TY  - JOUR
AU  - De Colli, Marianna
AU  - Radunović, Milena
AU  - Zizzari, Vincenzo L.
AU  - Di Giacomo, Viviana
AU  - Di Nisio, Chiara
AU  - Piattelli, Adriano
AU  - Calvo Guirado, Jose Luis
AU  - Zavan, Barbara
AU  - Cataldi, Amelia
AU  - Zara, Susi
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2304
AB  - Titanium surface modification is critical for dental implant success. Our aim was to determine surfaces influence on dental pulp stem cells (DPSCs) viability and differentiation. Implants were divided into sandblasted/acid-etched (control) and sandblasted/acid-etched coated with calcium and magnesium ions (CaMg), supplied as composite (test). Proliferation was evaluated by MTT, differentiation checking osteoblastic gene expression, PGE2 secretion and matrix formation, inflammation by Interleukin 6 (IL-6) detection. MTT and IL-6 do not modify on test. A PGE2 increase on test is recorded. BMP2 is higher on test at early experimental points, Osterix and RUNX2 augment later. Alizarin-red S reveals higher matrix production on test. These results suggest that test surface is more osteoinductive, representing a start point for in vivo studies aiming at the construction of more biocompatible dental implants, whose integration and clinical performance are improved and some undesired effects, such as implant stability loss and further surgical procedures, are reduced.
PB  - Japanese Soc Dental Materials Devices, Tokyo
T2  - Dental Materials Journal
T1  - Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface
VL  - 37
IS  - 2
SP  - 197
EP  - 205
DO  - 10.4012/dmj.2016-418
ER  - 

@article{
author = "De Colli, Marianna and Radunović, Milena and Zizzari, Vincenzo L. and Di Giacomo, Viviana and Di Nisio, Chiara and Piattelli, Adriano and Calvo Guirado, Jose Luis and Zavan, Barbara and Cataldi, Amelia and Zara, Susi",
year = "2018",
abstract = "Titanium surface modification is critical for dental implant success. Our aim was to determine surfaces influence on dental pulp stem cells (DPSCs) viability and differentiation. Implants were divided into sandblasted/acid-etched (control) and sandblasted/acid-etched coated with calcium and magnesium ions (CaMg), supplied as composite (test). Proliferation was evaluated by MTT, differentiation checking osteoblastic gene expression, PGE2 secretion and matrix formation, inflammation by Interleukin 6 (IL-6) detection. MTT and IL-6 do not modify on test. A PGE2 increase on test is recorded. BMP2 is higher on test at early experimental points, Osterix and RUNX2 augment later. Alizarin-red S reveals higher matrix production on test. These results suggest that test surface is more osteoinductive, representing a start point for in vivo studies aiming at the construction of more biocompatible dental implants, whose integration and clinical performance are improved and some undesired effects, such as implant stability loss and further surgical procedures, are reduced.",
publisher = "Japanese Soc Dental Materials Devices, Tokyo",
journal = "Dental Materials Journal",
title = "Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface",
volume = "37",
number = "2",
pages = "197-205",
doi = "10.4012/dmj.2016-418"
}

De Colli, M., Radunović, M., Zizzari, V. L., Di Giacomo, V., Di Nisio, C., Piattelli, A., Calvo Guirado, J. L., Zavan, B., Cataldi, A.,& Zara, S.. (2018). Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface. in Dental Materials Journal
Japanese Soc Dental Materials Devices, Tokyo., 37(2), 197-205.
https://doi.org/10.4012/dmj.2016-418

De Colli M, Radunović M, Zizzari VL, Di Giacomo V, Di Nisio C, Piattelli A, Calvo Guirado JL, Zavan B, Cataldi A, Zara S. Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface. in Dental Materials Journal. 2018;37(2):197-205.
doi:10.4012/dmj.2016-418 .

De Colli, Marianna, Radunović, Milena, Zizzari, Vincenzo L., Di Giacomo, Viviana, Di Nisio, Chiara, Piattelli, Adriano, Calvo Guirado, Jose Luis, Zavan, Barbara, Cataldi, Amelia, Zara, Susi, "Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface" in Dental Materials Journal, 37, no. 2 (2018):197-205,
https://doi.org/10.4012/dmj.2016-418 . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Đinić, Ana
AU  - Calvo Guirado, Jose Luis
AU  - Tahmaseb, Ali
AU  - Šćepanović, Miodrag
AU  - Janjić, Bojan
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2214
AB  - ObjectivesTo compare the peri-implant bone healing between TiZr implants with hydrophilic SLActive and hydrophobic SLA implant surface in patients receiving anticoagulants, to assess the implant survival and success rate, as well as to evaluate whether small-diameter TiZr implants could be used in patients on OAT in order to avoid augmentation procedures. Material and methodsA total of 80 small-diameter tissue-level TiZr implants with SLActive and SLA surfaces were placed in 20 anticoagulated patients, following the split-mouth study design. Implant stability was measured up to the third postoperative month by resonance frequency measurements (RFA). One-year implant survival and success rate were evaluated. ResultsAfter one year, 100% implant survival and success rate were observed. A significant decrease in ISQ comparing to baseline values was noted in the SLActive group from the first postoperative week, and in the SLA group, from the 3rdweek after the surgery. In both groups, a statistically significant decline in ISQ was observed between second and third postoperative week. No significant differences in ISQ values between SLActive and SLA implants were noted, at any time point. ConclusionsTitanium-zirconium small-diameter implants with SLActive and SLA surface predictably achieve and maintain adequate bone tissue integration in patients receiving anticoagulants. OAT appears to influence the bone healing events resulting in lower ISQ in the end of 3-month period in comparison with baseline values, although without compromising implant stability.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants
VL  - 28
IS  - 10
SP  - 1241
EP  - 1247
DO  - 10.1111/clr.12948
ER  - 

@article{
author = "Marković, Aleksa and Đinić, Ana and Calvo Guirado, Jose Luis and Tahmaseb, Ali and Šćepanović, Miodrag and Janjić, Bojan",
year = "2017",
abstract = "ObjectivesTo compare the peri-implant bone healing between TiZr implants with hydrophilic SLActive and hydrophobic SLA implant surface in patients receiving anticoagulants, to assess the implant survival and success rate, as well as to evaluate whether small-diameter TiZr implants could be used in patients on OAT in order to avoid augmentation procedures. Material and methodsA total of 80 small-diameter tissue-level TiZr implants with SLActive and SLA surfaces were placed in 20 anticoagulated patients, following the split-mouth study design. Implant stability was measured up to the third postoperative month by resonance frequency measurements (RFA). One-year implant survival and success rate were evaluated. ResultsAfter one year, 100% implant survival and success rate were observed. A significant decrease in ISQ comparing to baseline values was noted in the SLActive group from the first postoperative week, and in the SLA group, from the 3rdweek after the surgery. In both groups, a statistically significant decline in ISQ was observed between second and third postoperative week. No significant differences in ISQ values between SLActive and SLA implants were noted, at any time point. ConclusionsTitanium-zirconium small-diameter implants with SLActive and SLA surface predictably achieve and maintain adequate bone tissue integration in patients receiving anticoagulants. OAT appears to influence the bone healing events resulting in lower ISQ in the end of 3-month period in comparison with baseline values, although without compromising implant stability.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants",
volume = "28",
number = "10",
pages = "1241-1247",
doi = "10.1111/clr.12948"
}

Marković, A., Đinić, A., Calvo Guirado, J. L., Tahmaseb, A., Šćepanović, M.,& Janjić, B.. (2017). Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants. in Clinical Oral Implants Research
Wiley, Hoboken., 28(10), 1241-1247.
https://doi.org/10.1111/clr.12948

Marković A, Đinić A, Calvo Guirado JL, Tahmaseb A, Šćepanović M, Janjić B. Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants. in Clinical Oral Implants Research. 2017;28(10):1241-1247.
doi:10.1111/clr.12948 .

Marković, Aleksa, Đinić, Ana, Calvo Guirado, Jose Luis, Tahmaseb, Ali, Šćepanović, Miodrag, Janjić, Bojan, "Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants" in Clinical Oral Implants Research, 28, no. 10 (2017):1241-1247,
https://doi.org/10.1111/clr.12948 . .

TY  - JOUR
AU  - Gehrke, Sergio A.
AU  - Perez-Albacete, Carlos
AU  - Martinez
AU  - Piattelli, Adriano
AU  - Shibli, Jamil A.
AU  - Marković, Aleksa
AU  - Calvo Guirado, Jose Luis
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2193
AB  - Objectives: The aim of this study was to perform a histomorphometric and biomechanical comparison of three implants with different designs of the apical area to promote a better bone initial stability and its correlation with the osseointegration. Material and methods: Fifty-four tapered implants with same length, diameter and surface properties but with three different apical configurations (Group I: MK4: Group II: C1 and Group III: MK7) were inserted in the tibia of rabbits. Implant stability and bone formation were evaluated by resonance frequency analysis measured at 0, 6, 8 and 12 weeks and by histomorphometric analysis performed at 6, 8 and 12 weeks. Results: Statistical test to compare the stability through the implant stability quotient in the four times showed few differences between the groups and time periods proposed, with significance set at P  lt  0.05. In the bone-implant contact, by comparing the groups in the three times proposed, it was possible concluded that there is a similar behavior among the three implant design (P  lt  0.05). Conclusion: With the limitations of this animal study, it can be concluded that the design of the apical area influences the implant stability and the bone-to-implant contact.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits
VL  - 28
IS  - 3
SP  - 355
EP  - 361
DO  - 10.1111/clr.12807
ER  - 

@article{
author = "Gehrke, Sergio A. and Perez-Albacete, Carlos and Martinez and Piattelli, Adriano and Shibli, Jamil A. and Marković, Aleksa and Calvo Guirado, Jose Luis",
year = "2017",
abstract = "Objectives: The aim of this study was to perform a histomorphometric and biomechanical comparison of three implants with different designs of the apical area to promote a better bone initial stability and its correlation with the osseointegration. Material and methods: Fifty-four tapered implants with same length, diameter and surface properties but with three different apical configurations (Group I: MK4: Group II: C1 and Group III: MK7) were inserted in the tibia of rabbits. Implant stability and bone formation were evaluated by resonance frequency analysis measured at 0, 6, 8 and 12 weeks and by histomorphometric analysis performed at 6, 8 and 12 weeks. Results: Statistical test to compare the stability through the implant stability quotient in the four times showed few differences between the groups and time periods proposed, with significance set at P  lt  0.05. In the bone-implant contact, by comparing the groups in the three times proposed, it was possible concluded that there is a similar behavior among the three implant design (P  lt  0.05). Conclusion: With the limitations of this animal study, it can be concluded that the design of the apical area influences the implant stability and the bone-to-implant contact.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits",
volume = "28",
number = "3",
pages = "355-361",
doi = "10.1111/clr.12807"
}

Gehrke, S. A., Perez-Albacete, C., Martinez, Piattelli, A., Shibli, J. A., Marković, A.,& Calvo Guirado, J. L.. (2017). The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits. in Clinical Oral Implants Research
Wiley, Hoboken., 28(3), 355-361.
https://doi.org/10.1111/clr.12807

Gehrke SA, Perez-Albacete C, Martinez, Piattelli A, Shibli JA, Marković A, Calvo Guirado JL. The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits. in Clinical Oral Implants Research. 2017;28(3):355-361.
doi:10.1111/clr.12807 .

Gehrke, Sergio A., Perez-Albacete, Carlos, Martinez, Piattelli, Adriano, Shibli, Jamil A., Marković, Aleksa, Calvo Guirado, Jose Luis, "The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits" in Clinical Oral Implants Research, 28, no. 3 (2017):355-361,
https://doi.org/10.1111/clr.12807 . .

TY  - JOUR
AU  - Calvo Guirado, Jose Luis
AU  - Ruiz, Rafael Arcesio Delgado
AU  - Piedad Ramirez-Fernandez, Maria
AU  - Abboud, Marcus
AU  - Janjić, Bojan
AU  - Sanchez de Val, Jose Eduardo Mate
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2143
AB  - BackgroundNarrow-diameter implants provide an alternative to the horizontal augmentation techniques situations severe bone atrophy. Lack of bone width and interdental space has been regarded as an encumbrance in the case selection for prosthetic rehabilitation using dental implants. ObjectiveThe aim of the study was to evaluate bone-to-implant contact and marginal bone loss of two different narrow implants in resorbed ridges at different crestal positions. Material and methods48 Bredent Narrow((R)) implants (24 MiniSky((R)) and NarowSky((R))) were placed at crestal and subcrestal levels in healing bone of atrophic alveolar ridge of 6 American foxhounds. Histological and histomorphometric analyses of osseointegration were carried out at 4 and 8weeks. ResultsModeling in the marginal defect region was accompanied by marked decreases in the dimensions of both the buccal and the more lingual bone walls. Relative to BIC, significant differences were found in favor of subcrestal group, for both Narrow Sky and MiniSky. Linear measurements showed to be slightly high in the crestal group. With significant differences for PM-IS (peri-implant mucosa to implant shoulder) and IS-BC (implant shoulder to buccal bone crest). ConclusionsWithin the limitations of animal study, it can be stated that the NarrowSky(test group) crestal and subcrestal implants showed less crestal bone resorption, higher ISQ values and most BIC at 4 and 8weeks of evaluation compared with MiniSky implants (control group). The design of the implants plays an important role in peri-implant mucosa and crestal bone maintenance at 8-week follow-up period.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - RETRACTED: Histological and histomorphometric analyses of narrow implants, crestal and subcrestally placed in severe alveolar atrophy: a study in foxhound dogs (Retracted article. See vol. 29, pg. 819, 2018)
VL  - 27
IS  - 4
SP  - 497
EP  - 504
DO  - 10.1111/clr.12569
ER  - 

@article{
author = "Calvo Guirado, Jose Luis and Ruiz, Rafael Arcesio Delgado and Piedad Ramirez-Fernandez, Maria and Abboud, Marcus and Janjić, Bojan and Sanchez de Val, Jose Eduardo Mate",
year = "2016",
abstract = "BackgroundNarrow-diameter implants provide an alternative to the horizontal augmentation techniques situations severe bone atrophy. Lack of bone width and interdental space has been regarded as an encumbrance in the case selection for prosthetic rehabilitation using dental implants. ObjectiveThe aim of the study was to evaluate bone-to-implant contact and marginal bone loss of two different narrow implants in resorbed ridges at different crestal positions. Material and methods48 Bredent Narrow((R)) implants (24 MiniSky((R)) and NarowSky((R))) were placed at crestal and subcrestal levels in healing bone of atrophic alveolar ridge of 6 American foxhounds. Histological and histomorphometric analyses of osseointegration were carried out at 4 and 8weeks. ResultsModeling in the marginal defect region was accompanied by marked decreases in the dimensions of both the buccal and the more lingual bone walls. Relative to BIC, significant differences were found in favor of subcrestal group, for both Narrow Sky and MiniSky. Linear measurements showed to be slightly high in the crestal group. With significant differences for PM-IS (peri-implant mucosa to implant shoulder) and IS-BC (implant shoulder to buccal bone crest). ConclusionsWithin the limitations of animal study, it can be stated that the NarrowSky(test group) crestal and subcrestal implants showed less crestal bone resorption, higher ISQ values and most BIC at 4 and 8weeks of evaluation compared with MiniSky implants (control group). The design of the implants plays an important role in peri-implant mucosa and crestal bone maintenance at 8-week follow-up period.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "RETRACTED: Histological and histomorphometric analyses of narrow implants, crestal and subcrestally placed in severe alveolar atrophy: a study in foxhound dogs (Retracted article. See vol. 29, pg. 819, 2018)",
volume = "27",
number = "4",
pages = "497-504",
doi = "10.1111/clr.12569"
}

Calvo Guirado, J. L., Ruiz, R. A. D., Piedad Ramirez-Fernandez, M., Abboud, M., Janjić, B.,& Sanchez de Val, J. E. M.. (2016). RETRACTED: Histological and histomorphometric analyses of narrow implants, crestal and subcrestally placed in severe alveolar atrophy: a study in foxhound dogs (Retracted article. See vol. 29, pg. 819, 2018). in Clinical Oral Implants Research
Wiley, Hoboken., 27(4), 497-504.
https://doi.org/10.1111/clr.12569

Calvo Guirado JL, Ruiz RAD, Piedad Ramirez-Fernandez M, Abboud M, Janjić B, Sanchez de Val JEM. RETRACTED: Histological and histomorphometric analyses of narrow implants, crestal and subcrestally placed in severe alveolar atrophy: a study in foxhound dogs (Retracted article. See vol. 29, pg. 819, 2018). in Clinical Oral Implants Research. 2016;27(4):497-504.
doi:10.1111/clr.12569 .

Calvo Guirado, Jose Luis, Ruiz, Rafael Arcesio Delgado, Piedad Ramirez-Fernandez, Maria, Abboud, Marcus, Janjić, Bojan, Sanchez de Val, Jose Eduardo Mate, "RETRACTED: Histological and histomorphometric analyses of narrow implants, crestal and subcrestally placed in severe alveolar atrophy: a study in foxhound dogs (Retracted article. See vol. 29, pg. 819, 2018)" in Clinical Oral Implants Research, 27, no. 4 (2016):497-504,
https://doi.org/10.1111/clr.12569 . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Mišić, Tijana
AU  - Calvo Guirado, Jose Luis
AU  - Delgado-Ruiz, Rafael
AU  - Janjić, Bojan
AU  - Abboud, Marcus
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2126
AB  - Purpose: To evaluate stability and success rate of hydrophilic nanostructured implants placed via osteotome sinus floor elevation (OSFE) without grafting material or using beta-tricalcium phosphate (beta-TCP), deproteinized bovine bone (DBB), or their combination, and also to assess three-dimensional volumetric stability of endo-sinus bone gained in the aforementioned conditions. Materials and Methods: OSFE with simultaneous implant placement (10-mm long SLActive-BL (R), Straumann, Basel, Switzerland) was performed. Grafting materials were randomly allocated to implant sites, whereas one site was left without graft. Implant stability was measured by resonance frequency analysis over 6 months. Implant success was evaluated after 2 years of loading. Volume of new endo-sinus bone was calculated from CBCT images using 3D Slicer (R) software. Results: A total of 180 implants were inserted into posterior maxilla of 45 patients with 6.59 +/- 0.45 mm of residual bone height, and all remained successful after 2 years. Implant stability steadily increased during healing, without significant difference between groups (p =.658). After 2 years, endo-sinus bone significantly shrank (p  lt .001) in all groups (DBB: 66.34%; beta-TCP: 61.44%; new bone formed from coagulum: 53.02%; beta-TCP + DBB: 33.47%). Conclusions: Endo-sinus bone gained after OSFE inevitably and significantly shrinks regardless of whether grafting material is applied or not. Grafting material offers no significant advantage to stability nor clinical success of hydrophilic and nanostructured implants placed simultaneously with OSFE.
PB  - Wiley, Hoboken
T2  - Clinical Implant Dentistry & Related Research
T1  - Two-Center Prospective, Randomized, Clinical, and Radiographic Study Comparing Osteotome Sinus Floor Elevation with or without Bone Graft and Simultaneous Implant Placement
VL  - 18
IS  - 5
SP  - 873
EP  - 882
DO  - 10.1111/cid.12373
ER  - 

@article{
author = "Marković, Aleksa and Mišić, Tijana and Calvo Guirado, Jose Luis and Delgado-Ruiz, Rafael and Janjić, Bojan and Abboud, Marcus",
year = "2016",
abstract = "Purpose: To evaluate stability and success rate of hydrophilic nanostructured implants placed via osteotome sinus floor elevation (OSFE) without grafting material or using beta-tricalcium phosphate (beta-TCP), deproteinized bovine bone (DBB), or their combination, and also to assess three-dimensional volumetric stability of endo-sinus bone gained in the aforementioned conditions. Materials and Methods: OSFE with simultaneous implant placement (10-mm long SLActive-BL (R), Straumann, Basel, Switzerland) was performed. Grafting materials were randomly allocated to implant sites, whereas one site was left without graft. Implant stability was measured by resonance frequency analysis over 6 months. Implant success was evaluated after 2 years of loading. Volume of new endo-sinus bone was calculated from CBCT images using 3D Slicer (R) software. Results: A total of 180 implants were inserted into posterior maxilla of 45 patients with 6.59 +/- 0.45 mm of residual bone height, and all remained successful after 2 years. Implant stability steadily increased during healing, without significant difference between groups (p =.658). After 2 years, endo-sinus bone significantly shrank (p  lt .001) in all groups (DBB: 66.34%; beta-TCP: 61.44%; new bone formed from coagulum: 53.02%; beta-TCP + DBB: 33.47%). Conclusions: Endo-sinus bone gained after OSFE inevitably and significantly shrinks regardless of whether grafting material is applied or not. Grafting material offers no significant advantage to stability nor clinical success of hydrophilic and nanostructured implants placed simultaneously with OSFE.",
publisher = "Wiley, Hoboken",
journal = "Clinical Implant Dentistry & Related Research",
title = "Two-Center Prospective, Randomized, Clinical, and Radiographic Study Comparing Osteotome Sinus Floor Elevation with or without Bone Graft and Simultaneous Implant Placement",
volume = "18",
number = "5",
pages = "873-882",
doi = "10.1111/cid.12373"
}

Marković, A., Mišić, T., Calvo Guirado, J. L., Delgado-Ruiz, R., Janjić, B.,& Abboud, M.. (2016). Two-Center Prospective, Randomized, Clinical, and Radiographic Study Comparing Osteotome Sinus Floor Elevation with or without Bone Graft and Simultaneous Implant Placement. in Clinical Implant Dentistry & Related Research
Wiley, Hoboken., 18(5), 873-882.
https://doi.org/10.1111/cid.12373

Marković A, Mišić T, Calvo Guirado JL, Delgado-Ruiz R, Janjić B, Abboud M. Two-Center Prospective, Randomized, Clinical, and Radiographic Study Comparing Osteotome Sinus Floor Elevation with or without Bone Graft and Simultaneous Implant Placement. in Clinical Implant Dentistry & Related Research. 2016;18(5):873-882.
doi:10.1111/cid.12373 .

Marković, Aleksa, Mišić, Tijana, Calvo Guirado, Jose Luis, Delgado-Ruiz, Rafael, Janjić, Bojan, Abboud, Marcus, "Two-Center Prospective, Randomized, Clinical, and Radiographic Study Comparing Osteotome Sinus Floor Elevation with or without Bone Graft and Simultaneous Implant Placement" in Clinical Implant Dentistry & Related Research, 18, no. 5 (2016):873-882,
https://doi.org/10.1111/cid.12373 . .

TY  - JOUR
AU  - Delgado-Ruiz, Rafael
AU  - Gomez-Moreno, Gerardo
AU  - Aguilar-Salvatierra, Antonio
AU  - Marković, Aleksa
AU  - Eduardo Mate-Sanchez, Jose
AU  - Calvo Guirado, Jose Luis
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2125
AB  - ObjectivesTo measure the lateral surface area of microgrooved zirconia implants, to evaluate the cell geometry and cell density of human fetal osteoblasts seeded on zirconia microgrooved implants, to describe the surface roughness and chemistry, and to evaluate the activity of human fetal osteoblasts seeded on zirconia microgrooved disks. Materials and methodsThis experimental in vitro study used 62 zirconia implants and 130 zirconia disks. Two experimental groups were created for the implants: 31 non-microgrooved implants (Control) and 31 microgrooved implants (Test); two experimental groups were created for the disks: 65 non-microgrooved disks (Control) and 65 microgrooved disks (Test). The following evaluations of the implants were made: lateral surface area (LSA), cell morphology, and density of human fetal osteoblasts seeded on implant surfaces. On the disks, surface parameters (roughness and chemistry) and cell activity (alkaline phosphatase - ALP and alizarin red - ALZ) were evaluated at 7 and 15days. ResultsLSA was lower for control implants (62.8mm) compared with test implants (128.74mm) (P lt 0.05). Cell bodies on control surfaces were flattened and disorganized, while in the test group, they were aligned inside the microgrooves. Control group cells showed few lamellipodia, which were attached mainly inside topographical accidents (surface cracks, valleys, and pits). Test group implants presented cells rich in lamellipodia prolongations, attached to the inner walls or to the borders of the microgrooves and in the flat areas between the microgrooves. Cell density was higher in the test group compared with controls (P lt 0.05) Surface roughness and oxygen content increased in test disks samples compared with controls (P lt 0.05). Carbon and aluminum were reduced in disks test samples compared with controls (P lt 0.05), and ALP and ALZ levels were significantly increased on test surfaces (P lt 0.05) at both study times. ConclusionsWithin the limitations of this experimental study, it may be concluded that (i) Roughness is increased and chemical composition enhanced on the surface of zirconia implants with microgrooves. (ii) The LSA of microgrooved zirconia implants is greater and provides more available surface compared with implants of the same dimensions without microgrooves. (iii) Microgrooves on zirconia implants modify the morphology and guide the size and alignment of human fetal osteoblasts. (iv) Zirconia surfaces with microgrooves of 30m width and 70m separation between grooves enhance ALP and ALZ expression by human fetal osteoblasts.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimental in vitro study
VL  - 27
IS  - 11
SP  - e144
EP  - e153
DO  - 10.1111/clr.12585
ER  - 

@article{
author = "Delgado-Ruiz, Rafael and Gomez-Moreno, Gerardo and Aguilar-Salvatierra, Antonio and Marković, Aleksa and Eduardo Mate-Sanchez, Jose and Calvo Guirado, Jose Luis",
year = "2016",
abstract = "ObjectivesTo measure the lateral surface area of microgrooved zirconia implants, to evaluate the cell geometry and cell density of human fetal osteoblasts seeded on zirconia microgrooved implants, to describe the surface roughness and chemistry, and to evaluate the activity of human fetal osteoblasts seeded on zirconia microgrooved disks. Materials and methodsThis experimental in vitro study used 62 zirconia implants and 130 zirconia disks. Two experimental groups were created for the implants: 31 non-microgrooved implants (Control) and 31 microgrooved implants (Test); two experimental groups were created for the disks: 65 non-microgrooved disks (Control) and 65 microgrooved disks (Test). The following evaluations of the implants were made: lateral surface area (LSA), cell morphology, and density of human fetal osteoblasts seeded on implant surfaces. On the disks, surface parameters (roughness and chemistry) and cell activity (alkaline phosphatase - ALP and alizarin red - ALZ) were evaluated at 7 and 15days. ResultsLSA was lower for control implants (62.8mm) compared with test implants (128.74mm) (P lt 0.05). Cell bodies on control surfaces were flattened and disorganized, while in the test group, they were aligned inside the microgrooves. Control group cells showed few lamellipodia, which were attached mainly inside topographical accidents (surface cracks, valleys, and pits). Test group implants presented cells rich in lamellipodia prolongations, attached to the inner walls or to the borders of the microgrooves and in the flat areas between the microgrooves. Cell density was higher in the test group compared with controls (P lt 0.05) Surface roughness and oxygen content increased in test disks samples compared with controls (P lt 0.05). Carbon and aluminum were reduced in disks test samples compared with controls (P lt 0.05), and ALP and ALZ levels were significantly increased on test surfaces (P lt 0.05) at both study times. ConclusionsWithin the limitations of this experimental study, it may be concluded that (i) Roughness is increased and chemical composition enhanced on the surface of zirconia implants with microgrooves. (ii) The LSA of microgrooved zirconia implants is greater and provides more available surface compared with implants of the same dimensions without microgrooves. (iii) Microgrooves on zirconia implants modify the morphology and guide the size and alignment of human fetal osteoblasts. (iv) Zirconia surfaces with microgrooves of 30m width and 70m separation between grooves enhance ALP and ALZ expression by human fetal osteoblasts.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimental in vitro study",
volume = "27",
number = "11",
pages = "e144-e153",
doi = "10.1111/clr.12585"
}

Delgado-Ruiz, R., Gomez-Moreno, G., Aguilar-Salvatierra, A., Marković, A., Eduardo Mate-Sanchez, J.,& Calvo Guirado, J. L.. (2016). Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimental in vitro study. in Clinical Oral Implants Research
Wiley, Hoboken., 27(11), e144-e153.
https://doi.org/10.1111/clr.12585

Delgado-Ruiz R, Gomez-Moreno G, Aguilar-Salvatierra A, Marković A, Eduardo Mate-Sanchez J, Calvo Guirado JL. Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimental in vitro study. in Clinical Oral Implants Research. 2016;27(11):e144-e153.
doi:10.1111/clr.12585 .

Delgado-Ruiz, Rafael, Gomez-Moreno, Gerardo, Aguilar-Salvatierra, Antonio, Marković, Aleksa, Eduardo Mate-Sanchez, Jose, Calvo Guirado, Jose Luis, "Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimental in vitro study" in Clinical Oral Implants Research, 27, no. 11 (2016):e144-e153,
https://doi.org/10.1111/clr.12585 . .

TY  - JOUR
AU  - Perez-Albacete Martinez, Carlos
AU  - Vlahović, Zoran
AU  - Šćepanović, Miodrag
AU  - Videnović, Goran
AU  - Barone, Antonio
AU  - Calvo Guirado, Jose Luis
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2095
AB  - ObjectivesThe aim of our study was to compare osseointegration and peri-implant crestal bone resorption in submerged flapless and conventional flap surgery over a 12-month follow-up. Materials and methodsThe study used five domestic pigs. Implants were inserted 9weeks after tooth extraction. Each animal received six implants in the mandible, following a split-mouth design: one side was treated using a flapless technique using mini-incisions, while a flap was raised on the other. The animals were sacrificed at 2weeks, 1, 3, 6 and 12months after implant placement. Radiographic images were taken to analyze crestal bone loss, and samples were extracted for histopathological and bone-to-implant contact (BIC) analyses. ResultsSignificantly, greater crestal bone loss (P=0.005) was obtained in the flap group compared with the flapless group. The flapless group presented significantly higher percentages of BIC (P lt 0.05) at 3, 6 and 12months compared with the conventional flap group. ConclusionsWithin the limitations of this experimental animal study, it may be concluded that the type of surgery (flap or flapless) affects peri-implant bone preservation and osseointegration of regular platform implants. Flapless surgery is associated with peri-implant crestal bone preservation. Flapless surgery in combination with submerged implants allows higher osseointegration values.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical Oral Implants Research
T1  - Submerged flapless technique vs. conventional flap approach for implant placement: experimental domestic pig study with 12-month follow-up
VL  - 27
IS  - 8
SP  - 964
EP  - 968
DO  - 10.1111/clr.12665
ER  - 

@article{
author = "Perez-Albacete Martinez, Carlos and Vlahović, Zoran and Šćepanović, Miodrag and Videnović, Goran and Barone, Antonio and Calvo Guirado, Jose Luis",
year = "2016",
abstract = "ObjectivesThe aim of our study was to compare osseointegration and peri-implant crestal bone resorption in submerged flapless and conventional flap surgery over a 12-month follow-up. Materials and methodsThe study used five domestic pigs. Implants were inserted 9weeks after tooth extraction. Each animal received six implants in the mandible, following a split-mouth design: one side was treated using a flapless technique using mini-incisions, while a flap was raised on the other. The animals were sacrificed at 2weeks, 1, 3, 6 and 12months after implant placement. Radiographic images were taken to analyze crestal bone loss, and samples were extracted for histopathological and bone-to-implant contact (BIC) analyses. ResultsSignificantly, greater crestal bone loss (P=0.005) was obtained in the flap group compared with the flapless group. The flapless group presented significantly higher percentages of BIC (P lt 0.05) at 3, 6 and 12months compared with the conventional flap group. ConclusionsWithin the limitations of this experimental animal study, it may be concluded that the type of surgery (flap or flapless) affects peri-implant bone preservation and osseointegration of regular platform implants. Flapless surgery is associated with peri-implant crestal bone preservation. Flapless surgery in combination with submerged implants allows higher osseointegration values.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Submerged flapless technique vs. conventional flap approach for implant placement: experimental domestic pig study with 12-month follow-up",
volume = "27",
number = "8",
pages = "964-968",
doi = "10.1111/clr.12665"
}

Perez-Albacete Martinez, C., Vlahović, Z., Šćepanović, M., Videnović, G., Barone, A.,& Calvo Guirado, J. L.. (2016). Submerged flapless technique vs. conventional flap approach for implant placement: experimental domestic pig study with 12-month follow-up. in Clinical Oral Implants Research
Wiley-Blackwell, Hoboken., 27(8), 964-968.
https://doi.org/10.1111/clr.12665

Perez-Albacete Martinez C, Vlahović Z, Šćepanović M, Videnović G, Barone A, Calvo Guirado JL. Submerged flapless technique vs. conventional flap approach for implant placement: experimental domestic pig study with 12-month follow-up. in Clinical Oral Implants Research. 2016;27(8):964-968.
doi:10.1111/clr.12665 .

Perez-Albacete Martinez, Carlos, Vlahović, Zoran, Šćepanović, Miodrag, Videnović, Goran, Barone, Antonio, Calvo Guirado, Jose Luis, "Submerged flapless technique vs. conventional flap approach for implant placement: experimental domestic pig study with 12-month follow-up" in Clinical Oral Implants Research, 27, no. 8 (2016):964-968,
https://doi.org/10.1111/clr.12665 . .

TY  - JOUR
AU  - Gomez-Moreno, Gerardo
AU  - Aguilar-Salvatierra, Antonio
AU  - Fernandez-Cejas, Esther
AU  - Arcesio Delgado-Ruiz, Rafael
AU  - Marković, Aleksa
AU  - Calvo Guirado, Jose Luis
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2088
AB  - Objectives: The aim of this study was to evaluate the incidence of bleeding complications after dental implant placement in patients in treatment by the anticoagulant oral rivaroxaban without interrupting its administration or modifying dosage. Materials and methods: About 57 patients were divided into two groups: 18 had been in treatment by rivaroxaban for over 6 month before implant surgery and a control group consisted of 39 healthy subjects. All subjects received dental implants in different positions, without interrupting or modifying rivaroxaban dosage. Patients were treated in an outpatient setting. Non-absorbable sutures were used, and all patients were given gauze impregnated with tranexamic acid 5%, to bite on for 30 60 min. Results: One rivaroxaban patient presented moderate bleeding the day after surgery, and two control patients presented moderate bleeding the day after and on the second day. Bleeding was managed with gauzes impregnated with tranexamic acid. No statistically significant differences (P 0.688) were found in relation to bleeding episodes between the groups, with a relative risk 0.919 based on the pooled groups and 95% confidence interval of 0.078 10.844. Conclusions: Dental implant surgery in patients taking the anticoagulant oral rivaroxaban can be performed safely in outpatients departments applying local hemostatic measures without the need to modify or interrupt anticoagulant medication.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban
VL  - 27
IS  - 6
SP  - 730
EP  - 733
DO  - 10.1111/clr.12653
ER  - 

@article{
author = "Gomez-Moreno, Gerardo and Aguilar-Salvatierra, Antonio and Fernandez-Cejas, Esther and Arcesio Delgado-Ruiz, Rafael and Marković, Aleksa and Calvo Guirado, Jose Luis",
year = "2016",
abstract = "Objectives: The aim of this study was to evaluate the incidence of bleeding complications after dental implant placement in patients in treatment by the anticoagulant oral rivaroxaban without interrupting its administration or modifying dosage. Materials and methods: About 57 patients were divided into two groups: 18 had been in treatment by rivaroxaban for over 6 month before implant surgery and a control group consisted of 39 healthy subjects. All subjects received dental implants in different positions, without interrupting or modifying rivaroxaban dosage. Patients were treated in an outpatient setting. Non-absorbable sutures were used, and all patients were given gauze impregnated with tranexamic acid 5%, to bite on for 30 60 min. Results: One rivaroxaban patient presented moderate bleeding the day after surgery, and two control patients presented moderate bleeding the day after and on the second day. Bleeding was managed with gauzes impregnated with tranexamic acid. No statistically significant differences (P 0.688) were found in relation to bleeding episodes between the groups, with a relative risk 0.919 based on the pooled groups and 95% confidence interval of 0.078 10.844. Conclusions: Dental implant surgery in patients taking the anticoagulant oral rivaroxaban can be performed safely in outpatients departments applying local hemostatic measures without the need to modify or interrupt anticoagulant medication.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban",
volume = "27",
number = "6",
pages = "730-733",
doi = "10.1111/clr.12653"
}

Gomez-Moreno, G., Aguilar-Salvatierra, A., Fernandez-Cejas, E., Arcesio Delgado-Ruiz, R., Marković, A.,& Calvo Guirado, J. L.. (2016). Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban. in Clinical Oral Implants Research
Wiley, Hoboken., 27(6), 730-733.
https://doi.org/10.1111/clr.12653

Gomez-Moreno G, Aguilar-Salvatierra A, Fernandez-Cejas E, Arcesio Delgado-Ruiz R, Marković A, Calvo Guirado JL. Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban. in Clinical Oral Implants Research. 2016;27(6):730-733.
doi:10.1111/clr.12653 .

Gomez-Moreno, Gerardo, Aguilar-Salvatierra, Antonio, Fernandez-Cejas, Esther, Arcesio Delgado-Ruiz, Rafael, Marković, Aleksa, Calvo Guirado, Jose Luis, "Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban" in Clinical Oral Implants Research, 27, no. 6 (2016):730-733,
https://doi.org/10.1111/clr.12653 . .

TY  - JOUR
AU  - Delgado-Ruiz, Rafael
AU  - Calvo Guirado, Jose Luis
AU  - Abboud, Marcus
AU  - Piedad Ramirez-Fernandez, Maria
AU  - Eduardo Mate-Sanchez, Jose
AU  - Negri, Bruno
AU  - Gomez-Moreno, Gerardo
AU  - Marković, Aleksa
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1970
AB  - PurposeTo describe contact, thickness, density, and orientation of connective tissue fibers around healing abutments of different geometries by means of a new method using coordinates. Materials and MethodsFollowing the bilateral extraction of mandibular premolars (P2, P3, and P4) from six fox hound dogs and a 2-month healing period, 36 titanium implants were inserted, onto which two groups of healing abutments of different geometry were screwed: Group A (concave abutments) and Group B (wider healing abutment). After 3 months the animals were sacrificed and samples extracted containing each implant and surrounding soft and hard tissues. Histological analysis was performed without decalcifying the samples by means of circularly polarized light under optical microscope and a system of vertical and horizontal coordinates across all the connective tissue in an area delimited by the implant/abutment, epithelium, and bone tissue. ResultsIn no case had the connective tissue formed a connection to the healing abutment/implant in the internal zone; a space of 3510m separated the connective tissue fibers from the healing abutment surface. The total thickness of connective tissue in the horizontal direction was significantly greater in the medial zone in Group B than in Group A (p lt .05). The orientation of the fibers varied according to the coordinate area so that internal coordinates showed a higher percentage of parallel fibers in Group A (p lt .05) and a higher percentage of oblique fibers in Group B (p lt .05); medial coordinates showed more oblique fibers (p lt .05); and the area of external coordinates showed the highest percentage of perpendicular fibers (p lt .05). The fiber density was higher in the basal and medial areas (p lt .05). ConclusionsAbutment geometry influences the orientation of collagen fibers; therefore, an abutment with a profile wider than the implant platform favors oblique and perpendicular orientation of collagen fibers and greater connective tissue thickness.
PB  - Wiley, Hoboken
T2  - Clinical Implant Dentistry & Related Research
T1  - Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light
VL  - 17
IS  - 4
SP  - 667
EP  - 680
DO  - 10.1111/cid.12161
ER  - 

@article{
author = "Delgado-Ruiz, Rafael and Calvo Guirado, Jose Luis and Abboud, Marcus and Piedad Ramirez-Fernandez, Maria and Eduardo Mate-Sanchez, Jose and Negri, Bruno and Gomez-Moreno, Gerardo and Marković, Aleksa",
year = "2015",
abstract = "PurposeTo describe contact, thickness, density, and orientation of connective tissue fibers around healing abutments of different geometries by means of a new method using coordinates. Materials and MethodsFollowing the bilateral extraction of mandibular premolars (P2, P3, and P4) from six fox hound dogs and a 2-month healing period, 36 titanium implants were inserted, onto which two groups of healing abutments of different geometry were screwed: Group A (concave abutments) and Group B (wider healing abutment). After 3 months the animals were sacrificed and samples extracted containing each implant and surrounding soft and hard tissues. Histological analysis was performed without decalcifying the samples by means of circularly polarized light under optical microscope and a system of vertical and horizontal coordinates across all the connective tissue in an area delimited by the implant/abutment, epithelium, and bone tissue. ResultsIn no case had the connective tissue formed a connection to the healing abutment/implant in the internal zone; a space of 3510m separated the connective tissue fibers from the healing abutment surface. The total thickness of connective tissue in the horizontal direction was significantly greater in the medial zone in Group B than in Group A (p lt .05). The orientation of the fibers varied according to the coordinate area so that internal coordinates showed a higher percentage of parallel fibers in Group A (p lt .05) and a higher percentage of oblique fibers in Group B (p lt .05); medial coordinates showed more oblique fibers (p lt .05); and the area of external coordinates showed the highest percentage of perpendicular fibers (p lt .05). The fiber density was higher in the basal and medial areas (p lt .05). ConclusionsAbutment geometry influences the orientation of collagen fibers; therefore, an abutment with a profile wider than the implant platform favors oblique and perpendicular orientation of collagen fibers and greater connective tissue thickness.",
publisher = "Wiley, Hoboken",
journal = "Clinical Implant Dentistry & Related Research",
title = "Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light",
volume = "17",
number = "4",
pages = "667-680",
doi = "10.1111/cid.12161"
}

Delgado-Ruiz, R., Calvo Guirado, J. L., Abboud, M., Piedad Ramirez-Fernandez, M., Eduardo Mate-Sanchez, J., Negri, B., Gomez-Moreno, G.,& Marković, A.. (2015). Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light. in Clinical Implant Dentistry & Related Research
Wiley, Hoboken., 17(4), 667-680.
https://doi.org/10.1111/cid.12161

Delgado-Ruiz R, Calvo Guirado JL, Abboud M, Piedad Ramirez-Fernandez M, Eduardo Mate-Sanchez J, Negri B, Gomez-Moreno G, Marković A. Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light. in Clinical Implant Dentistry & Related Research. 2015;17(4):667-680.
doi:10.1111/cid.12161 .

Delgado-Ruiz, Rafael, Calvo Guirado, Jose Luis, Abboud, Marcus, Piedad Ramirez-Fernandez, Maria, Eduardo Mate-Sanchez, Jose, Negri, Bruno, Gomez-Moreno, Gerardo, Marković, Aleksa, "Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light" in Clinical Implant Dentistry & Related Research, 17, no. 4 (2015):667-680,
https://doi.org/10.1111/cid.12161 . .

TY  - JOUR
AU  - Delgado-Ruiz, Rafael
AU  - Marković, Aleksa
AU  - Calvo Guirado, Jose Luis
AU  - Lazić, Zoran
AU  - Piattelli, Adriano
AU  - Boticelli, Daniele
AU  - Maté-Sánchez, José Eduardo
AU  - Negri, Bruno
AU  - Ramírez-Fernández, María Piedad
AU  - Mišić, Tijana
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1900
AB  - Background/Aim. The modification of implant surfaces could affect mechanical implant stability as well as dynamics and quality of peri-implant bone healing. The aim of this 3-month experimental study in dogs was to investigate implant stability, marginal bone levels and bone tissue response to zirconia dental implants with two laser-micro-grooved intraosseous surfaces in comparison with nongrooved sandblasted zirconia and sandblasted, high-temperature etched titanium implants. Methods. Implant surface characterization was performed using optical interferometric profilometry and energy dispersive X-ray spectroscopy. A total of 96 implants (4 mm in diameter and 10 mm in length) were inserted randomly in both sides of the lower jaw of 12 Fox Hound dogs divided into groups of 24 each: the control (titanium), the group A (sandblasted zirconia), the group B (sandblasted zirconia plus microgrooved neck) and the group C (sandblasted zirconia plus all microgrooved). All the implants were immediately loaded. Insertion torque, periotest values, radiographic crestal bone level and removal torque were recorded during the 3-month follow-up. Qualitative scanning electon microscope (SEM) analysis of the bone-implant interfaces of each group was performed. Results. Insertion torque values were higher in the group C and control implants (p  lt  0.05). Periotest values increased in all the periods in proportion to the extent of microgrooving as follows: the group C > the control > the group B > the group A (p  lt  0.05). Radiographic measurements showed minimal crestal bone loss at 3 months for microgrooved zirconia implants (groups C and B) and control implants compared with the group A implants (p  lt  0.05). The removal torque values increased with time for all the groups as follows: the group C > the control > the group B > the group A (p  lt  0.05). SEM showed that implant surfaces of the groups B and C had an extra bone growth inside the microgrooves that corresponded to the shape and direction of the microgrooves. Conclusion. The addition of microgrooves to the entire intraosseous surface of zirconia dental implants enhances primary and secondary implant stability, promotes bone tissue in growth and preserves crestal bone levels.
AB  - Uvod/Cilj. Modifikacija površine implantata može uticati na njegovu mehaničku stabilnost kao i na dinamiku i kvalitet periimplantatnog koštanog zarastanja. Cilj ove tromesečne eksperimentalne studije na psima bio je da se ispita stabilnost implantata, nivo marginalne kosti i odgovor koštanog tkiva na cirkonijum endoosealne implantate sa dve intraosealne površine mikrostrukturirane laserom u poređenju sa peskiranim cirkonijum implantatima čija površina nije mikrostrukturirana kao i sa titanijum implantatima čije su površine peskirane i nagrižene visokom temperaturom. Metode. Karakterizacija površine implantata učinjena je optičkom interferometrijskom profilometrijom i analizom energetskog spektra pri difrakciji X-zračenja. Ukupno 96 implantata (prečnika 4 mm i dužine 10 mm) ugrađeno je nasumično i obostrano u donju vilicu kod 12 pasa (lisičara) i podeljeno u četiri grupe po 24: kontrolna (titanijum implantati); grupa A (peskirani cirkonijum implantati); grupa B (peskirani cirkonijum implantati sa mikrokanalima u koronarnoj trećini); grupa C (peskirani cirkonijum implantati sa mikrokanalima duž cele površine). Svi implantati su odmah opterećeni. Meren je obrtni momenat pri ugradnji implantata, vrednosti periotesta, radiografski nivo marginalne kosti i obrtni moment za uklanjanje implantata tokom tromesečnog perioda praćenja. Međuspoj kosti i implantata iz svake grupe ispitivan je kvalitativnom skenirajućom elektronskom mikroskopijom (SEM). Rezultati. Veći obrtni momenat zabeležen je pri ugradnji implantata kod grupe C i kontrolne grupe (p  lt  0,05). U ispitivanom vremenskom periodu, vrednosti periotesta uvećavale su se srazmerno obimu mikrostrukturiranja površine i to: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Radiografskom analizom utvrđen je minimalni gubitak marginalne kosti u trećem mesecu praćenja oko cirkonijum implantata sa mikrokanalima (grupa B i C) i kontrola u poređenju sa implantatima grupe A (p  lt  0,05). Vrednosti obrtnog momenta za uklanjanje implantata vremenom su se uvećavale u svim grupama na sledeći način: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Kod implantatnih površina grupa B i C, SEM je pokazala dodatni rast koštanog tkiva unutar mikrokanala koji odgovara njihovom obliku i pravcu. Zaključak. Formiranje mikrokanala duž cele intraosealne površine cirkonijum endoosealnih implantata povećava primarnu i sekundarnu implantatnu stabilnost, podstiče urastanje koštanog tkiva i održava nivo marginalne kosti.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs
T1  - Implantatna stabilnost i nivo marginalne kosti kod cirkonijum endoosealnih implantata sa mikrostrukturiranom površinom - tromesečna eksperimentalna studija na psima
VL  - 71
IS  - 5
SP  - 451
EP  - 461
DO  - 10.2298/VSP121003034D
ER  - 

@article{
author = "Delgado-Ruiz, Rafael and Marković, Aleksa and Calvo Guirado, Jose Luis and Lazić, Zoran and Piattelli, Adriano and Boticelli, Daniele and Maté-Sánchez, José Eduardo and Negri, Bruno and Ramírez-Fernández, María Piedad and Mišić, Tijana",
year = "2014",
abstract = "Background/Aim. The modification of implant surfaces could affect mechanical implant stability as well as dynamics and quality of peri-implant bone healing. The aim of this 3-month experimental study in dogs was to investigate implant stability, marginal bone levels and bone tissue response to zirconia dental implants with two laser-micro-grooved intraosseous surfaces in comparison with nongrooved sandblasted zirconia and sandblasted, high-temperature etched titanium implants. Methods. Implant surface characterization was performed using optical interferometric profilometry and energy dispersive X-ray spectroscopy. A total of 96 implants (4 mm in diameter and 10 mm in length) were inserted randomly in both sides of the lower jaw of 12 Fox Hound dogs divided into groups of 24 each: the control (titanium), the group A (sandblasted zirconia), the group B (sandblasted zirconia plus microgrooved neck) and the group C (sandblasted zirconia plus all microgrooved). All the implants were immediately loaded. Insertion torque, periotest values, radiographic crestal bone level and removal torque were recorded during the 3-month follow-up. Qualitative scanning electon microscope (SEM) analysis of the bone-implant interfaces of each group was performed. Results. Insertion torque values were higher in the group C and control implants (p  lt  0.05). Periotest values increased in all the periods in proportion to the extent of microgrooving as follows: the group C > the control > the group B > the group A (p  lt  0.05). Radiographic measurements showed minimal crestal bone loss at 3 months for microgrooved zirconia implants (groups C and B) and control implants compared with the group A implants (p  lt  0.05). The removal torque values increased with time for all the groups as follows: the group C > the control > the group B > the group A (p  lt  0.05). SEM showed that implant surfaces of the groups B and C had an extra bone growth inside the microgrooves that corresponded to the shape and direction of the microgrooves. Conclusion. The addition of microgrooves to the entire intraosseous surface of zirconia dental implants enhances primary and secondary implant stability, promotes bone tissue in growth and preserves crestal bone levels., Uvod/Cilj. Modifikacija površine implantata može uticati na njegovu mehaničku stabilnost kao i na dinamiku i kvalitet periimplantatnog koštanog zarastanja. Cilj ove tromesečne eksperimentalne studije na psima bio je da se ispita stabilnost implantata, nivo marginalne kosti i odgovor koštanog tkiva na cirkonijum endoosealne implantate sa dve intraosealne površine mikrostrukturirane laserom u poređenju sa peskiranim cirkonijum implantatima čija površina nije mikrostrukturirana kao i sa titanijum implantatima čije su površine peskirane i nagrižene visokom temperaturom. Metode. Karakterizacija površine implantata učinjena je optičkom interferometrijskom profilometrijom i analizom energetskog spektra pri difrakciji X-zračenja. Ukupno 96 implantata (prečnika 4 mm i dužine 10 mm) ugrađeno je nasumično i obostrano u donju vilicu kod 12 pasa (lisičara) i podeljeno u četiri grupe po 24: kontrolna (titanijum implantati); grupa A (peskirani cirkonijum implantati); grupa B (peskirani cirkonijum implantati sa mikrokanalima u koronarnoj trećini); grupa C (peskirani cirkonijum implantati sa mikrokanalima duž cele površine). Svi implantati su odmah opterećeni. Meren je obrtni momenat pri ugradnji implantata, vrednosti periotesta, radiografski nivo marginalne kosti i obrtni moment za uklanjanje implantata tokom tromesečnog perioda praćenja. Međuspoj kosti i implantata iz svake grupe ispitivan je kvalitativnom skenirajućom elektronskom mikroskopijom (SEM). Rezultati. Veći obrtni momenat zabeležen je pri ugradnji implantata kod grupe C i kontrolne grupe (p  lt  0,05). U ispitivanom vremenskom periodu, vrednosti periotesta uvećavale su se srazmerno obimu mikrostrukturiranja površine i to: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Radiografskom analizom utvrđen je minimalni gubitak marginalne kosti u trećem mesecu praćenja oko cirkonijum implantata sa mikrokanalima (grupa B i C) i kontrola u poređenju sa implantatima grupe A (p  lt  0,05). Vrednosti obrtnog momenta za uklanjanje implantata vremenom su se uvećavale u svim grupama na sledeći način: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Kod implantatnih površina grupa B i C, SEM je pokazala dodatni rast koštanog tkiva unutar mikrokanala koji odgovara njihovom obliku i pravcu. Zaključak. Formiranje mikrokanala duž cele intraosealne površine cirkonijum endoosealnih implantata povećava primarnu i sekundarnu implantatnu stabilnost, podstiče urastanje koštanog tkiva i održava nivo marginalne kosti.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs, Implantatna stabilnost i nivo marginalne kosti kod cirkonijum endoosealnih implantata sa mikrostrukturiranom površinom - tromesečna eksperimentalna studija na psima",
volume = "71",
number = "5",
pages = "451-461",
doi = "10.2298/VSP121003034D"
}

Delgado-Ruiz, R., Marković, A., Calvo Guirado, J. L., Lazić, Z., Piattelli, A., Boticelli, D., Maté-Sánchez, J. E., Negri, B., Ramírez-Fernández, M. P.,& Mišić, T.. (2014). Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(5), 451-461.
https://doi.org/10.2298/VSP121003034D

Delgado-Ruiz R, Marković A, Calvo Guirado JL, Lazić Z, Piattelli A, Boticelli D, Maté-Sánchez JE, Negri B, Ramírez-Fernández MP, Mišić T. Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs. in Vojnosanitetski pregled. 2014;71(5):451-461.
doi:10.2298/VSP121003034D .

Delgado-Ruiz, Rafael, Marković, Aleksa, Calvo Guirado, Jose Luis, Lazić, Zoran, Piattelli, Adriano, Boticelli, Daniele, Maté-Sánchez, José Eduardo, Negri, Bruno, Ramírez-Fernández, María Piedad, Mišić, Tijana, "Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs" in Vojnosanitetski pregled, 71, no. 5 (2014):451-461,
https://doi.org/10.2298/VSP121003034D . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Mišić, Tijana
AU  - Miličić, Biljana
AU  - Calvo Guirado, Jose Luis
AU  - Aleksić, Zoran
AU  - Đinić, Ana
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1830
AB  - Objectives The study aimed to investigate the effect of surgical technique, implant macrodesign and insertion torque on bone temperature changes during implant placement. Material and methods In the in vitro study, 144 self-tapping (blueSKY (R) 4x10mm; Bredent) and 144 non-self-tapping (Standard implant (R) 4.1x10mm; Straumann) were placed in osteotomies prepared in pig ribs by lateral bone condensing or bone drilling techniques. The maximum insertion torque values of 30, 35 and 40Ncm were used. Real-time bone temperature measurement during implant placement was performed by three thermocouples positioned vertically, in tripod configuration around every osteotomy, at a distance of 5mm from it and at depths of 1, 5 and 10mm. Data were analysed using Kruskal-Wallis, Mann-Whitney U-tests and Regression analysis. Results Significant predictor of bone temperature at the osteotomy depth of 1mm was insertion torque (P=0.003) and at the depth of 10-mm implant macrodesign (P=0.029), while no significant predictor at depth of 5mm was identified (0.05). Higher insertion torque values as well as non-self-tapping implant macrodesign were related to higher temperatures. Implant placement in sites prepared by bone drilling induced significantly higher temperature increase (P=0.021) compared with bone condensing sites at the depth of 5mm, while no significant difference was recorded at other depths. Compared with 30Ncm, insertion torque values of 35 and 40Ncm produced significantly higher temperature increase (P=0.005; P=0.003, respectively) at the depth of 1mm. There was no significant difference in temperature change induced by 35 and 40Ncm, neither by implant macrodesign at all investigated depths (0.05). Conclusions Placement of self-tapping implants with low insertion torque into sites prepared by lateral bone condensing technique might be advantageous in terms of thermal effect on bone.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical Oral Implants Research
T1  - Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design
VL  - 24
IS  - 7
SP  - 798
EP  - 805
DO  - 10.1111/j.1600-0501.2012.02460.x
ER  - 

@article{
author = "Marković, Aleksa and Mišić, Tijana and Miličić, Biljana and Calvo Guirado, Jose Luis and Aleksić, Zoran and Đinić, Ana",
year = "2013",
abstract = "Objectives The study aimed to investigate the effect of surgical technique, implant macrodesign and insertion torque on bone temperature changes during implant placement. Material and methods In the in vitro study, 144 self-tapping (blueSKY (R) 4x10mm; Bredent) and 144 non-self-tapping (Standard implant (R) 4.1x10mm; Straumann) were placed in osteotomies prepared in pig ribs by lateral bone condensing or bone drilling techniques. The maximum insertion torque values of 30, 35 and 40Ncm were used. Real-time bone temperature measurement during implant placement was performed by three thermocouples positioned vertically, in tripod configuration around every osteotomy, at a distance of 5mm from it and at depths of 1, 5 and 10mm. Data were analysed using Kruskal-Wallis, Mann-Whitney U-tests and Regression analysis. Results Significant predictor of bone temperature at the osteotomy depth of 1mm was insertion torque (P=0.003) and at the depth of 10-mm implant macrodesign (P=0.029), while no significant predictor at depth of 5mm was identified (0.05). Higher insertion torque values as well as non-self-tapping implant macrodesign were related to higher temperatures. Implant placement in sites prepared by bone drilling induced significantly higher temperature increase (P=0.021) compared with bone condensing sites at the depth of 5mm, while no significant difference was recorded at other depths. Compared with 30Ncm, insertion torque values of 35 and 40Ncm produced significantly higher temperature increase (P=0.005; P=0.003, respectively) at the depth of 1mm. There was no significant difference in temperature change induced by 35 and 40Ncm, neither by implant macrodesign at all investigated depths (0.05). Conclusions Placement of self-tapping implants with low insertion torque into sites prepared by lateral bone condensing technique might be advantageous in terms of thermal effect on bone.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design",
volume = "24",
number = "7",
pages = "798-805",
doi = "10.1111/j.1600-0501.2012.02460.x"
}

Marković, A., Mišić, T., Miličić, B., Calvo Guirado, J. L., Aleksić, Z.,& Đinić, A.. (2013). Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design. in Clinical Oral Implants Research
Wiley-Blackwell, Hoboken., 24(7), 798-805.
https://doi.org/10.1111/j.1600-0501.2012.02460.x

Marković A, Mišić T, Miličić B, Calvo Guirado JL, Aleksić Z, Đinić A. Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design. in Clinical Oral Implants Research. 2013;24(7):798-805.
doi:10.1111/j.1600-0501.2012.02460.x .

Marković, Aleksa, Mišić, Tijana, Miličić, Biljana, Calvo Guirado, Jose Luis, Aleksić, Zoran, Đinić, Ana, "Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design" in Clinical Oral Implants Research, 24, no. 7 (2013):798-805,
https://doi.org/10.1111/j.1600-0501.2012.02460.x . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Luis Calvo-Guirado, Jose
AU  - Lazić, Zoran
AU  - Gomez-Moreno, Gerardo
AU  - Ćalasan, Dejan
AU  - Guardia, Javier
AU  - Čolić, Snježana
AU  - Aguilar-Salvatierra, Antonio
AU  - Gačić, Bojan
AU  - Delgado-Ruiz, Rafael
AU  - Janjić, Bojan
AU  - Mišić, Tijana
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1816
AB  - Purpose: The aim of this study was to investigate the relationship between surgical techniques and implant macro-design (self-tapping/non-self-tapping) for the optimization of implant stability in the low-density bone present in the posterior maxilla using resonance frequency analysis (RFA). Materials and Methods: A total of 102 implants were studied. Fifty-six self-tapping BlueSkyBredent (R) (Bredent GmbH &, Senden, Germany) and 56 non-self-tapping Standard Plus Straumann (R) (Institut Straumann AG (R), Waldenburg, Switzerland) were placed in the posterior segment of the maxilla. Implants of both types were placed in sites prepared with either lateral bone-condensing or with bone-drilling techniques. Implant stability measurements were performed using RFA immediately after implant placement and weekly during a 12-week follow-up period. Results: Both types of implants placed after bone condensing achieved significantly higher stability immediately after surgery, as well as during the entire 12-week observation period compared with those placed following bone drilling. After bone condensation, there were no significant differences in primary stability or in implant stability after the first week between both implant types. From 2 to 12 postoperative weeks, significantly higher stability was shown by self-tapping implants. After bone drilling, self-tapping implants achieved significantly higher stability than non-self-tapping implants during the entire follow-up period. Conclusions: The outcomes of the present study indicate that bone drilling is not an effective technique for improving implant stability and, following this technique, the use of self-tapping implants is highly recommended. Implant stability optimization in the soft bone can be achieved by lateral bone-condensing technique, regardless of implant macro-design.
PB  - Wiley, Hoboken
T2  - Clinical Implant Dentistry & Related Research
T1  - Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study
VL  - 15
IS  - 3
SP  - 341
EP  - 349
DO  - 10.1111/j.1708-8208.2011.00415.x
ER  - 

@article{
author = "Marković, Aleksa and Luis Calvo-Guirado, Jose and Lazić, Zoran and Gomez-Moreno, Gerardo and Ćalasan, Dejan and Guardia, Javier and Čolić, Snježana and Aguilar-Salvatierra, Antonio and Gačić, Bojan and Delgado-Ruiz, Rafael and Janjić, Bojan and Mišić, Tijana",
year = "2013",
abstract = "Purpose: The aim of this study was to investigate the relationship between surgical techniques and implant macro-design (self-tapping/non-self-tapping) for the optimization of implant stability in the low-density bone present in the posterior maxilla using resonance frequency analysis (RFA). Materials and Methods: A total of 102 implants were studied. Fifty-six self-tapping BlueSkyBredent (R) (Bredent GmbH &, Senden, Germany) and 56 non-self-tapping Standard Plus Straumann (R) (Institut Straumann AG (R), Waldenburg, Switzerland) were placed in the posterior segment of the maxilla. Implants of both types were placed in sites prepared with either lateral bone-condensing or with bone-drilling techniques. Implant stability measurements were performed using RFA immediately after implant placement and weekly during a 12-week follow-up period. Results: Both types of implants placed after bone condensing achieved significantly higher stability immediately after surgery, as well as during the entire 12-week observation period compared with those placed following bone drilling. After bone condensation, there were no significant differences in primary stability or in implant stability after the first week between both implant types. From 2 to 12 postoperative weeks, significantly higher stability was shown by self-tapping implants. After bone drilling, self-tapping implants achieved significantly higher stability than non-self-tapping implants during the entire follow-up period. Conclusions: The outcomes of the present study indicate that bone drilling is not an effective technique for improving implant stability and, following this technique, the use of self-tapping implants is highly recommended. Implant stability optimization in the soft bone can be achieved by lateral bone-condensing technique, regardless of implant macro-design.",
publisher = "Wiley, Hoboken",
journal = "Clinical Implant Dentistry & Related Research",
title = "Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study",
volume = "15",
number = "3",
pages = "341-349",
doi = "10.1111/j.1708-8208.2011.00415.x"
}

Marković, A., Luis Calvo-Guirado, J., Lazić, Z., Gomez-Moreno, G., Ćalasan, D., Guardia, J., Čolić, S., Aguilar-Salvatierra, A., Gačić, B., Delgado-Ruiz, R., Janjić, B.,& Mišić, T.. (2013). Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study. in Clinical Implant Dentistry & Related Research
Wiley, Hoboken., 15(3), 341-349.
https://doi.org/10.1111/j.1708-8208.2011.00415.x

Marković A, Luis Calvo-Guirado J, Lazić Z, Gomez-Moreno G, Ćalasan D, Guardia J, Čolić S, Aguilar-Salvatierra A, Gačić B, Delgado-Ruiz R, Janjić B, Mišić T. Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study. in Clinical Implant Dentistry & Related Research. 2013;15(3):341-349.
doi:10.1111/j.1708-8208.2011.00415.x .

Marković, Aleksa, Luis Calvo-Guirado, Jose, Lazić, Zoran, Gomez-Moreno, Gerardo, Ćalasan, Dejan, Guardia, Javier, Čolić, Snježana, Aguilar-Salvatierra, Antonio, Gačić, Bojan, Delgado-Ruiz, Rafael, Janjić, Bojan, Mišić, Tijana, "Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study" in Clinical Implant Dentistry & Related Research, 15, no. 3 (2013):341-349,
https://doi.org/10.1111/j.1708-8208.2011.00415.x . .

TY  - JOUR
AU  - Šćepanović, Miodrag
AU  - Luis Calvo-Guirado, Jose
AU  - Marković, Aleksa
AU  - Delgado-Ruiz, Rafael
AU  - Todorović, Aleksandar
AU  - Miličić, Biljana
AU  - Mišić, Tijana
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1687
AB  - Aim: The aim of this 1-year prospective cohort study was to evaluate the outcomes and complications of immediately loaded mini dental implants used for stabilizing mandibular overdentures in edentulous patients wearing conventional complete dentures. Materials and methods: Thirty patients received mandibular conventional complete dentures that were subsequently retained by 4 immediately loaded mini dental implants placed in the interforaminal region. Overdenture success, implant success and biological and prosthetic complications were evaluated after the first year of service. Quality of life using the Oral Heath Impact Profile (OHIP)-EDENT test, satisfaction with dental prosthesis and chewing efficiency using questionnaires and a Visual Analogue Scale (VAS) were evaluated twice: after they had received mandibular complete dentures, and again after they had received mandibular overdentures. Results: After 1 year, no overdenture failed and 2 implants did not osseointegrate, resulting in a 98.3% success rate for loaded implants and 95.9% for total implants used (3 out of 123 were not loaded due to fracture). A flap surgical approach was performed in 7 patients, 3 implants fractured during insertion, 3 overdentures fractured, occlusion balancing was necessary for 11 dentures and relining for 8. Implant rehabilitation provided significant improvement in quality of life, stability, comfort, chewing and speaking ability while no significant differences were found in quality of maintenance of hygiene and for aesthetics. Conclusions: Mini dental implant retained overdentures can be a successful therapeutic procedure for treating mandibular edentulism that improves quality of life, patient satisfaction and chewing ability in patients wearing maxillary dentures. Longer follow-ups are needed to validate this therapy in the medium and long-term.
PB  - Quintessence Publishing Co., Ltd
T2  - European Journal of Oral Implantology
T1  - A 1-year prospective cohort study on mandibular overdentures retained by mini dental implants
VL  - 5
IS  - 4
SP  - 367
EP  - 379
UR  - https://hdl.handle.net/21.15107/rcub_smile_1687
ER  - 

@article{
author = "Šćepanović, Miodrag and Luis Calvo-Guirado, Jose and Marković, Aleksa and Delgado-Ruiz, Rafael and Todorović, Aleksandar and Miličić, Biljana and Mišić, Tijana",
year = "2012",
abstract = "Aim: The aim of this 1-year prospective cohort study was to evaluate the outcomes and complications of immediately loaded mini dental implants used for stabilizing mandibular overdentures in edentulous patients wearing conventional complete dentures. Materials and methods: Thirty patients received mandibular conventional complete dentures that were subsequently retained by 4 immediately loaded mini dental implants placed in the interforaminal region. Overdenture success, implant success and biological and prosthetic complications were evaluated after the first year of service. Quality of life using the Oral Heath Impact Profile (OHIP)-EDENT test, satisfaction with dental prosthesis and chewing efficiency using questionnaires and a Visual Analogue Scale (VAS) were evaluated twice: after they had received mandibular complete dentures, and again after they had received mandibular overdentures. Results: After 1 year, no overdenture failed and 2 implants did not osseointegrate, resulting in a 98.3% success rate for loaded implants and 95.9% for total implants used (3 out of 123 were not loaded due to fracture). A flap surgical approach was performed in 7 patients, 3 implants fractured during insertion, 3 overdentures fractured, occlusion balancing was necessary for 11 dentures and relining for 8. Implant rehabilitation provided significant improvement in quality of life, stability, comfort, chewing and speaking ability while no significant differences were found in quality of maintenance of hygiene and for aesthetics. Conclusions: Mini dental implant retained overdentures can be a successful therapeutic procedure for treating mandibular edentulism that improves quality of life, patient satisfaction and chewing ability in patients wearing maxillary dentures. Longer follow-ups are needed to validate this therapy in the medium and long-term.",
publisher = "Quintessence Publishing Co., Ltd",
journal = "European Journal of Oral Implantology",
title = "A 1-year prospective cohort study on mandibular overdentures retained by mini dental implants",
volume = "5",
number = "4",
pages = "367-379",
url = "https://hdl.handle.net/21.15107/rcub_smile_1687"
}

Šćepanović, M., Luis Calvo-Guirado, J., Marković, A., Delgado-Ruiz, R., Todorović, A., Miličić, B.,& Mišić, T.. (2012). A 1-year prospective cohort study on mandibular overdentures retained by mini dental implants. in European Journal of Oral Implantology
Quintessence Publishing Co., Ltd., 5(4), 367-379.
https://hdl.handle.net/21.15107/rcub_smile_1687

Šćepanović M, Luis Calvo-Guirado J, Marković A, Delgado-Ruiz R, Todorović A, Miličić B, Mišić T. A 1-year prospective cohort study on mandibular overdentures retained by mini dental implants. in European Journal of Oral Implantology. 2012;5(4):367-379.
https://hdl.handle.net/21.15107/rcub_smile_1687 .

Šćepanović, Miodrag, Luis Calvo-Guirado, Jose, Marković, Aleksa, Delgado-Ruiz, Rafael, Todorović, Aleksandar, Miličić, Biljana, Mišić, Tijana, "A 1-year prospective cohort study on mandibular overdentures retained by mini dental implants" in European Journal of Oral Implantology, 5, no. 4 (2012):367-379,
https://hdl.handle.net/21.15107/rcub_smile_1687 .