TY  - JOUR
AU  - Dželetović, Bojan
AU  - Aleksić, Nikola
AU  - Radak, Đorđe
AU  - Stratimirović, Đorđe
AU  - Đukić, Ljiljana
AU  - Stojić, Dragica
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2499
AB  - Introduction: Age-related changes of dental pulp tissue and atherosclerosis of carotid arteries as its feeding arteries could influence the functionality of pulpal circulation. The objective of our study was to evaluate the effect of aging (physiological process) and carotid bifurcation atherosclerosis (pathologic process) on the pulpal microcirculatory system using multifractal analysis of the laser Doppler flowmetry signal. Methods: Three groups of 10 subjects were enrolled in the study: the young group (healthy subjects, 20-25 years), the middle-aged group (healthy subjects, 50-60 years), and the clinical group (subjects with carotid bifurcation atherosclerosis, 50-60 years). Pulpal blood flow (PBF) signals recorded by laser Doppler flowmetry were assessed by multifractal analysis that estimates Holder exponents of the signal. PBF levels, the average mean values, and the range of Holder exponents were obtained. Results: PBF levels were significantly higher in the young group compared with the middle-aged and clinical groups, and the difference between the middle-aged and clinical groups was not statistically significant. The range of the Holder exponents was narrower in the middle-aged and clinical groups than in the young group and narrower in the clinical group than in the middle-aged group. The average mean value of Holder exponents was significantly higher in the young group than in the middle-aged and clinical groups, whereas there was no significant difference between the middle-aged and clinical groups. Conclusions: Our study investigating the multifractality of the PBF signal showed that the aging process and carotid atherosclerosis could affect the complex structure of PBF oscillations and contribute to a better understanding of pulpal hemodynamics.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - Effect of Aging and Carotid Atherosclerosis on Multifractality of Dental Pulp Blood Flow Oscillations
VL  - 46
IS  - 3
SP  - 358
EP  - 363
DO  - 10.1016/j.joen.2019.12.008
ER  - 

@article{
author = "Dželetović, Bojan and Aleksić, Nikola and Radak, Đorđe and Stratimirović, Đorđe and Đukić, Ljiljana and Stojić, Dragica",
year = "2020",
abstract = "Introduction: Age-related changes of dental pulp tissue and atherosclerosis of carotid arteries as its feeding arteries could influence the functionality of pulpal circulation. The objective of our study was to evaluate the effect of aging (physiological process) and carotid bifurcation atherosclerosis (pathologic process) on the pulpal microcirculatory system using multifractal analysis of the laser Doppler flowmetry signal. Methods: Three groups of 10 subjects were enrolled in the study: the young group (healthy subjects, 20-25 years), the middle-aged group (healthy subjects, 50-60 years), and the clinical group (subjects with carotid bifurcation atherosclerosis, 50-60 years). Pulpal blood flow (PBF) signals recorded by laser Doppler flowmetry were assessed by multifractal analysis that estimates Holder exponents of the signal. PBF levels, the average mean values, and the range of Holder exponents were obtained. Results: PBF levels were significantly higher in the young group compared with the middle-aged and clinical groups, and the difference between the middle-aged and clinical groups was not statistically significant. The range of the Holder exponents was narrower in the middle-aged and clinical groups than in the young group and narrower in the clinical group than in the middle-aged group. The average mean value of Holder exponents was significantly higher in the young group than in the middle-aged and clinical groups, whereas there was no significant difference between the middle-aged and clinical groups. Conclusions: Our study investigating the multifractality of the PBF signal showed that the aging process and carotid atherosclerosis could affect the complex structure of PBF oscillations and contribute to a better understanding of pulpal hemodynamics.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "Effect of Aging and Carotid Atherosclerosis on Multifractality of Dental Pulp Blood Flow Oscillations",
volume = "46",
number = "3",
pages = "358-363",
doi = "10.1016/j.joen.2019.12.008"
}

Dželetović, B., Aleksić, N., Radak, Đ., Stratimirović, Đ., Đukić, L.,& Stojić, D.. (2020). Effect of Aging and Carotid Atherosclerosis on Multifractality of Dental Pulp Blood Flow Oscillations. in Journal of Endodontics
Elsevier Science Inc, New York., 46(3), 358-363.
https://doi.org/10.1016/j.joen.2019.12.008

Dželetović B, Aleksić N, Radak Đ, Stratimirović Đ, Đukić L, Stojić D. Effect of Aging and Carotid Atherosclerosis on Multifractality of Dental Pulp Blood Flow Oscillations. in Journal of Endodontics. 2020;46(3):358-363.
doi:10.1016/j.joen.2019.12.008 .

Dželetović, Bojan, Aleksić, Nikola, Radak, Đorđe, Stratimirović, Đorđe, Đukić, Ljiljana, Stojić, Dragica, "Effect of Aging and Carotid Atherosclerosis on Multifractality of Dental Pulp Blood Flow Oscillations" in Journal of Endodontics, 46, no. 3 (2020):358-363,
https://doi.org/10.1016/j.joen.2019.12.008 . .

TY  - JOUR
AU  - Dželetović, Bojan
AU  - Stratimirović, Đorđe
AU  - Stojić, Dragica
AU  - Đukić, Ljiljana
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1049
AB  - Aim To investigate the effect of ageing on control mechanisms of pulpal microcirculation using wavelet analysis and to calculate linear and nonlinear parameters of blood flow oscillations, in a healthy general population. Methodology Pulpal blood flow (PBF) oscillations were recorded on right maxillary central incisors using laser Doppler Flowmeter (PeriFlux PF 5001, Perimed, Jarfalla, Sweden) on a group of 10 young participants (20-25 years) and a group of 10 older adults (60-70 years). In total, 20 recordings were obtained for at least 20 min (one recording on one tooth per subject). Using wavelet spectral analysis, the amplitude and power were calculated as a linear and Hurst exponent as a nonlinear parameter of PBF oscillations. Differences between the two groups were assessed with the independent Student t-test. Results Mean PBF levels were significantly lower (P = 0.024) in older adults than in young participants. Relative amplitudes and powers corresponding to the myogenic (P = 0.046, P  lt  0.001, respectively) and neurogenic activity (P = 0.04, P = 0.01, respectively) were significantly higher, whereas values corresponding to the endothelial function (P = 0.04, P = 0.01, respectively) were significantly lower in older adults than in young participants. Hurst exponents of the total spectrum, myogenic and endothelial component (P  lt  0.001, P = 0.02, P  lt  0.001, respectively) of PBF oscillations were significantly lower in older adults in comparison to young participants. Conclusions At the level of pulpal microcirculation, ageing was associated with altered blood flow levels, the contribution of different control mechanisms to blood flow oscillations as well as the interaction of vascular smooth muscle and endothelium. Described changes of pulpal haemodynamics contribute to a better understanding of physiological behaviour and decreased adaptability of aged dental pulp to pathological stimuli.
PB  - Wiley, Hoboken
T2  - International Endodontic Journal
T1  - Linear and nonlinear analysis of dental pulp blood flow oscillations in ageing
DO  - 10.1111/iej.13306
ER  - 

@article{
author = "Dželetović, Bojan and Stratimirović, Đorđe and Stojić, Dragica and Đukić, Ljiljana",
year = "2020",
abstract = "Aim To investigate the effect of ageing on control mechanisms of pulpal microcirculation using wavelet analysis and to calculate linear and nonlinear parameters of blood flow oscillations, in a healthy general population. Methodology Pulpal blood flow (PBF) oscillations were recorded on right maxillary central incisors using laser Doppler Flowmeter (PeriFlux PF 5001, Perimed, Jarfalla, Sweden) on a group of 10 young participants (20-25 years) and a group of 10 older adults (60-70 years). In total, 20 recordings were obtained for at least 20 min (one recording on one tooth per subject). Using wavelet spectral analysis, the amplitude and power were calculated as a linear and Hurst exponent as a nonlinear parameter of PBF oscillations. Differences between the two groups were assessed with the independent Student t-test. Results Mean PBF levels were significantly lower (P = 0.024) in older adults than in young participants. Relative amplitudes and powers corresponding to the myogenic (P = 0.046, P  lt  0.001, respectively) and neurogenic activity (P = 0.04, P = 0.01, respectively) were significantly higher, whereas values corresponding to the endothelial function (P = 0.04, P = 0.01, respectively) were significantly lower in older adults than in young participants. Hurst exponents of the total spectrum, myogenic and endothelial component (P  lt  0.001, P = 0.02, P  lt  0.001, respectively) of PBF oscillations were significantly lower in older adults in comparison to young participants. Conclusions At the level of pulpal microcirculation, ageing was associated with altered blood flow levels, the contribution of different control mechanisms to blood flow oscillations as well as the interaction of vascular smooth muscle and endothelium. Described changes of pulpal haemodynamics contribute to a better understanding of physiological behaviour and decreased adaptability of aged dental pulp to pathological stimuli.",
publisher = "Wiley, Hoboken",
journal = "International Endodontic Journal",
title = "Linear and nonlinear analysis of dental pulp blood flow oscillations in ageing",
doi = "10.1111/iej.13306"
}

Dželetović, B., Stratimirović, Đ., Stojić, D.,& Đukić, L.. (2020). Linear and nonlinear analysis of dental pulp blood flow oscillations in ageing. in International Endodontic Journal
Wiley, Hoboken..
https://doi.org/10.1111/iej.13306

Dželetović B, Stratimirović Đ, Stojić D, Đukić L. Linear and nonlinear analysis of dental pulp blood flow oscillations in ageing. in International Endodontic Journal. 2020;.
doi:10.1111/iej.13306 .

Dželetović, Bojan, Stratimirović, Đorđe, Stojić, Dragica, Đukić, Ljiljana, "Linear and nonlinear analysis of dental pulp blood flow oscillations in ageing" in International Endodontic Journal (2020),
https://doi.org/10.1111/iej.13306 . .

TY  - JOUR
AU  - Krunić, Jelena
AU  - Stojanović, Nikola
AU  - Đukić, Ljiljana
AU  - Roganović, Jelena
AU  - Popović, Branka
AU  - Simić, Ivana
AU  - Stojić, Dragica
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2465
AB  - ObjectivesTo evaluate local effect of gaseous ozone on bacteria in deep carious lesions after incomplete caries removal, using chlorhexidine as control, and to investigate its effect on pulp vascular endothelial growth factor (VEGF), neuronal nitric oxide synthase (nNOS), and superoxide dismutase (SOD).Materials and methodsAntibacterial effect was evaluated in 48 teeth with diagnosed deep carious lesion. After incomplete caries removal, teeth were randomly allocated into two groups regarding the cavity disinfectant used: ozone (open system) or 2% chlorhexidine. Dentin samples were analyzed for the presence of total bacteria and Lactobacillus spp. by real-time quantitative polymerase chain reaction. For evaluation of ozone effect on dental pulp, 38 intact permanent teeth indicated for pulp removal/tooth extraction were included. After cavity preparation, teeth were randomly allocated into two groups: ozone group and control group. VEGF/nNOS level and SOD activity in dental pulp were determined by enzyme-linked immunosorbent assay and spectrophotometric method, respectively.ResultsOzone application decreased number of total bacteria (p=0.001) and Lactobacillus spp. (p lt 0.001), similarly to chlorhexidine. The VEGF (p lt 0.001) and nNOS (p=0.012) levels in dental pulp after ozone application were higher, while SOD activity was lower (p=0.001) comparing to those in control pulp.ConclusionsAntibacterial effect of ozone on residual bacteria after incomplete caries removal was similar to that of 2% chlorhexidine. Effect of ozone on pulp VEGF, nNOS, and SOD indicated its biocompatibility.Clinical relevanceOzone appears as effective and biocompatible cavity disinfectant in treatment of deep carious lesions by incomplete caries removal technique.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal
VL  - 23
IS  - 2
SP  - 785
EP  - 792
DO  - 10.1007/s00784-018-2495-x
ER  - 

@article{
author = "Krunić, Jelena and Stojanović, Nikola and Đukić, Ljiljana and Roganović, Jelena and Popović, Branka and Simić, Ivana and Stojić, Dragica",
year = "2019",
abstract = "ObjectivesTo evaluate local effect of gaseous ozone on bacteria in deep carious lesions after incomplete caries removal, using chlorhexidine as control, and to investigate its effect on pulp vascular endothelial growth factor (VEGF), neuronal nitric oxide synthase (nNOS), and superoxide dismutase (SOD).Materials and methodsAntibacterial effect was evaluated in 48 teeth with diagnosed deep carious lesion. After incomplete caries removal, teeth were randomly allocated into two groups regarding the cavity disinfectant used: ozone (open system) or 2% chlorhexidine. Dentin samples were analyzed for the presence of total bacteria and Lactobacillus spp. by real-time quantitative polymerase chain reaction. For evaluation of ozone effect on dental pulp, 38 intact permanent teeth indicated for pulp removal/tooth extraction were included. After cavity preparation, teeth were randomly allocated into two groups: ozone group and control group. VEGF/nNOS level and SOD activity in dental pulp were determined by enzyme-linked immunosorbent assay and spectrophotometric method, respectively.ResultsOzone application decreased number of total bacteria (p=0.001) and Lactobacillus spp. (p lt 0.001), similarly to chlorhexidine. The VEGF (p lt 0.001) and nNOS (p=0.012) levels in dental pulp after ozone application were higher, while SOD activity was lower (p=0.001) comparing to those in control pulp.ConclusionsAntibacterial effect of ozone on residual bacteria after incomplete caries removal was similar to that of 2% chlorhexidine. Effect of ozone on pulp VEGF, nNOS, and SOD indicated its biocompatibility.Clinical relevanceOzone appears as effective and biocompatible cavity disinfectant in treatment of deep carious lesions by incomplete caries removal technique.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal",
volume = "23",
number = "2",
pages = "785-792",
doi = "10.1007/s00784-018-2495-x"
}

Krunić, J., Stojanović, N., Đukić, L., Roganović, J., Popović, B., Simić, I.,& Stojić, D.. (2019). Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 23(2), 785-792.
https://doi.org/10.1007/s00784-018-2495-x

Krunić J, Stojanović N, Đukić L, Roganović J, Popović B, Simić I, Stojić D. Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal. in Clinical Oral Investigations. 2019;23(2):785-792.
doi:10.1007/s00784-018-2495-x .

Krunić, Jelena, Stojanović, Nikola, Đukić, Ljiljana, Roganović, Jelena, Popović, Branka, Simić, Ivana, Stojić, Dragica, "Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal" in Clinical Oral Investigations, 23, no. 2 (2019):785-792,
https://doi.org/10.1007/s00784-018-2495-x . .

TY  - JOUR
AU  - Milić, Marija
AU  - Brković, Božidar
AU  - Kršljak, Elena
AU  - Stojić, Dragica
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2179
AB  - The pulpal anesthetic and cardiovascular parameters obtained by 2 % lidocaine with epinephrine (LE; 1:80,000) or clonidine (LC; 15 mcg/ml) were studied in diabetes mellitus (DM) type 2 and healthy volunteers (72), after maxillary infiltration anesthesia. Onset and duration of pulpal anesthesia were measured by electric pulp tester; vasoconstrictive effect of used local anesthetic mixtures by laser Doppler flowmetry (LDF) through pulpal blood flow (PBF); systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were registered by electrocardiogram monitoring. Onset of pulpal anesthesia was shorter for LC than for LE in healthy, while it was not different in diabetic participants; duration of pulpal anesthesia was significantly longer in type 2 diabetic participants, regardless of used anesthetic mixture. Significant reduction of PBF with LE was observed during 45 min in healthy and 60 min in diabetic participants, while with LC such reduction was observed during 45 min in both groups. LE caused a significant increase of SBP in the 5th and 15th minutes in diabetic versus healthy participants, while LC decreased SBP from the 10th to 60th minutes in healthy versus diabetic participants. DM type 2 influences duration of maxillary infiltration anesthesia obtained with LE and LC, and systolic blood pressure during LE anesthesia. The obtained results provide elements for future protocols concerning intraoral local anesthesia in DM type 2 patients.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers
VL  - 20
IS  - 6
SP  - 1283
EP  - 1293
DO  - 10.1007/s00784-015-1610-5
ER  - 

@article{
author = "Milić, Marija and Brković, Božidar and Kršljak, Elena and Stojić, Dragica",
year = "2016",
abstract = "The pulpal anesthetic and cardiovascular parameters obtained by 2 % lidocaine with epinephrine (LE; 1:80,000) or clonidine (LC; 15 mcg/ml) were studied in diabetes mellitus (DM) type 2 and healthy volunteers (72), after maxillary infiltration anesthesia. Onset and duration of pulpal anesthesia were measured by electric pulp tester; vasoconstrictive effect of used local anesthetic mixtures by laser Doppler flowmetry (LDF) through pulpal blood flow (PBF); systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were registered by electrocardiogram monitoring. Onset of pulpal anesthesia was shorter for LC than for LE in healthy, while it was not different in diabetic participants; duration of pulpal anesthesia was significantly longer in type 2 diabetic participants, regardless of used anesthetic mixture. Significant reduction of PBF with LE was observed during 45 min in healthy and 60 min in diabetic participants, while with LC such reduction was observed during 45 min in both groups. LE caused a significant increase of SBP in the 5th and 15th minutes in diabetic versus healthy participants, while LC decreased SBP from the 10th to 60th minutes in healthy versus diabetic participants. DM type 2 influences duration of maxillary infiltration anesthesia obtained with LE and LC, and systolic blood pressure during LE anesthesia. The obtained results provide elements for future protocols concerning intraoral local anesthesia in DM type 2 patients.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers",
volume = "20",
number = "6",
pages = "1283-1293",
doi = "10.1007/s00784-015-1610-5"
}

Milić, M., Brković, B., Kršljak, E.,& Stojić, D.. (2016). Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 20(6), 1283-1293.
https://doi.org/10.1007/s00784-015-1610-5

Milić M, Brković B, Kršljak E, Stojić D. Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers. in Clinical Oral Investigations. 2016;20(6):1283-1293.
doi:10.1007/s00784-015-1610-5 .

Milić, Marija, Brković, Božidar, Kršljak, Elena, Stojić, Dragica, "Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers" in Clinical Oral Investigations, 20, no. 6 (2016):1283-1293,
https://doi.org/10.1007/s00784-015-1610-5 . .

TY  - JOUR
AU  - Milić, Marija
AU  - Brković, Božidar
AU  - Kršljak, Elena
AU  - Stojić, Dragica
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2149
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers (vol 20, pg 1283, 2016)
VL  - 20
IS  - 6
SP  - 1295
EP  - 1296
DO  - 10.1007/s00784-015-1628-8
ER  - 

@article{
author = "Milić, Marija and Brković, Božidar and Kršljak, Elena and Stojić, Dragica",
year = "2016",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers (vol 20, pg 1283, 2016)",
volume = "20",
number = "6",
pages = "1295-1296",
doi = "10.1007/s00784-015-1628-8"
}

Milić, M., Brković, B., Kršljak, E.,& Stojić, D.. (2016). Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers (vol 20, pg 1283, 2016). in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 20(6), 1295-1296.
https://doi.org/10.1007/s00784-015-1628-8

Milić M, Brković B, Kršljak E, Stojić D. Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers (vol 20, pg 1283, 2016). in Clinical Oral Investigations. 2016;20(6):1295-1296.
doi:10.1007/s00784-015-1628-8 .

Milić, Marija, Brković, Božidar, Kršljak, Elena, Stojić, Dragica, "Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers (vol 20, pg 1283, 2016)" in Clinical Oral Investigations, 20, no. 6 (2016):1295-1296,
https://doi.org/10.1007/s00784-015-1628-8 . .

TY  - JOUR
AU  - Roganović, Jelena
AU  - Đukić, Ljiljana
AU  - Kršljak, Elena
AU  - Tanić, Nasta
AU  - Stojić, Dragica
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1963
AB  - ObjectivesThe influence of experimental diabetes (alloxan, 100mgkg(-1)) was studied on rabbit parotid gland function. Material and MethodsCarbachol-induced parotid secretion in vivo, and in vitro quantification of inducible nitric oxide synthase (iNOS) mRNA expression, by real-time RT-PCR, and activity of superoxide dismutase (SOD) and total antioxidant capacity (TAC) in commercial colorimetric assays were measured in parotid glands of non-diabetic and diabetic rabbits. ResultsCarbachol-induced dose-dependent increase in parotid secretion significantly reduced in diabetic rabbits. Functional studies in the presence of muscarinic receptor and nitric oxide synthase (NOS) antagonists revealed that in M-3 receptor-mediated carbachol secretion, nitric oxide, deriving mainly from neuronal NOS (nNOS) in control, and iNOS in diabetic rabbits, was involved. Also, upregulation of iNOS mRNA expression and enhanced SOD activity and TAC were detected in diabetic glands. ConclusionsOur data suggest that decreased M-3 receptor-mediated parotid secretion in diabetic rabbits appears to be due to alterations in NO signaling, mainly due to iNOS induction, accompanied by elevated antioxidant response.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits
VL  - 21
IS  - 5
SP  - 634
EP  - 640
DO  - 10.1111/odi.12327
ER  - 

@article{
author = "Roganović, Jelena and Đukić, Ljiljana and Kršljak, Elena and Tanić, Nasta and Stojić, Dragica",
year = "2015",
abstract = "ObjectivesThe influence of experimental diabetes (alloxan, 100mgkg(-1)) was studied on rabbit parotid gland function. Material and MethodsCarbachol-induced parotid secretion in vivo, and in vitro quantification of inducible nitric oxide synthase (iNOS) mRNA expression, by real-time RT-PCR, and activity of superoxide dismutase (SOD) and total antioxidant capacity (TAC) in commercial colorimetric assays were measured in parotid glands of non-diabetic and diabetic rabbits. ResultsCarbachol-induced dose-dependent increase in parotid secretion significantly reduced in diabetic rabbits. Functional studies in the presence of muscarinic receptor and nitric oxide synthase (NOS) antagonists revealed that in M-3 receptor-mediated carbachol secretion, nitric oxide, deriving mainly from neuronal NOS (nNOS) in control, and iNOS in diabetic rabbits, was involved. Also, upregulation of iNOS mRNA expression and enhanced SOD activity and TAC were detected in diabetic glands. ConclusionsOur data suggest that decreased M-3 receptor-mediated parotid secretion in diabetic rabbits appears to be due to alterations in NO signaling, mainly due to iNOS induction, accompanied by elevated antioxidant response.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits",
volume = "21",
number = "5",
pages = "634-640",
doi = "10.1111/odi.12327"
}

Roganović, J., Đukić, L., Kršljak, E., Tanić, N.,& Stojić, D.. (2015). Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits. in Oral Diseases
Wiley, Hoboken., 21(5), 634-640.
https://doi.org/10.1111/odi.12327

Roganović J, Đukić L, Kršljak E, Tanić N, Stojić D. Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits. in Oral Diseases. 2015;21(5):634-640.
doi:10.1111/odi.12327 .

Roganović, Jelena, Đukić, Ljiljana, Kršljak, Elena, Tanić, Nasta, Stojić, Dragica, "Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits" in Oral Diseases, 21, no. 5 (2015):634-640,
https://doi.org/10.1111/odi.12327 . .

TY  - JOUR
AU  - Đukić, Ljiljana
AU  - Roganović, Jelena
AU  - Brajović, Milan
AU  - Bokonjić, Dejan
AU  - Stojić, Dragica
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1961
AB  - ObjectiveThe present cross-sectional study aimed to determine the effect of first-line anti-hypertensive drugs (enalapril, metoprolol, and combinations of enalapril with metoprolol and/or hydrochlorothiazide) on salivary gland function and salivary total antioxidant capacity (TAC) in hypertensive patients with/without diabetes mellitus (DM) type 2. Materials and MethodsSalivary gland function was measured as xerostomia (interview) and unstimulated whole saliva flow rate (UWSFR) in 447 subjects (387 hypertensive and 60 healthy). Salivary TAC was evaluated by spectrophotometric assay. ResultsEnalapril is not xerogenic, while metoprolol and drug combinations are. In the presence of DM type 2, all drugs, except metoprolol, had pronounced xerogenic effect. Binary logistic regression analysis found enalapril to be significantly associated with decreased risk of xerogenic effect development, while DM type 2 with increased risk. In the presence of enalapril in hypertensive patients with/without DM type 2 salivary TAC was similar to that in healthy subjects, while for metoprolol was reduced. ConclusionsEnalapril is not xerogenic but is antioxidant, which moderately reduces the risk of xerogenic effect development even in the presence of DM type 2. However, metoprolol and drug combinations exhibit xerogenic effect. In DM type 2, xerogenic effect of all drugs was pronounced except of metoprolol.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity
VL  - 21
IS  - 5
SP  - 619
EP  - 625
DO  - 10.1111/odi.12325
ER  - 

@article{
author = "Đukić, Ljiljana and Roganović, Jelena and Brajović, Milan and Bokonjić, Dejan and Stojić, Dragica",
year = "2015",
abstract = "ObjectiveThe present cross-sectional study aimed to determine the effect of first-line anti-hypertensive drugs (enalapril, metoprolol, and combinations of enalapril with metoprolol and/or hydrochlorothiazide) on salivary gland function and salivary total antioxidant capacity (TAC) in hypertensive patients with/without diabetes mellitus (DM) type 2. Materials and MethodsSalivary gland function was measured as xerostomia (interview) and unstimulated whole saliva flow rate (UWSFR) in 447 subjects (387 hypertensive and 60 healthy). Salivary TAC was evaluated by spectrophotometric assay. ResultsEnalapril is not xerogenic, while metoprolol and drug combinations are. In the presence of DM type 2, all drugs, except metoprolol, had pronounced xerogenic effect. Binary logistic regression analysis found enalapril to be significantly associated with decreased risk of xerogenic effect development, while DM type 2 with increased risk. In the presence of enalapril in hypertensive patients with/without DM type 2 salivary TAC was similar to that in healthy subjects, while for metoprolol was reduced. ConclusionsEnalapril is not xerogenic but is antioxidant, which moderately reduces the risk of xerogenic effect development even in the presence of DM type 2. However, metoprolol and drug combinations exhibit xerogenic effect. In DM type 2, xerogenic effect of all drugs was pronounced except of metoprolol.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity",
volume = "21",
number = "5",
pages = "619-625",
doi = "10.1111/odi.12325"
}

Đukić, L., Roganović, J., Brajović, M., Bokonjić, D.,& Stojić, D.. (2015). The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity. in Oral Diseases
Wiley, Hoboken., 21(5), 619-625.
https://doi.org/10.1111/odi.12325

Đukić L, Roganović J, Brajović M, Bokonjić D, Stojić D. The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity. in Oral Diseases. 2015;21(5):619-625.
doi:10.1111/odi.12325 .

Đukić, Ljiljana, Roganović, Jelena, Brajović, Milan, Bokonjić, Dejan, Stojić, Dragica, "The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity" in Oral Diseases, 21, no. 5 (2015):619-625,
https://doi.org/10.1111/odi.12325 . .

TY  - JOUR
AU  - Radović, Katarina
AU  - Ilić, Jugoslav
AU  - Roganović, Jelena
AU  - Stojić, Dragica
AU  - Brković, Božidar
AU  - Pudar, Georgina
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1939
AB  - Statement of problem. Diabetes mellitus type 2 is associated with a variety of oral mucosal changes, including an altered level of salivary vascular endothelial growth factor. However, the authors identified no studies concerning denture stomatitis and salivary vascular endothelial growth factor in immediate denture wearers with diabetes mellitus type 2. Purpose. The purpose of this study was to investigate the incidence of and risk factors for denture stomatitis in immediate complete denture wearers with and without diabetes mellitus type 2 and to investigate the relationship between levels of salivary vascular endothelial growth factor and clinical forms of denture stomatitis in both groups. Material and methods. Individuals without diabetes (n=42) or with diabetes mellitus type 2 (n=36) who were candidates for complete immediate dentures were included in the study. After 1 year of wearing relined immediate dentures, participants were evaluated for denture stomatitis and potential contributing factors. Salivary vascular endothelial growth factor levels were measured with enzyme-linked immunosorbent assays. Data were analyzed with the chi(2) test or the Student t test where appropriate, as well as with binary logistic regression analysis. Results. The incidence of denture stomatitis was 61% in participants with diabetes mellitus type 2 and 38% in those without diabetes. Low denture stability and diabetes mellitus type 2 were risk factors for denture stomatitis. Salivary vascular endothelial growth factor concentrations at the beginning of the study were 557.6 +/- 94.7 pg/mL in participants with diabetes mellitus type 2 and 103.5 +/- 21.6 pg/mL in those without diabetes. In Newton Type I and Newton Type II denture stomatitis, vascular endothelial growth factor levels were 460.9 +/- 55.4 pg/mL and 1445.2 +/- 422.1 pg/mL in individuals with diabetes and 73.2 +/- 10.0 pg/mL and 306.5 +/- 22.6 pg/mL in those without diabetes. Conclusions. Perceived denture stability and diabetes mellitus type 2 are independent risk factors for the occurrence of denture stomatitis. Altered salivary vascular endothelial growth factor levels and denture stomatitis are more prevalent in denture wearers with diabetes mellitus type 2.
PB  - Mosby-Elsevier, New York
T2  - Journal of Prosthetic Dentistry
T1  - Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes
VL  - 111
IS  - 5
SP  - 373
EP  - 379
DO  - 10.1016/j.prosdent.2013.07.019
ER  - 

@article{
author = "Radović, Katarina and Ilić, Jugoslav and Roganović, Jelena and Stojić, Dragica and Brković, Božidar and Pudar, Georgina",
year = "2014",
abstract = "Statement of problem. Diabetes mellitus type 2 is associated with a variety of oral mucosal changes, including an altered level of salivary vascular endothelial growth factor. However, the authors identified no studies concerning denture stomatitis and salivary vascular endothelial growth factor in immediate denture wearers with diabetes mellitus type 2. Purpose. The purpose of this study was to investigate the incidence of and risk factors for denture stomatitis in immediate complete denture wearers with and without diabetes mellitus type 2 and to investigate the relationship between levels of salivary vascular endothelial growth factor and clinical forms of denture stomatitis in both groups. Material and methods. Individuals without diabetes (n=42) or with diabetes mellitus type 2 (n=36) who were candidates for complete immediate dentures were included in the study. After 1 year of wearing relined immediate dentures, participants were evaluated for denture stomatitis and potential contributing factors. Salivary vascular endothelial growth factor levels were measured with enzyme-linked immunosorbent assays. Data were analyzed with the chi(2) test or the Student t test where appropriate, as well as with binary logistic regression analysis. Results. The incidence of denture stomatitis was 61% in participants with diabetes mellitus type 2 and 38% in those without diabetes. Low denture stability and diabetes mellitus type 2 were risk factors for denture stomatitis. Salivary vascular endothelial growth factor concentrations at the beginning of the study were 557.6 +/- 94.7 pg/mL in participants with diabetes mellitus type 2 and 103.5 +/- 21.6 pg/mL in those without diabetes. In Newton Type I and Newton Type II denture stomatitis, vascular endothelial growth factor levels were 460.9 +/- 55.4 pg/mL and 1445.2 +/- 422.1 pg/mL in individuals with diabetes and 73.2 +/- 10.0 pg/mL and 306.5 +/- 22.6 pg/mL in those without diabetes. Conclusions. Perceived denture stability and diabetes mellitus type 2 are independent risk factors for the occurrence of denture stomatitis. Altered salivary vascular endothelial growth factor levels and denture stomatitis are more prevalent in denture wearers with diabetes mellitus type 2.",
publisher = "Mosby-Elsevier, New York",
journal = "Journal of Prosthetic Dentistry",
title = "Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes",
volume = "111",
number = "5",
pages = "373-379",
doi = "10.1016/j.prosdent.2013.07.019"
}

Radović, K., Ilić, J., Roganović, J., Stojić, D., Brković, B.,& Pudar, G.. (2014). Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes. in Journal of Prosthetic Dentistry
Mosby-Elsevier, New York., 111(5), 373-379.
https://doi.org/10.1016/j.prosdent.2013.07.019

Radović K, Ilić J, Roganović J, Stojić D, Brković B, Pudar G. Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes. in Journal of Prosthetic Dentistry. 2014;111(5):373-379.
doi:10.1016/j.prosdent.2013.07.019 .

Radović, Katarina, Ilić, Jugoslav, Roganović, Jelena, Stojić, Dragica, Brković, Božidar, Pudar, Georgina, "Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes" in Journal of Prosthetic Dentistry, 111, no. 5 (2014):373-379,
https://doi.org/10.1016/j.prosdent.2013.07.019 . .

TY  - JOUR
AU  - Brajković, Denis
AU  - Brković, Božidar
AU  - Milić, Marija
AU  - Biočanin, Vladimir
AU  - Kršljak, Elena
AU  - Stojić, Dragica
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1857
AB  - The main purpose of this prospective, double-blind, randomized study was to evaluate anaesthetic parameters, postoperative analgesia and vasoactive properties of levobupivacaine and bupivacaine for lower third molar surgery. Sixty patients (ASA I) were scheduled for lower third molar surgery under inferior alveolar nerve block, lingual nerve block and buccal nerve block (mandibular nerve blocks) obtained with 3 ml of 0.5 % levobupivacaine and 3 ml of 0.5 % bupivacaine. Success rate, onset and duration of three nerve bocks were evaluated by electrical pulp testing, pinprick testing and signs of soft tissue anaesthesia (patient-reported numbness). Intensity of intraoperative anaesthesia and postoperative analgesia were measured with visual analogue scale (VAS) and numeric rating scale (NRS). The time of first postoperative pain reported and analgesic consumption were also recorded. The laser Doppler flowmetry was used for the measurement of the first premolar pulpal blood flow. There were no differences between levobupivacaine and bupivacaine regarding the success rate, onset and duration of mandibular nerve blocks as well as intensity of postoperative analgesia and analgesic consumption. Intensity of intraoperative anaesthesia and duration of postoperative analgesia were significantly higher in the levobupivacaine than in the bupivacaine group. Both anaesthetics showed similar biphasic vasoactive effect. Levobupivacaine 0.5 % achieved superiority over bupivacaine 0.5 % in the intensity of intraoperative anaesthesia and duration of postoperative analgesia for lower third molar surgery under the mandibular nerve blocks. It seems that the plain levobupivacaine (0.5 %) could be an effective alternative to plain bupivacaine (0.5 %) in those dental procedures which require profound bone and soft tissue anaesthesia.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects
VL  - 18
IS  - 5
SP  - 1481
EP  - 1488
DO  - 10.1007/s00784-013-1114-0
ER  - 

@article{
author = "Brajković, Denis and Brković, Božidar and Milić, Marija and Biočanin, Vladimir and Kršljak, Elena and Stojić, Dragica",
year = "2014",
abstract = "The main purpose of this prospective, double-blind, randomized study was to evaluate anaesthetic parameters, postoperative analgesia and vasoactive properties of levobupivacaine and bupivacaine for lower third molar surgery. Sixty patients (ASA I) were scheduled for lower third molar surgery under inferior alveolar nerve block, lingual nerve block and buccal nerve block (mandibular nerve blocks) obtained with 3 ml of 0.5 % levobupivacaine and 3 ml of 0.5 % bupivacaine. Success rate, onset and duration of three nerve bocks were evaluated by electrical pulp testing, pinprick testing and signs of soft tissue anaesthesia (patient-reported numbness). Intensity of intraoperative anaesthesia and postoperative analgesia were measured with visual analogue scale (VAS) and numeric rating scale (NRS). The time of first postoperative pain reported and analgesic consumption were also recorded. The laser Doppler flowmetry was used for the measurement of the first premolar pulpal blood flow. There were no differences between levobupivacaine and bupivacaine regarding the success rate, onset and duration of mandibular nerve blocks as well as intensity of postoperative analgesia and analgesic consumption. Intensity of intraoperative anaesthesia and duration of postoperative analgesia were significantly higher in the levobupivacaine than in the bupivacaine group. Both anaesthetics showed similar biphasic vasoactive effect. Levobupivacaine 0.5 % achieved superiority over bupivacaine 0.5 % in the intensity of intraoperative anaesthesia and duration of postoperative analgesia for lower third molar surgery under the mandibular nerve blocks. It seems that the plain levobupivacaine (0.5 %) could be an effective alternative to plain bupivacaine (0.5 %) in those dental procedures which require profound bone and soft tissue anaesthesia.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects",
volume = "18",
number = "5",
pages = "1481-1488",
doi = "10.1007/s00784-013-1114-0"
}

Brajković, D., Brković, B., Milić, M., Biočanin, V., Kršljak, E.,& Stojić, D.. (2014). Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 18(5), 1481-1488.
https://doi.org/10.1007/s00784-013-1114-0

Brajković D, Brković B, Milić M, Biočanin V, Kršljak E, Stojić D. Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects. in Clinical Oral Investigations. 2014;18(5):1481-1488.
doi:10.1007/s00784-013-1114-0 .

Brajković, Denis, Brković, Božidar, Milić, Marija, Biočanin, Vladimir, Kršljak, Elena, Stojić, Dragica, "Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects" in Clinical Oral Investigations, 18, no. 5 (2014):1481-1488,
https://doi.org/10.1007/s00784-013-1114-0 . .

TY  - JOUR
AU  - Biočanin, Vladimir
AU  - Brković, Božidar
AU  - Miličić, Biljana
AU  - Stojić, Dragica
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1841
AB  - The main purpose of this study was to evaluate the dose-dependent anesthetic efficacy of the intraseptal anesthesia (ISA) and periodontal ligament anesthesia (PLA) obtained with different volumes of 4 % articaine and 1:100,000 epinephrine (Ar + Ep) in human mandibular premolars, using a computer-controlled local anesthetic delivery system (CCLADS). The safety profile of Ar + Ep was also studied by investigating the stability of cardiovascular parameters. One hundred and eighty randomly selected healthy volunteers (ASA I) entered the single-blinded study to receive 16 mg + 4 mu g, 24 mg + 6 mu g, and 32 mg + 8 mu g of Ar + Ep, obtained with different volumes (0.4, 0.6, and 0.8 ml, respectively), for the ISA and PLA. Success rate, onset, and duration of profound pulpal anesthesia were evaluated by the electrical pulp tester, while the width of the anesthetic field and duration of soft tissue anesthesia were recorded using the pinprick testing. A monitor was used for the measurement of cardiovascular parameters. A dose-dependent duration of pulpal and soft tissue anesthesia was obtained only by the ISA. Success rate, duration of both pulpal and soft tissue anesthesia, and its width were significantly better in the ISA compared with the PLA. No significant cardiovascular changes were seen in both groups. It can be suggested that 0.6 and 0.8 ml of 4 % Ar + 1:100,000 Ep, delivered by CCLADS, offer high success rate and effective clinical parameters of ISA as a primary anesthesia. It seems that dental procedures requiring profound pulpal, bone, and soft tissue anesthesia could be effectively and safely obtained by mentioned anesthetic protocol.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine plus epinephrine delivery: a dose-finding study
VL  - 17
IS  - 2
SP  - 525
EP  - 533
DO  - 10.1007/s00784-012-0724-2
ER  - 

@article{
author = "Biočanin, Vladimir and Brković, Božidar and Miličić, Biljana and Stojić, Dragica",
year = "2013",
abstract = "The main purpose of this study was to evaluate the dose-dependent anesthetic efficacy of the intraseptal anesthesia (ISA) and periodontal ligament anesthesia (PLA) obtained with different volumes of 4 % articaine and 1:100,000 epinephrine (Ar + Ep) in human mandibular premolars, using a computer-controlled local anesthetic delivery system (CCLADS). The safety profile of Ar + Ep was also studied by investigating the stability of cardiovascular parameters. One hundred and eighty randomly selected healthy volunteers (ASA I) entered the single-blinded study to receive 16 mg + 4 mu g, 24 mg + 6 mu g, and 32 mg + 8 mu g of Ar + Ep, obtained with different volumes (0.4, 0.6, and 0.8 ml, respectively), for the ISA and PLA. Success rate, onset, and duration of profound pulpal anesthesia were evaluated by the electrical pulp tester, while the width of the anesthetic field and duration of soft tissue anesthesia were recorded using the pinprick testing. A monitor was used for the measurement of cardiovascular parameters. A dose-dependent duration of pulpal and soft tissue anesthesia was obtained only by the ISA. Success rate, duration of both pulpal and soft tissue anesthesia, and its width were significantly better in the ISA compared with the PLA. No significant cardiovascular changes were seen in both groups. It can be suggested that 0.6 and 0.8 ml of 4 % Ar + 1:100,000 Ep, delivered by CCLADS, offer high success rate and effective clinical parameters of ISA as a primary anesthesia. It seems that dental procedures requiring profound pulpal, bone, and soft tissue anesthesia could be effectively and safely obtained by mentioned anesthetic protocol.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine plus epinephrine delivery: a dose-finding study",
volume = "17",
number = "2",
pages = "525-533",
doi = "10.1007/s00784-012-0724-2"
}

Biočanin, V., Brković, B., Miličić, B.,& Stojić, D.. (2013). Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine plus epinephrine delivery: a dose-finding study. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 17(2), 525-533.
https://doi.org/10.1007/s00784-012-0724-2

Biočanin V, Brković B, Miličić B, Stojić D. Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine plus epinephrine delivery: a dose-finding study. in Clinical Oral Investigations. 2013;17(2):525-533.
doi:10.1007/s00784-012-0724-2 .

Biočanin, Vladimir, Brković, Božidar, Miličić, Biljana, Stojić, Dragica, "Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine plus epinephrine delivery: a dose-finding study" in Clinical Oral Investigations, 17, no. 2 (2013):525-533,
https://doi.org/10.1007/s00784-012-0724-2 . .

TY  - JOUR
AU  - Dželetović, Bojan
AU  - Grga, Đurica
AU  - Kršljak, Elena
AU  - Stratimirović, Đorđe
AU  - Brković, Božidar
AU  - Stojić, Dragica
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1760
AB  - Introduction: The skin microcirculation is significantly affected by serum estrogen levels. The objective of this study was to investigate the effects of estrogen serum level changes associated with the menstrual cycle and postmenopause on dental pulp blood flow (PBF) as well as its dynamics. Methods: Young women at the menstrual phase (low serum estrogen levels) and in the mid-cycle phase of the menstrual cycle (high serum estrogen levels) and postmenopausal women were enrolled in the study. PBF and its oscillations were measured by laser Doppler flowmetry and analyzed by using wavelet transform. Serum levels of estradiol-17 beta were measured by immunoassay. Results: PBFs of young women in the menstrual phase and postmenopausal women were mutually similar and significantly lower than those of young women in the mid-cycle period. With respect to the mid-cycle phase, relative amplitude and power were significantly increased in the interval 0.0095-0.02 Hz and decreased in the intervals 0.02-0.06 and 0.06-0.2 Hz in the menstrual phase. A significant decrease in 0.0095-0.02 Hz and increase in 0.02-0.06, 0.06-0.2, 0.2-0.6, and 0.6-1.6 Hz intervals were observed in postmenopause. Conclusions: The study has shown that the menstrual phase of the menstrual cycle and postmenopause have similar PBF decrease, but PBF oscillations are differently affected in the mid-cycle phase. (J Endod 2012;38:1187-1191)
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - Dental Pulp Blood Flow and Its Oscillations in Women with Different Estrogen Status
VL  - 38
IS  - 9
SP  - 1187
EP  - 1191
DO  - 10.1016/j.joen.2012.06.009
ER  - 

@article{
author = "Dželetović, Bojan and Grga, Đurica and Kršljak, Elena and Stratimirović, Đorđe and Brković, Božidar and Stojić, Dragica",
year = "2012",
abstract = "Introduction: The skin microcirculation is significantly affected by serum estrogen levels. The objective of this study was to investigate the effects of estrogen serum level changes associated with the menstrual cycle and postmenopause on dental pulp blood flow (PBF) as well as its dynamics. Methods: Young women at the menstrual phase (low serum estrogen levels) and in the mid-cycle phase of the menstrual cycle (high serum estrogen levels) and postmenopausal women were enrolled in the study. PBF and its oscillations were measured by laser Doppler flowmetry and analyzed by using wavelet transform. Serum levels of estradiol-17 beta were measured by immunoassay. Results: PBFs of young women in the menstrual phase and postmenopausal women were mutually similar and significantly lower than those of young women in the mid-cycle period. With respect to the mid-cycle phase, relative amplitude and power were significantly increased in the interval 0.0095-0.02 Hz and decreased in the intervals 0.02-0.06 and 0.06-0.2 Hz in the menstrual phase. A significant decrease in 0.0095-0.02 Hz and increase in 0.02-0.06, 0.06-0.2, 0.2-0.6, and 0.6-1.6 Hz intervals were observed in postmenopause. Conclusions: The study has shown that the menstrual phase of the menstrual cycle and postmenopause have similar PBF decrease, but PBF oscillations are differently affected in the mid-cycle phase. (J Endod 2012;38:1187-1191)",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "Dental Pulp Blood Flow and Its Oscillations in Women with Different Estrogen Status",
volume = "38",
number = "9",
pages = "1187-1191",
doi = "10.1016/j.joen.2012.06.009"
}

Dželetović, B., Grga, Đ., Kršljak, E., Stratimirović, Đ., Brković, B.,& Stojić, D.. (2012). Dental Pulp Blood Flow and Its Oscillations in Women with Different Estrogen Status. in Journal of Endodontics
Elsevier Science Inc, New York., 38(9), 1187-1191.
https://doi.org/10.1016/j.joen.2012.06.009

Dželetović B, Grga Đ, Kršljak E, Stratimirović Đ, Brković B, Stojić D. Dental Pulp Blood Flow and Its Oscillations in Women with Different Estrogen Status. in Journal of Endodontics. 2012;38(9):1187-1191.
doi:10.1016/j.joen.2012.06.009 .

Dželetović, Bojan, Grga, Đurica, Kršljak, Elena, Stratimirović, Đorđe, Brković, Božidar, Stojić, Dragica, "Dental Pulp Blood Flow and Its Oscillations in Women with Different Estrogen Status" in Journal of Endodontics, 38, no. 9 (2012):1187-1191,
https://doi.org/10.1016/j.joen.2012.06.009 . .

TY  - JOUR
AU  - Ilić, Jugoslav
AU  - Radović, Katarina
AU  - Roganović, Jelena
AU  - Brković, Božidar
AU  - Stojić, Dragica
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1735
AB  - Introduction: Vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP 2) are growth factors (GFs) identified within the dentine-pulp complex and involved into the cellular events connected to the pulp-healing response. It is well established that the expression of these GFs is increased in different tissues in diabetes mellitus. Because there are no data concerning the levels of VEGF and BMP 2 in human dental pulp, the aim of present study was to quantify VEGF and BMP 2 levels in intact dental pulp and dental pulp that underwent reactive dentinogenesis in healthy and diabetic human subjects. Methods: The study was conducted on 28 healthy and 28 subjects with controlled diabetes type II who underwent pulp extirpation as a part of prosthetic rehabilitation. Pulp were collected from intact teeth and teeth treated by indirect pulp capping. The levels of VEGF and BMP 2 were determined in the pulp tissue lysates with enzyme-linked immunosorbent assay. Results: The levels of VEGF and BMP 2 were significantly higher in intact teeth pulp of diabetic than in healthy subjects. The concentrations of these GFs were significantly lowered in teeth with indirect pulp capping both in healthy and diabetic persons. Furthermore, VEGF and BMP 2 levels were in strong positive correlation. Conclusions: Similar changes in the levels of VEGF and BMP 2 in intact and treated teeth of healthy and diabetic patients could be suggestive of associated roles of these GFs in responses of healthy and diabetic dental pulp. (J Endod 2012;38:764-768)
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients
VL  - 38
IS  - 6
SP  - 764
EP  - 768
DO  - 10.1016/j.joen.2012.03.016
ER  - 

@article{
author = "Ilić, Jugoslav and Radović, Katarina and Roganović, Jelena and Brković, Božidar and Stojić, Dragica",
year = "2012",
abstract = "Introduction: Vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP 2) are growth factors (GFs) identified within the dentine-pulp complex and involved into the cellular events connected to the pulp-healing response. It is well established that the expression of these GFs is increased in different tissues in diabetes mellitus. Because there are no data concerning the levels of VEGF and BMP 2 in human dental pulp, the aim of present study was to quantify VEGF and BMP 2 levels in intact dental pulp and dental pulp that underwent reactive dentinogenesis in healthy and diabetic human subjects. Methods: The study was conducted on 28 healthy and 28 subjects with controlled diabetes type II who underwent pulp extirpation as a part of prosthetic rehabilitation. Pulp were collected from intact teeth and teeth treated by indirect pulp capping. The levels of VEGF and BMP 2 were determined in the pulp tissue lysates with enzyme-linked immunosorbent assay. Results: The levels of VEGF and BMP 2 were significantly higher in intact teeth pulp of diabetic than in healthy subjects. The concentrations of these GFs were significantly lowered in teeth with indirect pulp capping both in healthy and diabetic persons. Furthermore, VEGF and BMP 2 levels were in strong positive correlation. Conclusions: Similar changes in the levels of VEGF and BMP 2 in intact and treated teeth of healthy and diabetic patients could be suggestive of associated roles of these GFs in responses of healthy and diabetic dental pulp. (J Endod 2012;38:764-768)",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients",
volume = "38",
number = "6",
pages = "764-768",
doi = "10.1016/j.joen.2012.03.016"
}

Ilić, J., Radović, K., Roganović, J., Brković, B.,& Stojić, D.. (2012). The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients. in Journal of Endodontics
Elsevier Science Inc, New York., 38(6), 764-768.
https://doi.org/10.1016/j.joen.2012.03.016

Ilić J, Radović K, Roganović J, Brković B, Stojić D. The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients. in Journal of Endodontics. 2012;38(6):764-768.
doi:10.1016/j.joen.2012.03.016 .

Ilić, Jugoslav, Radović, Katarina, Roganović, Jelena, Brković, Božidar, Stojić, Dragica, "The Levels of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 in Dental Pulp Tissue of Healthy and Diabetic Patients" in Journal of Endodontics, 38, no. 6 (2012):764-768,
https://doi.org/10.1016/j.joen.2012.03.016 . .

TY  - CHAP
AU  - Stojić, Dragica
AU  - Roganović, Jelena
AU  - Brković, Božidar
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2593
AB  - Branches of the external carotid artery support the integrity and functionality of oral tissue beds with critical impact in both health and disease. Stenosis or occlusion of the common carotid artery or of the tributaries – facial, maxillary, lingual arteries and dental pulp arterioles – contribute to the etiology of disease, in particular in the setting of ischemic and metabolic syndrome disorders of orofacial tissues.
Blood flow through salivary glands is largely controlled via autonomic innervation, and endothelium-derived vasodilating and vasoconstricting substances. Endothelial cells actively regulate basal vascular tone and vascular reactivity in physiological and pathological conditions. In the resting state, blood flow in rat submandibular gland is largely controlled by sympathetic nerves, but vascular resistance is rapidly lowered by parasympathetic activity. Increase in blood flow during parasympathetic stimulation, through co-release of the neurotransmitters Ach and VIP, has been attributed to the release of endothelium-derived NO, prostacyclin and EDHF. In the glandular branch of rabbit facial artery, Ach provokes endothelium-dependent vasorelaxation, mediated by NO and prostacyclin, while VIP induces an endothelium-independent vasorelaxant effect, mediated by cAMP from vascular smooth muscle and neuronal NO. In the human submandibular artery, both transmitters produce endothelium-dependent vasodilation with different mechanisms, release of NO and prostacyclin for Ach and release of NO and EDHF for VIP.
Endothelial dysfunction is commonly attributed to impaired endothelium-dependent vasorelaxation and increased vascular tone. In diabetic rat salivary glands, parasympathetic stimulation causes increased blood flow with delayed initial response. Carotid artery occlusion decreases the responsiveness of the glandular branch of the rabbit facial artery to Ach and VIP, with altered endothelial, smooth muscle and neuronal signaling.
The dental pulp is a highly vascularized tissue, richly supplied with vasomotor nerves of sensory and sympathetic origin. A major difference between the vascularization of the pulp versus other tissues is the low-compliance since in the pulp vasodilation might lead to necrosis due to secondary vasoconstriction, whereas vasodilation typically in other tissues promotes survival during inflammation. Catecholamines are an important element in neuronal and humoral regulation of pulpal blood flow. Administration of catecholamines with local anesthetics causes sufficient vasoconstriction to disturb the pulpal microcirculation in dental patients. Endothelial NOS was detected in endothelium of the rat pulp microvasculature and it is likely that NO regulates pulpal vasodilation through a cGMP-dependent mechanism. NO synthesized from nerve fibers and odontoblasts could also reach endothelial and vascular smooth muscle cells of the pulp to regulate blood vessel function.
In contrast to vasoconstriction of pulpal blood vessels, vasoconstriction of maxillary artery branches is useful for effective and long intraoral anesthesia. Local anesthetics are vasodilators, leading to decreased anesthetic effect, except ropivacaine which exert vasoconstriction on isolated infraorbital branches of human maxillary artery. To oppose the vasodilatory action of local anesthetics epinephrine is added to local anesthetic solutions. However, because of its absorption from injection sites, there are some limitations in the cardiovascularly compromised patients. It has been shown that clonidine, an alpha 2 adrenergic agonist, is a safer vasoconstrictor than epinephrine, providing hemodynamic stability due to its central hypotensive action.
PB  - Nova Science Publishers, Inc.
T2  - Advances in Medicine and Biology. Volume 29
T1  - Functionality of Orofacial Branches Feeding: Salivary Glands, Dental Pulp and Intraoral Anesthetic Field
SP  - 59
EP  - 95
UR  - https://hdl.handle.net/21.15107/rcub_smile_2593
ER  - 

@inbook{
author = "Stojić, Dragica and Roganović, Jelena and Brković, Božidar",
year = "2012",
abstract = "Branches of the external carotid artery support the integrity and functionality of oral tissue beds with critical impact in both health and disease. Stenosis or occlusion of the common carotid artery or of the tributaries – facial, maxillary, lingual arteries and dental pulp arterioles – contribute to the etiology of disease, in particular in the setting of ischemic and metabolic syndrome disorders of orofacial tissues.
Blood flow through salivary glands is largely controlled via autonomic innervation, and endothelium-derived vasodilating and vasoconstricting substances. Endothelial cells actively regulate basal vascular tone and vascular reactivity in physiological and pathological conditions. In the resting state, blood flow in rat submandibular gland is largely controlled by sympathetic nerves, but vascular resistance is rapidly lowered by parasympathetic activity. Increase in blood flow during parasympathetic stimulation, through co-release of the neurotransmitters Ach and VIP, has been attributed to the release of endothelium-derived NO, prostacyclin and EDHF. In the glandular branch of rabbit facial artery, Ach provokes endothelium-dependent vasorelaxation, mediated by NO and prostacyclin, while VIP induces an endothelium-independent vasorelaxant effect, mediated by cAMP from vascular smooth muscle and neuronal NO. In the human submandibular artery, both transmitters produce endothelium-dependent vasodilation with different mechanisms, release of NO and prostacyclin for Ach and release of NO and EDHF for VIP.
Endothelial dysfunction is commonly attributed to impaired endothelium-dependent vasorelaxation and increased vascular tone. In diabetic rat salivary glands, parasympathetic stimulation causes increased blood flow with delayed initial response. Carotid artery occlusion decreases the responsiveness of the glandular branch of the rabbit facial artery to Ach and VIP, with altered endothelial, smooth muscle and neuronal signaling.
The dental pulp is a highly vascularized tissue, richly supplied with vasomotor nerves of sensory and sympathetic origin. A major difference between the vascularization of the pulp versus other tissues is the low-compliance since in the pulp vasodilation might lead to necrosis due to secondary vasoconstriction, whereas vasodilation typically in other tissues promotes survival during inflammation. Catecholamines are an important element in neuronal and humoral regulation of pulpal blood flow. Administration of catecholamines with local anesthetics causes sufficient vasoconstriction to disturb the pulpal microcirculation in dental patients. Endothelial NOS was detected in endothelium of the rat pulp microvasculature and it is likely that NO regulates pulpal vasodilation through a cGMP-dependent mechanism. NO synthesized from nerve fibers and odontoblasts could also reach endothelial and vascular smooth muscle cells of the pulp to regulate blood vessel function.
In contrast to vasoconstriction of pulpal blood vessels, vasoconstriction of maxillary artery branches is useful for effective and long intraoral anesthesia. Local anesthetics are vasodilators, leading to decreased anesthetic effect, except ropivacaine which exert vasoconstriction on isolated infraorbital branches of human maxillary artery. To oppose the vasodilatory action of local anesthetics epinephrine is added to local anesthetic solutions. However, because of its absorption from injection sites, there are some limitations in the cardiovascularly compromised patients. It has been shown that clonidine, an alpha 2 adrenergic agonist, is a safer vasoconstrictor than epinephrine, providing hemodynamic stability due to its central hypotensive action.",
publisher = "Nova Science Publishers, Inc.",
journal = "Advances in Medicine and Biology. Volume 29",
booktitle = "Functionality of Orofacial Branches Feeding: Salivary Glands, Dental Pulp and Intraoral Anesthetic Field",
pages = "59-95",
url = "https://hdl.handle.net/21.15107/rcub_smile_2593"
}

Stojić, D., Roganović, J.,& Brković, B.. (2012). Functionality of Orofacial Branches Feeding: Salivary Glands, Dental Pulp and Intraoral Anesthetic Field. in Advances in Medicine and Biology. Volume 29
Nova Science Publishers, Inc.., 59-95.
https://hdl.handle.net/21.15107/rcub_smile_2593

Stojić D, Roganović J, Brković B. Functionality of Orofacial Branches Feeding: Salivary Glands, Dental Pulp and Intraoral Anesthetic Field. in Advances in Medicine and Biology. Volume 29. 2012;:59-95.
https://hdl.handle.net/21.15107/rcub_smile_2593 .

Stojić, Dragica, Roganović, Jelena, Brković, Božidar, "Functionality of Orofacial Branches Feeding: Salivary Glands, Dental Pulp and Intraoral Anesthetic Field" in Advances in Medicine and Biology. Volume 29 (2012):59-95,
https://hdl.handle.net/21.15107/rcub_smile_2593 .

TY  - JOUR
AU  - Biočanin, Vladimir
AU  - Milić, Marija
AU  - Brajković, Denis
AU  - Brković, Božidar
AU  - Stojić, Dragica
AU  - Todorović, Ljubomir
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1660
AB  - Objective. The aim of this study was to investigate quality and safety of supplemental intraoral anesthesia - periodontal ligament anaesthesia (PDL) and intraseptal anaesthesia (ISA) after computer-controlled articaine delivery. Method. 54 ASA I volunteers randomly divided into 2 groups participated in this study. 0.4 ml of 4% articaine with 1:100.000 epinephrine were randomly administered with computer-controlled local anaesthetic delivery system on the mesial and distal side of maxillary lateral incisor for ISA or PDL. An electric pulp tester was used to test the pulpal anaesthesia, in 2-minute cycles for 60 minutes. Anaesthesia was considered successful when 2 or more consecutive no-response at 80 readings were obtained. Soft-tissue anaesthesia was measured by pin-prick test. Results. Success rates for ISA and PDL were 77.8% and 55.6% respectively, but difference was not statistically significant (p>0.05). Duration of complete pulpal anaesthesia was significantly longer (p lt 0.05) with the ISA in comparison to the PDL. The width of anesthetizied field was significantly greater (p lt 0.05) with the ISA than with the PDL, both for attached gingiva and oral mucosa. No side effects were recorded during the study. Conclusion. The results of this study indicate that the ISA technique is successful in obtaining complete pulpal anaesthesia of upper lateral incisors and soft-tissue anaesthesia in this area.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Stomatology
T1  - Efficacy of computer-controlled articaine delivery for supplemental intraoral anaesthesia
VL  - 15
IS  - 1
SP  - 11
EP  - 14
UR  - https://hdl.handle.net/21.15107/rcub_smile_1660
ER  - 

@article{
author = "Biočanin, Vladimir and Milić, Marija and Brajković, Denis and Brković, Božidar and Stojić, Dragica and Todorović, Ljubomir",
year = "2011",
abstract = "Objective. The aim of this study was to investigate quality and safety of supplemental intraoral anesthesia - periodontal ligament anaesthesia (PDL) and intraseptal anaesthesia (ISA) after computer-controlled articaine delivery. Method. 54 ASA I volunteers randomly divided into 2 groups participated in this study. 0.4 ml of 4% articaine with 1:100.000 epinephrine were randomly administered with computer-controlled local anaesthetic delivery system on the mesial and distal side of maxillary lateral incisor for ISA or PDL. An electric pulp tester was used to test the pulpal anaesthesia, in 2-minute cycles for 60 minutes. Anaesthesia was considered successful when 2 or more consecutive no-response at 80 readings were obtained. Soft-tissue anaesthesia was measured by pin-prick test. Results. Success rates for ISA and PDL were 77.8% and 55.6% respectively, but difference was not statistically significant (p>0.05). Duration of complete pulpal anaesthesia was significantly longer (p lt 0.05) with the ISA in comparison to the PDL. The width of anesthetizied field was significantly greater (p lt 0.05) with the ISA than with the PDL, both for attached gingiva and oral mucosa. No side effects were recorded during the study. Conclusion. The results of this study indicate that the ISA technique is successful in obtaining complete pulpal anaesthesia of upper lateral incisors and soft-tissue anaesthesia in this area.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Stomatology",
title = "Efficacy of computer-controlled articaine delivery for supplemental intraoral anaesthesia",
volume = "15",
number = "1",
pages = "11-14",
url = "https://hdl.handle.net/21.15107/rcub_smile_1660"
}

Biočanin, V., Milić, M., Brajković, D., Brković, B., Stojić, D.,& Todorović, L.. (2011). Efficacy of computer-controlled articaine delivery for supplemental intraoral anaesthesia. in Balkan Journal of Stomatology
Udruženje stomatologa Balkana., 15(1), 11-14.
https://hdl.handle.net/21.15107/rcub_smile_1660

Biočanin V, Milić M, Brajković D, Brković B, Stojić D, Todorović L. Efficacy of computer-controlled articaine delivery for supplemental intraoral anaesthesia. in Balkan Journal of Stomatology. 2011;15(1):11-14.
https://hdl.handle.net/21.15107/rcub_smile_1660 .

Biočanin, Vladimir, Milić, Marija, Brajković, Denis, Brković, Božidar, Stojić, Dragica, Todorović, Ljubomir, "Efficacy of computer-controlled articaine delivery for supplemental intraoral anaesthesia" in Balkan Journal of Stomatology, 15, no. 1 (2011):11-14,
https://hdl.handle.net/21.15107/rcub_smile_1660 .

TY  - JOUR
AU  - Roganović, Jelena
AU  - Radenković, Miroslav
AU  - Tanić, Nikola
AU  - Tanić, Nasta
AU  - Petrović, Nina
AU  - Stojić, Dragica
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1625
AB  - The aim of this study was to assess the effect of type 1 diabetes mellitus (induced by a single intravenous injection of 100 mg kg(-1) of alloxan) on acetylcholine (ACh)-induced relaxation in isolated rabbit parotid gland feeding artery. Isometric force measurements and quantification of inducible nitric oxide synthase (iNOS) mRNA by real-time RT-PCR were made in parotid artery rings from diabetic and control rabbits. Acetylcholine induced concentration- and endothelium-dependent vasorelaxation that was significantly decreased in parotid artery rings from diabetic rabbits. Schild analysis of the ACh vasorelaxant effect, in the presence of selective muscarinic receptor antagonists, revealed involvement of the M-3 receptor subtype in parotid artery rings from both control and diabetic rabbits, with no change in antagonist affinity constants. The inhibitory effects of indomethacin, a non-selective inhibitor of cyclooxygenase, and of high potassium, an inhibitor of hyperpolarization, on ACh vasorelaxation were increased. The effect of N-G-nitro-L-arginine, a non-selective inhibitor of NOS, was decreased in diabetes. S-methylisothiourea, a selective inhibitor of iNOS, significantly reduced ACh vasorelaxation only in parotid artery rings from diabetic rabbits. Also, up-regulation of iNOS mRNA expression was detected in parotid artery rings from diabetic rabbits. These results suggest that in parotid artery rings from diabetic rabbits, impaired endothelium-dependent vasorelaxation to ACh appears to be caused by the loss of a nitric oxide-mediated component and increased iNOS expression, and is unlikely to be caused by a change at the M-3 receptor level.
PB  - Wiley, Hoboken
T2  - European Journal of Oral Sciences
T1  - Impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated parotid artery of the alloxan-induced diabetic rabbit
VL  - 119
IS  - 5
SP  - 352
EP  - 360
DO  - 10.1111/j.1600-0722.2011.00851.x
ER  - 

@article{
author = "Roganović, Jelena and Radenković, Miroslav and Tanić, Nikola and Tanić, Nasta and Petrović, Nina and Stojić, Dragica",
year = "2011",
abstract = "The aim of this study was to assess the effect of type 1 diabetes mellitus (induced by a single intravenous injection of 100 mg kg(-1) of alloxan) on acetylcholine (ACh)-induced relaxation in isolated rabbit parotid gland feeding artery. Isometric force measurements and quantification of inducible nitric oxide synthase (iNOS) mRNA by real-time RT-PCR were made in parotid artery rings from diabetic and control rabbits. Acetylcholine induced concentration- and endothelium-dependent vasorelaxation that was significantly decreased in parotid artery rings from diabetic rabbits. Schild analysis of the ACh vasorelaxant effect, in the presence of selective muscarinic receptor antagonists, revealed involvement of the M-3 receptor subtype in parotid artery rings from both control and diabetic rabbits, with no change in antagonist affinity constants. The inhibitory effects of indomethacin, a non-selective inhibitor of cyclooxygenase, and of high potassium, an inhibitor of hyperpolarization, on ACh vasorelaxation were increased. The effect of N-G-nitro-L-arginine, a non-selective inhibitor of NOS, was decreased in diabetes. S-methylisothiourea, a selective inhibitor of iNOS, significantly reduced ACh vasorelaxation only in parotid artery rings from diabetic rabbits. Also, up-regulation of iNOS mRNA expression was detected in parotid artery rings from diabetic rabbits. These results suggest that in parotid artery rings from diabetic rabbits, impaired endothelium-dependent vasorelaxation to ACh appears to be caused by the loss of a nitric oxide-mediated component and increased iNOS expression, and is unlikely to be caused by a change at the M-3 receptor level.",
publisher = "Wiley, Hoboken",
journal = "European Journal of Oral Sciences",
title = "Impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated parotid artery of the alloxan-induced diabetic rabbit",
volume = "119",
number = "5",
pages = "352-360",
doi = "10.1111/j.1600-0722.2011.00851.x"
}

Roganović, J., Radenković, M., Tanić, N., Tanić, N., Petrović, N.,& Stojić, D.. (2011). Impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated parotid artery of the alloxan-induced diabetic rabbit. in European Journal of Oral Sciences
Wiley, Hoboken., 119(5), 352-360.
https://doi.org/10.1111/j.1600-0722.2011.00851.x

Roganović J, Radenković M, Tanić N, Tanić N, Petrović N, Stojić D. Impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated parotid artery of the alloxan-induced diabetic rabbit. in European Journal of Oral Sciences. 2011;119(5):352-360.
doi:10.1111/j.1600-0722.2011.00851.x .

Roganović, Jelena, Radenković, Miroslav, Tanić, Nikola, Tanić, Nasta, Petrović, Nina, Stojić, Dragica, "Impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated parotid artery of the alloxan-induced diabetic rabbit" in European Journal of Oral Sciences, 119, no. 5 (2011):352-360,
https://doi.org/10.1111/j.1600-0722.2011.00851.x . .

TY  - JOUR
AU  - Roganović, Jelena
AU  - Radenković, Miroslav
AU  - Stojić, Dragica
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1592
AB  - Objectives: The influence of carotid artery occlusion (10, 30 and 60 min) on regulatory mechanisms implicated in the vasorelaxant responses of isolated glandular branch of rabbit facial artery to acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) was examined. Design: In organ bath studies with arterial rings precontracted with phenylephrine (1 mu M), before and after carotid artery occlusion, changes in isometric tension were recorded. Results: Endothelium-dependent vasorelaxation by ACh and endothelium-independent vasorelaxation by VIP were significantly reduced, started from 30 and 10 mm of carotid occlusion, respectively. Inhibitory effect of indomethacin on ACh vasorelaxation was enhanced whilst effect of N-G-nitro-L-arginine reduced, started from 30 min of carotid occlusion. Sodium nitroprusside-induced vasorelaxation was not changed after carotid occlusion. Inhibition of VIP vasorelaxation by L-N-omega-nitroarginine-2,4-L-diaminobutyric-amide, was reduced, started from 30 min of carotid occlusion. Forskolin enhanced VIP-induced vasorelaxation in control rings but this effect was reduced started from 30 min of occlusion. In the presence of VIP, vasorelaxant effect of ACh was increased; the increase was reduced, started from 10 min of carotid occlusion. Conclusions: The present investigation provides evidence for the decreased responsiveness to both, ACh-endothelium-dependent and VIP-endothelium-independent vasorelaxation in rabbit facial artery after carotid occlusion. In addition, the data suggest that ischaemia alters contribution of endothelial nitric oxide (eNO) and prostaglandin to ACh, and vascular smooth muscle's cAMP and neuronal NO to VIP vasorelaxant effects.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Archives of Oral Biology
T1  - ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion
VL  - 55
IS  - 5
SP  - 333
EP  - 342
DO  - 10.1016/j.archoralbio.2010.03.006
ER  - 

@article{
author = "Roganović, Jelena and Radenković, Miroslav and Stojić, Dragica",
year = "2010",
abstract = "Objectives: The influence of carotid artery occlusion (10, 30 and 60 min) on regulatory mechanisms implicated in the vasorelaxant responses of isolated glandular branch of rabbit facial artery to acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) was examined. Design: In organ bath studies with arterial rings precontracted with phenylephrine (1 mu M), before and after carotid artery occlusion, changes in isometric tension were recorded. Results: Endothelium-dependent vasorelaxation by ACh and endothelium-independent vasorelaxation by VIP were significantly reduced, started from 30 and 10 mm of carotid occlusion, respectively. Inhibitory effect of indomethacin on ACh vasorelaxation was enhanced whilst effect of N-G-nitro-L-arginine reduced, started from 30 min of carotid occlusion. Sodium nitroprusside-induced vasorelaxation was not changed after carotid occlusion. Inhibition of VIP vasorelaxation by L-N-omega-nitroarginine-2,4-L-diaminobutyric-amide, was reduced, started from 30 min of carotid occlusion. Forskolin enhanced VIP-induced vasorelaxation in control rings but this effect was reduced started from 30 min of occlusion. In the presence of VIP, vasorelaxant effect of ACh was increased; the increase was reduced, started from 10 min of carotid occlusion. Conclusions: The present investigation provides evidence for the decreased responsiveness to both, ACh-endothelium-dependent and VIP-endothelium-independent vasorelaxation in rabbit facial artery after carotid occlusion. In addition, the data suggest that ischaemia alters contribution of endothelial nitric oxide (eNO) and prostaglandin to ACh, and vascular smooth muscle's cAMP and neuronal NO to VIP vasorelaxant effects.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Archives of Oral Biology",
title = "ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion",
volume = "55",
number = "5",
pages = "333-342",
doi = "10.1016/j.archoralbio.2010.03.006"
}

Roganović, J., Radenković, M.,& Stojić, D.. (2010). ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion. in Archives of Oral Biology
Pergamon-Elsevier Science Ltd, Oxford., 55(5), 333-342.
https://doi.org/10.1016/j.archoralbio.2010.03.006

Roganović J, Radenković M, Stojić D. ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion. in Archives of Oral Biology. 2010;55(5):333-342.
doi:10.1016/j.archoralbio.2010.03.006 .

Roganović, Jelena, Radenković, Miroslav, Stojić, Dragica, "ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion" in Archives of Oral Biology, 55, no. 5 (2010):333-342,
https://doi.org/10.1016/j.archoralbio.2010.03.006 . .

TY  - JOUR
AU  - Brković, Božidar
AU  - Zlatković, M.
AU  - Jovanović, D.
AU  - Stojić, Dragica
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1530
AB  - The main purpose of this Study was to assess the clinical efficacy and haemodynamic effects of ropivacaine for infiltration anaesthesia in patients undergoing surgical removal of upper third molars. The safety profile of ropivacaine was also Studied by investigating the maximal venous plasma concentration of ropivacaine and the reactivity to ropivacaine of isolated human infraorbital arteries. Ropivacaine in concentrations of 0.5, 0.75 and 1% achieved dose-dependent parameters of maxillary infiltration aneasthesia, clinically relevant in concentrations 0.75 and 1%. Postoperative needs for analgesics were observed in 67-100% of patients. Haemodynamic parameters were stable during surgery with significant changes occuring 10 min after surgery. After maxillary infiltration of 2.0 ml 1% ropivacaine, the maximum venous plasma concentration Cmax) was 82 +/- 15 mg/l. On isolated human infraorbital artery, ropivacaine (10(-4) M) induced endothelium-independent contraction. This study suggests that 0.75 and 1% ropivacaine offers adequate and safe intraoperative analgesia but not Successful postoperative pain control for the surgical removal Of upper third molars.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery
VL  - 39
IS  - 1
SP  - 36
EP  - 41
DO  - 10.1016/j.ijom.2009.11.009
ER  - 

@article{
author = "Brković, Božidar and Zlatković, M. and Jovanović, D. and Stojić, Dragica",
year = "2010",
abstract = "The main purpose of this Study was to assess the clinical efficacy and haemodynamic effects of ropivacaine for infiltration anaesthesia in patients undergoing surgical removal of upper third molars. The safety profile of ropivacaine was also Studied by investigating the maximal venous plasma concentration of ropivacaine and the reactivity to ropivacaine of isolated human infraorbital arteries. Ropivacaine in concentrations of 0.5, 0.75 and 1% achieved dose-dependent parameters of maxillary infiltration aneasthesia, clinically relevant in concentrations 0.75 and 1%. Postoperative needs for analgesics were observed in 67-100% of patients. Haemodynamic parameters were stable during surgery with significant changes occuring 10 min after surgery. After maxillary infiltration of 2.0 ml 1% ropivacaine, the maximum venous plasma concentration Cmax) was 82 +/- 15 mg/l. On isolated human infraorbital artery, ropivacaine (10(-4) M) induced endothelium-independent contraction. This study suggests that 0.75 and 1% ropivacaine offers adequate and safe intraoperative analgesia but not Successful postoperative pain control for the surgical removal Of upper third molars.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery",
volume = "39",
number = "1",
pages = "36-41",
doi = "10.1016/j.ijom.2009.11.009"
}

Brković, B., Zlatković, M., Jovanović, D.,& Stojić, D.. (2010). Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 39(1), 36-41.
https://doi.org/10.1016/j.ijom.2009.11.009

Brković B, Zlatković M, Jovanović D, Stojić D. Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery. in International Journal of Oral & Maxillofacial Surgery. 2010;39(1):36-41.
doi:10.1016/j.ijom.2009.11.009 .

Brković, Božidar, Zlatković, M., Jovanović, D., Stojić, Dragica, "Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery" in International Journal of Oral & Maxillofacial Surgery, 39, no. 1 (2010):36-41,
https://doi.org/10.1016/j.ijom.2009.11.009 . .

TY  - JOUR
AU  - Brković, Božidar
AU  - Stojić, Dragica
AU  - Čolić, Snježana
AU  - Milenković, Ana
AU  - Todorović, Ljubomir
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1418
AB  - Introduction: Since there is no data concerning local analgesic efficacy of ropivacaine for lower third molar surgery, the aim of this doubleblind study was to compare local anaesthetic parameters and postoperative analgesic requirements after the use of ropivacaine and bupivacaine for the inferior alveolar nerve block. Materials and Method: 20 healthy patients were equally randomized into the ropivacaine (0.75%, 2 ml) or bupivacaine (0.5%, 2 ml) groups. The onset and duration of anaesthesia (the lower lip numbness and pinprick test) and intensity of anaesthesia (visual analogue and verbal rating scales) were determined. The postoperative pain reports and analgesic requirements were also recorded. Results: There were no significant differences concerning parameters of the achieved anaesthesia. 2 patients in the bupivacaine group felt postoperative pain without the need for pain medication. Conclusion: Ropivacaine is suitable for achieving local anaesthesia in lower third molar surgery, especially when prolonged analgesia is desired.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Stomatology
T1  - Analgesic efficacy of 0.75% ropivacaine for lower third molar surgery
VL  - 12
IS  - 1
SP  - 31
EP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_smile_1418
ER  - 

@article{
author = "Brković, Božidar and Stojić, Dragica and Čolić, Snježana and Milenković, Ana and Todorović, Ljubomir",
year = "2008",
abstract = "Introduction: Since there is no data concerning local analgesic efficacy of ropivacaine for lower third molar surgery, the aim of this doubleblind study was to compare local anaesthetic parameters and postoperative analgesic requirements after the use of ropivacaine and bupivacaine for the inferior alveolar nerve block. Materials and Method: 20 healthy patients were equally randomized into the ropivacaine (0.75%, 2 ml) or bupivacaine (0.5%, 2 ml) groups. The onset and duration of anaesthesia (the lower lip numbness and pinprick test) and intensity of anaesthesia (visual analogue and verbal rating scales) were determined. The postoperative pain reports and analgesic requirements were also recorded. Results: There were no significant differences concerning parameters of the achieved anaesthesia. 2 patients in the bupivacaine group felt postoperative pain without the need for pain medication. Conclusion: Ropivacaine is suitable for achieving local anaesthesia in lower third molar surgery, especially when prolonged analgesia is desired.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Stomatology",
title = "Analgesic efficacy of 0.75% ropivacaine for lower third molar surgery",
volume = "12",
number = "1",
pages = "31-33",
url = "https://hdl.handle.net/21.15107/rcub_smile_1418"
}

Brković, B., Stojić, D., Čolić, S., Milenković, A.,& Todorović, L.. (2008). Analgesic efficacy of 0.75% ropivacaine for lower third molar surgery. in Balkan Journal of Stomatology
Udruženje stomatologa Balkana., 12(1), 31-33.
https://hdl.handle.net/21.15107/rcub_smile_1418

Brković B, Stojić D, Čolić S, Milenković A, Todorović L. Analgesic efficacy of 0.75% ropivacaine for lower third molar surgery. in Balkan Journal of Stomatology. 2008;12(1):31-33.
https://hdl.handle.net/21.15107/rcub_smile_1418 .

Brković, Božidar, Stojić, Dragica, Čolić, Snježana, Milenković, Ana, Todorović, Ljubomir, "Analgesic efficacy of 0.75% ropivacaine for lower third molar surgery" in Balkan Journal of Stomatology, 12, no. 1 (2008):31-33,
https://hdl.handle.net/21.15107/rcub_smile_1418 .

TY  - JOUR
AU  - Brković, Božidar
AU  - Gardašević, Milka
AU  - Roganović, Jelena
AU  - Jović, N.
AU  - Todorović, L.
AU  - Stojić, Dragica
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1426
AB  - The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 mu g/ml; n = 20) or epinephrine (12.5 mu g/ml; n = 20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine + clonidine were similar to those obtained with lidocaine + epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine + clonidine group and significant increase in heart rate in the lidocaine + epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) and 10(-5) M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine + clonidine combination could be a useful and safe alternative to lidocaine + epinephrine for intraoral infiltration anaesthesia.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects
VL  - 37
IS  - 2
SP  - 149
EP  - 155
DO  - 10.1016/j.ijom.2007.07.019
ER  - 

@article{
author = "Brković, Božidar and Gardašević, Milka and Roganović, Jelena and Jović, N. and Todorović, L. and Stojić, Dragica",
year = "2008",
abstract = "The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 mu g/ml; n = 20) or epinephrine (12.5 mu g/ml; n = 20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine + clonidine were similar to those obtained with lidocaine + epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine + clonidine group and significant increase in heart rate in the lidocaine + epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) and 10(-5) M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine + clonidine combination could be a useful and safe alternative to lidocaine + epinephrine for intraoral infiltration anaesthesia.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects",
volume = "37",
number = "2",
pages = "149-155",
doi = "10.1016/j.ijom.2007.07.019"
}

Brković, B., Gardašević, M., Roganović, J., Jović, N., Todorović, L.,& Stojić, D.. (2008). Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 37(2), 149-155.
https://doi.org/10.1016/j.ijom.2007.07.019

Brković B, Gardašević M, Roganović J, Jović N, Todorović L, Stojić D. Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. in International Journal of Oral & Maxillofacial Surgery. 2008;37(2):149-155.
doi:10.1016/j.ijom.2007.07.019 .

Brković, Božidar, Gardašević, Milka, Roganović, Jelena, Jović, N., Todorović, L., Stojić, Dragica, "Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects" in International Journal of Oral & Maxillofacial Surgery, 37, no. 2 (2008):149-155,
https://doi.org/10.1016/j.ijom.2007.07.019 . .

TY  - JOUR
AU  - Pešić, Srđan
AU  - Radenković, Miroslav
AU  - Popović-Roganović, Jelena
AU  - Pešić, Zoran
AU  - Grbović, Leosava
AU  - Stojić, Dragica
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2589
AB  - Endothelial vasodilatory substances may play a central role in the local regulation of vascular tone. We hypothesized that these substances can mediate endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery. We evaluated the contributions of endothelial vasodilatory substances to vessel relaxation in response to ACh and VIP, using different inhibitors of endothelial vasodilation, the nitric oxide synthase inhibitor, the cyclo-oxygenase inhibitor, indomethacin, the potassium channel blocker, and 4-aminopyridine. ACh and VIP caused an endothelium- and concentration-dependent relaxation in this artery. ACh relaxation was completely blocked after the concomitant addition of N(G)-nitro-L-arginine and indomethacin. The vasorelaxant effect of ACh was not influenced by 4-aminopyridine. VIP relaxation was almost completely abolished by 4-aminopyridine, and was partly inhibited by N(G)-nitro-L-arginine, but was not affected by indomethacin. Thus, in the human submandibular artery, ACh and VIP produced endothelium-dependent vasodilation with different underlying mechanisms: release of nitric oxide (NO) and cyclo-oxygenase products for ACh, and release of NO and endothelium-derived hyperpolarizing factor for VIP.
PB  - Sage Publications Inc.
T2  - Journal of Dental Research
T1  - Responses of the human submandibular artery to ACh and VIP
VL  - 86
IS  - 6
SP  - 565
EP  - 570
DO  - 10.1177/154405910708600615
ER  - 

@article{
author = "Pešić, Srđan and Radenković, Miroslav and Popović-Roganović, Jelena and Pešić, Zoran and Grbović, Leosava and Stojić, Dragica",
year = "2007",
abstract = "Endothelial vasodilatory substances may play a central role in the local regulation of vascular tone. We hypothesized that these substances can mediate endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery. We evaluated the contributions of endothelial vasodilatory substances to vessel relaxation in response to ACh and VIP, using different inhibitors of endothelial vasodilation, the nitric oxide synthase inhibitor, the cyclo-oxygenase inhibitor, indomethacin, the potassium channel blocker, and 4-aminopyridine. ACh and VIP caused an endothelium- and concentration-dependent relaxation in this artery. ACh relaxation was completely blocked after the concomitant addition of N(G)-nitro-L-arginine and indomethacin. The vasorelaxant effect of ACh was not influenced by 4-aminopyridine. VIP relaxation was almost completely abolished by 4-aminopyridine, and was partly inhibited by N(G)-nitro-L-arginine, but was not affected by indomethacin. Thus, in the human submandibular artery, ACh and VIP produced endothelium-dependent vasodilation with different underlying mechanisms: release of nitric oxide (NO) and cyclo-oxygenase products for ACh, and release of NO and endothelium-derived hyperpolarizing factor for VIP.",
publisher = "Sage Publications Inc.",
journal = "Journal of Dental Research",
title = "Responses of the human submandibular artery to ACh and VIP",
volume = "86",
number = "6",
pages = "565-570",
doi = "10.1177/154405910708600615"
}

Pešić, S., Radenković, M., Popović-Roganović, J., Pešić, Z., Grbović, L.,& Stojić, D.. (2007). Responses of the human submandibular artery to ACh and VIP. in Journal of Dental Research
Sage Publications Inc.., 86(6), 565-570.
https://doi.org/10.1177/154405910708600615

Pešić S, Radenković M, Popović-Roganović J, Pešić Z, Grbović L, Stojić D. Responses of the human submandibular artery to ACh and VIP. in Journal of Dental Research. 2007;86(6):565-570.
doi:10.1177/154405910708600615 .

Pešić, Srđan, Radenković, Miroslav, Popović-Roganović, Jelena, Pešić, Zoran, Grbović, Leosava, Stojić, Dragica, "Responses of the human submandibular artery to ACh and VIP" in Journal of Dental Research, 86, no. 6 (2007):565-570,
https://doi.org/10.1177/154405910708600615 . .

TY  - JOUR
AU  - Popović, Jelena
AU  - Kršljak, Elena
AU  - Grbović, Leposava
AU  - Stojić, Dragica
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2591
AB  - Objective: Acute and chronic actions of lithium on salivation induced by agonists associated with receptor-linked hydrolysis of membrane inositol phospholipids (carbachol and phenylephrine) and by agonist linked to activation of adenylate cyclase (isoproterenol) were investigated. 
Material and methods: In anaesthetized rats, submandibular salivation induced by intravenous injection of carbachol, phenylephrine and isoproterenol, was measured and expressed as volume of fluid (microl) elicited per 100 mg wet weight of each gland per minute. The experiments were repeated after acute and chronic treatment of lithium (7 mg kg(-1)). The results were analysed with unpaired t-test. 
Results: Chronic, but not acute lithium treatment significantly decreases carbachol- and phenylephrine-induced salivation while isoproterenol-induced salivation was not changed neither after acute nor after chronic administration of lithium. 
Conclusion: The results suggest that hyposalivation during chronic lithium therapy could be mediated by alterations in the phosphatidylinositol cycle and a consequent lack of inositol after agonist stimulation.
PB  - John Wiley & Sons, Inc.
PB  - Blackwell Munksgaard
T2  - Oral Diseases
T1  - The effects of acute and chronic lithium treatment on rat submandibular salivation
VL  - 11
IS  - 2
SP  - 100
EP  - 103
DO  - 10.1111/j.1601-0825.2004.01066.x
ER  - 

@article{
author = "Popović, Jelena and Kršljak, Elena and Grbović, Leposava and Stojić, Dragica",
year = "2005",
abstract = "Objective: Acute and chronic actions of lithium on salivation induced by agonists associated with receptor-linked hydrolysis of membrane inositol phospholipids (carbachol and phenylephrine) and by agonist linked to activation of adenylate cyclase (isoproterenol) were investigated. 
Material and methods: In anaesthetized rats, submandibular salivation induced by intravenous injection of carbachol, phenylephrine and isoproterenol, was measured and expressed as volume of fluid (microl) elicited per 100 mg wet weight of each gland per minute. The experiments were repeated after acute and chronic treatment of lithium (7 mg kg(-1)). The results were analysed with unpaired t-test. 
Results: Chronic, but not acute lithium treatment significantly decreases carbachol- and phenylephrine-induced salivation while isoproterenol-induced salivation was not changed neither after acute nor after chronic administration of lithium. 
Conclusion: The results suggest that hyposalivation during chronic lithium therapy could be mediated by alterations in the phosphatidylinositol cycle and a consequent lack of inositol after agonist stimulation.",
publisher = "John Wiley & Sons, Inc., Blackwell Munksgaard",
journal = "Oral Diseases",
title = "The effects of acute and chronic lithium treatment on rat submandibular salivation",
volume = "11",
number = "2",
pages = "100-103",
doi = "10.1111/j.1601-0825.2004.01066.x"
}

Popović, J., Kršljak, E., Grbović, L.,& Stojić, D.. (2005). The effects of acute and chronic lithium treatment on rat submandibular salivation. in Oral Diseases
John Wiley & Sons, Inc.., 11(2), 100-103.
https://doi.org/10.1111/j.1601-0825.2004.01066.x

Popović J, Kršljak E, Grbović L, Stojić D. The effects of acute and chronic lithium treatment on rat submandibular salivation. in Oral Diseases. 2005;11(2):100-103.
doi:10.1111/j.1601-0825.2004.01066.x .

Popović, Jelena, Kršljak, Elena, Grbović, Leposava, Stojić, Dragica, "The effects of acute and chronic lithium treatment on rat submandibular salivation" in Oral Diseases, 11, no. 2 (2005):100-103,
https://doi.org/10.1111/j.1601-0825.2004.01066.x . .

TY  - JOUR
AU  - Stojić, Dragica
AU  - Radenković, Miroslav
AU  - Kršljak, Elena
AU  - Popović, Jelena
AU  - Pešić, Srđan
AU  - Grbović, Leposava
PY  - 2003
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2590
AB  - The aim was to examine the influence of the endothelium on acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) functional responses in the isolated glandular branch of rabbit facial artery precontracted with phenylephrine as well as the potential contribution of nitric oxide (NO) and prostanoids in the ACh- and VIP-induced effects. Acetylcholine caused endothelium-dependent and VIP endothelium-independent relaxations of facial artery. The effect of ACh was partly inhibited by NG-monomethyl-l-arginine (l-NMMA, a non-selective NO synthase inhibitor) or by indomethacin (a cyclooxygenase inhibitor) while being completely blocked after concomitant addition of l-NMMA and indomethacin. The relaxation of the facial artery caused by ACh was unaffected by 65 mm KCl. The VIP-induced vasodilation was potentiated by forskolin (an adenylate cyclase stimulator) and partly reduced by l-NMMA or S-methyl-l-thiocitrulline (l-SMTC, a neuronal NO synthase inhibitor), whereas it was unaffected by indomethacin. These results suggest that ACh effects on the rabbit facial artery are mediated through release of endothelium-derived NO and cyclooxygenase products, while the effect of VIP is most probably mediated by an increase of cyclic adenosine 3',5'-monophosphate (cAMP) in vascular smooth muscles and by VIP-induced release of NO from perivascular nerve fibers.
PB  - John Wiley & Sons, Inc.
T2  - European Journal of Oral Sciences
T1  - Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery
VL  - 111
IS  - 2
SP  - 137
EP  - 143
DO  - 10.1034/j.1600-0722.2003.00021.x
ER  - 

@article{
author = "Stojić, Dragica and Radenković, Miroslav and Kršljak, Elena and Popović, Jelena and Pešić, Srđan and Grbović, Leposava",
year = "2003",
abstract = "The aim was to examine the influence of the endothelium on acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) functional responses in the isolated glandular branch of rabbit facial artery precontracted with phenylephrine as well as the potential contribution of nitric oxide (NO) and prostanoids in the ACh- and VIP-induced effects. Acetylcholine caused endothelium-dependent and VIP endothelium-independent relaxations of facial artery. The effect of ACh was partly inhibited by NG-monomethyl-l-arginine (l-NMMA, a non-selective NO synthase inhibitor) or by indomethacin (a cyclooxygenase inhibitor) while being completely blocked after concomitant addition of l-NMMA and indomethacin. The relaxation of the facial artery caused by ACh was unaffected by 65 mm KCl. The VIP-induced vasodilation was potentiated by forskolin (an adenylate cyclase stimulator) and partly reduced by l-NMMA or S-methyl-l-thiocitrulline (l-SMTC, a neuronal NO synthase inhibitor), whereas it was unaffected by indomethacin. These results suggest that ACh effects on the rabbit facial artery are mediated through release of endothelium-derived NO and cyclooxygenase products, while the effect of VIP is most probably mediated by an increase of cyclic adenosine 3',5'-monophosphate (cAMP) in vascular smooth muscles and by VIP-induced release of NO from perivascular nerve fibers.",
publisher = "John Wiley & Sons, Inc.",
journal = "European Journal of Oral Sciences",
title = "Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery",
volume = "111",
number = "2",
pages = "137-143",
doi = "10.1034/j.1600-0722.2003.00021.x"
}

Stojić, D., Radenković, M., Kršljak, E., Popović, J., Pešić, S.,& Grbović, L.. (2003). Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery. in European Journal of Oral Sciences
John Wiley & Sons, Inc.., 111(2), 137-143.
https://doi.org/10.1034/j.1600-0722.2003.00021.x

Stojić D, Radenković M, Kršljak E, Popović J, Pešić S, Grbović L. Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery. in European Journal of Oral Sciences. 2003;111(2):137-143.
doi:10.1034/j.1600-0722.2003.00021.x .

Stojić, Dragica, Radenković, Miroslav, Kršljak, Elena, Popović, Jelena, Pešić, Srđan, Grbović, Leposava, "Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery" in European Journal of Oral Sciences, 111, no. 2 (2003):137-143,
https://doi.org/10.1034/j.1600-0722.2003.00021.x . .

TY  - JOUR
AU  - Stojić, Dragica
AU  - Kršljak, Elena
PY  - 2000
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1110
AB  - Substance P (SP)-induced changes in oxygen consumption of rat subtnandibular, sublingual and parotid gland slices were investigated. SP elicited the concentration-dependent increase of oxygen consumption in all 3 glands. The increase was inhibit able by spamide II, the selective NK1 receptor antagonist, hut not by atropine, the muscarinic receptor antagonist. Respiratory effect of SP required the presence of Ca2+ in the incubation medium and was blocked by ouabain. SP had no significant effect on acetylcholine resting release from all 3 salivary glands. The study indicates that SP activates selective NK1 receptors, which are located only postsynaptically, and produces Ca2+-dependent and oubain-sensitive oxygen consumption in rat major salivary glands.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Stomatology
T1  - Substance P-induced oxygen consumption in rat major salivary glands
VL  - 4
IS  - 1
SP  - 9
EP  - 11
UR  - https://hdl.handle.net/21.15107/rcub_smile_1110
ER  - 

@article{
author = "Stojić, Dragica and Kršljak, Elena",
year = "2000",
abstract = "Substance P (SP)-induced changes in oxygen consumption of rat subtnandibular, sublingual and parotid gland slices were investigated. SP elicited the concentration-dependent increase of oxygen consumption in all 3 glands. The increase was inhibit able by spamide II, the selective NK1 receptor antagonist, hut not by atropine, the muscarinic receptor antagonist. Respiratory effect of SP required the presence of Ca2+ in the incubation medium and was blocked by ouabain. SP had no significant effect on acetylcholine resting release from all 3 salivary glands. The study indicates that SP activates selective NK1 receptors, which are located only postsynaptically, and produces Ca2+-dependent and oubain-sensitive oxygen consumption in rat major salivary glands.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Stomatology",
title = "Substance P-induced oxygen consumption in rat major salivary glands",
volume = "4",
number = "1",
pages = "9-11",
url = "https://hdl.handle.net/21.15107/rcub_smile_1110"
}

Stojić, D.,& Kršljak, E.. (2000). Substance P-induced oxygen consumption in rat major salivary glands. in Balkan Journal of Stomatology
Udruženje stomatologa Balkana., 4(1), 9-11.
https://hdl.handle.net/21.15107/rcub_smile_1110

Stojić D, Kršljak E. Substance P-induced oxygen consumption in rat major salivary glands. in Balkan Journal of Stomatology. 2000;4(1):9-11.
https://hdl.handle.net/21.15107/rcub_smile_1110 .

Stojić, Dragica, Kršljak, Elena, "Substance P-induced oxygen consumption in rat major salivary glands" in Balkan Journal of Stomatology, 4, no. 1 (2000):9-11,
https://hdl.handle.net/21.15107/rcub_smile_1110 .

TY  - THES
AU  - Stojić, Dragica
PY  - 1987
UR  - https://plus.sr.cobiss.net/opac7/bib/74322444
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/212
PB  - Univerzitet u Beogradu, Stomatološki fakultet - Farmakološki institut
T1  - Uticaj farmaka na sadržaj acetilholina i vegetativnu kontrolu sekretornih i respiratornih funkcija pljuvačnih žlezda
UR  - https://hdl.handle.net/21.15107/rcub_smile_212
ER  - 

@phdthesis{
author = "Stojić, Dragica",
year = "1987",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet - Farmakološki institut",
title = "Uticaj farmaka na sadržaj acetilholina i vegetativnu kontrolu sekretornih i respiratornih funkcija pljuvačnih žlezda",
url = "https://hdl.handle.net/21.15107/rcub_smile_212"
}

Stojić, D.. (1987). Uticaj farmaka na sadržaj acetilholina i vegetativnu kontrolu sekretornih i respiratornih funkcija pljuvačnih žlezda. 
Univerzitet u Beogradu, Stomatološki fakultet - Farmakološki institut..
https://hdl.handle.net/21.15107/rcub_smile_212

Stojić D. Uticaj farmaka na sadržaj acetilholina i vegetativnu kontrolu sekretornih i respiratornih funkcija pljuvačnih žlezda. 1987;.
https://hdl.handle.net/21.15107/rcub_smile_212 .

Stojić, Dragica, "Uticaj farmaka na sadržaj acetilholina i vegetativnu kontrolu sekretornih i respiratornih funkcija pljuvačnih žlezda" (1987),
https://hdl.handle.net/21.15107/rcub_smile_212 .

TY  - THES
AU  - Stojić, Dragica
PY  - 1981
UR  - https://plus.sr.cobiss.net/opac7/bib/1024123790
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/143
T1  - Uticaj dikloksacilina na digestivni trakt i kardiovaskularni sistem
UR  - https://hdl.handle.net/21.15107/rcub_smile_143
ER  - 

@mastersthesis{
author = "Stojić, Dragica",
year = "1981",
title = "Uticaj dikloksacilina na digestivni trakt i kardiovaskularni sistem",
url = "https://hdl.handle.net/21.15107/rcub_smile_143"
}

Stojić, D.. (1981). Uticaj dikloksacilina na digestivni trakt i kardiovaskularni sistem. .
https://hdl.handle.net/21.15107/rcub_smile_143

Stojić D. Uticaj dikloksacilina na digestivni trakt i kardiovaskularni sistem. 1981;.
https://hdl.handle.net/21.15107/rcub_smile_143 .

Stojić, Dragica, "Uticaj dikloksacilina na digestivni trakt i kardiovaskularni sistem" (1981),
https://hdl.handle.net/21.15107/rcub_smile_143 .