TY  - JOUR
AU  - Đurić, Milanko
AU  - Janković, Ljiljana
AU  - Jovanović, Tanja
AU  - Pavlica, Dušan
AU  - Brkić, Snežana
AU  - Knežević, Aleksandra
AU  - Marković, Dubravka
AU  - Milašin, Jelena
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1504
AB  - Oral reactivation of latent Herpes simplex virus (HSV) infection may easily occur in cancer patients. Virus reactivation can cause oral mucosa damage, worsen already existing lesions caused by stomatotoxic effect of cancer therapy and, whether symptomatic or asymptomatic, ample spreading and promote viral transmission. Polymerase chain reaction (PCR), cell-culture and direct immunofluorescence have been used to determine the frequency of oral HSV reactivation in 60 patients undergoing chemotherapy for different malignancies. By means of PCR, the presence of viral DNA was detected in 71.7% of patients prior to chemotherapy and in 85.0% after chemotherapy. 33.3% of patients before and 40.0% after chemotherapy were viral-culture positive, while 3.3% of patients before and 11.7% after chemotherapy were positive as shown by direct immunofluorescence. No significant difference in HSV-1 reactivation was found before and after chemotherapy. In addition, no significant difference was found when comparing HSV-1 reactivation in patients with and without mucositis. HSV-2 was not detected in any of the patients. Reactivation of latent HSV is exceptionally frequent in cancer patients. The results of this study suggest that virus reactivation occurs independently of cancer chemotherapy. The potential role of HSV reactivation in oral mucosa damage remains unclear.
PB  - Wiley, Hoboken
T2  - Journal of Oral Pathology & Medicine
T1  - Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection
VL  - 38
IS  - 2
SP  - 167
EP  - 173
DO  - 10.1111/j.1600-0714.2008.00684.x
ER  - 

@article{
author = "Đurić, Milanko and Janković, Ljiljana and Jovanović, Tanja and Pavlica, Dušan and Brkić, Snežana and Knežević, Aleksandra and Marković, Dubravka and Milašin, Jelena",
year = "2009",
abstract = "Oral reactivation of latent Herpes simplex virus (HSV) infection may easily occur in cancer patients. Virus reactivation can cause oral mucosa damage, worsen already existing lesions caused by stomatotoxic effect of cancer therapy and, whether symptomatic or asymptomatic, ample spreading and promote viral transmission. Polymerase chain reaction (PCR), cell-culture and direct immunofluorescence have been used to determine the frequency of oral HSV reactivation in 60 patients undergoing chemotherapy for different malignancies. By means of PCR, the presence of viral DNA was detected in 71.7% of patients prior to chemotherapy and in 85.0% after chemotherapy. 33.3% of patients before and 40.0% after chemotherapy were viral-culture positive, while 3.3% of patients before and 11.7% after chemotherapy were positive as shown by direct immunofluorescence. No significant difference in HSV-1 reactivation was found before and after chemotherapy. In addition, no significant difference was found when comparing HSV-1 reactivation in patients with and without mucositis. HSV-2 was not detected in any of the patients. Reactivation of latent HSV is exceptionally frequent in cancer patients. The results of this study suggest that virus reactivation occurs independently of cancer chemotherapy. The potential role of HSV reactivation in oral mucosa damage remains unclear.",
publisher = "Wiley, Hoboken",
journal = "Journal of Oral Pathology & Medicine",
title = "Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection",
volume = "38",
number = "2",
pages = "167-173",
doi = "10.1111/j.1600-0714.2008.00684.x"
}

Đurić, M., Janković, L., Jovanović, T., Pavlica, D., Brkić, S., Knežević, A., Marković, D.,& Milašin, J.. (2009). Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection. in Journal of Oral Pathology & Medicine
Wiley, Hoboken., 38(2), 167-173.
https://doi.org/10.1111/j.1600-0714.2008.00684.x

Đurić M, Janković L, Jovanović T, Pavlica D, Brkić S, Knežević A, Marković D, Milašin J. Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection. in Journal of Oral Pathology & Medicine. 2009;38(2):167-173.
doi:10.1111/j.1600-0714.2008.00684.x .

Đurić, Milanko, Janković, Ljiljana, Jovanović, Tanja, Pavlica, Dušan, Brkić, Snežana, Knežević, Aleksandra, Marković, Dubravka, Milašin, Jelena, "Prevalence of oral herpes simplex virus reactivation in cancer patients: a comparison of different techniques of viral detection" in Journal of Oral Pathology & Medicine, 38, no. 2 (2009):167-173,
https://doi.org/10.1111/j.1600-0714.2008.00684.x . .