TY  - JOUR
AU  - Bogdanović, Ljiljana
AU  - Lazić, Miodrag
AU  - Bogdanović, Jelena
AU  - Soldatović, Ivan
AU  - Nikolić, Nadja
AU  - Radunović, Milena
AU  - Radojević-Škodrić, Sanja
AU  - Milašin, Jelena
AU  - Basta-Jovanović, Gordana
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2182
AB  - Purpose: Survivin is thought to play an important role in carcinogenesis and is found to be associated with poor clinical outcome in various malignancies. Gene-31 G/C polymorphism has been identified as a risk factor for the development of several types of tumors. The purpose of this study was to investigate the association between survivin gene promoter-31C/G polymorphism and urothelial carcinoma (UC) risk in Serbian population and to compare the different expressions of survivin in UC of different disease stages, histological grades and tumor location in the upper or lower urinary tract. Methods: DNA from 94 patients with primary UC and from 82 healthy subjects was subjected to PCR restriction fragment length polymorphism analysis (PCR-RFLP) to identify individual genotypes. UC samples were subjected to immunohistochemical analysis to assess survivin expression in these lesions. Results: It was observed that the frequency of G/G genotype was greater in patients with UC (58.7%) than in controls (32%). Compared with study subjects carrying the C/G or C/C genotypes, significantly increased UC risk was found for individuals carrying the G/G genotype. Those carrying the G/G genotype had a significantly increased UC risk compared with those with C/G or C/C genotypes. Patients with UC carrying the G/G genotype had a greater prevalence of muscle -invading (stage T2-T4), high-grade (G2) tumor and immunohistochemicaly overexpressed survivin compared with those carrying the C/G or C/C genotypes. Conclusions: G/G genotype of the -31C/G polymorphism might be a risk factor for UC development.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population
VL  - 22
IS  - 1
SP  - 270
EP  - 277
UR  - https://hdl.handle.net/21.15107/rcub_smile_2182
ER  - 

@article{
author = "Bogdanović, Ljiljana and Lazić, Miodrag and Bogdanović, Jelena and Soldatović, Ivan and Nikolić, Nadja and Radunović, Milena and Radojević-Škodrić, Sanja and Milašin, Jelena and Basta-Jovanović, Gordana",
year = "2017",
abstract = "Purpose: Survivin is thought to play an important role in carcinogenesis and is found to be associated with poor clinical outcome in various malignancies. Gene-31 G/C polymorphism has been identified as a risk factor for the development of several types of tumors. The purpose of this study was to investigate the association between survivin gene promoter-31C/G polymorphism and urothelial carcinoma (UC) risk in Serbian population and to compare the different expressions of survivin in UC of different disease stages, histological grades and tumor location in the upper or lower urinary tract. Methods: DNA from 94 patients with primary UC and from 82 healthy subjects was subjected to PCR restriction fragment length polymorphism analysis (PCR-RFLP) to identify individual genotypes. UC samples were subjected to immunohistochemical analysis to assess survivin expression in these lesions. Results: It was observed that the frequency of G/G genotype was greater in patients with UC (58.7%) than in controls (32%). Compared with study subjects carrying the C/G or C/C genotypes, significantly increased UC risk was found for individuals carrying the G/G genotype. Those carrying the G/G genotype had a significantly increased UC risk compared with those with C/G or C/C genotypes. Patients with UC carrying the G/G genotype had a greater prevalence of muscle -invading (stage T2-T4), high-grade (G2) tumor and immunohistochemicaly overexpressed survivin compared with those carrying the C/G or C/C genotypes. Conclusions: G/G genotype of the -31C/G polymorphism might be a risk factor for UC development.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population",
volume = "22",
number = "1",
pages = "270-277",
url = "https://hdl.handle.net/21.15107/rcub_smile_2182"
}

Bogdanović, L., Lazić, M., Bogdanović, J., Soldatović, I., Nikolić, N., Radunović, M., Radojević-Škodrić, S., Milašin, J.,& Basta-Jovanović, G.. (2017). Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 22(1), 270-277.
https://hdl.handle.net/21.15107/rcub_smile_2182

Bogdanović L, Lazić M, Bogdanović J, Soldatović I, Nikolić N, Radunović M, Radojević-Škodrić S, Milašin J, Basta-Jovanović G. Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population. in Journal of BUON. 2017;22(1):270-277.
https://hdl.handle.net/21.15107/rcub_smile_2182 .

Bogdanović, Ljiljana, Lazić, Miodrag, Bogdanović, Jelena, Soldatović, Ivan, Nikolić, Nadja, Radunović, Milena, Radojević-Škodrić, Sanja, Milašin, Jelena, Basta-Jovanović, Gordana, "Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population" in Journal of BUON, 22, no. 1 (2017):270-277,
https://hdl.handle.net/21.15107/rcub_smile_2182 .

TY  - JOUR
AU  - Latić, Dragana
AU  - Radojević-Škodrić, Sanja
AU  - Nikolić, Srđan
AU  - Prvanović, Mirjana
AU  - Lazić, Miodrag
AU  - Džamić, Zoran
AU  - Bogdanović, Ljiljana
AU  - Radunović, Milena
AU  - Vuković, Marina
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2206
AB  - Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma
VL  - 22
IS  - 5
SP  - 1322
EP  - 1327
UR  - https://hdl.handle.net/21.15107/rcub_smile_2206
ER  - 

@article{
author = "Latić, Dragana and Radojević-Škodrić, Sanja and Nikolić, Srđan and Prvanović, Mirjana and Lazić, Miodrag and Džamić, Zoran and Bogdanović, Ljiljana and Radunović, Milena and Vuković, Marina",
year = "2017",
abstract = "Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma",
volume = "22",
number = "5",
pages = "1322-1327",
url = "https://hdl.handle.net/21.15107/rcub_smile_2206"
}

Latić, D., Radojević-Škodrić, S., Nikolić, S., Prvanović, M., Lazić, M., Džamić, Z., Bogdanović, L., Radunović, M.,& Vuković, M.. (2017). Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 22(5), 1322-1327.
https://hdl.handle.net/21.15107/rcub_smile_2206

Latić D, Radojević-Škodrić S, Nikolić S, Prvanović M, Lazić M, Džamić Z, Bogdanović L, Radunović M, Vuković M. Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma. in Journal of BUON. 2017;22(5):1322-1327.
https://hdl.handle.net/21.15107/rcub_smile_2206 .

Latić, Dragana, Radojević-Škodrić, Sanja, Nikolić, Srđan, Prvanović, Mirjana, Lazić, Miodrag, Džamić, Zoran, Bogdanović, Ljiljana, Radunović, Milena, Vuković, Marina, "Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma" in Journal of BUON, 22, no. 5 (2017):1322-1327,
https://hdl.handle.net/21.15107/rcub_smile_2206 .

TY  - JOUR
AU  - Radojević-Škodrić, Sanja
AU  - Đuricić, S.
AU  - Vučković, Mila
AU  - Dimitrijević, I.
AU  - Lazić, Miodrag
AU  - Stojšić, Z.
AU  - Brašanac, Dimitrije
AU  - Basta-Jovanović, Gordana
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1375
AB  - Abnormalities in cell cycle regulators and subsequent deregulation of G1-S transition may be one of the most important biological events in the malignant transformation of cells. The aim of this study was to investigate the expression of Cyclin E in the normal kidney, and in Wilms tumor, and to correlate the results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in lungs and one case of normal renal tissue. Correlation of semiquantitatively scored cyclin E levels with histopathological parameters was performed for all cases. Diffuse expression of cyclin E was more frequent in the blastemal (without epithelial component) then in the epithelial (without blastemal) component. This correlation showed high significance (p=0.001). Diffuse expression of cyclin E was more frequent in stage III/IV/V (71.4%) than in stage I/II (42.9%), showing no significant correlation (p>0.05). The intermediate risk group of Wilms tumor showed more frequent cyclin E diffuse expression (66.7%) in comparison with high risk cases (20%), showing statistical significance (p lt 0.05). Our findings suggest that diffuse expression of cyclin E is associated with the prognostic group and tumor stage. Also, cyclin E expression is more pronounced in the blastemal component than in the epithelial component.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria
T1  - Immunohistochemical analysis of cyclin E in Wilms tumors
VL  - 57
IS  - 5-6
SP  - 453
EP  - 464
DO  - 10.2298/AVB0706453R
ER  - 

@article{
author = "Radojević-Škodrić, Sanja and Đuricić, S. and Vučković, Mila and Dimitrijević, I. and Lazić, Miodrag and Stojšić, Z. and Brašanac, Dimitrije and Basta-Jovanović, Gordana",
year = "2007",
abstract = "Abnormalities in cell cycle regulators and subsequent deregulation of G1-S transition may be one of the most important biological events in the malignant transformation of cells. The aim of this study was to investigate the expression of Cyclin E in the normal kidney, and in Wilms tumor, and to correlate the results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in lungs and one case of normal renal tissue. Correlation of semiquantitatively scored cyclin E levels with histopathological parameters was performed for all cases. Diffuse expression of cyclin E was more frequent in the blastemal (without epithelial component) then in the epithelial (without blastemal) component. This correlation showed high significance (p=0.001). Diffuse expression of cyclin E was more frequent in stage III/IV/V (71.4%) than in stage I/II (42.9%), showing no significant correlation (p>0.05). The intermediate risk group of Wilms tumor showed more frequent cyclin E diffuse expression (66.7%) in comparison with high risk cases (20%), showing statistical significance (p lt 0.05). Our findings suggest that diffuse expression of cyclin E is associated with the prognostic group and tumor stage. Also, cyclin E expression is more pronounced in the blastemal component than in the epithelial component.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria",
title = "Immunohistochemical analysis of cyclin E in Wilms tumors",
volume = "57",
number = "5-6",
pages = "453-464",
doi = "10.2298/AVB0706453R"
}

Radojević-Škodrić, S., Đuricić, S., Vučković, M., Dimitrijević, I., Lazić, M., Stojšić, Z., Brašanac, D.,& Basta-Jovanović, G.. (2007). Immunohistochemical analysis of cyclin E in Wilms tumors. in Acta Veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 57(5-6), 453-464.
https://doi.org/10.2298/AVB0706453R

Radojević-Škodrić S, Đuricić S, Vučković M, Dimitrijević I, Lazić M, Stojšić Z, Brašanac D, Basta-Jovanović G. Immunohistochemical analysis of cyclin E in Wilms tumors. in Acta Veterinaria. 2007;57(5-6):453-464.
doi:10.2298/AVB0706453R .

Radojević-Škodrić, Sanja, Đuricić, S., Vučković, Mila, Dimitrijević, I., Lazić, Miodrag, Stojšić, Z., Brašanac, Dimitrije, Basta-Jovanović, Gordana, "Immunohistochemical analysis of cyclin E in Wilms tumors" in Acta Veterinaria, 57, no. 5-6 (2007):453-464,
https://doi.org/10.2298/AVB0706453R . .