TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Radojević-Škodrić, Sanja
AU  - Brašanac, Dimitrije
AU  - Đuricić, S.
AU  - Milašin, Jelena
AU  - Bogdanović, L.
AU  - Oprić, D.
AU  - Savin, M.
AU  - Baralić, I.
AU  - Jovanović, M.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1747
AB  - Purpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Prognostic value of survivin expression in Wilms tumor
VL  - 17
IS  - 1
SP  - 168
EP  - 173
UR  - https://hdl.handle.net/21.15107/rcub_smile_1747
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Radojević-Škodrić, Sanja and Brašanac, Dimitrije and Đuricić, S. and Milašin, Jelena and Bogdanović, L. and Oprić, D. and Savin, M. and Baralić, I. and Jovanović, M.",
year = "2012",
abstract = "Purpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Prognostic value of survivin expression in Wilms tumor",
volume = "17",
number = "1",
pages = "168-173",
url = "https://hdl.handle.net/21.15107/rcub_smile_1747"
}

Basta-Jovanović, G., Radojević-Škodrić, S., Brašanac, D., Đuricić, S., Milašin, J., Bogdanović, L., Oprić, D., Savin, M., Baralić, I.,& Jovanović, M.. (2012). Prognostic value of survivin expression in Wilms tumor. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 17(1), 168-173.
https://hdl.handle.net/21.15107/rcub_smile_1747

Basta-Jovanović G, Radojević-Škodrić S, Brašanac D, Đuricić S, Milašin J, Bogdanović L, Oprić D, Savin M, Baralić I, Jovanović M. Prognostic value of survivin expression in Wilms tumor. in Journal of BUON. 2012;17(1):168-173.
https://hdl.handle.net/21.15107/rcub_smile_1747 .

Basta-Jovanović, Gordana, Radojević-Škodrić, Sanja, Brašanac, Dimitrije, Đuricić, S., Milašin, Jelena, Bogdanović, L., Oprić, D., Savin, M., Baralić, I., Jovanović, M., "Prognostic value of survivin expression in Wilms tumor" in Journal of BUON, 17, no. 1 (2012):168-173,
https://hdl.handle.net/21.15107/rcub_smile_1747 .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Radojević-Škodrić, Sanja
AU  - Jovanović, M.
AU  - Bogdanović, L.
AU  - Bogdanović, R.
AU  - Ležaić, Višnja
AU  - Nesić, V.
AU  - Dikman, S.
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1393
AB  - INTRODUCTION: Two types of hereditary nephritis, nonprogressive and progressive, clinically present as asymptomatic haematuria, sometimes combined with proteinuria. At the onset, in both types, light microscopic changes are minimal, immunofluorescence findings are negative, and diagnosis can be made only upon electron microscopic findings that are considered to be specific. OBJECTIVE: The aim of this study was to determine the significance of Goodpasture antigen detection in diagnosis of progressive and nonprogressive hereditary nephritis in its early phase. METHOD: Analysis of renal biopsy specimens was done in patients with hereditary nephritis that were followed from 1990 to 2005. Progression of renal disease was examined in 14 patients with Alport's syndrome, 10 patients with thin basement membrane disease, and 6 patients with unclassified hereditary nephritis diagnosed. For all these cases, indirect immunofluorescence study with serum from a patient with high titer of Goodpasture autoantibodies that recognize the antigenic determinants in human glomerular and tubular basement membrane was performed. RESULTS: In 11 out of 14 cases diagnosed as Alport's syndrome, there was negative staining with Goodpasture serum, and in 3 additional cases with Alport's syndrome, expression of Goodpasture antigen in glomerular basement membrane and thin basement membrane was highly reduced. In all 10 patients with thin basement membrane disease, immunofluorescence showed intensive, bright linear staining with Goodpasture serum along glomerular and tubular basement membrane. In 2 out of 6 patients with unclassified hereditary nephritis, Goodpasture antigen expression was very strong, in one patient it was very reduced, and in 3 patients it was negative. CONCLUSION: The results of our study show that Goodpasture antigen detection plays a very important role in differential diagnosis of progressive and nonpregressive hereditary nephritis, particularly in early phases of the disease.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The significance of Goodpasture antigen in hereditary nephritis
VL  - 136 Suppl 4
SP  - 282
EP  - 286
DO  - 10.2298/SARH08S4282B
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Radojević-Škodrić, Sanja and Jovanović, M. and Bogdanović, L. and Bogdanović, R. and Ležaić, Višnja and Nesić, V. and Dikman, S.",
year = "2008",
abstract = "INTRODUCTION: Two types of hereditary nephritis, nonprogressive and progressive, clinically present as asymptomatic haematuria, sometimes combined with proteinuria. At the onset, in both types, light microscopic changes are minimal, immunofluorescence findings are negative, and diagnosis can be made only upon electron microscopic findings that are considered to be specific. OBJECTIVE: The aim of this study was to determine the significance of Goodpasture antigen detection in diagnosis of progressive and nonprogressive hereditary nephritis in its early phase. METHOD: Analysis of renal biopsy specimens was done in patients with hereditary nephritis that were followed from 1990 to 2005. Progression of renal disease was examined in 14 patients with Alport's syndrome, 10 patients with thin basement membrane disease, and 6 patients with unclassified hereditary nephritis diagnosed. For all these cases, indirect immunofluorescence study with serum from a patient with high titer of Goodpasture autoantibodies that recognize the antigenic determinants in human glomerular and tubular basement membrane was performed. RESULTS: In 11 out of 14 cases diagnosed as Alport's syndrome, there was negative staining with Goodpasture serum, and in 3 additional cases with Alport's syndrome, expression of Goodpasture antigen in glomerular basement membrane and thin basement membrane was highly reduced. In all 10 patients with thin basement membrane disease, immunofluorescence showed intensive, bright linear staining with Goodpasture serum along glomerular and tubular basement membrane. In 2 out of 6 patients with unclassified hereditary nephritis, Goodpasture antigen expression was very strong, in one patient it was very reduced, and in 3 patients it was negative. CONCLUSION: The results of our study show that Goodpasture antigen detection plays a very important role in differential diagnosis of progressive and nonpregressive hereditary nephritis, particularly in early phases of the disease.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The significance of Goodpasture antigen in hereditary nephritis",
volume = "136 Suppl 4",
pages = "282-286",
doi = "10.2298/SARH08S4282B"
}

Basta-Jovanović, G., Radojević-Škodrić, S., Jovanović, M., Bogdanović, L., Bogdanović, R., Ležaić, V., Nesić, V.,& Dikman, S.. (2008). The significance of Goodpasture antigen in hereditary nephritis. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 136 Suppl 4, 282-286.
https://doi.org/10.2298/SARH08S4282B

Basta-Jovanović G, Radojević-Škodrić S, Jovanović M, Bogdanović L, Bogdanović R, Ležaić V, Nesić V, Dikman S. The significance of Goodpasture antigen in hereditary nephritis. in Srpski arhiv za celokupno lekarstvo. 2008;136 Suppl 4:282-286.
doi:10.2298/SARH08S4282B .

Basta-Jovanović, Gordana, Radojević-Škodrić, Sanja, Jovanović, M., Bogdanović, L., Bogdanović, R., Ležaić, Višnja, Nesić, V., Dikman, S., "The significance of Goodpasture antigen in hereditary nephritis" in Srpski arhiv za celokupno lekarstvo, 136 Suppl 4 (2008):282-286,
https://doi.org/10.2298/SARH08S4282B . .

TY  - JOUR
AU  - Radojević-Škodrić, Sanja
AU  - Bogdanović, L.
AU  - Jovanović, M.
AU  - Baralić, I.
AU  - Savin, M.
AU  - Basta-Jovanović, Gordana
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1392
AB  - INTRODUCTION: Polycystic kidney disease is an inherited kidney disease that affects both kidneys and it is characterized by diffuse replacement of renal parenchyma by thousands of microcysts. In time, renal insufficiency develops. There are two forms of PKD: ADPKD, which is detected in adults (children are rarely affected), and ARPK, which is detected in neonates (later presentations do occur, but rarely). OBJECTIVE: The aim of this study was to analyse frequency of polycystic kidney disease, clinical data and morphological characteristics. METHOD: At the Institute of Pathology, School of Medicine, Belgrade, there were detected 33 cases of ADPKD and 20 cases of ARPKD between 1987 and 2007. RESULTS: There were no differences between incidence of ADPKD in males and females. Average age of patients with ADPKD was 52 years. In 20 (66.7%) cases of ADPKD there were neither extrarenal cysts nor extrarenal manifestations detected. In other 13 cases, we detected extrarenal cysts: hepatic cysts in 8 cases, pancreatic cysts in 5 cases. In two cases, hepatic cysts were associated with intracranial (arachnoid cysts) and extracranial aneurysms. The most frequent cause of death in patients with ADPKD was end-stage disease. ARPKD affects more often male children compared to female. 70% of children with ARPKD were male. The mean age of patients with ARPKD was 1 month. 5 patients (40%) had hepatic fibrosis. The most frequent cause of death was respiratory insufficiency (75%). In 25% of patients, the cause of death was sepsis and renal insufficiency. CONCLUSION: Morphological and clinical manifestations of the analysed cases of both types of PKD are fairly consistent with literature data. Better knowing of aethiopathogenesis of PKD will facilitate early diagnosis, based on clinical and morphological characteristics and better management of the disease.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Polycystic kidney disease--autopsy review from the period 1987-2007
VL  - 136 Suppl 4
SP  - 294
EP  - 297
DO  - 10.2298/SARH08S4294R
ER  - 

@article{
author = "Radojević-Škodrić, Sanja and Bogdanović, L. and Jovanović, M. and Baralić, I. and Savin, M. and Basta-Jovanović, Gordana",
year = "2008",
abstract = "INTRODUCTION: Polycystic kidney disease is an inherited kidney disease that affects both kidneys and it is characterized by diffuse replacement of renal parenchyma by thousands of microcysts. In time, renal insufficiency develops. There are two forms of PKD: ADPKD, which is detected in adults (children are rarely affected), and ARPK, which is detected in neonates (later presentations do occur, but rarely). OBJECTIVE: The aim of this study was to analyse frequency of polycystic kidney disease, clinical data and morphological characteristics. METHOD: At the Institute of Pathology, School of Medicine, Belgrade, there were detected 33 cases of ADPKD and 20 cases of ARPKD between 1987 and 2007. RESULTS: There were no differences between incidence of ADPKD in males and females. Average age of patients with ADPKD was 52 years. In 20 (66.7%) cases of ADPKD there were neither extrarenal cysts nor extrarenal manifestations detected. In other 13 cases, we detected extrarenal cysts: hepatic cysts in 8 cases, pancreatic cysts in 5 cases. In two cases, hepatic cysts were associated with intracranial (arachnoid cysts) and extracranial aneurysms. The most frequent cause of death in patients with ADPKD was end-stage disease. ARPKD affects more often male children compared to female. 70% of children with ARPKD were male. The mean age of patients with ARPKD was 1 month. 5 patients (40%) had hepatic fibrosis. The most frequent cause of death was respiratory insufficiency (75%). In 25% of patients, the cause of death was sepsis and renal insufficiency. CONCLUSION: Morphological and clinical manifestations of the analysed cases of both types of PKD are fairly consistent with literature data. Better knowing of aethiopathogenesis of PKD will facilitate early diagnosis, based on clinical and morphological characteristics and better management of the disease.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Polycystic kidney disease--autopsy review from the period 1987-2007",
volume = "136 Suppl 4",
pages = "294-297",
doi = "10.2298/SARH08S4294R"
}

Radojević-Škodrić, S., Bogdanović, L., Jovanović, M., Baralić, I., Savin, M.,& Basta-Jovanović, G.. (2008). Polycystic kidney disease--autopsy review from the period 1987-2007. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 136 Suppl 4, 294-297.
https://doi.org/10.2298/SARH08S4294R

Radojević-Škodrić S, Bogdanović L, Jovanović M, Baralić I, Savin M, Basta-Jovanović G. Polycystic kidney disease--autopsy review from the period 1987-2007. in Srpski arhiv za celokupno lekarstvo. 2008;136 Suppl 4:294-297.
doi:10.2298/SARH08S4294R .

Radojević-Škodrić, Sanja, Bogdanović, L., Jovanović, M., Baralić, I., Savin, M., Basta-Jovanović, Gordana, "Polycystic kidney disease--autopsy review from the period 1987-2007" in Srpski arhiv za celokupno lekarstvo, 136 Suppl 4 (2008):294-297,
https://doi.org/10.2298/SARH08S4294R . .