TY  - JOUR
AU  - Lisul, Bogdan
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Tepavčević, Zvezdana
AU  - Koruga, Đuro
AU  - Grga, Đurica
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2424
AB  - PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.
PB  - Springer Heidelberg, Heidelberg
T2  - Journal of Medical & Biological Engineering
T1  - Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins
VL  - 39
IS  - 6
SP  - 874
EP  - 884
DO  - 10.1007/s40846-019-00473-y
ER  - 

@article{
author = "Lisul, Bogdan and Jelovac, Drago and Petrović, Milan and Tepavčević, Zvezdana and Koruga, Đuro and Grga, Đurica",
year = "2019",
abstract = "PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Journal of Medical & Biological Engineering",
title = "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins",
volume = "39",
number = "6",
pages = "874-884",
doi = "10.1007/s40846-019-00473-y"
}

Lisul, B., Jelovac, D., Petrović, M., Tepavčević, Z., Koruga, Đ.,& Grga, Đ.. (2019). Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering
Springer Heidelberg, Heidelberg., 39(6), 874-884.
https://doi.org/10.1007/s40846-019-00473-y

Lisul B, Jelovac D, Petrović M, Tepavčević Z, Koruga Đ, Grga Đ. Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering. 2019;39(6):874-884.
doi:10.1007/s40846-019-00473-y .

Lisul, Bogdan, Jelovac, Drago, Petrović, Milan, Tepavčević, Zvezdana, Koruga, Đuro, Grga, Đurica, "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins" in Journal of Medical & Biological Engineering, 39, no. 6 (2019):874-884,
https://doi.org/10.1007/s40846-019-00473-y . .

TY  - JOUR
AU  - Mikić, Ilija
AU  - Lisul, Bogdan
AU  - Grga, Đurica
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2431
AB  - Introduction The "Kod Koraba" site is located in the territory of antique Viminacium. Archaeological excavations were carried out from 2005 to 2008. On this occasion, a necropolis with a total of 77 graves was explored, which according to archaeological contributions can be dated to the period from 2nd to 4th century AD (Roman period). The aim of this study was to provide, on the basis of the results of dental anthropological analysis of osteological material from the necropolis "Kod Koraba", data of the dental status and pathological changes of the oral cavity and teeth in human population that inhabited this area of antique Viminacium from 2nd to 4th century AD. Material and method During the archaeological excavations from 2005 to 2008, a total of 77 graves were explored. Of this number, due to lower degree of preservation, the dental status of 45 individuals was analyzed. Of these, 36 belonged to adult individuals and nine were children. Functional methodology used in previous studies of human populations of the prehistoric period was applied in order to compare obtained results with similar ones as well as with the status of the oral cavity and teeth of the current population. Results The obtained results supplemented the picture of dental health status of ancient populations in Viminacium. They indicated high degree of abrasion and dental plaque, the presence of caries within the expected limits for the studied period, as well as the presence of other dental pathologies such as periodontal disease and periapical processes present in the current human population. Conclusion Anatomo-morphological status of the teeth and the jaw of the human population from ancient Viminacium are similar with the characteristics of modern man. Pathological changes of the oro-facial system of modern man were present in the studied human population of Roman period, with different values of their distribution.
AB  - Lokalitet "Kod Koraba" se nalazi na prostoru antičkog Viminacijuma. Arheološka iskopavanja su sprovedena u periodu od 2005. do 2008. godine. Tom prilikom je istražena nekropola sa ukupno 77 grobova koji se prema arheološkim prilozima mogu datovati u period od II do IV veka nove ere (rimski period). Cilj ovog rada je bio da se na osnovu rezultata dentalnoantropološke analize osteološkog materijala iz nekropole "Kod Koraba" upotpune saznanja o dentalnom statusu i patološkim promenama usta i zuba humane populacije koja je nastanjivala prostor antičkog Viminacijuma u periodu od II do IV veka nove ere. Materijal i metod Prilikom arheoloških iskopavanja od 2005. do 2008. godine ukupno je istraženo 77 grobova, od kojih je, usled lošijeg stepena očuvanosti, mogao biti analiziran dentalni status 45 individua. Od tog broja je 36 pripadalo odraslim individuama, a devetoro dečjem uzrastu. Primenjena je metodologija koja je korišćena u prethodnim istraživanjima humanih populacija praistorijskog perioda. Izabrana metodologija je funkcionalna jer se dobijeni rezultati mogu međusobno porediti, kao i sa statusom usta i zuba sadašnje populacije. Rezultati Dobijeni rezultati su upotpunili sliku o zubnozdravstvenom statusu antičkih populacija na Viminacijumu, ukazali na visok stepen abrazije i zubnih naslaga, zastupljenost karijesa u očekivanim granicama za ispitivani period, kao prisustvo i druge dentalne patologije, parodontopatija, periapikalnih procesa, prisutnih i u sadašnjoj humanoj populaciji. Zaključak Na osnovu dobijenih rezultata može se zaključiti da se anatomo-morfološki status zuba i vilica humane populacije sa prostora antičkog Viminacijuma podudaraju sa karakteristikama savremenog čoveka. Patološke promene orofacijalnog sistema savremenog čoveka su prisutne i u ispitivanoj humanoj populaciji rimskog perioda, sa različitim vrednostima njihove distribucije.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Dental anthropological status of the human population found in the Roman site of Viminacium necropolis 'Kod Koraba'
T1  - Dentalnoantropološki status humane populacije antičkog lokaliteta Viminacijum - nekropola 'Kod Koraba'
VL  - 66
IS  - 3
SP  - 140
EP  - 147
DO  - 10.2478/sdj-2019-0015
ER  - 

@article{
author = "Mikić, Ilija and Lisul, Bogdan and Grga, Đurica",
year = "2019",
abstract = "Introduction The "Kod Koraba" site is located in the territory of antique Viminacium. Archaeological excavations were carried out from 2005 to 2008. On this occasion, a necropolis with a total of 77 graves was explored, which according to archaeological contributions can be dated to the period from 2nd to 4th century AD (Roman period). The aim of this study was to provide, on the basis of the results of dental anthropological analysis of osteological material from the necropolis "Kod Koraba", data of the dental status and pathological changes of the oral cavity and teeth in human population that inhabited this area of antique Viminacium from 2nd to 4th century AD. Material and method During the archaeological excavations from 2005 to 2008, a total of 77 graves were explored. Of this number, due to lower degree of preservation, the dental status of 45 individuals was analyzed. Of these, 36 belonged to adult individuals and nine were children. Functional methodology used in previous studies of human populations of the prehistoric period was applied in order to compare obtained results with similar ones as well as with the status of the oral cavity and teeth of the current population. Results The obtained results supplemented the picture of dental health status of ancient populations in Viminacium. They indicated high degree of abrasion and dental plaque, the presence of caries within the expected limits for the studied period, as well as the presence of other dental pathologies such as periodontal disease and periapical processes present in the current human population. Conclusion Anatomo-morphological status of the teeth and the jaw of the human population from ancient Viminacium are similar with the characteristics of modern man. Pathological changes of the oro-facial system of modern man were present in the studied human population of Roman period, with different values of their distribution., Lokalitet "Kod Koraba" se nalazi na prostoru antičkog Viminacijuma. Arheološka iskopavanja su sprovedena u periodu od 2005. do 2008. godine. Tom prilikom je istražena nekropola sa ukupno 77 grobova koji se prema arheološkim prilozima mogu datovati u period od II do IV veka nove ere (rimski period). Cilj ovog rada je bio da se na osnovu rezultata dentalnoantropološke analize osteološkog materijala iz nekropole "Kod Koraba" upotpune saznanja o dentalnom statusu i patološkim promenama usta i zuba humane populacije koja je nastanjivala prostor antičkog Viminacijuma u periodu od II do IV veka nove ere. Materijal i metod Prilikom arheoloških iskopavanja od 2005. do 2008. godine ukupno je istraženo 77 grobova, od kojih je, usled lošijeg stepena očuvanosti, mogao biti analiziran dentalni status 45 individua. Od tog broja je 36 pripadalo odraslim individuama, a devetoro dečjem uzrastu. Primenjena je metodologija koja je korišćena u prethodnim istraživanjima humanih populacija praistorijskog perioda. Izabrana metodologija je funkcionalna jer se dobijeni rezultati mogu međusobno porediti, kao i sa statusom usta i zuba sadašnje populacije. Rezultati Dobijeni rezultati su upotpunili sliku o zubnozdravstvenom statusu antičkih populacija na Viminacijumu, ukazali na visok stepen abrazije i zubnih naslaga, zastupljenost karijesa u očekivanim granicama za ispitivani period, kao prisustvo i druge dentalne patologije, parodontopatija, periapikalnih procesa, prisutnih i u sadašnjoj humanoj populaciji. Zaključak Na osnovu dobijenih rezultata može se zaključiti da se anatomo-morfološki status zuba i vilica humane populacije sa prostora antičkog Viminacijuma podudaraju sa karakteristikama savremenog čoveka. Patološke promene orofacijalnog sistema savremenog čoveka su prisutne i u ispitivanoj humanoj populaciji rimskog perioda, sa različitim vrednostima njihove distribucije.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Dental anthropological status of the human population found in the Roman site of Viminacium necropolis 'Kod Koraba', Dentalnoantropološki status humane populacije antičkog lokaliteta Viminacijum - nekropola 'Kod Koraba'",
volume = "66",
number = "3",
pages = "140-147",
doi = "10.2478/sdj-2019-0015"
}

Mikić, I., Lisul, B.,& Grga, Đ.. (2019). Dental anthropological status of the human population found in the Roman site of Viminacium necropolis 'Kod Koraba'. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 66(3), 140-147.
https://doi.org/10.2478/sdj-2019-0015

Mikić I, Lisul B, Grga Đ. Dental anthropological status of the human population found in the Roman site of Viminacium necropolis 'Kod Koraba'. in Stomatološki glasnik Srbije. 2019;66(3):140-147.
doi:10.2478/sdj-2019-0015 .

Mikić, Ilija, Lisul, Bogdan, Grga, Đurica, "Dental anthropological status of the human population found in the Roman site of Viminacium necropolis 'Kod Koraba'" in Stomatološki glasnik Srbije, 66, no. 3 (2019):140-147,
https://doi.org/10.2478/sdj-2019-0015 . .

TY  - JOUR
AU  - Grga, Đurica
AU  - Mikić, Ilija
AU  - Lisul, Bogdan
AU  - Zlopaša, Tamara
AU  - Dželetović, Bojan
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2250
AB  - Introduction Knowledge of biological and cultural heritage represents a significant basis for the advance of human civilization. The aim of this study was to determine and define dental health status of pre-historic people of the Vinca culture. Material and method Study included twenty skeleton remnants of different gender and age from anthropological series of Gomolava. Skeletons originated from one necropolis and two individual graves dating from mid and early Neolithic periods of the Vinca culture. Based on radiocarbon analysis absolute skeletal age was determined to date within the periods from 5848±38 to 5739±35 BC. Preservation of skeletons varied from completely preserved skulls and jaws to fragmented parts of jaws. Data analysis was performed with methodology used in the research of human population teeth and jaws from the Lepenski Vir culture. Results Results showed high level of teeth abrasion (98,1%), medium level of dental calculus deposits (44,9%), low level of tooth decay, significant number of retained roots, as well as the occurrence of periapical lesions and periodontal disease within the neolith population of Gomolava site. Conclusion Taking into account absolute age of examined skeletons, collected data are very significant, from the perspective of its wide content. From a pathological perspective, teeth abrasion stands out as a dominant feature, while tooth decay fits within standard values for human population of the neolith period.
AB  - Uvod Poznavanje biološkog i kulturnog nasleđa je bitna pretpostavka daljeg civilizacijskog napretka. Cilj ovog rada je bio da se na osnovu očuvanih humanih skeletnih ostataka lobanja i vilica antropološke serije sa Gomolave, analizom zuba i vilica, sagleda i definiše zubno-zdravstveni status praistorijskih ljudi iz perioda Vinčanske kulture. Materijal i metod Istraživanja su obuhvatila dvadeset skeletnih ostataka, različitog pola i individualne starosti. Skeleti potiču iz jedne nekropole i dva pojedinačna groba srednjeg i mlađeg neolita iz perioda Vinčanske kulture. Apsolutna starost skeleta je radio- karbonskom analizom ugljenika C14 datovana u periodu od 5848. ±38 do 5739. ±35 godina pre nove ere. Očuvanost skeleta je bila različita i kretala se od kompletno sačuvanih lobanja i vilica do fragmentovanih delova vilica. Podaci su analizirani metodologijom koja je primenjivana u istraživanjima zuba i vilica humane populacije Kulture Lepenskog Vira. Rezultati Rezultati su ukazali na visok stepen abrazije zuba (98.1%) neolitske populacije sa lokaliteta Gomolava, umereni stepen naslaga (44,9%), nizak stepen karijesa, značajan broj zaostalih korenova, kao i pojavu periapikalnih procesa i parodontopatije. Zaključak Uzimajući u obzir apsolutnu starost ispitivanih skeleta, prikupljeni podaci su izuzetno vredni po obimu građe i njenom sadržaju. Patološkom slikom dominira abrazija, dok je karijes prisutan u okviru standardnih vrednosti za humanu populaciju iz perioda neolita.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Dental and jaws status in pre-historic human population of the Gomolava site
T1  - Status zuba i vilica praistorijske humane populacije sa lokaliteta Gomolava
VL  - 64
IS  - 1
SP  - 24
EP  - 31
DO  - 10.1515/sdj-2017-0003
ER  - 

@article{
author = "Grga, Đurica and Mikić, Ilija and Lisul, Bogdan and Zlopaša, Tamara and Dželetović, Bojan",
year = "2017",
abstract = "Introduction Knowledge of biological and cultural heritage represents a significant basis for the advance of human civilization. The aim of this study was to determine and define dental health status of pre-historic people of the Vinca culture. Material and method Study included twenty skeleton remnants of different gender and age from anthropological series of Gomolava. Skeletons originated from one necropolis and two individual graves dating from mid and early Neolithic periods of the Vinca culture. Based on radiocarbon analysis absolute skeletal age was determined to date within the periods from 5848±38 to 5739±35 BC. Preservation of skeletons varied from completely preserved skulls and jaws to fragmented parts of jaws. Data analysis was performed with methodology used in the research of human population teeth and jaws from the Lepenski Vir culture. Results Results showed high level of teeth abrasion (98,1%), medium level of dental calculus deposits (44,9%), low level of tooth decay, significant number of retained roots, as well as the occurrence of periapical lesions and periodontal disease within the neolith population of Gomolava site. Conclusion Taking into account absolute age of examined skeletons, collected data are very significant, from the perspective of its wide content. From a pathological perspective, teeth abrasion stands out as a dominant feature, while tooth decay fits within standard values for human population of the neolith period., Uvod Poznavanje biološkog i kulturnog nasleđa je bitna pretpostavka daljeg civilizacijskog napretka. Cilj ovog rada je bio da se na osnovu očuvanih humanih skeletnih ostataka lobanja i vilica antropološke serije sa Gomolave, analizom zuba i vilica, sagleda i definiše zubno-zdravstveni status praistorijskih ljudi iz perioda Vinčanske kulture. Materijal i metod Istraživanja su obuhvatila dvadeset skeletnih ostataka, različitog pola i individualne starosti. Skeleti potiču iz jedne nekropole i dva pojedinačna groba srednjeg i mlađeg neolita iz perioda Vinčanske kulture. Apsolutna starost skeleta je radio- karbonskom analizom ugljenika C14 datovana u periodu od 5848. ±38 do 5739. ±35 godina pre nove ere. Očuvanost skeleta je bila različita i kretala se od kompletno sačuvanih lobanja i vilica do fragmentovanih delova vilica. Podaci su analizirani metodologijom koja je primenjivana u istraživanjima zuba i vilica humane populacije Kulture Lepenskog Vira. Rezultati Rezultati su ukazali na visok stepen abrazije zuba (98.1%) neolitske populacije sa lokaliteta Gomolava, umereni stepen naslaga (44,9%), nizak stepen karijesa, značajan broj zaostalih korenova, kao i pojavu periapikalnih procesa i parodontopatije. Zaključak Uzimajući u obzir apsolutnu starost ispitivanih skeleta, prikupljeni podaci su izuzetno vredni po obimu građe i njenom sadržaju. Patološkom slikom dominira abrazija, dok je karijes prisutan u okviru standardnih vrednosti za humanu populaciju iz perioda neolita.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Dental and jaws status in pre-historic human population of the Gomolava site, Status zuba i vilica praistorijske humane populacije sa lokaliteta Gomolava",
volume = "64",
number = "1",
pages = "24-31",
doi = "10.1515/sdj-2017-0003"
}

Grga, Đ., Mikić, I., Lisul, B., Zlopaša, T.,& Dželetović, B.. (2017). Dental and jaws status in pre-historic human population of the Gomolava site. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 64(1), 24-31.
https://doi.org/10.1515/sdj-2017-0003

Grga Đ, Mikić I, Lisul B, Zlopaša T, Dželetović B. Dental and jaws status in pre-historic human population of the Gomolava site. in Stomatološki glasnik Srbije. 2017;64(1):24-31.
doi:10.1515/sdj-2017-0003 .

Grga, Đurica, Mikić, Ilija, Lisul, Bogdan, Zlopaša, Tamara, Dželetović, Bojan, "Dental and jaws status in pre-historic human population of the Gomolava site" in Stomatološki glasnik Srbije, 64, no. 1 (2017):24-31,
https://doi.org/10.1515/sdj-2017-0003 . .