasma in treatment of gingival recessions. in Srpski arhiv za celokupno lekarstvo. 2008;136(3-4):95-103.
doi:10.2298/SARH0804095A .

Aleksić, Zoran, Janković, Saša, Dimitrijević, Božidar, Pucar, Ana, Lazić, Vojkan, Leković, Vojislav, "Clinical impact of platelet rich plasma in treatment of gingival recessions" in Srpski arhiv za celokupno lekarstvo, 136, no. 3-4 (2008):95-103,
https://doi.org/10.2298/SARH0804095A . .

TY  - JOUR
AU  - Pucar, Ana
AU  - Milašin, Jelena
AU  - Leković, Vojislav
AU  - Vukadinović, Miroslav
AU  - Ristić, Miljko
AU  - Putnik, Svetozar
AU  - Kenney, Barrie
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1349
AB  - Chronic infections, such as periodontitis, have been associated with an increase for atherosclerosis and coronary artery disease. The aim of this study was to investigate biopsy samples of coronary and internal mammary arteries for the presence of putative pathogenic bacteria (Porphyromanas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia, and Tannerella forsythensis), Chlamydia pneumoniae, and human cytomegalovirus (CMV). Methods: Patients with a diagnosis of coronary artery disease were included in the study. fifteen coronary arteries with atherosclerosis and 15 internal mammary arteries without clinically assessable atherosclerotic degeneration were investigated. Both groups of specimens were obtained during coronary artery bypass grafting surgery. In all cases, the coronary and mammary artery specimens were taken from the same patient. The detection of periodontal pathogens, C. pneumoniae, and CMV was done by polymerase chain reaction analysis. Results: Bacterial DNA was found in nine of 15 (60%) coronary artery biopsy samples: P. gingivalis in eight (53.33%), A. actinomycetemcomitans in four (26.67%), P. intermedia in five (33.33%), and T. forsythensis in two (13.33%) samples; CMV was detected in 10 (66.67%) samples, and c. pneumoniae was detected in five (33.33%) samples. Some of the samples contained more than one type of bacteria. Periodontal pathogens were not detected in internal mammary artery biopsies, whereas CMV was present in seven (46.67%) samples and C. pneumoniae was present in six (40%) samples. Conclusion: The absence of putative pathogenic bacteria in internal mammary arteries, which are known to be affected rarely by atherosclerotic changes, and their presence in a high percentage of atherosclerotic coronary arteries support the concept that periodontal organisms are associated with the development and progression of atherosclerosis.
PB  - Wiley, Hoboken
T2  - Journal of Periodontology
T1  - Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries
VL  - 78
IS  - 4
SP  - 677
EP  - 682
DO  - 10.1902/jop.2007.060062
ER  - 

@article{
author = "Pucar, Ana and Milašin, Jelena and Leković, Vojislav and Vukadinović, Miroslav and Ristić, Miljko and Putnik, Svetozar and Kenney, Barrie",
year = "2007",
abstract = "Chronic infections, such as periodontitis, have been associated with an increase for atherosclerosis and coronary artery disease. The aim of this study was to investigate biopsy samples of coronary and internal mammary arteries for the presence of putative pathogenic bacteria (Porphyromanas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia, and Tannerella forsythensis), Chlamydia pneumoniae, and human cytomegalovirus (CMV). Methods: Patients with a diagnosis of coronary artery disease were included in the study. fifteen coronary arteries with atherosclerosis and 15 internal mammary arteries without clinically assessable atherosclerotic degeneration were investigated. Both groups of specimens were obtained during coronary artery bypass grafting surgery. In all cases, the coronary and mammary artery specimens were taken from the same patient. The detection of periodontal pathogens, C. pneumoniae, and CMV was done by polymerase chain reaction analysis. Results: Bacterial DNA was found in nine of 15 (60%) coronary artery biopsy samples: P. gingivalis in eight (53.33%), A. actinomycetemcomitans in four (26.67%), P. intermedia in five (33.33%), and T. forsythensis in two (13.33%) samples; CMV was detected in 10 (66.67%) samples, and c. pneumoniae was detected in five (33.33%) samples. Some of the samples contained more than one type of bacteria. Periodontal pathogens were not detected in internal mammary artery biopsies, whereas CMV was present in seven (46.67%) samples and C. pneumoniae was present in six (40%) samples. Conclusion: The absence of putative pathogenic bacteria in internal mammary arteries, which are known to be affected rarely by atherosclerotic changes, and their presence in a high percentage of atherosclerotic coronary arteries support the concept that periodontal organisms are associated with the development and progression of atherosclerosis.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontology",
title = "Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries",
volume = "78",
number = "4",
pages = "677-682",
doi = "10.1902/jop.2007.060062"
}

Pucar, A., Milašin, J., Leković, V., Vukadinović, M., Ristić, M., Putnik, S.,& Kenney, B.. (2007). Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries. in Journal of Periodontology
Wiley, Hoboken., 78(4), 677-682.
https://doi.org/10.1902/jop.2007.060062

Pucar A, Milašin J, Leković V, Vukadinović M, Ristić M, Putnik S, Kenney B. Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries. in Journal of Periodontology. 2007;78(4):677-682.
doi:10.1902/jop.2007.060062 .

Pucar, Ana, Milašin, Jelena, Leković, Vojislav, Vukadinović, Miroslav, Ristić, Miljko, Putnik, Svetozar, Kenney, Barrie, "Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries" in Journal of Periodontology, 78, no. 4 (2007):677-682,
https://doi.org/10.1902/jop.2007.060062 . .

TY  - JOUR
AU  - Leković, Vojislav
AU  - Camargo, PM
AU  - Weinlaender, Michael
AU  - Vasilić, N
AU  - Aleksić, Zoran
AU  - Kenney, Barrie
PY  - 2003
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1187
AB  - Objective: A combination of platelet-rich plasma (PRP), bovine porous bone mineral (BPBM) and guided tissue regeneration (GTR) has been shown to be effective as regenerative treatment for intrabony periodontal defects. The purpose of this study was to evaluate the effectiveness of PRP, BPBM and GTR used in combination as regenerative treatment for grade II molar furcation defects in humans. Material and methods: Using a split-mouth design, a total of 52 grade II mandibular molar furcation defects were treated either with PRP/BPBM/GTR (experimental group, n =26) or with an open flap debridement (control group, n =26). The primary outcomes evaluated in this study included changes in pocket depth, attachment level and re-entry bone levels (horizontal and vertical) between baseline and 6 months postoperatively. Results: The results showed that the experimental group presented with significantly greater pocket reduction (4.07+/-0.33 mm for experimental and 2.49+/-0.38 mm for control sites), gain in clinical attachment (3.29 +/- 0.42 mm for experimental and 1.68+/-0.31 mm for control sites), vertical defect fill (2.56+/- 0.36 mm for experimental and -0.19+/-0.02 for control sites) and horizontal defect fill (2.28+/-0.33 mm for experimental and 0.08+/-0.02 mm for control sites) than the control group. Conclusions: It was concluded that the PRP/BPBM/GTR combined technique is an effective modality of regenerative treatment for mandibular grade II furcation defects. Further studies are necessary to elucidate the role played by each component of the combined therapy in achieving these results.
PB  - Wiley, Hoboken
T2  - Journal of Clinical Periodontology
T1  - Effectiveness of a combination of platelet-rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans
VL  - 30
IS  - 8
SP  - 746
EP  - 751
DO  - 10.1034/j.1600-051X.2003.00368.x
ER  - 

@article{
author = "Leković, Vojislav and Camargo, PM and Weinlaender, Michael and Vasilić, N and Aleksić, Zoran and Kenney, Barrie",
year = "2003",
abstract = "Objective: A combination of platelet-rich plasma (PRP), bovine porous bone mineral (BPBM) and guided tissue regeneration (GTR) has been shown to be effective as regenerative treatment for intrabony periodontal defects. The purpose of this study was to evaluate the effectiveness of PRP, BPBM and GTR used in combination as regenerative treatment for grade II molar furcation defects in humans. Material and methods: Using a split-mouth design, a total of 52 grade II mandibular molar furcation defects were treated either with PRP/BPBM/GTR (experimental group, n =26) or with an open flap debridement (control group, n =26). The primary outcomes evaluated in this study included changes in pocket depth, attachment level and re-entry bone levels (horizontal and vertical) between baseline and 6 months postoperatively. Results: The results showed that the experimental group presented with significantly greater pocket reduction (4.07+/-0.33 mm for experimental and 2.49+/-0.38 mm for control sites), gain in clinical attachment (3.29 +/- 0.42 mm for experimental and 1.68+/-0.31 mm for control sites), vertical defect fill (2.56+/- 0.36 mm for experimental and -0.19+/-0.02 for control sites) and horizontal defect fill (2.28+/-0.33 mm for experimental and 0.08+/-0.02 mm for control sites) than the control group. Conclusions: It was concluded that the PRP/BPBM/GTR combined technique is an effective modality of regenerative treatment for mandibular grade II furcation defects. Further studies are necessary to elucidate the role played by each component of the combined therapy in achieving these results.",
publisher = "Wiley, Hoboken",
journal = "Journal of Clinical Periodontology",
title = "Effectiveness of a combination of platelet-rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans",
volume = "30",
number = "8",
pages = "746-751",
doi = "10.1034/j.1600-051X.2003.00368.x"
}

Leković, V., Camargo, P., Weinlaender, M., Vasilić, N., Aleksić, Z.,& Kenney, B.. (2003). Effectiveness of a combination of platelet-rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans. in Journal of Clinical Periodontology
Wiley, Hoboken., 30(8), 746-751.
https://doi.org/10.1034/j.1600-051X.2003.00368.x

Leković V, Camargo P, Weinlaender M, Vasilić N, Aleksić Z, Kenney B. Effectiveness of a combination of platelet-rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans. in Journal of Clinical Periodontology. 2003;30(8):746-751.
doi:10.1034/j.1600-051X.2003.00368.x .

Leković, Vojislav, Camargo, PM, Weinlaender, Michael, Vasilić, N, Aleksić, Zoran, Kenney, Barrie, "Effectiveness of a combination of platelet-rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans" in Journal of Clinical Periodontology, 30, no. 8 (2003):746-751,
https://doi.org/10.1034/j.1600-051X.2003.00368.x . .

TY  - JOUR
AU  - Leković, Vojislav
AU  - Aleksić, Zoran
PY  - 2003
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1177
AB  - The aim of this study was to evaluate the clinical effectiveness of platelet-rich plasma in promoting periodontal regeneration. Twenty paired infrabony defects were treated and surgically re-entered six months after treatment. Experimental sites were grafted with a combination of platelet-rich plasma and bovine porous bone mineral and received a bovine derived collagen membrane.Control sites were treated with an open flap debridment. Preoperative clinical parameters were similar for the experimental and control group. Post surgical measurements taken a at six months revealed that both treatment modalities resulted in significant pocket depth reduction, clinical attachment gain and defect fill as compared to baseline values. The differences observed between the experimental and control groups were 2.37±0.22mm on buccal and 2.31±0.25mm on lingual sites for pocket depth, 3.16±0.43 on buccal and 3.04±0.38mm on lingual sites for gain in clinical attachment level, and 3.54±0.72mm on buccal and 3.51±0.81mm on lingual sites for defect fill. Based on the results of the present study,it was concluded that platelet- rich plasma in combination with bovine porous bone mineral and bovine derived collagen membrane enhance the results achieved with standard surgical procedure in promoting clinical signs of periodontal regeneration in infrabony defects present in patients with advanced periodontitis.
AB  - Regeneracija parodoncijuma podrazumeva regenerisanje izgubljenih potpornih tkiva, uključujući novi acelularan cement koji je čvrsto pripojen na površinu dentina korena zuba, nova funkcionalno orijentisana periodontalna vlakna koja su inkorporirana u novoformirani cement zuba i novu kost, za koju se takođe pripajaju nova periodontalna vlakna.Posebne terapijske procedure su uvedene u kliničku praksu da bi se postigla regeneracija potpornih tkiva zuba. Ovo podrazumeva primenu različitih tipova režanj operacija, kombinaciju režanj operacija sa homo i heterotransplantatima, kao i različite vrste sintetskih zamena za kost, u kombinaciji sa biomembranama i faktorima rasta (Emdogain®,BMP,PDGF, TGFa, TGFb). Sagledavajući sve mogućnosti cilj istraživanja je bio da uporedimo efekte primene plazme bogate trombocitima, koštanog poroznog materijala bovinog porekla i biomembrane u odnosu na režanj operaciju kao standardan hirurški zahvat. Dvadeset ijedan defekt je hirurški tretiran po metodi podeljenih usta. Kontrolna grupa infrakoštanih defekata je rekostruisana standardnom kirurškom procedurom, dok je eksperimentalna grupa defekata rekonstruisana kombinacijom PBT,KPMB-a i resorbtivne biomembrane. Na osnovu rezultata dobijenih merenjem dubine parodontalnih džepova, nivoa pripojnog epitela nivoa alveolarne kosti i nivoa koštanog defekta koji su dobijem upoređivanjem srednjih vrednosti svih merenja pre operativnog zahvata i 6 meseci postoperativno, može se zaključiti da su daleko povoljniji efekti postignuti u eksperimentalnoj grupi za sve ispitivane parametrara.. Primenom PET, KPMBP i resorptivnih biomembrana potspešuje se regeneracija parodontalnih tkiva i postižu povoljniji efekti u pogledu koronarne lokacije pripojnog epitela, kao i redukcije infrakoštanih defekata parodoncijuma što ukazuje na veliki stepen razvoja regenerativnih procesa u parodoncijumu, a posebno regenerativnog potencijala alveolarne kosti. Materijal i metodologija koja je upotrebljena u ovom istraživanju poseduju potencijal da promovišu pravu parodontalnu regeneraciju, ali njihovu predvidljivost u dobijanju rezultata od velike vrednosti tek treba utvrditi.
PB  - Univerzitet u Beogradu - Medicinski fakultet, Beograd
T2  - Medicinska istraživanja
T1  - The use of growth factors in regenerative periodontal surgery
T1  - Primena faktora rasta u regenerativnoj terapiji parodontopatija
VL  - 37
IS  - 3
SP  - 58
EP  - 65
UR  - https://hdl.handle.net/21.15107/rcub_smile_1177
ER  - 

@article{
author = "Leković, Vojislav and Aleksić, Zoran",
year = "2003",
abstract = "The aim of this study was to evaluate the clinical effectiveness of platelet-rich plasma in promoting periodontal regeneration. Twenty paired infrabony defects were treated and surgically re-entered six months after treatment. Experimental sites were grafted with a combination of platelet-rich plasma and bovine porous bone mineral and received a bovine derived collagen membrane.Control sites were treated with an open flap debridment. Preoperative clinical parameters were similar for the experimental and control group. Post surgical measurements taken a at six months revealed that both treatment modalities resulted in significant pocket depth reduction, clinical attachment gain and defect fill as compared to baseline values. The differences observed between the experimental and control groups were 2.37±0.22mm on buccal and 2.31±0.25mm on lingual sites for pocket depth, 3.16±0.43 on buccal and 3.04±0.38mm on lingual sites for gain in clinical attachment level, and 3.54±0.72mm on buccal and 3.51±0.81mm on lingual sites for defect fill. Based on the results of the present study,it was concluded that platelet- rich plasma in combination with bovine porous bone mineral and bovine derived collagen membrane enhance the results achieved with standard surgical procedure in promoting clinical signs of periodontal regeneration in infrabony defects present in patients with advanced periodontitis., Regeneracija parodoncijuma podrazumeva regenerisanje izgubljenih potpornih tkiva, uključujući novi acelularan cement koji je čvrsto pripojen na površinu dentina korena zuba, nova funkcionalno orijentisana periodontalna vlakna koja su inkorporirana u novoformirani cement zuba i novu kost, za koju se takođe pripajaju nova periodontalna vlakna.Posebne terapijske procedure su uvedene u kliničku praksu da bi se postigla regeneracija potpornih tkiva zuba. Ovo podrazumeva primenu različitih tipova režanj operacija, kombinaciju režanj operacija sa homo i heterotransplantatima, kao i različite vrste sintetskih zamena za kost, u kombinaciji sa biomembranama i faktorima rasta (Emdogain®,BMP,PDGF, TGFa, TGFb). Sagledavajući sve mogućnosti cilj istraživanja je bio da uporedimo efekte primene plazme bogate trombocitima, koštanog poroznog materijala bovinog porekla i biomembrane u odnosu na režanj operaciju kao standardan hirurški zahvat. Dvadeset ijedan defekt je hirurški tretiran po metodi podeljenih usta. Kontrolna grupa infrakoštanih defekata je rekostruisana standardnom kirurškom procedurom, dok je eksperimentalna grupa defekata rekonstruisana kombinacijom PBT,KPMB-a i resorbtivne biomembrane. Na osnovu rezultata dobijenih merenjem dubine parodontalnih džepova, nivoa pripojnog epitela nivoa alveolarne kosti i nivoa koštanog defekta koji su dobijem upoređivanjem srednjih vrednosti svih merenja pre operativnog zahvata i 6 meseci postoperativno, može se zaključiti da su daleko povoljniji efekti postignuti u eksperimentalnoj grupi za sve ispitivane parametrara.. Primenom PET, KPMBP i resorptivnih biomembrana potspešuje se regeneracija parodontalnih tkiva i postižu povoljniji efekti u pogledu koronarne lokacije pripojnog epitela, kao i redukcije infrakoštanih defekata parodoncijuma što ukazuje na veliki stepen razvoja regenerativnih procesa u parodoncijumu, a posebno regenerativnog potencijala alveolarne kosti. Materijal i metodologija koja je upotrebljena u ovom istraživanju poseduju potencijal da promovišu pravu parodontalnu regeneraciju, ali njihovu predvidljivost u dobijanju rezultata od velike vrednosti tek treba utvrditi.",
publisher = "Univerzitet u Beogradu - Medicinski fakultet, Beograd",
journal = "Medicinska istraživanja",
title = "The use of growth factors in regenerative periodontal surgery, Primena faktora rasta u regenerativnoj terapiji parodontopatija",
volume = "37",
number = "3",
pages = "58-65",
url = "https://hdl.handle.net/21.15107/rcub_smile_1177"
}

Leković, V.,& Aleksić, Z.. (2003). The use of growth factors in regenerative periodontal surgery. in Medicinska istraživanja
Univerzitet u Beogradu - Medicinski fakultet, Beograd., 37(3), 58-65.
https://hdl.handle.net/21.15107/rcub_smile_1177

Leković V, Aleksić Z. The use of growth factors in regenerative periodontal surgery. in Medicinska istraživanja. 2003;37(3):58-65.
https://hdl.handle.net/21.15107/rcub_smile_1177 .

Leković, Vojislav, Aleksić, Zoran, "The use of growth factors in regenerative periodontal surgery" in Medicinska istraživanja, 37, no. 3 (2003):58-65,
https://hdl.handle.net/21.15107/rcub_smile_1177 .

TY  - THES
AU  - Leković, Vojislav
PY  - 1981
UR  - https://plus.sr.cobiss.net/opac7/bib/43666956
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/128
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Reparatorne sposobnosti parodoncijuma
UR  - https://hdl.handle.net/21.15107/rcub_smile_128
ER  - 

@phdthesis{
author = "Leković, Vojislav",
year = "1981",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Reparatorne sposobnosti parodoncijuma",
url = "https://hdl.handle.net/21.15107/rcub_smile_128"
}

Leković, V.. (1981). Reparatorne sposobnosti parodoncijuma. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_128

Leković V. Reparatorne sposobnosti parodoncijuma. 1981;.
https://hdl.handle.net/21.15107/rcub_smile_128 .

Leković, Vojislav, "Reparatorne sposobnosti parodoncijuma" (1981),
https://hdl.handle.net/21.15107/rcub_smile_128 .

TY  - THES
AU  - Leković, Vojislav
PY  - 1979
UR  - https://plus.sr.cobiss.net/opac7/bib/1024046734
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/112
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Proveravanje terapijskog efekta kod aftoznih lezija
UR  - https://hdl.handle.net/21.15107/rcub_smile_112
ER  - 

@mastersthesis{
author = "Leković, Vojislav",
year = "1979",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Proveravanje terapijskog efekta kod aftoznih lezija",
url = "https://hdl.handle.net/21.15107/rcub_smile_112"
}

Leković, V.. (1979). Proveravanje terapijskog efekta kod aftoznih lezija. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_112

Leković V. Proveravanje terapijskog efekta kod aftoznih lezija. 1979;.
https://hdl.handle.net/21.15107/rcub_smile_112 .

Leković, Vojislav, "Proveravanje terapijskog efekta kod aftoznih lezija" (1979),
https://hdl.handle.net/21.15107/rcub_smile_112 .