Stanimirović, Dragan

Link to this page

Authority KeyName Variants
4204ad1d-1e6f-4fab-a86a-3a6a0d1b1d4b
  • Stanimirović, Dragan (15)
Projects

Author's Bibliography

Recasting as a booster of Ag-Pd alloy cytotoxicity: induction of cell senescence prior to mass cell death

Čairović, Aleksandra; Stanimirović, Dragan; Krajnović, Tamara T.; Dojčinović, Biljana; Maksimović, Vesna; Cvijović-Alagić, Ivana

(Srpsko biološko društvo, Beograd, i dr., 2019)

TY  - JOUR
AU  - Čairović, Aleksandra
AU  - Stanimirović, Dragan
AU  - Krajnović, Tamara T.
AU  - Dojčinović, Biljana
AU  - Maksimović, Vesna
AU  - Cvijović-Alagić, Ivana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2386
AB  - The biological quality and chemical composition of alloys used in dental practice change during heat treatment. Often the residues of the previous cast are not disposed of but are reused and recycled until consumed. Thus, manufactured dental restorations have modified biological quality and chemical composition, and compromised biocompatibility. The aim of this study was to investigate the influence of repeated casting on the cytotoxicity of the silver-palladium (Ag-Pd) alloy. Our results showed that repeated casting of the Ag-Pd dental alloy affected its biocompatibility by promoting toxicity against transformed fibroblasts in a contact-independent manner. A strong decrease in cell proliferation, induction of senescence and massive cell death were observed in cultures exposed only to a medium previously incubated with dental alloy samples. The obtained data indicated that toxicity mediated by the accumulation of the Ag, Pd, Cu and Zn cations released from the Ag-Pd material was enhanced by recasting. The induction of cell senescence and subsequent apoptotic and necrotic death were accompanied by amplified intracellular production of reactive oxygen and nitrogen species, suggesting their involvement in the cell destruction process. Therefore, compromised biocompatibility after recasting with the Ag-Pd alloy can be the cause of serious local cell destruction, as observed in clinical practice.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Recasting as a booster of Ag-Pd alloy cytotoxicity: induction of cell senescence prior to mass cell death
VL  - 71
IS  - 2
SP  - 347
EP  - 356
DO  - 10.2298/ABS190305017C
ER  - 
@article{
author = "Čairović, Aleksandra and Stanimirović, Dragan and Krajnović, Tamara T. and Dojčinović, Biljana and Maksimović, Vesna and Cvijović-Alagić, Ivana",
year = "2019",
abstract = "The biological quality and chemical composition of alloys used in dental practice change during heat treatment. Often the residues of the previous cast are not disposed of but are reused and recycled until consumed. Thus, manufactured dental restorations have modified biological quality and chemical composition, and compromised biocompatibility. The aim of this study was to investigate the influence of repeated casting on the cytotoxicity of the silver-palladium (Ag-Pd) alloy. Our results showed that repeated casting of the Ag-Pd dental alloy affected its biocompatibility by promoting toxicity against transformed fibroblasts in a contact-independent manner. A strong decrease in cell proliferation, induction of senescence and massive cell death were observed in cultures exposed only to a medium previously incubated with dental alloy samples. The obtained data indicated that toxicity mediated by the accumulation of the Ag, Pd, Cu and Zn cations released from the Ag-Pd material was enhanced by recasting. The induction of cell senescence and subsequent apoptotic and necrotic death were accompanied by amplified intracellular production of reactive oxygen and nitrogen species, suggesting their involvement in the cell destruction process. Therefore, compromised biocompatibility after recasting with the Ag-Pd alloy can be the cause of serious local cell destruction, as observed in clinical practice.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Recasting as a booster of Ag-Pd alloy cytotoxicity: induction of cell senescence prior to mass cell death",
volume = "71",
number = "2",
pages = "347-356",
doi = "10.2298/ABS190305017C"
}
Čairović, A., Stanimirović, D., Krajnović, T. T., Dojčinović, B., Maksimović, V.,& Cvijović-Alagić, I.. (2019). Recasting as a booster of Ag-Pd alloy cytotoxicity: induction of cell senescence prior to mass cell death. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 71(2), 347-356.
https://doi.org/10.2298/ABS190305017C
Čairović A, Stanimirović D, Krajnović TT, Dojčinović B, Maksimović V, Cvijović-Alagić I. Recasting as a booster of Ag-Pd alloy cytotoxicity: induction of cell senescence prior to mass cell death. in Archives of Biological Sciences. 2019;71(2):347-356.
doi:10.2298/ABS190305017C .
Čairović, Aleksandra, Stanimirović, Dragan, Krajnović, Tamara T., Dojčinović, Biljana, Maksimović, Vesna, Cvijović-Alagić, Ivana, "Recasting as a booster of Ag-Pd alloy cytotoxicity: induction of cell senescence prior to mass cell death" in Archives of Biological Sciences, 71, no. 2 (2019):347-356,
https://doi.org/10.2298/ABS190305017C . .

The efficacy of fluoxetine in BMS-A cross-over study

Zorić, Bojana; Janković, Ljiljana; Kuzmanović-Pfićer, Jovana; Zidverc-Trajković, Jasna; Mijajlović, Milija; Stanimirović, Dragan

(Wiley, Hoboken, 2018)

TY  - JOUR
AU  - Zorić, Bojana
AU  - Janković, Ljiljana
AU  - Kuzmanović-Pfićer, Jovana
AU  - Zidverc-Trajković, Jasna
AU  - Mijajlović, Milija
AU  - Stanimirović, Dragan
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2288
AB  - Background: Burning mouth syndrome (BMS) is an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than 3 months. The objective was to evaluate and analyse the efficacy of serotonin reuptake inhibitor fluoxetine on psychological factors, as well as on pain in participants with BMS. Methods: In a 6-month study, 100 participants with primary and secondary BMS were divided into two groups-fluoxetine and control (placebo) and examined by the dentist and the neurologist. Depression and anxiety were estimated by Hamilton Scale for Depression (HAM-D) and Anxiety (HAM-A) and Beck Depression Inventory (BDI) and the pain intensity by visual analogue scale (VAS). Results: Mean age of the participants was 60.33 in fluoxetine group and 67.4 in control group. Most of the participants were female-74% in the fluoxetine and 78% in the control group. Statistical difference between the fluoxetine and the control group was found in HAM-D results (P  lt  .05). Values of other scales and VAS decreased significantly after the therapy in both groups (P  lt  .05). Conclusions: Our trial results indicate that fluoxetine therapy not only improves the psychological status of participants with BMS but also fluoxetine decreases the intensity of pain in these patients.
PB  - Wiley, Hoboken
T2  - Gerodontology
T1  - The efficacy of fluoxetine in BMS-A cross-over study
VL  - 35
IS  - 2
SP  - 123
EP  - 128
DO  - 10.1111/ger.12332
ER  - 
@article{
author = "Zorić, Bojana and Janković, Ljiljana and Kuzmanović-Pfićer, Jovana and Zidverc-Trajković, Jasna and Mijajlović, Milija and Stanimirović, Dragan",
year = "2018",
abstract = "Background: Burning mouth syndrome (BMS) is an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than 3 months. The objective was to evaluate and analyse the efficacy of serotonin reuptake inhibitor fluoxetine on psychological factors, as well as on pain in participants with BMS. Methods: In a 6-month study, 100 participants with primary and secondary BMS were divided into two groups-fluoxetine and control (placebo) and examined by the dentist and the neurologist. Depression and anxiety were estimated by Hamilton Scale for Depression (HAM-D) and Anxiety (HAM-A) and Beck Depression Inventory (BDI) and the pain intensity by visual analogue scale (VAS). Results: Mean age of the participants was 60.33 in fluoxetine group and 67.4 in control group. Most of the participants were female-74% in the fluoxetine and 78% in the control group. Statistical difference between the fluoxetine and the control group was found in HAM-D results (P  lt  .05). Values of other scales and VAS decreased significantly after the therapy in both groups (P  lt  .05). Conclusions: Our trial results indicate that fluoxetine therapy not only improves the psychological status of participants with BMS but also fluoxetine decreases the intensity of pain in these patients.",
publisher = "Wiley, Hoboken",
journal = "Gerodontology",
title = "The efficacy of fluoxetine in BMS-A cross-over study",
volume = "35",
number = "2",
pages = "123-128",
doi = "10.1111/ger.12332"
}
Zorić, B., Janković, L., Kuzmanović-Pfićer, J., Zidverc-Trajković, J., Mijajlović, M.,& Stanimirović, D.. (2018). The efficacy of fluoxetine in BMS-A cross-over study. in Gerodontology
Wiley, Hoboken., 35(2), 123-128.
https://doi.org/10.1111/ger.12332
Zorić B, Janković L, Kuzmanović-Pfićer J, Zidverc-Trajković J, Mijajlović M, Stanimirović D. The efficacy of fluoxetine in BMS-A cross-over study. in Gerodontology. 2018;35(2):123-128.
doi:10.1111/ger.12332 .
Zorić, Bojana, Janković, Ljiljana, Kuzmanović-Pfićer, Jovana, Zidverc-Trajković, Jasna, Mijajlović, Milija, Stanimirović, Dragan, "The efficacy of fluoxetine in BMS-A cross-over study" in Gerodontology, 35, no. 2 (2018):123-128,
https://doi.org/10.1111/ger.12332 . .
8
8
12

Expression and role of p53 in oral lichen planus patients

Hadži-Mihailović, Miloš; Petrović, Renata; Raybaud, Helene; Stanimirović, Dragan; Koray, Meltem Ozar

(Balkan Union of Oncology (B.U.ON.), 2017)

TY  - JOUR
AU  - Hadži-Mihailović, Miloš
AU  - Petrović, Renata
AU  - Raybaud, Helene
AU  - Stanimirović, Dragan
AU  - Koray, Meltem Ozar
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2208
AB  - Purpose: Oral lichen planus (OLP) is an autoimmune skin and mucosal disorder. The range of malignant transformation in OLP varies between 0.1-3%. p53 is a tumor suppressor protein. Defective p53 could allow abnormal cells to proliferate, resulting in cancer. p53 plays an important role in cell cycle control and apoptosis and loss of p53 function has been demonstrated in about half of all human cancers. The purpose of the study was to investigate the malignant potential of OLP on the basis of p53 expression and to correlate p53 expression with clinical and histopathological features of OLP. Methods: 40 patients with OLP underwent biopsy. All tissue samples were treated immunohistochemicaly using avidin-biotin peroxidase complex method. Results: In 80% of OLP specimens the nuclei of basal and parabasal keratinocytes were p53-positive, but in low numbers. Low percentage of p53-positive cells in older and medium percentage of p53-positive cells in younger group of OLP patients were noted. Higher intensity of p53 stained keratinocytes, no matter their low number, could represent mutant and more stable form of p53 protein, and at the same time signal for monitoring of disease due to potential malignant transformation. Low percentage and weak intensity of p53-positive cells was detected mostly in OLP specimens with highly expressed civatte bodies (CB). Upregulation of apoptosis didn't correspond with the expression of CB. Conclusion: We believe that low percentage of p53-positive and well-marked keratinocytes in OLP represent the influence of mutant p53 protein, and that increasing expression of this protein could serve as a valuable diagnostic sign of early carcinogenesis. According to our results intensity of p53 coloration of keratinocytes could help assessing the malignant potential of OLP.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Expression and role of p53 in oral lichen planus patients
VL  - 22
IS  - 5
SP  - 1278
EP  - 1286
UR  - https://hdl.handle.net/21.15107/rcub_smile_2208
ER  - 
@article{
author = "Hadži-Mihailović, Miloš and Petrović, Renata and Raybaud, Helene and Stanimirović, Dragan and Koray, Meltem Ozar",
year = "2017",
abstract = "Purpose: Oral lichen planus (OLP) is an autoimmune skin and mucosal disorder. The range of malignant transformation in OLP varies between 0.1-3%. p53 is a tumor suppressor protein. Defective p53 could allow abnormal cells to proliferate, resulting in cancer. p53 plays an important role in cell cycle control and apoptosis and loss of p53 function has been demonstrated in about half of all human cancers. The purpose of the study was to investigate the malignant potential of OLP on the basis of p53 expression and to correlate p53 expression with clinical and histopathological features of OLP. Methods: 40 patients with OLP underwent biopsy. All tissue samples were treated immunohistochemicaly using avidin-biotin peroxidase complex method. Results: In 80% of OLP specimens the nuclei of basal and parabasal keratinocytes were p53-positive, but in low numbers. Low percentage of p53-positive cells in older and medium percentage of p53-positive cells in younger group of OLP patients were noted. Higher intensity of p53 stained keratinocytes, no matter their low number, could represent mutant and more stable form of p53 protein, and at the same time signal for monitoring of disease due to potential malignant transformation. Low percentage and weak intensity of p53-positive cells was detected mostly in OLP specimens with highly expressed civatte bodies (CB). Upregulation of apoptosis didn't correspond with the expression of CB. Conclusion: We believe that low percentage of p53-positive and well-marked keratinocytes in OLP represent the influence of mutant p53 protein, and that increasing expression of this protein could serve as a valuable diagnostic sign of early carcinogenesis. According to our results intensity of p53 coloration of keratinocytes could help assessing the malignant potential of OLP.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Expression and role of p53 in oral lichen planus patients",
volume = "22",
number = "5",
pages = "1278-1286",
url = "https://hdl.handle.net/21.15107/rcub_smile_2208"
}
Hadži-Mihailović, M., Petrović, R., Raybaud, H., Stanimirović, D.,& Koray, M. O.. (2017). Expression and role of p53 in oral lichen planus patients. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 22(5), 1278-1286.
https://hdl.handle.net/21.15107/rcub_smile_2208
Hadži-Mihailović M, Petrović R, Raybaud H, Stanimirović D, Koray MO. Expression and role of p53 in oral lichen planus patients. in Journal of BUON. 2017;22(5):1278-1286.
https://hdl.handle.net/21.15107/rcub_smile_2208 .
Hadži-Mihailović, Miloš, Petrović, Renata, Raybaud, Helene, Stanimirović, Dragan, Koray, Meltem Ozar, "Expression and role of p53 in oral lichen planus patients" in Journal of BUON, 22, no. 5 (2017):1278-1286,
https://hdl.handle.net/21.15107/rcub_smile_2208 .
6

Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk

Kujundzić, Bojan; Zeljić, Katarina; Supić, Gordana; Magić, Marko; Stanimirović, Dragan; Ilić, Vesna; Jovanović, Barbara; Magić, Zvonko

(Springer Heidelberg, Heidelberg, 2016)

TY  - JOUR
AU  - Kujundzić, Bojan
AU  - Zeljić, Katarina
AU  - Supić, Gordana
AU  - Magić, Marko
AU  - Stanimirović, Dragan
AU  - Ilić, Vesna
AU  - Jovanović, Barbara
AU  - Magić, Zvonko
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2136
AB  - The current study investigated the association between VDR EcoRV (rs4516035), FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236), CYP27B1 (rs4646536), CYP24A1 (rs2296241), and MTHFR (rs1801133) gene polymorphisms and risk of oral lichen planus (OLP) occurrence. The study group consisted of 65 oral lichen planus patients and 100 healthy blood donors in the control group. Single nucleotide polymorphisms were genotyped by real time PCR or PCR-restriction fragment length polymorphism (RFLP) method. Heterozygous as well as mutated genotype of vitamin D receptor (VDR) FokI (rs2228570) polymorphism was associated with increased oral lichen planus risk in comparison with wild type genotype (odds ratio (OR) = 3.877, p = 0.017, OR = 38.153, p = 0.001, respectively). A significantly decreased OLP risk was observed for heterozygous genotype of rs2296241 polymorphism in CYP24A1 gene compared with the wild type form (OR = 0.314, p = 0.012). VDR gene polymorphisms ApaI and TaqI were in linkage disequilibrium (D' = 0.71, r (2) = 0.22). Identified haplotype AT was associated with decreased OLP risk (OR = 0.592, p = 0.047). Our results highlight the possible important role of VDR FokI (rs2228570) and CYP24A1 rs2296241 gene polymorphisms for oral lichen planus susceptibility. Identification of new molecular biomarkers could potentially contribute to determination of individuals with OLP predisposition.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk
VL  - 20
IS  - 4
SP  - 781
EP  - 789
DO  - 10.1007/s00784-015-1572-7
ER  - 
@article{
author = "Kujundzić, Bojan and Zeljić, Katarina and Supić, Gordana and Magić, Marko and Stanimirović, Dragan and Ilić, Vesna and Jovanović, Barbara and Magić, Zvonko",
year = "2016",
abstract = "The current study investigated the association between VDR EcoRV (rs4516035), FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236), CYP27B1 (rs4646536), CYP24A1 (rs2296241), and MTHFR (rs1801133) gene polymorphisms and risk of oral lichen planus (OLP) occurrence. The study group consisted of 65 oral lichen planus patients and 100 healthy blood donors in the control group. Single nucleotide polymorphisms were genotyped by real time PCR or PCR-restriction fragment length polymorphism (RFLP) method. Heterozygous as well as mutated genotype of vitamin D receptor (VDR) FokI (rs2228570) polymorphism was associated with increased oral lichen planus risk in comparison with wild type genotype (odds ratio (OR) = 3.877, p = 0.017, OR = 38.153, p = 0.001, respectively). A significantly decreased OLP risk was observed for heterozygous genotype of rs2296241 polymorphism in CYP24A1 gene compared with the wild type form (OR = 0.314, p = 0.012). VDR gene polymorphisms ApaI and TaqI were in linkage disequilibrium (D' = 0.71, r (2) = 0.22). Identified haplotype AT was associated with decreased OLP risk (OR = 0.592, p = 0.047). Our results highlight the possible important role of VDR FokI (rs2228570) and CYP24A1 rs2296241 gene polymorphisms for oral lichen planus susceptibility. Identification of new molecular biomarkers could potentially contribute to determination of individuals with OLP predisposition.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk",
volume = "20",
number = "4",
pages = "781-789",
doi = "10.1007/s00784-015-1572-7"
}
Kujundzić, B., Zeljić, K., Supić, G., Magić, M., Stanimirović, D., Ilić, V., Jovanović, B.,& Magić, Z.. (2016). Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 20(4), 781-789.
https://doi.org/10.1007/s00784-015-1572-7
Kujundzić B, Zeljić K, Supić G, Magić M, Stanimirović D, Ilić V, Jovanović B, Magić Z. Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk. in Clinical Oral Investigations. 2016;20(4):781-789.
doi:10.1007/s00784-015-1572-7 .
Kujundzić, Bojan, Zeljić, Katarina, Supić, Gordana, Magić, Marko, Stanimirović, Dragan, Ilić, Vesna, Jovanović, Barbara, Magić, Zvonko, "Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk" in Clinical Oral Investigations, 20, no. 4 (2016):781-789,
https://doi.org/10.1007/s00784-015-1572-7 . .
19
15
16

Association of polymorphisms of TLR2, TLR3, TLR4 and CD14 gene with the risk of oral lichen planus

Hadži-Mihailović, Miloš; Stanimirović, Dragan; Đorđević, M.; Bjelić, B.

(Wiley, Hoboken, 2016)

TY  - CONF
AU  - Hadži-Mihailović, Miloš
AU  - Stanimirović, Dragan
AU  - Đorđević, M.
AU  - Bjelić, B.
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2151
PB  - Wiley, Hoboken
C3  - Oral Diseases
T1  - Association of polymorphisms of TLR2, TLR3, TLR4 and CD14 gene with the risk of oral lichen planus
VL  - 22
SP  - 34
EP  - 34
UR  - https://hdl.handle.net/21.15107/rcub_smile_2151
ER  - 
@conference{
author = "Hadži-Mihailović, Miloš and Stanimirović, Dragan and Đorđević, M. and Bjelić, B.",
year = "2016",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "Association of polymorphisms of TLR2, TLR3, TLR4 and CD14 gene with the risk of oral lichen planus",
volume = "22",
pages = "34-34",
url = "https://hdl.handle.net/21.15107/rcub_smile_2151"
}
Hadži-Mihailović, M., Stanimirović, D., Đorđević, M.,& Bjelić, B.. (2016). Association of polymorphisms of TLR2, TLR3, TLR4 and CD14 gene with the risk of oral lichen planus. in Oral Diseases
Wiley, Hoboken., 22, 34-34.
https://hdl.handle.net/21.15107/rcub_smile_2151
Hadži-Mihailović M, Stanimirović D, Đorđević M, Bjelić B. Association of polymorphisms of TLR2, TLR3, TLR4 and CD14 gene with the risk of oral lichen planus. in Oral Diseases. 2016;22:34-34.
https://hdl.handle.net/21.15107/rcub_smile_2151 .
Hadži-Mihailović, Miloš, Stanimirović, Dragan, Đorđević, M., Bjelić, B., "Association of polymorphisms of TLR2, TLR3, TLR4 and CD14 gene with the risk of oral lichen planus" in Oral Diseases, 22 (2016):34-34,
https://hdl.handle.net/21.15107/rcub_smile_2151 .

HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients

Supić, Gordana; Kozomara, Ružica; Zeljić, Katarina; Stanimirović, Dragan; Magić, Marko; Surbatović, M.; Jović, N.; Magić, Zvonko

(Wiley, Hoboken, 2015)

TY  - JOUR
AU  - Supić, Gordana
AU  - Kozomara, Ružica
AU  - Zeljić, Katarina
AU  - Stanimirović, Dragan
AU  - Magić, Marko
AU  - Surbatović, M.
AU  - Jović, N.
AU  - Magić, Zvonko
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1976
AB  - ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients
VL  - 21
IS  - 4
SP  - 536
EP  - 543
DO  - 10.1111/odi.12318
ER  - 
@article{
author = "Supić, Gordana and Kozomara, Ružica and Zeljić, Katarina and Stanimirović, Dragan and Magić, Marko and Surbatović, M. and Jović, N. and Magić, Zvonko",
year = "2015",
abstract = "ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients",
volume = "21",
number = "4",
pages = "536-543",
doi = "10.1111/odi.12318"
}
Supić, G., Kozomara, R., Zeljić, K., Stanimirović, D., Magić, M., Surbatović, M., Jović, N.,& Magić, Z.. (2015). HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases
Wiley, Hoboken., 21(4), 536-543.
https://doi.org/10.1111/odi.12318
Supić G, Kozomara R, Zeljić K, Stanimirović D, Magić M, Surbatović M, Jović N, Magić Z. HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases. 2015;21(4):536-543.
doi:10.1111/odi.12318 .
Supić, Gordana, Kozomara, Ružica, Zeljić, Katarina, Stanimirović, Dragan, Magić, Marko, Surbatović, M., Jović, N., Magić, Zvonko, "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients" in Oral Diseases, 21, no. 4 (2015):536-543,
https://doi.org/10.1111/odi.12318 . .
22
17
20

Expression and role of p53 in OLP patients

Hadži-Mihailović, Miloš; Stanimirović, Dragan; Petrović, Renata

(Wiley-Blackwell, Hoboken, 2014)

TY  - CONF
AU  - Hadži-Mihailović, Miloš
AU  - Stanimirović, Dragan
AU  - Petrović, Renata
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1929
PB  - Wiley-Blackwell, Hoboken
C3  - Oral Diseases
T1  - Expression and role of p53 in OLP patients
VL  - 20
SP  - 14
EP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_smile_1929
ER  - 
@conference{
author = "Hadži-Mihailović, Miloš and Stanimirović, Dragan and Petrović, Renata",
year = "2014",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Oral Diseases",
title = "Expression and role of p53 in OLP patients",
volume = "20",
pages = "14-14",
url = "https://hdl.handle.net/21.15107/rcub_smile_1929"
}
Hadži-Mihailović, M., Stanimirović, D.,& Petrović, R.. (2014). Expression and role of p53 in OLP patients. in Oral Diseases
Wiley-Blackwell, Hoboken., 20, 14-14.
https://hdl.handle.net/21.15107/rcub_smile_1929
Hadži-Mihailović M, Stanimirović D, Petrović R. Expression and role of p53 in OLP patients. in Oral Diseases. 2014;20:14-14.
https://hdl.handle.net/21.15107/rcub_smile_1929 .
Hadži-Mihailović, Miloš, Stanimirović, Dragan, Petrović, Renata, "Expression and role of p53 in OLP patients" in Oral Diseases, 20 (2014):14-14,
https://hdl.handle.net/21.15107/rcub_smile_1929 .

Histopathological features in different clinical types of OLP

Stanimirović, Dragan; Knežević, Y.; Jelić, B.; Đorđević, M.; Hadži-Mihailović, Miloš

(Wiley-Blackwell, Hoboken, 2014)

TY  - CONF
AU  - Stanimirović, Dragan
AU  - Knežević, Y.
AU  - Jelić, B.
AU  - Đorđević, M.
AU  - Hadži-Mihailović, Miloš
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1944
PB  - Wiley-Blackwell, Hoboken
C3  - Oral Diseases
T1  - Histopathological features in different clinical types of OLP
VL  - 20
SP  - 13
EP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_smile_1944
ER  - 
@conference{
author = "Stanimirović, Dragan and Knežević, Y. and Jelić, B. and Đorđević, M. and Hadži-Mihailović, Miloš",
year = "2014",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Oral Diseases",
title = "Histopathological features in different clinical types of OLP",
volume = "20",
pages = "13-14",
url = "https://hdl.handle.net/21.15107/rcub_smile_1944"
}
Stanimirović, D., Knežević, Y., Jelić, B., Đorđević, M.,& Hadži-Mihailović, M.. (2014). Histopathological features in different clinical types of OLP. in Oral Diseases
Wiley-Blackwell, Hoboken., 20, 13-14.
https://hdl.handle.net/21.15107/rcub_smile_1944
Stanimirović D, Knežević Y, Jelić B, Đorđević M, Hadži-Mihailović M. Histopathological features in different clinical types of OLP. in Oral Diseases. 2014;20:13-14.
https://hdl.handle.net/21.15107/rcub_smile_1944 .
Stanimirović, Dragan, Knežević, Y., Jelić, B., Đorđević, M., Hadži-Mihailović, Miloš, "Histopathological features in different clinical types of OLP" in Oral Diseases, 20 (2014):13-14,
https://hdl.handle.net/21.15107/rcub_smile_1944 .

Nigrostriatal dopaminergic system is involved in the pathogenesis of primary burning mouth syndrome: Transcranial sonography study

Mijajlović, M.; Zidverc-Trajković, Jasna; Stanimirović, Dragan; Janković, Ljiljana; Šternić, Nadežda

(Karger, Basel, 2014)

TY  - CONF
AU  - Mijajlović, M.
AU  - Zidverc-Trajković, Jasna
AU  - Stanimirović, Dragan
AU  - Janković, Ljiljana
AU  - Šternić, Nadežda
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1862
PB  - Karger, Basel
C3  - Cerebrovascular Diseases
T1  - Nigrostriatal dopaminergic system is involved in the pathogenesis of primary burning mouth syndrome: Transcranial sonography study
VL  - 37
SP  - 48
EP  - 49
UR  - https://hdl.handle.net/21.15107/rcub_smile_1862
ER  - 
@conference{
author = "Mijajlović, M. and Zidverc-Trajković, Jasna and Stanimirović, Dragan and Janković, Ljiljana and Šternić, Nadežda",
year = "2014",
publisher = "Karger, Basel",
journal = "Cerebrovascular Diseases",
title = "Nigrostriatal dopaminergic system is involved in the pathogenesis of primary burning mouth syndrome: Transcranial sonography study",
volume = "37",
pages = "48-49",
url = "https://hdl.handle.net/21.15107/rcub_smile_1862"
}
Mijajlović, M., Zidverc-Trajković, J., Stanimirović, D., Janković, L.,& Šternić, N.. (2014). Nigrostriatal dopaminergic system is involved in the pathogenesis of primary burning mouth syndrome: Transcranial sonography study. in Cerebrovascular Diseases
Karger, Basel., 37, 48-49.
https://hdl.handle.net/21.15107/rcub_smile_1862
Mijajlović M, Zidverc-Trajković J, Stanimirović D, Janković L, Šternić N. Nigrostriatal dopaminergic system is involved in the pathogenesis of primary burning mouth syndrome: Transcranial sonography study. in Cerebrovascular Diseases. 2014;37:48-49.
https://hdl.handle.net/21.15107/rcub_smile_1862 .
Mijajlović, M., Zidverc-Trajković, Jasna, Stanimirović, Dragan, Janković, Ljiljana, Šternić, Nadežda, "Nigrostriatal dopaminergic system is involved in the pathogenesis of primary burning mouth syndrome: Transcranial sonography study" in Cerebrovascular Diseases, 37 (2014):48-49,
https://hdl.handle.net/21.15107/rcub_smile_1862 .

Udruženost poliformizma gena TLRs 2,3,4 i CD14 kod bolesnika sa oralnim lihen planusom (OLP)

Stanimirović, Dragan

(Univerzitet u Beogradu, Stomatološki fakultet, 2014)

TY  - THES
AU  - Stanimirović, Dragan
PY  - 2014
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=2672
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:10777/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=47556623
UR  - http://nardus.mpn.gov.rs/123456789/5020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/977
AB  - Uvod. Oral lihen planus (OLP) predstavlja hroničnu inflamatornu bolest oralne mukoze sa nepotpuno rasvetljenom etiologijom. Bolest pogađa oko 2-4% svetske populacije i češće se javlja kod žena. Faktori koji su asocirani sa nastankom OLP-a su: stres, dentalni materijali, dijabetes, autoimunske bolesti, prisustvo Candida albicans, Helicobacter pylori, Hepatitis C virus itd. Prethodne studije sprovedene unutar porodice su ukazale na postojanje genetičke predispozicije za razvoj OLP-a. Dodatno, OLP se često smatra i premalignom oralnom lezijom, iako je asocijacija sa nastankom oralnog karcinoma kontroverzna prema literaturnim podacima. Receptori slični Toll-u (Engl. Toll-Like Receptors - TLRs) predstavljaju veliku klasu receptora koji su uključeni u urođeni i adaptivni imuni odgovor. TLRs vezuju brojne egzogene i endogene antigene prepoznavanjem konzervisanih molekularnih obrazaca patogena (Engl. Pathogen Associated Molecular Patterns - PAMPs. Nakon aktivacije TLR, pokreću se nishodni molekulli u signalnom putu, što dovodi do ekspresije pro-inflamatornih gena. Prethodne studije su ukazale na značajnu ulogu koju TLR receptori imaju u patogenezi infekcije, inflamacije, oštećenja tkiva i nastanka kancera. U TLR genima je identifikovan veliki broj polimorfizama nukleotidne sekvence (Engl. Single Nucleotide Polymorphism – SNP). Moglo bi se pretpostaviti da polimorfizmi mogu uticati na funkcionalnost TLR receptora i povišavati/snižavati rizik za nastanak hronične infekcije. Kako je oralna mukoza direktno izložena mikroorganizmima koji mogu biti prepoznati od strane TLRova, prisustvo SNP-ova u TLR genima bi moglo imati važnu ulogu u patogenezi oralnog lihen planusa. Cilj. Cilj ove doktorske disertacije je bilo utvrđivanje postojanja asocijacije između polimorfizama TLR2 (rs3804099), TLR3 (rs3775291, rs5743312), TLR4 (rs4986791, rs4986790) i CD14 (rs2569190) gena sa rizikom za razvoj i kliničkim formama oralnog lihen planusa, kao i etiološkim faktorima. Dodatno, cilj je bila i identifikacija haplotipskih blokova u studijskoj grupi i asocijacije između registrovanih haplotipova sa rizikom za nastanak oralnog lihen planusa...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Udruženost poliformizma gena TLRs 2,3,4 i CD14 kod bolesnika sa oralnim lihen planusom (OLP)
UR  - https://hdl.handle.net/21.15107/rcub_nardus_5020
ER  - 
@phdthesis{
author = "Stanimirović, Dragan",
year = "2014",
abstract = "Uvod. Oral lihen planus (OLP) predstavlja hroničnu inflamatornu bolest oralne mukoze sa nepotpuno rasvetljenom etiologijom. Bolest pogađa oko 2-4% svetske populacije i češće se javlja kod žena. Faktori koji su asocirani sa nastankom OLP-a su: stres, dentalni materijali, dijabetes, autoimunske bolesti, prisustvo Candida albicans, Helicobacter pylori, Hepatitis C virus itd. Prethodne studije sprovedene unutar porodice su ukazale na postojanje genetičke predispozicije za razvoj OLP-a. Dodatno, OLP se često smatra i premalignom oralnom lezijom, iako je asocijacija sa nastankom oralnog karcinoma kontroverzna prema literaturnim podacima. Receptori slični Toll-u (Engl. Toll-Like Receptors - TLRs) predstavljaju veliku klasu receptora koji su uključeni u urođeni i adaptivni imuni odgovor. TLRs vezuju brojne egzogene i endogene antigene prepoznavanjem konzervisanih molekularnih obrazaca patogena (Engl. Pathogen Associated Molecular Patterns - PAMPs. Nakon aktivacije TLR, pokreću se nishodni molekulli u signalnom putu, što dovodi do ekspresije pro-inflamatornih gena. Prethodne studije su ukazale na značajnu ulogu koju TLR receptori imaju u patogenezi infekcije, inflamacije, oštećenja tkiva i nastanka kancera. U TLR genima je identifikovan veliki broj polimorfizama nukleotidne sekvence (Engl. Single Nucleotide Polymorphism – SNP). Moglo bi se pretpostaviti da polimorfizmi mogu uticati na funkcionalnost TLR receptora i povišavati/snižavati rizik za nastanak hronične infekcije. Kako je oralna mukoza direktno izložena mikroorganizmima koji mogu biti prepoznati od strane TLRova, prisustvo SNP-ova u TLR genima bi moglo imati važnu ulogu u patogenezi oralnog lihen planusa. Cilj. Cilj ove doktorske disertacije je bilo utvrđivanje postojanja asocijacije između polimorfizama TLR2 (rs3804099), TLR3 (rs3775291, rs5743312), TLR4 (rs4986791, rs4986790) i CD14 (rs2569190) gena sa rizikom za razvoj i kliničkim formama oralnog lihen planusa, kao i etiološkim faktorima. Dodatno, cilj je bila i identifikacija haplotipskih blokova u studijskoj grupi i asocijacije između registrovanih haplotipova sa rizikom za nastanak oralnog lihen planusa...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Udruženost poliformizma gena TLRs 2,3,4 i CD14 kod bolesnika sa oralnim lihen planusom (OLP)",
url = "https://hdl.handle.net/21.15107/rcub_nardus_5020"
}
Stanimirović, D.. (2014). Udruženost poliformizma gena TLRs 2,3,4 i CD14 kod bolesnika sa oralnim lihen planusom (OLP). 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_5020
Stanimirović D. Udruženost poliformizma gena TLRs 2,3,4 i CD14 kod bolesnika sa oralnim lihen planusom (OLP). 2014;.
https://hdl.handle.net/21.15107/rcub_nardus_5020 .
Stanimirović, Dragan, "Udruženost poliformizma gena TLRs 2,3,4 i CD14 kod bolesnika sa oralnim lihen planusom (OLP)" (2014),
https://hdl.handle.net/21.15107/rcub_nardus_5020 .

TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk

Stanimirović, Dragan; Zeljić, Katarina; Janković, Ljiljana; Magić, Marko; Hadži-Mihailović, Miloš; Magić, Zvonko

(Wiley-Blackwell, Hoboken, 2013)

TY  - JOUR
AU  - Stanimirović, Dragan
AU  - Zeljić, Katarina
AU  - Janković, Ljiljana
AU  - Magić, Marko
AU  - Hadži-Mihailović, Miloš
AU  - Magić, Zvonko
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1818
AB  - The aim of this study was to assess whether polymorphisms in toll-like receptor (TLR) and cluster of differentiation 14 (CD14) genes are associated with oral lichen planus (OLP) risk and clinical course of the disease. The study group consisted of 101 patients with confirmed OLP and 104 healthy blood donors without systemic or oral mucosal diseases. Single nucleotide polymorphisms of TLR2 (rs3804099), TLR3 (rs3775291 and rs5743312), TLR4 (rs4986790 and rs4986791), and CD14 (rs2569190) genes were genotyped using real-time PCR or PCR-restriction fragment length polymorphism (PCR-RFLP). The rs5743312 TLR3 gene polymorphism was associated with increased OLP risk in comparison with the wild type genotype (OR = 15.984, P = 0.011). No association with OLP risk was observed for the polymorphisms studied in TLR2, TLR4 and CD14 genes or for the rs3775291 polymorphism of the TLR3 gene. The polymorphisms of the TLR3 gene were in linkage disequilibrium (D ' = 1, r(2) = 0.1). Identified haplotypes were not associated with the risk of OLP. The findings of the current study suggest that the TT genotype of the rs5743312 TLR3 gene polymorphism may play a significant role in the aetiology of OLP.
PB  - Wiley-Blackwell, Hoboken
T2  - European Journal of Oral Sciences
T1  - TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk
VL  - 121
IS  - 5
SP  - 421
EP  - 426
DO  - 10.1111/eos.12074
ER  - 
@article{
author = "Stanimirović, Dragan and Zeljić, Katarina and Janković, Ljiljana and Magić, Marko and Hadži-Mihailović, Miloš and Magić, Zvonko",
year = "2013",
abstract = "The aim of this study was to assess whether polymorphisms in toll-like receptor (TLR) and cluster of differentiation 14 (CD14) genes are associated with oral lichen planus (OLP) risk and clinical course of the disease. The study group consisted of 101 patients with confirmed OLP and 104 healthy blood donors without systemic or oral mucosal diseases. Single nucleotide polymorphisms of TLR2 (rs3804099), TLR3 (rs3775291 and rs5743312), TLR4 (rs4986790 and rs4986791), and CD14 (rs2569190) genes were genotyped using real-time PCR or PCR-restriction fragment length polymorphism (PCR-RFLP). The rs5743312 TLR3 gene polymorphism was associated with increased OLP risk in comparison with the wild type genotype (OR = 15.984, P = 0.011). No association with OLP risk was observed for the polymorphisms studied in TLR2, TLR4 and CD14 genes or for the rs3775291 polymorphism of the TLR3 gene. The polymorphisms of the TLR3 gene were in linkage disequilibrium (D ' = 1, r(2) = 0.1). Identified haplotypes were not associated with the risk of OLP. The findings of the current study suggest that the TT genotype of the rs5743312 TLR3 gene polymorphism may play a significant role in the aetiology of OLP.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "European Journal of Oral Sciences",
title = "TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk",
volume = "121",
number = "5",
pages = "421-426",
doi = "10.1111/eos.12074"
}
Stanimirović, D., Zeljić, K., Janković, L., Magić, M., Hadži-Mihailović, M.,& Magić, Z.. (2013). TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk. in European Journal of Oral Sciences
Wiley-Blackwell, Hoboken., 121(5), 421-426.
https://doi.org/10.1111/eos.12074
Stanimirović D, Zeljić K, Janković L, Magić M, Hadži-Mihailović M, Magić Z. TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk. in European Journal of Oral Sciences. 2013;121(5):421-426.
doi:10.1111/eos.12074 .
Stanimirović, Dragan, Zeljić, Katarina, Janković, Ljiljana, Magić, Marko, Hadži-Mihailović, Miloš, Magić, Zvonko, "TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk" in European Journal of Oral Sciences, 121, no. 5 (2013):421-426,
https://doi.org/10.1111/eos.12074 . .
15
9
14

Clinical and psychiatric manifestations of burning mouth syndrome

Mijajlović, Milija; Zidverc-Trajković, Jasna; Stanimirović, Dragan; Janković, Ljiljana; Šternić, Nadežda

(Klinički centar - Institut za neurologiju, Beograd i Institut za psihijatriju, Beograd, 2011)

TY  - JOUR
AU  - Mijajlović, Milija
AU  - Zidverc-Trajković, Jasna
AU  - Stanimirović, Dragan
AU  - Janković, Ljiljana
AU  - Šternić, Nadežda
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1653
AB  - According to International Headache Society (IHS) classification, burning mouth syndrome (BMS) is intra oral burning sensation without obvious medical and dental cause. IHS diagnostic criteria of the disorder include the presence of burning oral sensation during the most period of day without obvious changes of oral mucosa. Local and systemic causes have to be excluded by appropriate diagnostic procedures. Subjective feeling of dry mouth, paraesthesia and taste changes could be associated symptoms. Estimated prevalence of BMS in general population varies between 1 and 15% and the disorder is seven times more common in females. This condition is probably of multifactor origin, oft en idiopathic, and its etiology and pathogenesis has not been elucidated completely yet. More recently, increasing attention has been given to the altered perception of sensory functions as well as to the changes in the psychological profile of many BMS patients. As a result, both disturbances should be included in the clinical spectrum of BMS. BMS represents a disorder with a poor prognosis in terms of quality of life and treatment possibilities. As a result, BMS subjects continue to be high consumers of healthcare resources. As in the other chronic pain conditions it has been reported that depression and anxiety are strongly associated with BMS and that they are significantly more frequent in BMS patients than in non-BMS subjects.
AB  - Prema međunarodnoj klasifikaciji glavobolja Internacionalnog društva za glavobolje (International Headache Society-IHS), sindrom pečenja usta (burning mouth syndrome-BMS) predstavlja osećaj pečenja u usnoj duplji, a bez očiglednog medicinskog ili stomatološkog uzroka. IHS dijagnostički kriterijumi za ovaj poremećaj uključuju prisustvo senzacije pečenja u usnoj duplji za vreme najvećeg perioda dana, bez vidljivih promena sluznice usne duplje. Lokalni i sistemski uzroci moraju biti isključeni primenom odgovarajućih dijagnostičkih procedura. Subjektivni osećaj suvoće usta, parestezija i izmena osećaja ukusa mogu biti udruženi simptomi. Procenjena prevalenca BMS u opštoj populaciji varira između 1 i 15%, a poremećaj je sedam puta češći kod žena. Ovaj poremećaj je verovatno multifaktorijelnog porekla, često idiopatski, a njegova etiologija i patogeneza nisu u potpunosti razjašnjeni. U skorašnjim studijama, posebno se ističe značaj izmenjene percepcije senzornih funkcija i sistema kao i specifična promena psihološkog profi la mnogih pacijenata sa BMS. Zbog toga se preporučuje da oba navedena poremećaja budu uključena u klinički raznovrstan spektar BMS. BMS ima lošu prognozu u pogledu kvaliteta života obolelih i terapijskih mogućnosti, a kao rezultat ovaj poremećaj predstavlja veliki socio-ekonomski i medicinski problem. Kao i kod drugih hroničnih bolnih stanja, postoji značajna udruženost BMS sa depresijom i anksioznošću. Ovi ali i drugi psihijatrijski i psihološki poremećaji su značajno češći kod pacijenata sa BMS u odnosu na zdravu populaciju.
PB  - Klinički centar - Institut za neurologiju, Beograd i Institut za psihijatriju, Beograd
T2  - Aktuelnosti iz neurologije, psihijatrije i graničnih područja
T1  - Clinical and psychiatric manifestations of burning mouth syndrome
T1  - Kliničke i psihijatrijske manifestacije sindroma pečenja usta
VL  - 19
IS  - 3-4
SP  - 37
EP  - 43
UR  - https://hdl.handle.net/21.15107/rcub_smile_1653
ER  - 
@article{
author = "Mijajlović, Milija and Zidverc-Trajković, Jasna and Stanimirović, Dragan and Janković, Ljiljana and Šternić, Nadežda",
year = "2011",
abstract = "According to International Headache Society (IHS) classification, burning mouth syndrome (BMS) is intra oral burning sensation without obvious medical and dental cause. IHS diagnostic criteria of the disorder include the presence of burning oral sensation during the most period of day without obvious changes of oral mucosa. Local and systemic causes have to be excluded by appropriate diagnostic procedures. Subjective feeling of dry mouth, paraesthesia and taste changes could be associated symptoms. Estimated prevalence of BMS in general population varies between 1 and 15% and the disorder is seven times more common in females. This condition is probably of multifactor origin, oft en idiopathic, and its etiology and pathogenesis has not been elucidated completely yet. More recently, increasing attention has been given to the altered perception of sensory functions as well as to the changes in the psychological profile of many BMS patients. As a result, both disturbances should be included in the clinical spectrum of BMS. BMS represents a disorder with a poor prognosis in terms of quality of life and treatment possibilities. As a result, BMS subjects continue to be high consumers of healthcare resources. As in the other chronic pain conditions it has been reported that depression and anxiety are strongly associated with BMS and that they are significantly more frequent in BMS patients than in non-BMS subjects., Prema međunarodnoj klasifikaciji glavobolja Internacionalnog društva za glavobolje (International Headache Society-IHS), sindrom pečenja usta (burning mouth syndrome-BMS) predstavlja osećaj pečenja u usnoj duplji, a bez očiglednog medicinskog ili stomatološkog uzroka. IHS dijagnostički kriterijumi za ovaj poremećaj uključuju prisustvo senzacije pečenja u usnoj duplji za vreme najvećeg perioda dana, bez vidljivih promena sluznice usne duplje. Lokalni i sistemski uzroci moraju biti isključeni primenom odgovarajućih dijagnostičkih procedura. Subjektivni osećaj suvoće usta, parestezija i izmena osećaja ukusa mogu biti udruženi simptomi. Procenjena prevalenca BMS u opštoj populaciji varira između 1 i 15%, a poremećaj je sedam puta češći kod žena. Ovaj poremećaj je verovatno multifaktorijelnog porekla, često idiopatski, a njegova etiologija i patogeneza nisu u potpunosti razjašnjeni. U skorašnjim studijama, posebno se ističe značaj izmenjene percepcije senzornih funkcija i sistema kao i specifična promena psihološkog profi la mnogih pacijenata sa BMS. Zbog toga se preporučuje da oba navedena poremećaja budu uključena u klinički raznovrstan spektar BMS. BMS ima lošu prognozu u pogledu kvaliteta života obolelih i terapijskih mogućnosti, a kao rezultat ovaj poremećaj predstavlja veliki socio-ekonomski i medicinski problem. Kao i kod drugih hroničnih bolnih stanja, postoji značajna udruženost BMS sa depresijom i anksioznošću. Ovi ali i drugi psihijatrijski i psihološki poremećaji su značajno češći kod pacijenata sa BMS u odnosu na zdravu populaciju.",
publisher = "Klinički centar - Institut za neurologiju, Beograd i Institut za psihijatriju, Beograd",
journal = "Aktuelnosti iz neurologije, psihijatrije i graničnih područja",
title = "Clinical and psychiatric manifestations of burning mouth syndrome, Kliničke i psihijatrijske manifestacije sindroma pečenja usta",
volume = "19",
number = "3-4",
pages = "37-43",
url = "https://hdl.handle.net/21.15107/rcub_smile_1653"
}
Mijajlović, M., Zidverc-Trajković, J., Stanimirović, D., Janković, L.,& Šternić, N.. (2011). Clinical and psychiatric manifestations of burning mouth syndrome. in Aktuelnosti iz neurologije, psihijatrije i graničnih područja
Klinički centar - Institut za neurologiju, Beograd i Institut za psihijatriju, Beograd., 19(3-4), 37-43.
https://hdl.handle.net/21.15107/rcub_smile_1653
Mijajlović M, Zidverc-Trajković J, Stanimirović D, Janković L, Šternić N. Clinical and psychiatric manifestations of burning mouth syndrome. in Aktuelnosti iz neurologije, psihijatrije i graničnih područja. 2011;19(3-4):37-43.
https://hdl.handle.net/21.15107/rcub_smile_1653 .
Mijajlović, Milija, Zidverc-Trajković, Jasna, Stanimirović, Dragan, Janković, Ljiljana, Šternić, Nadežda, "Clinical and psychiatric manifestations of burning mouth syndrome" in Aktuelnosti iz neurologije, psihijatrije i graničnih područja, 19, no. 3-4 (2011):37-43,
https://hdl.handle.net/21.15107/rcub_smile_1653 .

The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals

Janković, Saša; Aleksić, Zoran; Nikolić-Jakoba, Nataša; Stanimirović, Dragan; Stojić, Ž.; Pucar, Ana; Hadži-Mihailović, Miloš

(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2010)

TY  - JOUR
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Nikolić-Jakoba, Nataša
AU  - Stanimirović, Dragan
AU  - Stojić, Ž.
AU  - Pucar, Ana
AU  - Hadži-Mihailović, Miloš
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1585
AB  - Periodontal disease is a chronic, multi-factorial disease of the tissues supporting the teeth. Periodontitis in companion animals is an almost identical disease to that in humans in terms of disease course and clinical presentation. Receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) are bioactive molecules that control bone resorption. This study aims to evaluate the effect of Chlorhexidine (CXD) on the RANKL and OPG expressions in gingival crevicular fluid (GCF) collected from subjects with chronic periodontitis. GCF was obtained from subjects with chronic periodontitis.10 subjects (CXD1) rinsed the mouth with 0.12% CXD, 10 subjects (CXD2) utilized 0.20% CXD and the last 10 (PL) used Placebo solution for 7 days. RANKL and OPG concentrations in GCF were measured by enzyme-linked immunosorbent assays ELISA at baseline and after 7 days. Periodontal clinical variables: clinical attachment loss (CAL), probing pocket depth (PPD), papilla-bleeding index (PBI) were evaluated in all groups. After 7 days in CXD1 and CXD2 group RANKL/OPG ratio exhibited a significant decrease (p lt 0.05) in contrast to the PL group where results showed similar values of RANKL/OPG ratio at baseline and after the observation period. RANKL/OPG ratio was positively correlated with PPD, CAL and PBI before and after the observation period in both Chlorhexidine (CXD1, CXD2) groups. In an existing inflammatory response, chlorhexidine reduced the level of periodontal inflammation, which leads to reduction of RANKL/OPG relative ratio. Decrease of RANKL/OPG ratio will apparently induce maintenance of alveolar bone and slow down periodontal tissue breakdown.
AB  - Parodontopatije su hronična, multikauzalna oboljenja potpornog aparata zuba. Parodontalna oboljenja koja srećemo kod kućnih ljubimaca su prema toku i kliničkoj slici skoro identična onima koje se javljaju kod ljudi. RANKL i osteoprotegerin (OPG) su bioaktivni molekuli koji kontrolišu koštanu resorpciju. Cilj ove studije je evaluacija efekata hlorheksidina na ekspresiju RANKL-a i OPG-a u gingivalnoj tečnosti (GT) uzetoj od pacijenata sa hroničnom parodontopatijom. 10 pacijenata (CXD1) su ispirali usta sa 0.12% CXD, 10 pacijenata (CXD2) su koristili 0.20% CXD i poslednjih 10 pacijenata (PL) su koristili placebo rastvor 7 dana. RANKL i OPG koncentracije u GT su merene ELISA testom na početku i posle sedam dana. Parodontalni klinički parametri CAL, PPD i PBI su evaluirani u svim grupama. Posle 7 dana u CXD1 i CXD2 grupi RANKL/OPG odnos je pokazao signifikantno smanjenje (p lt 0.05) u poređenju sa PL grupom gde su zabaleženi slični rezultati na početku i nakon opservacionog perioda. RANKL/OPG odnos je pokazao pozitivnu korelaciju sa vrednostima PPD-a, CAL-a i PBI-a pre i nakon observacionog perioda u obe eksperimentalne grupe (CXD1, CXD2). U prisutnom inflamatornom odgovoru hlorheksidin je redukovao nivo inflamacije, što je uslovilo redukciju RANKL/OPG odnosa. Rezultati istraživanja dokazuju da koncentracija hlorheksidina ne utiče statistički značajno na smanjenje RANKL/OPG odnosa.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals
T1  - Efekat hlorheksidina na ekspresiju receptor aktivatora NF-kb liganda (RANKL) i osteoprotežerina (OPG) kod ljudi i kućnih ljubimaca
VL  - 60
IS  - 5-6
SP  - 641
EP  - 652
DO  - 10.2298/AVB1006641J
ER  - 
@article{
author = "Janković, Saša and Aleksić, Zoran and Nikolić-Jakoba, Nataša and Stanimirović, Dragan and Stojić, Ž. and Pucar, Ana and Hadži-Mihailović, Miloš",
year = "2010",
abstract = "Periodontal disease is a chronic, multi-factorial disease of the tissues supporting the teeth. Periodontitis in companion animals is an almost identical disease to that in humans in terms of disease course and clinical presentation. Receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) are bioactive molecules that control bone resorption. This study aims to evaluate the effect of Chlorhexidine (CXD) on the RANKL and OPG expressions in gingival crevicular fluid (GCF) collected from subjects with chronic periodontitis. GCF was obtained from subjects with chronic periodontitis.10 subjects (CXD1) rinsed the mouth with 0.12% CXD, 10 subjects (CXD2) utilized 0.20% CXD and the last 10 (PL) used Placebo solution for 7 days. RANKL and OPG concentrations in GCF were measured by enzyme-linked immunosorbent assays ELISA at baseline and after 7 days. Periodontal clinical variables: clinical attachment loss (CAL), probing pocket depth (PPD), papilla-bleeding index (PBI) were evaluated in all groups. After 7 days in CXD1 and CXD2 group RANKL/OPG ratio exhibited a significant decrease (p lt 0.05) in contrast to the PL group where results showed similar values of RANKL/OPG ratio at baseline and after the observation period. RANKL/OPG ratio was positively correlated with PPD, CAL and PBI before and after the observation period in both Chlorhexidine (CXD1, CXD2) groups. In an existing inflammatory response, chlorhexidine reduced the level of periodontal inflammation, which leads to reduction of RANKL/OPG relative ratio. Decrease of RANKL/OPG ratio will apparently induce maintenance of alveolar bone and slow down periodontal tissue breakdown., Parodontopatije su hronična, multikauzalna oboljenja potpornog aparata zuba. Parodontalna oboljenja koja srećemo kod kućnih ljubimaca su prema toku i kliničkoj slici skoro identična onima koje se javljaju kod ljudi. RANKL i osteoprotegerin (OPG) su bioaktivni molekuli koji kontrolišu koštanu resorpciju. Cilj ove studije je evaluacija efekata hlorheksidina na ekspresiju RANKL-a i OPG-a u gingivalnoj tečnosti (GT) uzetoj od pacijenata sa hroničnom parodontopatijom. 10 pacijenata (CXD1) su ispirali usta sa 0.12% CXD, 10 pacijenata (CXD2) su koristili 0.20% CXD i poslednjih 10 pacijenata (PL) su koristili placebo rastvor 7 dana. RANKL i OPG koncentracije u GT su merene ELISA testom na početku i posle sedam dana. Parodontalni klinički parametri CAL, PPD i PBI su evaluirani u svim grupama. Posle 7 dana u CXD1 i CXD2 grupi RANKL/OPG odnos je pokazao signifikantno smanjenje (p lt 0.05) u poređenju sa PL grupom gde su zabaleženi slični rezultati na početku i nakon opservacionog perioda. RANKL/OPG odnos je pokazao pozitivnu korelaciju sa vrednostima PPD-a, CAL-a i PBI-a pre i nakon observacionog perioda u obe eksperimentalne grupe (CXD1, CXD2). U prisutnom inflamatornom odgovoru hlorheksidin je redukovao nivo inflamacije, što je uslovilo redukciju RANKL/OPG odnosa. Rezultati istraživanja dokazuju da koncentracija hlorheksidina ne utiče statistički značajno na smanjenje RANKL/OPG odnosa.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals, Efekat hlorheksidina na ekspresiju receptor aktivatora NF-kb liganda (RANKL) i osteoprotežerina (OPG) kod ljudi i kućnih ljubimaca",
volume = "60",
number = "5-6",
pages = "641-652",
doi = "10.2298/AVB1006641J"
}
Janković, S., Aleksić, Z., Nikolić-Jakoba, N., Stanimirović, D., Stojić, Ž., Pucar, A.,& Hadži-Mihailović, M.. (2010). The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 60(5-6), 641-652.
https://doi.org/10.2298/AVB1006641J
Janković S, Aleksić Z, Nikolić-Jakoba N, Stanimirović D, Stojić Ž, Pucar A, Hadži-Mihailović M. The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals. in Acta veterinaria. 2010;60(5-6):641-652.
doi:10.2298/AVB1006641J .
Janković, Saša, Aleksić, Zoran, Nikolić-Jakoba, Nataša, Stanimirović, Dragan, Stojić, Ž., Pucar, Ana, Hadži-Mihailović, Miloš, "The effect of chlorhexidine on the receptor activator of NF-kb ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals" in Acta veterinaria, 60, no. 5-6 (2010):641-652,
https://doi.org/10.2298/AVB1006641J . .

Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome

Zidverc-Trajković, Jasna; Stanimirović, Dragan; Obrenović, Radmila; Tajti, Janos; Vecsei, Laszlo; Gardi, Janos; Nemeth, Jozsef; Mijajlović, Milija; Šternić, Nadežda; Janković, Ljiljana

(Wiley, Hoboken, 2009)

TY  - JOUR
AU  - Zidverc-Trajković, Jasna
AU  - Stanimirović, Dragan
AU  - Obrenović, Radmila
AU  - Tajti, Janos
AU  - Vecsei, Laszlo
AU  - Gardi, Janos
AU  - Nemeth, Jozsef
AU  - Mijajlović, Milija
AU  - Šternić, Nadežda
AU  - Janković, Ljiljana
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1513
AB  - Burning mouth syndrome (BMS) is an intraoral burning sensation for which no medical or dental cause can be found. Recent studies suggest that primary neuropathic dysfunction might be involved in the pathogenesis of BMS. Calcitonin gene-related peptide (CGRP) plays an important role in the development of pain and serves as a biological marker of trigeminovascular activation. The aim of this study was to determine the levels of CGRP in the saliva of BMS patients and estimate the trigeminovascular activation in BMS. CGRP levels were measured, by RIA method in 78 BMS patients and 16 healthy subjects. The levels of CGRP were non-significantly decreased in BMS patients in comparison to healthy subjects. These results suggest that trigeminal nerve degeneration may be the underlying cause of BMS.
PB  - Wiley, Hoboken
T2  - Journal of Oral Pathology & Medicine
T1  - Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome
VL  - 38
IS  - 1
SP  - 29
EP  - 33
DO  - 10.1111/j.1600-0714.2008.00721.x
ER  - 
@article{
author = "Zidverc-Trajković, Jasna and Stanimirović, Dragan and Obrenović, Radmila and Tajti, Janos and Vecsei, Laszlo and Gardi, Janos and Nemeth, Jozsef and Mijajlović, Milija and Šternić, Nadežda and Janković, Ljiljana",
year = "2009",
abstract = "Burning mouth syndrome (BMS) is an intraoral burning sensation for which no medical or dental cause can be found. Recent studies suggest that primary neuropathic dysfunction might be involved in the pathogenesis of BMS. Calcitonin gene-related peptide (CGRP) plays an important role in the development of pain and serves as a biological marker of trigeminovascular activation. The aim of this study was to determine the levels of CGRP in the saliva of BMS patients and estimate the trigeminovascular activation in BMS. CGRP levels were measured, by RIA method in 78 BMS patients and 16 healthy subjects. The levels of CGRP were non-significantly decreased in BMS patients in comparison to healthy subjects. These results suggest that trigeminal nerve degeneration may be the underlying cause of BMS.",
publisher = "Wiley, Hoboken",
journal = "Journal of Oral Pathology & Medicine",
title = "Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome",
volume = "38",
number = "1",
pages = "29-33",
doi = "10.1111/j.1600-0714.2008.00721.x"
}
Zidverc-Trajković, J., Stanimirović, D., Obrenović, R., Tajti, J., Vecsei, L., Gardi, J., Nemeth, J., Mijajlović, M., Šternić, N.,& Janković, L.. (2009). Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome. in Journal of Oral Pathology & Medicine
Wiley, Hoboken., 38(1), 29-33.
https://doi.org/10.1111/j.1600-0714.2008.00721.x
Zidverc-Trajković J, Stanimirović D, Obrenović R, Tajti J, Vecsei L, Gardi J, Nemeth J, Mijajlović M, Šternić N, Janković L. Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome. in Journal of Oral Pathology & Medicine. 2009;38(1):29-33.
doi:10.1111/j.1600-0714.2008.00721.x .
Zidverc-Trajković, Jasna, Stanimirović, Dragan, Obrenović, Radmila, Tajti, Janos, Vecsei, Laszlo, Gardi, Janos, Nemeth, Jozsef, Mijajlović, Milija, Šternić, Nadežda, Janković, Ljiljana, "Calcitonin gene-related peptide levels in saliva of patients with burning mouth syndrome" in Journal of Oral Pathology & Medicine, 38, no. 1 (2009):29-33,
https://doi.org/10.1111/j.1600-0714.2008.00721.x . .
37
21
31

Karakteristike i terapijske mogućnosti sindroma pečenja usta

Stanimirović, Dragan

(Univerzitet u Beogradu, Stomatološki fakultet, 2009)

TY  - THES
AU  - Stanimirović, Dragan
PY  - 2009
UR  - https://plus.sr.cobiss.net/opac7/bib/1024166030
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/477
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Karakteristike i terapijske mogućnosti sindroma pečenja usta
UR  - https://hdl.handle.net/21.15107/rcub_smile_477
ER  - 
@mastersthesis{
author = "Stanimirović, Dragan",
year = "2009",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Karakteristike i terapijske mogućnosti sindroma pečenja usta",
url = "https://hdl.handle.net/21.15107/rcub_smile_477"
}
Stanimirović, D.. (2009). Karakteristike i terapijske mogućnosti sindroma pečenja usta. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_477
Stanimirović D. Karakteristike i terapijske mogućnosti sindroma pečenja usta. 2009;.
https://hdl.handle.net/21.15107/rcub_smile_477 .
Stanimirović, Dragan, "Karakteristike i terapijske mogućnosti sindroma pečenja usta" (2009),
https://hdl.handle.net/21.15107/rcub_smile_477 .